Molecules, Vol. 28, Pages 1469: Synthesis: Molecular Structure, Thermal-Calorimetric and Computational Analyses, of Three New Amine Borane Adducts
t B. Demirci Cyclopropylamine borane C3H5NH2BH3 (C3AB), 2-ethyl-1-hexylamine borane CH3(CH2)3CH(C2H5)CH2NH2BH3 (C2C6AB) and didodecylamine borane (C12H25)2NHBH3 ((C12)2AB) are three new amine borane adducts (ABAs). They are synthesized by reaction of the corresponding amines with a borane complex, the reaction being exothermic as shown by Calvet calorimetry. The successful synthesis of each has been demonstrated by FTIR, Raman and NMR. For instance, the 11B NMR spectra show the presence of signals typical of the NBH3 environment, thereby implying the formation of B–N bonds. The occurrence of dihydrogen bo...
Source: Molecules - February 3, 2023 Category: Chemistry Authors: Kevin Turani-I-Belloto Rodica Chiriac Fran çois Toche Eddy Petit Pascal G. Yot Johan G. Alauzun Umit B. Demirci Tags: Article Source Type: research

Molecules, Vol. 28, Pages 1470: Pillararene-Based Supramolecular Polymers for Cancer Therapy
hou Supramolecular polymers have attracted considerable interest due to their intriguing features and functions. The dynamic reversibility of noncovalent interactions endows supramolecular polymers with tunable physicochemical properties, self-healing, and externally stimulated responses. Among them, pillararene-based supramolecular polymers show great potential for biomedical applications due to their fascinating host–guest interactions and easy modification. Herein, we summarize the state of the art of pillararene-based supramolecular polymers for cancer therapy and illustrate its developmental trend an...
Source: Molecules - February 3, 2023 Category: Chemistry Authors: Miaomiao Yan Jiong Zhou Tags: Review Source Type: research

Molecules, Vol. 28, Pages 1471: Decoration of Polyfluorene-Wrapped Carbon Nanotubes with Photocleavable Side-Chains
nov Functionalizing polyfluorene-wrapped carbon nanotubes without damaging their properties is effective via Copper-Catalyzed Azide–Alkyne Cycloaddition (CuAAC). However, the length and nature of polymer side-chains can impact the conductivity of polyfluorene-SWNT films by preventing close contact between the nanotubes. Here, we investigate the functionalization of a polyfluorene-SWNT complex using photocleavable side-chains that can be removed post-processing. The cleavage of the side-chains containing an ortho-nitrobenzyl ether derivative is efficient when exposed to a UV lamp at 365 nm. The photoisomer...
Source: Molecules - February 3, 2023 Category: Chemistry Authors: Dialia Ritaine Alex Adronov Tags: Article Source Type: research

Molecules, Vol. 28, Pages 1474: Biotechnology Advances in Bioremediation of Arsenic: A Review
el Ondrasek Arsenic is a highly toxic metalloid widespread in the Earth's crust, and its contamination due to different anthropogenic activities (application of agrochemicals, mining, waste management) represents an emerging environmental issue. Therefore, different sustainable and effective remediation methods and approaches are needed to prevent and protect humans and other organisms from detrimental arsenic exposure. Among numerous arsenic remediation methods, those supported by using microbes as sorbents (microbial remediation), and/or plants as green factories (phytoremediation) are considered as cost-effecti...
Source: Molecules - February 3, 2023 Category: Chemistry Authors: Jaganathan Sakthi Yazhini Preetha Muthukrishnan Arun Nandakumar Vidya Kumaresan Kowsalya Jayachandran Halka Gabrijel Ondrasek Tags: Review Source Type: research

Molecules, Vol. 28, Pages 1475: Recent Advances of Modified Ni (Co, Fe)-Based LDH 2D Materials for Water Splitting
Tao Sun Water splitting technology is an efficient approach to produce hydrogen (H2) as an energy carrier, which can address the problems of environmental deterioration and energy shortage well, as well as establishment of a clean and sustainable hydrogen economy powered by renewable energy sources due to the green reaction of H2 with O2. The efficiency of H2 production by water splitting technology is intimately related with the reactions on the electrode. Nowadays, the efficient electrocatalysts in water splitting reactions are the precious metal-based materials, i.e., Pt/C, RuO2, and IrO2. Ni (Co, Fe)-based layere...
Source: Molecules - February 3, 2023 Category: Chemistry Authors: Chenguang Li Yupeng Bao Enzhou Liu Binran Zhao Tao Sun Tags: Review Source Type: research

Molecules, Vol. 28, Pages 1476: Effect of Isoquercitrin on Free Fatty Acid-Induced Lipid Accumulation in HepG2 Cells
ng-Suk Jung Liver metabolic disorders and oxidative stress are crucial factors in the development of nonalcoholic fatty liver disease (NAFLD); however, treatment strategies to combat NAFLD remain poorly established, presenting an important challenge that needs to be addressed. Herein, we aimed to examine the effect of isoquercitrin on lipid accumulation induced by exogenous free fatty acids (FFA) using HepG2 cells and elucidate the underlying molecular mechanism. The cells were exposed to 0.5 mM FFA to induce intracellular lipid accumulation, followed by co-treatment with isoquercitrin to confirm the potential inhibito...
Source: Molecules - February 3, 2023 Category: Chemistry Authors: Sou Hyun Kim Chawon Yun Doyoung Kwon Yun-Hee Lee Jae-Hwan Kwak Young-Suk Jung Tags: Article Source Type: research

Molecules, Vol. 28, Pages 1473: Chitosan-Based Hemostatic Hydrogels: The Concept, Mechanism, Application, and Prospects
ige Wang The design of new hemostatic materials to mitigate uncontrolled bleeding in emergencies is challenging. Chitosan-based hemostatic hydrogels have frequently been used for hemostasis due to their unique biocompatibility, tunable mechanical properties, injectability, and ease of handling. Moreover, chitosan (CS) absorbs red blood cells and activates platelets to promote hemostasis. Benefiting from these desired properties, the hemostatic application of CS hydrogels is attracting ever-increasing research attention. This paper reviews the recent research progress of CS-based hemostatic hydrogels and their advantage...
Source: Molecules - February 3, 2023 Category: Chemistry Authors: Peng Fan Yanbo Zeng Dionisio Zaldivar-Silva Lissette Ag üero Shige Wang Tags: Review Source Type: research

Molecules, Vol. 28, Pages 1477: Interaction between [( & eta;6-p-cym)M(H2O)3]2+ (MII = Ru, Os) or [( & eta;5-Cp*)M(H2O)3]2+ (MIII = Rh, Ir) and Phosphonate Derivatives of Iminodiacetic Acid: A Solution Equilibrium and DFT Study
Molecules, Vol. 28, Pages 1477: Interaction between [(η6-p-cym)M(H2O)3]2+ (MII = Ru, Os) or [(η5-Cp*)M(H2O)3]2+ (MIII = Rh, Ir) and Phosphonate Derivatives of Iminodiacetic Acid: A Solution Equilibrium and DFT Study Molecules doi: 10.3390/molecules28031477 Authors: Linda Bíró Botond Tóth Norbert Lihi Etelka Farkas Péter Buglyó The pH-dependent binding strengths and modes of the organometallic [(η6-p-cym)M(H2O)3]2+ (MII = Ru, Os; p-cym = 1-methyl-4-isopropylbenzene) or [(η5-Cp*)M(H2O)3]2+ (MIII = Rh, Ir; Cp* = pentamethylcyclopentadienyl anion) cations towards imi...
Source: Molecules - February 3, 2023 Category: Chemistry Authors: Linda B író Botond T óth Norbert Lihi Etelka Farkas P éter Buglyó Tags: Article Source Type: research

Molecules, Vol. 28, Pages 1472: Thermal Annealing Effect on Surface-Enhanced Raman Scattering of Gold Films Deposited on Liquid Substrates
Fan Gao Bo Yan We prepare metal films with various thicknesses on liquid substrates by thermal evaporation and investigate the annealing effect on these films. Gold films deposited on a silicone oil surface consist of a large number of branched aggregates, which contains plenty of gold nanoparticles. This characteristic morphology is mainly attributed to the isotropic and free-sustained liquid substrate. Thermal annealing results in the reintegration of nanoparticles; thus, the surface morphology and microstructure of gold films change significantly. The dependence of annealing conditions on the surface-enhanced Ram...
Source: Molecules - February 3, 2023 Category: Chemistry Authors: Ziran Ye Haixia Huang Fengyun Xu Ping Lu Yiben Chen Jiawei Shen Gaoxiang Ye Fan Gao Bo Yan Tags: Article Source Type: research

Molecules, Vol. 28, Pages 1478: Methyl Jasmonate and Nanoparticles Doped with Methyl Jasmonate affect the Cell Wall Composition of Monastrell Grape Skins
Rocío Gil-Muñoz The structural composition of the cell wall of grape skins is related to the cell wall integrity and subsequent extraction of the different compounds that are contained inside vacuoles and also the cell wall breakdown products. Different reports have established that methyl jasmonate (MeJ) produces changes in the composition of the grape skin cell wall. The use of elicitors to promote the production of secondary metabolites in grapes has been studied in several reports; however, its study linked to nanotechnology is less developed. These facts led us to study the effect of methyl jasmonate (MeJ) and...
Source: Molecules - February 3, 2023 Category: Chemistry Authors: Mar ía José Giménez-Bañón Diego Fernando Paladines-Quezada Juan Daniel Moreno-Olivares Juan Antonio Bleda-S ánchez Jos é Ignacio Fernández-Fernández Bel én Parra-Torrejón Gloria Bel én Ramírez-Rodríguez Jos é Manuel Delgado-López Roc ío G Tags: Article Source Type: research

Molecules, Vol. 28, Pages 1480: Amyloid-like RIP1/RIP3 RHIM Fragments & rsquo; Characterization and Application as a Drug Depot
Molecules, Vol. 28, Pages 1480: Amyloid-like RIP1/RIP3 RHIM Fragments’ Characterization and Application as a Drug Depot Molecules doi: 10.3390/molecules28031480 Authors: Maytham Ismail Mathumai Kanapathipillai Amyloid aggregates play a major role in diseases as well as in normal physiological function. Receptor-interacting protein kinases 1 and 3 (RIP1/RIP3) aggregates complexes in cellular necroptosis is one example of protein aggregation in normal cellular function. Although recently there have been several studies on full kinase proteins aggregation, the aggregation potential of small peptide sequenc...
Source: Molecules - February 3, 2023 Category: Chemistry Authors: Maytham Ismail Mathumai Kanapathipillai Tags: Article Source Type: research

Molecules, Vol. 28, Pages 1479: Biotransformation of Penindolone, an Influenza A Virus Inhibitor
ang Zhihua Lv Penindolone (PND) is a novel broad-spectrum anti-Influenza A Virus (IAV) agent blocking hemagglutinin-mediated adsorption and membrane fusion. The goal of this work was to reveal the metabolic route of PND in rats. Ultra-high-performance liquid chromatography tandem high-resolution mass spectrometry (UHPLC–HRMS) was used for metabolite identification in rat bile, feces and urine after administration of PND. A total of 25 metabolites, including 9 phase I metabolites and 16 phase II metabolites, were characterized. The metabolic pathways were proposed, and metabolites were visualized via Glo...
Source: Molecules - February 3, 2023 Category: Chemistry Authors: Shuai Liu Keming Zheng Yilin Jiang Susu Gai Bohan Li Dehai Li Shuang Yang Zhihua Lv Tags: Article Source Type: research

Molecules, Vol. 28, Pages 1481: Novel Indole-Containing Hybrids Derived from Millepachine: Synthesis, Biological Evaluation and Antitumor Mechanism Study
In this study, novel indole-containing hybrids derived from millepachine were designed, synthesized and evaluated for their antitumor activities. Among all the compounds, compound 14b exhibited the most potent cytotoxic activity against five kinds of human cancer cell lines, with IC50 values ranging from 0.022 to 0.074 μM, making it almost 100 times more active than millepachine. Valuable structure–activity relationships (SARs) were obtained. Furthermore, the mechanism studies showed that compound 14b induced cell-cycle arrest at the G2/M phase by inhibiting tubulin polymerization and further induc...
Source: Molecules - February 3, 2023 Category: Chemistry Authors: Baoxia Liang Qing Zou Lintao Yu Yali Wang Jun Yan Baiqi Huang Tags: Article Source Type: research

Molecules, Vol. 28, Pages 1482: Radiolabelling of Polyclonally Expanded Human Regulatory T Cells (Treg) with 89Zr-oxine for Medium-Term In Vivo Cell Tracking
O. Fruhwirth Regulatory T cells (Tregs) are a promising candidate cell therapy to treat autoimmune diseases and aid the longevity of transplanted solid organs. Despite increasing numbers of clinical trials using human Treg therapy, important questions pertaining to their in vivo fate, distribution, and function remain unanswered. Treg accumulation in relevant tissues was found to be crucial for Treg therapy efficacy, but existing blood-borne biomarkers are unlikely to accurately reflect the tissue state. Non-invasive Treg tracking by whole-body imaging is a promising alternative and can be achieved by direct radiolabe...
Source: Molecules - February 3, 2023 Category: Chemistry Authors: Jacinta Jacob Alessia Volpe Qi Peng Robert I. Lechler Lesley A. Smyth Giovanna Lombardi Gilbert O. Fruhwirth Tags: Article Source Type: research

Molecules, Vol. 28, Pages 1483: Characterization and Comparison of Extra Virgin Olive Oils of Turkish Olive Cultivars
z Extra virgin olive oils (EVOOs) obtained from five Turkish olive cultivars widely produced in the Aegean and Marmara regions were investigated based on their total antioxidant capacity (TAC), total phenolic content (TPC), pigment contents, fatty acid (FA) profiles, phenolic compounds (PC), volatile compounds (VC), and sensory properties. The results showed that all properties of EVOO samples were significantly affected by the olive cultivar used. The pigment contents in Ayvalık (9.90 mg·kg−1) and Uslu (9.00 mg·kg−1) oils were higher than the other...
Source: Molecules - February 3, 2023 Category: Chemistry Authors: Aziz Korkmaz Tags: Article Source Type: research