Molecules, Vol. 29, Pages 1765: Evaluation of Urtica dioica Phytochemicals against Therapeutic Targets of Allergic Rhinitis Using Computational Studies
llo
Allergic rhinitis (AR) is a prevalent inflammatory condition affecting millions globally, with current treatments often associated with significant side effects. To seek safer and more effective alternatives, natural sources like Urtica dioica (UD) are being explored. However, UD’s mechanism of action remains unknown. Therefore, to elucidate it, we conducted an in silico evaluation of UD phytochemicals’ effects on known therapeutic targets of allergic rhinitis: histamine receptor 1 (HR1), neurokinin 1 receptor (NK1R), cysteinyl leukotriene receptor 1 (CLR1), chemoattractant receptor-homo...
Source: Molecules - April 12, 2024 Category: Chemistry Authors: Erick Bahena Culhuac Martiniano Bello Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1767: Research Progress and Application Prospects of Solid-State Hydrogen Storage Technology
ao Ding
Solid-state hydrogen storage technology has emerged as a disruptive solution to the “last mile” challenge in large-scale hydrogen energy applications, garnering significant global research attention. This paper systematically reviews the Chinese research progress in solid-state hydrogen storage material systems, thermodynamic mechanisms, and system integration. It also quantitatively assesses the market potential of solid-state hydrogen storage across four major application scenarios: on-board hydrogen storage, hydrogen refueling stations, backup power supplies, and power grid peak s...
Source: Molecules - April 12, 2024 Category: Chemistry Authors: Yaohui Xu Yang Zhou Yuting Li Zhao Ding Tags: Review Source Type: research
Molecules, Vol. 29, Pages 1768: Bioactive & alpha;-Pyrone Analogs from the Endophytic Fungus Diaporthe sp. CB10100: & alpha;-Glucosidase Inhibitory Activity, Molecular Docking, and Molecular Dynamics Studies
Molecules, Vol. 29, Pages 1768: Bioactive α-Pyrone Analogs from the Endophytic Fungus Diaporthe sp. CB10100: α-Glucosidase Inhibitory Activity, Molecular Docking, and Molecular Dynamics Studies
Molecules doi: 10.3390/molecules29081768
Authors:
Wang
Ma
Wu
Zhong
Feng
Huang
Li
Tang
Huang
Pu
Two α-pyrone analogs were isolated from the endophytic fungus Diaporthe sp. CB10100, which is derived from the medicinal plant Sinomenium acutum. These analogs included a new compound, diaporpyrone F (3), and a known compound, diaporpyrone D (4). The structure of 3 was i...
Source: Molecules - April 12, 2024 Category: Chemistry Authors: Wang Ma Wu Zhong Feng Huang Li Tang Huang Pu Tags: Communication Source Type: research
Molecules, Vol. 29, Pages 1745: Sterol Derivatives Specifically Increase Anti-Inflammatory Oxylipin Formation in M2-like Macrophages by LXR-Mediated Induction of 15-LOX
ge Schebb
The understanding of the role of LXR in the regulation of macrophages during inflammation is emerging. Here, we show that LXR agonist T09 specifically increases 15-LOX abundance in primary human M2 macrophages. In time- and dose-dependent incubations with T09, an increase of 3-fold for ALOX15 and up to 15-fold for 15-LOX-derived oxylipins was observed. In addition, LXR activation has no or moderate effects on the abundance of macrophage marker proteins such as TLR2, TLR4, PPARγ, and IL-1RII, as well as surface markers (CD14, CD86, and CD163). Stimulation of M2-like macrophages with FXR and RXR a...
Source: Molecules - April 12, 2024 Category: Chemistry Authors: Reiichi Ohno Malwina Mainka Rebecca Kirchhoff Nicole M. Hartung Nils Helge Schebb Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1747: The Impact of Different Drying Methods on the Metabolomic and Lipidomic Profiles of Arthrospira platensis
rewicz
Drying is an inseparable part of industrial microalgae production. In this work, the impacts of eight different drying methods on the metabolome and lipidome of Arthrospira platensis were investigated. The studied drying methods were freeze drying (FD), sun drying (SD), air drying at 40 and 75 °C (AD′ and AD″), infrared drying at 40 and 75 °C (IRD′ and IRD″), and vacuum drying at 40 and 75 °C (VD′ and VD″). Results gathered by reversed-phase liquid chromatography separation coupled with high-re...
Source: Molecules - April 12, 2024 Category: Chemistry Authors: Marika Mr óz Karol Parchem Joanna J óźwik M. Ros ário Domingues Barbara Kusznierewicz Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1746: Nanoscale Evaluation of the Degradation Stability of Black Phosphorus Nanosheets Functionalized with PEG and Glutathione-Stabilized Doxorubicin Drug-Loaded Gold Nanoparticles in Real Functionalized System
ura
Two-dimensional black phosphorus (2D BP) has attracted significant research interest in the field of biomedical applications due to its unique characteristics, including high biocompatibility, impressive drug-loading efficiency, phototherapeutic ability, and minimal side effects. However, its puckered honeycomb lattice structure with lone-pair electrons of BP leads to higher sensitivity and chemical reactivity towards H2O and O2 molecules, resulting in the degradation of the structure with physical and chemical changes. In our study, we synthesize polyethylene glycol (PEG) and glutathione-stabilized doxorubicin dru...
Source: Molecules - April 12, 2024 Category: Chemistry Authors: Thisari Maleesha Gunathilaka Masaru Shimomura Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1748: Diverse Co(II) Coordination Polymers with the Same Mixed Ligands: Evaluation of Chemical Stability and Structural Transformation
er Chen
Reactions of Co(OAc)2·4H2O, N‚N’-bis(3-pyridylmethyl)oxalamide (L) and 4,4′-sulfonyldibenzoic acid (H2SDA) afforded four coordination polymers with the same mixed ligands, {[Co(L)(SDA)(H2O)2]·H2O·CH3OH}n, 1, {[Co(L)0.5(SDA)]·2H2O·0.5L}n, 2, {[Co(L)1.5(SDA)(H2O)]·H2O}n, 3, and {[Co2(L)1.5(SDA)2(H2O)2]·4H2O}n, 4, which have been structurally characterized using single-crystal X-ray crystallography. Complexes 1–4 are 2D layers, revealing topologies of sql,...
Source: Molecules - April 12, 2024 Category: Chemistry Authors: Chia-Yi Lee Yu-Hui Ye Song-Wei Wang Jhy-Der Chen Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1749: Detecting Pathogenic Phytophthora Species Using Volatile Organic Compounds
This study utilized a volatilomics approach (solid-phase microextraction coupled to gas chromatography–mass spectrometry) to differentiate between several Phytophthora species in culture and discriminate between healthy and Phytophthora-inoculated European beech and pedunculate oak trees. We tentatively identified 14 compounds that could differentiate eight Phytophthora species from each other in vitro. All of the Phytophthora species examined, except Phytophthora cambivora, uniquely produced at least one compound not observed in the other species; however, most detected compounds were shared between multiple...
Source: Molecules - April 12, 2024 Category: Chemistry Authors: Patrick Sherwood Ida Nordstr öm Steve Woodward Bj örn Bohman Michelle Cleary Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1750: Effects of Torulaspora delbrueckii and Saccharomyces cerevisiae Co-Fermentation on the Physicochemical and Flavor Compounds of Huaniu Apple Cider
njiang Kang
The effects of different fermentation methods utilizing Torulaspora delbrueckii 1004 and Saccharomyces cerevisiae 32169 on the physicochemical properties, organic acid content, polyphenol and flavonoid concentrations, antioxidant activity, and volatile aroma compounds of Huaniu apple cider were investigated in this study. Employing methods of single inoculation, co-inoculation, and sequential inoculation, it was found that sequential fermentation exhibited strong fermentative power in the initial stages, effectively reducing the content of soluble solids and achieving a balanced composition of malic, succin...
Source: Molecules - April 12, 2024 Category: Chemistry Authors: Chaozhen Zeng Yuwen Mu Jing Yuan Haiyan Zhang Juan Song Sanjiang Kang Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1751: Exploration of Polysaccharides from Phyllanthus emblica: Isolation, Identification, and Evaluation of Antioxidant and Anti-Glycolipid Metabolism Disorder Activities
In this study, we extracted and purified polysaccharides from Phyllanthus emblica and thoroughly analyzed their structure using various techniques, including NMR, methylation analysis, and surface-enhanced Raman spectroscopy. We investigated the hypolipidemic and anti-glycolipid metabolism disorder activity of Phyllanthus emblica polysaccharides for the first time utilizing oleic acid (OA) and advanced glycation end products (AGEs) as inducers. Additionally, the antioxidant activity of Phyllanthus emblica polysaccharides was assessed in vitro. These findings lay the groundwork for future investigations into the potential a...
Source: Molecules - April 12, 2024 Category: Chemistry Authors: Peng Guo Meng Chen Wenzhao Wang Qiuyun Li Xinyu Chen Jiayue Liang Yiyang He Yanli Wu Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1752: A Portrait of the Chromophore as a Young System & mdash;Quantum-Derived Force Field Unraveling Solvent Reorganization upon Optical Excitation of Cyclocurcumin Derivatives
Molecules, Vol. 29, Pages 1752: A Portrait of the Chromophore as a Young System—Quantum-Derived Force Field Unraveling Solvent Reorganization upon Optical Excitation of Cyclocurcumin Derivatives
Molecules doi: 10.3390/molecules29081752
Authors:
Raúl Losantos
Giacomo Prampolini
Antonio Monari
The study of fast non-equilibrium solvent relaxation in organic chromophores is still challenging for molecular modeling and simulation approaches, and is often overlooked, even in the case of non-adiabatic dynamics simulations. Yet, especially in the case of photoswitches, the interaction with the environment ca...
Source: Molecules - April 12, 2024 Category: Chemistry Authors: Ra úl Losantos Giacomo Prampolini Antonio Monari Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1753: The Repellent Capacity against Sitophilus zeamais (Coleoptera: Curculionidae) and In Vitro Inhibition of the Acetylcholinesterase Enzyme of 11 Essential Oils from Six Plants of the Caribbean Region of Colombia
rez
The repellent capacity against Sitophilus zeamais and the in vitro inhibition on AChE of 11 essential oils, isolated from six plants of the northern region of Colombia, were assessed using a modified tunnel-type device and the Ellman colorimetric method, respectively. The results were as follows: (i) the degree of repellency (DR) of the EOs against S. zeamais was 20–68% (2 h) and 28–74% (4 h); (ii) the IC50 values on AChE were 5–36 µg/mL; likewise, the %inh. on AChE (1 µg/cm3 per EO) did not show any effect in 91% of the EO tested; (iii) six EOs ...
Source: Molecules - April 12, 2024 Category: Chemistry Authors: Amner Mu ñoz-Acevedo Mar ía C. González Jes ús E. Alonso Karen C. Fl órez Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1754: Heavy Metal Removal from Aqueous Solutions Using a Customized Bipolar Membrane Electrodialysis Process
In conclusion, this process efficiently separates HMs from aqueous solutions. It showed the features of diluate pH adjustment, reduction in the overall stack electrical resistance, and contribution of anion exchange membranes in multivalent cation removal. The mechanisms involved in HMs removal were diffusion and migration from the bulk solution, followed by their sorption on both cation and anion exchange membranes. (Source: Molecules)
Source: Molecules - April 12, 2024 Category: Chemistry Authors: Samuel Bunani Gudrun Abbt-Braun Harald Horn Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1755: Supercritical CO2 Extraction of Fatty Acids, Phytosterols, and Volatiles from Myrtle (Myrtus communis L.) Fruit
lbino
Background: Myrtle (Myrtus communis L.) is a coastal Mediterranean aromatic medicinal plant rich in essential oil components, flavonoids, and phenolic acids. Studies highlight the potential health benefits of myrtle bioactive compounds with antioxidant and antiproliferative properties. Since limited research exists on myrtle fruit’s lipid fraction, the aim of this study was to apply supercritical CO2 extraction to obtain bioactive compounds from myrtle berries focusing on the fatty acids, sterols, and essential oils. Methods: The optimization of the supercritical CO2 extraction of myrtle fruit using...
Source: Molecules - April 12, 2024 Category: Chemistry Authors: Daniela Cvitkovi ć Iva Škarica Verica Dragovi ć-Uzelac Sandra Balbino Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1726: Basic Sites on Alumina with Preadsorbed Ethanol and Ammonia & mdash;An IR Study
Molecules, Vol. 29, Pages 1726: Basic Sites on Alumina with Preadsorbed Ethanol and Ammonia—An IR Study
Molecules doi: 10.3390/molecules29081726
Authors:
Jerzy Podobiński
Jerzy Datka
The adsorption of ethanol and ammonia changes the basic properties of alumina, and new basic sites are created. Ethanol reacts with surface Al-OH groups, forming ethoxy group Al-O-C2H5. The substitution of Al-OH by Al-O-C2H5 increases the negative charge of neighbouring oxygen atoms, and they became sufficiently basic to react with adsorbed CO2 forming carbonate species CO32−. These carbonates were found to b...
Source: Molecules - April 11, 2024 Category: Chemistry Authors: Jerzy Podobi ński Jerzy Datka Tags: Article Source Type: research
