Decreased interleukin ‐17RA expression is associated with good prognosis in patients with colorectal cancer and inhibits tumor growth and vascularity in mice
ConclusionReduced IL-17RA expression also suppressed cellular proliferation, migration, and invasion, and the expression of EMT genes. Knockdown of IL-17RA inhibited tumor growth and vascularity and decreased the population of Tregs and MDSCs in mouse tumors. Overall, IL-17RA expression was identified to be independently associated with the prognosis of patients with CRC. (Source: Cancer Medicine)
Source: Cancer Medicine - March 17, 2024 Category: Cancer & Oncology Authors: Jeng ‐Kai Jiang, Chi‐Hung Lin, Ting‐An Chang, Liang‐Chuan Lo, Chien‐Ping Lin, Ruey‐Hwa Lu, Chih‐Yung Yang Tags: RESEARCH ARTICLE Source Type: research

Ultrasound ‐guided percutaneous high‐frequency irreversible electroporation in porcine livers using four electrode needles: A feasibility and safety study
ConclusionsThis study demonstrated the feasibility and safety of ultrasound-guided percutaneous H-FIRE ablation in porcine livers in  vivo, and proposed a four-needle method to optimize its clinical application. (Source: Cancer Medicine)
Source: Cancer Medicine - March 16, 2024 Category: Cancer & Oncology Authors: Chang ‐Tian Li, Guo‐Dong Zhao, Wen‐Bo Zou, Zhen‐Hua Zhang, Yi Zhao, Rong Liu Tags: RESEARCH ARTICLE Source Type: research

Cancer incidence among Armenians in California
ConclusionWe observed higher stomach, colorectal and thyroid cancer incidence among males and females, and tobacco-related cancers among males. Further research is needed to refine Armenian population estimates and understand and address risk factors associated with specific cancers among Armenians in California. (Source: Cancer Medicine)
Source: Cancer Medicine - March 16, 2024 Category: Cancer & Oncology Authors: Ani S. Movsisyan  Vernon, Jeffrey S. Hoch, Laura Fejerman, Theresa H. Keegan Tags: RESEARCH ARTICLE Source Type: research

A survey of carboplatin desensitization therapy in Japan: A multicenter retrospective study
ConclusionAlthough carboplatin desensitization therapy has high success rates in Japan, erythema and pruritus are important HSRs to consider. (Source: Cancer Medicine)
Source: Cancer Medicine - March 16, 2024 Category: Cancer & Oncology Authors: Hiroaki Komatsu, Koji Matsumoto, Mitsunori Morita, Takayuki Nagasawa, Hiroshi Nishio, Jiro Suzuki, Shin Nishio, Hisanori Kobara, Mayu Yunokawa, Kazuya Ariyoshi, Takashi Hirayama, Hideki Tokunaga, Masayo Ukita, Kaori Yoriki, Mayuyo Mori ‐Uc Tags: RESEARCH ARTICLE Source Type: research

The outcome in patients with BRAF ‐mutated metastatic melanoma treated with anti‐programmed death receptor‐1 monotherapy or targeted therapy in the real‐world setting
ConclusionsPresent real-world data document the high effectiveness of immunotherapy and targeted therapy. Although targeted therapy had higher response rates, immunotherapy improved PFS and OS. While the prognostic value of LDH was confirmed, the potential use of blood cell count-derived parameters to predict outcomes needs further investigation. (Source: Cancer Medicine)
Source: Cancer Medicine - March 16, 2024 Category: Cancer & Oncology Authors: Jind řich Kopecký, Marek Pásek, Radek Lakomý, Bohuslav Melichar, Ivona Mrazová, Ondřej Kubeček, Monika Arenbergerová, Radmila Lemstrová, Alžběta Švancarová, Vojtěch Tretera, Alžběta Hlodáková, Kamila Žváčková Tags: RESEARCH ARTICLE Source Type: research

Exploring the relation of active surveillance schedules and prostate cancer mortality
ConclusionThe detection delay is confirmed as a surrogate for prostate cancer mortality. A cut-off for a “safe” detection delay could not be identified. (Source: Cancer Medicine)
Source: Cancer Medicine - March 16, 2024 Category: Cancer & Oncology Authors: Zhenwei Yang, Eveline A. M. Heijnsdijk, Lisa F. Newcomb, Dimitris Rizopoulos, Nicole S. Erler Tags: RESEARCH ARTICLE Source Type: research

Effect of the SARS ‐CoV‐2 pandemic on colorectal cancer diagnosis and prognosis
ConclusionsThe COVID-19 pandemic has led to a decrease in the number of diagnosed CRC cases and in the proportion of stage I CRC. The reduction in the number of colonoscopies and CRC diagnoses was higher in centers that applied universal SARS-CoV-2 PCR screening before colonoscopy. In addition, the COVID-19 pandemic has affected curative treatment of rectal cancers. (Source: Cancer Medicine)
Source: Cancer Medicine - March 16, 2024 Category: Cancer & Oncology Authors: Luc ía Medina‐Prado, Noelia Sala‐Miquel, Marta Aicart‐Ramos, Julia López‐Cardona, Marta Ponce‐Romero, Oswaldo Ortíz, María Pellisé, Lara Aguilera, Pilar Díez‐Redondo, Henar Núñez‐Rodríguez, Agustín Seoane, María‐José Tags: RESEARCH ARTICLE Source Type: research

EXERT ‐BC: A pilot study of an exercise regimen designed to improve functional mobility, body composition, and strength after the treatment for breast cancer
ConclusionA 3-month dose-escalated resistance training regimen comprising high-intensity compound movements appears safe with a high degree of adherence among breast cancer survivors, resulting in demonstrable improvements in body composition, metabolic parameters, strength increases, and patient-reported quality of life. (Source: Cancer Medicine)
Source: Cancer Medicine - March 16, 2024 Category: Cancer & Oncology Authors: David J. Carpenter, Chris Peluso, Christie Hilton, Frank Velasquez, Adam Annichine, Krista Matsko, Jared Rosenberg, Alexander K. Diaz, Parker Hyde, Sushil Beriwal, Colin E. Champ Tags: RESEARCH ARTICLE Source Type: research

Notch signaling genes and CD8+ T ‐cell dynamics: Their contribution to immune‐checkpoint inhibitor therapy in oral squamous cell carcinoma: A retrospective study
This study may enable better selection of ICI therapy with CD8+ T-cell infiltration via PD-L1 expression for oral squamous cell carcinoma patients with mutations in Notch signaling pathway. (Source: Cancer Medicine)
Source: Cancer Medicine - March 16, 2024 Category: Cancer & Oncology Authors: Kazuhiro Ogi, Takahiro Iwamoto, Takashi Sasaya, Koyo Nishiyama, Takaaki Tokura, Takanori Sasaki, Hironari Dehari, Yohei Arihara, Kazuyuki Murase, Masato Saito, Masanori Someya, Kohichi Takada, Akihiro Miyazaki Tags: BRIEF COMMUNICATION Source Type: research

Integrating natural compounds and nanoparticle ‐based drug delivery systems: A novel strategy for enhanced efficacy and selectivity in cancer therapy
AbstractCancer remains a leading cause of death worldwide, necessitating the development of innovative and more effective treatment strategies. Conventional cancer treatments often suffer from limitations such as systemic toxicity, poor pharmacokinetics, and drug resistance. Recently, there has been growing attention to utilizing natural compounds derived from various sources as possible cancer therapeutics. Natural compounds have demonstrated diverse bioactive properties, including antioxidant, anti-inflammatory, and antitumor effects, making them attractive candidates for cancer treatment. However, their limited solubili...
Source: Cancer Medicine - March 16, 2024 Category: Cancer & Oncology Authors: Asma Manzari ‐Tavakoli, Amirhesam Babajani, Maryam Manzari Tavakoli, Fahimeh Safaeinejad, Ameneh Jafari Tags: REVIEW Source Type: research

Cardiovascular/anti ‐inflammatory drugs repurposed for treating or preventing cancer: A systematic review and meta‐analysis of randomized trials
Conclusions and RelevanceDespite promising pre-clinical and population-based data, cardiovascular drugs and anti-inflammatory medications have overall not demonstrated benefit in the treatment or preventing recurrence of cancer. These findings may help guide future potential clinical trials involving these medications when applied in oncology. (Source: Cancer Medicine)
Source: Cancer Medicine - March 16, 2024 Category: Cancer & Oncology Authors: David J. Benjamin, Alyson Haslam, Vinay Prasad Tags: RESEARCH ARTICLE Source Type: research

Reduced ‐dose chemotherapy followed by blinatumomab in induction therapy for newly diagnosed B‐cell acute lymphoblastic leukemia
ConclusionsBlinatumomab demonstrated a significant improvement in clinical outcomes in patients with newly diagnosed B-ALL irrespective of their poor-risk factor status and the pretreatment blast burden. (Source: Cancer Medicine)
Source: Cancer Medicine - March 16, 2024 Category: Cancer & Oncology Authors: Jing Lu, Huifen Zhou, Xin Zhou, Yonggong Yang, Laigen Tong, Miao Miao, Xiaofei Yang, Suning Chen Tags: BRIEF COMMUNICATION Source Type: research

Construction and validation of machine learning models for predicting distant metastases in newly diagnosed colorectal cancer patients: A large ‐scale and real‐world cohort study
ConclusionThe RF-based model accurately predicted the likelihood of DM and identified patients with CRC in the high-risk group, providing guidance for personalized clinical decision-making. (Source: Cancer Medicine)
Source: Cancer Medicine - March 16, 2024 Category: Cancer & Oncology Authors: Ran Wei, Guanhua Yu, Xishan Wang, Zheng Jiang, Xu Guan Tags: RESEARCH ARTICLE Source Type: research

Novel metabolic biomarker for early detection and diagnosis to the patients with gastric cardia adenocarcinoma
ConclusionsA total of 25 common and stable differential metabolites may hold promise as liquid non-invasive indicators for GCA diagnosis. HER2 may function as a tumor suppressor gene in GCA, as its overexpression is associated with improved survival. The downregulation of bile acid metabolism in GCA may offer valuable theoretical insights and innovative approaches for precision-targeted treatments in GCA patients. (Source: Cancer Medicine)
Source: Cancer Medicine - March 16, 2024 Category: Cancer & Oncology Authors: Meng Xia Wei, Zheng Yang, Pan Pan Wang, Xue Ke Zhao, Xin Song, Rui Hua Xu, Jing Feng Hu, Kan Zhong, Ling Ling Lei, Wen Li Han, Miao Miao Yang, Fu You Zhou, Xue Na Han, Zong Min Fan, Jia Li, Ran Wang, Bei Li, Li Dong Wang Tags: RESEARCH ARTICLE Source Type: research

Deep learning ‐based accurate diagnosis and quantitative evaluation of microvascular invasion in hepatocellular carcinoma on whole‐slide histopathology images
ConclusionsWe developed a deep learning diagnostic model, which performed well and improved the efficiency and accuracy of MVI diagnosis. The model provided spatial information of MVI that was essential to accurately predict HCC recurrence after surgery. (Source: Cancer Medicine)
Source: Cancer Medicine - March 15, 2024 Category: Cancer & Oncology Authors: Xiuming Zhang, Xiaotian Yu, Wenjie Liang, Zhongliang Zhang, Shengxuming Zhang, Linjie Xu, Han Zhang, Zunlei Feng, Mingli Song, Jing Zhang, Shi Feng Tags: RESEARCH ARTICLE Source Type: research