Molecules, Vol. 24, Pages 3399: Corilagin in Cancer: A Critical Evaluation of Anticancer Activities and Molecular Mechanisms
Abhay K. Pandey Corilagin (β-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-d-glucose), an ellagitannin, is one of the major bioactive compounds present in various plants. Ellagitannins belong to the hydrolyzable tannins, a group of polyphenols. Corilagin shows broad-spectrum biological, and therapeutic activities, such as antioxidant, anti-inflammatory, hepatoprotective, and antitumor actions. Natural compounds possessing antitumor activities have attracted significant attention for treatment of cancer. Corilagin has shown inhibitory activity against the growth of numerous cancer cells by prompting cell cycle...
Source: Molecules - September 19, 2019 Category: Chemistry Authors: Ashutosh Gupta Amit Kumar Singh Ramesh Kumar Risha Ganguly Harvesh Kumar Rana Prabhash Kumar Pandey Gautam Sethi Anupam Bishayee Abhay K. Pandey Tags: Review Source Type: research

Molecules, Vol. 24, Pages 3400: Petroleum Hydrocarbon Contamination in Terrestrial Ecosystems —Fate and Microbial Responses
Molecules, Vol. 24, Pages 3400: Petroleum Hydrocarbon Contamination in Terrestrial Ecosystems—Fate and Microbial Responses Molecules doi: 10.3390/molecules24183400 Authors: Adam Truskewycz Taylor D. Gundry Leadin S. Khudur Adam Kolobaric Mohamed Taha Arturo Aburto-Medina Andrew S. Ball Esmaeil Shahsavari Petroleum hydrocarbons represent the most frequent environmental contaminant. The introduction of petroleum hydrocarbons into a pristine environment immediately changes the nature of that environment, resulting in reduced ecosystem functionality. Natural attenuation represents the single, most i...
Source: Molecules - September 19, 2019 Category: Chemistry Authors: Adam Truskewycz Taylor D. Gundry Leadin S. Khudur Adam Kolobaric Mohamed Taha Arturo Aburto-Medina Andrew S. Ball Esmaeil Shahsavari Tags: Review Source Type: research

Molecules, Vol. 24, Pages 3401: Castanea sativa Mill. Shells Aqueous Extract Exhibits Anticancer Properties Inducing Cytotoxic and Pro-Apoptotic Effects
In conclusion, these outcomes suggested that CS might be used for the extraction of several polyphenols that may represent good candidates for alternative therapies or in combination with current chemotherapeutics. (Source: Molecules)
Source: Molecules - September 19, 2019 Category: Chemistry Authors: Nunzio Antonio Cacciola Giuseppe Squillaci Mariella D ’Apolito Orsolina Petillo Francesco Veraldi Francesco La Cara Gianfranco Peluso Sabrina Margarucci Alessandra Morana Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3402: Fractionated Antioxidant and Anti-inflammatory Kernel Oil from Torreya fargesii
In this study, a typical PMI-PUFA, sciadonic acid (C20:3, 5c 11c 14c), was enriched in the kernel oil of Torreya fargesii (T. fargesii) by fractionation. Fractionated kernel oil of T. fargesii (containing 25% sciadonic acid) showed equal stability and similar radical scavenging ability compared with the non-fractionated oil. In anti-inflammatory tests, fractionated kernel oil was shown to inhibit the activity of phosphodiesterase (PDE-5, efficiency 80% at 133.7 μg/mL) and lipoxygenase-5 (LOX-5, efficiency 65% at 66.7 μg/mL) more effectively than the non-fractionated oil. This shows that increasing the...
Source: Molecules - September 19, 2019 Category: Chemistry Authors: Xianrong Zhou Jin Shang Mingyi Qin Jianhua Wang Bo Jiang Hui Yang Yan Zhang Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3403: Deepening Inside the Pictorial Layers of Etruscan Sarcophagus of Hasti Afunei: An Innovative Micro-Sampling Technique for Raman/SERS Analyses
Maurizio Bruno The Hasti Afunei sarcophagus is a large Etruscan urn, made up of two chalky alabaster monoliths. Dated from the last quarter of the third century BC, it was found in 1826 in the small town of Chiusi (Tuscany- Il Colle place) by a landowner, Pietro Bonci Casuccini, who made it part of his private collection. The noble owner’s collection was sold in 1865 to the Royal Museum of Palermo (today under the name of Antonino Salinas Regional Archaeological Museum), where it is still displayed. The sarcophagus is characterized by a complex iconography that is meticulously illustrated through an exce...
Source: Molecules - September 19, 2019 Category: Chemistry Authors: Rossella Gagliano Candela Livia Lombardi Alessandro Ciccola Ilaria Serafini Armandodoriano Bianco Paolo Postorino Lorella Pellegrino Maurizio Bruno Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3405: Michaelis-Arbuzov-Type Reaction of 1-Imidoalkyltriarylphosphonium Salts with Selected Phosphorus Nucleophiles
In this study, Michaelis-Arbuzov-type reaction of 1-imidoalkyltriarylphosphonium salts with phosphites, phosphonites, and phosphinites was used in the synthesis of a wide range of phosphorus analogs of α-amino acids such as 1-imidoalkylphosphonates, 1-imidoalkylphosphinates, and 1-imidoalkylphosphine oxides. Large differences were observed in the reactivity of substrates depending on their structure, especially on the type of phosphonium moiety and N-protecting group. The conditions under which the expected products can be obtained in good to excellent yields have been developed. Mechanistic aspects of the tr...
Source: Molecules - September 19, 2019 Category: Chemistry Authors: Jakub Adamek Anna W ęgrzyk-Schlieter Klaudia Ste ć Krzysztof Walczak Karol Erfurt Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3406: E-Beam Irradiation and Ozonation as an Alternative to the Sulphuric Method of Wine Preservation
The objective of the present study was to assess the efficiency of ozonation and ionizing radiation as alternatives to wine sulphurization. The efficiency of yeast removal and the retention of the chemical quality of wine were evaluated. Wine was subjected to 60 min of ozonation, and radiation doses were set at 1–10 kGy. Moreover, a combination of ozonation and ionizing radiation treatment was used. The ozonation of wine did not produce the expected results. That is, it did not limit the number of yeast cells. From the sixth minute, a significant deterioration in the taste and the color of the wine was found....
Source: Molecules - September 19, 2019 Category: Chemistry Authors: Magdalena B łaszak Agata Nowak Sabina Lachowicz Wojciech Migda ł Ireneusz Ochmian Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3408: Water Extraction Kinetics of Bioactive Compounds of Fucus vesiculosus
Rui Costa Brown macroalgae, particularly those from Fucus genus, are a rich and balanced source of bioactive nutrients and phytochemicals, such as dietary fibres (fucoidans, laminarins, and/or alginates), phlorotannins, and fucoxanthin, and some minerals, such as iodine, which have been demonstrated to possess numerous health-promoting properties. In fact, aqueous extracts of Fucus vesiculosus have been used as food supplements due to its rich content in bioactive compounds, though no study has been published on the optimization of this operation. Therefore, this study aimed to evaluate the impact of different extrac...
Source: Molecules - September 19, 2019 Category: Chemistry Authors: Ricardo M. Ferreira Ana Ramalho Ribeiro Carla Patinha Artur M. S. Silva Susana M. Cardoso Rui Costa Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3409: Drug Repurposing as an Antitumor Agent: Disulfiram-Mediated Carbonic Anhydrase 12 and Anion Exchanger 2 Modulation to Inhibit Cancer Cell Migration
In conclusion, the attenuation of AE2 and its supportive enzyme CA12, and the inhibitory effect on cell migration by Disulfiram treatment in cancer cells provided the molecular evidence supporting the potential of Disulfiram as an anticancer agent. (Source: Molecules)
Source: Molecules - September 19, 2019 Category: Chemistry Authors: Soyoung Hwang Dong Min Shin Jeong Hee Hong Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3407: Targeted Delivery of Plasminogen Activators for Thrombolytic Therapy: An Integrative Evaluation
Tony Wu In thrombolytic therapy, plasminogen activators (PAs) are still the only group of drug approved to induce thrombolysis, and therefore, critical for treatment of arterial thromboembolism, such as stroke, in the acute phase. Functionalized nanocomposites have attracted great attention in achieving target thrombolysis due to favorable characteristics associated with the size, surface properties and targeting effects. Many PA-conjugated nanocomposites have been prepared and characterized, and some of them has been demonstrated with therapeutic efficacy in animal models. To facilitate future translation, this pape...
Source: Molecules - September 19, 2019 Category: Chemistry Authors: Yunn-Hwa Ma Chih-Hsin Liu Yueh Liang Jyh-Ping Chen Tony Wu Tags: Review Source Type: research

Molecules, Vol. 24, Pages 3404: Synthesis, Characterization and Solubility Determination of 6-Phenyl-pyridazin-3(2H)-one in Different Pharmaceutical Solvents
lid Anwer The current research work proposed the solubility data and solution thermodynamic properties of the cardiovascular agent 6-phenylpyridazin-3(2H)-one [PPD] in twelve pharmaceutical solvents at “T = 298.2 K to 318.2 K” and “p = 0.1 MPa”. The measured solubilities of PPD were regressed well with “van’t Hoff and Apelblat models”. The solid phases of pure and equilibrated PPD were characterized using differential scanning calorimetry and powder X-ray differactometry, and the results suggested no transformation of PPD ...
Source: Molecules - September 19, 2019 Category: Chemistry Authors: Faiyaz Shakeel Mohd Imran Nazrul Haq Sultan Alshehri Md. Khalid Anwer Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3410: Nano-and Micromotors Designed for Cancer Therapy
gdanz Research on nano- and micromotors has evolved into a frequently cited research area with innovative technology envisioned for one of current humanities’ most deadly problems: cancer. The development of cancer targeting drug delivery strategies involving nano-and micromotors has been a vibrant field of study over the past few years. This review aims at categorizing recent significant results, classifying them according to the employed propulsion mechanisms starting from chemically driven micromotors, to field driven and biohybrid approaches. In concluding remarks of section 2, we give an insight into...
Source: Molecules - September 19, 2019 Category: Chemistry Authors: Luisa Sonntag Juliane Simmchen Veronika Magdanz Tags: Review Source Type: research

Molecules, Vol. 24, Pages 3411: Non-Enzymatic Electrochemical Sensor Based on Sliver Nanoparticle-Decorated Carbon Nanotubes
odong Liu The authors report a non-enzymatic electrochemical sensor based on a sliver nanoparticle-decorated carbon nanotube (AgNPs-MWCNT). Highly-dispersed AgNPs were loaded on the MWCNT surface though a simple and facile two-step method. The morphology, components, and the size of the AgNPs-MWCNT nanocomposite were characterized by transmission electron microscopy, X-ray diffraction, and ICP analysis. Benefitting from the synergistic effect between the AgNPs and MWCNT, the AgNPs-MWCNT nanocomposite exhibited high electrocatalytic activity for H2O2; the AgNPs-MWCNT electrochemical sensor was prepared by coating the Ag...
Source: Molecules - September 19, 2019 Category: Chemistry Authors: Dongqing Xu Bingbing Hou Lisheng Qian Xueji Zhang Guodong Liu Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3412: Advances in the Asymmetric Total Synthesis of Natural Products Using Chiral Secondary Amine Catalyzed Reactions of α,β-Unsaturated Aldehydes
Molecules, Vol. 24, Pages 3412: Advances in the Asymmetric Total Synthesis of Natural Products Using Chiral Secondary Amine Catalyzed Reactions of α,β-Unsaturated Aldehydes Molecules doi: 10.3390/molecules24183412 Authors: Zhonglei Wang Chirality is one of the most important attributes for its presence in a vast majority of bioactive natural products and pharmaceuticals. Asymmetric organocatalysis methods have emerged as a powerful methodology for the construction of highly enantioenriched structural skeletons of the target molecules. Due to their extensive application of organocatalysis in the total syn...
Source: Molecules - September 19, 2019 Category: Chemistry Authors: Zhonglei Wang Tags: Review Source Type: research

Molecules, Vol. 24, Pages 3413: Design of Peptidomimetic Functionalized Cholesterol Based Lipid Nanoparticles for Efficient Delivery of Therapeutic Nucleic Acids
a Baigude Lipid nanoparticles (LNP) are the most potent carriers for the delivery of nucleic acid-based therapeutics. The first FDA approved a short interfering RNA (siRNA) drug that uses a cationic LNP system for the delivery of siRNA against human transthyretin (hTTR). However, preparation of such LNP involves tedious multi-step synthesis with relatively low yields. In the present study, we synthesized cationic peptidomimetic functionalized cholesterol (denote Chorn) in straightforward chemical approaches with high yield. When formulated with helper lipids, Chorn LNPs complexed with siRNA to form nanoparticles with a...
Source: Molecules - September 19, 2019 Category: Chemistry Authors: Ehexige Ehexige Tsogzolmaa Ganbold Xiang Yu Shuqin Han Huricha Baigude Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3414: Selectively Charged and Zwitterionic Analogues of the Smallest Immunogenic Structure of Streptococcus Pneumoniae Type 14
enzo Guazzelli Zwitterionic polysaccharides (ZPs) have been shown in recent years to display peculiar immunological properties, thus attracting the interest of the carbohydrate research community. To fully elucidate the mechanisms underlying these properties and exploit the potential of this kind of structures, in depth studies are still required. In this context, the preparation of two cationic, an anionic, as well as two zwitterionic tetrasaccharide analogues of the smallest immunogenic structure of Streptococcus pneumoniae type 14 (SP14) capsular polysaccharide are presented. By exploiting a block strategy, the nega...
Source: Molecules - September 19, 2019 Category: Chemistry Authors: Tiziana Gragnani Doretta Cuffaro Silvia Fallarini Grazia Lombardi Felicia D ’Andrea Lorenzo Guazzelli Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3415: Preparation and Application of Bioshell Calcium Oxide (BiSCaO) Nanoparticle-Dispersions with Bactericidal Activity
Fujita Yokoe Scallop-shell powder (SSP) heated at high temperature exhibits high pH and broad antimicrobial activity. Bioshell calcium oxide (BiSCaO) is an SSP composed mainly of calcium oxide. It is poorly water-soluble under alkaline conditions and the generated precipitate can plug spray nozzles. The aim of this study was to establish that BiSCaO dispersion caused no significant CaO loss and plugging of spray nozzles, and to evaluate its deodorization and microbicidal abilities and its ability to reduce the concentrations of NO2− and NO3−. BiSCaO dispersions were prepared by mixing ...
Source: Molecules - September 19, 2019 Category: Chemistry Authors: Sato Ishihara Nakamura Fukuda Takayama Hiruma Murakami Fujita Yokoe Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3397: A Monte Carlo Method for Determining the Response Relationship between Two Commonly Used Detectors to Indirectly Measure Alpha Particle Radiation Activity
G. Moros Using targeted ligands to deliver alpha-emitting radionuclides directly to tumor cells has become a promising therapeutic strategy. To calculate the radiation dose to patients, activities of parent and daughter radionuclides must be measured. Scintillation detectors can be used to quantify these activities; however, activities found in pre-clinical and clinical studies can exceed their optimal performance range. Therefore, a method of correcting scintillation detector measurements at higher activities was developed using Monte Carlo modeling. Because there are currently no National Institute of Standards and ...
Source: Molecules - September 19, 2019 Category: Chemistry Authors: Christopher J. Tichacek Mikalai M. Budzevich Thaddeus J. Wadas David L. Morse Eduardo G. Moros Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3398: Dual-Purpose Materials Based on Carbon Xerogel Microspheres (CXMs) for Delayed Release of Cannabidiol (CBD) and Subsequent Aflatoxin Removal
This study opens a broader landscape in which to develop dual-purpose materials for the delayed release of CBD, improving its bioavailability and allowing aflatoxin removal in gastric conditions. (Source: Molecules)
Source: Molecules - September 19, 2019 Category: Chemistry Authors: Farid B. Cort és Karol Zapata Benjam ín A. Rojano Francisco Carrasco-Mar ín Jaime Gallego M. Alejandra Hern ández Camilo A. Franco Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3385: Cytotoxicity and Apoptosis Induction of Coumarins and Carbazole Alkaloids from Clausena Harmandiana
In conclusion, xantoxyletin primarily show potential anticancer activity. The root bark of C. harmandiana is a good source of bioactive compounds or the lead for the development of new pharmaceutical agent. (Source: Molecules)
Source: Molecules - September 18, 2019 Category: Chemistry Authors: Porntip Jantamat Natthida Weerapreeyakul Ploenthip Puthongking Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3386: Antifungal Effects and Potential Mechanism of Essential Oils on Collelotrichum gloeosporioides In Vitro and In Vivo
Hao Zhai The development of natural essential oil as an alternative to synthetic chemicals in the control of postharvest decay is currently in the spotlight. In the present study, the efficacy of seven essential oils in suppressing Collelotrichum gloeosporioides identified from sweet cherry was evaluated in vitro and clove oil was proved to be the most promising inhibitor. Thus, the antifungal properties and potential mechanisms of clove oil in vitro and in vivo by fumigation and contact treatments were intensively investigated. For C. gloeosporioides, the minimal inhibitory concentrations (MIC) of clove oil in air an...
Source: Molecules - September 18, 2019 Category: Chemistry Authors: Dan Wang Jing Zhang Xiaoman Jia Li Xin Hao Zhai Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3387: Molecular Docking and Dynamics Simulation of Protein β-Tubulin and Antifungal Cyclic Lipopeptides
Molecules, Vol. 24, Pages 3387: Molecular Docking and Dynamics Simulation of Protein β-Tubulin and Antifungal Cyclic Lipopeptides Molecules doi: 10.3390/molecules24183387 Authors: Nubia Noemi Cob-Calan Luz America Chi-Uluac Filiberto Ortiz-Chi Daniel Cerqueda-García Gabriel Navarrete-Vázquez Esaú Ruiz-Sánchez Emanuel Hernández-Núñez To elucidate interactions between the antifungal cyclic lipopeptides iturin A, fengycin, and surfactin produced by Bacillus bacteria and the microtubular protein β-tubulin in plant pathogenic fungi (Fusarium ...
Source: Molecules - September 18, 2019 Category: Chemistry Authors: Nubia Noemi Cob-Calan Luz America Chi-Uluac Filiberto Ortiz-Chi Daniel Cerqueda-Garc ía Gabriel Navarrete-V ázquez Esa ú Ruiz-Sánchez Emanuel Hern ández-Núñez Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3388: Yeast Models for Amyloids and Prions: Environmental Modulation and Drug Discovery
inson Amyloids are self-perpetuating protein aggregates causing neurodegenerative diseases in mammals. Prions are transmissible protein isoforms (usually of amyloid nature). Prion features were recently reported for various proteins involved in amyloid and neural inclusion disorders. Heritable yeast prions share molecular properties (and in the case of polyglutamines, amino acid composition) with human disease-related amyloids. Fundamental protein quality control pathways, including chaperones, the ubiquitin proteasome system and autophagy are highly conserved between yeast and human cells. Crucial cellular proteins an...
Source: Molecules - September 18, 2019 Category: Chemistry Authors: Tatiana A. Chernova Yury O. Chernoff Keith D. Wilkinson Tags: Review Source Type: research

Molecules, Vol. 24, Pages 3389: New Functional Ingredients Based on Microencapsulation of Aqueous Anthocyanin-Rich Extracts Derived from Black Rice (Oryza sativa L.)
Nicoleta Stănciuc The aqueous anthocyanin-rich extract derived from black rice (Oryza sativa L.) was encapsulated by freeze drying using milk proteins and peptides as coating materials. The molecular modelling approach indicated that all major casein fractions and whey proteins were able to bind at least one anthocyanin molecule. The hydrophobic interactions and hydrogen bonding across the interfaces appeared to be mainly responsible for the stabilizations of the complexes formed between the coating material and bioactive compounds. Two dark purple colored powders, differentiated by the ratio of the encapsulation ma...
Source: Molecules - September 18, 2019 Category: Chemistry Authors: Iuliana Aprodu Ștefania Adelina Milea Roxana-M ădălina Anghel Elena Enachi Vasilica Barbu Oana Cr ăciunescu Gabriela R âpeanu Gabriela Elena Bahrim Anca Oancea Nicoleta St ănciuc Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3390: Trilobatin, a Novel SGLT1/2 Inhibitor, Selectively Induces the Proliferation of Human Hepatoblastoma Cells
In this study, the molecular docking showed that, trilobatin, one of the dihydrochalcones from leaves of Lithocarpus polystachyus Rehd., might be a novel inhibitor of SGLT1 and SGLT2, which evidently attenuated the uptake of glucose in vitro and in vivo. To our surprise, we observed that trilobatin did not inhibit, but promoted the proliferation of human hepatoblastoma HepG2 and Huh 7 cells when it was present at high concentrations. At the same time, incubation with high concentrations of trilobatin arrested the cell cycle at S phase in HepG2 cells. We also found that treatment with trilobatin had no significant effect on...
Source: Molecules - September 18, 2019 Category: Chemistry Authors: Lujing Wang Min Liu Fei Yin Yuanqiang Wang Xingan Li Yucui Wu Cuilian Ye Jianhui Liu Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3391: Isothioureas, Ureas, and Their N-Methyl Amides from 2-Aminobenzothiazole and Chiral Amino Acids
Alejandro Cruz Ángel Andrés Ramos-Organillo In this investigation, the reaction of 2-dithiomethylcarboimidatebenzothiazole with a series of six chiral amino-acids was studied. The reaction proceeds through the isolable sodium salt of SMe-isothiourea carboxylates as intermediates, whose reaction with methyl iodide in stirring DMF as solvent affords SMe-isothiourea methyl esters. The presence of water in the reaction leads to the corresponding urea carboxylates as isolable intermediates, whose methyl esters were obtained. Finally, the urea N-methyl amide derivatives were isolated when SMe-isothiourea or ...
Source: Molecules - September 18, 2019 Category: Chemistry Authors: Itzia I. Padilla-Mart ínez Jos é Miguel González-Encarnación Efr én V. García-Báez Alejandro Cruz Ángel Andrés Ramos-Organillo Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3392: Effect of Ethanol on the Adsorption of Volatile Sulfur Compounds on Solid Phase Micro-Extraction Fiber Coatings and the Implication for Analysis in Wine
ian Complications in the analysis of volatile sulfur compounds (VSC) in wine using solid-phase microextraction (SPME) arise from sample variability. Constituents of the wine matrix, including ethanol, affect the volatility and adsorption of sulfur volatiles on SPME fiber coatings (Carboxen- polydimethylsiloxane(PDMS); DVB-Carboxen-PDMS and DVB-PDMS), which can impact sensitivity and accuracy. Here, several common wine sulfur volatiles, including hydrogen sulfide (H2S), methanethiol (MeSH), dimethyl sulfide (DMS), dimethyl disulfide (DMDS), dimethyl trisulfide (DMTS), diethyl disulfide (DEDS), methyl thioacetate (MeSOAc...
Source: Molecules - September 18, 2019 Category: Chemistry Authors: Peter M. Davis Michael C. Qian Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3393: Proanthocyanidin-Rich Fractions from Red Rice Extract Enhance TNF- α-Induced Cell Death and Suppress Invasion of Human Lung Adenocarcinoma Cell A549
This study investigated the molecular mechanisms associated with PRFR on cell survival and metastasis of TNF-α-induced A549 human lung adenocarcinoma. Notably, PRFR enhanced TNF-α-induced A549 cell death when compared with PRFP alone and caused a G0-G1 cell cycle arrest. Although, PRFR alone enhanced cell apoptosis, the combination treatment induced the cells that had been enhanced with PRFR and TNF-α to apoptosis that was less than PRFR alone and displayed a partial effect on caspase-8 activation and PARP cleavage. By using the autophagy inhibitor; 3-MA attenuated the effect of ho...
Source: Molecules - September 18, 2019 Category: Chemistry Authors: Chayaporn Subkamkaew Pornngarm Limtrakul (Dejkriengkraikul) Supachai Yodkeeree Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3394: (10Z)-Debromohymenialdisine from Marine Sponge Stylissa sp. Regulates Intestinal Inflammatory Responses in Co-Culture Model of Epithelial Caco-2 Cells and THP-1 Macrophage Cells
Eun Ju Jeong Crohn’s disease (CD) and ulcerative colitis (UC), collectively referred to as inflammatory bowel disease (IBD), are autoimmune diseases characterized by chronic inflammation within the gastrointestinal tract. Debromohymenialdisine is an active pyrrole alkaloid that is well known to serve as a stable and effective inhibitor of Chk2. In the present study, we attempted to investigate the anti-inflammatory properties of (10Z)-debromohymenialdisine (1) isolated from marine sponge Stylissa species using an intestinal in vitro model with a transwell co-culture system. The treatment with 1 attenuate...
Source: Molecules - September 18, 2019 Category: Chemistry Authors: Seon Min Lee Na-Hyun Kim Sangbum Lee Yun Na Kim Jeong-Doo Heo Jung-Rae Rho Eun Ju Jeong Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3395: Formation and Stabilization of Gold Nanoparticles in Bovine Serum Albumin Solution
This study shows that albumins act as both reducing agents and protective corona of AuNPs. (Source: Molecules)
Source: Molecules - September 18, 2019 Category: Chemistry Authors: Iulia Matei Cristina Maria Buta Ioana Maria Turcu Daniela Culita Cornel Munteanu Gabriela Ionita Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3396: Effects of the Ethanol Extract of Dipterocarpus alatus Leaf on the Unpredictable Chronic Mild Stress-Induced Depression in ICR Mice and Its Possible Mechanism of Action
hulikhit Kijjoa Treatment of the unpredictable chronic mild stress (UCMS) mice with the ethanol extract of Dipterocarpus alatus leaf attenuated anhedonia (increased sucrose preference) and behavioral despair (decreased immobility time in tail suspension test (TST) and forced swimming test (FST)). The extract not only decreased the elevation of serum corticosterone level and the index of over-activation of the hypothalamic-pituitary-adrenal (HPA) axis, caused by UCMS, but also ameliorated UCMS-induced up-regulation of serum- and glucocorticoid-inducible kinase 1 (SGK1) mRNA expression and down-regulation of cyclic AM...
Source: Molecules - September 18, 2019 Category: Chemistry Authors: Daodee Monthakantirat Ruengwinitwong Gatenakorn Maneenet Khamphukdee Sekeroglu Chulikhit Kijjoa Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3378: Effect of PLA/PBAT Antibacterial Film on Storage Quality of Passion Fruit during the Shelf-Life
Yaowen Liu In this experiment, we studied the effect of poly(lactic acid)/poly(butylene adipate-co-terephthalate) (PLA/PBAT) blend films on the efficiency of passion fruit preservation at 20 °C. The weight loss, shrinkage index, firmness, and total sugar of passion fruit packaged with PLA/PBAT films had no significant differences compared with PE films during 21 days (p > 0.05). PLA/PBAT films can more effectively reduce the rising of ethanol content and delay the total acid, ascorbic acid, and sensory evaluation. Compared with unpackaged (CK) and polyethylene (PE) films, PLA/PBAT films are mo...
Source: Molecules - September 17, 2019 Category: Chemistry Authors: Rong Zhang Wenting Lan Jie Ding Saeed Ahmed Wen Qin Li He Yaowen Liu Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3377: Sensory Metabolite Profiling in a Date Pit Based Coffee Substitute and in Response to Roasting as Analyzed via Mass Spectrometry Based Metabolomics
This study provides the first insight into the roasting impact on the date pit through its metabolome and its neuropharmacological aspects to rationalize its use as a coffee substitute. (Source: Molecules)
Source: Molecules - September 17, 2019 Category: Chemistry Authors: Mohamed A. Farag Asmaa M. Otify Aly M. El-Sayed Camilia G. Michel Shaimaa A. ElShebiney Anja Ehrlich Ludger A. Wessjohann Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3379: Mir-152 Regulates 3T3-L1 Preadipocyte Proliferation and Differentiation
Zhang Lin Bai Li Zhu Adipogenesis is a complex biological process and the main cause of obesity. Recently, microRNAs (miRNAs), a class of small endogenous non-coding RNAs, have been proven to play an important role in adipogenesis by the post-transcriptional regulation of target genes. In this current study, we observed an increment of miR-152 expression during the process of 3T3-L1 cell audiogenic differentiation. A functional analysis indicated that the overexpression of miR-152 inhibited pre-adipocyte proliferation and suppressed the expression of some cell cycle-related genes. Moreover, the overexpression of m...
Source: Molecules - September 17, 2019 Category: Chemistry Authors: Yuan Fan Mailin Gan Ya Tan Lei Chen Linyuan Shen Lili Niu Yihui Liu Guoqing Tang Yanzhi Jiang Xuewei Li Shunhua Zhang Lin Bai Li Zhu Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3380: Transcriptome and Metabolite Profiling Reveal Novel Insights into Volatile Heterosis in the Tea Plant (Camellia Sinensis)
Naixing Ye Tea aroma is a key indicator for evaluating tea quality. Although notable success in tea aroma improvement has been achieved with heterosis breeding technology, the molecular basis underlying heterosis remains largely unexplored. Thus, the present report studies the tea plant volatile heterosis using a high-throughput next-generation RNA-seq strategy and gas chromatography–mass spectrometry. Phenotypically, we found higher terpenoid volatile and green leaf volatile contents by gas chromatography–mass spectrometry in the F1 hybrids than in their parental lines. Volatile heterosis ...
Source: Molecules - September 17, 2019 Category: Chemistry Authors: Yucheng Zheng Pengjie Wang Xuejin Chen Yun Sun Chuan Yue Naixing Ye Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3381: The Comprehensive Evaluation of Safflowers in Different Producing Areas by Combined Analysis of Color, Chemical Compounds, and Biological Activity
Yu-Ping Tang Jin-Ao Duan In the present study, a new strategy including the combination of external appearance, chemical detection, and biological analysis was proposed for the comprehensive evaluation of safflowers in different producing areas. Firstly, 40 batches of safflower samples were classified into class I and II based on color measurements and K-means clustering analysis. Secondly, a rapid and sensitive analytical method was developed for simultaneous quantification of 16 chromaticity-related characteristic components (including characteristic components hydroxysafflor yellow A, anhydrosafflor yellow B, saf...
Source: Molecules - September 17, 2019 Category: Chemistry Authors: Zong-Jin Pu Shi-Jun Yue Gui-Sheng Zhou Hui Yan Xu-Qin Shi Zhen-Hua Zhu Sheng-Liang Huang Guo-Ping Peng Yan-Yan Chen Ji-Qing Bai Xiao-Ping Wang Shu-Lan Su Yu-Ping Tang Jin-Ao Duan Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3382: Electrical and Electrochemical Behavior of Carbon Paste Electrodes Modified with Ionic Liquids Based in N-Octylpyridinium Bis(Trifluoromethylsulfonyl)Imide. A Theoretical and Experimental Study
cute;a Ramírez Palenzuela In this work, we studied carbon paste electrodes (CPEs) with two kinds of binders: mineral oil or ionic liquids (IL) derived from N-substituted octyl pyridinium bis(trifluoromethylsulfonyl)imide with the substituents H-, CH3-, CN- and CF3-. The work aims to study this series of IL and determine a possible effect of the substituent of the cation in the behavior of the IL as a binder of graphite for obtaining IL-CPEs. The electrochemical response and the electrical behavior were measured by cyclic voltammetry and electrochemical impedance spectroscopy, respectively. Surprisingly, th...
Source: Molecules - September 17, 2019 Category: Chemistry Authors: B áez Navarro Fuenzalida Aguirre Ar évalo Afonso Garc ía Ram írez Palenzuela Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3383: Toxicity Prediction Method Based on Multi-Channel Convolutional Neural Network
Zhang Li Molecular toxicity prediction is one of the key studies in drug design. In this paper, a deep learning network based on a two-dimension grid of molecules is proposed to predict toxicity. At first, the van der Waals force and hydrogen bond were calculated according to different descriptors of molecules, and multi-channel grids were generated, which could discover more detail and helpful molecular information for toxicity prediction. The generated grids were fed into a convolutional neural network to obtain the result. A Tox21 dataset was used for the evaluation. This dataset contains more than 12,000 mole...
Source: Molecules - September 17, 2019 Category: Chemistry Authors: Yuan Wei Guan Jiang Wang Zhang Li Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3384: Accramycin A, a New Aromatic Polyketide, from the Soil Bacterium, Streptomyces sp. MA37
eremeh Deng Drug-like molecules are known to contain many different building blocks with great potential as pharmacophores for drug discovery. The continued search for unique scaffolds in our laboratory led to the isolation of a novel Ghanaian soil bacterium, Streptomyces sp. MA37. This strain produces many bioactive molecules, most of which belong to carbazoles, pyrrolizidines, and fluorinated metabolites. Further probing of the metabolites of MA37 has led to the discovery of a new naphthacene-type aromatic natural product, which we have named accramycin A 1. This molecule was isolated using an HPLC-photodiode arra...
Source: Molecules - September 17, 2019 Category: Chemistry Authors: Maglangit Fang Leman Soldatou Ebel Kyeremeh Deng Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3375: Screening 89 Pesticides in Fishery Drugs by Ultrahigh Performance Liquid Chromatography Tandem Quadrupole-Orbitrap Mass Spectrometer
Juan Yu Multiclass screening of drugs with high resolution mass spectrometry is of great interest due to its high time-efficiency and excellent accuracy. A high-scale, fast screening method for pesticides in fishery drugs was established based on ultrahigh performance liquid chromatography tandem quadrupole-Orbitrap high-resolution mass spectrometer. The target compounds - were diluted in methanol and extracted by ultrasonic treatment, and the extracts were diluted with MeOH-water (1:1, v/v) and centrifuged to remove impurities. The chromatographic separation was performed on an Accucore aQ-MS column (100 mm &t...
Source: Molecules - September 17, 2019 Category: Chemistry Authors: Shou-Ying Wang Cong Kong Qing-Ping Chen Hui-Juan Yu Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3376: Anti-Inflammatory Properties of Bellevalia saviczii Root Extract and Its Isolated Homoisoflavonoid (Dracol) Are Mediated by Modification on Calcium Signaling
Gloria Brusotti Bellevalia saviczii is a medicinal plant used as anti-rheumatic and anti-inflammatory herbal remedy in Iraqi-Kurdistan. The aim of this study was to evaluate the anti-inflammatory activity of its extract and the isolated homoisoflavonoid (Dracol) by studying the Ca2+-dependent NF-kB pathway. Nuclear translocation of p65 NF-kB subunit, as parameter of NF-kB activation, was visualized in human leukemic monocytes by immunofluorescence and Western blot analyses, after cell treatment with B. saviczii root extract or Dracol followed by Lipopolysaccharide stimulation. In parallel, Ca2+ signals responsible fo...
Source: Molecules - September 17, 2019 Category: Chemistry Authors: Monica Savio Mohammed Farhad Ibrahim Chiara Scarlata Matteo Orgiu Giuseppe Accardo Abdullah Shakur Sardar Francesco Moccia Lucia Anna Stivala Gloria Brusotti Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3374: Fabrication of Graphene/Molybdenum Disulfide Composites and Their Usage as Actuators for Electrochemical Sensors and Biosensors
Zitka From the rediscovery of graphene in 2004, the interest in layered graphene analogs has been exponentially growing through various fields of science. Due to their unique properties, novel two-dimensional family of materials and especially transition metal dichalcogenides are promising for development of advanced materials of unprecedented functions. Progress in 2D materials synthesis paved the way for the studies on their hybridization with other materials to create functional composites, whose electronic, physical or chemical properties can be engineered for special applications. In this review we focused on rece...
Source: Molecules - September 17, 2019 Category: Chemistry Authors: Jiri Kudr Vojtech Adam Ondrej Zitka Tags: Review Source Type: research

Molecules, Vol. 24, Pages 3359: Improved Antioxidant, Anti-inflammatory, and Anti-adipogenic Properties of Hydroponic Ginseng Fermented by Leuconostoc mesenteroides KCCM 12010P
Paik Hydroponic ginseng (HPG) has been known to have various bio-functionalities, including an antioxidant effect. Recently, fermentation by lactic acid bacteria has been studied to enhance bio-functional activities in plants by biologically converting their chemical compounds. HPG roots and shoots were fermented with Leuconostoc mesenteroides KCCM 12010P isolated from kimchi. The total phenolic compounds, antioxidant, anti-inflammatory, and anti-adipogenic effects of these fermented samples were evaluated in comparison with non-fermented samples (control). During 24 h fermentation of HPG roots and shoots, the viable ...
Source: Molecules - September 16, 2019 Category: Chemistry Authors: Ji Eun Hwang Kee-Tae Kim Hyun-Dong Paik Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3360: Comparison of the Interactions of Different Growth Factors and Glycosaminoglycans
t J. Linhardt Most growth factors are naturally occurring proteins, which are signaling molecules implicated in cellular multiple functions such as proliferation, migration and differentiation under patho/physiological conditions by interacting with cell surface receptors and other ligands in the extracellular microenvironment. Many of the growth factors are heparin-binding proteins (HBPs) that have a high affinity for cell surface heparan sulfate proteoglycans (HSPG). In the present study, we report the binding kinetics and affinity of heparin interacting with different growth factors, including fibroblast growth fact...
Source: Molecules - September 16, 2019 Category: Chemistry Authors: Fuming Zhang Langhong Zheng Shuihong Cheng Yanfei Peng Li Fu Xing Zhang Robert J. Linhardt Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3361: A Novel One-Dimensional Porphyrin-Based Covalent Organic Framework
Xuan Sun A novel one-dimensional covalent organic framework (COF-K) was firstly designed and synthesized through a Schiff-based reaction from a porphyrin building block and a nonlinear right-angle building block. The COF-K exhibited high BET surface area and narrow pore size of 1.25 nm and gave a CO2 adsorption capacity of 89 mg g−1 at 273K and 1bar. (Source: Molecules)
Source: Molecules - September 16, 2019 Category: Chemistry Authors: Miao Zhang Ruijin Zheng Ying Ma Ruiping Chen Xun Sun Xuan Sun Tags: Communication Source Type: research

Molecules, Vol. 24, Pages 3362: A High Throughput Apoptosis Assay using 3D Cultured Cells
o Lee A high throughput apoptosis assay using 3D cultured cells was developed with a micropillar/microwell chip platform. Live cell apoptosis assays based on fluorescence detection have been useful in high content screening. To check the autofluorescence of drugs, controls (no caspase-3/7 reagent in the assay) for the drugs are necessary which require twice the test space. Thus, a high throughput capability and highly miniaturized format for reducing reagent usage are necessary in live cell apoptosis assays. Especially, the expensive caspase-3/7 reagent should be reduced in a high throughput screening system. To solve ...
Source: Molecules - September 16, 2019 Category: Chemistry Authors: Sang-Yun Lee Il Doh Dong Woo Lee Tags: Technical Note Source Type: research

Molecules, Vol. 24, Pages 3363: Neutral Lipid Content in Lipid Droplets: Potential Biomarker of Cordycepin Accumulation in Cordycepin-Producing Fungi
In conclusion, neutral lipids in lipid droplets are required during cordycepin accumulation; these neutral lipids are potential biomarkers of cordycepin biosynthesis. (Source: Molecules)
Source: Molecules - September 16, 2019 Category: Chemistry Authors: Peng Qin ZhiYe Wang DengXue Lu HongMei Kang Guang Li Rui Guo YuHui Zhao RongBing Han Bing Ji Yang Zeng Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3364: Structural Characterization and Antioxidant Activity of Polysaccharides from Athyrium multidentatum (Doll.) Ching in d-Galactose-Induced Aging Mice via PI3K/AKT Pathway
Conclusion: AMC polysaccharides attenuated d-galactose-induced oxidative stress and cell apoptosis by activating the PI3K/AKT pathway, which might in part contributed to their anti-aging activity. (Source: Molecules)
Source: Molecules - September 16, 2019 Category: Chemistry Authors: Liang Jing Jing-Ru Jiang Dong-Mei Liu Ji-Wen Sheng Wei-Fen Zhang Zhi-Jian Li Liu-Ya Wei Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3365: Development and Validation of a Virtual Gelatin Model Using Molecular Modeling Computational Tools
chowski To successfully design and optimize the application of hydrogel matrices one has to effectively combine computational design tools with experimental methods. In this context, one of the most promising techniques is molecular modeling, which requires however accurate molecular models representing the investigated material. Although this method has been successfully used over the years for predicting the properties of polymers, its application to biopolymers, including gelatin, is limited. In this paper we provide a method for creating an atomistic representation of gelatin based on the modified FASTA codes of na...
Source: Molecules - September 16, 2019 Category: Chemistry Authors: Lukasz Radosinski Karolina Labus Piotr Zemojtel Jakub W. Wojciechowski Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3366: Effect of Nanocrystallization of Anthocyanins Extracted from Two Types of Red-Fleshed Apple Varieties on Its Stability and Antioxidant Activity
In this study we extracted total anthocyanins and phenols from two types of red-fleshed apples—Xinjing No.4 (XJ4) and Red Laiyang (RL)—to study the stability and antioxidant activity of anthocyanins after encapsulation onto Corn Starch Nanoparticles (CSNPs). The results indicated the anthocyanins and total phenol levels of XJ4 were 2.96 and 2.25 times higher than those of RL respectively. The anthocyanin concentration and loading time had a significant effect on CSNPs encapsulation, and XJ4 anthocyanins always showed significantly higher loading capacity than RL. After encapsulation, the morphol...
Source: Molecules - September 16, 2019 Category: Chemistry Authors: Jihua Xu Xinxin Li Shifeng Liu Peilei Zhao Heqiang Huo Yugang Zhang Tags: Article Source Type: research