Molecules, Vol. 29, Pages 1992: A Rare Mono-Rhamnolipid Congener Efficiently Produced by Recombinant Pseudomonas aeruginosa YM4 via the Expression of Global Transcriptional Regulator irrE
Shuang Li
Rhamnolipids (RLs) are widely used biosurfactants produced mainly by Pseudomonas aeruginosa and Burkholderia spp. in the form of mixtures of diverse congeners. The global transcriptional regulator gene irrE from radiation-tolerant extremophiles has been widely used as a stress-resistant element to construct robust producer strains and improve their production performance. A PrhlA-irrE cassette was constructed to express irrE genes in the Pseudomonas aeruginosa YM4 of the rhamnolipids producer strain. We found that the expression of irrE of Deinococcus radiodurans in the YM4 strain not only enhanced rhamnolipi...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Xinying Wang Dongmei Li Shenghui Yue Zhangzhong Yuan Shuang Li Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1994: Green Synthesis of Blumea balsamifera Oil Nanoemulsions Stabilized by Natural Emulsifiers and Its Effect on Wound Healing
In this study, we developed a green and multifunctional bioactive nanoemulsion (BBG-NEs) of Blumea balsamifera oil using Bletilla striata polysaccharide (BSP) and glycyrrhizic acid (GA) as natural emulsifiers. The process parameters were optimized using particle size, PDI, and zeta potential as evaluation parameters. The physicochemical properties, stability, transdermal properties, and bioactivities of the BBG-NEs under optimal operating conditions were investigated. Finally, network pharmacology and molecular docking were used to elucidate the potential molecular mechanism underlying its wound-healing properties. After p...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Lingfeng Du Chunfang Ma Bingnan Liu Wei Liu Yue Zhu Zuhua Wang Teng Chen Luqi Huang Yuxin Pang Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1993: A Red-Emission Fluorescent Probe with Large Stokes Shift for Detection of Viscosity in Living Cells and Tumor-Bearing Mice
ong Huang
Abnormal viscosity is closely related to the occurrence of many diseases, such as cancer. Therefore, real-time detection of changes in viscosity in living cells is of great importance. Fluorescent molecular rotors play a critical role in detecting changes in cellular viscosity. Developing red emission viscosity probes with large Stokes shifts and high sensitivity and specificity remains an urgent and important topic. Herein, a novel viscosity-sensitive fluorescent probe (TCF-VIS1) with a large stokes shift and red emission was prepared based on the 2-dicyanomethylene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran (...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Beilei Wang Dezhi Yang Xiaohong Zhong Yuhui Liu Yong Huang Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1995: Carbonic Anhydrases: Different Active Sites, Same Metal Selectivity Rules
Dudev
Carbonic anhydrases are mononuclear metalloenzymes catalyzing the reversible hydration of carbon dioxide in organisms belonging to all three domains of life. Although the mechanism of the catalytic reaction is similar, different families of carbonic anhydrases do not have a common ancestor nor do they exhibit significant resemblance in the amino acid sequence or the structure and composition of the metal-binding sites. Little is known about the physical principles determining the metal affinity and selectivity of the catalytic centers, and how well the native metal is protected from being dislodged by other metal...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Nikoleta Kircheva Silvia Angelova Todor Dudev Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1996: Study on the Antifungal Activity of Gallic Acid and Its Azole Derivatives against Fusarium graminearum
In this study, gallic acid (GA), a natural polyphenol, was used to synthesize three azole-modified gallic acid derivatives (AGAs1–3). The antifungal activity of GA and its derivatives against F. graminearum was studied through mycelial growth rate experiments and field efficacy experiments. The results of the mycelial growth rate test showed that the EC50 of AGAs–2 was 0.49 mg/mL, and that of AGAs–3 was 0.42 mg/mL. The biological activity of AGAs–3 on F. graminearum is significantly better than that of GA. The results of field efficacy tests showed that AGAs&n...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Yilin Zheng Yuqi Geng Wenlong Hou Zhe Li Caihong Cheng Xiuping Wang Yuedong Yang Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1998: Preparation of a Novel Oat & beta;-Glucan & ndash;Chromium(III) Complex and Its Hypoglycemic Effect and Mechanism
This study synthesized a novel oat β-glucan (OBG)-Cr(III) complex (OBG-Cr(III)) and explored its structure, inhibitory effects on α-amylase and α-glucosidase, and hypoglycemic activities and mechanism in vitro using an insulin-resistant HepG2 (IR-HepG2) cell model. The Cr(III) content in the complex was found to be 10.87%. The molecular weight of OBG-Cr(III) was determined to be 7.736 × 104 Da with chromium ions binding to the hydroxyl groups of OBG. This binding resulted in the increased asymmetry and altered spatial conformation of the complex along with significant ...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Pengshou Li Yunlu Wang Xiaoting Wang Rui Li Kaihui Wang Yu Jiang Mingyuan Zhang Chuhan Huang Qixiang Ma Jian Sun Jianye Quan Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1999: Gallic Acid Can Promote Low-Density Lipoprotein Uptake in HepG2 Cells via Increasing Low-Density Lipoprotein Receptor Accumulation
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Xuanjun Wang
Gallic acid (GA) is a type of polyphenolic compound that can be found in a range of fruits, vegetables, and tea. Although it has been confirmed it improves non-alcoholic fatty liver disease (NAFLD), it is still unknown whether GA can improve the occurrence of NAFLD by increasing the low-density lipoprotein receptor (LDLR) accumulation and alleviating cholesterol metabolism disorders. Therefore, the present study explored the effect of GA on LDLR and its mechanism of action. The findings indicated that the increase in LDLR accumulation in HepG2 cells induced by GA was associated with the stimulation of...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Dongying Zhang Qixing Zhou Xiangxuan Yang Zhen Zhang Dongxue Wang Dandan Hu Yewei Huang Jun Sheng Xuanjun Wang Tags: Article Source Type: research
Molecules, Vol. 29, Pages 2000: High Reactivity of Dimethyl Ether Activated by Zeolite Ferrierite within a Fer Cage: A Prediction Study
ie Li
The zeolite-catalyzed conversion of DME into chemicals is considered environmentally friendly in industry. The periodic density functional theory, statistical thermodynamics, and the transition state theory are used to study some possible parallel reactions about the hydrogen-bonded DME over zeolite ferrierite. The following are the key findings: (1) the charge separation probably leads to the conversion of a hydrogen-bonded DME into a dimethyl oxonium ion (i.e., DMO+ or (CH3)2OH+) with a positive charge of about 0.804 e; (2) the methylation of DME, CH3OH, H2O, and CO by DMO+ at the T2O6 site of zeolite ferrierit...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Xiaofang Chen Pei Feng Xiujie Li Tags: Article Source Type: research
Molecules, Vol. 29, Pages 2001: Implications of the Propagation Method for the Phytochemistry of Nepeta cataria L. throughout a Growing Season
In this study, we assessed how field-grown catnip plants, transplanted after being propagated via either single-node stem cuttings or seeds, varied regarding their phytochemical composition throughout a growing season in two distinct environmental conditions (Pittstown and Upper Deerfield) in the state of New Jersey, United States. Iridoid terpenes were quantified in plant tissues via ultra-high-performance liquid chromatography with triple quadrupole mass spectrometry (UHPLC-QqQ-MS), and phenolic compounds (phenolic acids and flavonoids) were analyzed via UHPLC with diode-array detection (UHPLC-DAD). The highest contents ...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Erik Nunes Gomes Bo Yuan Harna K. Patel Anthony Lockhart Christian A. Wyenandt Qingli Wu James E. Simon Tags: Article Source Type: research
Molecules, Vol. 29, Pages 2002: Carbon Quantum Dots: Properties, Preparation, and Applications
This article provides an overview of the properties, preparation methods, raw materials for preparation, and the heteroatom doping of carbon quantum dots, and it summarizes the applications in related fields, such as optoelectronics, bioimaging, drug delivery, cancer therapy, sensors, and environmental remediation. Finally, currently encountered issues of carbon quantum dots are presented. The latest research progress in synthesis and application, as well as the challenges outlined in this review, can help and encourage future research on carbon quantum dots. (Source: Molecules)
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Jichuan Kong Yihui Wei Feng Zhou Liting Shi Shuangjie Zhao Mengyun Wan Xiangfeng Zhang Tags: Review Source Type: research
Molecules, Vol. 29, Pages 2003: HPLC-Based Metabolomic Analysis and Characterization of Amaranthus cruentus Leaf and Inflorescence Extracts for Their Antidiabetic and Antihypertensive Potential
. Peraza-Sánchez
Andrés Xingú-López
Víctor Aguilar-Hernández
The aim of this study was to investigate the potential of Amaranthus cruentus flavonoids (quercetin, kaempferol, catechin, hesperetin, naringenin, hesperidin, and naringin), cinnamic acid derivatives (p-coumaric acid, ferulic acid, and caffeic acid), and benzoic acids (vanillic acid and 4-hydroxybenzoic acid) as antioxidants, antidiabetic, and antihypertensive agents. An analytical method for simultaneous quantification of flavonoids, cinnamic acid derivatives, and benzoic acids for metabolomic analysis of leaves and inflorescences from A. cruentus ...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Jes ús Alfredo Araujo-León Ivonne S ánchez-del Pino Rolffy Ortiz-Andrade Sergio Hidalgo-Figueroa Areli Carrera-Lanestosa Ligia Guadalupe Brito-Arg áez Avel Gonz ález-Sánchez Germ án Giácoman-Vallejos Oswaldo Hern ández-Abreu Sergio R. Peraza-S á Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1997: Antioxidant Activity and Effectiveness of Fig Extract in Counteracting Carbon Tetrachloride-Induced Oxidative Damage in Rats
In this study, we assessed hydroethanolic extracts of these fig varieties. The total phenolic content was measured, along with the phenolic profile. Rutin was determined to be the dominant phenolic compound, followed by vanillic acid, 3,4-dihydroxybenzoic acid, quercetin, 4-hydroxybenzoic acid, rosmarinic acid (in Az only), and cinnamic acid. The antioxidant activity of the extracts was evaluated both in vitro (DPPH and FRAP assays) and in vivo, in rats intoxicated with carbon tetrachloride. In all assays, the fig extract—especially the dark-peeled fig variety azendjar—showed antioxidant potency...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Leila Kebal Noureddine Djebli Katarzyna Pokajewicz Nadjet Mostefa Piotr P. Wieczorek Tags: Article Source Type: research
Molecules, Vol. 29, Pages 2004: One-Pot Synthesis of Alkyl Functionalized Reduced Graphene Oxide Nanocomposites as the Lubrication Additive Enabling Enhanced Tribological Performance
ian Jiang
Recently, aiming for the enhanced dispersibility of graphene-based nanomaterials in lubricating oil matrices to serve as highly efficient lubricant additives, numerous modification approaches have been extensively studied. However, these previous modification routes usually involve a tedious multistep modification process or multitudinous toxic reagents, restricting their extensive practical application. In this work, novel graphene oxide (GO) nanoadditives (RGO-g-BO) featuring excellent durable dispersion capability and remarkable tribological performance were successfully prepared via an environmentally fri...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Guangfa Zhang Chao Zhu Yehai Yan Jian Cui Jingxian Jiang Tags: Article Source Type: research
Molecules, Vol. 29, Pages 2005: Potential Targets of Natural Products for Improving Cardiac Ischemic Injury: The Role of Nrf2 Signaling Transduction
Zhang
Myocardial ischemia is the leading cause of health loss from cardiovascular disease worldwide. Myocardial ischemia and hypoxia during exercise trigger the risk of sudden exercise death which, in severe cases, will further lead to myocardial infarction. The Nrf2 transcription factor is an important antioxidant regulator that is extensively engaged in biological processes such as oxidative stress, inflammatory response, apoptosis, and mitochondrial malfunction. It has a significant role in the prevention and treatment of several cardiovascular illnesses, since it can control not only the expression of several an...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Wang Han Dmitrii Zhang Tags: Review Source Type: research
Molecules, Vol. 29, Pages 2006: Novel Star-Shaped Viologens Containing Phenyl and Triphenylamine Moieties for Electrochromic Applications
rab
The two star-shaped viologens containing 1,3,5-substituted phenyl (1) and triphenylamine (2) central cores and n-hexyl chains were synthesized and characterized. Both compounds exhibited promising optoelectronic properties and underwent multiple oxidation/reduction processes resulting in various colors. Four possible redox states of tripyridium salt containing a phenyl or triphenylamine core can occur depending on the applied potentials. The wide color range, from colorless through blue, azure to green-gray, was observed during the electrochemical reduction of compound 1. In the case of compound 2, the color change...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Banasz Wa łęsa-Chorab Tags: Article Source Type: research
