Molecules, Vol. 29, Pages 1795: The Fast Quantification of Vitamin B12 in Milk Powder by High-Performance Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry
This study presents a new technique for determining vitamin B12 in milk powder using high-performance liquid chromatography-inductively coupled plasma mass spectrometry (HPLC-ICP-MS). We used ultrasonics with potassium ferrocyanide and zinc acetate solutions to extract the samples. 59Co was employed as the analytical target for cyanocobalamin. It was separated using a Phenomenex Luna 5 μm C18 (250 × 4.6 mm) chromatographic column with a mobile phase consisting of 1.6 mmol/L EDTA and 0.4 mmol/L KH2PO4 in a 60% v/v methanol solution (pH = 4.0). The sample has an excellent separating degree for free c...
Source: Molecules - April 15, 2024 Category: Chemistry Authors: Yang Zhou Zheng Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1796: From Potential Prebiotic Synthons to Useful Chiral Scaffolds: A Synthetic and Structural Reinvestigation of 2-Amino-Aldononitriles
alacios
This paper explores and revisits in detail the formation and characterization of sugar-based aminonitriles, whose ultimate origin can be traced to the interaction of biomolecules with cyanide. Although the synthesis and spectroscopic data of 2-amino-aldononitriles were reported long ago, there are both contradictory and confusing results among the published data. We have now addressed this concern through an exhaustive structural elucidation of acylated 2-amino- and 2-alkyl(aryl)amino-2-deoxyaldonitriles using mass spectrometry and FT-IR, FT–Raman, and NMR spectroscopies. Several structures could ...
Source: Molecules - April 15, 2024 Category: Chemistry Authors: Esther Matamoros Mark E. Light Pedro Cintas Juan C. Palacios Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1786: ZnO-CeO2 Hollow Nanospheres for Selective Determination of Dopamine and Uric Acid
This study provides a valuable strategy for the synthesis of ZnO-CeO2 hollow nanospheres via the hard templating method as electrocatalysts for the selective detection of dopamine and uric acid. (Source: Molecules)
Source: Molecules - April 15, 2024 Category: Chemistry Authors: Yaru Zhang Xiaoxia Yan Yifan Chen Dongmei Deng Haibo He Yunyi Lei Liqiang Luo Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1787: An Innovative Methodology to Characterize, at the Molecular Scale, Interactions in Polysaccharide Aqueous Solutions
Grisel
Characterizing molecular interactions at the microscopic level remains difficult and, therefore, represents a key target to better understand macromolecule and biomacromolecule behaviors in solution, alone, or in mixtures with others. Therefore, accurate characterization in liquid media, especially in aqueous solutions, without causing any perturbation of the system in which they are studied, is quite difficult. To this purpose, the present paper describes an innovative methodology based on fluorescence spectrophotometry. Two molecular fluorescent probes, namely 8-anilino-1-naphtalenesulfonic acid (ANS) and 2-b...
Source: Molecules - April 15, 2024 Category: Chemistry Authors: Alexandre Cordinier Igor Petukhov Nicolas Hucher Michel Grisel Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1789: Artemisinin Confers Cytoprotection toward Hydrogen Peroxide-Induced Cell Apoptosis in Retinal Pigment Epithelial Cells in Correlation with the Increased Acetylation of Histone H4 at Lysine 8
In conclusion, these results confirmed our hypothesis and indicated that Artemisinin attenuated H2O2-induced apoptosis in apparent correlation with the increase in the Acetyl-H4 (Lys 8) level, which is associated with gene transcription and cell survival. By modulating histone acetylation, Artemisinin may restore the balance between acetylation and deacetylation and enhance the resistance and survival of RPE cells under oxidative stress. Our study provides novel mechanistic insights into the effect of Artemisinin on histone acetylation and apoptosis in RPE cells and supports the potential application of Artemisinin in the ...
Source: Molecules - April 15, 2024 Category: Chemistry Authors: Chao Yang Lijun Ge Xiyong Yu Philip Lazarovici Wenhua Zheng Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1788: A Comprehensive Evaluation of Dioxins and Furans Occurrence in River Sediments from a Secondary Steel Recycling Craft Village in Northern Vietnam
Truong Ngoc
Minh Quang Bui
This first study investigated the presence of dioxins and furans in river sediments around a craft village in Vietnam, focusing on Secondary Steel Recycling. Sediment samples were collected from various locations along the riverbed near the Da Hoi Secondary Steel Recycling village in Bac Ninh province. The analysis was conducted using a HRGC/HRMS-DFS device, detecting a total of 17 dioxin/furan isomers in all samples, with an average total concentration of 288.86 ng/kg d.w. The concentrations of dioxin/furan congeners showed minimal variation among sediment samples, ranging from 253.9 to 3...
Source: Molecules - April 15, 2024 Category: Chemistry Authors: Hung Xuan Nguyen Xuyen Thi Nguyen Hang Thi Hong Mai Huong Thi Nguyen Nam Duc Vu Thao Thi Phuong Pham Trung Quang Nguyen Dat Tien Nguyen Nam Thanh Duong Anh Le Tuan Hoang Tung Ngoc Nguyen Nhan Van Le Ha Viet Dao Minh Truong Ngoc Minh Quang Bui Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1790: Diastereoselective Three-Component 1,3-Dipolar Cycloaddition to Access Functionalized & beta;-Tetrahydrocarboline- and Tetrahydroisoquinoline-Fused Spirooxindoles
Molecules, Vol. 29, Pages 1790: Diastereoselective Three-Component 1,3-Dipolar Cycloaddition to Access Functionalized β-Tetrahydrocarboline- and Tetrahydroisoquinoline-Fused Spirooxindoles
Molecules doi: 10.3390/molecules29081790
Authors:
Yongchao Wang
Yu Chen
Shengli Duan
Yiyang Cao
Wenjin Sun
Mei Zhang
Delin Zhao
Donghua Hu
Jianwei Dong
A chemselective catalyst-free three-component 1,3-dipolar cycloaddition has been described. The unique polycyclic THPI and THIQs were creatively employed as dipolarophiles, which led to the formation of functionalized β-tetrahydrocarboline- an...
Source: Molecules - April 15, 2024 Category: Chemistry Authors: Yongchao Wang Yu Chen Shengli Duan Yiyang Cao Wenjin Sun Mei Zhang Delin Zhao Donghua Hu Jianwei Dong Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1791: Obacunone, a Promising Phytochemical Triterpenoid: Research Progress on Its Pharmacological Activity and Mechanism
e Wang
Rong Shi
Obacunone, a natural triterpenoid, is an active component of the herbs Dictamnus dasycarpus Turcz. and Phellodendron amurense Rupr, and an indicator of the herbs’ quality. Owing to its multiple health benefits, several studies have investigated the multi-targeting potential action mechanisms of obacunone. To summarize recent developments on the pharmacological actions of obacunone and focus on the underlying molecular mechanisms and signaling networks, we searched PubMed, Europe PMC, Wiley Online Library, Web of Science, Google Scholar, Wanfang Medical Network, and China National Knowled...
Source: Molecules - April 15, 2024 Category: Chemistry Authors: Yuyang Zhou Jifeng Gu Jiahui Li Huishan Zhang Mei Wang Yuanyuan Li Tianming Wang Jiajie Wang Rong Shi Tags: Review Source Type: research
Molecules, Vol. 29, Pages 1792: Modeling Studies of the Mechanism of Context-Dependent Bidirectional Movements of Kinesin-14 Motors
ie
Kinesin-14s, a subfamily of the large superfamily of kinesin motor proteins, function mainly in spindle assembly and maintenance during mitosis and meiosis. KlpA from Aspergillus nidulans and GiKIN14a from Giardia intestinalis are two types of kinesin-14s. Available experimental results puzzlingly showed that while KlpA moves preferentially toward the minus end in microtubule-gliding setups and inside parallel microtubule overlaps, it moves preferentially toward the plus end on single microtubules. More puzzlingly, the insertion of an extra polypeptide linker in the central region of the neck stalk switches the moti...
Source: Molecules - April 15, 2024 Category: Chemistry Authors: Xie Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1793: Saponins of Paris polyphylla for the Improvement of Acne: Anti-Inflammatory, Antibacterial, Antioxidant and Immunomodulatory Effects
g
Quan An
Acne is a chronic inflammatory skin disease with a recurring nature that seriously impacts patients’ quality of life. Currently, antibiotic resistance has made it less effective in treating acne. However, Paris polyphylla (P. polyphylla) is a valuable medicinal plant with a wide range of chemical components. Of these, P. polyphylla saponins modulate the effects in vivo and in vitro through antibacterial, anti-inflammatory, immunomodulatory, and antioxidant effects. Acne is primarily associated with inflammatory reactions, abnormal sebum function, micro-ecological disorders, hair follicle hyper...
Source: Molecules - April 15, 2024 Category: Chemistry Authors: Luyao Li Jiachan Zhang Wenjing Cheng Feiqian Di Changtao Wang Quan An Tags: Review Source Type: research
Molecules, Vol. 29, Pages 1780: Study on the Design, Synthesis, Bioactivity and Translocation of the Conjugates of Phenazine-1-carboxylic Acid and N-Phenyl Alanine Ester
g Zhu
Junkai Li
The natural pesticide phenazine-1-carboxylic acid (PCA) is known to lack phloem mobility, whereas Metalaxyl is a representative phloem systemic fungicide. In order to endow PCA with phloem mobility and also enhance its antifungal activity, thirty-two phenazine-1-carboxylic acid-N-phenylalanine esters conjugates were designed and synthesized by conjugating PCA with the active structure N-acylalanine methyl ester of Metalaxyl. All target compounds were characterized by 1H NMR, 13C NMR and HRMS. The antifungal evaluation results revealed that several target compounds exhibited moderate to potent antifung...
Source: Molecules - April 14, 2024 Category: Chemistry Authors: Yiran Wu Guoqing Mao Gaoshan Xing Yao Tian Yong Hu Changzhou Liao Li Li Xiang Zhu Junkai Li Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1781: Enhancing the Quality of Low-Alcohol Navel Orange Wine through Simultaneous Co-Fermentation Using Saccharomyces cerevisiae SC-125, Angel Yeast SY, and Lactiplantibacillus plantarum BC114
In this study, using Jintang navel orange juice as the raw material, multi-microbial fermentation was conducted with Saccharomyces cerevisiae SC-125 and Angel yeast SY, as well as Lactiplantibacillus plantarum BC114. Single yeast and co-fermentation with Lactiplantibacillus plantarum were used as the control groups. The research aimed to investigate the physicochemical parameters of navel orange wine during fermentation. Additionally, headspace solid-phase microextraction gas chromatography–mass spectrometry (HP-SPME-GC-MS) was employed to determine and analyze the types and levels of flavor compounds in the ...
Source: Molecules - April 14, 2024 Category: Chemistry Authors: Hua Xiong Yingyue Zhang Wanting Wang Hong Ye Qing Zhang Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1782: Design, Synthesis, and Biological Evaluation of Novel Tetrahydroacridin Hybrids with Sulfur-Inserted Linkers as Potential Multitarget Agents for Alzheimer & rsquo;s Disease
Molecules, Vol. 29, Pages 1782: Design, Synthesis, and Biological Evaluation of Novel Tetrahydroacridin Hybrids with Sulfur-Inserted Linkers as Potential Multitarget Agents for Alzheimer’s Disease
Molecules doi: 10.3390/molecules29081782
Authors:
Xiuyuan Wu
Xiaotong Ze
Shuai Qin
Beiyu Zhang
Xinnan Li
Qi Gong
Haiyan Zhang
Zheying Zhu
Jinyi Xu
Alzheimer’s disease (AD) is a complex neurodegenerative disease that can lead to the loss of cognitive function. The progression of AD is regulated by multiple signaling pathways and their associated targets. Therefore, multitarget strate...
Source: Molecules - April 14, 2024 Category: Chemistry Authors: Xiuyuan Wu Xiaotong Ze Shuai Qin Beiyu Zhang Xinnan Li Qi Gong Haiyan Zhang Zheying Zhu Jinyi Xu Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1783: Photoinduced Site-Selective Aryl C-H Borylation with Electron-Donor-Acceptor Complex Derived from B2Pin2 and Isoquinoline
Tian-Yu Sun
Due to boron’s metalloid properties, aromatic boron reagents are prevalent synthetic intermediates. The direct borylation of aryl C-H bonds for producing aromatic boron compounds offers an appealing, one-step solution. Despite significant advances in this field, achieving regioselective aryl C-H bond borylation using simple and readily available starting materials still remains a challenge. In this work, we attempted to enhance the reactivity of the electron-donor-acceptor (EDA) complex by selecting different bases to replace the organic base (NEt3) used in our previous research. To our deli...
Source: Molecules - April 14, 2024 Category: Chemistry Authors: Manhong Li Yi-Hui Deng Qianqian Chang Jinyuan Li Chao Wang Leifeng Wang Tian-Yu Sun Tags: Communication Source Type: research
Molecules, Vol. 29, Pages 1784: BiMPADR: A Deep Learning Framework for Predicting Adverse Drug Reactions in New Drugs
i Cao
Kang Li
Detecting the unintended adverse reactions of drugs (ADRs) is a crucial concern in pharmacological research. The experimental validation of drug–ADR associations often entails expensive and time-consuming investigations. Thus, a computational model to predict ADRs from known associations is essential for enhanced efficiency and cost-effectiveness. Here, we propose BiMPADR, a novel model that integrates drug gene expression into adverse reaction features using a message passing neural network on a bipartite graph of drugs and adverse reactions, leveraging publicly available data. By combini...
Source: Molecules - April 14, 2024 Category: Chemistry Authors: Shuang Li Liuchao Zhang Liuying Wang Jianxin Ji Jia He Xiaohan Zheng Lei Cao Kang Li Tags: Article Source Type: research
