In Regard to Parikh et al.
We found the phase 2 trial by Parikh et al1 on ablative, 5-fraction, stereotactic magnetic resonance –guided, on-table adaptive radiation therapy (MRgRT-SMART) intriguing. Although we acknowledge MRgRT-SMART's promise, we emphasize the need for caution in suggesting its effect on disease management unless robust evidence is provided. Despite the authors not positioning MRgRT-SMART as the primary reference technology for pancreatic cancer, there may be an overemphasis on the widespread interpretation of this evidence. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 15, 2024 Category: Radiology Authors: Francesco Cellini, Michele Fiore Tags: Letters to the Editor Source Type: research
Management of Multiple Ducts at the Transected Pancreatic Neck in a Whipple Procedure
Am Surg. 2024 Apr 14:31348241246177. doi: 10.1177/00031348241246177. Online ahead of print.NO ABSTRACTPMID:38616621 | DOI:10.1177/00031348241246177 (Source: The American Surgeon)
Source: The American Surgeon - April 15, 2024 Category: Surgery Authors: Mohamed Abdelgawad Diana Wu Omar Kamel Sally Abdelgawad Hishaam Ismael Source Type: research
Advancements in medical treatment for pancreatic neuroendocrine tumors: A beacon of hope
World J Gastroenterol. 2024 Mar 28;30(12):1670-1675. doi: 10.3748/wjg.v30.i12.1670.ABSTRACTThis editorial highlights the remarkable advancements in medical treatment strategies for pancreatic neuroendocrine tumors (pan-NETs), emphasizing tailored approaches for specific subtypes. Cytoreductive surgery and somatostatin analogs (SSAs) play pivotal roles in managing tumors, while palliative options such as molecular targeted therapy, peptide receptor radionuclide therapy, and chemotherapy are reserved for SSA-refractory patients. Gastrinomas, insulinomas, glucagonomas, carcinoid tumors and VIPomas necessitate distinct thera-p...
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Somdatta Giri Jayaprakash Sahoo Source Type: research
< em > ALKBH5 < /em > suppresses autophagic flux < em > via < /em > N6-methyladenosine demethylation of < em > ZKSCAN3 < /em > mRNA in acute pancreatitis
CONCLUSION: ALKBH5 inhibits autophagic flux through m6A demethylation of ZKSCAN3 mRNA in AP, thereby aggravating the severity of the disease.PMID:38617741 | PMC:PMC11008368 | DOI:10.3748/wjg.v30.i12.1764 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Tao Zhang Shuai Zhu Geng-Wen Huang Source Type: research
Treatment patterns and survival outcomes in patients with non-metastatic early-onset pancreatic cancer
CONCLUSION: AT improves postoperative survival in localized patients. Surgery after NAT and RCT are the preferred therapeutic options for patients with locally advanced EOPC.PMID:38617739 | PMC:PMC11008379 | DOI:10.3748/wjg.v30.i12.1739 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Le-Tian Zhang Ying Zhang Bi-Yang Cao Chen-Chen Wu Jing Wang Source Type: research
Innovative pathways allow safe discharge of mild acute pancreatitis from the emergency room
World J Gastroenterol. 2024 Mar 21;30(11):1475-1479. doi: 10.3748/wjg.v30.i11.1475.ABSTRACTAcute pancreatitis (AP) is a leading cause of gastrointestinal-related hospitalizations in the United States, resulting in 300000 admissions per year with an estimated cost of over $2.6 billion annually. The severity of AP is determined by the presence of pancreatic complications and end-organ damage. While moderate/severe pancreatitis can be associated with significant morbidity and mortality, the majority of patients have a mild presentation with an uncomplicated course and mortality rate of less than 2%. Despite favorable outcomes...
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Darshan J Kothari Sunil G Sheth Source Type: research
< em > ALKBH5 < /em > suppresses autophagic flux < em > via < /em > N6-methyladenosine demethylation of < em > ZKSCAN3 < /em > mRNA in acute pancreatitis
CONCLUSION: ALKBH5 inhibits autophagic flux through m6A demethylation of ZKSCAN3 mRNA in AP, thereby aggravating the severity of the disease.PMID:38617741 | PMC:PMC11008368 | DOI:10.3748/wjg.v30.i12.1764 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Tao Zhang Shuai Zhu Geng-Wen Huang Source Type: research
Treatment patterns and survival outcomes in patients with non-metastatic early-onset pancreatic cancer
CONCLUSION: AT improves postoperative survival in localized patients. Surgery after NAT and RCT are the preferred therapeutic options for patients with locally advanced EOPC.PMID:38617739 | PMC:PMC11008379 | DOI:10.3748/wjg.v30.i12.1739 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Le-Tian Zhang Ying Zhang Bi-Yang Cao Chen-Chen Wu Jing Wang Source Type: research
Innovative pathways allow safe discharge of mild acute pancreatitis from the emergency room
World J Gastroenterol. 2024 Mar 21;30(11):1475-1479. doi: 10.3748/wjg.v30.i11.1475.ABSTRACTAcute pancreatitis (AP) is a leading cause of gastrointestinal-related hospitalizations in the United States, resulting in 300000 admissions per year with an estimated cost of over $2.6 billion annually. The severity of AP is determined by the presence of pancreatic complications and end-organ damage. While moderate/severe pancreatitis can be associated with significant morbidity and mortality, the majority of patients have a mild presentation with an uncomplicated course and mortality rate of less than 2%. Despite favorable outcomes...
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Darshan J Kothari Sunil G Sheth Source Type: research
Advancements in medical treatment for pancreatic neuroendocrine tumors: A beacon of hope
World J Gastroenterol. 2024 Mar 28;30(12):1670-1675. doi: 10.3748/wjg.v30.i12.1670.ABSTRACTThis editorial highlights the remarkable advancements in medical treatment strategies for pancreatic neuroendocrine tumors (pan-NETs), emphasizing tailored approaches for specific subtypes. Cytoreductive surgery and somatostatin analogs (SSAs) play pivotal roles in managing tumors, while palliative options such as molecular targeted therapy, peptide receptor radionuclide therapy, and chemotherapy are reserved for SSA-refractory patients. Gastrinomas, insulinomas, glucagonomas, carcinoid tumors and VIPomas necessitate distinct thera-p...
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Somdatta Giri Jayaprakash Sahoo Source Type: research
Invited commentary for “Meta-analysis of adjuvant chemotherapy versus no adjuvant chemotherapy for resected stage I pancreatic cancer
Evans et al performed a meta-analysis of 6 observational studies published over a 5-year period ending in 2022 in an attempt to capture associations between adjuvant systemic chemotherapy and overall survival for nearly 7,000 patients with stage IA and IB pancreatic ductal adenocarcinoma who underwent cura tive-intent resection. Using proper statistical analysis with Preferred Reporting Items for Systematic Reviews and Meta-Analyses standards and Risk Of Bias In Non-randomised Studies - of Interventions assessment tools for bias, the authors demonstrated that the use of adjuvant systemic chemotherapy was associated with ...
Source: Surgery - April 15, 2024 Category: Surgery Authors: Michael G. House Source Type: research
CD200 is overexpressed in the pancreatic tumor microenvironment and predictive of overall survival
This study highlights the importance of CD200 expression in pancreatic cancer and provides the rationale for designing novel therapeutic strategies that target this protein. (Source: Cancer Immunology, Immunotherapy)
Source: Cancer Immunology, Immunotherapy - April 15, 2024 Category: Cancer & Oncology Source Type: research
Aspects and outcomes of surveillance for individuals at high-risk of pancreatic cancer
AbstractPancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related deaths and is associated with a poor prognosis. The majority of these cancers are detected at a late stage, contributing to the bad prognosis. This underscores the need for novel, enhanced early detection strategies to improve the outcomes. While population-based screening is not recommended due to the relatively low incidence of PDAC, surveillance is recommended for individuals at high risk for PDAC due to their increased incidence of the disease. However, the outcomes of pancreatic cancer surveillance in high-risk individuals are not sor...
Source: Familial Cancer - April 15, 2024 Category: Cancer & Oncology Source Type: research
Establishment, characterization, and biobanking of 36 pancreatic cancer organoids: prediction of metastasis in resectable pancreatic cancer
ConclusionsThese data suggest that the presence of metastatic PDAC can be identified by integrating molecular compositions and drug responses of borderline resectable PDAC. (Source: Cellular Oncology)
Source: Cellular Oncology - April 15, 2024 Category: Cancer & Oncology Source Type: research
Stromal rigidity stress accelerates pancreatic intraepithelial neoplasia progression and chromosomal instability via nuclear PTK2 localization
Since the mechanotransduction by stromal stiffness stimulates the rupture and repair of the nuclear envelope in pancreatic progenitor cells, accumulated genomic aberrations are under selection in the tumor microenvironment. Analysis of cell growth, micronuclei, and γH2AX foci links to mechanotransduction pressure in vivo during serial orthotopic passages of mouse KrasLSL-G12D/+;Trp53flox/flox;Pdx1-Cre (KPC) cancer cells in the tumor and in migrating through the size-restricted 3μm micropores. To search for pancreatic cancer cell-of-origin, analysis of single -cell datasets revealed that the ECM shapes an alternate route ...
Source: American Journal of Pathology - April 15, 2024 Category: Pathology Authors: Li-Yun Ding, Chia-Jung Chang, Szu-Ying Chen, Kuan-Lin Chen, Yueh-Shan Li, Yun-Chieh Wu, Ting-Yi Hsu, Hsin-Yu Ying, Hsin-Yi Wu, Michael, W. Hughes, Chia-Yih Wang, Chih-Han Chang, Ming-Jer Tang, Woei-Jer Chuang, Yan-Shen Shan, Chia-Jung Chang, Po-Hsien Huan Tags: Regular Article Source Type: research
