Cancer associated thrombosis and mortality in patients with cancer stratified by khorana score risk levels
This cohort study evaluated the risk of VTE and survival rates among patients newly diagnosed with cancer and stratified by Khorana score (KS) in a real ‐world population. The present findings indicate that the rates of VTE significantly increased with KS, confirming its predictive ability. Moreover, VTE was associated with lower survival rates within each KS cohort. AbstractBackgroundThe Khorana score (KS) clinical algorithm is used to predict VTE risk in cancer patients. The study objective was to evaluate VTE and survival rates among patients newly diagnosed with cancer and stratified by KS in a real ‐world populati...
Source: Cancer Medicine - September 20, 2020 Category: Cancer & Oncology Authors: Alok A. Khorana, Nicole M. Kuderer, Keith McCrae, Dejan Milentijevic, Guillaume Germain, Fran çois Laliberté, Sean D. MacKnight, Patrick Lefebvre, Gary H. Lyman, Michael B. Streiff Tags: ORIGINAL RESEARCH Source Type: research

Correlation between hematological parameters and outcome in patients with locally advanced cervical cancer treated by concomitant chemoradiotherapy
ConclusionsThis study found no association between Hb count or RBC transfusions and outcome. The daily practice of maintaining the Hb count above 12  g/dL during CCRT should be weighed against the potential risks of transfusions. Drops in WBC and PMN counts during treatment positively impacted OS and RFS and could, therefore, serve as biomarkers during CCRT to adapt the follow‐up and consider the need for adjuvant systemic treatments. (Source: Cancer Medicine)
Source: Cancer Medicine - September 20, 2020 Category: Cancer & Oncology Authors: Christine Gennigens, Marjolein De Cuypere, Laurence Seidel, Johanne Hermesse, Annelore Barbeaux, Fr édéric Forget, Adelin Albert, Guy Jerusalem, Frédéric Kridelka Tags: ORIGINAL RESEARCH Source Type: research

A risk stratification model for predicting brain metastasis and brain screening benefit in patients with metastatic triple ‐negative breast cancer
ConclusionsWe have developed a robust tool that is able to predict subsequent brain metastasis in mTNBC patients. Our model will allow selection of patients at high risk for brain metastasis who might benefit from routine bran MRI screening. (Source: Cancer Medicine)
Source: Cancer Medicine - September 18, 2020 Category: Cancer & Oncology Authors: Mingxi Lin, Yizi Jin, Jia Jin, Biyun Wang, Xichun Hu, Jian Zhang Tags: ORIGINAL RESEARCH Source Type: research

Development and validation of prognostic nomogram in patients with nonmetastatic malignant melanoma: a SEER population ‐based study
ConclusionWe constructed a novel nomogram that more accurately and comprehensively predict OS with nonmetastatic malignant melanoma patients, which is vital  for clinician to improve individual treatment, make reasonable clinical decisions, and set appropriate follow‐up strategies. (Source: Cancer Medicine)
Source: Cancer Medicine - September 17, 2020 Category: Cancer & Oncology Authors: Yu Xiao, Shanshan Peng, Youhong Hu, Jie Zhang, Xianwei Cao Tags: ORIGINAL RESEARCH Source Type: research

Adjuvant radiation therapy alone is associated with improved overall survival compared to hormonal therapy alone in older women with estrogen receptor positive early stage breast cancer
In this cohort study of 130,194 women age ≥65 years with invasive ER+, node negative breast cancer who underwent breast conserving surgery, radiation (RT) with hormonal therapy (HT) was associated with the highest 5 and 10‐year survival rates (90.0% and 64.3%, respectively). Compared to patients receiving HT alone, those receiving RT al one had improved unadjusted and adjusted survival rates. AbstractBackgroundBreast conserving surgery (BCS) and adjuvant hormonal therapy (HT) without radiation therapy (RT) is an acceptable approach for older women with early stage, estrogen receptor (ER) positive breast cancer. Toxici...
Source: Cancer Medicine - September 17, 2020 Category: Cancer & Oncology Authors: Sachin R. Jhawar, Naomi Alpert, Emanuela Taioli, Mutlay Sayan, Jose Bazan, Ko Un Park, Daniel Stover, Mathew Cherian, Julia White, Bruce Haffty, Nisha Ohri Tags: ORIGINAL RESEARCH Source Type: research

Convalescent Plasma for the Treatment of Severe COVID ‐19 Infection in Cancer Patients
ConclusionsConvalescent plasma may be a promising therapy in cancer patients with COVID ‐19. (Source: Cancer Medicine)
Source: Cancer Medicine - September 17, 2020 Category: Cancer & Oncology Authors: Douglas Tremblay, Carina Seah, Thomas Schneider, Sheena Bhalla, Jonathan Feld, Leonard Naymagon, Bo Wang, Vaibhav Patel, Tomi Jun, Thomas Jandl, Farah Rahman, Sean T. H. Liu, Judith A. Aberg, Nicole Bouvier, The Mount Sinai Health System Con Tags: ORIGINAL RESEARCH Source Type: research

Genetic variation associated with childhood and adult stature and risk of MYCN ‐amplified neuroblastoma
ConclusionsGenetic propensity to taller childhood height and shorter adult height were associated withMYCN‐amplified neuroblastoma risk, suggesting that biological pathways affecting growth trajectories and pubertal timing may contribute toMYCN‐amplified neuroblastoma etiology. (Source: Cancer Medicine)
Source: Cancer Medicine - September 17, 2020 Category: Cancer & Oncology Authors: Eleanor C. Semmes, Erica Shen, Jennifer L. Cohen, Chenan Zhang, Qingyi Wei, Jillian H. Hurst, Kyle M. Walsh Tags: ORIGINAL RESEARCH Source Type: research

Development and external validation of a nomogram to predict the risk of Upper gastrointestinal precancerous lesions in a non ‐high‐incidence area
ConclusionThe nomogram provides screening workers a simple and accurate tool for identifying individuals at a higher risk of UGPL as primary screening before endoscopy among Chinese population in non ‐high‐risk areas, thus reducing the incidence of UGC by improving the UGPL detection. (Source: Cancer Medicine)
Source: Cancer Medicine - September 16, 2020 Category: Cancer & Oncology Authors: Hai ‐Fan Xiao, Shi‐Peng Yan, Ji‐Gang Li, Zhao‐Hui Shi, Yan‐Hua Zou, Ke‐Kui Xu, Xian‐Zhen Liao Tags: ORIGINAL RESEARCH Source Type: research

Radiation therapy and secondary malignancy in Li ‐Fraumeni syndrome: A hereditary cancer registry study
ConclusionWe found that four of14 patients treated with RT developed in ‐field malignancies. All had the same histology as the primary suggesting local recurrences rather than RT‐induced malignancies. We recommend that RT should be considered as part of the treatment algorithm when clinically indicated and after multidisciplinary discussion. (Source: Cancer Medicine)
Source: Cancer Medicine - September 15, 2020 Category: Cancer & Oncology Authors: Peter G. Hendrickson, Yukun Luo, Wendy Kohlmann, Josh Schiffman, Luke Maese, Andrew J. Bishop, Shane Lloyd, Kristine E. Kokeny, Ying J. Hitchcock, Matthew M. Poppe, David K. Gaffney, Randa Tao Tags: ORIGINAL RESEARCH Source Type: research

Comparing bowel and urinary domains of patient ‐reported quality of life at the end of and 3 months post radiotherapy between intensity‐modulated radiotherapy and proton beam therapy for clinically localized prostate cancer
Prospectively ‐collected EPIC‐26 scores were analyzed to assess differences in patient‐reported outcomes in bowel and urinary domains between patients treated with intensity‐modulated radiotherapy (IMRT) and proton beam therapy (PBT) for localized prostate cancer at the end of and 3 months post‐radioth erapy at a tertiary cancer center. Patients treated with PBT had less acute decrement in the bowel function domain than those treated with IMRT; there was no difference between the two modalities in the urinary irritative/obstructive and urinary incontinence (UI) domains. AbstractPurposeTo prospectively assess...
Source: Cancer Medicine - September 15, 2020 Category: Cancer & Oncology Authors: Miao Bai, Kimberly R. Gergelis, Mustafa Sir, Thomas J. Whitaker, David M. Routman, Bradley J. Stish, Brian J. Davis, Thomas M. Pisansky, Richard Choo Tags: ORIGINAL RESEARCH Source Type: research

The clinical value and potential molecular mechanism of the downregulation of MAOA in hepatocellular carcinoma tissues
ConclusionsA decreasedMAOA level is not only correlated with aggressive behaviors in males but also serves as a promising biomarker for the diagnosis and prognosis of HCC patients. Moreover,MAOA may play a role in AFB1 toxic transformation through its synergistic action with co ‐expressed genes, especially CYP3A4.MAOA also serves as a potential therapy target of NC in HCC patients. (Source: Cancer Medicine)
Source: Cancer Medicine - September 15, 2020 Category: Cancer & Oncology Authors: Yu ‐Yan Pang, Jian‐Di Li, Li Gao, Xia Yang, Yi‐Wu Dang, Ze‐Feng Lai, Li‐Min Liu, Jie Yang, Hua‐Yu Wu, Rong‐Quan He, Zhi‐Guang Huang, Dan‐Dan Xiong, Li‐Hua Yang, Lin Shi, Wei‐Jia Mo, Deng Tang, Hui‐Ping Lu, Gang Che Tags: ORIGINAL RESEARCH Source Type: research

Covid ‐19 in patients with hematological and solid cancers at a Comprehensive Cancer Center in Germany
ConclusionsCompared to an age ‐matched noncancer cohort, we did not observe an association between a cancer diagnosis and a more severe disease course or higher fatality rate in patients with Covid‐19. Patients with a hematological malignancy showed a trend towards a longer duration until clinical improvement and longer hosp italization time compared to patients with a solid cancer. Cancer per se does not seem to be a confounder for dismal outcome in Covid‐19. (Source: Cancer Medicine)
Source: Cancer Medicine - September 15, 2020 Category: Cancer & Oncology Authors: Khalid Shoumariyeh, Francesca Biavasco, Gabriele Ihorst, Siegbert Rieg, Alexandra Nieters, Winfried V. Kern, Cornelius Miething, Justus Duyster, Monika Engelhardt, Hartmut Bertz Tags: ORIGINAL RESEARCH Source Type: research

Analysis of chemotherapy effect on the second primary malignancy for head and neck cancer patients by a nomogram based on SEER database
Second primary malignancy (SPM) ranks the second leading cause of death in patients with head and neck cancer. A conclusion was made that chemotherapy was negatively correlated with the SPM based on the comprehensive analysis of SEER database. AbstractSecond primary malignancy (SPM) ranks the second leading cause of death in patients with head and neck cancer (HNC), while studies exploring the risk factors for SPM are limited. To clarify this, we investigated the relationship between the chemotherapy and SPM using the Surveillance, Epidemiology, and End Results (SEER) database. 11  345 patients initially diagnosed wit...
Source: Cancer Medicine - September 15, 2020 Category: Cancer & Oncology Authors: Xinrong Li, Kaibo Guo, Yuqian Feng, Yong Guo Tags: ORIGINAL RESEARCH Source Type: research

Correlation of tumor ‐infiltrating immune cells of melanoma with overall survival by immunogenomic analysis
ConclusionThese results reveal the cellular and molecular characteristics of immune cells in melanoma, providing a method for selecting targets of immunotherapies and promoting the efficacy of therapies for the treatment of melanoma. (Source: Cancer Medicine)
Source: Cancer Medicine - September 15, 2020 Category: Cancer & Oncology Authors: Lili Huang, Hong Chen, Yu Xu, Jianhua Chen, Zhuqing Liu, Qing Xu Tags: ORIGINAL RESEARCH Source Type: research

Impact of complete surgical resection on outcome in aggressive non ‐Hodgkin lymphoma treated with immunochemotherapy
ConclusionYoung patients with early stage DLBCL may benefit from complete lymphoma resection prior to immunochemotherapy. (Source: Cancer Medicine)
Source: Cancer Medicine - September 14, 2020 Category: Cancer & Oncology Authors: Christine Schmitz, Jan Rekowski, Stefan P. M üller, Navid Farsijani, Bernd Hertenstein, Christiane Franzius, Ulla Verschuer, Paul La Rosée, Martin Freesmeyer, Stefan Wilop, Thomas Krohn, Aruna Raghavachar, Arnold Ganser, Frank M. Bengel, G Tags: ORIGINAL RESEARCH Source Type: research

A four ‐gene signature associated with clinical features can better predict prognosis in prostate cancer
This study is aimed to add novel biomarkers of PCa development and prognosis by analyzing the genetic changes and clinical traits comprehensively. Based on integrated analysis, four genes were significantly related to the prognosis of PCa and well validated in other datasets. Furthermore, combination of four genes and clinical features achieved a better prediction to guide the prognosis of patients with PCa. AbstractProstate cancer (PCa) is one of the most deadly urinary tumors in men globally, and the 5 ‐year over survival is poor due to metastasis of tumor. It is significant to explore potential biomarkers for early di...
Source: Cancer Medicine - September 13, 2020 Category: Cancer & Oncology Authors: Penghui Yuan, Le Ling, Qing Fan, Xintao Gao, Taotao Sun, Jianping Miao, Xianglin Yuan, Jihong Liu, Bo Liu Tags: ORIGINAL RESEARCH Source Type: research

Sarcopenia and adverse health ‐related outcomes: An umbrella review of meta‐analyses of observational studies
Conclusions and ImplicationsSarcopenia significantly affected a wide range of adverse health ‐related outcomes, particularly in patients of tumor and elderly populations. Because evidences of most outcomes were rated as “low” and “very low,” more prospective cohort studies are required in the future. (Source: Cancer Medicine)
Source: Cancer Medicine - September 13, 2020 Category: Cancer & Oncology Authors: Lin Xia, Rui Zhao, Qianyi Wan, Yutao Wu, Yong Zhou, Yong Wang, Yaping Cui, Xiaoding Shen, Xiaoting Wu Tags: ORIGINAL RESEARCH Source Type: research

Second primary breast cancer after unilateral mastectomy alone or with contralateral prophylactic mastectomy
We examine second primary breast cancer in the setting of unilateral or bilateral mastectomy using a population ‐level database. Our results show that although patients with bilateral mastectomy have reduced odds of second primary breast cancer, this must be interpreted in the context of an overall low rate of second primary breast cancer. AbstractBackgroundAn increasing number of patients undergo contralateral prophylactic mastectomy (CPM) for unilateral breast cancer. However, the benefit of CPM has not been quantified in the setting of contemporary breast cancer therapy.MethodsWe performed an analysis of 180  068...
Source: Cancer Medicine - September 12, 2020 Category: Cancer & Oncology Authors: Shailesh Agarwal, Lisa Pappas, Cindy B. Matsen, Jayant P. Agarwal Tags: ORIGINAL RESEARCH Source Type: research

LncRNA LINC00857 regulates the progression and glycolysis in ovarian cancer by modulating the Hippo signaling pathway
MiR ‐486‐5p restrains cell progression and promotes cell apoptosis in ovarian cancer. Long intergenic non‐protein coding RNA 857 accelerates ovarian cancer progression and glycolysis via regulating Yes1 associated transcriptional regulator. AbstractOvarian cancer is one of the most common gynecological cancers with high morbidity and mortality, which seriously endangers women's health and quality of life. Long noncoding RNAs (lncRNAs) can regulate the progression of cancers, including ovarian cancer. LINC00857 (long intergenic non ‐protein coding RNA 857) has been discovered to be a crucial factor in the regulation...
Source: Cancer Medicine - September 12, 2020 Category: Cancer & Oncology Authors: Xueke Lin, Dilu Feng, Ping Li, Yuchun Lv Tags: ORIGINAL RESEARCH Source Type: research

Stereotactic body radiotherapy vs conventionally fractionated chemoradiation in locally advanced pancreatic cancer: A multicenter case ‐control study (PAULA‐1)
An equivalence of stereotactic body radiotherapy (SBRT) and chemoradiation (CRT) has been only suggested in some retrospective studies in pancreatic cancer (PC). This is the first matched case ‐control study comparing SBRT and CRT in PC considering several endpoints. An equivalence in terms of overall survival, disease free survival, and metastasis free survival among the two treatments and an advantage of SBRT in terms of local control were recorded. Therefore, SBRT is almost comparabl e to standard CRT. AbstractConventionally fractionated chemoradiation (CRT) or chemotherapy (CHT) are considered as standard options in ...
Source: Cancer Medicine - September 10, 2020 Category: Cancer & Oncology Authors: Alessandra Arcelli, Milly Buwenge, Gabriella Macchia, Federica Bertini, Alessandra Guido, Francesco Deodato, Savino Cilla, Valerio Scotti, Maria Elena Rosetto, Igor Djan, Salvatore Parisi, Gian Carlo Mattiucci, Francesco Cellini, Michele Fior Tags: ORIGINAL RESEARCH Source Type: research

Simultaneous integrated boost of intensity ‐modulated radiation therapy to Stage II‐III non‐small cell lung cancer with metastatic lymph nodes
The objective response rate (ORR) was 90%, with CR 25%, PR 65%, NC 10%, and PD 0%. Although radiotherapy toxicity was common, there were no grade ≥3, w ith radiation pneumonitis (10 cases), esophagitis (17 cases), and dermatitis (12 cases). The local control rates at 1, 3, and 5 years were 85%, 75%, and 70%, respectively. The overall survival(OS)and local progression‐free survival (LPFS) rates at 1, 3, and 5 years were 90%, 42.6%, and 35.5% and 84.4%, 35.5%, and 28.4%, respectively. SIB‐IMRT can significantly improve ORR and survival for stage II‐III NSCLC with metastatic lymph nodes, with high safet...
Source: Cancer Medicine - September 9, 2020 Category: Cancer & Oncology Authors: Qing ‐Song Li, Na Liang, Wei‐Wei Ouyang, Sheng‐Fa Su, Zhu Ma, Yi‐Chao Geng, Wen‐Gang Yang, Yin‐Xiang Hu, Hui‐Qin Li, Bing Lu Tags: ORIGINAL RESEARCH Source Type: research

Develop a circular RNA –related regulatory network associated with prognosis of gastric cancer
ConclusionOur study established a circRNA ‐miRNA‐mRNA regulatory network and defined six circRNA‐related hub genes in GC, which could serve as potential therapeutic targets or prognostic biomarker for GC treatment. (Source: Cancer Medicine)
Source: Cancer Medicine - September 9, 2020 Category: Cancer & Oncology Authors: Shuxun Wei, Shifeng Teng, Jun Yao, Wenchao Gao, Jia Zang, Guangyong Wang, Zhiqian Hu Tags: ORIGINAL RESEARCH Source Type: research

Development of an IFN γ response‐related signature for predicting the survival of cutaneous melanoma
We established an effective five ‐IFNγ response‐related gene‐based risk score, which has potential to be a novel prognostic signature and may provide insight into tumor immune microenvironment of cutaneous melanoma. AbstractBackgroundThe tumor microenvironment (TME) plays a critical role in tumorigenesis, development, and therapeutic efficacy. Major advances have been achieved in the treatment of various cancers through immunotherapy. Nevertheless, only a minority of patients have positive responses to immunotherapy, which is partly due to conditions of the immunosuppressive microenvironment. Therefore, it is e...
Source: Cancer Medicine - September 9, 2020 Category: Cancer & Oncology Authors: Baohui Hu, Qian Wei, Xueping Li, Mingyi Ju, Lin Wang, Chenyi Zhou, Lianze Chen, Zinan Li, Minjie Wei, Miao He, Lin Zhao Tags: ORIGINAL RESEARCH Source Type: research

Serum N ‐Glycome analysis reveals pancreatic cancer disease signatures
ConclusionSerumN‐glycome analysis revealed glycosylation differences that allow classification of PDAC patients from healthy controls. It was demonstrated that glycosylation traits rather than singleN‐glycan structures obtained in this clinical glycomics study can serve as a basis for further development of a blood‐based diagnostic test. (Source: Cancer Medicine)
Source: Cancer Medicine - September 8, 2020 Category: Cancer & Oncology Authors: Gerda C. M. Vreeker, Randa G. Hanna ‐Sawires, Yassene Mohammed, Marco R. Bladergroen, Simone Nicolardi, Viktoria Dotz, Jan Nouta, Bert A. Bonsing, Wilma E. Mesker, Yuri E. M. Burgt, Manfred Wuhrer, Rob A. E. M. Tollenaar Tags: ORIGINAL RESEARCH Source Type: research

Prognostic significance for colorectal carcinoid tumors based on the 8th edition TNM staging system
For all carcinoid tumors, detailed 8th AJCC categories of advanced stages conferred increased HRs with overlapping CIs. However, in the early and middle status, HRs did not increase with the increase of stages, or there was no difference in HRs between adjacent stages. More optimized staging methods should be developed and validated in the future. AbstractThe aim of our study was to explore the value of the 8th edition TNM staging system on evaluating the prognosis of colorectal carcinoid. Colorectal carcinoid patients between 1988 and 2015 were selected in the Surveillance, Epidemiology, and End Results Program (SEER) dat...
Source: Cancer Medicine - September 8, 2020 Category: Cancer & Oncology Authors: Piqing Gong, Chunhua Chen, Zhan Wang, Xukun Zhang, Wenxin Hu, Zhiqian Hu, Xinxing Li Tags: ORIGINAL RESEARCH Source Type: research

Prevalence and severity of long ‐term physical, emotional, and cognitive fatigue across 15 different cancer entities
The FiX study compared fatigue in 2244 cancer patients across 15 tumor entities. Fatigue was prevalent even 2  years after diagnosis across all entities, but with different manifestation. We identified entity‐specific issues to be considered in the treatment of fatigue. AbstractBackgroundFatigue prevalence and severity have been assessed in a variety of studies, yet, not in a standardized way, and predominantly in breast cancer patients. Systematic, comparative investigations across a broad range of cancer entities are lacking.MethodsThe FiX study systematically enrolled 2244 cancer patients across 15 entities appro...
Source: Cancer Medicine - September 7, 2020 Category: Cancer & Oncology Authors: Martina E. Schmidt, Silke Hermann, Volker Arndt, Karen Steindorf Tags: ORIGINAL RESEARCH Source Type: research

Implementation of p16/Ki67 dual stain cytology in a Danish routine screening laboratory: Importance of adequate training and experience
As training and experience in p16/Ki67 dual stain interpretation may affect concordance and possibly diagnostic accuracy of cervical precancer, it is important that future studies accurately describe any training and previous experience among evaluators to allow for a meaningful comparison of dual stain accuracy across studies. Furthermore, setting up proper dual stain training programs in routine screening laboratories is advisable to ensure sufficient interpretation skills among novice evaluators. AbstractBackgroundImmunocytochemical staining with p16/Ki67 has been suggested as a promising triage biomarker in cervical ca...
Source: Cancer Medicine - September 7, 2020 Category: Cancer & Oncology Authors: Anne Hammer, Line W. Gustafson, Pia N. Christensen, Rikke Br øndum, Berit Andersen, Rikke H. Andersen, Mette Tranberg Tags: ORIGINAL RESEARCH Source Type: research

Back Cover
The cover image is based on the Original ArticleAssociation of sonographic features and molecular subtypes in predicting breast cancer disease outcomes by Haoyu Wang et al.,https://doi.org/10.1002/cam4.3305. (Source: Cancer Medicine)
Source: Cancer Medicine - September 7, 2020 Category: Cancer & Oncology Authors: Haoyu Wang, Jiejie Yao, Ying Zhu, Weiwei Zhan, Xiaosong Chen, Kunwei Shen Tags: BACK COVER Source Type: research

Front Cover
The cover image is based on the Original ArticleDNA aneuploidy with image cytometry for detecting dysplasia and carcinoma in oral potentially malignant disorders: a prospective diagnostic study by Chenxi Li et al.,https://doi.org/10.1002/cam4.3293. (Source: Cancer Medicine)
Source: Cancer Medicine - September 7, 2020 Category: Cancer & Oncology Authors: Chenxi Li, Lan Wu, Yiwen Deng, Xuemin Shen, Wei Liu, Linjun Shi Tags: FRONT COVER Source Type: research

Issue Information
Cancer Medicine, Volume 9, Issue 17, Page 6077-6078, September 2020. (Source: Cancer Medicine)
Source: Cancer Medicine - September 7, 2020 Category: Cancer & Oncology Tags: ISSUE INFORMATION Source Type: research

Local ablation vs partial nephrectomy in T1N0M0 renal cell carcinoma: An inverse probability of treatment weighting analysis
To compare the prognosis of local ablation (LA) and partial nephrectomy (PN) for T1N0M0 renal cell carcinoma (RCC) in the era of active surveillance and minimally invasive PN. Overall, PN showed a better OS and CSS than LA in T1N0M0 RCC treatment, but for elder age (>85  years), small tumors (
Source: Cancer Medicine - September 5, 2020 Category: Cancer & Oncology Authors: Lei Shi, Yan He, Chang Liu, Xiaoyuan Qian, Zhixian Wang Tags: ORIGINAL RESEARCH Source Type: research

Associations between safety, tolerability, and toxicity and the reporting of health ‐related quality of life in phase III randomized trials in common solid tumors
ConclusionsHRQoL is reported in only two ‐thirds of RCTs that describe collecting such data. Reporting of HRQoL is associated with positive trial outcome and higher journal impact factor, but not associated with overall safety and tolerability of anti‐cancer drugs. (Source: Cancer Medicine)
Source: Cancer Medicine - September 4, 2020 Category: Cancer & Oncology Authors: Ramy R. Saleh, Nicholas Meti, Domen Ribnikar, Hadar Goldvaser, Alberto Ocana, Arnoud J. Templeton, Bostjan Seruga, Eitan Amir Tags: ORIGINAL RESEARCH Source Type: research

Long noncoding RNA LINC01410 promotes the tumorigenesis of neuroblastoma cells by sponging microRNA ‐506‐3p and modulating WEE1
ConclusionsKnockdown of LINC01410 inhibited the development of NBL by miR ‐506‐3p/WEE1 axis in vitro, which could serve as a potential therapeutic target for NBL therapy. (Source: Cancer Medicine)
Source: Cancer Medicine - September 4, 2020 Category: Cancer & Oncology Authors: Jie Mi, Yang Han, Jin Zhang, Xiwei Hao, Maoqing Xing, Cong Shang Tags: ORIGINAL RESEARCH Source Type: research

Impact of radiotherapy to the primary tumor on the efficacy of pembrolizumab for patients with advanced urothelial cancer: A preliminary study
Radiotherapy to the primary tumor was significantly associated with favourable therapeutic response and prognosis following pembrolizumab therapy in advanced urothelial cancer patients. Thus, radiotherapy to the primary tumor may enhance the efficacy of pembrolizumab, indicating the possibility that radiotherapy to the primary tumor in combination with pembrolizumab may be a promising therapeutic strategy for urothelial cancer. AbstractRadiotherapy plus immune checkpoint inhibitors can potentially induce synergistic antitumor immune responses. However, little clinical evidence is established regarding their combination the...
Source: Cancer Medicine - September 4, 2020 Category: Cancer & Oncology Authors: Hiroshi Fukushima, Toshiki Kijima, Shohei Fukuda, Shingo Moriyama, Sho Uehara, Yosuke Yasuda, Hajime Tanaka, Soichiro Yoshida, Minato Yokoyama, Yoh Matsuoka, Kazutaka Saito, Nobuaki Matsubara, Noboru Numao, Yasuyuki Sakai, Takeshi Yuasa, Hi Tags: ORIGINAL RESEARCH Source Type: research

From the completion of neoadjuvant chemotherapy to surgery for colorectal cancer liver metastasis: What is the optimal timing?
ConclusionThe longer TTS after the completion of NAC may be disadvantageous for a favorable pathological response and long ‐term PFS. These results should be validated prospectively in a randomized trial. (Source: Cancer Medicine)
Source: Cancer Medicine - September 4, 2020 Category: Cancer & Oncology Authors: Qichen Chen, Rui Mao, Jianjun Zhao, Xinyu Bi, Zhiyu Li, Zhen Huang, Yefan Zhang, Jianguo Zhou, Hong Zhao, Jianqiang Cai Tags: ORIGINAL RESEARCH Source Type: research

Intra ‐CSF topotecan in treatment of breast cancer patients with leptomeningeal metastases
ConclusionsIntra ‐CSF TOPO, with focal RT as needed for symptomatic areas of enhancement produced durable clearing of CSF malignant cells in 48% of patients positive at baseline, with promising median PFS and OS. (Source: Cancer Medicine)
Source: Cancer Medicine - September 3, 2020 Category: Cancer & Oncology Authors: Kurt A. Jaeckle, Jesse G. Dixon, Stephen Keith Anderson, Alvaro Moreno ‐Aspitia, Gerardo Colon‐Otero, Kathy Hebenstreit, Tejal A. Patel, Samarth L. Reddy, Edith A. Perez Tags: ORIGINAL RESEARCH Source Type: research

Effectiveness of chemotherapy after anti ‐PD‐1 blockade failure for relapsed and refractory Hodgkin lymphoma
A substantial proportion of Hodgkin lymphoma patients ´ progresses or loses the response to anti‐PD1 treatment. In our series, a subset of heavily pre‐treated and chemo‐refractory patients increased response rates to and survival with chemotherapy given after exposure to immune‐checkpoint inhibitors. AbstractProgrammed death ‐1 (PD1) blockade is an efficient and safe therapeutic option in patients with relapsed/refractory (R/R) classical Hodgkin lymphoma (cHL). However, a substantial proportion of patients’ progresses or loses the response to anti‐PD1 treatment. We retrospectively investigated the e...
Source: Cancer Medicine - September 2, 2020 Category: Cancer & Oncology Authors: Beatrice Casadei, Lisa Argnani, Alice Morigi, Ginevra Lolli, Alessandro Broccoli, Cinzia Pellegrini, Laura Nanni, Vittorio Stefoni, Paolo E. Coppola, Matteo Carella, Michele Cavo, Pier Luigi Zinzani Tags: ORIGINAL RESEARCH Source Type: research

Gain of 1q21 is an adverse prognostic factor for multiple myeloma patients treated by autologous stem cell transplantation: A multicenter study in China
ConclusionIn conclusion, 1q21 gain is an adverse prognostic factor for MM patients received ASCT. (Source: Cancer Medicine)
Source: Cancer Medicine - September 2, 2020 Category: Cancer & Oncology Authors: Wen Gao, Yuan Jian, Juan Du, Xiaozhe Li, Huixing Zhou, Zhiyao Zhang, Guangzhong Yang, Guorong Wang, Ying Tian, Yanchen Li, Yin Wu, Weijun Fu, Juan Li, Wenming Chen Tags: ORIGINAL RESEARCH Source Type: research

Health ‐related quality of life of patients with multiple myeloma: A real‐world study in China
ConclusionsThe quality of life of patients with MM in China is affected by patient factors, difficulties experienced during the diagnosis and treatment processes, psychosocial factors, and disease ‐ or treatment‐related effects. Efforts should be exerted to improve the overall quality of life of these patients in China. (Source: Cancer Medicine)
Source: Cancer Medicine - September 2, 2020 Category: Cancer & Oncology Authors: Xiaozhe Li, Junru Liu, Meilan Chen, Jingli Gu, Beihui Huang, Dong Zheng, Juan Li Tags: ORIGINAL RESEARCH Source Type: research

Study and analysis of antitumor resistance mechanism of PD1/PD ‐L1 immune checkpoint blocker
In this study, the mechanism of anti‐PD‐1/PD‐L1 drug resistance in tumors, the potential biomarkers for predicting PD‐1 acquired resistance, and the recent development of combination therapy were reviewed one by one. It is believed that, based on the complex mechanism of drug resistan ce, it is of no clinical significance to simply search for and regulate drug resistance targets, and it may even produce drug resistance again soon. It is speculated that according to the possible tumor characteristics, three types of treatment methods should be combined to change the tumor microenv ironment ecology and eliminate vari...
Source: Cancer Medicine - September 2, 2020 Category: Cancer & Oncology Authors: Zhengyi Wang, Xiaoying Wu Tags: REVIEW Source Type: research

Staging of T2 and T3 nasopharyngeal carcinoma: Proposed modifications for improving the current AJCC staging system
Hazard ratio was lower for AJCC T3 with bone than AJCC T2 with soft tissue invasion ·The 5‐year OS and PFS were higher for re‐classified T2 than T3 stage NPC patients·Modified staging system for T2 and T3 NPC may result in better management. AbstractObjectivesWe aimed to reconstitute T2 and T3 stage classification in nasopharyngeal carcinoma (NPC) cases and verify its utility in clinical settings.Materials and MethodsWe enrolled 792 NPC patients. Cox proportional hazards model was used to compare the effect sizes (hazard ratio [HR]) of the cranial structure invasion on survival and select the structures f...
Source: Cancer Medicine - September 1, 2020 Category: Cancer & Oncology Authors: Chunyan Cui, Haojiang Li, Huali Ma, Annan Dong, Fei Xie, Shaobo Liang, Li Li, Jian Zhou, Chuanbo Xie, Yue Yan, Lizhi Liu Tags: ORIGINAL RESEARCH Source Type: research

An observational study of drug utilization and associated outcomes among adult patients diagnosed with BRAF ‐mutant advanced melanoma treated with first‐line anti‐PD‐1 monotherapies or BRAF/MEK inhibitors in a community‐based oncology setting
ConclusionThese results suggest a clinical benefit of 1L aPD ‐1 compared to BRAF/MEKi after 6 months of treatment for BRAF‐mutant advanced melanoma. Future research should explore factors associated with early progression and their relationship with clinical outcomes. (Source: Cancer Medicine)
Source: Cancer Medicine - September 1, 2020 Category: Cancer & Oncology Authors: Charles L. Cowey, Marley Boyd, Kathleen M. Aguilar, April Beeks, Clemens Krepler, Emilie Scherrer Tags: ORIGINAL RESEARCH Source Type: research

LncRNA PITPNA ‐AS1 boosts the proliferation and migration of lung squamous cell carcinoma cells by recruiting TAF15 to stabilize HMGB3 mRNA
In conclusion, our study displayed a novel mechanism underlying PITPNA‐AS1 in LUSC cells. (Source: Cancer Medicine)
Source: Cancer Medicine - September 1, 2020 Category: Cancer & Oncology Authors: Ping Ren, Lei Xing, Xiaodong Hong, Liang Chang, Hong Zhang Tags: ORIGINAL RESEARCH Source Type: research

Race modifies survival benefit of guideline ‐based treatment: Implications for reducing disparities in muscle invasive bladder cancer
ConclusionLow GBT levels demonstrated an “under‐allocation” of GBT to those who needed it most—Black individuals. Interventions to improve GBT allocation may mitigate race‐based survival differences observed in MIBC. (Source: Cancer Medicine)
Source: Cancer Medicine - September 1, 2020 Category: Cancer & Oncology Authors: Samuel L. Washington, Steven E. Gregorich, Maxwell V. Meng, Anne M. Suskind, Sima P. Porten Tags: ORIGINAL RESEARCH Source Type: research

The impact of orthotopic neobladder vs ileal conduit urinary diversion after cystectomy on the survival outcomes in patients with bladder cancer: A propensity score matched analysis
Young, married, and male patients with early pathological T stage, especially T2 stage, were more suitable to receive RC plus ON surgery, which might improve the survival probabilities. AbstractBackgroundBladder cancer (BCa) is the most common urinary malignancy. The standard surgical treatment for patients with muscle ‐invasive BCa is cystectomy plus urinary diversion. Ileal conduit (IC) or orthotopic neobladder (ON), which have different indications, are the most commonly performed urinary diversions.Methods and materialsWe sampled 5480 BCa patients from the Surveillance, Epidemiology, and End Results (SEER) database f...
Source: Cancer Medicine - September 1, 2020 Category: Cancer & Oncology Authors: Xiaohong Su, Kaihui Wu, Shuo Wang, Wei Su, Chuanyin Li, Bingkun Li, Xiangming Mao Tags: ORIGINAL RESEARCH Source Type: research

Accuracy of transvaginal sonoelastography for differential diagnosis between malignant and benign cervical lesions: A systematic review and meta ‐analysis
ConclusionTVSE has a relatively high and satisfactory value for differential diagnosis between malignant and benign cervical lesions. The diagnostic performance of strain elastography and shear wave elastography were similar and good. However, to accommodate heterogeneity and publication bias, high ‐quality studies are required to further comparative effectiveness analyses to verify the efficacy of ultrasound detection. (Source: Cancer Medicine)
Source: Cancer Medicine - September 1, 2020 Category: Cancer & Oncology Authors: Yi Zhu, Xue ‐Feng Leng, Guo‐Nan Zhang, Zi‐Yi Huang, Li Qiu, Wei Huang Tags: ORIGINAL RESEARCH Source Type: research

Genome ‐wide DNA methylation analysis by MethylRad and the transcriptome profiles reveal the potential cancer‐related lncRNAs in colon cancer
This study provided novel therapy targets and valuable insights into molecular mechanism in tu morigenesis and development of CC. AbstractColon cancer (CC) is characterized by global aberrant DNA methylation that may affect gene expression and genomic stability. A series of studies have demonstrated that DNA methylation could regulate the expressions of not only protein ‐coding genes but also ncRNAs. However, the regulatory role of lncRNA genes methylaton in CC remains largely unknown. In the present study, we systemically characterize the profile of DNA methylation, especially the aberrant methylation of lncRNAs genes u...
Source: Cancer Medicine - September 1, 2020 Category: Cancer & Oncology Authors: Guixi Zheng, Yuzhi Zhang, Hongchun Wang, E Ding, Ailin Qu, Peng Su, Yongmei Yang, Mingjin Zou, Yi Zhang Tags: ORIGINAL RESEARCH Source Type: research

Efficacy of immune ‐checkpoint inhibitors in metastatic gastric or gastroesophageal junction adenocarcinoma by patient subgroups: A systematic review and meta‐analysis
ConclusionsCompared to standard treatment, ICIs in metastatic gastric/GEJ adenocarcinoma did not improve OS. None of the evaluated subgroups has shown increased magnitude of effect to ICIs, aside of the small group with MSI ‐H tumors. (Source: Cancer Medicine)
Source: Cancer Medicine - September 1, 2020 Category: Cancer & Oncology Authors: Yulia Kundel, Michal Sternschuss, Assaf Moore, Gali Perl, Baruch Brenner, Hadar Goldvaser Tags: ORIGINAL RESEARCH Source Type: research

Microarray profiling of differentially expressed lncRNAs and mRNAs in lung adenocarcinomas and bioinformatics analysis
We performed a study in 8 lung adenocarcinomas patients and validated our observations using The Cancer Genome Atlas (TCGA) dataset. We found that 138 lncRNAs were upregulated or down regulated similarly to those in our microarray study. The lncRNA –mRNA co‐expression network was constructed based on the correlation analysis. Our results revealed that the lncRNA A2M‐AS1 exhibited the highest correlation with the co‐expressed mRNAs, indicating that it might play a key role in regulating differential gene expression in lung adenocarcinom as patients. AbstractLong noncoding RNAs (lncRNAs) dysregulation leads to ma...
Source: Cancer Medicine - September 1, 2020 Category: Cancer & Oncology Authors: Fei He, Liping Huang, Qiuping Xu, Weimin Xiong, Shuang Liu, Huimin Yang, Wanting Lu, Rendong Xiao, Zhijian Hu, Lin Cai Tags: ORIGINAL RESEARCH Source Type: research

Local staging and treatment in extremity rhabdomyosarcoma. A report from the EpSSG ‐RMS2005 study
ConclusionsEven if the lymph node staging was not always complete according to the RMS2005 protocol, node sampling changed lymph node status in a significant number of patients. Despite the higher rate of patients treated with locoregional radiotherapy, survival in RMS2005 did not improve compared to the previous European SIOP ‐MMT95 study. (Source: Cancer Medicine)
Source: Cancer Medicine - September 1, 2020 Category: Cancer & Oncology Authors: Sheila E. J. Terwisscha van Scheltinga, Marc H. W. A. Wijnen, H élène Martelli, Timothy Rogers, Henry Mandeville, Mark N. Gaze, Keiran McHugh, Nadege Corradini, Daniel Orbach, Meriel Jenney, Anna Kelsey, Julia Chisholm, Soledad Gallego, Hei Tags: ORIGINAL RESEARCH Source Type: research