Issue Information
(Source: Cancer Medicine)
Source: Cancer Medicine - April 8, 2021 Category: Cancer & Oncology Tags: ISSUE INFORMATION Source Type: research

Targeting stanniocalcin ‐1‐expressing tumor cells elicits efficient antitumor effects in a mouse model of human lung cancer
This study elucidated that STC‐1 could be useful as both a molecular target and as a marker for lung cancer. AbstractLung cancer is the most common cause of cancer ‐related death in developed countries; therefore, the generation of effective targeted therapeutic regimens is essential. Recently, gene therapy approaches toward malignant cells have emerged as attractive molecular therapeutics. Previous studies have indicated that stanniocalcin‐1 (STC‐1), a hormone involved in calcium and phosphate homeostasis, positively regulates proliferation, apoptosis resistance, and glucose metabolism in lung cancer cell lines. I...
Source: Cancer Medicine - April 8, 2021 Category: Cancer & Oncology Authors: Kotaro Abe, Masahiko Kanehira, Shinya Ohkouchi, Sakiko Kumata, Yamato Suzuki, Hisashi Oishi, Masafumi Noda, Akira Sakurada, Eisaku Miyauchi, Tohru Fujiwara, Hideo Harigae, Yoshinori Okada Tags: ORIGINAL RESEARCH Source Type: research

Effect of body mass index on pharmacokinetics of paclitaxel in patients with early breast cancer
ConclusionWhen dosed according to BSA calculated using actual body weight there is no significant difference in paclitaxel exposure between normal and overweight women. Using alternative descriptors of weight to calculate BSA could lead to under ‐dosing of this drug.Trial registrationThis study is registered in the Clinical Trials Registry of India CTRI/2015/09/006193. (Source: Cancer Medicine)
Source: Cancer Medicine - April 7, 2021 Category: Cancer & Oncology Authors: Vikram Gota, Manjunath Nookala, Avinash Bonda, Ashwin Karanam, Bharati Shriyan, Yogesh Kembhavi, Murari Gurjar, Anand Patil, Ashish Singh, Navin Goyal, Sudeep Gupta Tags: ORIGINAL RESEARCH Source Type: research

Normal tissue adjacent to tumor expression profile analysis developed and validated a prognostic model based on Hippo ‐related genes in hepatocellular carcinoma
ConclusionsWe developed and validated a prognostic model based on the expression levels of five HRGs in PNTAH, and this model should be helpful in predicting the prognosis of patients with HCC. (Source: Cancer Medicine)
Source: Cancer Medicine - April 6, 2021 Category: Cancer & Oncology Authors: Qingbo Pan, Fanbo Qin, Hanyu Yuan, Baoning He, Ni Yang, Yitong Zhang, Hong Ren, Yi Zeng Tags: ORIGINAL RESEARCH Source Type: research

Tumor genomic, transcriptomic, and immune profiling characterizes differential response to first ‐line platinum chemotherapy in high grade serous ovarian cancer
ConclusionsOur research demonstrates that tumors from HGSOC patients responding poorly to first line chemotherapy have a distinct molecular profile characterized by actionable drug targets including PARP4. (Source: Cancer Medicine)
Source: Cancer Medicine - April 3, 2021 Category: Cancer & Oncology Authors: Johanne I. Weberpals, Trevor J. Pugh, Paola Marco ‐Casanova, Glenwood D. Goss, Natalie Andrews Wright, Prisni Rath, Jonathon Torchia, Alexander Fortuna, Gemma N. Jones, Martine P. Roudier, Laurence Bernard, Bryan Lo, Dax Torti, Alberto Leon Tags: ORIGINAL RESEARCH Source Type: research

Cost ‐effectiveness analysis of primary human papillomavirus testing in cervical cancer screening: Results from the HPV FOCAL Trial
The Human Papillomavirus FOr CervicAL cancer (HPV FOCAL) trial is a large randomized controlled trial comparing primary HPV testing to liquid ‐based cytology for cervical cancer screening. We conducted a cost‐effectiveness analysis alongside the HPV FOCAL trial. Results showed the intervention group yielded a higher rate of detected cervical intraepithelial neoplasia of grade 2 or worse lesions (CIN2+) at a lower mean cost per CIN2+ d etected ($7551) than the control group ($8325), a difference of −$773. Findings suggest that primary HPV testing is cost‐effective compared to liquid‐based cytology. AbstractThe...
Source: Cancer Medicine - April 3, 2021 Category: Cancer & Oncology Authors: Ian Cromwell, Laurie W. Smith, Kim Hoek, Lindsay Hedden, Andrew J. Coldman, Darrel Cook, Eduardo L. Franco, Mel Krajden, Ruth Martin, Marette H. Lee, Gavin Stuart, Dirk Niekerk, Gina Ogilvie, Stuart Peacock Tags: ORIGINAL RESEARCH Source Type: research

Phase 1b study of galunisertib and ramucirumab in patients with advanced hepatocellular carcinoma
ConclusionCombination therapy was safe and tolerable and displayed favorable PK. The MTD was established at galunisertib at 150  mg orally twice a day and ramucirumab 8 mg/kg intravenously every 2 weeks. The results do not support the preclinical hypothesis that blocking TGFβ signaling enhances efficacy of VEGF‐targeted therapy; thus further clinical development was halted for the combination of galunisertib and ramuci rumab. (Source: Cancer Medicine)
Source: Cancer Medicine - April 3, 2021 Category: Cancer & Oncology Authors: James J. Harding, Richard K. Do, Amin Yaqubie, Ann Cleverly, Yumin Zhao, Ivelina Gueorguieva, Michael Lahn, Karim A. Benhadji, Robin K. Kelley, Ghassan K. Abou ‐Alfa Tags: ORIGINAL RESEARCH Source Type: research

Application of low ‐dose CT to the creation of 3D‐printed kidney and perinephric tissue models for laparoscopic nephrectomy
ConclusionLow ‐dose CT technology can be effectively applied to 3D printing of kidney and perinephric fat and reduce the patient's radiation dose without compromising 3D printing quality. 3D printing of kidney and perinephric fat can significantly increase the success rate of LPN and decrease OT, WIT, and EBL. (Source: Cancer Medicine)
Source: Cancer Medicine - April 2, 2021 Category: Cancer & Oncology Authors: Guan Li, Jie Dong, Zhiqiang Cao, Jinbao Wang, Dongbing Cao, Xin Zhang, Longjiang Zhang, Guangming Lu Tags: ORIGINAL RESEARCH Source Type: research

The impact of primary tumor sidedness on survival in early ‐onset colorectal cancer by stage: A National Veterans Affairs retrospective analysis
In EOCRC patients, LCC is associated with better OS than RCC only in patients with metastatic disease. In the overall population, LCC is associated with better OS in all stages except stage II, which might be due to the high incidence of MMRd tumors in this subpopulation. AbstractBackgroundThe incidence of early ‐onset colorectal cancer (EOCRC) is rising. Left‐sided colorectal cancer (LCC) is associated with better survival compared to right‐sided colon cancer (RCC) in metastatic disease. NCCN guidelines recommend the addition of EGFR inhibitors to KRAS/NRAS WT metastatic CRC originating from the left only. Whether l...
Source: Cancer Medicine - April 2, 2021 Category: Cancer & Oncology Authors: Ibrahim Azar, Nada Al Masalmeh, Saghi Esfandiarifard, Gurjiwan Virk, Wissam Kiwan, Anthony Frank Shields, Syed Mehdi, Philip A. Philip Tags: ORIGINAL RESEARCH Source Type: research

Interim and end ‐of‐treatment PET‐CT suffers from high false‐positive rates in DLBCL: Biopsy is needed prior to treatment decisions
PET ‐CT is a valid method to find DLBCL patient with insufficient treatment response but suffers from high false positive rates. Biopsy is needed before treatment decisions in PET positive patients. AbstractThe application of positron emission tomography (PET) ‐computed tomography (CT) in treatment response evaluation has increased in diffuse large B‐cell lymphoma (DLBCL), although its predictive value is controversial. We retrospectively analyzed the rate of false‐positive PET‐CTs performed as interim (n = 94) and end‐of‐treatment (n = 8) assessments among 102 DLBCL patients treated durin...
Source: Cancer Medicine - April 1, 2021 Category: Cancer & Oncology Authors: Susanna Tokola, Hanne Kuitunen, Taina Turpeenniemi ‐Hujanen, Outi Kuittinen Tags: ORIGINAL RESEARCH Source Type: research

Nitidine chloride suppresses epithelial ‐mesenchymal transition and stem cell‐like properties in glioblastoma by regulating JAK2/STAT3 signaling
NC can inhibit the EMT process and glioma stem cell characteristics of glioma cells via modulation of JAK2/STAT3 signaling, suggesting that NC may be a potential anti ‐glioma drug. AbstractGlioblastoma is the most aggressive and common intracranial malignant tumor, and the prognosis is still poor after various treatments. Based on the poor prognosis of glioma, new drugs that suppress the rapid progression and aggressive growth of glioma are urgently needed. It has been reported that nitidine chloride (NC) can inhibit tumor growth and epithelial ‐mesenchymal transition (EMT), and EMT is associated with cancer stem cell ...
Source: Cancer Medicine - April 1, 2021 Category: Cancer & Oncology Authors: Mingbo Jia, Ying Wang, Yingxue Guo, Pengyue Yu, Ying Sun, Yanke Song, Liyan Zhao Tags: ORIGINAL RESEARCH Source Type: research

Elevated TAB182 enhances the radioresistance of esophageal squamous cell carcinoma through G2 ‐M checkpoint modulation
ConclusionTAB182 potentiates the radioresistance of ESCC cells by modulating the G2 ‐M checkpoint through its interaction with FHL2. Thus, TAB182 may become an ideal biomarker and therapeutic target of ESCC radiotherapy. (Source: Cancer Medicine)
Source: Cancer Medicine - March 31, 2021 Category: Cancer & Oncology Authors: Yuandong Cao, Aidi Gao, Xiaoqing Li, Han Min, Chao He, Xinchen Sun, Wei ‐Qun Ding, Jundong Zhou Tags: ORIGINAL RESEARCH Source Type: research

Phase I study of ADI ‐PEG20 plus low‐dose cytarabine for the treatment of acute myeloid leukemia
Combination of ADI ‐PEG20 at 36 mg/m2 with LDC is tolerable with acceptable toxicities in relapsed/refractory or poor‐risk acute myeloid leukemia and induced an overall response rate of 44.4% and a median overall survival of 8.0 months, The overall response rate and complete remission rate are 71.4% and CR of 57.1 %, respectively, in treatment‐naive patients. This regimen suggests the synergistic effect of the combination of ADI‐PEG20 and chemotherapy and is warranted for further study. AbstractMost acute myeloid leukemia (AML) cells are argininosuccinate synthetase ‐deficient. Pegylated arginine deiminase (ADI...
Source: Cancer Medicine - March 31, 2021 Category: Cancer & Oncology Authors: Hui ‐Jen Tsai, Hui‐Hua Hsiao, Ya‐Ting Hsu, Yi‐Chang Liu, Hsiao‐Wen Kao, Ta‐Chih Liu, Shih‐Feng Cho, Xiaoxing Feng, Amanda Johnston, John S. Bomalaski, Ming‐Chung Kuo, Tsai‐Yun Chen Tags: RESEARCH ARTICLE Source Type: research

Growth and differentiation factor 15 and NF ‐κB expression in benign prostatic biopsies and risk of subsequent prostate cancer detection
In benign prostate biopsies we found expression of GDF ‐15 and NF‐κB were positively correlated and lower in African American compared with white men. Prostate cancer risk estimates, however, suggest that NF‐κB and GDF‐15 expression exert opposite effects on prostate tumor development. ABSTRACTGrowth and differentiation factor 15 (GDF ‐15), also known as macrophage inhibitory cytokine 1 (MIC‐1), may act as both a tumor suppressor and promotor and, by regulating NF‐κB and macrophage signaling, promote early prostate carcinogenesis. To determine whether expression of these two inflammation‐r...
Source: Cancer Medicine - March 30, 2021 Category: Cancer & Oncology Authors: Benjamin A. Rybicki, Sudha M. Sadasivan, Yalei Chen, Oleksandr Kravtsov, Watchareepohn Palangmonthip, Kanika Arora, Nilesh S. Gupta, Sean Williamson, Kevin Bobbitt, Dhananjay A. Chitale, Deliang Tang, Andrew G. Rundle, Kenneth A. Iczkowski Tags: ORIGINAL RESEARCH Source Type: research

Disparities in male versus female oncologic outcomes following bladder preservation: A population ‐based cohort study
This study examines survival following TMT of women compared with men in a population ‐based analysis. ABSTRACTIntroductionIn surgical series of muscle ‐invasive bladder cancer (MIBC), women have higher recurrence rates, disease progression, and mortality following radical cystectomy than men. Similar reports of oncologic differences between men and women following trimodality therapy (TMT) are rare. Our hypothesis was that there would be no diff erence in overall survival (OS) between sexes receiving TMT.MethodsWe queried the National Cancer Database (NCDB) for patients diagnosed with clinical stage T2 ‐T4aN0 M...
Source: Cancer Medicine - March 30, 2021 Category: Cancer & Oncology Authors: Leslie K. Ballas, Stephanie Navarro, Chunqiao Luo, Croix C. Fossum, Albert Farias, Siamak Daneshmand, Susan Groshen Tags: ORIGINAL RESEARCH Source Type: research

Impact of meningioma surgery on use of antiepileptic, antidepressant, and sedative drugs: A Swedish nationwide matched cohort study
By coupling a nationwide cancer registry of 2070 patients with data on purchased drugs and diagnoses, it was shown that after meningioma surgery the use of antiepileptics, antidepressants and sedatives was distinctly increased compared to controls. As this may be an often ‐overlooked factor in deciding whether to perform surgery, predictors for identifying especially vulnerable patients are explored. AbstractBackgroundMeningioma is the most common primary intracranial tumor and surgery is the main treatment modality. As death from lack of tumor control is rare, other outcome measures like anxiety, depression and post ‐...
Source: Cancer Medicine - March 27, 2021 Category: Cancer & Oncology Authors: Erik Thurin, Isabelle Ryd én, Thomas Skoglund, Anja Smits, Sasha Gulati, Göran Hesselager, Jiri Bartek, Roger Henriksson, Øyvind Salvesen, Asgeir S. Jakola Tags: ORIGINAL RESEARCH Source Type: research

Cytolytic activity score as a biomarker for antitumor immunity and clinical outcome in patients with gastric cancer
ConclusionThe CYT score reflects antitumor immunity and predicts clinical outcome in GC patients. (Source: Cancer Medicine)
Source: Cancer Medicine - March 26, 2021 Category: Cancer & Oncology Authors: Qingjiang Hu, Kentaro Nonaka, Hiroaki Wakiyama, Yu Miyashita, Yoshiaki Fujimoto, Tomoko Jogo, Kentaro Hokonohara, Ryota Nakanishi, Yuichi Hisamatsu, Koji Ando, Yasue Kimura, Takaaki Masuda, Eiji Oki, Koshi Mimori, Yoshinao Oda, Masaki Mori Tags: ORIGINAL RESEARCH Source Type: research

The gray zone of thyroid nodules: Using a nomogram to provide malignancy risk assessment and guide patient management
ConclusionsWe report a model for risk assessment of thyroid nodules that has the potential to significantly reduce indeterminates and surgical overtreatment. We illustrate its application via a straightforward nomogram, which integrates clinical, ultrasonographic, and cytologic data, and can be used to create clear, evidence ‐based management plans for patients. (Source: Cancer Medicine)
Source: Cancer Medicine - March 25, 2021 Category: Cancer & Oncology Authors: Elham Yousefi, Gloria H. Sura, Jonathan Somma Tags: ORIGINAL RESEARCH Source Type: research

A systematic review and meta ‐analysis of the prognostic role of age in oral tongue cancer
Although oral tongue cancer is generally considered to affect older patients, increasing evidence suggests an increasing incidence in younger patients. The study results illustrated that age at diagnosis had varying effects on the risks of poor outcomes and local recurrence. We suggest that younger patients with oral tongue cancer should receive personalized follow ‐up plans to improve prognosis by identifying disease recurrence at an early stage. AbstractWhile evidence suggests an increasing incidence of tongue cancer in young adults, published findings regarding the prognostic role of age at diagnosis are inconsistent....
Source: Cancer Medicine - March 24, 2021 Category: Cancer & Oncology Authors: Marta Tagliabue, Pietro Belloni, Rita De Berardinis, Sara Gandini, Francesco Chu, Stefano Zorzi, Caterina Fumagalli, Luigi Santoro, Susanna Chiocca, Mohssen Ansarin Tags: REVIEW Source Type: research

A machine learning ‐based survival prediction model of high grade glioma by integration of clinical and dose‐volume histogram parameters
ConclusionThe machine learning ‐based RSF model integrating both clinical and DVH variables is an improved and useful tool for predicting the survival of HGG patients. (Source: Cancer Medicine)
Source: Cancer Medicine - March 24, 2021 Category: Cancer & Oncology Authors: Haiyan Chen, Chao Li, Lin Zheng, Wei Lu, Yanlin Li, Qichun Wei Tags: ORIGINAL RESEARCH Source Type: research

Evaluating palliative opportunities in pediatric patients with leukemia and lymphoma
ConclusionPatients with hematologic malignancies experience many opportunities warranting PC support. Identifying opportunities for ideal timing of PC involvement may benefit patients with hematologic cancers and their caregivers. (Source: Cancer Medicine)
Source: Cancer Medicine - March 23, 2021 Category: Cancer & Oncology Authors: Emily J. Labudde, Nicholas P. DeGroote, Susie Smith, Jonathan Ebelhar, Kristen E. Allen, Sharon M. Castellino, Karen Wasilewski ‐Masker, Katharine E. Brock Tags: ORIGINAL RESEARCH Source Type: research

Identification of an individualized RNA binding protein ‐based prognostic signature for diffuse large B‐cell lymphoma
We found that six RNA binding proteins are significantly related to the overall survival of diffuse large B ‐cell lymphoma (DLBCL) patients, which could potentially be served as prognostic biomarkers. Gene Set Enrichment Analysis provided insight into the underlying mechanisms in the occurrence and development of DLBCL, which laid the foundation for further basic studies. AbstractRNA binding proteins (RBPs) are increasingly appreciated as being essential for normal hematopoiesis and have a critical role in the progression of hematological malignancies. However, their functional consequences and clinical significance in d...
Source: Cancer Medicine - March 22, 2021 Category: Cancer & Oncology Authors: Yongzhi Xie, Ximei Luo, Haiqing He, Tao Pan, Yizi He Tags: ORIGINAL RESEARCH Source Type: research

Symptom clusters experienced by breast cancer patients at various treatment stages: A systematic review
AbstractBreast cancer patients often experience symptoms that adversely affect their quality of life. It is understood that many of these symptoms tend to cluster together: while they might have different manifestations and occur during different phases of the disease trajectory, the symptoms often have a common aetiology that is a potential target for intervention. Understanding the symptom clusters associated with breast cancer might usefully inform the development of effective care plans for affected patients. The aim of this paper is to provide an updated systematic review of the known symptom clusters among breast can...
Source: Cancer Medicine - March 22, 2021 Category: Cancer & Oncology Authors: Winnie K. W. So, Bernard M. H. Law, Marques S. N. Ng, Xiaole He, Dorothy N. S. Chan, Carmen W. H. Chan, Alexandra L. McCarthy Tags: REVIEW Source Type: research

Estimated annual prevalence, medical service utilization and direct costs of lung cancer in urban China
ConclusionLung cancer imposed a significant economic burden on China's health system and a financial cost on lung cancer sufferers and their families. Specific policies are required to efficiently allocate health resources, contain health expenditure and decrease the individual financial burden of lung cancer. (Source: Cancer Medicine)
Source: Cancer Medicine - March 22, 2021 Category: Cancer & Oncology Authors: Dawei Zhu, Xuefeng Shi, Stephen Nicholas, Yong Ma, Ping He Tags: ORIGINAL RESEARCH Source Type: research

Issue Information
(Source: Cancer Medicine)
Source: Cancer Medicine - March 22, 2021 Category: Cancer & Oncology Tags: ISSUE INFORMATION Source Type: research

Primary care and pulmonary physicians ’ knowledge and practice concerning screening for lung cancer in Lebanon, a middle‐income country
ConclusionPCPs and pulmonary specialists are initiating discussions and ordering LDCT for lung cancer screening. However, a significant proportion of both specialties are still using a non ‐recommended screening tool (chest x‐ray); only few PCPs and pulmonary specialists recognized the population at risk for which screening is recommended. Targeted provider education is needed to close the knowledge gap and promote proper implementation of guidelines for lung cancer screening. (Source: Cancer Medicine)
Source: Cancer Medicine - March 20, 2021 Category: Cancer & Oncology Authors: Imad Bou Akl, Nathalie K. Zgheib, Maroun Matar, Deborah Mukherji, Marco Bardus, Rihab Nasr Tags: ORIGINAL RESEARCH Source Type: research

Protein disulphide isomerase inhibition as a potential cancer therapeutic strategy
Protein disulphide isomerases (PDIs) play a vital role in folding proteins into their correct comformation. Inhibition of PDIs can cause ER ‐stress leading to cellular apoptosis. In many cancers, PDI expression and activity is increased suggesting they are potential targets for novel therapies. Here we review the latest on PDI in cancer and highlight key PDI inhibitors that may be in the future used as cancer treatments. AbstractThe protein disulphide isomerase (PDI) gene family is a large, diverse group of enzymes recognised for their roles in disulphide bond formation within the endoplasmic reticulum (ER). PDI therefor...
Source: Cancer Medicine - March 20, 2021 Category: Cancer & Oncology Authors: Lauren E. Powell, Paul A. Foster Tags: REVIEW Source Type: research

Identification of MEG8/miR ‐378d/SOBP axis as a novel regulatory network and associated with immune infiltrates in ovarian carcinoma by integrated bioinformatics analysis
ConclusionsOur study establishes a novel MEG8/miR ‐378d/SOBP axis in the development and prognosis of OC, and the triple subnetwork probably affects the progression of the OC by regulating the cytokines pathway. (Source: Cancer Medicine)
Source: Cancer Medicine - March 20, 2021 Category: Cancer & Oncology Authors: Jian Lei, Zhen ‐Yu He, Jun Wang, Min Hu, Ping Zhou, Chen‐Lu Lian, Li Hua, San‐Gang Wu, Juan Zhou Tags: ORIGINAL RESEARCH Source Type: research

Blinatumomab as first salvage versus second or later salvage in adults with relapsed/refractory B ‐cell precursor acute lymphoblastic leukemia: Results of a pooled analysis
This pooled analysis of three clinical studies assessed the efficacy and safety of blinatumomab as first salvage versus second or later salvage in patients with relapsed or refractory (r/r) B ‐cell precursor (BCP) acute lymphoblastic leukemia (ALL). Compared with patients who received blinatumomab as second or later salvage, those who received blinatumomab as first salvage had a longer median overall survival, relapse‐free survival, and higher rates of remission, minimal residual dis ease response, and allogeneic hematopoietic stem cell transplant (alloHSCT) realization. Overall, blinatumomab was beneficial as first sa...
Source: Cancer Medicine - March 18, 2021 Category: Cancer & Oncology Authors: Max S. Topp, Anthony S. Stein, Nicola G ökbuget, Heinz‐August Horst, Nicolas Boissel, Giovanni Martinelli, Hagop Kantarjian, Monika Brüggemann, Yuqi Chen, Gerhard Zugmaier Tags: ORIGINAL RESEARCH Source Type: research

Disparate outcomes in nonsmall cell lung cancer by immigration status
AbstractObjectiveThe purpose of this study was to evaluate overall survival (OS) outcomes by race, stratified by country of origin in patients diagnosed with NSCLC in California.MethodsWe performed a retrospective analysis of nonsmall cell lung cancer (NSCLC) patients diagnosed between 2000 and 2012. Race/ethnicity was defined as White (W), Black (B), Hispanic (H), and Asian (A) and stratified by country of origin (US vs. non ‐US [NUS]) creating the following patient cohorts: W‐US, W‐NUS, B‐US, B‐NUS, H‐US, H‐NUS, A‐US, and A‐NUS. Three multivariate models were created: model 1 adjusted for age, gender, s...
Source: Cancer Medicine - March 18, 2021 Category: Cancer & Oncology Authors: Brittney Chau, Philip HG Ituarte, Ashwin Shinde, Richard Li, Jessica Vazquez, Scott Glaser, Erminia Massarelli, Ravi Salgia, Loretta Erhunmwunsee, Kimlin Ashing, Arya Amini Tags: ORIGINAL RESEARCH Source Type: research

Overall survival, adverse events, and economic burden in patients with chronic lymphocytic leukemia receiving systemic therapy: Real ‐world evidence from the medicare population
ConclusionOver two ‐thirds of patients survived at least 2 years after starting their first observed therapy for CLL. Our findings highlight considerable susceptibility to AEs and unmet medical need in Medicare patients with CLL treated in routine practice. Medicare incurred substantial economic burden following in itiation of systemic therapy, and patients with greater numbers of AEs accounted disproportionately for the high overall cost of CLL management. (Source: Cancer Medicine)
Source: Cancer Medicine - March 18, 2021 Category: Cancer & Oncology Authors: Ravi K. Goyal, Saurabh P. Nagar, Shaum M. Kabadi, Hannah Le, Keith L. Davis, James A. Kaye Tags: ORIGINAL RESEARCH Source Type: research

XRCC5/6 polymorphisms and their interactions with smoking, alcohol consumption, and sleep satisfaction in breast cancer risk: A Chinese multi ‐center study
ConclusionXRCC5 rs16855458 was associated with breast cancer risk, andXRCC6 rs2267437 was associated with the risk of ER −/PR− breast cancer. Breast cancer risk associated withXRCC5 andXRCC6 polymorphisms might vary according to alcohol consumption and sleep satisfaction, respectively, and merit further investigation. (Source: Cancer Medicine)
Source: Cancer Medicine - March 18, 2021 Category: Cancer & Oncology Authors: Li ‐Xiang Yu, Li‐Yuan Liu, Yu‐Juan Xiang, Fei Wang, Fei Zhou, Shu‐Ya Huang, Chao Zheng, Chun‐Miao Ye, Wen‐Zhong Zhou, Geng‐Shen Yin, Jia‐Lin Zhang, Shu‐De Cui, Fu‐Guo Tian, Zhi‐Min Fan, Cui‐Zhi Geng, Xu‐Chen Cao, Tags: ORIGINAL RESEARCH Source Type: research

MX2 mediates establishment of interferon response profile, regulates XAF1, and can sensitize melanoma cells to targeted therapy
MX2 upregulation establishes an interferon ‐induced transcriptional profile in melanoma cells. MX2 regulates tumor suppressor XAF1 and sensitizes melanoma cells to targeted therapy drugs such as vemurafenib and trametinib. AbstractMX2 is an interferon inducible gene that is mostly known for its antiviral activity. We have previously demonstrated thatMX2 is also associated with the tumorigenesis process in melanoma. However, it remains unknown which molecular mechanisms are regulated byMX2 in response to interferon signaling in this disease. Here, we report that MX2 is necessary for the establishment of an interferon ‐i...
Source: Cancer Medicine - March 18, 2021 Category: Cancer & Oncology Authors: Marina Juraleviciute, J érémie Nsengimana, Julia Newton‐Bishop, Gert J. Hendriks, Ana Slipicevic Tags: ORIGINAL RESEARCH Source Type: research

Prognostic significance of poorly differentiated histology and impact of adjuvant chemotherapy in early squamous cell carcinoma of cervix uteri
ConclusionsThe addition of cisplatin ‐based chemotherapy following surgery significantly improved recurrence‐free survival for low‐risk, poor differentiation, and early stage squamous cervical cancer patients. (Source: Cancer Medicine)
Source: Cancer Medicine - March 18, 2021 Category: Cancer & Oncology Authors: Hui Luo, Hongxia Yao, Xinxin Xu, Zhen Li, Hongqin Zhao, Haiyan Zhu Tags: ORIGINAL RESEARCH Source Type: research

Epidemiological characteristics and forecasting incidence for patients with breast cancer in Shantou, Southern China: 2006 –2017
This study aimed to explore the epidemiological characteristics of breast cancer and establish an Exponential Smoothing (ETS) and Autoregressive Integrated Moving Average (ARIMA) models to predict the development of incidence in Shantou. This study has a large sample size, strong representativeness, and wide ‐ranging and comprehensive medical insurance information, which can fill the gaps in basic epidemiological research on breast cancer in Shantou. Successful completion of this study is a helpful tool to understand the epidemiology of Guangdong Province and Southern China. This study also provides d ata and scientific ...
Source: Cancer Medicine - March 17, 2021 Category: Cancer & Oncology Authors: Huang Lin, Lei Shi, Jiachi Zhang, Jinchan Zhang, Chichen Zhang Tags: ORIGINAL RESEARCH Source Type: research

Evaluation of the modified immune prognostic index to prognosticate outcomes in metastatic uveal melanoma patients treated with immune checkpoint inhibitors
ConclusionsThe modified IPI may be a useful tool in clinical practice for identifying MUM patients who are more likely to experience irAEs and realize a survival benefit from ICI treatment. (Source: Cancer Medicine)
Source: Cancer Medicine - March 16, 2021 Category: Cancer & Oncology Authors: Michael S. Sander, Igor Stukalin, Isabelle A. Vallerand, Siddhartha Goutam, Benjamin W. Ewanchuk, Daniel E. Meyers, Aliyah Pabani, Don G. Morris, Daniel Y. C. Heng, Tina Cheng Tags: ORIGINAL RESEARCH Source Type: research

Characteristics and risk differences of different tumor size on localized prostate cancer: A retrospective cohort study in the SEER database
We quantified the relationship between tumor size and localized prostate cancer grade, and hoped to play a positive role in early diagnosis and treatment of clinical work. AbstractObjectiveWe aimed to evaluate the role of tumor size in predicting tumor risk for localized prostate cancer (PCa) patients undergoing radical prostatectomy (RP).MethodsTwenty ‐five thousand, one hundred twenty‐seven men with PCa receiving RP from 2010 to 2015 were extracted from the Surveillance, Epidemiology, and End Results database. Kaplan–Meier plots and multivariable Cox regression analyses were used to illustrate overall survival ...
Source: Cancer Medicine - March 16, 2021 Category: Cancer & Oncology Authors: Zhen Zhou, Feng Yue, Liang Jin, Xiang Liu, Ting ‐Shuai Zhai, Jia‐Xin Zhang, Wen‐Yu Gu, Sheng‐Hua Liu, Ming Luo, Bo Peng, Xu‐Dong Yao, Lin Ye Tags: ORIGINAL RESEARCH Source Type: research

Time trends of major cancers incidence and mortality in Guangzhou, China 2004 –2015: A Joinpoint and Age–Period–Cohort Analysis
ConclusionsCancer burden remained a public health challenge in Guangzhou as the aging population and lifestyles changes, despite declines in incidence and mortality rates in some cancers. Surveillance of cancer trends contributed to valuable insights into cancer prevention and control. (Source: Cancer Medicine)
Source: Cancer Medicine - March 16, 2021 Category: Cancer & Oncology Authors: Ao Luo, Hang Dong, Xiao Lin, Yu Liao, Binglun Liang, Long Chen, Guozhen Lin, Yuantao Hao Tags: ORIGINAL RESEARCH Source Type: research

Interphase fluorescence in situ hybridization analysis of CD19 ‐selected cells: Utility in detecting disease in post‐therapy samples of B‐cell neoplasms
A systematic comparison of CD19 ‐selected (CD19S) FISH versus non‐selected FISH analysis establishes superiority (qualitative and quantitative) of the former modality in detecting post‐therapy persistence or relapse of B‐cell neoplasms. CD19S FISH can complement flow cytometric evaluation for the detection of low‐level i nvolvement in B‐cell neoplasms and particularly in the detection of post‐therapy recurrent/emerging small subclones. Flow cytometry detection of
Source: Cancer Medicine - March 16, 2021 Category: Cancer & Oncology Authors: Andrew M. Parrott, Vundavalli V. Murty, Caitlin Walsh, Alecia Christiano, Govind Bhagat, Bachir Alobeid Tags: ORIGINAL RESEARCH Source Type: research

Characterization of genetics in patients with mucosal melanoma treated with immune checkpoint blockade
This study examines the genetic changes within mucosal melanoma to look for patterns that may help predict who will respond well to immunotherapy and who will not respond. Some interesting trends were observed but more work is needed to determine genetic mutations in mucosal melanoma that are associated with treatment. AbstractMucosal melanoma is a rare form of melanoma which arises from melanocytes in the mucosal membranes and can be effectively treated with immune checkpoint blockade (ICB). However, response rates in mucosal melanoma are lower than those observed for cutaneous melanomas.Targeted sequencing of up to 447 g...
Source: Cancer Medicine - March 16, 2021 Category: Cancer & Oncology Authors: Elizabeth I. Buchbinder, Jason L. Weirather, Michael Manos, Brian J. Quattrochi, Lynette M. Sholl, Ryan C. Brennick, Peter Bowling, Nancy Bailey, Lisa Magarace, Patrick A. Ott, Rizwan Haq, Benjamin Izar, Anita Giobbie ‐Hurder, F. Stephen Ho Tags: ORIGINAL RESEARCH Source Type: research

Issue Information
(Source: Cancer Medicine)
Source: Cancer Medicine - March 15, 2021 Category: Cancer & Oncology Tags: ISSUE INFORMATION Source Type: research

Systemic therapies in advanced epithelioid haemangioendothelioma: A retrospective international case series from the World Sarcoma Network and a review of literature
ConclusionSystemic therapies available for advanced sarcomas have limited activity in EHE. The identification of new active compounds, especially for rapidly progressive cases, is acutely needed. (Source: Cancer Medicine)
Source: Cancer Medicine - March 13, 2021 Category: Cancer & Oncology Authors: Anna M. Frezza, Vinod Ravi, Salvatore Lo Vullo, Bruno Vincenzi, Francesco Tolomeo, Tom Wei ‐Wu Chen, Pawel Teterycz, Giacomo G. Baldi, Antoine Italiano, Nicolas Penel, Antonella Brunello, Florance Duffaud, Nadia Hindi, Shintaro Iwata, Alan Tags: ORIGINAL RESEARCH Source Type: research

Integrative analysis regarding the correlation between GAS2 family genes and human glioma prognosis
Compared withGAS2,GAS2L1, andGAS2L2, there is a stronger correlation betweenGAS2L3 gene expression and glioma prognosis. DNA hypomethylation ofGAS2L3 may contribute to the high expression level ofGAS2L3 and the poor clinical prognosis of glioma.GAS2L3 gene is capable of influencing the proliferation and migration ability of glioma cells and may be linked to a series of immune cell infiltration or cell division ‐associated events in the etiology and biology of glioma. AbstractBackgroundEmerging oncogenes were reportedly linked to the complicated subtypes and pathogenesis of clinical gliomas. Herein, we first comprehensive...
Source: Cancer Medicine - March 13, 2021 Category: Cancer & Oncology Authors: Chunyan Zhao, Nan Zhang, Xiaoteng Cui, Xinxin Zhang, Yuanyuan Ren, Chao Su, Jinyan He, Wei Zhang, Xiaoming Sun, Jie Yang, Xingjie Gao Tags: ORIGINAL RESEARCH Source Type: research

Population ‐based analysis of perioperative chemotherapy use, interventions requiring hospitalization and atheroembolic events among patients with non‐metastatic muscle‐invasive bladder cancer
In the Province of Ontario, trends suggest an increase in the adoption of neoadjuvant chemotherapy from 3% in 2002 to 35% in 2015 (p 
Source: Cancer Medicine - March 12, 2021 Category: Cancer & Oncology Authors: Tarik Benidir, Jaime Herrera ‐Caceres, Christopher Wallis, Katherine Lajkosz, Neil Fleshner Tags: ORIGINAL RESEARCH Source Type: research

Knockout of vasohibin ‐2 reduces tubulin carboxypeptidase activity and increases paclitaxel sensitivity in ovarian cancer
In the present study, we demonstrated that the knockout of the angiogenesis stimulator, vasohibin ‐2 (VASH2) reduced tubulin carboxypeptidase (TCP) activity, increased cyclin B1 expression, and increased paclitaxel chemosensitivity in ovarian cancer cells. The inhibition of angiogenesis and regulation of microtubule activity may be expected in ovarian cancer treatment strategies targeting VASH 2. AbstractVasohibin ‐1 (VASH1) is a VEGF‐inducible endothelium‐derived angiogenesis inhibitor, and vasohibin‐2 (VASH2), its homolog, exhibits proangiogenic activity. VASH2 is expressed by various cancer cells and accelerat...
Source: Cancer Medicine - March 12, 2021 Category: Cancer & Oncology Authors: Takahiro Koyanagi, Yasushi Saga, Yoshifumi Takahashi, Kohei Tamura, Takahiro Yoshiba, Suzuyo Takahashi, Akiyo Taneichi, Yuji Takei, Masashi Urabe, Hiroaki Mizukami, Hiroyuki Fujiwara Tags: ORIGINAL RESEARCH Source Type: research

Waist circumference and a body shape index and prostate cancer risk and mortality
This study provides a more complete picture of the association between abdominal adiposity and the risk of prostate cancer and the mortality associated with it. The findings support a prevailing, yet poorly tested, hypothesis that the negative association between waist circumference and the risk of localised prostate cancer may be partly driven by normal ‐weight men undergoing prostate cancer screening more often than obese men. The negative association between waist circumference and the risk of localised prostate cancer is partially driven by asymptomatic prostate cancer’s detected through a prostate‐specific a...
Source: Cancer Medicine - March 12, 2021 Category: Cancer & Oncology Authors: Sylvia H. J. Jochems, Angela M. Wood, Christel H äggström, Marju Orho‐Melander, Pär Stattin, Tanja Stocks Tags: ORIGINAL RESEARCH Source Type: research

Consistency of the S5 DNA methylation classifier in formalin ‐fixed biopsies versus corresponding exfoliated cells for the detection of pre‐cancerous cervical lesions
In this study, we establish that the S5 Classifier works to a similar level of sensitivity and specificity in FFPE tissue as it does in ex foliated samples and with three other bisulfite conversion kits. This validates its validity as an effective biomarker assay. AbstractMethylation biomarkers are promising tools for diagnosis and disease prevention. The S5 classifier is aimed at the prevention of cervical cancer by the early detection of cervical intraepithelial neoplasia (CIN). S5 is based on pyrosequencing a promoter region ofEPB41L3 and five late regions of HPV types 16, 18, 31, and 33 following bisulfite conversion o...
Source: Cancer Medicine - March 12, 2021 Category: Cancer & Oncology Authors: Caroline Reuter, Matthew Preece, Rawinder Banwait, Sabrina Boer, Jack Cuzick, Attila Lorincz, Belinda Nedjai Tags: ORIGINAL RESEARCH Source Type: research

Screening for cancers with a good prognosis: The case of testicular germ cell cancer
ConclusionDespite the good prognosis, self ‐examination at young ages for testicular germ cell cancer could be considered. (Source: Cancer Medicine)
Source: Cancer Medicine - March 12, 2021 Category: Cancer & Oncology Authors: Eveline A. M. Heijnsdijk, Steven J. Supit, Leendert H. J. Looijenga, Harry J. Koning Tags: ORIGINAL RESEARCH Source Type: research

Machine learning for the prediction of bone metastasis in patients with newly diagnosed thyroid cancer
ConclusionsThe RF model constructed in this study could accurately predict bone metastases in TC patients, which may provide clinicians with more personalized clinical decision ‐making recommendations. Machine learning technology has the potential to improve the development of BM prediction models in TC patients. (Source: Cancer Medicine)
Source: Cancer Medicine - March 12, 2021 Category: Cancer & Oncology Authors: Wen ‐Cai Liu, Zhi‐Qiang Li, Zhi‐Wen Luo, Wei‐Jie Liao, Zhi‐Li Liu, Jia‐Ming Liu Tags: ORIGINAL RESEARCH Source Type: research

The association of resistance training with risk of ovarian cancer
Conclusions& InferencesWe observed no evidence that moderate levels of RT were associated with risk of ovarian cancer. Further investigations are required to confirm these findings. (Source: Cancer Medicine)
Source: Cancer Medicine - March 11, 2021 Category: Cancer & Oncology Authors: Andrea L Buras, Cassandra A Hathaway, Tianyi Wang, Mary K Townsend, Shelley S Tworoger Tags: ORIGINAL RESEARCH Source Type: research