Adiposity and breast, endometrial, and colorectal cancer risk in postmenopausal women: Quantification of the mediating effects of leptin, C ‐reactive protein, fasting insulin, and estradiol
ConclusionLeptin, CRP, fasting insulin, and estradiol appear to mediate the effect of high BMI on cancer risk to different extents, with likely varying degrees of importance between cancers. These insights might be important in developing interventions to modify obesity-associated cancer risk in postmenopausal women. (Source: Cancer Medicine)
Source: Cancer Medicine - January 20, 2022 Category: Cancer & Oncology Authors: S. Ghazaleh Dashti, Julie A. Simpson, Vivian Viallon, Amalia Karahalios, Margarita Moreno ‐Betancur, Theodore Brasky, Kathy Pan, Thomas E. Rohan, Aladdin H. Shadyab, Cynthia A. Thomson, Robert A. Wild, Sylvia Wassertheil‐Smoller, Gloria Y. Tags: RESEARCH ARTICLE Source Type: research

Measurable residual disease, FLT3 ‐ITD mutation, and disease status have independent prognostic influence on outcome of allogeneic stem cell transplantation in NPM1‐mutated acute myeloid leukemia
This study examines the aggregate influence of those factors on outcome post-transplant in NPM1-mutated AML. AbstractNucleophosmin-1 (NPM1) mutations in acute myeloid leukemia (AML) confer a survival advantage in the absence ofFLT3-internal tandem duplication (FLT3-ITD). Here, we investigated the main predictors of outcome after allogeneic hematopoietic stem cell transplantation (allo-HCT). We identified 1572 adult (age ≥ 18 year) patients withNPM1-mutated AML in first complete remission (CR1:78%) or second complete remission (CR2:22%) who were transplanted from matched sibling donors (30.8%) or unrelated donors (57.4%...
Source: Cancer Medicine - January 20, 2022 Category: Cancer & Oncology Authors: Rama Al Hamed, Myriam Labopin, Etienne Daguindau, Riitta Niittyvuopio, Anne Huynh, Gerard Soci é, Micha Srour, Jean Henri Bourhis, Nicolaus Kröger, Eleni Tholouli, Goda Choi, Xavier Poiré, Hans Martin, Marie‐Thérèse Rubio, Pavel Jindr Tags: RESEARCH ARTICLE Source Type: research

Coexistence of superficial carcinogenesis of resident epithelium besides neuroendocrine neoplasm of the digestive tract
ConclusionsThese findings suggested a potential “paratransformation” or “bystander effect” in resident epithelium by NENs. Thus, “bystander carcinogenesis” could be a pathogenic mechanism of resident epithelium transformation adjacent to NENs in the esophagogastrointestinal tract. (Source: Cancer Medicine)
Source: Cancer Medicine - January 20, 2022 Category: Cancer & Oncology Authors: Hiroyuki Kuwano, Takehiko Yokobori, Munenori Ide, Hiroshi Saeki, Makoto Sohda, Makoto Sakai, Tomonori Yoshida, Kengo Kuriyama, Kyoichi Ogata, Hiroomi Ogawa, Takuhisa Okada, Tatsuya Miyazaki, Shunsuke Takahashi, Ken Shirabe Tags: RESEARCH ARTICLE Source Type: research

A B ‐Raf V600E gene signature for melanoma predicts prognosis and reveals sensitivity to targeted therapies
ConclusionThe BRAF signature may better help guide targeted therapy for melanoma, and such a framework can be applied to other cancers and mutations to provide more information than mutation status alone. (Source: Cancer Medicine)
Source: Cancer Medicine - January 19, 2022 Category: Cancer & Oncology Authors: Kevin Yao, Emily Zhou, Chao Cheng Tags: RESEARCH ARTICLE Source Type: research

Glycan signatures for the identification of cisplatin ‐resistant testicular cancer cell lines: Specific glycoprofiling of human chorionic gonadotropin (hCG)
ConclusionThe results suggest that one particular lectinDolichos biflorus agglutinin (DBA) can selectively discriminate sensitive TC cell lines from resistant TC cell lines. Moreover, there are additional lectins which can provide useful information about the strength of cisplatin resistance. (Source: Cancer Medicine)
Source: Cancer Medicine - January 19, 2022 Category: Cancer & Oncology Authors: Michal Hires, Eduard Jane, Katarina Kalavska, Michal Chovanec, Michal Mego, Peter Kasak, Tomas Bertok, Jan Tkac Tags: RESEARCH ARTICLE Source Type: research

Racial and ethnic variation in multigene panel testing in a cohort of BRCA1/2 ‐negative individuals who had genetic testing in a large urban comprehensive cancer center
ConclusionsUnderstanding the racial and ethnic distribution of pathogenic variants in multi-gene panels has the potential to lead to better identification of individuals at risk for hereditary cancer. (Source: Cancer Medicine)
Source: Cancer Medicine - January 18, 2022 Category: Cancer & Oncology Authors: Sushma Tatineni, Meri Tarockoff, Nadine Abdallah, Kristen  S. Purrington, Hadeel Assad, Rachel Reagle, Nancie Petrucelli, Michael S. Simon Tags: RESEARCH ARTICLE Source Type: research

The initial expression alterations occurring to transcription factors during the formation of breast cancer: Evidence from bioinformatics
ConclusionWe presented differential gene expression profiles among normal, para-cancerous, and BC tissues and further identified candidate genes that might contribute to tumorigenesis and progression of BC, as potential diagnostic and prognostic targets for BC patients. (Source: Cancer Medicine)
Source: Cancer Medicine - January 17, 2022 Category: Cancer & Oncology Authors: Xingxing Dong, Yalong Yang, Gaoran Xu, Zelin Tian, Qian Yang, Yan Gong, Gaosong Wu Tags: RESEARCH ARTICLE Source Type: research

The association of obesity with thyroid carcinoma risk
ConclusionsExcess body fatness in early life and TC survival initiate adverse effects later in life. (Source: Cancer Medicine)
Source: Cancer Medicine - January 15, 2022 Category: Cancer & Oncology Authors: Xiao ‐Ni Ma, Cheng‐Xu Ma, Li‐Jie Hou, Song‐Bo Fu Tags: REVIEW Source Type: research

Missed opportunities for concomitant HPV vaccination among childhood cancer survivors
ConclusionsChildhood cancer survivors have more missed opportunities for concomitant HPV vaccination than a population sample. As flu shots should be administered annually, providers have a regular opportunity to recommend and deliver the HPV vaccine to survivors. (Source: Cancer Medicine)
Source: Cancer Medicine - January 15, 2022 Category: Cancer & Oncology Authors: Joemy M. Ramsay, Heydon K. Kaddas, Judy Y. Ou, Deanna Kepka, Anne C. Kirchhoff Tags: RESEARCH ARTICLE Source Type: research

Trends in the incidence of head and neck cancer by subsite between 1993 and 2015 in Japan
ConclusionsThese findings will assist in focusing on the individual prevention of HNC. (Source: Cancer Medicine)
Source: Cancer Medicine - January 14, 2022 Category: Cancer & Oncology Authors: Daisuke Kawakita, Isao Oze, Shinichi Iwasaki, Tomohiro Matsuda, Keitaro Matsuo, Hidemi Ito Tags: RESEARCH ARTICLE Source Type: research

Pre ‐diagnostic levels of sVEGFR2, sTNFR2, sIL‐2Rα and sIL‐6R are associated with glioma risk: A nested case–control study of repeated samples
In a nested case –control study, we found that the pre-diagnostic levels of sVEGFR2, sTNFR2, sIL-2Rα and sIL-6R were associated with glioma risk. Our findings suggest these proteins play important roles in gliomagenesis. AbstractNo strong aetiological factors have been established for glioma aside from genetic mutations and variants, ionising radiation and an inverse relationship with asthmas and allergies. Our aim was to investigate the association between pre-diagnostic immune protein levels and glioma risk. We conducted a case –control study nested in the Northern Sweden Health and Disease Study cohort. We analysed...
Source: Cancer Medicine - January 14, 2022 Category: Cancer & Oncology Authors: Wendy Yi ‐Ying Wu, Florentin Späth, Carl Wibom, Benny Björkblom, Anna M. Dahlin, Beatrice Melin Tags: RESEARCH ARTICLE Source Type: research

Heterogeneity among tumors with acquired resistance to EGFR tyrosine kinase inhibitors harboring EGFR ‐T790M mutation in non‐small cell lung cancer cells
EGFR-TKI-resistant EGFR T790M-mutant tumors were developed in vivo. A difference in sensitivity to osimertinib was observed between the T790M tumors. A difference in genetic and epigenetic intratumor heterogeneity was observed. AbstractEGFR-T790M mutation is a major mechanism underlying acquired resistance to first- and second-generation EGFR tyrosine kinase inhibitors (EGFR-TKIs) in lung cancer with mutatedEGFR. However, differences in the biological characteristics of T790M tumors based on treatment regimens with each generation of EGFR-TKI are not fully understood. We established cell lines with acquired resistance harb...
Source: Cancer Medicine - January 14, 2022 Category: Cancer & Oncology Authors: Yuki Katayama, Tadaaki Yamada, Shinsaku Tokuda, Naoko Okura, Naoya Nishioka, Kenji Morimoto, Keiko Tanimura, Yoshie Morimoto, Masahiro Iwasaku, Mano Horinaka, Toshiyuki Sakai, Kenji Kita, Seiji Yano, Koichi Takayama Tags: RESEARCH ARTICLE Source Type: research

Relationship between exposure to ionizing radiation and mesothelioma risk: A systematic review of the scientific literature and meta ‐analysis
ConclusionsDespite the low number of mesotheliomas in the general population, the steadily increased risk among individuals exposed to radiation is still worth considering. (Source: Cancer Medicine)
Source: Cancer Medicine - January 14, 2022 Category: Cancer & Oncology Authors: Giovanni Visci, Emanuele Rizzello, Carlotta Zunarelli, Francesco Saverio Violante, Paolo Boffetta Tags: REVIEW Source Type: research

Machine learning to predict waitlist dropout among liver transplant candidates with hepatocellular carcinoma
ConclusionIn summary, a simple, interpretable 5-variable model predicted 3-, 6-, and 12-month waitlist dropout among patients with HCC. This prediction can be used to appropriately prioritize patients with HCC and their imminent need for transplant. (Source: Cancer Medicine)
Source: Cancer Medicine - January 14, 2022 Category: Cancer & Oncology Authors: Allison Kwong, Bilal Hameed, Shareef Syed, Ryan Ho, Hossein Mard, Sahar Arshad, Isaac Ho, Tashfeen Suleman, Francis Yao, Neil Mehta Tags: RESEARCH ARTICLE Source Type: research

The clinicopathological and molecular characteristics of resected EGFR ‐mutant lung adenocarcinoma
ConclusionsConcomitantTP53 mutation andEGFR amplification were poor prognostic factors for RFS in patients withEGFR-mutant resected LUAD. Our findings provide valuable understanding of the impact of concurrent alterations and implication for better implementation of precision therapy for patients. (Source: Cancer Medicine)
Source: Cancer Medicine - January 13, 2022 Category: Cancer & Oncology Authors: Wensheng Zhou, Zhichao Liu, Yanan Wang, Yanwei Zhang, Fangfei Qian, Jun Lu, Huimin Wang, Ping Gu, Minjuan Hu, Ya Chen, Zhengyu Yang, Ruiying Zhao, Yuqing Lou, Baohui Han, Wei Zhang Tags: RESEARCH ARTICLE Source Type: research