PET identifies tau's origin in Alzheimer's disease
An automated PET image analysis method can track the development of tau protein...Read more on AuntMinnie.comRelated Reading: PET shows aerobic exercise has little effect on amyloid PET links poor air quality to presence of amyloid plaque Tau Alzheimer's blood test gives PET a run for its money Emerging PET tracer excels at tau pathology, differentiates dementias Impaired blood flow linked to tau buildup in AD patients (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - January 21, 2021 Category: Radiology Source Type: news

What Are the 7 Stages of Dementia?
Title: What Are the 7 Stages of Dementia?Category: Diseases and ConditionsCreated: 1/21/2021 12:00:00 AMLast Editorial Review: 1/21/2021 12:00:00 AM (Source: MedicineNet Alzheimer)
Source: MedicineNet Alzheimer - January 21, 2021 Category: Geriatrics Source Type: news

Is your brain sleep deprived? Low mood, depression and even Alzheimer's can be linked to tiredness
Neurosurgeon Dr Sanjay Gupta believes preventing the onset of Alzheimer's and mitigating its symptoms is within our grasp - and getting enough sleep is key. (Source: the Mail online | Health)
Source: the Mail online | Health - January 21, 2021 Category: Consumer Health News Source Type: news

A Tweak to Immune Cells Reverses Aging in Mice
Knocking out the receptor for a lipid that causes inflammation rejuvenates macrophage metabolism and restores cognitive function in an Alzheimer's disease model. (Source: The Scientist)
Source: The Scientist - January 20, 2021 Category: Science Tags: News & Opinion Source Type: news

Blood Biomarker May Predict Alzheimer's Disease Progression Blood Biomarker May Predict Alzheimer's Disease Progression
Changes in plasma levels of p-tau181 are associated with progressive cognitive decline and reduction in gray matter volume in patients with amyloid beta.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - January 20, 2021 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Blood Biomarker May Predict Alzheimer's Disease Progression Blood Biomarker May Predict Alzheimer's Disease Progression
Changes in plasma levels of p-tau181 are associated with progressive cognitive decline and reduction in gray matter volume in patients with amyloid beta.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - January 20, 2021 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

How do you die from dementia?
DEMENTIA is a common neurodegenerative condition that is more likely to develop as you get older, and Alzheimer's disease is the most common type of dementia in the UK. Can you die from dementia, and how do you die from dementia? (Source: Daily Express - Health)
Source: Daily Express - Health - January 20, 2021 Category: Consumer Health News Source Type: news

PET shows aerobic exercise has little effect on amyloid
While aerobic exercise is good for the cardiovascular system, PET images show...Read more on AuntMinnie.comRelated Reading: PET links poor air quality to presence of amyloid plaque PET links lower sleep levels with Alzheimer's risk Amyloid PET results prompt adults to rethink their future FDG-PET shows where exercise could stall Alzheimer's FDG-PET links physical activity to healthy brains (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - January 20, 2021 Category: Radiology Source Type: news

Automated imaging reveals where TAU protein originates in the brain in Alzheimer's disease
(American Association for the Advancement of Science) Researchers have developed an automated method that can track the development of harmful clumps of TAU protein related to Alzheimer's disease in the brain, according to work involving 443 individuals. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 20, 2021 Category: International Medicine & Public Health Source Type: news

Food to fuel up your mind: How to keep your brain finely tuned on the S.H.A.R.P. diet
Neurosurgeon Dr Sanjay Gupta believes preventing the onset of Alzheimer's and mitigating its symptoms is within our grasp - and it starts with how we fuel our bodies. (Source: the Mail online | Health)
Source: the Mail online | Health - January 20, 2021 Category: Consumer Health News Source Type: news

Seattle biotech AltPep closes $23M funding round for Alzheimer ’s research
Seattle biotech AltPep Corp. closed a $23 million series A funding round last week, which will go toward its Alzheimer ’s research. The biotech is a portfolio company of IntuitiveX, a Seattle life science incubator. Altpep's board of directors also made several additions, including Adaptive Biotechnologies CEO Chad Robins; David Goel, managing general partner and founded of Matrix Capital Management; and Joel Mar cus, executive chairman and founder of Alexandria Real Estate Equities and Alexandria… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - January 19, 2021 Category: Pharmaceuticals Authors: Megan Campbell Source Type: news

Seattle biotech AltPep closes $23M funding round for Alzheimer ’s research
Seattle biotech AltPep Corp. closed a $23 million series A funding round last week, which will go toward its Alzheimer ’s research. The biotech is a portfolio company of IntuitiveX, a Seattle life science incubator. Altpep's board of directors also made several additions, including Adaptive Biotechnologies CEO Chad Robins; David Goel, managing general partner and founded of Matrix Capital Management; and Joel Mar cus, executive chairman and founder of Alexandria Real Estate Equities and Alexandria… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - January 19, 2021 Category: Biotechnology Authors: Megan Campbell Source Type: news

Type of Alzheimer's With Intact Memory Offers New Research Paths Type of Alzheimer's With Intact Memory Offers New Research Paths
Patients with primary progressive aphasia-associated Alzheimer's seem to be more resilient to effects of neurofibrillary tangles in the brain, a new study shows.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - January 19, 2021 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Type of Alzheimer's With Intact Memory Offers New Research Paths Type of Alzheimer's With Intact Memory Offers New Research Paths
Patients with primary progressive aphasia-associated Alzheimer's seem to be more resilient to effects of neurofibrillary tangles in the brain, a new study shows.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - January 18, 2021 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Memory Preserved in Rare Aphasia Tied to Alzheimer Disease
Decline in language function, but not episodic memory, seen for primary progressive aphasia associated with Alzheimer disease (Source: The Doctors Lounge - Psychiatry)
Source: The Doctors Lounge - Psychiatry - January 15, 2021 Category: Psychiatry Tags: Neurology, Pathology, Psychiatry, Geriatrics, Journal, Source Type: news

2 Million People Have Died From COVID-19 Worldwide
In coming years, families around the world will be reminded of what happened in January 2021 by gaps in photo albums, saved video chats or text message threads, and in some cases, tragically, empty seats at future weddings. But in the history books, the pandemic’s impact will be traced in terms of milestones, including one passed on Friday: 2 million people have died from the COVID-19 pandemic, according to the Johns Hopkins Coronavirus Resource Center. The novel coronavirus has caused the deadliest global epidemic since the emergence of HIV/AIDS 40 years ago, and the deadliest respiratory pandemic in a century. ...
Source: TIME: Health - January 15, 2021 Category: Consumer Health News Authors: Tara Law Tags: Uncategorized COVID-19 Source Type: news

Memory Preserved in Rare Aphasia Tied to Alzheimer Disease
FRIDAY, Jan. 15, 2021 -- Individuals with primary progressive aphasia (PPA) associated with Alzheimer disease (AD) have longitudinally preserved episodic memory, according to a study published online Jan. 13 in Neurology. M. Marsel-Mesulam, M.D.,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 15, 2021 Category: Pharmaceuticals Source Type: news

Aphasia Affects Brain Similar to Alzheimer's, But Without Memory Loss
Title: Aphasia Affects Brain Similar to Alzheimer's, But Without Memory LossCategory: Health NewsCreated: 1/13/2021 12:00:00 AMLast Editorial Review: 1/14/2021 12:00:00 AM (Source: MedicineNet Alzheimer)
Source: MedicineNet Alzheimer - January 14, 2021 Category: Geriatrics Source Type: news

Following the hops of disordered proteins could lead to future treatments of Alzheimer's disease
(University of Cambridge) Researchers from the University of Cambridge, the University of Milan and Google Research have used machine learning techniques to predict how proteins, particularly those implicated in neurological diseases, completely change their shapes in a matter of microseconds. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 14, 2021 Category: International Medicine & Public Health Source Type: news

MicroRNA may serve as therapeutic targets for traumatic brain injury
(Walter Reed Army Institute of Research) WRAIR scientists have shown that traumatic brain injury causes coordinated microRNA dysregulation followed by increased amounts of the beta-site amyloid cleaving enzyme, or BACE1, and loss of amyloid precursor protein. BACE-1 cleaves APP to generate amyloid beta peptides, a hallmark of neurodegenerative disease pathology and brain cells loss, which are the focus of several clinical trials for Alzheimer's disease. Future research will characterize the direct role of miRNAs and their relationship to BACE1 within TBI. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 14, 2021 Category: International Medicine & Public Health Source Type: news

A cascade of NO in Alzheimer's disease
(Source: ScienceNOW)
Source: ScienceNOW - January 14, 2021 Category: Science Authors: Ray, L. B. Tags: Cell Biology, Medicine, Diseases twis Source Type: news

Noncanonical transnitrosylation network contributes to synapse loss in Alzheimers disease
Here we describe mechanistically distinct enzymes (a kinase, a guanosine triphosphatase, and a ubiquitin protein hydrolase) that function in disparate biochemical pathways and can also act in concert to mediate a series of redox reactions. Each enzyme manifests a second, noncanonical function—transnitrosylation—that triggers a pathological biochemical cascade in mouse models and in humans with Alzheimer’s disease (AD). The resulting series of transnitrosylation reactions contributes to synapse loss, the major pathological correlate to cognitive decline in AD. We conclude that enzymes with distinct primary...
Source: ScienceNOW - January 14, 2021 Category: Science Authors: Nakamura, T., Oh, C.-k., Liao, L., Zhang, X., Lopez, K. M., Gibbs, D., Deal, A. K., Scott, H. R., Spencer, B., Masliah, E., Rissman, R. A., Yates, J. R., Lipton, S. A. Tags: Cell Biology, Medicine, Diseases, Online Only r-articles Source Type: news

Aphasia Affects Brain Similar to Alzheimer's, But Without Memory Loss
WEDNESDAY, Jan. 13, 2021 -- A rare brain disease that causes loss of language skills doesn't lead to memory loss, a new study finds. The condition is called primary progressive aphasia and about 40% of people who have it have underlying Alzheimer's... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - January 13, 2021 Category: General Medicine Source Type: news

New studies support blood test for early detection of Alzheimer's disease
(University of Gothenburg) In three recent publications in Molecular Psychiatry, Brain and JAMA Neurology researchers from the University of Gothenburg provide convincing evidence that an in-house developed blood test for Alzheimer's disease can detect the disease early and track its course, which has major implications for a potential use in clinical practice and treatment trials. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 13, 2021 Category: International Medicine & Public Health Source Type: news

MIND and Mediterranean diets associated with later onset of Parkinson's disease
(University of British Columbia) A new study from UBC researchers suggests a strong correlation between following the MIND and Mediterranean diets and later onset of Parkinson's disease (PD). While researchers have long known of neuroprotective effects of the MIND diet for diseases like Alzheimer's and dementia, this study is the first to suggest a link between this diet and brain health for Parkinson's disease (PD). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 13, 2021 Category: International Medicine & Public Health Source Type: news

Approximately half of AD dementia cases are mild, one-fifth are severe
(Boston University School of Medicine) What percent of patients with Alzheimer's Disease (AD) currently have severe dementia? Do more people have mild disease? Or are the majority suffering with moderate dementia? A new study using data from the Framingham Heart Study (FHS) sheds light on these trends. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 13, 2021 Category: International Medicine & Public Health Source Type: news

New report estimates 10,000 people 65 and older living with dementia in nation's capital
(George Washington University) A report released today estimates that about 10,000 Washington, DC residents 65 and older are living with dementia, a general term for a range of memory loss disorders, including Alzheimer's disease. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - January 13, 2021 Category: International Medicine & Public Health Source Type: news

Experimental Drug for Alzheimer Disease Shows Promise
TUESDAY, Jan. 12, 2021 -- Drug maker Eli Lilly on Monday announced promising results from a small study of an experimental Alzheimer disease drug called donanemab. The two-year, phase 2 clinical trial included 272 patients with mild-to-moderate... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 12, 2021 Category: Pharmaceuticals Source Type: news

Rotten egg gas could guard against Alzheimer's disease
(Johns Hopkins Medicine) Typically characterized as poisonous, corrosive and smelling of rotten eggs, hydrogen sulfide's reputation may soon get a face-lift thanks to Johns Hopkins Medicine researchers. In experiments in mice, researchers have shown the foul-smelling gas may help protect aging brain cells against Alzheimer's disease. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - January 12, 2021 Category: International Medicine & Public Health Source Type: news

Positive Topline Data for Lilly's Donanemab in Early Alzheimer's Positive Topline Data for Lilly's Donanemab in Early Alzheimer's
Donanemab, which targets a modified form of amyloid, slowed decline of a composite measure of cognition and function by 32% relative to placebo, topline phase 2 results show.Medscape Medical News (Source: Medscape FamilyMedicine Headlines)
Source: Medscape FamilyMedicine Headlines - January 11, 2021 Category: Primary Care Tags: Neurology & Neurosurgery News Source Type: news

Eli Lilly's Alzheimer's Drug Shows Promise in Small Trial
Participants with the disease still declined, but much more slowly than those receiving a placebo, investigators say. (Source: NYT Health)
Source: NYT Health - January 11, 2021 Category: Consumer Health News Authors: Gina Kolata Tags: Alzheimer ' s Disease Drugs (Pharmaceuticals) Clinical Trials Research Eli Lilly and Company donanemab Source Type: news

Including unhealthy foods may diminish positive effects of an otherwise healthy diet
(Rush University Medical Center) Researchers at Rush University Medical Center have reported diminished benefits of a Mediterranean diet among those with high frequency of eating unhealthy foods. The results of their study were published inAlzheimer's& Dementia: The Journal of the Alzheimer's Association on Jan. 7. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 8, 2021 Category: International Medicine & Public Health Source Type: news

Protein that can be toxic in the heart and nerves may help prevent Alzheimer's
(UT Southwestern Medical Center) A protein that wreaks havoc in the nerves and heart when it clumps together can prevent the formation of toxic protein clumps associated with Alzheimer's disease, a new study led by a UT Southwestern researcher shows. The findings, published recently in the Journal of Biological Chemistry, could lead to new treatments for this brain-ravaging condition, which currently has no truly effective therapies and no cure. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 7, 2021 Category: International Medicine & Public Health Source Type: news

What are the performance limits of our brain?
(Otto-von-Guericke-Universit ä t Magdeburg) Which neurobiological principles prevent us from fully utilizing our own cognitive abilities andhow can limitations that occur in old age or with Alzheimer's disease be diminished? The German Research Foundation (DFG) has awarded University of Magdeburg 14 million euros for its Collaborative Research Center CRC 1436 'Neural Resources of Cognition'. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - January 7, 2021 Category: International Medicine & Public Health Source Type: news

Covid latest: Could COVID-19 spur on Alzheimer's? What the research suggests so far
CORONAVIRUS efforts are currently focused on arresting the spread of the new mutations. However, researchers are also examining the long-term effects of COVID-19, chewing on a question that could have profound implications later on in life: Could COVID-19 increase Alzheimer's risk? (Source: Daily Express - Health)
Source: Daily Express - Health - January 6, 2021 Category: Consumer Health News Source Type: news

Alzheimer's Disease
Title: Alzheimer's DiseaseCategory: Diseases and ConditionsCreated: 8/26/2008 12:00:00 AMLast Editorial Review: 1/6/2021 12:00:00 AM (Source: MedicineNet Alzheimer)
Source: MedicineNet Alzheimer - January 6, 2021 Category: Geriatrics Source Type: news

A prognostic Alzheimer's disease blood test in the symptom-free stage
(Ruhr-University Bochum) Using a blood test, a German-Dutch research team has predicted the risk of Alzheimer's disease in people who were clinically diagnosed as not having Alzheimer's disease but who perceived themselves as cognitively impaired (Subjective Cognitive Declined, SCD). The researchers analyzed blood samples from an SCD cohort supervised at the Alzheimer Center Amsterdam. Using a test developed in Bochum, they identified all 22 subjects at study entry who developed Alzheimer's dementia, thus the clinical symptoms, within six years. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - January 6, 2021 Category: International Medicine & Public Health Source Type: news

Alzheimer ’s researchers consider brain metals, iron needs closer look
NIEHS scientists found metals levels in brain fluid do not represent frontal cortex levels, and samples from Alzheimer’s patients had more iron. (read more) (Source: Environmental Factor - NIEHS Newsletter)
Source: Environmental Factor - NIEHS Newsletter - January 6, 2021 Category: Environmental Health Source Type: news

Seafood consumption may reduce risk of Alzheimer ’s despite mercury
New research found links between seafood consumption by some older adults and fewer signs of Alzheimer’s, despite higher levels of mercury. (read more) (Source: Environmental Factor - NIEHS Newsletter)
Source: Environmental Factor - NIEHS Newsletter - January 6, 2021 Category: Environmental Health Source Type: news

Race/ethnic differences in social resources as cognitive risk and protective factors - Katz B, Turney I, Lee JH, Amini R, Ajrouch KJ, Antonucci TC.
Overall social network size, often the sum of common lifetime relationships, including children, family, and friends, has been linked to cognitive impairment and Alzheimer's Disease. However, little research has examined the association between network siz... (Source: SafetyLit)
Source: SafetyLit - January 5, 2021 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Journal article reviews century of data showing COVID-19 likely to impact the brain
(University of Texas Health Science Center at San Antonio) Decades of data paint a compelling case for why COVID-19 survivors, even those with few symptoms, could experience long-term effects on the brain and central nervous system. A global research program supported by the Alzheimer's Association includes researchers from the Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases at The University of Texas Health Science Center at San Antonio. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - January 5, 2021 Category: Infectious Diseases Source Type: news

Routine eye scans may give clues to cognitive decline in diabetes
(Joslin Diabetes Center) As they age, people with diabetes are more likely to develop Alzheimer's disease and other cognitive disorders than are people without diabetes. Scientists at Joslin Diabetes Center now have shown that routine eye imaging can identify changes in the retina that may be associated with cognitive disorders in older people with type 1 diabetes.These results may open up a relatively easy method for early detection of cognitive decline in this population. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 5, 2021 Category: International Medicine & Public Health Source Type: news

ADDF presents vision of a consortium to accelerate research into speech and language biomarkers for Alzheimer's disease
(Alzheimer's Drug Discovery Foundation) In a commentary in Exploration in Medicine, Alzheimer's experts lay out a vision for a worldwide research consortium that can give clinicians -- and patients -- the answers to which speech and language changes may signal Alzheimer's in the form of digital biomarkers. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 5, 2021 Category: International Medicine & Public Health Source Type: news

Like father like son: how brain health can traverse generations
Your father's exercise routine may have made you smarter according to EU-funded researchers studying how lifestyle choices affect brain function and memory. The findings could lead to new treatments for neurodegenerative conditions such as Alzheimer's disease. (Source: EUROPA - Research Information Centre)
Source: EUROPA - Research Information Centre - January 5, 2021 Category: Research Source Type: news

Cognoptix Appoints New Chief Medical Officer, Dr. Carl Sadowsky, MD, And Chief Financial Officer, Mike Kaswan, MBA, To Management Team
MARLBOROUGH, Mass., Jan. 4, 2021 -- (Healthcare Sales & Marketing Network) -- Cognoptix, a leading diagnostics company dedicated to the early detection of Alzheimer's disease (AD), announces two appointments to its senior management team. Dr. Carl H. Sado... Diagnostics, Neurology, Personnel Cognoptix, Alzheimer's disease (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - January 4, 2021 Category: Pharmaceuticals Source Type: news

New USC study on circadian clock shows " junk DNA " plays a key role in regulating rhythms
(Keck School of Medicine of USC) Researchers have been trying to figure out what regulates molecular circadian clocks, in search of new insights into diseases like Alzheimer's, cancer and diabetes. Until now, that research has focused on what is known as clock genes. But new research reveals the discovery of a new cog in the circadian clock - a genome-wide regulatory layer made up of small chains of non-coding nucleotides known as micro RNAS (miRNAs). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 4, 2021 Category: International Medicine & Public Health Source Type: news

Dementia: Weight training could protect parts of the brain vulnerable to Alzheimer’s
DEMENTIA could be prevented through exercise according to researchers. One study demonstrated how weight training could protect parts of the brain vulnerable to Alzheimer's disease (Source: Daily Express - Health)
Source: Daily Express - Health - January 2, 2021 Category: Consumer Health News Source Type: news

Dementia symptoms: The early warning signs of Alzheimer's disease
DEMENTIA is an umbrella term used to describe various brain diseases, with the most common being Alzheimer's disease. What are the earliest warning signs of the condition? (Source: Daily Express - Health)
Source: Daily Express - Health - December 31, 2020 Category: Consumer Health News Source Type: news

Glucose metabolism: a link between traumatic brain injury and Alzheimer's disease - Xu XJ, Yang MS, Zhang B, Niu F, Dong JQ, Liu BY.
Traumatic brain injury (TBI), a growing public health problem, is a leading cause of death and disability worldwide, although its prevention measures and clinical cares are substantially improved. Increasing evidence shows that TBI may increase the risk ... (Source: SafetyLit)
Source: SafetyLit - December 30, 2020 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Middle-Age Sleep Patterns Tied to Subsequent Cognitive Decline
MONDAY, Dec. 28, 2020 -- Longer time to fall asleep is associated with greater subsequent cognitive decline among middle-aged Hispanic adults, according to a study published online Dec. 22 in Alzheimer's& Dementia. Christian Agudelo, M.D., from... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - December 28, 2020 Category: Pharmaceuticals Source Type: news