Molecules, Vol. 29, Pages 2003: HPLC-Based Metabolomic Analysis and Characterization of Amaranthus cruentus Leaf and Inflorescence Extracts for Their Antidiabetic and Antihypertensive Potential

Molecules, Vol. 29, Pages 2003: HPLC-Based Metabolomic Analysis and Characterization of Amaranthus cruentus Leaf and Inflorescence Extracts for Their Antidiabetic and Antihypertensive Potential Molecules doi: 10.3390/molecules29092003 Authors: Jesús Alfredo Araujo-León Ivonne Sánchez-del Pino Rolffy Ortiz-Andrade Sergio Hidalgo-Figueroa Areli Carrera-Lanestosa Ligia Guadalupe Brito-Argáez Avel González-Sánchez Germán Giácoman-Vallejos Oswaldo Hernández-Abreu Sergio R. Peraza-Sánchez Andrés Xingú-López Víctor Aguilar-Hernández The aim of this study was to investigate the potential of Amaranthus cruentus flavonoids (quercetin, kaempferol, catechin, hesperetin, naringenin, hesperidin, and naringin), cinnamic acid derivatives (p-coumaric acid, ferulic acid, and caffeic acid), and benzoic acids (vanillic acid and 4-hydroxybenzoic acid) as antioxidants, antidiabetic, and antihypertensive agents. An analytical method for simultaneous quantification of flavonoids, cinnamic acid derivatives, and benzoic acids for metabolomic analysis of leaves and inflorescences from A. cruentus was developed with HPLC-UV-DAD. Evaluation of linearity, limit of detection, limit of quantitation, precision, and recovery was used to validate the analytical method developed. Maximum total flavonoids contents (5.2 mg/g of lyophilized material) and cinnamic acid derivatives contents (0.6 mg/g of lyophilized material) were found in leaves. Using UV-Vis spectrophoto...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research