Molecules, Vol. 29, Pages 2007: Pharmacological Potential of Kaempferol, a Flavonoid in the Management of Pathogenesis via Modulation of Inflammation and Other Biological Activities
udi
Rahmani
Natural products and their bioactive compounds have been used for centuries to prevent and treat numerous diseases. Kaempferol, a flavonoid found in vegetables, fruits, and spices, is recognized for its various beneficial properties, including its antioxidant and anti-inflammatory potential. This molecule has been identified as a potential means of managing different pathogenesis due to its capability to manage various biological activities. Moreover, this compound has a wide range of health-promoting benefits, such as cardioprotective, neuroprotective, hepatoprotective, and anti-diabetic, and has a role...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Alrumaihi Almatroodi Alharbi Alwanian Alharbi Almatroudi Rahmani Tags: Review Source Type: research
Molecules, Vol. 29, Pages 2008: Maillard Reaction-Derived S-doped Carbon Dots Promotes Downregulation of PPAR & gamma;, C/EBP & alpha;, and SREBP-1 Genes In-Vitro
In this study, we attempted to create a model system of the Maillard reaction between cystine and glucose using a simple cooking approach. The CDs (CG-CDs) were isolated from cystine-glucose-based Maillard reaction products and characterized using fluorescence spectroscopy, X-ray diffractometer (XRD), and transmission electron microscope (TEM). Furthermore, human mesenchymal stem cells (hMCs) were used as a model to unravel the CDs’ cytotoxic properties. The physiochemical assessment revealed that CG-CDs emit excitation-dependent fluorescence and possess a circular shape with sizes ranging from 2 to 13 nm. CG...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Hanaa Hisham Habelreeh Jegan Athinarayanan Vaiyapuri Subbarayan Periasamy Ali A. Alshatwi Tags: Article Source Type: research
Molecules, Vol. 29, Pages 2010: Systematic Review of Chemical Compounds with Immunomodulatory Action Isolated from African Medicinal Plants
asmané Semde
A robust, well-functioning immune system is the cornerstone of good health. Various factors may influence the immune system’s effectiveness, potentially leading to immune system failure. This review aims to provide an overview of the structure and action of immunomodulators isolated from African medicinal plants. The research was conducted according to PRISMA guidelines. Full-text access research articles published in English up to December 2023, including plant characteristics, isolated phytochemicals, and immuno-modulatory activities, were screened. The chemical structures of the isolated ...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Wendwaoga Ars ène Nikiema Moussa Ou édraogo Windbedma Prisca Ou édraogo Souleymane Fofana Boris Honor é Amadou Ouédraogo Talwendpanga Edwige Delma Belem Amad é Gambo Moustapha Abdoulaye Aim é Serge Sawadogo Raogo Ou édraogo Rasman é Semde Tags: Systematic Review Source Type: research
Molecules, Vol. 29, Pages 2009: Green Preparation and Antibacterial Activity Evaluation of AgNPs-Blumea balsamifera Oil Nanoemulsion
This study aimed to rapidly prepare a new type of green antibacterial nanoemulsion containing silver nanoparticles in one step by using Blumea balsamifera oil (BBO) as an oil phase and tea saponin (TS) as a natural emulsifier and reducing agent. The optimum preparation conditions of the AgNPs@BBO-TS NE were determined, as well as its physicochemical properties and antibacterial activity in vitro being investigated. The results showed that the average particle size of the AgNPs@BBO-TS NE was 249.47 ± 6.23 nm, the PDI was 0.239 ± 0.003, and the zeta potential was −35.82 &pl...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Chunfang Ma Bingnan Liu Lingfeng Du Wei Liu Yue Zhu Teng Chen Zuhua Wang Hongpeng Chen Yuxin Pang Tags: Article Source Type: research
Molecules, Vol. 29, Pages 2011: Objective Quantification Technique and Widely Targeted Metabolomics-Based Analysis of the Effects of Different Saccharidation Processes on Preserved French Plums
This study aimed to investigate the distinctive metabolites in samples from various stages of the processing of preserved French plums. The PCF4 exhibited the highest appearance, overall taste, and chroma. Furthermore, utilizing UPLC and ESI-Q TRAP-MS/MS, a comprehensive examination of the metabolome in the processing of preserved French plums was conducted. A total of 1776 metabolites were analyzed. Using WGCNA, we explored metabolites associated with sensory features through 10 modules. Based on this, building the correlation of modules and objective quantification metrics yielded three key modules. After screening for 1...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Yan Dong Yang Wang Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1985: Design and Synthesis of Dimethylaminomethyl-Substituted Curcumin Derivatives: Potent Anti-Inflammatory, Anti-Oxidant, and Radioprotection Activity, Improved Aqueous Solubility Compared with Curcumin
Shuchen Liu
Although the wide variety of bioactivities of curcumin has been reported by researchers, the clinical application of curcumin is still limited due to its poor aqueous solubility. In view of this, a series of dimethylaminomethyl-substituted curcumin derivatives were designed and synthesized (compounds 1–15). Acetate of these derivatives were prepared (compounds 1a–15a). The Mannich reaction and aldol condensation reaction are the main reactions involved in this study. Compounds 6, 10, 12, 3a, 5a, 6a, 7a, 8a, 10a, 11a, 12a, 13a, 14a, and 15a exhibited better in vitro anti-inflamm...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Huiling Gu Sifan Liu Kai Liang Ziming Xia Guangjie Zhang Bin Li Shuchen Liu Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1987: Co/SiO2 Catalyst for Methoxycarbonylation of Acetylene: On Catalytic Performance and Active Species
in Wang
Reppe carbonylation of acetylene is an atom-economic and non-petroleum approach to synthesize acrylic acid and acrylate esters, which are key intermediates in the textile, leather finishing, and polymer industries. In the present work, a noble metal-free Co@SiO2 catalyst was prepared and evaluated in the methoxycarbonylation reaction of acetylene. It was discovered that pretreatment of the catalyst by different reductants (i.e., C2H2, CO, H2, and syngas) greatly improved the catalytic activity, of which Co/SiO2-H2 demonstrated the best performance under conditions of 160 °C, 0.05 MPa C2H2, 4 MPa CO,...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: An Wang Hongchen Cao Leilei Zhang Aiqin Wang Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1986: Unveiling the Untapped Potential of Bertagnini & rsquo;s Salts in Microwave-Assisted Synthesis of Quinazolinones
Molecules, Vol. 29, Pages 1986: Unveiling the Untapped Potential of Bertagnini’s Salts in Microwave-Assisted Synthesis of Quinazolinones
Molecules doi: 10.3390/molecules29091986
Authors:
Shyamal Kanti Bera
Sourav Behera
Lidia De Luca
Francesco Basoccu
Rita Mocci
Andrea Porcheddu
Microwave-assisted organic synthesis (MAOS) has emerged as a transformative technique in organic chemistry, significantly enhancing the speed, efficiency, and selectivity of chemical reactions. In our research, we have employed microwave irradiation to expedite the synthesis of quinazolinones, using water as an eco-frien...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Shyamal Kanti Bera Sourav Behera Lidia De Luca Francesco Basoccu Rita Mocci Andrea Porcheddu Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1988: Uniform P-Doped MnMoO4 Nanosheets for Enhanced Asymmetric Supercapacitors Performance
In this study, MnMoO4·H2O nanosheets were synthesized on nickel foam via a hydrothermal route, and the MnMoO4·H2O nanosheet structure was successfully doped with a phosphorus element using a gas–solid reaction method. Phosphorus element doping forms phosphorus–metal bonds and oxygen vacancies, thereby increasing the charge storage and conductivity of the electrode material. The specific capacitance value is as high as 2.112 F cm−2 (1760 F g−1) at 1 mA cm−2, which is 3.2 times higher than that of the MnMoO4·H2O...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Yu Liu Yan Li Zhuohao Liu Tao Feng Huichuan Lin Gang Li Kaiying Wang Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1989: Comprehensive Two-Dimensional Gas Chromatography with a TOF MS Detector & mdash;An Effective Tool to Trace the Signature of Grape Varieties
Molecules, Vol. 29, Pages 1989: Comprehensive Two-Dimensional Gas Chromatography with a TOF MS Detector—An Effective Tool to Trace the Signature of Grape Varieties
Molecules doi: 10.3390/molecules29091989
Authors:
Daniela Fonseca
Nuno Martins
Raquel Garcia
Maria João Cabrita
Varietal volatile compounds are characteristic of each variety of grapes and come from the skins of the grapes. This work focuses on the development of a methodology for the analysis of free compounds in grapes from Trincadeira, Cabernet Sauvignon, Syrah, Castelão and Tinta Barroca from the 2021 and 2022 harvests...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Daniela Fonseca Nuno Martins Raquel Garcia Maria Jo ão Cabrita Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1990: Synthesis, Structure and Antibacterial Activity of Two Novel Coordination Polymers Based on N,N & prime;-bis(4-carbozvlbenzvl)-4-aminotoluene and Heterocyclic Ligand against S. aureus
Molecules, Vol. 29, Pages 1990: Synthesis, Structure and Antibacterial Activity of Two Novel Coordination Polymers Based on N,N′-bis(4-carbozvlbenzvl)-4-aminotoluene and Heterocyclic Ligand against S. aureus
Molecules doi: 10.3390/molecules29091990
Authors:
Ziyun Wang
Lun Zhao
Hongwei Jing
Guanying Song
Jiayu Li
As the use of antibiotics increases, the increasing resistance of bacteria is the main reason for the reduced efficiency of antibacterial drugs, making the research of new antibacterial materials become new hot spot. In this article, two novel coordination polymers (CPs), namely, [Cd2(L)2(...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Ziyun Wang Lun Zhao Hongwei Jing Guanying Song Jiayu Li Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1991: Palladium-Catalyzed Esterification of Aryl Fluorosulfates with Aryl Formates
Zhi-Liang Shen
An efficient palladium-catalyzed carbonylation of aryl fluorosulfates with aryl formates for the facile synthesis of esters was developed. The cross-coupling reactions proceeded effectively in the presence of a palladium catalyst, phosphine ligand, and triethylamine in DMF to produce the corresponding esters in moderate to good yields. Of note, functionalities or substituents, such as nitro, cyano, methoxycarbonyl, trifluoromethyl, methylsulfonyl, trifluoromethoxy, fluoro, chloro, bromo, methyl, methoxy, N,N-dimethyl, and [1,3]dioxolyl, were well-tolerated in the reactions, which could be kept for lat...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Xue Chen Yuan Liang Wen-Wen Wang Chengping Miao Xue-Qiang Chu Weidong Rao Hao Xu Xiaocong Zhou Zhi-Liang Shen Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1984: A Review of Ultrasonic Treatment in Mineral Flotation: Mechanism and Recent Development
ng
Song
Ultrasonic treatment has been widely used in the mineral flotation process due to its advantages in terms of operational simplicity, no secondary pollutant formation, and safety. Currently, many studies have reported the effect of ultrasonic treatment on mineral flotation and shown excellent flotation performance. In this review, the ultrasonic mechanisms are classified into three types: the transient cavitation effect, stable cavitation effect, and acoustic radiation force effect. The effect of the main ultrasonic parameters, including ultrasonic power and ultrasonic frequency, on mineral flotation are disc...
Source: Molecules - April 25, 2024 Category: Chemistry Authors: Zhang Du Hu Zhang Song Tags: Review Source Type: research
Molecules, Vol. 29, Pages 1962: Conformation Analysis and Stereodynamics of Symmetrically ortho-Disubstituted Carvacrol Derivatives
ssilev
The design and synthesis of analogs of natural products can be a valuable source of medicinal preparations for the pharmaceutical industry. In the present study, the structural elucidation of eleven derivatives of 2,4-dihalogeno substituted synthetic analogues of the natural compound carvacrol was carried out by means of NMR experiments, and of another thirteen by DFT calculations. By selective NOE experiments and the irradiation of CH signals of the isopropyl group, individual conformers were assigned as syn and anti. By comparing GIAO/B3LYP/6-311++G(d,p)-calculated and experimentally measured vicinal 3JCH spin...
Source: Molecules - April 25, 2024 Category: Chemistry Authors: Miljana R. Đorđević Zlatković Niko S. Radulovi ć Miroslav Dangalov Nikolay G. Vassilev Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1963: Y(OTf)3-Salazin-Catalyzed Asymmetric Aldol Condensation
iaxi Xu
The chiral aziridine-containing vicinal iminophenol tridentate ligands (named salazins) are a class of readily prepared chiral ligands from enantiopure aziridines and salicylaldehydes. Their scandium and yttrium triflate complexes show excellent reactivity and enantioselectivities in the catalytic asymmetric aldol condensation of electron-deficient aromatic aldehydes and ketones, including acetone and cycloalkanones. The stereoselectivity is rationalized to the strong π–stacking interaction between aromatic aldehydes and the vicinal iminophenol group in the chiral ligands. (Source: Molecules)
Source: Molecules - April 25, 2024 Category: Chemistry Authors: Chengzhuo Wang Ning Chen Zhanhui Yang Jiaxi Xu Tags: Article Source Type: research
