[A Method Based on Ru(bpy)3 3+ Electrogenerated Chemiluminescence for Assessment of Antioxidant Property of Naturally Occurring Antioxidants].
Abstract We developed a flow injection analysis (FIA) method based on tris(2,2'-bipyridine)ruthenium(III) [Ru(bpy)3 3+] electrogenerated chemiluminescence for assessment of antioxidant property. The hydroxyl radical (∙OH) were generated by H2O photolysis using an ultraviolet/H2O photoreactor. The reactor comprised a polytetrafluoroethylene tube, a quartz container, and a low-pressure mercury lamp that predominantly emitted radiation at around 185 nm. When the hydroxyl radical and Ru(bpy)3 3+ were in contact, chemiluminescence was generated as background emission. The background emission decreased when antioxidan...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - February 6, 2019 Category: Drugs & Pharmacology Authors: Nobushi Y, Asamoto H, Uchikura K Tags: Yakugaku Zasshi Source Type: research

[Evaluation of Pharmacist-led Interview before Doctor Examination for Psychiatry Outpatients].
In conclusion, pharmacists can facilitate communication between patients and doctors through these interviews. These results indicate that the pharmacist-led interview before the doctor examination is a useful effort from the perspective of outpatients. PMID: 30713244 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - February 6, 2019 Category: Drugs & Pharmacology Authors: Shin K, Kobayashi D, Kawashiri T, Ushijima Y, Umeda Y, Kanazawa Y, Kamimura H, Shimazoe T Tags: Yakugaku Zasshi Source Type: research

[Questionnaire Survey on Collaboration with Medical Facilities/Nursing Home Care Facilities at Community Pharmacies].
In this study, we conducted a questionnaire survey of community pharmacies in Gifu City, which assessed the experience and attitudes regarding collaboration with other medical facilities. The survey items are: I. Participation in regional care meetings, II. Case discussion conferences, III. Joint workshops/study conferences, IV. Community service, V. Sharing information through medical cooperation network, and VI. Accompanying community pharmacists at home medical care. For the implementation of collaboration, the percentage of "not implemented" were as high as 70% or more in II, IV, V and VI. Regarding the attit...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - February 6, 2019 Category: Drugs & Pharmacology Authors: Tachi T, Ino Y, Shimauchi A, Noguchi Y, Sakai C, Iguchi K, Kano A, Teramachi H Tags: Yakugaku Zasshi Source Type: research

[Food Poisoning by Ginkgo Seeds through Vitamin B6 Depletion].
Abstract Overconsumption of Ginkgo biloba seeds induces food poisoning characterized by tonic-clonic convulsions and vomiting. The primary toxic component, 4'-O-methylpyridoxine (MPN), was purified from the seeds in 1985. This review includes the following aspects of ginkgo seed poisoning: 1) toxicity related to the content of MPN and MPN glucoside in G. biloba seeds; 2) the effect of MPN on vitamin B6 analogs, including an increase in pyridoxal and pyridoxic acid and decrease in pyridoxal-5'-phosphate plasma concentrations; 3) case reports of ginkgo seed poisoning in Asia, North America, and Europe, and their eff...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 6, 2019 Category: Drugs & Pharmacology Authors: Kobayashi D Tags: Yakugaku Zasshi Source Type: research

[Therapeutic Effects of Intranasal Sumatriptan for Cluster Headache].
Abstract To clarify the associated factors for negative response to sumatriptan nasal spray in patients with cluster headache, we investigated the involvement of clinical information, such as the characteristics of headaches, before commencing sumatriptan nasal spray treatment. There were 18 male patients and 4 female patients. A total of 17 responders and 5 non-responders to sumatriptan nasal spray participated in the present study. Three factors for negative response to sumatriptan nasal spray, "young age of onset", "psychiatric disorder", and "the headache is not in the orbit," wer...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 6, 2019 Category: Drugs & Pharmacology Authors: Ishii M, Katoh H, Imawaka M, Kasai H, Ishibashi M Tags: Yakugaku Zasshi Source Type: research

[Association between Elimination Half-life of Benzodiazepines and Falls in the Elderly: A Meta-analysis of Observational Studies].
Abstract Benzodiazepine receptor agonists (BZDRAs) have been associated with an increased risk of falls in the elderly. However, the association between the elimination half-life (t1/2) of BZDRAs and the difference between benzodiazepines (BZDs) and non-benzodiazepines (Z-drugs) has not been clarified. By conducting a meta-analysis of observational studies, we compared the risk of falls with respect to 1) short-acting BZDRAs (t1/2
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 6, 2019 Category: Drugs & Pharmacology Authors: Masudo C, Ogawa Y, Yamashita N, Mihara K Tags: Yakugaku Zasshi Source Type: research

[Effect of Methylcellulose (Cellulose Derivatives) on Ibuprofen-crushing Efficiency in Nano Pulverizer NP-100].
In conclusion, this results show that the appropriate addition amount of methylcellulose is different in the type of methylcellulose, and these changes of cumulative size frequency curve is useful as index to determine the concentration and type of additives in the nanoparticle production. PMID: 30606918 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 6, 2019 Category: Drugs & Pharmacology Authors: Nagai N, Yamasaki Y, Nakamura T, Otake H, Okamoto N Tags: Yakugaku Zasshi Source Type: research

[The Future of Osteoporosis Research and Treatment].
PMID: 30606919 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 6, 2019 Category: Drugs & Pharmacology Authors: Hinoi E, Arai K Tags: Yakugaku Zasshi Source Type: research

Safety of 90Y-ibritumomab Tiuxetan Treatment for Japanese Patients in Real-world Clinical Practice.
In conclusion, we showed that hematotoxicity is a major adverse event of 90Y-IT treatment and that the nadir time is later than that with conventional anticancer agents. Medical staff, including pharmacists, should direct attention to the initial symptoms of hematotoxicity, especially in those patients who have received several prior regimens. PMID: 30606920 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 6, 2019 Category: Drugs & Pharmacology Authors: Yoshikawa H, Sakurashita H, Izumitani S, Taogoshi T, Saeki Y, Matsuo H Tags: Yakugaku Zasshi Source Type: research

[Evaluation of the Cytotoxicity of Commercially Available Nail Adhesives].
We examined the cytotoxicity of the adhesives in V79 cells by a colony forming assay. In this test, 5 nail adhesives showed higher toxicity than 1 medical adhesive. Formaldehyde concentrations in the extract of adhesives were as follows: 17.5 to 24.2 μg/mL for nail adhesives and 7.4 μg/mL for medical adhesives. Cyanoacetate did not elicit cytotoxicity at the final concentration up to 1000 μM. However, formaldehyde showed cytotoxicity, with an IC50 of 79 μM (2.4 μg/mL). Taken together, the cytotoxicity of nail adhesives could be due to the formaldehyde generated by the hydrolysis of cyanoacrylate. It seems im...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 6, 2019 Category: Drugs & Pharmacology Authors: Hoshikawa N, Ono Y, Shioda H, Suzuki T, Inomata A, Moriyasu T Tags: Yakugaku Zasshi Source Type: research

[Transcription Regulators and Bone Metabolism].
Abstract Although the transcriptional modulator interferon-related developmental regulator 1 (Ifrd1) has been identified as a transcriptional coactivator/repressor in various cells, including bone-resorbing osteoclasts, no attention has been paid to its role in bone-forming osteoblasts. Therefore, in this study we show that Ifrd1 is a critical mediator of both osteoblastogenesis and osteoclastogenesis through its expression in osteoblasts. Ifrd1 deficiency enhanced both osteoblast differentiation and maturation, and increased the expression of Runt-related transcription factor 2 and Osterix. A coculture experiment...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 6, 2019 Category: Drugs & Pharmacology Authors: Hinoi E, Iezaki T, Fukasawa K, Kaneda K Tags: Yakugaku Zasshi Source Type: research

[A Novel Oral Anti-osteoporosis Drug with Osteogenesis-promoting Effects via Osteoblast Differentiation].
In conclusion, KY-273 is a promising candidate for use as an oral anti-osteoporosis drug with osteogenesis promoting effects. PMID: 30606923 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 6, 2019 Category: Drugs & Pharmacology Authors: Kitao T, Ito Y, Fukui M, Yamamoto M, Shoji Y, Takeda S, Shirahase H Tags: Yakugaku Zasshi Source Type: research

[Significance of Bone Turnover Marker Measurement in the Treatment of Osteoporosis].
Abstract The bone turnover marker (BTM) measurement in osteoporosis treatment includes evaluation of bone metabolism status or evaluation of bone loss risk level, determination of fracture risk, and evaluation of drug treatment. Currently, by using the BTM, it has become possible to evaluate and select an effective treatment for osteoporosis. The BTM has become widely used as a clinical test item in actual clinical practice. Patients' low adherence to osteoporosis medication regimens increases the risk of vulnerable fractures and affects the cost effectiveness of therapeutics. A joint working group has been establ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 6, 2019 Category: Drugs & Pharmacology Authors: Miura M, Satoh Y Tags: Yakugaku Zasshi Source Type: research

[Development of Novel Osteoporosis Screening Methods Using FRAX].
Abstract Fragility fractures associated with osteoporosis can have a major impact on a person's "activities of daily living" (ADL) and life span. Therefore, osteoporosis and its complications must be addressed by early screening and prompt intervention. A Fracture Risk Assessment Tool (FRAX) has been developed by the WHO. FRAX allows the calculation/estimation of absolute fracture risk over a 10-year period. The FRAX can be completed using a free application form, accessible online. The relationship between FRAX and the young adult mean (YAM) was investigated in order to calculate the cut-off value of FR...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 6, 2019 Category: Drugs & Pharmacology Authors: Yamamoto N, Tsuchiya H Tags: Yakugaku Zasshi Source Type: research

[Development of a Novel Method for the Treatment and Prevention of Diabetes Mellitus].
PMID: 30606926 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 6, 2019 Category: Drugs & Pharmacology Authors: Shimizu K, Oniki K Tags: Yakugaku Zasshi Source Type: research

[A Nanocarrier System for Mitochondrial Delivery Targeted to a Pancreatic Beta Cell].
Abstract The destruction of β cells of pancreatic islets results in a reduced level of insulin secretion, thus resulting in the onset of diabetes. Diabetes caused by such a decrease in insulin secretion has been reported to be associated with mitochondrial dysfunction. Because of this, mitochondrial therapy would be expected to be a useful and productive strategy for the treatment of this disease. We previously reported the development of a MITO-Porter, a liposome-based nanocarrier that permits macromolecular cargos to be delivered into mitochondria via membrane fusion. In this presentation, we present our cu...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 6, 2019 Category: Drugs & Pharmacology Authors: Yamada Y Tags: Yakugaku Zasshi Source Type: research

[The Investigation of Genes, Using an Improved Adenovirus Vector, and Food for the Treatment and Prevention of Type 2 Diabetes Mellitus].
We examined the effects of such genes on T2DM using an improved adenovirus vector that demonstrates safer, higher, and longer-term transgene expression than that of the conventional adenovirus vector. We also found that certain foods inhibit the progression of non-alcoholic fatty liver disease, which is related to T2DM. In this review, we introduce our research results, demonstrating how genes and food independently contribute to the mechanisms of T2DM pathology. PMID: 30606928 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 6, 2019 Category: Drugs & Pharmacology Authors: Shimizu K, Nishinaka T, Tomita K, Terada T Tags: Yakugaku Zasshi Source Type: research

[A Multifaceted Approach regarding the Association of the DsbA-L Gene with the Risk of Obesity-related Diseases Based on Clinical Pharmacogenetics].
Abstract Adiponectin, the most abundant adipose tissue-derived adipocytokine, improves insulin sensitivity and has anti-inflammatory properties. Disulfide-bond A oxidoreductase-like protein (DsbA-L) is a key molecule in the multimerization of adiponectin (i.e., activation of adiponectin). In mice, liver-specific knockout of the Dsba-L gene impaired the mitochondrial function in hepatocytes and exacerbated the high-fat-diet-induced fatty liver. In addition, the DsbA-L mRNA level is negatively correlated with body mass index (BMI) in humans. We recently investigated the clinical impact of the DsbA-L gene on lifestyl...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 6, 2019 Category: Drugs & Pharmacology Authors: Oniki K, Saruwatari J Tags: Yakugaku Zasshi Source Type: research

[Progress of Comprehensive Research on Infectious Diseases and Cancer for Next-generation Drug Discovery ~Latest Researches on Human Cancer-related Pathogens Powered by Pharmaceutical Scientists~].
PMID: 30606930 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 6, 2019 Category: Drugs & Pharmacology Authors: Noguchi K, Fujimuro M Tags: Yakugaku Zasshi Source Type: research

[Epstein-Barr Virus Genome Replication as a Molecular Target for Cancer Therapy].
Abstract Epstein-Barr virus (EBV), a human oncogenic virus, is a B cell-tropic herpesvirus and has the ability to immortalize normal B cells during latent infection. The Epstein-Barr nuclear antigen 1 (EBNA1) protein of EBV is expressed in the most EBV latently infected cells and binds to a specific viral genome region termed "oriP" (origin of plasmid replication) to maintain the stability of the approximately 170 kb double-stranded circular virus genomic DNA (episome) in cells. EBV elimination is thought to inhibit progression of EBV-associated malignancies, and the EBNA1-dependent mechanisms for EBV ep...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 6, 2019 Category: Drugs & Pharmacology Authors: Noguchi K Tags: Yakugaku Zasshi Source Type: research

[Replication Machinery of Kaposi's Sarcoma-associated Herpesvirus and Drug Discovery Research].
Abstract Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Castleman's disease. While liposomal doxorubicin has been used as an effective treatment for KS patients, the cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) regimen used for PEL patients was reported to have 1-year survival rates of less than 40%. Moreover, the development of anti-KSHV drugs inhibiting viral replication has been delayed. KSHV establishes a lifelong infection in its host and alternates between a "latent infection" and "lytic ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 6, 2019 Category: Drugs & Pharmacology Authors: Watanabe T, Fujimuro M Tags: Yakugaku Zasshi Source Type: research

[The Molecular Basis of Drug Discovery Targeting the Regulatory Mechanism of MAPK Signaling via the Spatial Regulation of RNA-binding Proteins].
Abstract Mitogen-activated protein kinase (MAPK) is a highly conserved serine/threonine kinase that regulates multiple cellular processes such as cell proliferation, differentiation, apoptosis, and inflammation. Rnc1 has been identified as a regulator of Pmk1 MAPK signaling, a homologue of extracellular signal-regulated kinase (ERK)-1 MAPK in mammals. Rnc1 encodes a K-homology (KH)-type RNA-binding protein (RBP). Previously, it was reported that Rnc1 acts as a negative regulator of Pmk1 MAPK signaling through the mRNA stabilization of Pmp1, the MAPK phosphatase for Pmk1 in our laboratory. We analyzed the spatial r...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 6, 2019 Category: Drugs & Pharmacology Authors: Satoh R Tags: Yakugaku Zasshi Source Type: research

[Human Papillomavirus Carcinogenesis Mediated by APOBEC Mutagenesis].
Abstract Persistent infection with oncogenic human papillomaviruses (HPVs) is necessary for the development of cervical cancer, although the accumulation of somatic mutations in the host genome is also required for the generation of invasive cervical cancer. Recent studies have demonstrated concomitant genetic changes in the HPV genome; however, their relevance to cervical carcinogenesis is poorly understood. Here we review our recent study investigating the within-host genetic diversity of HPV and its relationship with cervical cancer progression through deep sequencing analyses of viral whole-genome sequences in...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 6, 2019 Category: Drugs & Pharmacology Authors: Kukimoto I Tags: Yakugaku Zasshi Source Type: research

[From the Establishment of Hepatitis B Virus Cell Culture Systems to Drug Discovery].
Abstract The development of antiviral agents enables the control of chronic infectious diseases caused by infection with herpesviruses, human immunodeficiency virus, and hepatitis C virus. In contrast, antiviral treatment against hepatitis B virus (HBV) infection remains a significant area for improvement. One of the main barriers hampering the progress of HBV research has been a lack of cell culture systems efficiently reproducing the viral proliferation process. Recently, cell line-based HBV infection systems have been developed which are useful to analyze the mechanisms of HBV replication and to screen for new ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 6, 2019 Category: Drugs & Pharmacology Authors: Fukano K, Watashi K Tags: Yakugaku Zasshi Source Type: research

[Anti-hepatitis C Virus Strategy Targeting the Entry Steps].
Abstract Hepatitis C virus (HCV) infection is a major leading cause of chronic severe liver diseases such as cirrhosis and hepatocellular carcinoma. The recent direct-acting antivirals (DAAs) for the treatment of HCV infection offer very high cure rates, but DAAs are vulnerable to drug resistance because HCV is an RNA virus, which generally has very high mutation rates. DAA resistance-associated variants of HCV could reduce the effectiveness of DAAs in the future. Thus, the continuous development of new anti-HCV drugs against different target molecules is needed. We have been studying the host factors involved in ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 6, 2019 Category: Drugs & Pharmacology Authors: Fukasawa M Tags: Yakugaku Zasshi Source Type: research

Validation of a Reorganized Training Program Using a Cognitive Behavioral Therapy Approach to Enable Community Pharmacists to Provide Empathic Patient Counseling.
Abstract To enable community pharmacists to provide empathic patient counseling, we developed and validated a training program based on the cognitive behavioral therapy approach (CBT-A) in our previous study. The major focus points of the re-structured training program were "inclusion of basic communication skills", "exemplifying correspondence involving CBT-A using pre-recorded video(VTR)", and "approach methods for cases where counter-evidence is unavailable". The training program lasted for 4 h per day, for a total of 8 h. We also performed role-play scenarios on information gather...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 6, 2019 Category: Drugs & Pharmacology Authors: Tanuma K, Watanabe F, Maeda H, Saitoh N, Kamei M Tags: Yakugaku Zasshi Source Type: research

[Development of a Nano DDS for Cancer Immunotherapy Based on Llipid Nanoparticles].
Abstract The appearance of immune checkpoint inhibitors has been a major turning point in cancer therapy. The success of immune checkpoint therapy has revolutionized the field of cancer therapy, and immunotherapy has joined the cancer treatment ranks as a pillar. To induce effective anti-tumor immune responses, it is necessary both to enhance the activity of immune cells and to block immune suppression by tumor cells. Carrier type drug delivery systems based on nanobiotechnology (nano DDS) represent a potentially useful technology for efficiently achieving both: enhancement of the activity of immune cells and bloc...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - December 8, 2018 Category: Drugs & Pharmacology Authors: Nakamura T Tags: Yakugaku Zasshi Source Type: research

[Application of Lectin from Catfish Eggs to Cancer Therapy: A Fundamental Study].
Abstract Silurus asotus egg lectin (SAL) is an α-galactoside-binding protein, isolated from the egg of catfish. It belongs to the rhamnose-binding lectin family that binds to Gb3 glycan (Galα1-4Galβ1-4Glc). SAL has resulted in the induction of early apoptosis in the Raji cell line, which is a Burkitt's lymphoma cell line expressing Gb3. The apoptosis was characterized by i) increased externalization of phosphatidylserin via multidrug resistance 1 P-glycoprotein (MDR1 P-gp), and ii) reduced cell size through the activation of voltage-gated potassium channel Kv1.3. Although the incorporation of prop...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - December 8, 2018 Category: Drugs & Pharmacology Authors: Sugawara S Tags: Yakugaku Zasshi Source Type: research

[MET/ERK and MET/JNK Pathway Activation Is Involved in BCR-ABL Inhibitor-resistance in Chronic Myeloid Leukemia].
Abstract Resistance to the breakpoint cluster region-abelson (BCR-ABL) tyrosine kinase inhibitor (TKI), imatinib, poses a major problem in the treatment of chronic myeloid leukemia (CML). Imatinib resistance often results from a secondary mutation in BCR-ABL1. However, the basis of this BCR-ABL1-independent resistance in the absence of such mutation remains to be elucidated. The aim of the present study is to identify the mechanism of imatinib resistance in CML. To gain insight into BCR-ABL1-independent imatinib resistance mechanisms, we performed an array-based comparative genomic hybridization. We identified var...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - December 8, 2018 Category: Drugs & Pharmacology Authors: Tsubaki M Tags: Yakugaku Zasshi Source Type: research

[Optimization of Nasal Drug Absorption from Powder Formulations: The Feasibility of Controlling Drug Absorption by the Use of Pharmaceutical Excipients].
Abstract Nasal application of powder formulations has garnered attention because of its significant potential for systemic drug delivery. Because a powder drug must first diffuse from the formulation and dissolve in the nasal cavity fluid before transepithelial permeation, dissolution and diffusion are distinct but important factors for nasal drug absorption. Since the formulation is directly administered onto the nasal mucosal surface, the effect of excipients on drug absorption may be significant. Therefore, the influence of excipients on nasal drug absorption was evaluated. Three types of hydroxypropyl cellulos...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - December 8, 2018 Category: Drugs & Pharmacology Authors: Tanaka A Tags: Yakugaku Zasshi Source Type: research

[Current Trends in Analytical Technologies Which Promote the Development of Biopharmaceuticals].
PMID: 30504660 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - December 8, 2018 Category: Drugs & Pharmacology Authors: Ishii-Watabe A, Uchiyama S Tags: Yakugaku Zasshi Source Type: research

[The Identification of Critical Quality Attributes (CQAs) for the Development of Antibody Drugs].
Abstract In the development of quality biopharmaceutical drugs, it is the level of knowledge gained, not the volume of data, which provides the basis for science-based submissions and their regulatory evaluation [International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) Q8 (R2)]. The identification of critical quality attributes (CQAs) is important as the initial step for quality by design (QbD) strategies. The impact of each potential critical attribute (pCQA) is assessed by using a systematic and scientific approach with respect to bioactivity, pharmacokinetics (PK...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - December 8, 2018 Category: Drugs & Pharmacology Authors: Saitoh S Tags: Yakugaku Zasshi Source Type: research

[Site-specific O-Glycosylation Analysis of Therapeutic Fc-fusion Protein by Mass Spectrometry].
Abstract Therapeutic Fc-fusion proteins, created by linking bioactive peptides or receptor proteins to the Fc moiety of IgG, are currently being developed. In this development process, a Gly-Gly-Gly-Ser linker (G4S linker) is often used to link the peptide/protein and the Fc portion. O-xylose-type core glycans of glycosaminoglycan are known to attach to the Ser residue on the GSG motif in the G4S linker peptide repeats of the Fc fusion protein produced using the Chinese hamster ovary (CHO) cell expression system. In addition, a recent report demonstrated that unexpected mucin-type O-glycosylations occurred on a pe...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - December 8, 2018 Category: Drugs & Pharmacology Authors: Hashii N, Ishii-Watabe A Tags: Yakugaku Zasshi Source Type: research

[Structural Biological Approach to Biopharmaceuticals].
Abstract Detailed structural characterization of protein biopharmaceuticals is a critical step in research and development; however, this step is often hampered by the structural complexities associated with glycosylation. Most protein biopharmaceuticals are modified with structurally heterogeneous and dynamic oligosaccharides which govern the physicochemical properties, functionality, pharmacokinetics, and potential pathogenicity of these glycoproteins. Considering this, we have developed a structural biological approach to describe the dynamic three-dimensional structures and interactions of glycoproteins as bio...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - December 8, 2018 Category: Drugs & Pharmacology Authors: Kato K, Yanaka S, Yagi H Tags: Yakugaku Zasshi Source Type: research

[Toward the Proper Biophysical Characterization of Aggregates in Biopharmaceuticals].
Abstract Biopharmaceuticals are often formulated as liquid dosage forms. During manufacturing and storage, protein molecules and active pharmaceutical ingredients form aggregates due to various stresses, including shaking and agitation, as well as by contact with silicone oils coated on pre-fillable syringes. The diameter of protein aggregates ranges from 15-20 nm, and that of dimers comprising a large number of antibody molecules can be up to 100 μm. Among these aggregates, those with a diameter of
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - December 8, 2018 Category: Drugs & Pharmacology Authors: Uchiyama S Tags: Yakugaku Zasshi Source Type: research

[What Pharmacists Should Know about So-called "Health Foods"].
[What Pharmacists Should Know about So-called "Health Foods"]. Yakugaku Zasshi. 2018;138(12):1509-1510 Authors: Uneyama C PMID: 30504665 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - December 8, 2018 Category: Drugs & Pharmacology Authors: Uneyama C Tags: Yakugaku Zasshi Source Type: research

[Current Status of Health Foods Including Their Interactions with Drugs and Adverse Events].
Abstract Although many people (and patients) in Japan currently consume health foods such as supplements, few have proper knowledge of their usefulness and safety. In December 2015, the Food Safety Commission of Japan issued a report and 19 messages mainly on the safety of health foods to disseminate appropriate knowledge to consumers. The report divided health food risks into three categories: 1) risks as food (e.g., increased lung cancer risk in smokers consuming excess β-carotenoid); 2) risks as health foods (e.g., short consumption history, drug contamination, poor quality of active ingredients, and inter...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - December 8, 2018 Category: Drugs & Pharmacology Authors: Saito Y Tags: Yakugaku Zasshi Source Type: research

[Information System on the Safety and Effectiveness of Health Foods and Recent Topics].
This article provides an overview of the HFNet. Additionally, findings from our recent survey and educational interventions among college students are discussed. We hope that this article will be helpful for pharmacists and other healthcare professionals who provide consultations on the use of health foods. PMID: 30504667 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - December 8, 2018 Category: Drugs & Pharmacology Authors: Chiba T Tags: Yakugaku Zasshi Source Type: research

[Problems with Advertisements for Health Foods].
Abstract We have been studying the way advertisements for medicines have been monitored by the Health, Labour and Welfare Sciences Research Grants. In the last fiscal year, we identified products that were being advertised to general consumers, such as OTC drugs and designated quasi-drugs, and made recommendations to the Ministry of Health, Labour and Welfare on the methods of advertisement. Members of our research group, including physicians, pharmacists, and consumers, pointed out that advertisements for so-called health foods and foods with functional claims were much more unregulated than those for drugs, incl...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - December 8, 2018 Category: Drugs & Pharmacology Authors: Shiragami M Tags: Yakugaku Zasshi Source Type: research

[Current Problems Associated with Overseas Health Products].
Abstract In recent years, consumer interest in health and health foods (e.g., dietary supplements) has increased, and the types of and market for health foods have also expanded rapidly. The safety of health foods is a significant concern in many countries. Numerous adverse events associated with the consumption of health foods have been reported. There are cases that have resulted in serious liver failure, renal failure, and death in other countries. These products may contain undeclared medical ingredients and toxic chemical compounds that are illegally and intentionally added or contain natural plant toxins. Pr...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - December 8, 2018 Category: Drugs & Pharmacology Authors: Toda M, Uneyama C Tags: Yakugaku Zasshi Source Type: research

[Design, Synthesis and Structure-activity Relationship Study of a Series of Bis(bibenzyl)-type Natural Products, Riccardin C Derivatives, as Candidate Anti-MRSA Agents].
Abstract We previously showed that a naturally occurring macrocyclic bis(bibenzyl) derivative, riccardin C (RC), exhibits antibacterial activity towards methicillin-resistant Staphylococcus aureus (MRSA), with a potency comparable to that of the clinically used drug vancomycin. Here, we synthesized a series of RC derivatives to explore the structure-activity relationships (SAR). The SAR results clearly indicated that the number and positions of the phenolic hydroxyl groups are primary determinants of the anti-MRSA activity. Pharmacological characterization of the macrocyclic bis(bibenzyl) derivatives, together wit...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - December 8, 2018 Category: Drugs & Pharmacology Authors: Miyachi H, Kuroda T Tags: Yakugaku Zasshi Source Type: research

[Effects of Using the Adherence Score Sheet According to Application Timing in Improving Medication Adherence in SETSUYAKU-BAG Campaign].
This study aimed to determine the effects of using adherence score sheets according to application timing in improving medication adherence among non-adherent outpatients. In community pharmacies, both patients and pharmacists evaluated medication adherence based on application timing (morning, noon, evening, and before going to bed) in 11 levels (0-10) for>4 months. A total of 58 outpatients were included in the study. The median scores among application timing at intermediate (patient 9.3, pharmacist 9.0) and final (patient 9.5, pharmacist 9.5) analyses were significantly higher than that at baseline (patient 7.6, pha...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - December 8, 2018 Category: Drugs & Pharmacology Authors: Kobayashi D, Koyanagi K, Kubota T, Maruyama M, Miisho T, Kaneko E, Kawanami M, Kihara T, Takaki J, Nakashiba T, Nagatomi S, Seo T, Tanaka T, Shimazoe T Tags: Yakugaku Zasshi Source Type: research

[Analyses of Volatile Components of Lavender (Lavandula angustifolia HIDCOTE and Lavandula x intermedia GROSSO) as Influenced by Cultivar Type, Part, and Growth Season].
Abstract Volatile components originating from Lavandula angustifolia Hidcote and Lavandula x intermedia Grosso plants cultivated in a medicinal plant garden of Hoshi University located in southern Tokyo were investigated using thermal desorption-GC-MS. Sampling of the flowers and herbs of the lavender was performed at different developmental stages, i.e., summer, autumn, and winter (herbs only) using solid phase micro extraction fibers. Linalool, linalyl acetate, β-caryophyllene, β-myrcene, α-ocimene, β-ocimene, and terpinen-4-ol were the predominant constituents originating from the flowers o...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - December 8, 2018 Category: Drugs & Pharmacology Authors: Kasai H, Kubota Y Tags: Yakugaku Zasshi Source Type: research

[Analysis by Using Roter Method of Interaction Process Analysis (RIAS) of the Ability of Pharmacy Students to Communicate after Clinical Training for Pharmacy].
Abstract Communication education is now necessary for pharmaceutical education since the role of pharmacists has expanded from "medicine-based" to "person-based". However, a standard for assessing the effectiveness of a communication education program has not been established. Hence, the aim of this study was to determine the effectiveness of clinical training in pharmacy for enhancing the ability of pharmacy students to communicate. Role playing with simulated patients was performed by pharmacy students before and after clinical practice for pharmacy, and the effects of learning were analyzed ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - December 8, 2018 Category: Drugs & Pharmacology Authors: Takekuma Y, Mori A, Kobayashi M, Yamada Y, Sato Y, Narumi K, Furugen A, Sugawara M Tags: Yakugaku Zasshi Source Type: research

[Analysis of Time-to-onset and Onset-pattern of Interstitial Lung Disease after the Administration of Monoclonal Antibody Agents].
Abstract The aim of this study has been to investigate the time-to-onset and onset-pattern of drug-induced interstitial lung disease (DILD) after the administration of monoclonal antibodies through the use of the spontaneous adverse reaction reporting system of the Japanese Adverse Drug Event Report database. DILD datasets for adalimumab, bevacizumab, cetuximab, denosumab, golimumab, infliximab, nivolumab, panitumumab, pembrolizumab, tocilizumab, and trastuzumab were used to calculate the median time-to-onset of DILD, as well as the Weibull distribution parameters. The median time-to-onset of DILD for pembrolizuma...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - December 8, 2018 Category: Drugs & Pharmacology Authors: Komada F, Nakayama Y, Takara K Tags: Yakugaku Zasshi Source Type: research

[The Effectiveness of Counseling Using Preventative Informational Sheets with Climate and Environmental Data from Insurance Pharmacies in Preventing Worsened Asthma Symptoms].
Abstract We investigated the possibility that having pharmacists give asthma patients informational sheets on climate and environmental changes at insurance pharmacies during patient counseling might prevent the worsening of asthma symptoms. Patients with hyperlipidemia were comparative subjects. We created informational sheets about climate and environmental changes and their influence on asthma. During patient counseling, pharmacists gave them to all asthma patients who visited insurance pharmacies over a period of 2 months, between November and December 2017. Based on previous studies, we called days which show...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - December 5, 2018 Category: Drugs & Pharmacology Authors: Iwade K, Shimoji S, Masaki H, Sakai T, Tanabe K, Goto N, Ootsu F Tags: Yakugaku Zasshi Source Type: research

[Elucidation of a New Mechanism of Onset of Insulin Resistance: Effects of Statins and Tumor Necrosis Factor- α on Insulin Signal Transduction].
[Elucidation of a New Mechanism of Onset of Insulin Resistance: Effects of Statins and Tumor Necrosis Factor-α on Insulin Signal Transduction]. Yakugaku Zasshi. 2018;138(11):1329-1334 Authors: Takaguri A Abstract Impaired insulin signaling in adipose tissue and skeletal muscle causes insulin resistance associated with the development of type 2 diabetes. However, the molecular mechanisms underlying insulin resistance remain to be elucidated. In this review, we describe the current understanding of the effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) and tu...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - November 3, 2018 Category: Drugs & Pharmacology Authors: Takaguri A Tags: Yakugaku Zasshi Source Type: research

[Reaction Development Utilizing the Features of Chemical Elements and Synthesis of Marine Natural Products].
Abstract Marine natural products and biologically active compounds often contain cyclic ether units. Thus, regio- and stereoselective construction of these structures has long been a topic of interest in organic synthesis. This review summarizes new synthetic approaches to polycyclic ether natural products utilizing the features of chemical elements. PMID: 30381641 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - November 3, 2018 Category: Drugs & Pharmacology Authors: Saito T Tags: Yakugaku Zasshi Source Type: research

[Accumulation Mechanism of 2-Nitroimidazole-based Hypoxia Imaging Probes Revealed by Imaging Mass Spectrometry].
Abstract Hypoxia in tumor tissues plays a pivotal role in tumor progression and angiogenesis, and is associated with cancer therapeutic resistance. For the diagnosis of hypoxia, non-invasive imaging techniques, especially positron emission tomography (PET) with 2-nitroimidazole-based probes, are used, since 2-nitroimidazole-based probes are considered to undergo reductive metabolism on their 2-nitroimidazole moiety and become trapped in hypoxic cells. However, the detailed mechanism of their accumulation remains unclear because of the difficulty in estimating the metabolites by radioisotopic analysis. Imaging mass...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - November 3, 2018 Category: Drugs & Pharmacology Authors: Shimizu Y Tags: Yakugaku Zasshi Source Type: research

[Development of the Direct Transformations of Aromatic C-H Bonds Using a Heterogeneous Metal Catalyst].
Abstract Heterogeneous metal catalysts constitute a very important tool for the synthesis of functional materials and fine chemicals owing to their high efficiency, robustness, and facile recyclability. Biaryls are privileged structural motifs in many natural products, chiral ligands, and catalysts. The oxidative biaryl coupling reaction is one of the most promising methods for biaryl synthesis in terms of atom and step economies. However, although oxidative biaryl coupling of naphthols has been studied thoroughly, the coupling of aryl amines providing biaryl amines like 2,2'-diamino-1,1'-binaphthyl (BINAM) and 2-...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - November 3, 2018 Category: Drugs & Pharmacology Authors: Matsumoto K Tags: Yakugaku Zasshi Source Type: research