[Development of Hospital Formulations Based on Medical Need].
In this study, we prepared and evaluated a mouthwash for stomatitis taking into consideration the solubilization of RB. RB nanoparticles were prepared by the wet-milling technique using various forms of hydroxypropyl cellulose (HPC-L, -SL, and -SSL) and sodium lauryl sulfate (SLS). RB nanoparticles sized between 126.6 and 286.8 nm were obtained under various conditions. From the results of zeta potential measurement and evaluation of their dispersibility, it appeared that the prepared nanosuspensions were stable. Furthermore, adhesion of the nanoparticles to the mucous membrane in the oral cavity was evaluated using quartz...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 6, 2019 Category: Drugs & Pharmacology Authors: Kawano Y, Hanawa T Tags: Yakugaku Zasshi Source Type: research

[Development of a Breathable Protective Ointment for Moisture-associated Skin Damage].
Abstract In this symposium, we present a novel breathable protective ointment (BPO) formulation developed at the University of Shizuoka for the prevention of moisture-associated skin damage (MASD) intended for use in healthcare settings. MASD occurs when moisture is in constant contact with the skin for prolonged periods of time, causing degradation of the skin barrier. Exposure to physical or chemical stimuli in addition to moisture may lead to different types of moisture-associated dermatitis such as incontinence-associated or periwound dermatitis. Another type of moisture-associated dermatitis, diaper dermatiti...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 6, 2019 Category: Drugs & Pharmacology Authors: Miyazaki Y, Asano M, Uchino T, Kagawa Y Tags: Yakugaku Zasshi Source Type: research

[Examples of Clinical Formulation Design at a University and Response to Clinical Need].
Abstract In the healthcare setting, the handling of clinical preparations is essential for the development of tailor-made pharmaceutical agents. However, during the design and development of new clinical formulations, pharmacists may encounter various questions and problems related to handling the formulations, such as a lack of knowledge of and experience in prescription design. In addition, if pharmacists require assistance to solve problems, it is rare to find a person with sufficient knowledge of and experience with the formulation in their facilities, and there are few connections among facilities; therefore,...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 6, 2019 Category: Drugs & Pharmacology Authors: Yonemochi E Tags: Yakugaku Zasshi Source Type: research

[Translational Research Focused on Hospital-prepared Drugs in Japan: Developing and Accessing an Approach Using an Evidence Database].
In this study, we show our recent approach to developing hospital preparations into commercially available drugs. Our first endpoint was to start phase 2 clinical trials of hospital-prepared drugs. The second endpoint was to determine whether the drugs could continue to phase 3 trials. We have developed an evidence database on 107 hospital-prepared drugs by performing a literature survey on each drug for references to the words "stability", "efficacy", and "safety". If evidence is lacking, in vitro study results are compiled in the database, which will be needed when initiating clinical trials...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 6, 2019 Category: Drugs & Pharmacology Authors: Momo K, Kanezaki Y, Kawano Y, Hanawa T Tags: Yakugaku Zasshi Source Type: research

[The Current State and Future Prospects of Population Pharmacokinetic Research in Post-marketing Clinical Studies in Japan].
Abstract Population pharmacokinetics (PPK) is a useful approach to the evaluation of drug pharmacokinetics in patients and is a widely used method for the evaluation of pharmacokinetics in clinical trials. PPK uses a statistical model to calculate population parameters, their variance, and covariates from sparse and unbalanced data in a large target population. Population parameters can subsequently be used to establish individual prescribing regimens for specific patients. Post-marketing clinical studies using PPK analysis have been reported by medical and academic institutions in order to complement the poor pha...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 6, 2019 Category: Drugs & Pharmacology Authors: Watanabe-Uchida M, Watanabe T, Narukawa M Tags: Yakugaku Zasshi Source Type: research

[Pharmacological Effects of Yokukansankachimpihange on Urinary Catecholamine in Restraint-stressed Mice].
Abstract Herbal medicines, acupuncture and moxibustion are often used for unidentified complaints. It is well known that catecholamine secreted by the sympatho-adrenal medullary system primarily functions to increase cardiac output and raise glucose levels in the blood during acute stress. In the present study, the effects of yokukansankachimpihange (YKSKCH, a Kampo medicine) on urinary catecholamine in mice that were repeatedly stressed by restraining were examined. Restraint stress (240 min/d×3 d×3 cycles, daytime: 12:00-16:00) induced a marked increase in noradrenaline (NA) and adrenaline (A) levels...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 6, 2019 Category: Drugs & Pharmacology Authors: Michihara S, Han LK, Fujita N, Shibahara N, Takahashi R Tags: Yakugaku Zasshi Source Type: research

[Effects of Renal Function Evaluation with or without Serum Creatinine Adjustment on Cisplatin/Fluorouracil Therapy for Cervical Cancer].
Abstract The dosage of cisplatin is adjusted according to creatinine clearance (Ccr) estimated by the Cockcroft-Gault formula, which is commonly used as a marker for renal function. It is known that different serum creatinine (Scr) levels are reported depending on the analytical methods utilized such as the Scr level by the enzyme method being lower than that by the Jaffe method. Although the enzyme method is used in Japan, most drug dosages, including cisplatin, are adjusted according to the estimated Ccr using the Jaffe method-based Scr level. The purpose of this study was to investigate whether assessment of re...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 6, 2019 Category: Drugs & Pharmacology Authors: Takagi M, Sagara A, Ishizawa A, Ito A, Miyazaki M, Senzaki K, Nagai T, Yamada K Tags: Yakugaku Zasshi Source Type: research

[Systematic Review of Case Reports on the Adverse Events Due to Health Food Intake by Cancer Patients].
Abstract Cancer patients use health foods (HFs) as complementary and alternative medicine, although the details of their adverse events (AEs) are unclear. We searched three databases [PubMed, "Igaku Chuo Zasshi", and Information System on Safety and Effectiveness for Health Foods website (https://hfnet.nibiohn.go.jp/)] for case reports on AEs related to HF intake in cancer patients published before October 2018. Of the matched reports, 76 studies and 92 patients (31 in Japan, 61 overseas) that met the selection criteria were included in this review. Thus, the severity of AEs and outcomes were not related...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 6, 2019 Category: Drugs & Pharmacology Authors: Kojima A, Sato Y, Nishijima C, Umegaki K, Chiba T Tags: Yakugaku Zasshi Source Type: research

[Suggestion of Approached Method and the Personal Prescription Notebook Proposed for Pharmacotherapeutic Management of Patients with a Memory Disorder].
Abstract Patients with cognitive dysfunction caused by dysmnesia face difficulties in memorizing and learning general concepts; therefore, they encounter trouble in taking medications. Recently, a prescription notebook has been shown to be useful for patients receiving pharmacotherapy; however, it is not yet clear whether a common prescription notebook is useful for patients with a memory disorder. In our study, using a questionnaire for 61 patients, we first determined the benefits of and improvement in the drug administration guidance provided by a pharmacist to patients with a memory disorder compared with thos...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 6, 2019 Category: Drugs & Pharmacology Authors: Goto-Torii A, Toyoyoshi Y, Yoshikawa M, Yasuda K, Hino T, Hayashi T Tags: Yakugaku Zasshi Source Type: research

[Development of an Immune Regulation Technology Targeting the Skin and Promotion of the Practical Applications of Transcutaneous Vaccination/Immunotherapy].
Abstract In the premise of vaccination and allergen-specific immunotherapy, transcutaneous formulations have an advantage over conventional subcutaneous injections in terms of convenience, simplicity of delivery, and painless administration into the skin. Additionally, since transcutaneous formulations can be rendered cold-chain free, they do not require expert handling during transportation, storage, and stockpiling, which enables reductions in costs and distribution to distant areas. Furthermore, transcutaneous formulations are effective for improving adherence in children with phobias toward injection needles a...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 3, 2019 Category: Drugs & Pharmacology Authors: Okada N Tags: Yakugaku Zasshi Source Type: research

[Regulation of Extracellular Redox Homeostasis in Tumor Microenvironment].
Abstract Excessive generation of reactive oxygen species (ROS) has been implicated in the progression of tumors. Superoxide dismutase 3 (SOD3) is a copper-containing secretory antioxidative enzyme that plays a critical role in redox homeostasis, particularly in extracellular spaces. Considerable evidence suggests that SOD3 protein expression is significantly decreased or lost in several tumor tissues, and this loss results in tumor metastasis. On the other hand, epigenetic disturbances, including DNA hyper-/hypomethylation, histone de/acetylation, and histone de/methylation, may be involved in tumorigenesis and th...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 3, 2019 Category: Drugs & Pharmacology Authors: Kamiya T Tags: Yakugaku Zasshi Source Type: research

[The Front Line of the NAFLD/NASH Study Reported from the Pharmaceutical Field-Feedback from Basic Research to Medical Treatment and Pharmacist Activity].
PMID: 31474629 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 3, 2019 Category: Drugs & Pharmacology Authors: Tokuyama S, Ih Kim K Tags: Yakugaku Zasshi Source Type: research

[Overview of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis Management].
Abstract The number of patients with chronic liver diseases is expected to decline due to progress in antivirus therapy, including direct-acting antivirals for hepatitis C and nucleot(s)ide analogues for hepatitis B. On the other hand, the number of patients with nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH) in the setting of metabolic syndrome has been increasing worldwide. Hepatocellular carcinoma (HCC) arises in the setting of chronic hepatic inflammation and liver cirrhosis associated with NAFLD/NASH. However, the detailed clinical features of NAFLD/NASH and NAFLD/NASH-derived HCC ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 3, 2019 Category: Drugs & Pharmacology Authors: Kim SK, Kim KI, Kim SR Tags: Yakugaku Zasshi Source Type: research

[Inhibition of Group IVA Phospholipase A2 as a Novel Therapeutic Strategy for Nonalcoholic Steatohepatitis].
Abstract Nonalcoholic steatohepatitis (NASH) is a lifestyle-related disease characterized by hepatic fibrosis with the accumulation of fat and inflammation and can progress to cirrhosis or hepatocellular carcinoma. However, effective pharmacotherapeutic strategies for hepatic fibrosis in NASH remain to be established. Among the initiators of inflammation, we have been investigating the possible involvement of group IVA phospholipase A2 (IVA-PLA2), which catalyzes the initial step in the generation of lipid mediators, including eicosanoids and lysophospholipids, in the progression of hepatic fibrosis. We have recen...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 3, 2019 Category: Drugs & Pharmacology Authors: Akiba S, Kawashita E, Ishihara K Tags: Yakugaku Zasshi Source Type: research

[Role of Angiogenesis and Chronic Inflammation in Fat Hypertrophy in NASH Pathology].
Abstract Tissue expansion and chronic inflammation in adipose tissue (AT) are closely related to nonalcoholic steatohepatitis (NASH) pathology. Angiogenesis is initiated by the detachment of pericytes (PCs) from vessels in AT. This process is necessary for the development of AT in obesity. The detachment is caused by excessive platelet-derived growth factor B (PDGF-B) derived from M1-macrophages (Mφ) infiltrating obese AT. On the other hand, AT of tamoxifen-induced systemic PDGF receptor-β knockout mice showed decreased detachment of PCs from vessels in obesity, thereby attenuating hypertrophy of AT media...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 3, 2019 Category: Drugs & Pharmacology Authors: Wada T, Tsuneki H, Sasaoka T Tags: Yakugaku Zasshi Source Type: research

[Involvement of the Free Fatty Acid Receptor GPR120/FFAR4 in the Development of Nonalcoholic Steatohepatitis].
In this study, we investigated the involvement of the G-protein-coupled receptor 120/free fatty acid receptor 4 (GPR120/FFAR4) in the pathogenesis of NASH. Mice fed a 0.1% methionine- and choline-deficient l-amino acid-defined, high-fat (CDAHF) diet showed a significant increase in plasma aspartate aminotransferase and alanine aminotransferase levels, fatty deposition, inflammatory cell infiltration, and slight fibrosis. Docosahexanoic acid (DHA, a GPR120/FFAR4 agonist) suppressed the inflammatory cytokines in hepatic tissues and prevented liver fibrosis. On the other hand, GPR120/FFAR4-deficient CDAHF-fed mice showed incr...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 3, 2019 Category: Drugs & Pharmacology Authors: Nakamoto K, Tokuyama S Tags: Yakugaku Zasshi Source Type: research

[A Retrospective Evaluation of the Impact of Multi-disciplinary Approach for Improving the Quality of Anticoagulation Therapy in Ambulatory Patients with Non-valvular Atrial Fibrillation Receiving Warfarin].
Abstract While percent time within therapeutic range (%TTR) of international normalized ratio of prothrombin time (PT-INR) represents the quality of anticoagulation therapy with warfarin, it is often maintained less than 50% in patients with non-valvular atrial fibrillation (NVAF). We aimed to study if implementation of a multi-disciplinary ambulatory anticoagulation service (MAAS) may improve %TTR. Collaborating with cardiologists at Kanto Rosai Hospital, we conducted a MAAS for NVAF patients receiving warfarin from April 2013 to December 2015. Patients who agreed to utilize the service in addition to their appoi...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 3, 2019 Category: Drugs & Pharmacology Authors: Ohgushi A, Nakayama N, Namiki A, Nagashima A, Ogawa R, Akazawa M, Echizen H Tags: Yakugaku Zasshi Source Type: research

[Improvement of the Non-aqueous Titration Method in the Japanese Pharmacopoeia for a Purpose of Advancement in Experimental Safety Using Alternative Solvents].
In this study, we attempted to improve the non-aqueous titration method using N,N-dimethylformamide (DMF) in the Japanese Pharmacopoeia seventeenth edition (JP XVII) for advancement in experimental safety. As an alternative solvent for DMF, we demonstrate titrations using dimethyl sulfoxide (DMSO), which has similar properties as and much higher safety than DMF. Five drugs (i.e., acetohexamide, glibenclamide, sulfamethoxazole, tranilast, and furosemide) listed in JP XVII use DMF as a solvent for titrations with sodium hydroxide standard solution. For these drugs, we examined whether DMF can be replaced with DMSO in quantit...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 3, 2019 Category: Drugs & Pharmacology Authors: Okumura N, Kawanami K, Taniguchi M, Tomabechi A, Takeuchi T, Kitamura Y, Uno B Tags: Yakugaku Zasshi Source Type: research

[Educational Effect of Practical Training on Students' Robust Acquisition and Reconstruction of Expertise on Pharmaceutical Sciences They Had Learned before Practical Training].
Abstract Long-term practical training in the 6-year course of pharmaceutical education is a program for students after acquiring basic knowledge on pharmaceutical sciences and preclinical training. However, it remains unproved whether practical training affects students' robust acquisition and reconstruction of pharmaceutical expertise which they had learned before starting practical training. To address this issue, we administered survey questionnaires to 5th-year students (n=149) of Keio University in 2016 both before and after practical training. From the viewpoint of self-efficacy, psychological approach was a...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 3, 2019 Category: Drugs & Pharmacology Authors: Kikuyama F, Suzuki S, Nakamura T Tags: Yakugaku Zasshi Source Type: research

[Development of High-resolution Methods for the Analysis of Drug Distribution in Biological Tissue Samples and Their Applications].
Abstract The abuse of drugs has become a serious social problem worldwide. Amphetamine-type stimulants such as methamphetamine are recreationally abused and can cause toxic effects in the body. Unfortunately, death from drug poisoning can occur due to careless intake. In postmortem examinations, the distribution of drugs in an entire organ gives valuable information for evaluating their toxicity. We developed methods to measure the distribution of drugs in organs using LC/MS and matrix-assisted laser desorption/ionization-imaging mass spectrometry (MALDI-IMS). The complementary use of the two methods provides more...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 3, 2019 Category: Drugs & Pharmacology Authors: Kuwayama K Tags: Yakugaku Zasshi Source Type: research

[Academic Detailing Leading to Optimal Prescription: Supporting Prescription with Basic Pharmaceutical Sciences and Evidence].
PMID: 31366840 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 3, 2019 Category: Drugs & Pharmacology Authors: Komoda M, Yamamoto M Tags: Yakugaku Zasshi Source Type: research

[Significance and Role of Academic Detailing for Optimal Medication].
Abstract "Academic detailing" is used to clearly explain scientific issues. In the field of clinical practice, "academic detailing" is a form of interactive educational outreach to physicians in order to provide unbiased, non-commercial, evidence-based information about medications and other therapeutic modalities, with the goal of improving patient care. It is necessary to provide proper information about prescription drugs for their appropriate use in clinical practice. However, this requires of physicians significant time and labor to comprehensively collect and summarize all necessary infor...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 3, 2019 Category: Drugs & Pharmacology Authors: Yamamoto M, Hirosawa I, Doi H Tags: Yakugaku Zasshi Source Type: research

[Expectation for Academic Detailing by Pharmacists].
Abstract These days, the necessity of a multidisciplinary approach to cancer patients is well known. However, not all cancer patients are satisfied with their medical care. One reason for this is the difficulty integrating all the specialties required in order to provide individualized care that considers the needs of each patient. To achieve the best medical care, each specialist in any multidisciplinary teams needs to be a leader when it comes to his or her own specialty, to communicate with each other to share all the information available, and to apply evidence-based medicine considering each patient's physica...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 3, 2019 Category: Drugs & Pharmacology Authors: Saito M Tags: Yakugaku Zasshi Source Type: research

[Practice Examples of Academic Detailing -Prescription Support Based on Basic Pharmaceutical Science and Evidence].
Abstract Better prescription assistance can be provided by applying basic pharmaceutical science concepts, and by considering evidence from clinical trials. For example, several drugs are currently used to treat ulcerative colitis (UC), a form of inflammatory bowel disease. In general, after a drug is administered, it is first absorbed into the upper part of the small intestine and then enters the bloodstream. However, 5-aminosalicylic acid (5-ASA), which is commonly used to treat UC, acts locally on the colonic mucosa; its absorption must be prevented in the upper gastrointestinal tract so that it can be delivere...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 3, 2019 Category: Drugs & Pharmacology Authors: Sato M, Hirata J, Shibahara Y Tags: Yakugaku Zasshi Source Type: research

[What Is Medical Science Liaison?]
Abstract Currently, the role of medical representative (MR) is responsible for providing information to medical doctors from pharmaceutical/medical equipment companies. In recent years, however, the newer role of medical science liaison (MSL) has been established to construct evidence and provide advanced medical and scientific information to health care professionals. This position, independent from the sales division of a pharmaceutical or medical equipment company, has already been established in Europe and the U.S. The MSL helps to combat concerns of conflicts of interest (COI) concerning the sophistication of...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 3, 2019 Category: Drugs & Pharmacology Authors: Sasaki M Tags: Yakugaku Zasshi Source Type: research

[Expectations of an Academic Detailer from a Pharmaceutical Industry Perspective].
Abstract In the pharmaceutical industry, a Medical Affairs ("MA") professional collects, organizes and transmits information about a health care product based on the judgment of science, medicine and ethical values, thereby optimizing the product's value, improving corporate value, and assuring quality medical care. The role of the MA is to construct a "medical strategy" through the process of collecting, analyzing and evaluating information. On the other hand, Academic Detailing is "a new approach to drug information that actively disseminates drug comparison information from a pharmacolo...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 3, 2019 Category: Drugs & Pharmacology Authors: Taruno H Tags: Yakugaku Zasshi Source Type: research

[Academic Detailing from the Viewpoint of Chemical Structural Formulas].
Abstract In order to implement academic detailing, it is extremely important to understand the pharmacological activity of drugs based on their chemical structures. To construct a database for academic detailing, a viewpoint for clinically utilizing the fundamental pharmacological features of a drug is required. These fundamental pharmacological features include chemical characteristics such as chemical structures, physical characteristics such as pharmaceutical formulations for efficient drug delivery to target organs, and a pharmacological viewpoint, which is a mechanism by which a drug is determined to be effec...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 3, 2019 Category: Drugs & Pharmacology Authors: Wada T Tags: Yakugaku Zasshi Source Type: research

[What Is Involved in the Training Program for a Japanese Academic Detailer?]
Abstract 'Academic Detailing' is an approach to providing doctors with information about medicines based on the latest non-commercial evidence-based data for proper prescription. Overseas, pharmacists have been active as academic detailers. Academic Detailing in Japan, as a new approach to disseminating comparative drug information based on basic pharmaceutical sciences and clinical evidence, will influence clinical decision making by doctors, and contribute to better patient-centered medical care. Pharmacists have been participating in ensuring the proper use of drugs by their patients by entering their homes or ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 3, 2019 Category: Drugs & Pharmacology Authors: Komoda M, Negishi K, Mano Y, Ozeki R, Goto K Tags: Yakugaku Zasshi Source Type: research

[Development of Novel Genotyping Protocol and Its Application for Genotyping of Alcohol Metabolism-related Genes].
Abstract A new single nucleotide polymorphisms (SNP) genotyping method has been developed and validated using biological specimens directly as templates for TaqMan PCR without general DNA extraction and purification procedure from dried saliva samples attached on water-soluble papers. This new method can set up at ease and complete PCR analysis including data interpretation in under two hours with additional advantages of application for large-scale clinical research, diagnostics, and epidemiological studies at low cost. Specifically, SNP genotyping of alcohol metabolism-related genes ADH1B (rs1229984) and ALDH2 (...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 3, 2019 Category: Drugs & Pharmacology Authors: Imai M, Kisoi M, Sakaguchi Y, Yamamura M, Kawai S, Murata S, Ichikawa A, Kinoshita K Tags: Yakugaku Zasshi Source Type: research

[Evaluation of Rheological Properties of Cohesive Ophthalmic Viscosurgical Devices Composed of Sodium Hyaluronate with High Molecular Weight-2019].
In conclusion, we demonstrated that each OVD has particular rheological properties within the range of the product specification defined by the intrinsic viscosity. The results might provide useful information for surgeons in their selection of OVDs based on their experience. PMID: 31366849 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 3, 2019 Category: Drugs & Pharmacology Authors: Watanabe I, Mirumachi H, Konno H, Suzuki K Tags: Yakugaku Zasshi Source Type: research

[Prion-like Propagation of Pathological α-Synuclein in Vivo].
[Prion-like Propagation of Pathological α-Synuclein in Vivo]. Yakugaku Zasshi. 2019;139(7):1007-1013 Authors: Masuda-Suzukake M, Hasegawa M Abstract α-Synuclein (αS) is the major component of the filamentous inclusions that constitute the defining characteristic of neurodegenerative synucleinopathies, including Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. αS is deposited in a hyperphosphorylated and ubiquitinated form with a β-sheet-rich fibrillar structure in diseased brains. In 2008, some researchers reported that embryonic neurons transpl...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2019 Category: Drugs & Pharmacology Authors: Masuda-Suzukake M, Hasegawa M Tags: Yakugaku Zasshi Source Type: research

[Prion-like Properties of Misfolded Cu/Zn-superoxide Dismutase in Amyotrophic Lateral Sclerosis: Update and Perspectives].
Abstract Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease that is characterized by the loss of motor neurons, which results in progressive muscle atrophy. The pathology spreads from the initial site of onset to contiguous anatomic regions. Mutations in the gene encoding Cu/Zn-superoxide dismutase (SOD1) have been identified in a dominantly inherited form of ALS (ALS-SOD1). A major hallmark of ALS-SOD1 is the abnormal accumulation of conformationally aberrant SOD1 protein (i.e., misfolded SOD1) within motor neurons. Emerging experimental evidence has suggested that misfolded proteins associ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2019 Category: Drugs & Pharmacology Authors: Tokuda E, Marklund SL, Furukawa Y Tags: Yakugaku Zasshi Source Type: research

[Prion-like Propagation Model of Tau].
Abstract Abnormal proteins such as tau or α-synuclein that accumulate in brains with dementia have been shown to propagate like prion proteins. However, the expression patterns of tau in the mouse brain are different from those in humans, and the pathogenesis in the animal model of abnormal tau propagation remains incompletely understood. To overcome this problem, a novel mouse showing tau expression patterns similar to those of humans was developed using genome editing techniques. We inoculated the brain of this mouse with a sarkosyl-insoluble fraction containing abnormal tau derived from tauopathy patients...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2019 Category: Drugs & Pharmacology Authors: Hosokawa M, Hasegawa M Tags: Yakugaku Zasshi Source Type: research

[Complementary and Alternative Medicine for Breast Cancer Patients: An Overview of Systematic Reviews].
In conclusion, since most SRs were at moderate or high quality levels, CAM could be helpful for treating specific symptoms related to breast cancer. PMID: 31257250 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2019 Category: Drugs & Pharmacology Authors: Sasaki Y, Cheon C, Motoo Y, Jang S, Park S, Ko SG, Jang BH, Hwang DS Tags: Yakugaku Zasshi Source Type: research

[Improvements in Lifestyle from a Lifestyle Consecutive Self-Review at a Pharmacy].
This study tests such a service at a pharmacy. We prepared a lifestyle self-review test. From September 2015 to February 2016, pharmacists interviewed members of the community using the test, and pharmacists at 50 pharmacies in Aichi prefecture, Japan, set goals for lifestyle improvement. We analyzed 289 tests. The number of people who had a dietary goal concerning snacking was reduced from 19 people who snacked every day to 11. The number of people who had a goal to reduce their drinking was reduced from 7 people who drank every day to 4. The number of people who had an exercise goal was reduced from 17 people who did not...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2019 Category: Drugs & Pharmacology Authors: Suzuki R, Suzuki T, Kikuchi C Tags: Yakugaku Zasshi Source Type: research

[Verification of Relationship between Administration of Linezolid and Vomiting].
In this study, we aimed to verify the relationship between LZD administration and vomiting. Patients administered LZD at the Department of Orthopedic Surgery of Hokkaido University Hospital between November 2008 and December 2017 were enrolled in the study. The primary endpoint was the comparison of the vomiting rate between patients administered LZD (LZD group) and those administered other antibiotics (non-LZD group). For the secondary endpoint, to verify the risk factors of vomiting, a univariate logistic regression analysis was performed. In total, 130 patients were included in this study; 77 patients in the LZD group, ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2019 Category: Drugs & Pharmacology Authors: Tsutsumi T, Imai S, Yamada K, Yamada T, Kasashi K, Kobayashi M, Iseki K Tags: Yakugaku Zasshi Source Type: research

[Contributions to the Establishment and Promotion of Pharmacy Education Reform].
Abstract In 2006, four-year pharmacist training courses in Japanese pharmacy schools were extended to a six-year course. Around that time, I participated in a committee related to pharmacy education reform within the Ministry of Education, Culture, Sports, Science and Technology. I also joined the pharmacist division of the medical council of the Ministry of Health, Labour and Welfare, to reform the national pharmacist examination system. In addition, I was part of the Pharmacy Education Council responsible for developing the contents of the new six-year curriculum, especially for clinical training. In the process...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2019 Category: Drugs & Pharmacology Authors: Hirai M Tags: Yakugaku Zasshi Source Type: research

[Structural Basis of the Multifunctional Hub Protein and Identification of a Small-molecule Compound for Drug Discovery].
Abstract Translesion DNA synthesis (TLS) is an emergency system activated to inhibit cell death caused by DNA damage-induced replication arrest. Thus, TLS enables cancer cells to acquire resistance to alkylate anticancer drugs. REV7 functions as the hub protein that interacts with both the inserter DNA polymerase REV1 and the extender DNA polymerase REV3 in TLS. REV7-mediated protein-protein interactions (PPIs) are essential for the activation of TLS, and are therefore attractive targets for anticancer drug development. To clarify the REV7-REV3 and REV7-REV1 PPIs, we determined the structures of REV7-REV3 and REV7...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2019 Category: Drugs & Pharmacology Authors: Hara K Tags: Yakugaku Zasshi Source Type: research

[Development of External Stimuli-responsive Organic π Molecules and the Creation of Novel Photo-functions].
[Development of External Stimuli-responsive Organic π Molecules and the Creation of Novel Photo-functions]. Yakugaku Zasshi. 2019;139(7):975-986 Authors: Kamino S Abstract We have found that the spiro form of aminobenzopyranoxanthene (ABPX) exhibits dual solvatochromic and nanoaggregate fluorescence in organic solvents by spectrophotometric and theoretical analyses. The dual fluorescence properties of ABPX were adjustable in response to water content, and served as a new detection principal for naked-eye visualization (above 0.5 wt%) and quantification (0.010-0.125 wt%) of water in tetrahydrofuran....
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2019 Category: Drugs & Pharmacology Authors: Kamino S Tags: Yakugaku Zasshi Source Type: research

[Prion and Prion-like Proteins].
PMID: 31257256 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2019 Category: Drugs & Pharmacology Authors: Sano K, Hosokawa M Tags: Yakugaku Zasshi Source Type: research

[Elucidation of the Molecular Basis of Abnormal Prion Protein (PrP) Formation in a Cell-Free System Using Baculovirus and Insect Cell-derived Recombinant PrP].
Abstract The molecular basis underlying the conversion of normal prion protein (PrPC) into abnormal prion protein (PrPSc) has not been fully elucidated. The protein-misfolding cyclic amplification (PMCA) technique, which can amplify PrPSc in vitro with the use of intermittent sonication, mimics the process of in vivo PrPSc replication. Accumulating evidence suggests that co-factors other than PrP may play a crucial role in the faithful replication of PrPSc. In conventional PMCA, brain homogenates (BHs) from normal animals are used as the PrPC substrate. Since BHs contain many impurities, it is difficult to identif...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2019 Category: Drugs & Pharmacology Authors: Imamura M, Mori T, Takatsuki H, Iwamaru Y, Atarashi R Tags: Yakugaku Zasshi Source Type: research

[Protective Role of the Host Innate Immune System in Prion Pathogenesis].
Abstract Prion diseases, including human Creutzfeldt-Jakob disease, are infectious, intractable central neurodegenerative diseases, which are also zoonoses that commonly infect not only higher organisms but also a wide variety of animals. Pathogenic prions induce abnormal prion protein (PrP), which is produced by structural conversion of normal PrP, a beta-sheet-rich structure with high aggregation propensity. Thus, it is believed that the host is immunotolerant against prions because there is no difference in the primary structure of normal and abnormal PrP, and prions do not induce a marked immune response. Rece...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2019 Category: Drugs & Pharmacology Authors: Ishibashi D Tags: Yakugaku Zasshi Source Type: research

[Real-time Quaking-induced Conversion Analysis of Prion-like Seeding Activity of Pathological α-Synuclein].
We examined whether brain tissues from cases of dementia with Lewy bodies (DLB), which contain serine 129 (Ser129)-phosphorylated insoluble aggregates of αSyn, exhibit prion-like seeding activity in vitro using the real-time quaking-induced conversion (RT-QuIC) seeding assay. Brain tissues from cases of diffuse neocortical DLB yielded a 50% seeding dose of 107.3-109.8/g brain. The RT-QuIC assay could discriminate between DLB and other neurological and neurodegenerative disorders, suggesting its potential applicability for differential diagnosis. Insoluble aggregates of αSyn>250 kDa detected only in DLB brain...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2019 Category: Drugs & Pharmacology Authors: Sano K Tags: Yakugaku Zasshi Source Type: research

[Clinical Research on the Effects of Differences in Properties of External Preparations for Skin on Application Amount: An Exploratory Investigation of the Relationship between the Base Usability and Application Amount by Questionnaire in Adult Subjects].
In this study, we investigated the usability and application amount of three bases with different properties (ointment base, cream base, and lotion base) in 62 adult subjects and exploratively examined the effect of the different base properties on the application amount. The results of this clinical study showed that the usability and preference for the base used for external preparations varies, and poor usability and low preference may lead to a reduction in the application amount. Even with good usability and high preference, there were many cases in which an adequate amount was not applied due to lack of specific inst...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 21, 2019 Category: Drugs & Pharmacology Authors: Nakahigashi H, Numazaki T, Nakamura H, Yoshioka D, Ashizuka Y, Yoshimune R, Honda N Tags: Yakugaku Zasshi Source Type: research

[Comparison of the Pharmaceutical Characteristics of Brand-name and Generic Pramipexole Extended-release Tablets and their PTP Package Usability].
In this study we examined the stability of tablets in the ODP (25℃ RH75%) while also comparing the ease of handling of the seven products currently marketed in Japan. In the tablets' ODP, changes such as swelling and decreases in tablets hardness were observed in six formulations. Differences were found among the products in comparison of packaging material, required tablet extrusion strength, and ease of removal. Given the differences in PTP materials and hygroscopicity it is suggested that pharmacists must not only consider the drug formulations of products but also contribute to improvements in medication adherence fo...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 13, 2019 Category: Drugs & Pharmacology Authors: Akiyama S, Maida C, Miyamoto E, Doi N Tags: Yakugaku Zasshi Source Type: research

[The Involvement of Src in Airway Inflammation Induced by Repeated Exposure to Lipopolysaccharide in Mice].
Abstract Corticosteroid insensitive airway inflammation is one of major barrier to effective managements of chronic airway diseases, such as obstructive pulmonary airway disease (COPD) and severe asthma. The role of nonreceptor tyrosine kinase Src is important in airway inflammation in mice models of atopic asthma and COPD. Thus, in this study, we determined the effects of Src inhibitor, dasatinib, on airway inflammation induced by repeated intranasal exposure to lipopolysaccharide (LPS). Male mice (A/J strain, 5 weeks old) were intranasally exposed to LPS twice daily for 3 days, and dasatinib was intranasally tre...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 13, 2019 Category: Drugs & Pharmacology Authors: Nishimoto Y, Yasuda H, Masuko K, Usui Y, Ueda K, Kimura G, Ito K, Kizawa Y Tags: Yakugaku Zasshi Source Type: research

[Elucidation of the Mechanisms Underlying Regulation of Somatic Stem Cell Function: Possible Application to the Treatment of Neuropsychiatric, Metabolic Bone, and Lifestyle Diseases].
PMID: 31155523 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2019 Category: Drugs & Pharmacology Authors: Nakamichi N, Takarada T Tags: Yakugaku Zasshi Source Type: research

[Possible Treatment of Neuropsychiatric Disorders by Promotion of Neuronal Differentiation through Organic Cation Transporters].
Abstract Neurons differentiated from neural stem cells mature to form a neuronal network. Neuronal maturation enables neurotransmission that regulates brain function. Therefore, abnormal neuronal differentiation causes dysfunction in neurotransmission, and is involved in the onset of various neuropsychiatric disorders. Most of the drugs currently available for the treatment of neuropsychiatric disorders act on membrane receptors and reuptake transporters of neurotransmitters, and control neurotransmission. These membrane proteins have a high affinity for a specific neurotransmitter, and are highly expressed in syn...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2019 Category: Drugs & Pharmacology Authors: Nakamichi N, Masuo Y, Kato Y Tags: Yakugaku Zasshi Source Type: research

[Adult Neurogenesis-activating Signals as Therapeutic Targets for Neurodegenerative Disorders].
Abstract In most mammalian species, adult neurogenesis appears to occur only in the olfactory bulb and hippocampal dentate gyrus, where neural stem/progenitor cells exist to create new neurons. The discovery of multi-potential neural stem/progenitor cells (NPCs) in the adult brain has precipitated a novel therapeutic strategy for harnessing these endogenous cells to aid in recovery from neurodegenerative disorders. During neurodegeneration, a plethora of endogenous factors, including cytokines, chemokines, neurotransmitters, blood-derived factors, and reactive oxygen species, are released by the activation of resi...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2019 Category: Drugs & Pharmacology Authors: Yoneyama M, Ogita K Tags: Yakugaku Zasshi Source Type: research

[Evaluation of Naturally Occurring Compounds Regulating Brown/Beige Adipocyte Differentiation].
Abstract Brown adipose tissue is a critical regulator of metabolic health, and contributes to thermogenesis by uncoupling oxidative phosphorylation through the action of mitochondrial uncoupling protein 1 (Ucp1). Recent studies have shown that cold exposure and the stimulation of β3-adrenergic receptors induce the development of brown cell-like "beige" adipocytes in white adipose tissue. Brown and/or beige adipocyte-mediated thermogenesis suppresses high-fat diet-associated obesity. Therefore, the development of brown/beige adipocytes may prevent obesity and metabolic diseases. In the present study,...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2019 Category: Drugs & Pharmacology Authors: Hirai T, Takagi M, Nakashima KI, Inoue M Tags: Yakugaku Zasshi Source Type: research