Molecules, Vol. 29, Pages 1823: The DBB Family in Populus trichocarpa: Identification, Characterization, Evolution and Expression Profiles
In this study, the identity, classification, structures, conserved motifs, chromosomal location, cis elements, duplication events, and expression profiles of the PtrDBB genes were analyzed in the woody model plant Populus trichocarpa. Here, 12 PtrDBB genes (PtrDBB1–PtrDBB12) were identified and classified into four distinct groups, and all of them were homogeneously spread among eight out of seventeen poplar chromosomes. The collinearity analysis of the DBB family genes from P. trichocarpa and two other species (Z. mays and A. thaliana) indicated that segmental duplication gene pairs and high-level conservati...
Source: Molecules - April 17, 2024 Category: Chemistry Authors: Ruihua Wu Yuxin Li Lin Wang Zitian Li Runbin Wu Kehang Xu Yixin Liu Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1825: The Future of Graphene: Preparation from Biomass Waste and Sports Applications
Zhang
At present, the main raw material for producing graphene is graphite ore. However, researchers actively seek alternative resources due to their high cost and environmental problems. Biomass waste has attracted much attention due to its carbon-rich structure and renewability, emerging as a potential raw material for graphene production to be used in sports equipment. However, further progress is required on the quality of graphene produced from waste biomass. This paper, therefore, summarizes the properties, structures, and production processes of graphene and its derivatives, as well as the inherent advantages of...
Source: Molecules - April 17, 2024 Category: Chemistry Authors: Yueting Wu Yanlong Li Xiangyang Zhang Tags: Review Source Type: research
Molecules, Vol. 29, Pages 1826: Expanding Predictive Capacities in Toxicology: Insights from Hackathon-Enhanced Data and Model Aggregation
This study aimed to investigate the roles of gradient boosting and strategic data aggregation in enhancing the predictivity ability of models for the toxicity of small organic molecules. We focused on evaluating the impact of incorporating fragment features and expanding the chemical space, facilitated by a comprehensive dataset procured in an open hackathon. We used gradient boosting techniques, accounting for critical features such as the structural fragments or functional groups often associated with manifestations of toxicity. (Source: Molecules)
Source: Molecules - April 17, 2024 Category: Chemistry Authors: Dmitrii O. Shkil Alina A. Muhamedzhanova Philipp I. Petrov Ekaterina V. Skorb Timur A. Aliev Ilya S. Steshin Alexander V. Tumanov Alexander S. Kislinskiy Maxim V. Fedorov Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1827: The Prediction of LptA and LptC Protein & ndash;Protein Interactions and Virtual Screening for Potential Inhibitors
Molecules, Vol. 29, Pages 1827: The Prediction of LptA and LptC Protein–Protein Interactions and Virtual Screening for Potential Inhibitors
Molecules doi: 10.3390/molecules29081827
Authors:
Yixin Ren
Wenting Dong
Yan Li
Weiting Cao
Zengshuo Xiao
Ying Zhou
Yun Teng
Xuefu You
Xinyi Yang
Huoqiang Huang
Hao Wang
Antibiotic resistance in Gram-negative bacteria remains one of the most pressing challenges to global public health. Blocking the transportation of lipopolysaccharides (LPS), a crucial component of the outer membrane of Gram-negative bacteria, is considered a promising strategy for...
Source: Molecules - April 17, 2024 Category: Chemistry Authors: Yixin Ren Wenting Dong Yan Li Weiting Cao Zengshuo Xiao Ying Zhou Yun Teng Xuefu You Xinyi Yang Huoqiang Huang Hao Wang Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1824: Influence of SPION Surface Coating on Magnetic Properties and Theranostic Profile
This study aimed to develop multifunctional nanoplatforms for both cancer imaging and therapy using superparamagnetic iron oxide nanoparticles (SPIONs). Two distinct synthetic methods, reduction–precipitation (MR/P) and co-precipitation at controlled pH (MpH), were explored, including the assessment of the coating’s influence, namely dextran and gold, on their magnetic properties. These SPIONs were further functionalized with gadolinium to act as dual T1/T2 contrast agents for magnetic resonance imaging (MRI). Parameters such as size, stability, morphology, and magnetic behavior were evaluated b...
Source: Molecules - April 17, 2024 Category: Chemistry Authors: Vital Cruvinel Ferreira-Filho Beatriz Morais Bruno J. C. Vieira Jo ão Carlos Waerenborgh Maria Jo ão Carmezim Csilla No émi Tóth Sandra M ême Sara Lacerda Daniel Jaque C élia T. Sousa Maria Paula Cabral Campello Laura C. J. Pereira Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1828: Optimization of Extraction Process and Analysis of Biological Activity of Flavonoids from Leaves of Cultivated & lsquo;Qi-Nan & rsquo; Agarwood
Molecules, Vol. 29, Pages 1828: Optimization of Extraction Process and Analysis of Biological Activity of Flavonoids from Leaves of Cultivated ‘Qi-Nan’ Agarwood
Molecules doi: 10.3390/molecules29081828
Authors:
Qingle Li
Penglian Wei
Yingjian Li
Yunlin Fu
Currently, the planting of ‘Qi-Nan’ is continuously increasing, yet a substantial amount of ‘Qi-Nan’ leaves have not been properly exploited. To improve the ‘Qi-Nan’ tree ’s utilization value, ‘Qi-Nan’ leaves were ...
Source: Molecules - April 17, 2024 Category: Chemistry Authors: Qingle Li Penglian Wei Yingjian Li Yunlin Fu Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1829: Phytochemical Analysis, Antimicrobial Screening and In Vitro Pharmacological Activity of Artemisia vestita Leaf Extract
jay Yadav
Artemisia vestita Wall. Ex Besser is a folklore medicinal plant that belongs to Asteraceae family and a treasure trove of drugs. The aim of this research study was to investigate the phytoconstituents, antimicrobial activity, antioxidant, anti-inflammatory, cytotoxicity and wound healing potential of A. vestita leaf extract (ALE). Phytochemical analysis of the ALE was carried out by Soxhlet extraction and GCMS (gas chromatography–mass spectrometry) analysis. Antimicrobial activity was performed by the agar well diffusion method against selected bacterial and fungal strains. Free radical scavengi...
Source: Molecules - April 17, 2024 Category: Chemistry Authors: Shivani Dogra Bhupendra Koul Joginder Singh Meerambika Mishra Dhananjay Yadav Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1830: Onosma bracteatum Wall Aqueous & ndash;Ethanolic Extract Suppresses Complete Freund & rsquo;s Adjuvant-Induced Arthritis in Rats via Regulation of TNF- & alpha;, IL-6, and C-Reactive Protein
This study aimed to evaluate the anti-arthritic effects of the aqueous–ethanolic extract of O. bracteatum leaves (AeOB) in a rat model of complete Freund’s adjuvant (CFA)-induced arthritis. Rats were treated with AeOB (250, 500, and 750 mg/kg), indomethacin (10 mg/kg), or a vehicle control from days 8 to 28 post-CFA injection. Arthritic score, paw diameter, and body weight were monitored at regular intervals. X-ray radiographs and histopathological analysis were performed to assess arthritic severity. Inflammatory cytokines tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6),...
Source: Molecules - April 17, 2024 Category: Chemistry Authors: Farah Zafar Ghazala Shaheen Hafiz Muhammad Asif Mohd Farhan Ghazala Muteeb Mohammad Aatif Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1831: Isolation of Extracellular Outer Membrane Vesicles (OMVs) from Escherichia coli Using EVscore47 Beads
In this study, EVscore47 multifunctional chromatography microspheres were synthesized and used to efficiently isolate functional OMVs from Escherichia coli. Through this technology, OMV loss can be kept to a minimum, and OMVs can be harvested using EVscore47 at 11-fold higher yields and ~13-fold higher purity than those achieved by means of ultracentrifugation. Based on the results presented here, we propose a novel EVscore47-based isolation of OMVs that is fast and scalable. (Source: Molecules)
Source: Molecules - April 17, 2024 Category: Chemistry Authors: Gongming Shi Xiaohong Yang Jikai Wang Wenjing Wei Kecui Hu Xingyue Huang Yanfei Qiu Yun He Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1834: Anti-Cracking TEOS-Based Hybrid Materials as Reinforcement Agents for Paper Relics
In this study, dodecyltrimethoxysilane (DTMS) was introduced into TEOS to minimize this shrinkage by adding elastic long chains to weaken the capillary forces. The gel formed from the DTMS/TEOS hybrid material was transparent and crack-free, featuring a dense microstructure without mesopores or micropores. It exhibited excellent thermal stability, with a glass transition temperature of up to 109.64 °C. Evaluation experiments were conducted on artificially aged, handmade bamboo paper. The TEOS-based hybrid material effectively combined with the paper fibers through the sol–gel process, polymerizing...
Source: Molecules - April 17, 2024 Category: Chemistry Authors: Mengruo Wu Le Mu Zhiyue Zhang Xiangna Han Hong Guo Liuyang Han Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1835: Identification of Leishmania donovani PEX5-PTS1 Interaction Inhibitors through Fluorescence Polarization-Based High-Throughput Screening
In this study, we focused on identifying small molecule inhibitors which prevents the interaction between peroxin 5 (PEX5) and peroxisomal targeting signal 1 (PTS1), pivotal for kinetoplastid parasite survival. The Leishmania donovani PEX5, containing a C-terminal tetratricopeptide repeat (TPR) domain, was expressed and purified, followed by the quantification of kinetic parameters of PEX5-PTS1 interactions. A fluorescence polarization-based high-throughput screening assay was developed and small molecules inhibiting the LdPEX5-PTS1 interaction were discovered through the screening of a library of 51,406 compounds. Based o...
Source: Molecules - April 17, 2024 Category: Chemistry Authors: Trong-Nhat Phan Kyu-Ho Paul Park David Shum Joo Hwan No Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1832: 26SCS-Loaded SilMA/Col Composite Sponge with Well-Arranged Layers Promotes Angiogenesis-Based Diabetic Wound Repair by Mediating Macrophage Inflammatory Response
nyu Yang
Mei Tu
Diabetic wound healing is a significant clinical challenge because abnormal immune cells in the wound cause chronic inflammation and impair tissue regeneration. Therefore, regulating the behavior and function of macrophages may be conducive to improving treatment outcomes in diabetic wounds. Herein, sulfated chitosan (26SCS)-containing composite sponges (26SCS-SilMA/Col-330) with well-arranged layers and high porosity were constructed based on collagen and silk fibroin, aiming to induce an appropriate inflammatory response and promote angiogenesis. The results indicated that the ordered topological st...
Source: Molecules - April 17, 2024 Category: Chemistry Authors: Pin Luo Wei Liu Zhangyao Ye Yuyu Zhang Zekun Zhang Jing Yi Rong Zeng Shenyu Yang Mei Tu Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1833: ZIF-67-Derived Flexible Sulfur Cathode with Improved Redox Kinetics for High-Performance Li-S Batteries
Xuejie Gao
Lithium–sulfur (Li-S) batteries have received much attention due to their high energy density and low price. In recent years, alleviating the volume expansion and suppressing the shuttle effect during the charge and discharge processes of Li-S batteries have been widely addressed. However, the slow conversion kinetics from polysulfide (LiPSs) to Li2S2/Li2S still limits the application of Li-S batteries. Therefore, we designed a ZIF-67 grown on cellulose (named ZIF-67@CL) as an electrocatalyst to improve the interconversion kinetics from LiPSs to Li2S2/Li2S for Li-S batteries. Based on the re...
Source: Molecules - April 17, 2024 Category: Chemistry Authors: Chen Cheng Hanyan Wu Xinyang Chen Shuiping Cai Yingkang Tian Xiaofei Yang Xuejie Gao Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1813: Surface Charge Effects for the Hydrogen Evolution Reaction on Pt(111) Using a Modified Grand-Canonical Potential Kinetics Method
This study provides a practical method for obtaining accurate grand-canonical reaction energetics and analyzing the surface charge induced changes. (Source: Molecules)
Source: Molecules - April 17, 2024 Category: Chemistry Authors: Shaoyu Kong Min Ouyang Yi An Wei Cao Xiaobo Chen Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1814: Antioxidant Activity of Foods and Natural Products
eban
Today, there is growing recognition of the importance of antioxidants in promoting human health and well-being [...] (Source: Molecules)
Source: Molecules - April 17, 2024 Category: Chemistry Authors: Jos é Pinela Maria In ês Dias Carla Pereira Jos é Ignacio Alonso-Esteban Tags: Editorial Source Type: research
