Functionalized liposomes as a potential drug delivery systems for colon cancer treatment: A systematic review
Int J Biol Macromol. 2024 Apr 30:132023. doi: 10.1016/j.ijbiomac.2024.132023. Online ahead of print.ABSTRACTColon cancer is one of the lethal diseases in the world with approximately 700,000 fatalities annually (Abdulzehra et al., 2023 [1]). Nowadays, due to the side effects of existing methods in the treatment of colon cancer such as radiotherapy and chemotherapy, the use of targeted nanocarriers in cancer treatment has received wide attention, and among them, especially liposomes have been studied a lot. Based on this, anti-tumor drugs hidden in targeted active liposomes can selectively act on cancer cells. In this syste...
Source: International Journal of Biological Macromolecules - May 2, 2024 Category: Biochemistry Authors: Eskandar Moghimipour Somayeh Handali Source Type: research
Synthesis, In Silico Prediction, and In Vitro Evaluation of Anti-tumor Activities of Novel 4'-Hydroxybiphenyl-4-carboxylic Acid Derivatives as EGFR Allosteric Site Inhibitors
CONCLUSION: Compound S4 is a promising EGFR tyrosine kinase allosteric inhibitor that warrants further research.PMID:38693732 | DOI:10.2174/0109298673305163240427065543 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - May 2, 2024 Category: Chemistry Authors: Wurood A Shihab Ammar A Razzak Kubba Lubna H Tahtamouni Khaled M Saleh Mai F AlSakhen Sana I Kanaan Abdulrahman M Saleh Salem R Yasin Source Type: research
Elevated serum homocysteine levels associated with poor recurrence-free and overall survival in patients with colorectal cancer
This study aimed to evaluate the significance of homocysteine (HCY) levels in predicting recurrence-free survival (RFS) and overall survival (OS) in colorectal cancer (CRC) patients. This retrospective study involved 1272 CRC patients. The risk of mortality increased with increasing HCY levels in CRC patients. The optimal HCY cutoff value in CRC patients was 15.2 μmol/L. The RFS (45.8% vs. 60.5%, p < 0.001) and OS (48.2% vs. 63.2%, p < 0.001) of patients with high HCY levels were significantly lower than those of patients with low HCY levels. Patients with high HCY levels were older, male, had large tumours, high ca...
Source: Anal Sci - May 2, 2024 Category: Chemistry Authors: Hailun Xie Lishuang Wei Qiwen Wang Shuangyi Tang Jialiang Gan Source Type: research
Apoptotic effect of 5-fluorouracil-doxorubicin combination on colorectal cancer cell monolayers and spheroids
CONCLUSION: The results indicated that the 5-FU + DOX combination therapy induces apoptosis and renders 5-FU and DOX more effective at lower concentrations compared to their alone use. This study reveals promising results in reducing the potential side effects of treatment by enabling the use of lower drug doses.PMID:38698270 | DOI:10.1007/s11033-024-09562-x (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - May 2, 2024 Category: Molecular Biology Authors: Sema Bilgin Source Type: research
Longitudinal associations of diurnal rest-activity rhythms with fatigue, insomnia, and health-related quality of life in survivors of colorectal cancer up to 5 years post-treatment
CONCLUSIONS: In the first five years after CRC treatment, adhering to a generally more active (mesor) and consistent (24-h autocorrelation) RAR, with a pronounced peak activity (amplitude) and a marked difference between daytime and nighttime activity (dichotomy index) was found to be associated with lower fatigue, lower insomnia, and a better HRQoL. Future intervention studies are needed to investigate if restoring RAR among survivors of CRC could help to alleviate symptoms of fatigue and insomnia while enhancing their HRQoL.TRIAL REGISTRATION: EnCoRe study NL6904 ( https://www.onderzoekmetmensen.nl/ ).PMID:38698447 | DOI...
Source: Health Physics - May 2, 2024 Category: Physics Authors: Marvin Y Chong Koen G Frenken Simone J P M Eussen Annemarie Koster Gerda K Pot St éphanie O Breukink Maryska Janssen-Heijnen Eric T P Keulen Wouter Bijnens Laurien M Buffart Kenneth Meijer Frank A J L Scheer Karen Steindorf Judith de Vos-Geelen Matty P W Source Type: research
Curvilinear catheter implantation in HDR prostate brachytherapy: feasibility study
CONCLUSION: This work demonstrates the feasibility of using tendon-driven active curvilinear catheter implantation in prostate to improve the outcomes of HDR-BT via improved radiation dose distribution to the prostate and reduced toxicity to the OARs.PMID:38695825 | DOI:10.1002/mp.17113 (Source: Health Physics)
Source: Health Physics - May 2, 2024 Category: Physics Authors: Blayton Padasdao Rex Imanaka Tarun K Podder Bardia Konh Source Type: research
Apoptotic effect of 5-fluorouracil-doxorubicin combination on colorectal cancer cell monolayers and spheroids
CONCLUSION: The results indicated that the 5-FU + DOX combination therapy induces apoptosis and renders 5-FU and DOX more effective at lower concentrations compared to their alone use. This study reveals promising results in reducing the potential side effects of treatment by enabling the use of lower drug doses.PMID:38698270 | DOI:10.1007/s11033-024-09562-x (Source: Mol Biol Cell)
Source: Mol Biol Cell - May 2, 2024 Category: Molecular Biology Authors: Sema Bilgin Source Type: research
Evaluating complete response prediction rates in locally advanced rectal cancer with different radiomics segmentation approaches
CONCLUSION: Although the highest AUC result is obtained from the tumor segmentation, the highest accuracy and sensitivity are detected with tumor+mesorectum segmentation and these findings align with previous studies, suggesting that the mesorectum contains valuable insights for CR. The lowest result is obtained with CTV segmentation. More studies with mesorectum and pelvic nodal regions included in segmentation are needed.PMID:38694706 | PMC:PMC11061551 | DOI:10.3389/pore.2024.1611744 (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - May 2, 2024 Category: Pathology Authors: Gizem Kaval Merve Gulbiz Dagoglu Kartal Sena Azamat Eda Cingoz Gokhan Ertas Sule Karaman Basak Kurtuldu Metin Keskin Neslihan Berker Senem Karabulut Ethem Nezih Oral Nergiz Dagoglu Sakin Source Type: research
Concurrent ascending colon adenocarcinoma and colonic tuberculosis: a case report from Syria
CONCLUSION: The two diseases may co-exist; thus, diagnosing them may not be the easiest, not to mention the lack of a clear treatment protocol in case of their accompany.PMID:38694366 | PMC:PMC11060274 | DOI:10.1097/MS9.0000000000001927 (Source: Annals of Medicine)
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Basel Ahmad Suzana Durra Sabine Tayfour Sandra Habka Bassel Albatal Mohamad Ahmad Source Type: research
Individualized prediction of conditional survival for colorectal signet-ring cell carcinoma patients
CONCLUSIONS: The probability of achieving 5-year OS and 5-year CSS in colorectal SRCC patients improved gradually with additional time. Conditional nomograms considering survival time will be more reliable and informative for risk stratification and postoperative follow-up.PMID:38694354 | PMC:PMC11060288 | DOI:10.1097/MS9.0000000000001982 (Source: Annals of Medicine)
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Jiani Gu Lijun Zhang Yanjin Zhang Xia Chen Ting Gu Jidong Cai Lifeng Yao Lihua Yan Source Type: research
Real ‐world safety and effectiveness of anamorelin for cancer cachexia: Interim analysis of post‐marketing surveillance in Japan
ConclusionThe overall safety of anamorelin raised no new safety concerns, although continued caution may be required for hyperglycemia and nausea. Improvements in BW and appetite were also observed in real-world clinical settings. (Source: Cancer Medicine)
Source: Cancer Medicine - May 2, 2024 Category: Cancer & Oncology Authors: Koichi Takayama,
Ai Kojima,
Chikara Honda,
Masahiro Nakayama,
Satomi Kanemata,
Toshimitsu Endo,
Kei Muro Tags: RESEARCH ARTICLE Source Type: research
Longitudinal associations of diurnal rest-activity rhythms with fatigue, insomnia, and health-related quality of life in survivors of colorectal cancer up to 5 years post-treatment
There is a growing population of survivors of colorectal cancer (CRC). Fatigue and insomnia are common symptoms after CRC, negatively influencing health-related quality of life (HRQoL). Besides increasing phys... (Source: International Journal of Behavioral Nutrition and Physical Activity)
Source: International Journal of Behavioral Nutrition and Physical Activity - May 2, 2024 Category: Nutrition Authors: Marvin Y. Chong, Koen G. Frenken, Simone J. P. M. Eussen, Annemarie Koster, Gerda K. Pot, St éphanie O. Breukink, Maryska Janssen-Heijnen, Eric T. P. Keulen, Wouter Bijnens, Laurien M. Buffart, Kenneth Meijer, Frank A. J. L. Scheer, Karen Steindorf, Judi Tags: Research Source Type: research
Association of healthy diet score and adiposity with risk of colorectal cancer: findings from the UK Biobank prospective cohort study
ConclusionAdiposity-mediated effects were limited in the link between dietary patterns and CRC incidence, implying that solely addressing adiposity may not sufficiently reduce CRC risk. Interventions, such as improving dietary quality in people with adiposity or promoting weight control in those with unhealthy eating habits, may provide an effective strategy to reduce CRC risk. (Source: European Journal of Nutrition)
Source: European Journal of Nutrition - May 2, 2024 Category: Nutrition Source Type: research
Addressing Colorectal Cancer Disparities in Unhoused Populations: A Call for Equitable Access and Compassionate Care
Clin Colon Rectal Surg DOI: 10.1055/s-0044-1786531Housing is essential for health. Unhoused individuals have markedly worse health status than the general population culminating in higher rates of premature mortality. Cancer is a leading cause of death in older unhoused adults. Caring for unhoused patients at risk for or with colorectal cancer poses challenges at every stage of oncologic care: prevention, screening, diagnosis, treatment, and follow-up. These challenges result in later stages at diagnosis and worse overall survival. Health systems can work to advance health equity in colorectal cancer in unhoused patients b...
Source: Clinics in Colon and Rectal Surgery - May 2, 2024 Category: Surgery Authors: Decker, Hannah Erickson, Caroline Wick, Elizabeth Tags: Review Article Source Type: research
Correction: Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/ GPX4 expression
(Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - May 2, 2024 Category: Cancer & Oncology Authors: Yaya Qiao, Meng Su, Huifang Zhao, Huanle Liu, Chenxi Wang, Xintong Dai, Lingling Liu, Guangju Liu, Huanran Sun, Mingming Sun, Jiyan Wang, Zhen Li, Jun Fan, Quan Zhang, Chunshen Li, Fangmin Situ & hellip; Tags: Correction Source Type: research
