From Patent To Product: The Speed Of The Digital Health Evolution
We’re bombarded with mindblowing headlines of new medical miracles every day. BCI helps paralysed patients talk again! Robots in the stomach! Micro-organs on organ-on-chip technologies! But it is almost impossible to see through the hype and know if and when these will yield actual, patient-ready solutions. So let’s get into this maze and decipher how a new, revolutionary medical technology develops from an ingenious idea to a market-ready product with two real-life examples: the artificial pancreas and wireless ECG.
In early April, the UK’s NHS rolled out an artificial pancreas (APS) for Type 1 diabetes patients,...
Source: The Medical Futurist - April 16, 2024 Category: Information Technology Authors: Andrea Koncz Tags: TMF artificial intelligence digital health Innovation patent analysis Medicine Source Type: blogs
Fight Aging! Newsletter, April 15th 2024
In conclusion, although several clinical trials targeting SnCs are ongoing, various questions about the biology of SnCs remain open, resulting in a gap between molecular and cellular data. Concerning the need, initiatives such as SenNet aiming to create openly accessible atlases of SnCs should contribute enormously to the area. Advances in understanding the subcellular structure, the heterogeneity, and the dynamics of SnCs require the integration of molecular and cellular techniques with data analysis packages to evaluate high throughput evidence from microscopy and flow cytometry. It is also necessary to develop new equip...
Source: Fight Aging! - April 14, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Long-Lived RNA that is Never Replaced in Neurons
The question of whether there are long-lived molecules in long-lived neurons in the brain is an interesting one. Are there specific molecules in the brain that never get replaced across a lifetime, and thus might be vulnerable to damage in the form of modifications that disrupt function? This remains a somewhat hypothetical concern, in the sense that there is no direct demonstration that this is a significant source of dysfunction in late life. Researchers have found evidence for long-lived nuclear pore proteins, however, and here another group presents evidence for long-lived RNA molecules.
Most cells in the huma...
Source: Fight Aging! - April 12, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
LyGenesis Commences Phase II Trial for Growth of Liver Organoids in Patient Lymph Nodes
LyGenesis has been working towards liver organoid transplantation as a treatment for liver failure for some years now. Organs such as the liver, thymus, and a few others do not need to be in any specific place in the body to carry out many of their varied functions. Some of the vital work of the liver, for example, can be conducted in small organoids grown from liver cells transplanted into lymph nodes or other parts of the body that can act as stable bioreactors.
Even setting aside the possibility of growing functional liver organoids from patient cells or universal cell lines, it is worth noting that the old appro...
Source: Fight Aging! - April 9, 2024 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Fight Aging! Newsletter, April 8th 2024
In this study, we tested a stem cell secretome product, which contains extracellular vesicles and growth factors, cytoskeletal remodeling factors, and immunomodulatory factors. We examined the effects of 4 weeks of 2×/week unilateral intramuscular secretome injections (quadriceps) in ambulatory aged male C57BL/6 mice (22-24 months) compared to saline-injected aged-matched controls.
Secretome delivery substantially increased whole-body lean mass and decreased fat mass, corresponding to higher myofiber cross-sectional area and smaller adipocyte size, respectively. Secretome-treated mice also had greater whole-bod...
Source: Fight Aging! - April 7, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Raised Inflammatory Markers Somewhat Correlate with Incidence of Age-Related Disease
Onset, progression, and resolution of inflammation are all driven by the interaction of many different complex signaling processes. The immune system as a whole is highly complex, an array of many different interacting populations of specialized cells. Nonetheless, there are a few individual circulating signal proteins that, to some degree at least, tend to reflect overall inflammatory status. Not reliably, but enough to produce correlations in patient populations of any reasonable size.
Today's open access paper is a survey of the literature on inflammatory cytokines IL-6, TNF, and IL-1β, pulling reported measures...
Source: Fight Aging! - April 3, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Interview with Stefany Shaheen: Revolutionizing diabetes care through cell therapies
I had the extraordinary opportunity to chat with Stefany Shaheen, the Chief Strategy Officer of Advanced Regenerative Manufacturing Institute (ARMI) and BioFab USA, about the transformative potential of cell therapies for individuals living with diabetes. Stefany shared her remarkable journey, insights on cell therapies’ current status, approval challenges, and how the diabetes community can contribute to advancing research in this field.
A few months before this discussion with Stefany, I had the opportunity to hear Dean Kamen speak at the recent ...
Source: Scott's Diabetes Blog - April 1, 2024 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs
Palliative and hospice care in hospitals and clinics: the good, the bad, and the ugly
I walk into the patient’s hospital room during evening rounds. He looks pale and tired, having recently completed a round of chemotherapy for his stage IV pancreatic cancer. His wife is at the bedside, scared and concerned about her husband’s rapid decline. I sit down to discuss goals of care when the patient immediately says,
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Palliative and hospice care in hospitals and clinics: the good, the bad, and the ugly originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 1, 2024 Category: General Medicine Authors: Earl Stewart, Jr., MD & America ’s nurses have PTSD: Will anyone listen to them?
My first clinical rotation as a nursing student was on the same floor where my mother died of cancer. And my very first patient was a young Hispanic man with four children. I was asked to tell him that he had pancreatic cancer and very little time left. I was 21 years old and the
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America’s nurses have PTSD: Will anyone listen to them? originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 9, 2024 Category: General Medicine Authors: Tara Rynders, RN Tags: Conditions Nursing Psychiatry Source Type: blogs
Fight Aging! Newsletter, March 4th 2024
In conclusion, HSV (but not CMV) infection may be indicative of doubled dementia risk.
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Increased Dietary Leucine Activates mTOR Signaling in Macrophages, Accelerating Atherosclerosis
https://www.fightaging.org/archives/2024/02/increased-dietary-leucine-activates-mtor-signaling-in-macrophages-accelerating-atherosclerosis/
Leucine is an essential amino acid, only obtained from the diet rather than synthesized by our cells. Leucine supplementation has been proposed as a way to slow the loss of muscle mass with age, as leucine processing becomes dysregulated with aging in a way...
Source: Fight Aging! - March 3, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Aged Pancreatic Fibroblasts Secrete GDF-15, Encouraging Tumor Growth
Researchers here note one of a broad range of examples in which age-related changes in the state and behavior of non-cancerous cells results in a more hospitable environment for the growth of neighboring cancerous tissue. Cancer is an age-related condition not just because of increased damage to cells in older tissues, nor just because the immune system falters in its surveillance of potentially cancerous cells, but also due to other maladaptive changes that favor the metabolism and growth of some forms of cancerous cells.
A new study provides clues as to why pancreatic cancer is more common and aggressive in olde...
Source: Fight Aging! - February 28, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Patient Advocates Argue Exercising Bayh-Dole " March-In " Rights Reasonable to Ensure Ongoing Supply of an Insulin Novo Nordisk Intends to Discontinue
Back in 2016 (when President Obama was still in office), the trade group known as the Pharmaceutical Research and Manufacturers of America (better known by the acronym PhRMA) claimed in an organization-published white paper (seehttps://web.archive.org/web/20161022175500/https://phrma.org/sites/default/files/pdf/bayh-dole-act-white-paper-summary.pdf for an archived copy of that paper from PhRMA; note that it has since been removed from PhRMA ' s website, hence I found a copy on the Internet Archive) that championed the Bayh-Dole Act of 1980. Understand that what PhRMA really wants to prevent a particular provision...
Source: Scott's Web Log - February 11, 2024 Category: Endocrinology Tags: march-in rights 2024 Alliance to Protect Insulin Choice APIC Bayh-Dole insulin detemir Levemir Novo Nordisk Source Type: blogs
The 6 Most Exciting Medical Technology Breakthroughs Of Recent Years
Amidst the flurry of hyped technologies, it’s not easy to pinpoint which specific technological breakthroughs will have the most impact in the coming years.
Dr. Meskó, The Medical Futurist, reviews multiple reports, studies, and articles daily. Consequently, our days are filled with awe-inspiring developments. However, our aim here is to offer more than just a compilation of “wow, look how fascinating” stories.
To achieve this, we have selected technologies that:
Have undergone significant breakthroughs in recent years, be it in regulatory, technological, or scientific aspects
Are anticipate...
Source: The Medical Futurist - January 9, 2024 Category: Information Technology Authors: Andrea Koncz Tags: TMF artificial intelligence digital health future Healthcare Source Type: blogs
How Can the Immune System Go Awry?
This post is part of a miniseries on the immune system. Be sure to check out the other posts in this series that you may have missed.
The immune system is designed to closely monitor the body for signs of intruders that may cause infection. But what happens if it malfunctions? Overactive and underactive immune systems can both have negative effects on your health.
Autoimmune Disorders
To effectively monitor the body for pathogens, the adaptive immune system has to learn what a pathogen “looks like” on a molecular level. During their development, white blood cells go through training to learn how to differe...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 8, 2024 Category: Research Authors: Chrissa Chverchko Tags: Cells Injury and Illness Diseases Immunology Miniseries Infectious Diseases Microbes Sepsis Source Type: blogs
Deconstructing diabetes stigma: A panel discussion
In conclusion, the discussion was an enriching and eye-opening event, bringing together passionate individuals dedicated to challenging the stigma around diabetes. By amplifying our voices and working together, we can make a lasting impact on the lives of those touched by diabetes.Visit enddiabetesstigma.org and become a part of the movement for change. If you’d like to get involved in spreading more awareness about this, reach out to Dennis and/or leave a comment here.
Full transcript and show notes
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Source: Scott's Diabetes Blog - January 4, 2024 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs
