'Time machine' offers new pancreatic cancer drug testing approach
(Purdue University) Drug resistance is a major reason why pancreatic cancer has a five-year survival rate of only about 10%. If scientists tested potential drugs on multiple tumor cell subtypes rather than on just one subtype, they may be able to catch resistance better, suggests a " time machine " developed by Purdue University engineers. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 29, 2020 Category: International Medicine & Public Health Source Type: news

Domestic violence and assault leading to isolated grade III pancreatic injury managed conservatively; a rare case report - Hariprasad CP, Gupta R, Kumar A.
INTRODUCTION: Isolated complete pancreatic transection following blunt trauma abdomen is associated with very high mortality. Conservative management in such a scenario is a rare experience. Majority of the patients with American Association for Surgery of... (Source: SafetyLit)
Source: SafetyLit - October 27, 2020 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Pancreatic Ascites Managed With a Conservative Approach Pancreatic Ascites Managed With a Conservative Approach
This case of massive ascites in a patient with chronic pancreatitis secondary to chronic alcohol use was successfully managed with a combination of medical and interventional therapy.Journal of Medical Case Reports (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 27, 2020 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

TGen appoints Dr. Sunil Sharma Physician-In-Chief
(The Translational Genomics Research Institute) TGen has announced the appointment of Sunil Sharma, M.D., F.A.C.P., M.B.A., as Physician-in-Chief. Dr. Sharma succeeds Daniel D. Von Hoff, M.D., F.A.C.P., a leading expert in pancreatic cancer, who was instrumental in developing key clinical and research programs at TGen. Dr. Von Hoff, who joined TGen in 2003, will continue as a Distinguished Professor and Executive Vice President, Molecular Medicine, to further his work in pancreatic cancer research and clinical trials. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 27, 2020 Category: Cancer & Oncology Source Type: news

New map of the immune landscape in pancreatic cancer could guide immunotherapy
(Michigan Medicine - University of Michigan) A new analysis highlights the diversity of immune response in pancreatic cancer, and points toward the need for treatments tailored to individual patients. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 26, 2020 Category: International Medicine & Public Health Source Type: news

Blood test may identify pancreatic cancers that will respond to treatment, researchers say
Researchers have developed a simple blood test to identify pancreatic cancers that are more likely to respond to treatment than others, according to a paper published Thursday by Clinical Cancer Research. (Source: Health News - UPI.com)
Source: Health News - UPI.com - October 22, 2020 Category: Consumer Health News Source Type: news

Pancreas Cells That Drive Type 1 Diabetes Appear in Healthy People, Too
Title: Pancreas Cells That Drive Type 1 Diabetes Appear in Healthy People, TooCategory: Health NewsCreated: 10/21/2020 12:00:00 AMLast Editorial Review: 10/22/2020 12:00:00 AM (Source: MedicineNet Diabetes General)
Source: MedicineNet Diabetes General - October 22, 2020 Category: Endocrinology Source Type: news

Type 1 diabetes: Tannic acid encapsulation protects transplanted islets from rejection
(University of Alabama at Birmingham) One therapy for Type 1 diabetes is promising -- transplanting pancreatic islets from cadavers -- but a need for immunosuppression and a reactivated autoimmunity lead to low graft viability and function after five years. Now researchers show that a protective coating of alternating layers of two biopolymers delays allograft and autoimmune-mediated rejection in mouse models of T1D. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - October 22, 2020 Category: Biology Source Type: news

New experimental blood test determines which pancreatic cancers will respond to treatment
(Van Andel Research Institute) Scientists have developed a simple, experimental blood test that distinguishes pancreatic cancers that respond to treatment from those that do not. This critical distinction could one day guide therapeutic decisions and spare patients with resistant cancers from undergoing unnecessary treatments with challenging side effects. The findings were published today inClinical Cancer Research, a journal of the American Association for Cancer Research. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 22, 2020 Category: Cancer & Oncology Source Type: news

Vaccine to treat and prevent lung, bowel and pancreatic cancer shows promise in the lab
(European Organisation for Research and Treatment of Cancer) An experimental vaccine, designed to enlist the body's own immune system to target cancer cells, has shown promise for treating and preventing cancer in mice. The vaccine was created to target a gene called KRAS that is involved in the development of many types of cancer, including lung, bowel and pancreatic cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 22, 2020 Category: Cancer & Oncology Source Type: news

Pancreas Cells That Drive Type 1 Diabetes Appear in Healthy People, Too
WEDNESDAY, Oct. 21, 2020 -- Scientists knew that dangerous T-cells lived in the pancreases of people with type 1 diabetes, but a new study shows they also take up residence in the pancreases of healthy individuals. Researchers from the La Jolla... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - October 21, 2020 Category: General Medicine Source Type: news

Salk's Dannielle Engle awarded over $1 million to study tobacco use on pancreatic cancer
(Salk Institute) Salk Institute Assistant Professor Dannielle Engle has been awarded a New Investigator Award from the Tobacco-Related Disease Research Program (TRDRP) to examine how tobacco use promotes cellular changes that lead to pancreatic cancer. Engle will receive over $1 million over three years to develop new models for examining how tobacco carcinogens (cancer-causing substances) lead to tumor development and metastasis. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 21, 2020 Category: Cancer & Oncology Source Type: news

Nature Communications publishes Bluestar Genomics' technology for cancer detection study
(EAG Advertising& Marketing) Bluestar Genomics, an innovative company leading the development of next-generation epigenomic approaches to early cancer detection, announced today the publication of study results in the peer-reviewed journalNature Communications. The study demonstrates the power of the company's platform to detect pancreatic cancer in its early stages, addressing the unmet need of more than 60,000 patients diagnosed with the disease each year in the United States alone. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 20, 2020 Category: International Medicine & Public Health Source Type: news

UEG: Pancreatic CA Down With Bariatric Sx for Obese With DM
Prevalence of pancreatic cancer higher in patients with predisposing diabetes and obesity without BS (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - October 16, 2020 Category: Cancer & Oncology Tags: Endocrinology, Family Medicine, Gastroenterology, Internal Medicine, Oncology, Surgery, Conference News, Source Type: news

UEG: Pancreatic CA Down With Bariatric Sx for Obese With DM
FRIDAY, Oct. 16, 2020 -- For patients with diabetes mellitus and obesity, bariatric surgery (BS) is associated with a reduced prevalence of pancreatic cancer compared with no BS, according to a study presented at UEG Week Virtual 2020, held Oct. 11... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 16, 2020 Category: Pharmaceuticals Source Type: news

What Is the Function of The Pancreas in The Body
? (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - October 16, 2020 Category: General Medicine Source Type: news

Pancreatic cancer: Subtypes with different aggressiveness discovered
(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) To date, no targeted personalized therapies for pancreatic cancer exist. Heidelberg Scientists have now succeeded for the first time in defining two differently aggressive molecular subtypes of pancreatic carcinoma. This provides new insights into the origin of the tumors. In the more aggressive group of tumors, a phenomenon known as 'viral mimicry' leads to a cancer-promoting inflammatory reaction. This could possibly be the basis for the development of a targeted, subtype-oriented therapy. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 15, 2020 Category: Cancer & Oncology Source Type: news

Microbiota-modulated CART+ enteric neurons autonomously regulate blood glucose
The gut microbiota affects tissue physiology, metabolism, and function of both the immune and nervous systems. We found that intrinsic enteric-associated neurons (iEANs) in mice are functionally adapted to the intestinal segment they occupy; ileal and colonic neurons are more responsive to microbial colonization than duodenal neurons. Specifically, a microbially responsive subset of viscerofugal CART+ neurons, enriched in the ileum and colon, modulated feeding and glucose metabolism. These CART+ neurons send axons to the prevertebral ganglia and are polysynaptically connected to the liver and pancreas. Microbiota depletion...
Source: ScienceNOW - October 15, 2020 Category: Science Authors: Muller, P. A., Matheis, F., Schneeberger, M., Kerner, Z., Jove, V., Mucida, D. Tags: Microbiology, Neuroscience r-articles Source Type: news

Weight-Loss Surgery May Cut Pancreatic Cancer Risk in People With Diabetes
Title: Weight-Loss Surgery May Cut Pancreatic Cancer Risk in People With DiabetesCategory: Health NewsCreated: 10/12/2020 12:00:00 AMLast Editorial Review: 10/13/2020 12:00:00 AM (Source: MedicineNet Diabetes General)
Source: MedicineNet Diabetes General - October 13, 2020 Category: Endocrinology Source Type: news

MR-Linac Radiation Therapy Promising in Pancreatic Cancer MR-Linac Radiation Therapy Promising in Pancreatic Cancer
Stereotactic magnetic resonance-guided adaptive radiation therapy delivered on an MR-Linac provided"encouraging" early local pancreatic cancer control with minimal severe treatment-related toxicity.Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - October 12, 2020 Category: Pathology Tags: Hematology-Oncology News Source Type: news

Weight-Loss Surgery May Cut Pancreatic Cancer Risk in People With Diabetes
MONDAY, Oct. 12, 2020 -- Weight-loss surgery significantly reduces the risk of pancreatic cancer in obese people with diabetes, a new study finds. For the study, the researchers analyzed 20 years of data from 1.4 million people, including more than... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - October 12, 2020 Category: General Medicine Source Type: news

Novel Dual-Hormone'Artificial Pancreas' Is Promising Novel Dual-Hormone'Artificial Pancreas' Is Promising
The fully automated dual hormone combination of rapid-acting insulin plus pramlintide, with no meal notification required, produced similar results to Fiasp-alone with meal signaling.Medscape Medical News (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - October 7, 2020 Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news

Yale cancer receives ACGT grant to advance strategies for treating pancreatic cancer
(Alliance for Cancer Gene Therapy) Alliance for Cancer Gene Therapy (ACGT) gives $500,000 research grant to Sidi Chen, Ph.D., with Yale School of Medicine and Yale Cancer Center to advance strategies for treating pancreatic cancer (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 6, 2020 Category: Cancer & Oncology Source Type: news

Pancreatic cancer: Does your urine and stools look like this? The hidden warning signs
PANCREATIC cancer is the fifth biggest cancer killer in England. What lies in the toilet could hold clues as to whether or not you have the disease. If your urine or stools are a certain colour it could be a major warning sign. (Source: Daily Express - Health)
Source: Daily Express - Health - October 5, 2020 Category: Consumer Health News Source Type: news

Pancreatic surgery: lower mortality with larger case volumes
(Institute for Quality and Efficiency in Health Care) Pancreatic surgery: lower mortality with larger case volumesThe survival probabilities are higher in hospitals where complex pancreatic surgery is performed more frequently. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 5, 2020 Category: International Medicine & Public Health Source Type: news

Regarding a successful treatment with artificial pancreas for a patient who attempted suicide using a high-dose insulin s.c. injection - Zhang JY, Shang T, Klonoff DC.
Dear Editor, We read with great interest an article published in Acute Medicine and Surgery by Toshihiro Sakurai et al. entitled "Successful treatment with artificial pancreas for a patient who attempted suicide using a high‐dose insulin s.c. injectio... (Source: SafetyLit)
Source: SafetyLit - October 3, 2020 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Pancreas Size, Shape Can Return to Normal in Diabetes Remission: Study
Title: Pancreas Size, Shape Can Return to Normal in Diabetes Remission: StudyCategory: Health NewsCreated: 9/30/2020 12:00:00 AMLast Editorial Review: 10/1/2020 12:00:00 AM (Source: MedicineNet Diabetes General)
Source: MedicineNet Diabetes General - October 1, 2020 Category: Endocrinology Source Type: news

Understanding beta cell growth may help treat diabetes
(Pennington Biomedical Research Center) New treatments for metabolic diseases, such as type 2 diabetes, could emerge from a study of how a single enzyme controls the growth of the pancreatic cells that produce insulin. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 1, 2020 Category: International Medicine & Public Health Source Type: news

Pancreas Size, Shape Can Return to Normal in Diabetes Remission: Study
WEDNESDAY, Sept. 30, 2020 -- Reversing type 2 diabetes can restore the pancreas to its normal size and shape, a new study finds. Previous research found that with remission of type 2 diabetes through significant weight loss, natural... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - September 30, 2020 Category: General Medicine Source Type: news

Pancreas Size, Shape Restored With Remission of T2DM
WEDNESDAY, Sept. 30, 2020 -- Pancreas size and shape can be restored with remission of type 2 diabetes, according to a study presented at the annual meeting of the European Association for the Study of Diabetes, held virtually from Sept. 21 to... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - September 30, 2020 Category: Pharmaceuticals Source Type: news

Single-cell RNA sequencing reveals details about individual cells in pancreatic tumors
(The Translational Genomics Research Institute) Led by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, and by HonorHealth Research and Innovation Institute, an international team of researchers have described in detail the individual cells that comprise the pancreatic cancer microenvironment, a critical step in devising new treatment options for patients with this aggressive and difficult-to-treat disease. The study results were published today in the scientific journal Genome Medicine, a publication of Springer Nature. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - September 30, 2020 Category: Biology Source Type: news

Oncotarget: A comprehensive analysis of clinical trials in pancreatic cancer
(Impact Journals LLC) The cover for issue 38 of Oncotarget features Figure 3, 'Summary of the time and cost for drug development (modified from DiMasi et al [2016],' by Katayama, et al. which reported that Pancreatic cancer is the most aggressive common cancer and is desperately in need of novel therapies. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 23, 2020 Category: International Medicine & Public Health Source Type: news

Researchers identify potential targets for deadliest form of pancreatic cancer
A team of researchers led by Mayo Clinic and the Translational Genomics Research Institute has identified specific potential therapeutic targets for the most aggressive and lethal form of pancreatic cancer. In what is believed to be the most comprehensive analysis of adenosquamous cancer of the pancreas (ASCP), the Mayo Clinic and Translational Genomics Research Institute [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - September 22, 2020 Category: Databases & Libraries Source Type: news

Back pain warning: It can be a sign of pancreatic cancer - how to tell
BACK pain can be attributed to a host of causes and it is not usually serious. In rare instances, it can be a sign of pancreatic cancer - here's how to tell. (Source: Daily Express - Health)
Source: Daily Express - Health - September 22, 2020 Category: Consumer Health News Source Type: news

Ginsburg died peacefully, unlike the tens of millions of babies whose violent murder she advocated
(Natural News) Just 45 days before the 2020 election, Ruth Bader Ginsburg, the first Jewish female justice of the Supreme Court, died from “complications of metastatic pancreas cancer,” triggering a wave of weeping and gnashing of teeth among leftists who worshiped her for supposedly being a “champion of justice.” But what about justice for the... (Source: NaturalNews.com)
Source: NaturalNews.com - September 21, 2020 Category: Consumer Health News Source Type: news

As nation mourns Ruth Bader Ginsburg, a look at advances in pancreatic cancer treatment
Ruth Bader Ginsburg, who served on the Supreme Court since 1993, died of pancreatic cancer Sept. 18.Ginsburg battled cancer several times throughout her life. She was treated for colon cancer in 1999, underwent surgery for pancreatic cancer in 2009 and had cancerous lesions removed from her lung in 2018. Ginsburg received chemotherapy for a recurrence of pancreatic cancer in 2019.Pancreatic cancer is the third leading cause of cancer-related death in the United States. A 6-inch-long gland in the abdomen, the pancreas makes digestive enzymes and hormones, such as insulin, that control blood sugar.No screening test exists fo...
Source: UCLA Newsroom: Health Sciences - September 21, 2020 Category: Universities & Medical Training Source Type: news

Pancreatic cancer symptoms: Can you feel that? First noticeable sign
PANCREATIC cancer symptoms are often non-specific and vague in the beginning. One of the first noticeable signs is associated with your stomach. (Source: Daily Express - Health)
Source: Daily Express - Health - September 21, 2020 Category: Consumer Health News Source Type: news

Pancreatic cancer symptoms: The first ‘noticeable’ sign in the stomach area
PANCREATIC cancer symptoms are often non-specific and vague in the beginning. One of the first noticeable signs is associated with your stomach. (Source: Daily Express - Health)
Source: Daily Express - Health - September 21, 2020 Category: Consumer Health News Source Type: news

Ruth Bader Ginsburg Dies From Pancreatic Cancer Ruth Bader Ginsburg Dies From Pancreatic Cancer
The 87-year-old diminutive but fiery jurist was a three-time cancer survivor and became the second woman to serve on the US Supreme Court when President Bill Clinton appointed her in 1993.WebMD Health News (Source: Medscape Business of Medicine Headlines)
Source: Medscape Business of Medicine Headlines - September 19, 2020 Category: Pharmaceuticals Tags: Family Medicine/Primary Care News Alert Source Type: news

Ruth Bader Ginsburg Dies from Pancreatic Cancer
The three-time cancer survivor faced her most recent troubles in late 2018, when she had surgery for lung cancer that was discovered after she broke several ribs in a fall in her chambers. In January of 2020, Ginsburg announced that she was cancer free. But in July she said she was undergoing chemotherapy after a lesion was found on her liver. (Source: WebMD Health)
Source: WebMD Health - September 19, 2020 Category: Consumer Health News Source Type: news

How Cancer Shaped Justice Ruth Bader Ginsburg ’s Life and Work
The name Ruth Bader Ginsburg became almost synonymous with strength and stamina as she rose to prominence in judicial and feminist circles throughout her long career. Famously nicknamed the Notorious RBG and known for her grueling fitness regimen, the late Supreme Court justice also struggled with cancer and other health issues for the better part of her time on the bench — culminating with her death on Sept. 18 at the age of 87 of complications from metastatic pancreatic cancer. Ginsburg’s health issues became public in 1999, six years after her appointment to the Supreme Court, when she had surgery for early-...
Source: TIME: Health - September 19, 2020 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized Cancer healthytime remembrance Source Type: news

Infanticide advocate Ruth Bader Ginsburg dies from pancreatic cancer, after decades of promoting abortions and medical violence against children
(Natural News) Supreme Court Justice and infanticide advocate Ruth Bader Ginsburg died today at age 87, passing away “peacefully” even though over 60 million human babies have been violently murdered in America due to abortion policies that Ginsburg helped advocate across this nation. Ginsburg refused to grant millions of children their own right to die... (Source: NaturalNews.com)
Source: NaturalNews.com - September 18, 2020 Category: Consumer Health News Source Type: news

Supreme Court Justice Ruth Bader Ginsburg Dies at 87
FRIDAY, Sept. 18, 2020 -- U.S. Supreme Court Justice Ruth Bader Ginsburg died on Friday, the court announced. The cause was complications from pancreatic cancer. Ginsburg was 87. First appointed to the court in 1993 by President Bill Clinton,... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - September 18, 2020 Category: General Medicine Source Type: news

A ferry protein in the pancreas protects it from the stress induced by a high-fat diet
(Tokyo Institute of Technology) Scientists at Tokyo Institute of Technology (Tokyo Tech) have now uncovered a key mechanism by which pancreatic function is maintained in response to a high-fat diet. A protein present in pancreatic insulin-producing cells protects them from damage under the stress induced by a high-fat diet. As the world increases its intake of high-fat foods and as type 2 diabetes incidence rises as a result, this protein could be a novel therapeutic target for type 2 diabetes mellitus. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - September 16, 2020 Category: Biology Source Type: news

Artificial pancreas helps children with type 1 diabetes
A new artificial pancreas system, which monitors and regulates blood glucose levels, proved safe and effective in young children with type 1 diabetes. (Source: NIH Research Matters from the National Institutes of Health (NIH))
Source: NIH Research Matters from the National Institutes of Health (NIH) - September 14, 2020 Category: Consumer Health News Source Type: news

Mayo Clinic and TGen ID potential targets for the most-deadly form of pancreatic cancer
(The Translational Genomics Research Institute) In what is believed to be the most comprehensive analysis of adenosquamous cancer of the pancreas (ASCP), the Mayo Clinic and TGen team identified, in preclinical models, therapeutic targets for this extremely fast-moving and deadly form of pancreatic cancer, and identified already available cancer inhibitors originally designed for other types of cancer, according to a study published today in the journal Cancer Research. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 14, 2020 Category: International Medicine & Public Health Source Type: news

Pancreatic cancer symptoms: Have you smelt this when going to the toilet? Warning sign
PANCREATIC cancer survival outcomes depend on the stage of the cancer so it is imperative to act on the warning signs when they appear. One sign is associated with a particular smell - what is it? (Source: Daily Express - Health)
Source: Daily Express - Health - September 11, 2020 Category: Consumer Health News Source Type: news

Cancer Projects to Diversify Genetic Research Receive New Grants
Because much cancer research and clinical trials have been based on white populations, efforts to explore the ways race and ethnicity influence disease are underway. (Source: NYT Health)
Source: NYT Health - September 11, 2020 Category: Consumer Health News Authors: Emma Goldberg Tags: Race and Ethnicity Colon and Colorectal Cancer Pancreatic Cancer Bladder Cancer Breast Cancer Black People Genetics and Heredity Cold Spring Harbor Laboratory Dana-Farber Cancer Institute Memorial Sloan-Kettering Cancer Center Mount Si Source Type: news

Epigenetic changes precede onset of diabetes
(Deutsches Zentrum fuer Diabetesforschung DZD) Epigenetic* changes in the islets of Langerhans of the pancreas can be detected in patients several years before the diagnosis of type 2 diabetes. These changes are responsible for the altered methylation activity of specific genes which differs from that in healthy individuals. In humans, 105 such changes have been discovered in blood cells. This was shown in a study by researchers from the DZD/DIfE, which has now been published in the journal Diabetes. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 10, 2020 Category: International Medicine & Public Health Source Type: news