Long non-coding RNA LOXL1-AS1: a potential biomarker and therapeutic target in human malignant tumors
This article reviews the current understanding of the biological function and clinical significance of LOXL1-AS1 in human cancers. These findings suggest that LOXL1-AS1 may be both a reliable biomarker and a potential therapeutic target for cancers.PMID:38693424 | DOI:10.1007/s10238-024-01355-7 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Xiao-Ping Fu Chun-Yan Ji Wen-Qian Tang Ting-Ting Yu Lei Luo Source Type: research
Molecular targets and mechanisms of different aberrant alternative splicing in metastatic liver cancer
World J Clin Oncol. 2024 Apr 24;15(4):531-539. doi: 10.5306/wjco.v15.i4.531.ABSTRACTMetastasis remains a major challenge in the successful management of malignant diseases. The liver is a major site of metastatic disease and a leading cause of death from gastrointestinal malignancies such as colon, stomach, and pancreatic cancers, as well as melanoma, breast cancer, and sarcoma. As an important factor that influences the development of metastatic liver cancer, alternative splicing drives the diversity of RNA transcripts and protein subtypes, which may provide potential to broaden the target space. In particular, the dysfun...
Source: Clinical Genitourinary Cancer - May 1, 2024 Category: Cancer & Oncology Authors: De-Yi Geng Qing-Shan Chen Wan-Xian Chen Lin-Sa Zhou Xiao-Sha Han Qi-Hu Xie Geng-Hong Guo Xue-Fen Chen Jia-Sheng Chen Xiao-Ping Zhong Source Type: research
Long non-coding RNA LOXL1-AS1: a potential biomarker and therapeutic target in human malignant tumors
This article reviews the current understanding of the biological function and clinical significance of LOXL1-AS1 in human cancers. These findings suggest that LOXL1-AS1 may be both a reliable biomarker and a potential therapeutic target for cancers.PMID:38693424 | DOI:10.1007/s10238-024-01355-7 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Xiao-Ping Fu Chun-Yan Ji Wen-Qian Tang Ting-Ting Yu Lei Luo Source Type: research
Correction: Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/ GPX4 expression
J Exp Clin Cancer Res. 2024 May 2;43(1):131. doi: 10.1186/s13046-024-03051-6.NO ABSTRACTPMID:38693552 | DOI:10.1186/s13046-024-03051-6 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Yaya Qiao Meng Su Huifang Zhao Huanle Liu Chenxi Wang Xintong Dai Lingling Liu Guangju Liu Huanran Sun Mingming Sun Jiyan Wang Zhen Li Jun Fan Quan Zhang Chunshen Li Fangmin Situ Jun Xue Zhenghu Jia Chunze Zhang Shuai Zhang Changliang Shan Source Type: research
NIR-II light in clinical oncology: opportunities and challenges
Nat Rev Clin Oncol. 2024 May 1. doi: 10.1038/s41571-024-00892-0. Online ahead of print.ABSTRACTNovel strategies utilizing light in the second near-infrared region (NIR-II; 900-1,880 nm wavelengths) offer the potential to visualize and treat solid tumours with enhanced precision. Over the past few decades, numerous techniques leveraging NIR-II light have been developed with the aim of precisely eliminating tumours while maximally preserving organ function. During cancer surgery, NIR-II optical imaging enables the visualization of clinically occult lesions and surrounding vital structures with increased sensitivity and resol...
Source: Clinical Colorectal Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Zeyu Zhang Yang Du Xiaojing Shi Kun Wang Qiaojun Qu Qian Liang Xiaopeng Ma Kunshan He Chongwei Chi Jianqiang Tang Bo Liu Jiafu Ji Jun Wang Jiahong Dong Zhenhua Hu Jie Tian Source Type: research
Elevated cardiovascular risk and acute events in hospitalized colon cancer survivors: A decade-apart study of two nationwide cohorts
CONCLUSION: Colon cancer survivors hospitalized 10 years apart in the United States showed an increased CVD risk with an increased risk of acute cardiovascular events (stroke 28%, PE 47%, arrhythmia 41%, and cardiac arrest 63%). It is vital to regularly screen colon cancer survivors with concomitant CVD risk factors to curtail long-term cardiovascular complications.PMID:38689632 | PMC:PMC11056864 | DOI:10.5306/wjco.v15.i4.548 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Rupak Desai Avilash Mondal Vivek Patel Sandeep Singh Shaylika Chauhan Akhil Jain Source Type: research
Comparative effectiveness of immunotherapy and chemotherapy in patients with metastatic colorectal cancer stratified by microsatellite instability status
CONCLUSION: In this population-based study using the NCDB, immunotherapy treatment was associated with significantly improved OS compared to chemotherapy in patients with MSI-H metastatic colorectal cancer, but not in those with MSI-L/MSS metastatic colorectal cancer. Further studies are warranted to determine the optimal therapeutic approach for patients with MSI-L/MSS metastatic colorectal cancer.PMID:38689622 | PMC:PMC11056865 | DOI:10.5306/wjco.v15.i4.540 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Chen-Gu Niu Jing Zhang Aniket-Vijay Rao Utsav Joshi Patrick Okolo Source Type: research
Britanin - a beacon of hope against gastrointestinal tumors?
World J Clin Oncol. 2024 Apr 24;15(4):523-530. doi: 10.5306/wjco.v15.i4.523.ABSTRACTBritanin is a bioactive sesquiterpene lactone known for its potent anti-inflammatory and anti-oxidant properties. It also exhibits significant anti-tumor activity, suppressing tumor growth in vitro and in vivo. The current body of research on Britanin includes thirty papers predominantly related to neoplasms, the majority of which are gastrointestinal tumors that have not been summarized before. To drive academic debate, the present paper reviews the available research on Britanin in gastrointestinal tumors. It also outlines novel research ...
Source: Clinical Colorectal Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Agnieszka Kajdanek Damian Ko łat Lin-Yong Zhao Mateusz Kciuk Zbigniew Pasieka Żaneta Kałuzińska-Kołat Source Type: research
MAPKAP1 orchestrates macrophage polarization and lipid metabolism in fatty liver-enhanced colorectal cancer
This study explores the mechanistic role of fatty liver in CRC progression, focusing on macrophage polarization and lipid metabolism. A murine fatty liver model was created with a high-fat diet (HFD), and CRC was induced using AOM and DSS. Single-cell transcriptome sequencing (scRNA-seq) identified MAPKAP1 as a critical gene promoting CRC via M2 macrophage polarization and lipid metabolism reprogramming. Prognosis analysis on the TCGA-CRC dataset confirmed MAPKAP1's significance. In vitro and in vivo experiments demonstrated that EVs from fatty liver cells enhanced MAPKAP1 expression, accelerating CRC development and metas...
Source: Translational Oncology - May 1, 2024 Category: Cancer & Oncology Authors: Bo Huang Zhenqiu Yu Dejun Cui Fawang Du Source Type: research
Disproportionate neuroanatomical effects of < em > DCC < /em > haploinsufficiency in adolescence compared with adulthood: links to dopamine, connectivity, covariance, and gene expression brain maps in mice
CONCLUSION: The neuroanatomical phenotype of DCC haploinsufficiency described in mice parallels that observed in DCC-haploinsufficient humans. It is critical to understand the DCC-haploinsufficient mouse as a clinically relevant model system.PMID:38692693 | DOI:10.1503/jpn.230106 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - May 1, 2024 Category: Psychiatry Authors: Daniel Hoops Yohan Yee Christopher Hammill Sammi Wong Colleen Manitt Barry J Bedell Lindsay Cahill Jason P Lerch Cecilia Flores John G Sled Source Type: research
Disproportionate neuroanatomical effects of < em > DCC < /em > haploinsufficiency in adolescence compared with adulthood: links to dopamine, connectivity, covariance, and gene expression brain maps in mice
CONCLUSION: The neuroanatomical phenotype of DCC haploinsufficiency described in mice parallels that observed in DCC-haploinsufficient humans. It is critical to understand the DCC-haploinsufficient mouse as a clinically relevant model system.PMID:38692693 | DOI:10.1503/jpn.230106 (Source: J Psychiatry Neurosc...)
Source: J Psychiatry Neurosc... - May 1, 2024 Category: Psychiatry Authors: Daniel Hoops Yohan Yee Christopher Hammill Sammi Wong Colleen Manitt Barry J Bedell Lindsay Cahill Jason P Lerch Cecilia Flores John G Sled Source Type: research
Research on the Effect and Mechanism of Selenium on Colorectal Cancer Through TRIM32
In conclusion, our findings provided evidence that Se inhibited the growth of colorectal cancer cells by down-regulating TRIM32.PMID:38691306 | DOI:10.1007/s12011-024-04206-4 (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - May 1, 2024 Category: Biology Authors: Xiaohua Cai Yintong Su Jiayu Ning Xingxing Fan Mei Shen Source Type: research
Zinc Suppresses Colorectal Cancer Development through Cell-mediated Immunity
Yakugaku Zasshi. 2024;144(5):475-481. doi: 10.1248/yakushi.23-00154-1.ABSTRACTZinc is one of the essential trace elements, and is involved in various functions in the body. Zinc deficiency is known to cause immune abnormalities, but the mechanism is not fully understood. Therefore, we focused our research on tumor immunity to elucidate the effect of zinc on colorectal cancer and its mechanisms. Mice were treated with azoxymethane (AOM) and dextran sodium sulfate (DSS) to develop colorectal cancer, then the relationship between zinc content in the diet and the number and area of tumors in the colon was observed. The number ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Keigo Nishida Naoya Nakagawa Source Type: research
Effect of Orem's self-care model on discharge readiness of patients undergoing enterostomy: A randomized controlled trial
CONCLUSIONS: The designed discharge readiness program based on Orem's self-care could promote effective patient discharge readiness, self-care knowledge, self-care skills, and QoL.TRIAL REGISTRATION: The trial number ChiCTR2200056302 registered on ClinicalTrials.gov.PMID:38692158 | DOI:10.1016/j.ejon.2024.102549 (Source: European Journal of Oncology Nursing)
Source: European Journal of Oncology Nursing - May 1, 2024 Category: Nursing Authors: Si-Qing Li Cui-Lian Luo Hong Qiu Yu-Xia Liu Jian-Min Chen Source Type: research
Long non-coding RNA LOXL1-AS1: a potential biomarker and therapeutic target in human malignant tumors
This article reviews the current understanding of the biological function and clinical significance of LOXL1-AS1 in human cancers. These findings suggest that LOXL1-AS1 may be both a reliable biomarker and a potential therapeutic target for cancers.PMID:38693424 | DOI:10.1007/s10238-024-01355-7 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Xiao-Ping Fu Chun-Yan Ji Wen-Qian Tang Ting-Ting Yu Lei Luo Source Type: research
