Palliative care initiation in pediatric oncology patients: A systematic review
AbstractPalliative care (PC) aims to improve quality of life for patients and their families. The World Health Organization and American Academy of Pediatrics recommend that PC starts at diagnosis for children with cancer. This systematic review describes studies that reported PC timing in the pediatric oncology population. The following databases were searched: PubMed, Web of Science, CINAHL, and PsycInfo databases. Studies that reported time of PC initiation were independently screened and reviewed by 2 researchers. Studies describing pilot initiatives, published prior to 1998, not written in English, or providing no emp...
Source: Cancer Medicine - December 7, 2018 Category: Cancer & Oncology Authors: Brian T. Cheng, Michael Rost, Eva De Clercq, Louisa Arnold, Bernice S. Elger, Tenzin Wangmo Tags: REVIEW Source Type: research

What information do patients want across their cancer journeys? A network analysis of cancer patients ’ information needs
ConclusionIf patients have their information needs met, especially during stages within the cancer journey when information needs are highest, they are more likely to be satisfied with their care. Our study has implications for information giving and improving patient satisfaction in cancer care. (Source: Cancer Medicine)
Source: Cancer Medicine - December 7, 2018 Category: Cancer & Oncology Authors: Yvonne Tran, Klay Lamprell, Brona Nic Giolla Easpaig, Gaston Arnolda, Jeffrey Braithwaite Tags: ORIGINAL RESEARCH Source Type: research

A Bayesian network meta ‐analysis of the efficacy of targeted therapies and chemotherapy for treatment of triple‐negative breast cancer
In conclusion, our results indicated that the addition of bevacizumab to CT was beneficial for TNBC patients, and olaparib had a great effect in PFS and ORR, especially for those with BRCA mutations. When combined with CT, targeted a gents including iniparib, sorafenib, cetuximab, and ipatasertib may have better efficacies for treating TNBC. (Source: Cancer Medicine)
Source: Cancer Medicine - December 7, 2018 Category: Cancer & Oncology Authors: Huihui Chen, Wei Lu, Yixin Zhang, Xuan Zhu, Jiaojiao Zhou, Yiding Chen Tags: ORIGINAL RESEARCH Source Type: research

Honokiol induces apoptosis of lung squamous cell carcinoma by targeting FGF2 ‐FGFR1 autocrine loop
In conclusion, honokiol induced cell apoptosis in lung SCC by targeting the FGF2‐FGFR1 autocrine loop. (Source: Cancer Medicine)
Source: Cancer Medicine - December 5, 2018 Category: Cancer & Oncology Authors: Mengyuan Cen, Yinan Yao, Luyun Cui, Guangdie Yang, Guohua Lu, Liangjie Fang, Zhang Bao, Jianying Zhou Tags: ORIGINAL RESEARCH Source Type: research

Construction of immune ‐related risk signature for renal papillary cell carcinoma
In conclusion, our study constructs a robust 15‐gene signature for predicting KIRP patients’ survival outcome on the bas is of tumor immune environment and may provide possible relationship between prognosis and immune‐related biological function. (Source: Cancer Medicine)
Source: Cancer Medicine - December 5, 2018 Category: Cancer & Oncology Authors: Zhongyu Wang, Qian Song, Zuyi Yang, Jianing Chen, Jun Shang, Wen Ju Tags: ORIGINAL RESEARCH Source Type: research

Delta radiomic features improve prediction for lung cancer incidence: A nested case –control analysis of the National Lung Screening Trial
We demonstrated that combining delta radiomics with baseline radiomics generally improved the performance statistics to predict lung cancer incidence when compared to using only baseline radiomic features. We note inconsistent results in the performance statistics when we comparing overall models compared to models based on nodule size. As such, our findings suggest there is a trade ‐off in terms of performance using nodule size‐specific models vs. an overall model. AbstractBackgroundCurrent guidelines for lung cancer screening increased a positive scan threshold to a 6  mm longest diameter. We extracted radiomic ...
Source: Cancer Medicine - December 1, 2018 Category: Cancer & Oncology Authors: Dmitry Cherezov, Samuel H. Hawkins, Dmitry B. Goldgof, Lawrence O. Hall, Ying Liu, Qian Li, Yoganand Balagurunathan, Robert J. Gillies, Matthew B. Schabath Tags: ORIGINAL RESEARCH Source Type: research

Validation of the preoperative controlling nutritional status score as an independent predictor in a large Chinese cohort of patients with upper tract urothelial carcinoma
CONUT score independently predicted worse survival in UTUC patients, especially in patients with high ‐grade disease and advanced stage. The addition of CONUT score would improve the predictive accuracy of the multivariate models for survival outcomes. We therefore suggest adding the CONUT score to the traditional predictive model and to the risk stratifications of patients with UTUC. AbstractBackgroundPretreatment controlling nutritional status (CONUT) score is a novel index which was used to predict outcomes in cancer patients. We aim to explore the prognostic significance of CONUT score in patients with upper tract ur...
Source: Cancer Medicine - November 28, 2018 Category: Cancer & Oncology Authors: Hang Xu, Ping Tan, Xi Jin, Jianzhong Ai, Tianhai Lin, Haoran Lei, Lu Yang, Qiang Wei Tags: ORIGINAL RESEARCH Source Type: research

Risk and prognostic factors for endometrial carcinoma after diagnosis of breast or Lynch ‐associated cancers—A population‐based analysis
Women developing endometrial cancer after tamoxifen treatment for breast cancer are more likely to develop tumours with poorer prognostic features and exhibit poorer survival after adjustment for these prognostic features. Results indicate the importance of longer ‐term monitoring of women treated with tamoxifen for cancer symptoms. Report of prior cancer is a significant indicator of MMR pathogenic variant status, but molecular analysis of endometrial tumors at diagnosis is warranted to detect all patients with Lynch Syndrome. AbstractWe hypothesized that endometrial carcinoma (EC) patients with a prior cancer diagnosis...
Source: Cancer Medicine - November 28, 2018 Category: Cancer & Oncology Authors: Sharon E. Johnatty, Colin J. R. Stewart, Deborah Smith, Daniel Buchanan, Yee Leung, Martin K. Oehler, Alison Brand, Penelope M. Webb, Amanda B. Spurdle Tags: ORIGINAL RESEARCH Source Type: research

Clinical significance of glutamate metabotropic receptors in renal cell carcinoma risk and survival
This study assesses the associations of genetic variants in eight glutamate metabotropic receptor (GRM) genes with risk and survival of renal cell carcinoma. It was fond that several variants affect the expression of GRMs, which in turn is correlated with tumour aggressiveness and patient prognosis. AbstractAccumulating evidence suggests the roles of glutamate metabotropic receptors (GRMs) in cancer, in addition to synaptic signalling. The present study assessed the associations of genetic variants in eightGRM genes with regard to risk and overall survival (OS) in 780 renal cell carcinoma (RCC) patients and controls. After...
Source: Cancer Medicine - November 28, 2018 Category: Cancer & Oncology Authors: Chao ‐Yuan Huang, Yu‐Mei Hsueh, Lih‐Chyang Chen, Wei‐Chung Cheng, Chia‐Cheng Yu, Wei‐Jen Chen, Te‐Ling Lu, Kuo‐Jin Lan, Cheng‐Hsueh Lee, Shu‐Pin Huang, Bo‐Ying Bao Tags: ORIGINAL RESEARCH Source Type: research

Promising clinical outcomes of sequential and “Sandwich” chemotherapy and extended involved‐field intensity‐modulated radiotherapy in patients with stage IE/IIE extranodal natural killer/T‐cell lymphoma
Compared with sequential chemotherapy (Ch) and extended involved ‐field intensity‐modulated radiotherapy (EIF‐IMRT), “Sandwich” Ch and EIF‐IMRT and Ch were significantly associated with higher PFS rates and showed a trend toward improved loco‐regional control. EBV DNA copy after treatment is a good index for recurrence and prognosis for stage IE/IIE ENKTL patients. AbstractBackgroundThe optimal treatment for the rare subtype of non ‐Hodgkin lymphoma, extranodal natural killer/T‐cell lymphoma (ENKTL), nasal‐type, has not been clearly defined. The purpose of the study was to investigate the effica...
Source: Cancer Medicine - November 28, 2018 Category: Cancer & Oncology Authors: Han ‐yu Wang, Shao‐qing Niu, Yun‐ying Yang, Yi‐yang Li, Hong‐bo Chen, Yu‐jing Zhang Tags: ORIGINAL RESEARCH Source Type: research

Association between breast cancer and thyroid cancer: A study based on 13  978 patients with breast cancer
ConclusionsWe observed high co ‐occurrence of TC in patients with BC. There might be different mechanisms behind synchronous and metachronous BC‐TC. (Source: Cancer Medicine)
Source: Cancer Medicine - November 27, 2018 Category: Cancer & Oncology Authors: Nai ‐si Huang, Xing‐xing Chen, Wen‐jun Wei, Miao Mo, Jia‐ying Chen, Ben Ma, Shu‐wen Yang, Wei‐bo Xu, Jiong Wu, Qing‐hai Ji, Xiao‐mao Guo, Guang‐yu Liu, Zhi‐min Shao, Yu Wang Tags: ORIGINAL RESEARCH Source Type: research

Pretreatment values of bilirubin and albumin are not prognostic predictors in patients with advanced pancreatic cancer
ConclusionsBaseline bilirubin and serum proteins were not associated with the prognosis of advanced pancreatic cancer. Tumor location and level of CA19 ‐9 may serve as significant indicators for poor prognosis in those patients. (Source: Cancer Medicine)
Source: Cancer Medicine - November 26, 2018 Category: Cancer & Oncology Authors: Lanyun Feng, Shihui Gu, Peng Wang, Hao Chen, Zhen Chen, Zhiqiang Meng, Luming Liu Tags: ORIGINAL RESEARCH Source Type: research

CD44v9 is associated with epithelial ‐mesenchymal transition and poor outcomes in esophageal squamous cell carcinoma
CD44v9 expression at the tumor invasive front is associated with the EMT, tumor invasion. Moreover, CD44v9 expression at the TIF was an independent prognostic factor of overall survival and recurrence ‐free survival. We conclude that CD44v9 represents a novel prognostic biomarker and a potential therapeutic target for ESCC. AbstractCD44 serves as a marker of cancer stem cells. Alternative splicing generates the CD44v9 isoform. Cancer stem cells are associated with the epithelial ‐mesenchymal transition in cancers, although little is known about their role in esophageal squamous cell carcinoma. Here, we aimed to clarify...
Source: Cancer Medicine - November 26, 2018 Category: Cancer & Oncology Authors: Daisuke Taniguchi, Hiroshi Saeki, Yuichiro Nakashima, Kensuke Kudou, Ryota Nakanishi, Nobuhide Kubo, Koji Ando, Eiji Oki, Yoshinao Oda, Yoshihiko Maehara Tags: ORIGINAL RESEARCH Source Type: research

A novel lncRNA ‐miRNA‐mRNA network analysis identified the hub lncRNA RP11‐159F24.1 in the pathogenesis of papillary thyroid cancer
In conclusion, this study has constructed a PTC‐related lncRNA‐miRNA‐mRNA network and identified the hub lncRNA RP11‐159F24.1 in the tumorigenesis, which prov ided novel insights to explore the underlying mechanism of PTC. (Source: Cancer Medicine)
Source: Cancer Medicine - November 26, 2018 Category: Cancer & Oncology Authors: Wei Jiang, Hua Zhan, Yanyan Jiao, Sha Li, Weixu Gao Tags: ORIGINAL RESEARCH Source Type: research

Surgery vs. radiotherapy for locally advanced hypopharyngeal cancer in the contemporary era: A population ‐based study
ConclusionsChemoradiotherapy for locally advanced hypophagyngeal cancer showed a comparable OS rate to surgery. For patients with T4a category cancer with high possibility of preserving the laryngopharyngeal function, chemoradiotherapy may be a promising alternative treatment. (Source: Cancer Medicine)
Source: Cancer Medicine - November 26, 2018 Category: Cancer & Oncology Authors: Yi ‐Jun Kim, Rena Lee Tags: ORIGINAL RESEARCH Source Type: research

Second primary cancer after female breast cancer: Familial risks and cause of death
ConclusionsFamily history contributed to the excess number of patients with SPCs, and SPC was the leading cause of death in patients with SPC. Taking family history at diagnosis of BC may provide warning signs with regard to possible subsequent SPCs and may offer possibilities for counseling, intervention and management. (Source: Cancer Medicine)
Source: Cancer Medicine - November 26, 2018 Category: Cancer & Oncology Authors: Guoqiao Zheng, Akseli Hemminki, Asta F örsti, Jan Sundquist, Kristina Sundquist, Kari Hemminki Tags: ORIGINAL RESEARCH Source Type: research

The prognostic significance of circulating tumor cells in head and neck and non ‐small‐cell lung cancer
This study demonstrated that CTCs are predictive of poorer outcomes in HNC and provides distinct and separate utility for CTCs in HNC and NSCLC, which may be more representative of the disease burden and overall survival than the parameters used to measure them. (Source: Cancer Medicine)
Source: Cancer Medicine - November 22, 2018 Category: Cancer & Oncology Authors: Arutha Kulasinghe, Joanna Kapeleris, Rebecca Kimberley, Stephen R. Mattarollo, Erik W. Thompson, Jean ‐Paul Thiery, Liz Kenny, Ken O’Byrne, Chamindie Punyadeera Tags: ORIGINAL RESEARCH Source Type: research

The current state and future perspectives of cannabinoids in cancer biology
Cancer Medicine, Volume 7, Issue 11, Page 5859-5859, November 2018. (Source: Cancer Medicine)
Source: Cancer Medicine - November 21, 2018 Category: Cancer & Oncology Tags: CORRIGENDUM Source Type: research

Issue Information
Cancer Medicine, Volume 7, Issue 11, Page 5323-5324, November 2018. (Source: Cancer Medicine)
Source: Cancer Medicine - November 21, 2018 Category: Cancer & Oncology Tags: ISSUE INFORMATION Source Type: research

Squamous cell carcinoma of the rectum: Practice trends and patient survival
Using the NCDB, outcomes from squamous cell carcinoma of the rectum are identified. The current trend in management for locally advanced disease is chemotherapy and radiation, with no survival improvement noted when surgery is added. AbstractPurposeLeverage the National Cancer Database (NCDB) to evaluate trends in management of nonmetastatic squamous cell cancer (SCC) of the rectum and their effect on survival for this uncommon tumor.Methods and MaterialsRetrospective data was obtained from the NCDB for patients diagnosed with SCC of the rectum between 2004 and 2014, including cT1 ‐4, cN0‐2, cM0 tumors (cohort A, n&nbs...
Source: Cancer Medicine - November 20, 2018 Category: Cancer & Oncology Authors: Sunil W. Dutta, Clayton E. Alonso, Mark R. Waddle, Shiv R. Khandelwal, Einsley ‐Marie Janowski, Daniel M. Trifiletti Tags: ORIGINAL RESEARCH Source Type: research

Demographics, stage distribution, and relative roles of surgery and radiotherapy on survival of persons with primary prostate sarcomas
ConclusionsDisease ‐specific survival and OS for non‐rhabdomyosarcoma histologies appear inferior to those of rhabdomyosarcoma. The addition of RT to surgical resection may improve DSS in locally advanced non‐rhabdomyosarcoma. This is the largest report of the incidence, stage distribution, and survival for this extremely rare urologic malignancy providing valuable prognostic information. (Source: Cancer Medicine)
Source: Cancer Medicine - November 19, 2018 Category: Cancer & Oncology Authors: Jonathan D. Tward, Matthew M. Poppe, Ying J. Hitchcock, Brock O ’Neil, Daniel J. Albertson, Dennis C. Shrieve Tags: ORIGINAL RESEARCH Source Type: research

Hypothyroidism is associated with worse outcomes of hepatocellular carcinoma patients after liver transplantation
ConclusionHypothyroidism is associated with poorer overall and recurrence ‐free survival of HCC patients receiving liver transplantation. These results require validation. (Source: Cancer Medicine)
Source: Cancer Medicine - November 19, 2018 Category: Cancer & Oncology Authors: Ning Zhang, Weidong Jin, Shuangnan Zhou, Ju Dong Yang, William S. Harmsen, Nasra H. Giama, Nicha Wongjarupong, Julie K. Heimbach, Kymberly D. Watt, Harmeet Malhi, Terry M. Therneau, Lewis R. Roberts Tags: ORIGINAL RESEARCH Source Type: research

Rs3212986 polymorphism, a possible biomarker to predict smoking ‐related lung cancer, alters DNA repair capacity via regulating ERCC1 expression
In this study, seven candidate SNPs in 3′UTR of DRC‐related genes includingERCC1 (rs3212986, rs2336219, and rs735482),OGG1 (rs1052133),MLH3 (rs108621),CD3EAP (rs1007616), andPPP1R13L (rs6966) were analyzed in 300 lung cancer patients and controls from the northeast of China. Furthermore, we introducedERCC1 (CDS+3 ′UTR) orCD3EAP (CDS) cDNA clone to transfect HEK293T and 16HBE cells. Cell viability between different genotypes of transfected cells exposed to BPDE was detected by CCK ‐8 assay, while DNA damage was visualized using γH2AX immunofluorescence and the modified comet assay. We found that minor ...
Source: Cancer Medicine - November 19, 2018 Category: Cancer & Oncology Authors: Tao Yu, Ping Xue, Su Cui, Liang Zhang, Guopei Zhang, Mingyang Xiao, Xiao Zheng, Qianye Zhang, Yuan Cai, Cuihong Jin, Jinghua Yang, Shengwen Wu, Xiaobo Lu Tags: ORIGINAL RESEARCH Source Type: research

Improved long ‐term patient‐reported health and well‐being outcomes of early‐stage breast cancer treated with partial breast proton therapy
This study compares patient‐reported QoL outcomes among women with stage 0‐2 di sease treated via lumpectomy followed by whole breast irradiation (WBI) or partial breast proton irradiation (PBPT).MethodsIn this cross ‐sectional study, 129 participants evaluated QoL several years post‐treatment by responding to subjective instruments, including established scalar questionnaires and self‐report measures. Responses were averaged between the two groups.ResultsAt 6.5  years (median) postdiagnosis, participants’ demographic, and clinical characteristics were similar. Patient‐reported outcomes were reported...
Source: Cancer Medicine - November 19, 2018 Category: Cancer & Oncology Authors: Sandra L. Teichman, Sharon Do, Sharon Lum, Theodore S. Teichman, William Preston, Shelly E. Cochran, Carlos A. Garberoglio, Roger Grove, Carol A. Davis, Jerry D. Slater, David A. Bush Tags: ORIGINAL RESEARCH Source Type: research

Doxorubicin ‐induced heart failure in cancer patients: A cohort study based on the Korean National Health Insurance Database
In cancer patients treated with doxorubicin, management of risk factors, early detection, and treatment for doxorubicin ‐induced HF might be critical for patient survival. Because the data from Asian population in terms of cardio‐oncology are scarce, our study tried to fill that gap. AbstractBackgroundDoxorubicin is a typical anticancer drug that causes cardiomyopathy and heart failure (HF). The aim of our study was to investigate incidence, risk factors for doxorubicin ‐induced HF in Korean cancer patients and their survival rate, utilizing a nationwide population‐based cohort.MethodsWe analyzed 58  541 cance...
Source: Cancer Medicine - November 19, 2018 Category: Cancer & Oncology Authors: Young Ae Kim, Hyunsoon Cho, Nayoung Lee, So ‐Youn Jung, Sung Hoon Sim, In Hae Park, Sunmi Lee, Eun Sook Lee, Hak Jin Kim Tags: ORIGINAL RESEARCH Source Type: research

Suramin, screened from an approved drug library, inhibits HuR functions and attenuates malignant phenotype of oral cancer cells
In this study, we screened 1570 compounds in the approved drug library by differential scanning fluorimetry (DSF) to discover a HuR‐targeted compound. Firstly, 55 compounds were selected by DSF. Then, 8 compounds that sh owed a shift in the melting temperature value in a concentration‐dependent manner were selected by DSF. Of them, suramin, an anti‐trypanosomal drug, binds to HuR, exhibiting fast‐on and fast‐off kinetic behavior on surface plasmon resonance (SPR). We confirmed that suramin significantly decr eased mRNA and protein expression of cyclin A2 and cyclin B1. Thecyclin A2 andcyclin B1 mRNAs were destabi...
Source: Cancer Medicine - November 18, 2018 Category: Cancer & Oncology Authors: Wataru Kakuguchi, Takao Nomura, Tetsuya Kitamura, Satoko Otsuguro, Kazuhiro Matsushita, Masahiro Sakaitani, Katsumi Maenaka, Kanchu Tei Tags: ORIGINAL RESEARCH Source Type: research

A multi ‐institutional retrospective study of carbon‐ion radiotherapy for non‐squamous cell malignant tumors of the nasopharynx: Subanalysis of Japan Carbon‐Ion Radiation Oncology Study Group study 1402 HN
ConclusionsC ‐ion RT provided good LC and OS rates with acceptable toxicity for treatment of non‐squamous cell malignant tumors of the nasopharynx. (Source: Cancer Medicine)
Source: Cancer Medicine - November 18, 2018 Category: Cancer & Oncology Authors: Takanori Abe, Tatsuya Ohno, Masashi Koto, Yusuke Demizu, Hiroaki Suefuji, Hiroshi Tsuji, Tomoaki Okimoto, Yoshiyuki Shioyama, Jun ‐ichi Saitoh, Katsuyuki Shirai, Kenji Nemoto, Takashi Nakano, Tadashi Kamada, Japan Carbon‐Ion Radiation Onc Tags: ORIGINAL RESEARCH Source Type: research

Clinicopathological analysis of primary intestinal diffuse large B ‐cell lymphoma: Prognostic evaluation of CD5, PD‐L1, and Epstein‐Barr virus on tumor cells
ConclusionEBV+ iDLBCL mainly comprised immunodeficiency ‐associated patients, which may highlight the specificity of the intestine. PD‐L1 expression on tumor cells or microenvironment immune cells was found to have an opposite prognostic impact in iDLBCL. (Source: Cancer Medicine)
Source: Cancer Medicine - November 18, 2018 Category: Cancer & Oncology Authors: Eri Ishikawa, Seiichi Kato, Kazuyuki Shimada, Tsutomu Tanaka, Yuka Suzuki, Akira Satou, Kei Kohno, Ayako Sakakibara, Takeshi Yamamura, Masanao Nakamura, Ryoji Miyahara, Hidemi Goto, Shigeo Nakamura, Yoshiki Hirooka Tags: ORIGINAL RESEARCH Source Type: research

Ewing ’s Sarcoma of the Head and Neck: Margins are not just for surgeons
We present a prospective large series (n  = 47) of head and neck Ewing's sarcomas (HNES) homogeneously treated by the Euro‐Ewing 99 trial (EE99) from 1999 to 2014 in France. All our findings plead for a multidisciplinary approach of HNES in specialized centers from the diagnosis to maximize for these young patients the chance of cure w ith a minimum of sequelae. We highlight that margin interpretation is crucial to discuss postoperative radiotherapy indication and should be questioned by a multidisciplinary team beyond the only surgeon and pathologist opinion. AbstractBackground, MethodsTo describe the characte...
Source: Cancer Medicine - November 17, 2018 Category: Cancer & Oncology Authors: Jebrane Bouaoud, Stephane Temam, Nathalie Cozic, Louise Galmiche ‐Rolland, Kahina Belhous, Frederic Kolb, Francois Bidault, Stephanie Bolle, Sarah Dumont, Valerie Laurence, Dominique Plantaz, Marie‐Dominique Tabone, Perrine Marec‐Berard, Tags: ORIGINAL RESEARCH Source Type: research

Surgeon peer network characteristics and adoption of new imaging techniques in breast cancer: A study of perioperative MRI
ConclusionThe characteristics of a surgeon's peer network are associated with their patients ’ subsequent receipt of perioperative MRI. (Source: Cancer Medicine)
Source: Cancer Medicine - November 15, 2018 Category: Cancer & Oncology Authors: Sara S. Tannenbaum, Pamela R. Soulos, Jeph Herrin, Craig E. Pollack, Xiao Xu, Nicholas A. Christakis, Howard P. Forman, James B. Yu, Brigid K. Killelea, Shi ‐Yi Wang, Cary P. Gross Tags: ORIGINAL RESEARCH Source Type: research

Elevated EGFL6 modulates cell metastasis and growth via AKT pathway in nasopharyngeal carcinoma
EGFL6 was detected overexpressed in NPC (tissue, serum, and cell). EGFL6 enhanced the metastasis and growth of NPC in vitro and vivo (nude mice, heat ‐shock zebrafish model). AbstractEpidermal growth factor ‐like domain multiple 6 (EGFL6) is a secreted protein, regulates maintenance and metastasis of cancer cells. Nevertheless, how EGFL6 participates in the progression and tumorigenesis of nasopharyngeal carcinoma (NPC) remains unclear. In our study, EGFL6 was detected highly expressed in 20 NPC tiss ues compared with normal tissues by IHC assay. Then, the level of EGFL6 in NPC serum and NPC cells was explored through ...
Source: Cancer Medicine - November 15, 2018 Category: Cancer & Oncology Authors: Ziyu Zhu, Haosheng Ni, Bo You, Si Shi, Ying Shan, Lili Bao, Bingyue Duan, Yiwen You Tags: ORIGINAL RESEARCH Source Type: research

The power of tumor sizes in predicting the survival of solitary hepatocellular carcinoma patients
We explored the prognostic ability of tumor sizes in 18  591 patients with solitary HCC categorized as T1 and T2 classification. And we believed that AJCC TNM staging system for solitary HCC would be more comprehensive if the tumor size was integrated into T2 classification. Additionally, for T1 patients, the tumor size plays no role in the choice betwe en resection and transplantation. AbstractBackgroundVascular invasion, rather than tumor size, was applied into the 7th edition of the AJCC TNM staging system to predict survival of solitary hepatocellular carcinoma (HCC) patients. However, does this mean tumor size is...
Source: Cancer Medicine - November 14, 2018 Category: Cancer & Oncology Authors: Anli Yang, Weikai Xiao, Dong Chen, Xiaoli Wei, Shanzhou Huang, Ye Lin, Chuanzhao Zhang, Jianwei Lin, Feiwen Deng, Chenglin Wu, Xiaoshun He Tags: ORIGINAL RESEARCH Source Type: research

Long non ‐coding RNA H19 promotes TDRG1 expression and cisplatin resistance by sequestering miRNA‐106b‐5p in seminoma
In this study, using microarray analysis, we found that long non‐cod ing RNA H19 was upregulated while miRNA‐106b‐5p was downregulated in an established cisplatin‐resistant TCam‐2 cell line. Moreover, H19 acts as a miRNA‐106b‐5p sponge and thus impairs the function of miRNA‐106b‐5p on its target gene, TDRG1. Based on these findings, we propose that H1 9 promotes the expression of TDRG1 by sequestering miRNA‐106b‐5p and uses this mechanism to facilitate cell survival in cisplatin‐based chemotherapeutic conditions. These findings elucidate the mechanisms, at least partially, applied to deregulate TDRG...
Source: Cancer Medicine - November 14, 2018 Category: Cancer & Oncology Authors: Jingchao Wei, Yu Gan, Dongyi Peng, Xianzhen Jiang, Riko Kitazawa, Yali Xiang, Yingbo Dai, Yuxin Tang, Jianfu Yang Tags: ORIGINAL RESEARCH Source Type: research

DSCAM ‐AS1 regulates the G1/S cell cycle transition and is an independent prognostic factor of poor survival in luminal breast cancer patients treated with endocrine therapy
In conclusion, DSCAM‐AS1 is a promising clinical therapeutic target that may prolong survival of luminal breast cancer patients treated with endocrine therapy. (Source: Cancer Medicine)
Source: Cancer Medicine - November 14, 2018 Category: Cancer & Oncology Authors: Wei Sun, An ‐Qi Li, Ping Zhou, Yi‐Zhou Jiang, Xi Jin, Yi‐Rong Liu, Ya‐Jie Guo, Wen‐Tao Yang, Zhi‐Ming Shao, Xiao‐En Xu Tags: ORIGINAL RESEARCH Source Type: research

Multiregional radiomics profiling from multiparametric MRI: Identifying an imaging predictor of IDH1 mutation status in glioblastoma
ConclusionsThe radiomics model built with multiregional features from multiparametric MRI has the potential to preoperatively detect the IDH1 mutation status in GBM patients. The multiregional model built with all ‐region features performed better than the single‐region models, while combining age with all‐region features achieved the best performance. (Source: Cancer Medicine)
Source: Cancer Medicine - November 13, 2018 Category: Cancer & Oncology Authors: Zhi ‐Cheng Li, Hongmin Bai, Qiuchang Sun, Yuanshen Zhao, Yanchun Lv, Jian Zhou, Chaofeng Liang, Yinsheng Chen, Dong Liang, Hairong Zheng Tags: ORIGINAL RESEARCH Source Type: research

Patterns and predictors of end ‐of‐life care in older patients with pancreatic cancer
Although hospice enrollment has increased among patients with PDAC, late enrollment still occurs in a substantial proportion of patients. In addition, patients receive high rates of aggressive end ‐of‐life care. Further research is needed to determine effective ways of enhancing end‐of‐life care for patients with PDAC. AbstractBackgroundLittle is known about end ‐of‐life care among patients with pancreatic adenocarcinoma (PDAC). We used the Surveillance, Epidemiology, and End Results‐Medicare linked database to analyze patterns of hospice use and end‐of‐life treatment in patients with PDAC.MethodsWe inclu...
Source: Cancer Medicine - November 13, 2018 Category: Cancer & Oncology Authors: Ryan D. Nipp, Angela C. Tramontano, Chung Yin Kong, Chin Hur Tags: ORIGINAL RESEARCH Source Type: research

Supervised versus autonomous exercise training in breast cancer patients: A multicenter randomized clinical trial
ConclusionThis trial indicates that patients in an exercise program achieve higher fitness levels during supervised than unsupervised training. (Source: Cancer Medicine)
Source: Cancer Medicine - November 10, 2018 Category: Cancer & Oncology Authors: Theresa Westphal, Gabriel Rinnerthaler, Simon Peter Gampenrieder, Josef Niebauer, Josef Thaler, Michael Pfob, David Fuchs, Marina Riedmann, Barbara Mayr, Bernhard Reich, Thomas Melchardt, Brigitte Mlineritsch, Lisa Pleyer, Richard Greil Tags: ORIGINAL RESEARCH Source Type: research

EGFR confers radioresistance in human oropharyngeal carcinoma by activating endoplasmic reticulum stress signaling PERK ‐eIF2α‐GRP94 and IRE1α‐XBP1‐GRP78
EGFR conferred radioresistance in OSCC cells by activating ERS signalling PERK ‐eIF2α‐GRP94 and IRE1α‐XBP1‐GRP78. Knockdown of EGFR in OSCC cells inhibited DNA double‐strand break repair and autophagy mediated by ERS. Co‐expression of EGFR and PERK was associated with poor prognosis of OSCC. AbstractThe activation of epidermal growth factor receptor (EGFR) is associated with radioresistance in malignant tumors. Specifically, radiation can destroy endoplasmic reticulum (ER) homeostasis to induce ER stress (ERS). However, the effect of EGFR ‐mediated regulation of ERS signaling pathway on radiosensi...
Source: Cancer Medicine - November 9, 2018 Category: Cancer & Oncology Authors: Miao Zhang, Ning Han, Yuanjun Jiang, Jie Wang, Gaiyan Li, Xintong Lv, Guang Li, Qiao Qiao Tags: ORIGINAL RESEARCH Source Type: research

Risk factors for brain metastases in patients with non –small‐cell lung cancer
AbstractBrain metastases (BM) are severe incidents in patients with non –small‐cell lung cancer (NSCLC). The controversial value of prophylactic cranial irradiation (PCI) in NSCLC in terms of survival benefit prompted us to explore the possible risk factors for BM in NSCLC and identify the potential population most likely to benefit from PCI. Risk factors for brain metastases in NSCLC are reviewed in this article. Identifying patients with a higher risk of BM could possibly increase the benefit of PCI while reducing the discomfort and risks caused by unnecessary invasive procedures in the NSCLC patient population. ...
Source: Cancer Medicine - November 8, 2018 Category: Cancer & Oncology Authors: Ning An, Wang Jing, Haoyi Wang, Ji Li, Yang Liu, Jinming Yu, Hui Zhu Tags: REVIEW Source Type: research

Pathological tumor infiltrative pattern and sites of initial recurrence in stage II/III gastric cancer: Propensity score matching analysis of a multi ‐institutional dataset
ConclusionsINF may represent an important predictor of recurrence patterns after curative resection of stage II/III gastric cancer. (Source: Cancer Medicine)
Source: Cancer Medicine - November 8, 2018 Category: Cancer & Oncology Authors: Nobuhiko Nakagawa, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Kenta Murotani, Tags: ORIGINAL RESEARCH Source Type: research

Local regression and control of T1 ‐2 nasopharyngeal carcinoma treated with intensity‐modulated radiotherapy
IMRT provided excellent LC for T1 ‐2 NPC. Clinicians should be cautious about the addition of chemotherapy and boost irradiation. Attention should be attached to advanced N stage. AbstractObjectiveTo observe the local regression and control in T1 ‐2 nasopharyngeal carcinoma (NPC) patients treated with intensity‐modulated radiotherapy (IMRT) and to analyze the related influencing factors.MethodsBetween January 2006 and June 2014, 247 consecutive T1 ‐2 NPC patients treated with IMRT were retrospectively analyzed, with 126 (51.0%) N0‐1 disease and 121 (49.0%) N2‐3 disease. Among them, 72.9% received platinum‐bas...
Source: Cancer Medicine - November 8, 2018 Category: Cancer & Oncology Authors: Fen Xue, Dan Ou, Chaosu Hu, Xiayun He Tags: ORIGINAL RESEARCH Source Type: research

Combination therapy with F5/35 fiber chimeric conditionally replicative adenoviruses expressing IL ‐24 enhances the antitumor effect of temozolomide against melanoma
ConclusionsThe use of F5/35 ‐ZD55‐IL‐24 in conjunction with TMZ is a promising approach for anti‐melanoma therapy.Our results indicated that F5/35 ‐ZD55‐IL‐24 in combination with TMZ produced additive or synergistic antitumor effect and pro‐apoptotic effect in melanoma cells highly expressed CD46. The combination of F5/35‐ZD55‐IL‐24 and TMZ significantly inhibited the growth of melanoma in vivo. We also found the antitumor effect of F5/35‐ZD55‐IL‐24 was superior to ZD55‐IL‐24, the combination of F5/35‐ZD55‐IL‐24 and TMZ had a more significant antitumor effect than ZD55‐IL‐24 combin...
Source: Cancer Medicine - November 8, 2018 Category: Cancer & Oncology Authors: Ming Yang, Chunsheng Yang, Yingkai Tao, Jianqin Tang, Qian Huang, Wenwen Guo, Shouxin Feng, Aijun Jiang, Xifeng Xu, Guan Jiang, Yanqun Liu Tags: ORIGINAL RESEARCH Source Type: research

Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy
LDHA contributes to diverse bio ‐characteristics of tumors via numerous mechanisms. LDHA has been used as a tumor biomarker for clinical diagnosis and treatment and is considered as a potential anticancer target. AbstractElevated glycolysis remains a universal and primary character of cancer metabolism, which deeply depends on dysregulated metabolic enzymes. Lactate dehydrogenase A (LDHA) facilitates glycolytic process by converting pyruvate to lactate. Numerous researches demonstrate LDHA has an aberrantly high expression in multiple cancers, which is associated with malignant progression. In this review, we summarized ...
Source: Cancer Medicine - November 6, 2018 Category: Cancer & Oncology Authors: Yangbo Feng, Yanlu Xiong, Tianyun Qiao, Xiaofei Li, Lintao Jia, Yong Han Tags: REVIEW Source Type: research

Purified vitexin compound 1, a new neolignan isolated compound, promotes PUMA ‐dependent apoptosis in colorectal cancer
We demonstrated that VB1 promoted apoptosis via p53 ‐dependent induction of p53 upregulated modulator of apoptosis (PUMA) and further to induce Bax activation and mitochondrial dysfunction in colon cancer HCT‐116 and LoVo cells. And we provide a novel insight for the antitcancer mechanism of VB1 and scientific rationale for further development of VB1 as a novel anticancer drug used alone or in combination with other chemotherapeutic agents in the treatment of colorectal cancer clinically. AbstractPurified vitexin compound 1 (VB1, a neolignan isolated and extracted from the seed of Chinese herb Vitex negundo) is an effe...
Source: Cancer Medicine - November 6, 2018 Category: Cancer & Oncology Authors: Jingfei Chen, Juchang Zhong, Yeying Liu, Yuan Huang, Fei Luo, Yingjun Zhou, Xi Pan, Shousong Cao, Lingling Zhang, Yingjie Zhang, Jiangang Wang Tags: ORIGINAL RESEARCH Source Type: research

Dysregulated circular RNAs in medulloblastoma regulate proliferation and growth of tumor cells via host genes
The present study aims to investigate the expression profiles of circRNAs and related mechanisms in MB. We screened circRNAs expression profiles via HiseqTM Sequencer from four normal cerebellum and four MB samples. Subsequently, we validated expression levels of eight differential circRNAs by quantitative RT ‐PCR. Moreover, we silenced Circ‐SKA3 and Circ‐DTL with small interfere RNAs and over expressed their host genes to investigate their role in pathogenesis of medulloblastoma. The present study exploited circRNAs profiling in MB firstly and demonstrated that Circ‐SKA3 and Circ‐DTL played an important role in ...
Source: Cancer Medicine - November 6, 2018 Category: Cancer & Oncology Authors: Tao Lv, Yi ‐Feng Miao, Ke Jin, Shuo Han, Tian‐Qi Xu, Zi‐Long Qiu, Xiao‐Hua Zhang Tags: ORIGINAL RESEARCH Source Type: research

National Cancer Database report of nonmetastatic esophageal small cell carcinoma
This study of a large, contemporary national database demonstrates that most ESCC is treated with CRT in the United States; adding local therapy to systemic therapy may be beneficial to these patients, although individualized multidisciplinary manage ment is still recommended. AbstractBackgroundEsophageal small cell carcinoma (ESCC) is a rare malignancy for which there is no consensus management approach. This is the largest known analysis of nonmetastatic ESCC patients to date, evaluating national practice patterns and outcomes of surgical ‐based therapy vs chemoradiotherapy (CRT) vs chemotherapy alone.MethodsThe Nation...
Source: Cancer Medicine - November 6, 2018 Category: Cancer & Oncology Authors: Vivek Verma, Richard L. Sleightholm, Penny Fang, Jeffrey M. Ryckman, Chi Lin Tags: ORIGINAL RESEARCH Source Type: research

A real ‐world, population‐based study of patterns of referral, treatment, and outcomes for advanced pancreatic cancer
Cancer Medicine, EarlyView. (Source: Cancer Medicine)
Source: Cancer Medicine - October 31, 2018 Category: Cancer & Oncology Authors: Omar Abdel ‐Rahman, Yuan Xu, Patricia A. Tang, Richard M. Lee‐Ying, Winson Y. Cheung Source Type: research

The association of tooth loss, toothbrushing, and quality of life among cancer survivors
Cancer Medicine, EarlyView. (Source: Cancer Medicine)
Source: Cancer Medicine - October 31, 2018 Category: Cancer & Oncology Authors: Rui Yan, Xuefen Chen, Xiaohuan Gong, Jiwei Wang, Jinming Yu Source Type: research

Relationship between pretreatment concentration of plasma Epstein ‐Barr virus DNA and tumor burden in nasopharyngeal carcinoma: An updated interpretation
Cancer Medicine, EarlyView. (Source: Cancer Medicine)
Source: Cancer Medicine - October 31, 2018 Category: Cancer & Oncology Authors: Liang Peng, Yi Yang, Rui Guo, Yan ‐Ping Mao, Cheng Xu, Yu‐Pei Chen, Ying Sun, Jun Ma, Ling‐Long Tang Source Type: research

Genomewide identification of a novel six ‐LncRNA signature to improve prognosis prediction in resectable hepatocellular carcinoma
Cancer Medicine, EarlyView. (Source: Cancer Medicine)
Source: Cancer Medicine - October 31, 2018 Category: Cancer & Oncology Authors: Ying Wu, Peng ‐Shuo Wang, Ben‐Gang Wang, Lu Xu, Wan‐Xia Fang, Xiao‐Fang Che, Xiu‐Juan Qu, Yun‐Peng Liu, Zhi Li Source Type: research