Molecules, Vol. 29, Pages 1828: Optimization of Extraction Process and Analysis of Biological Activity of Flavonoids from Leaves of Cultivated & lsquo;Qi-Nan & rsquo; Agarwood

Molecules, Vol. 29, Pages 1828: Optimization of Extraction Process and Analysis of Biological Activity of Flavonoids from Leaves of Cultivated ‘Qi-Nan’ Agarwood Molecules doi: 10.3390/molecules29081828 Authors: Qingle Li Penglian Wei Yingjian Li Yunlin Fu Currently, the planting of ‘Qi-Nan’ is continuously increasing, yet a substantial amount of ‘Qi-Nan’ leaves have not been properly exploited. To improve the ‘Qi-Nan’ tree ’s utilization value, ‘Qi-Nan’ leaves were used as a raw material. An ultrasound-assisted method was performed to obtain the flavonoids from the ’Qi-Nan’ leaves, followed by optimization of the extraction factors using a one-way and response surface methodology to enhance the extraction of flavonoids. Subsequently, the composition of the flavonoids, as well as their bioactive abilities, were analyzed by ultra-high-performance liquid chromatography–mass spectrometry (UHPLC-MS) and in vitro activity testing methods. The findings demonstrated that a 1:50 material-to-liquid ratio, 60% ethanol concentration, and ultrasound-assisted extraction time of 30 min were the ideal procedures for extracting flavonoids (flavonoid content: 6.68%). Meanwhile, the ‘Qi-Nan’ leaves possessed the antioxidant and medicinal potential to prevent diabetes a...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research