Engaging rural communities in cancer prevention and control research: Development and preliminary insights from a community ‐based research registry
Community outreach and engagement builds bidirectional relationships among community members, patients, and researchers to prioritize community cancer needs. The Virginia Living Well Research and Registry (VALW) (currently n  = 595) was developed to build bidirectional exchange relationships and collect critical longitudinal cancer prevention and control data within the cancer center catchment area. AbstractObjectiveTo report on the development and preliminary findings of a community-based cancer registry, including the community-engaged approach to recruitment, participant profile, and distribution of cancer ris...
Source: Cancer Medicine - October 14, 2021 Category: Cancer & Oncology Authors: Maria D. Thomson, April R. Williams, Arnethea L. Sutton, Katherine Y. Tossas, Charlotte Garrett, Vanessa B. Sheppard Tags: RESEARCH ARTICLE Source Type: research

Preexisting immune ‐mediated inflammatory disease is associated with improved survival and increased toxicity in melanoma patients who receive immune checkpoint inhibitors
ConclusionsThe dichotomy of the impact of pre-IMID on survival and irAEs in SoC versus clinical trial patients may reflect the inherit selection bias in patients accrued in clinical trials. Future mechanistic work is required to better understand the differences in outcomes between female and male pre-IMID patients. Our data challenge the notion that clinicians should avoid ICI in pre-IMID patients, although close monitoring and prospective clinical trials evaluating ICI in this population are warranted. (Source: Cancer Medicine)
Source: Cancer Medicine - October 14, 2021 Category: Cancer & Oncology Authors: Nicholas Gulati, Arda Celen, Paul Johannet, Janice M. Mehnert, Jeffrey Weber, Michelle Krogsgaard, Iman Osman, Judy Zhong Tags: RESEARCH ARTICLE Source Type: research

Racial disparities negatively impact outcomes in early ‐onset colorectal cancer independent of socioeconomic status
We examined the effects of socioeconomic factors on outcomes for patients with early-onset CRC compared to late-onset CRC.MethodsPatients with CRC from 2004 to 2015 in the National Cancer Database were included and categorized by age (under or over 50  years). Differences in demographic and socioeconomic factors, disease characteristics, and survival outcomes between early-onset versus late-onset CRC patients were assessed by Chi-squared test and Cox models.ResultsThe study population included 1,061,204 patients, 108,058 (10.2%) of whom were under age 50. The proportion of patients diagnosed under age 50 increased ove...
Source: Cancer Medicine - October 14, 2021 Category: Cancer & Oncology Authors: Suneel D. Kamath, Nataly Torrejon, Wei Wei, Katherine Tullio, Kanika G. Nair, David Liska, Smitha S. Krishnamurthi, Alok A. Khorana Tags: RESEARCH ARTICLE Source Type: research

Nonmetastatic breast cancer patients subsequently developing second primary malignancy: A population ‐based study
ConclusionsBC survivors remained a high risk of developing SPC and considerably shortened survival time. In this study, a favorable nomogram was constructed to as a prediction model for 3-year and 5-year BCSS of BCFPM patients, largely intending to prolong the life of these patients by assisting clinicians to make individualized follow-up plans. (Source: Cancer Medicine)
Source: Cancer Medicine - October 13, 2021 Category: Cancer & Oncology Authors: Shengnan Bao, Mengping Jiang, Xi Wang, Yijia Hua, Tianyu Zeng, Yiqi Yang, Fan Yang, Xueqi Yan, Chunxiao Sun, Mengzhu Yang, Ziyi Fu, Xiang Huang, Jun Li, Hao Wu, Wei Li, Jinhai Tang, Yongmei Yin Tags: RESEARCH ARTICLE Source Type: research

Comparison of nucleoside and nucleotide analogs in the recurrence of hepatitis B virus ‐related hepatocellular carcinoma after surgical resection: A multicenter study
The aim of this study was to investigate the effect of antiviral drug on the prognosis of hepatitis B virus-related hepatocellular carcinoma (HCC) after curative hepatectomy. We found that nucleotide analog treatment, rather than nucleoside analog treatment, significantly reduced HCC recurrence and improved overall survival after curative hepatic resection. AbstractBackgroundAntiviral therapy should reduce the recurrence of hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC) after surgical resection. However, there is little research on whether various antiviral drugs have different prognostic effects in p...
Source: Cancer Medicine - October 13, 2021 Category: Cancer & Oncology Authors: Weili Qi, Junyi Shen, Junlong Dai, Youwei Wu, Yu Zhang, Shusheng Leng, Fengwei Gao, Shun Ran, Wei Peng, Xiaoyun Zhang, Tianfu Wen, Chuan Li Tags: RESEARCH ARTICLE Source Type: research

Skeletal muscle gauge as a prognostic factor in patients with colorectal cancer
Skeletal muscle gauge acts synergistically to improve its prognostic predictive accuracy as compared with skeletal muscle index or skeletal muscle radiodensity alone in patients with colorectal cancer. Additional research is warranted to define its significance in different ethnic groups. AbstractBackgroundAlthough skeletal muscle index (SMI) and radiodensity (SMD) are well-known prognostic factors, the clinical impact of the integrated measure, known as skeletal muscle gauge (SMG), has been limited in patients with colorectal cancer (CRC).Patients and MethodsA total of 727 and 268 patients with CRC at two tertiary centers...
Source: Cancer Medicine - October 13, 2021 Category: Cancer & Oncology Authors: In Kyu Park, Song Soo Yang, Eric Chung, Eun ‐Suk Cho, Hye Sun Lee, Su‐Jin Shin, Yeong Cheol Im, Eun Jung Park, Seung Hyuk Baik, Kang Young Lee, Jeonghyun Kang Tags: RESEARCH ARTICLE Source Type: research

The prognostic value of preoperative serum lactate dehydrogenase levels in patients underwent curative ‐intent hepatectomy for colorectal liver metastases: A two‐center cohort study
We retrospectively analyzed 580 patients with colorectal liver metastases (CRLM) who underwent curative-intent hepatectomy. Our study implicated preoperative LDH level as a reliable and independent laboratory biomarker to predict the clinical outcome of curative-intent surgery for CRLM. Composite of LDH and Fong score is a potential stratification tool for CRLM resection. AbstractBackgroundThe prognostic value of lactate dehydrogenase (LDH) in colorectal cancer patients has remained inconsistent between nonmetastatic and metastatic settings. So far, very few studies have included LDH in the prognostic analysis of curative-...
Source: Cancer Medicine - October 12, 2021 Category: Cancer & Oncology Authors: Long Bai, Ze ‐Yu Lin, Yun‐Xin Lu, Qin Chen, Han Zhou, Qi Meng, Chun‐Ping Lin, Wan‐Lan Huang, Yun‐Le Wan, Zhi‐Zhong Pan, De‐Shen Wang Tags: RESEARCH ARTICLE Source Type: research

Feasibility, safety, and acceptability of a remotely monitored exercise pilot CHAMP: A Clinical trial of High ‐intensity Aerobic and resistance exercise for Metastatic castrate‐resistant Prostate cancer
ConclusionsRemotely monitored exercise training is feasible, safe, and acceptable in men with mCRPC; there was no difference in these outcomes by mode of exercise. Through this research, we provide direction and rationale for future studies of exercise and clinical outcomes in patients with metastatic prostate cancer. (Source: Cancer Medicine)
Source: Cancer Medicine - October 12, 2021 Category: Cancer & Oncology Authors: Stacey A. Kenfield, Erin L. Van Blarigan, Neil Panchal, Alexander Bang, Li Zhang, Rebecca E. Graff, Yea ‐Hung Chen, Charles J. Ryan, Anthony Luke, Robert U. Newton, Imelda Tenggara, Brooke Schultz, Elizabeth Wang, Emil Lavaki, Kyle Zuniga, Tags: RESEARCH ARTICLE Source Type: research

National trends and survival outcomes of penile squamous cell carcinoma based on human papillomavirus status
ConclusionsIn the largest series evaluating pSCC based on HPV status, HPV-positive tumors were associated with lower cT stages, less LVI, but more cN  + disease. More studies on prognostic factors are needed, and time may still be immature to use HPV information for risk stratification. (Source: Cancer Medicine)
Source: Cancer Medicine - October 11, 2021 Category: Cancer & Oncology Authors: Juan Chipollini, Grant Pollock, Chiu ‐Hsieh Hsu, Ken Batai, Alejandro Recio‐Boiles, Benjamin R. Lee Tags: RESEARCH ARTICLE Source Type: research

Development and validation of pretreatment nomogram for disease ‐specific mortality in gastric cancer‐A competing risk analysis
ConclusionsThe newly developed nomogram accurately predicts DSM, which can be used for patient counseling in clinical practice. (Source: Cancer Medicine)
Source: Cancer Medicine - October 10, 2021 Category: Cancer & Oncology Authors: Etsuro Bando, Xinge Ji, Michael W. Kattan, Maria Bencivenga, Giovanni Manzoni, Masanori Terashima Tags: RESEARCH ARTICLE Source Type: research

Positive electrostatic therapy of metastatic tumors: selective induction of apoptosis in cancer cells by pure charges
ConclusionWe discovered that pure positive electrostatic charges (PECs) have an intrinsic suppressive effect on the proliferation and metabolism of invasive cancer cells (cell lines and animal models) without affecting normal tissues. The findings were statistically and observationally significant when compared to radio/chemotherapy-treated mouse models. As a result, this nonionizing radiation may be used as a practical complementary approach with no discernible side effects after passing future human model studies. (Source: Cancer Medicine)
Source: Cancer Medicine - October 9, 2021 Category: Cancer & Oncology Authors: Ashkan Zandi, Saeid Rafizadeh ‐Tafti, Fatemeh Shojaeian, Mohammad Ali Khayamian, Fereshteh Abbasvandi, Mohammad Faranoush, Robab Anbiaee, Sahar Najafikhoshnoo, Parisa Hoseinpour, Sepanta Assadi, Pouyan Katebi, Zahra Davari sh., Shahriar Shal Tags: RESEARCH ARTICLE Source Type: research

Prostate cancer in multi ‐ethnic Asian men: Real‐world experience in the Malaysia Prostate Cancer (M‐CaP) Study
Late stage at presentation remains a challenge in multi-ethnic Asian men. We observed ethnic and geographic disparities in late stage prostate cancer diagnosis. Early detection is imperative to improve treatment outcome and survival of prostate cancer patients. AbstractProstate cancer is the third most common cancer in Malaysia with the lifetime risk of 1 in 117  men. Here, we initiated a longitudinal Malaysia Prostate Cancer (M-CaP) Study to investigate the clinical and tumour characteristics, treatment patterns as well as disease outcomes of multi-ethnic Asian men at real-world setting. The M-CaP database consisted ...
Source: Cancer Medicine - October 9, 2021 Category: Cancer & Oncology Authors: Jasmine Lim, Rohan Malek, Sathiyananthan JR, Charng C. Toh, Murali Sundram, Susan Y. Y. Woo, Noor A. M. Yusoff, Guan C. Teh, Benjamin J. T. Chui, Ing S. Ngu, S. Thevarajah, Wei J. Koh, Say B. Lee, Say C. Khoo, Boon W. Teoh, Rohana Zainal, Tags: RESEARCH ARTICLE Source Type: research

Lymph node metastases > 5 and metastatic lymph node ratio > 0.30 of differentiated thyroid cancer predict response to radioactive iodine
ConclusionsWith classification tree, the study found that LNMs and LNR could predict initial response to RAI, and their optimal cutoff values were 5 and 0.30, separately. (Source: Cancer Medicine)
Source: Cancer Medicine - October 8, 2021 Category: Cancer & Oncology Authors: Canhua Yun, Juan Xiao, Jingjia Cao, Chunchun Shao, Lihua Wang, Wei Zhang, Hongying Jia Tags: RESEARCH ARTICLE Source Type: research

Highly sensitive detection of driver mutations from cytological samples and cfDNA in lung cancer
ConclusionsPeptide nucleic acid-LNA dual-PCR exhibited an excellent performance, even using cytological samples. PLDP is applicable for the investigation of cfDNA. The combination of bronchoscopy and PLDP is attractive and will expand the utility of bronchoscopy in clinical practice. (Source: Cancer Medicine)
Source: Cancer Medicine - October 7, 2021 Category: Cancer & Oncology Authors: Kazutaka Fujita, Masayuki Nakayama, Masafumi Sata, Yoshiaki Nagai, Shu Hisata, Naoko Mato, Takuji Suzuki, Masashi Bando, Nobuyuki Hizawa, Koichi Hagiwara Tags: RESEARCH ARTICLE Source Type: research

Integrated analysis of patients with KEAP1/NFE2L2/CUL3 mutations in lung adenocarcinomas
ConclusionThis research implemented the comprehensive analysis of KEAP1/NFE2L2/CUL3  somatic mutations in the LUAD patients. Compared with the wild type of LUAD patients, the Mut group shows a large difference in clinical features, RNA sequence, DNA methylation, and immune infiltrations, indicating complex mechanism oncogenesis and also reveals potential therapeutic targets. (Source: Cancer Medicine)
Source: Cancer Medicine - October 7, 2021 Category: Cancer & Oncology Authors: Xing Jin, Yuansheng Zheng, Zhencong Chen, Fei Wang, Guoshu Bi, Ming Li, Jiaqi Liang, Qihai Sui, Yunyi Bian, Zhengyang Hu, Yulei Qiao, Songtao Xu Tags: RESEARCH ARTICLE Source Type: research

Issue Information
(Source: Cancer Medicine)
Source: Cancer Medicine - October 7, 2021 Category: Cancer & Oncology Tags: ISSUE INFORMATION Source Type: research

Prognostic implication of PD ‐L1 polymorphisms in non‐small cell lung cancer treated with radiotherapy
ConclusionsThese findings suggest thatPD-L1 polymorphisms could be predictive markers for NSCLC patients receiving radiotherapy. (Source: Cancer Medicine)
Source: Cancer Medicine - October 6, 2021 Category: Cancer & Oncology Authors: Min Kyu Kang, Shin Yup Lee, Jin Eun Choi, Sook Kyung Do, Moon ‐June Cho, Jun‐Sang Kim, Jae Yong Park Tags: RESEARCH ARTICLE Source Type: research

Prognostic factors and survival prediction in HER2 ‐positive breast cancer with bone metastases: A retrospective cohort study
ConclusionOur study provided population-based clinical features and prognostic factors for HER2-positive breast cancer patients with bone metastases and we constructed a prognostic nomogram with reliable accuracy. (Source: Cancer Medicine)
Source: Cancer Medicine - October 6, 2021 Category: Cancer & Oncology Authors: Xiaoshuang Lyu, Bin Luo Tags: RESEARCH ARTICLE Source Type: research

Possibility of brigatinib ‐based therapy, or chemotherapy plus anti‐angiogenic treatment after resistance of osimertinib harboring EGFR T790M‐cis‐C797S mutations in lung adenocarcinoma patients
Epidermal growth factor receptor (EGFR) C797S mutation plays an important role on the resistance of osimertinib in advanced non-small-cell lung cancer patients. The clinical efficacy of various treatments was evaluated in 46 patients carryingEGFR T790M-cis-C797S mutation. We demonstrated the possibility of brigatinib-based therapy and chemotherapy plus anti-angiogenic might bring better clinical outcomes in those patients and the co-occurringEGFR 19del might have a better survival thanEGFR 21L858R. AbstractBackgroundThere was no standard treatment for patients who acquired resistance to osimertinib mediated by epidermal gr...
Source: Cancer Medicine - October 6, 2021 Category: Cancer & Oncology Authors: Yaning Yang, Haiyan Xu, Li Ma, Lu Yang, Guangjian Yang, Shuyang Zhang, Xin Ai, Shucai Zhang, Yan Wang Tags: RESEARCH ARTICLE Source Type: research

Novel human melanoma brain metastasis models in athymic nude fox1nu mice: Site ‐specific metastasis patterns reflecting their clinical origin
We present two new models that offer novel possibilities for investigating tumor- and host-associated factors involved in malignant melanoma brain metastasis in general and tissue-specific metastasis in particular. Two cell lines derived from a cerebral and a cerebellar human-brain metastasis gave rise to two completely different patterns of spread, where 62.9% of animals injected with the cell line derived from a cerebellar human metastasis developed cerebellar metastases compared with 2% in the group injected with the cerebral cell line. AbstractBackgroundMalignant melanomas frequently metastasize to the brain, but metas...
Source: Cancer Medicine - October 6, 2021 Category: Cancer & Oncology Authors: Henrik A. Svendsen, Torstein R. Meling, Vigdis Nygaard, Stein Waagene, Hege Russnes, Siri Juell, Siril G. Rogne, Jens Pahnke, Eirik Helseth, Øystein Fodstad, Gunhild M. Mælandsmo Tags: RESEARCH ARTICLE Source Type: research

Downregulation of CYP2E1 is associated with poor prognosis and tumor progression of gliomas
First, we identified that the downregulation of cytochrome P450 family 2 subfamily E member 1 (CYP2E1) in gliomas, CYP2E1 ’s expression level decreased with the degree of malignancy of gliomas. Then, based on functional enrichment analysis of CYP2E1 in TCGA-glioma, the association between CYP2E1 and tumor immune microenvironment, lipid metabolism, and ferroptosis were explored to explain these findings could translat e to a novel strategy to treat glioma patient with gliomas. Moreover, the total methylation level and copy number variation of CYP2E1 were moderately correlated with its mRNA expression (p 
Source: Cancer Medicine - October 6, 2021 Category: Cancer & Oncology Authors: Liguo Ye, Yang Xu, Long Wang, Chunyu Zhang, Ping Hu, Shi ’ao Tong, Zhennan Liu, Daofeng Tian Tags: RESEARCH ARTICLE Source Type: research

Identification of a glycolysis ‐related gene signature for survival prediction of ovarian cancer patients
ConclusionOur study established a nine-GRG risk model and nomogram to better predict OS in patients with OV. The risk model represents a promising and independent prognostic predictor for patients with OV. Moreover, our study on GRGs could offer guidance for the elucidation of underlying mechanisms in future studies. (Source: Cancer Medicine)
Source: Cancer Medicine - October 5, 2021 Category: Cancer & Oncology Authors: Dai Zhang, Yiche Li, Si Yang, Meng Wang, Jia Yao, Yi Zheng, Yujiao Deng, Na Li, Bajin Wei, Ying Wu, Zhen Zhai, Zhijun Dai, Huafeng Kang Tags: RESEARCH ARTICLE Source Type: research

Trust and shared decision ‐making among individuals with multiple myeloma: A qualitative study
ConclusionMany factors contribute to the development of trust between MM patients and clinicians. While some are outside of clinicians ’ control, others derive from clinician behaviors and interpersonal communication skills. These findings suggest the possibility that trust can be enhanced through communication training or shared decision-making tools that emphasize relational communication. Given the important role trust plays i n shared decision-making, clinicians working with MM patients should prioritize establishing positive, trusting relationships. (Source: Cancer Medicine)
Source: Cancer Medicine - October 5, 2021 Category: Cancer & Oncology Authors: Robin L. Whitney, Anne Elizabeth Clark White, Aaron S. Rosenberg, Richard L. Kravitz, Katherine K. Kim Tags: RESEARCH ARTICLE Source Type: research

Corrigendum
(Source: Cancer Medicine)
Source: Cancer Medicine - October 5, 2021 Category: Cancer & Oncology Tags: CORRIGENDUM Source Type: research

Dairy products and the risk of developing prostate cancer: A large ‐scale cohort study (JACC Study) in Japan
This study investigates the association between consumption of dairy product and development of prostate cancer using a large-scale cohort study in Japan. Our study makes a significant contribution to the literature because we were able to show statistically significant associations and dose –response relationships between high intake of milk and yogurt and prostate cancer, even after adjusting for potential confounders including body mass index and total energy intake. AbstractDairy products have been indicated as a risk factor for prostate cancer. However, only a few epidemiological studies have reported dairy prod...
Source: Cancer Medicine - October 4, 2021 Category: Cancer & Oncology Authors: Kazuya Mikami, Kotaro Ozasa, Tsuneharu Miki, Yoshiyuki Watanabe, Mitsuru Mori, Tatsuhiko Kubo, Koji Suzuki, Kenji Wakai, Masahiro Nakao, Akiko Tamakoshi, for the JACC Study Group Tags: RESEARCH ARTICLE Source Type: research

The immunomodulatory activity of lenvatinib prompts the survival of patients with advanced hepatocellular carcinoma
ConclusionOur results confirmed that lenvatinib is capable of improving patients ’ immune status, saving the effector cells from exhaustion status and inhibiting the number and function of immunosuppressive cells. The novel index CTL/Treg ratio qualifies as a predictor for the outcome of patients with lenvatinib therapy. (Source: Cancer Medicine)
Source: Cancer Medicine - October 4, 2021 Category: Cancer & Oncology Authors: Jie Zhu, Peiqi Fang, Chong Wang, Meixiu Gu, Baishen Pan, Wei Guo, Xinrong Yang, Beili Wang Tags: RESEARCH ARTICLE Source Type: research

Driver gene alterations profiling of Chinese non ‐small cell lung cancer and the effects of co‐occurring alterations on immunotherapy
ConclusionThis study identified a unique driver gene feature and found patients harboring co-occurring alterations ofEGFR and other driver genes may benefit from immunotherapy, which may provide more therapeutic selections for EGFR-mutated NSCLC patients and merit additional investigation. (Source: Cancer Medicine)
Source: Cancer Medicine - October 3, 2021 Category: Cancer & Oncology Authors: Shengjie Sun, Wenjuan Du, Qiong Sun, Xiao Zhao, Boyu Qin, Duozhi Shi, Chong Wan, Zhiyong Wu Tags: RESEARCH ARTICLE Source Type: research

A construction and comprehensive analysis of ceRNA networks and infiltrating immune cells in papillary renal cell carcinoma
In this study, we aimed to establish competitive endogenous RNA (ceRNA) networks related to PRCC tumorigenesis, and analyze the specific role of differentially expressed ceRNA components and infiltrating immune cells in tumorigenesis.MethodsCeRNA networks were established to identify the key ceRNAs related to PRCC tumorigenesis based on the 318 samples from The Cancer Genome Atlas database (TCGA), including 285 PRCC and 33 normal control samples. The R package, “CIBERSORT,” was used to evaluate the infiltration of 22 types of immune cells. Then we identified the significant ceRNAs and immune cells, based on whi...
Source: Cancer Medicine - October 2, 2021 Category: Cancer & Oncology Authors: Yaqi Fan, Fangfang Dai, Mengqin Yuan, Feiyan Wang, Nanhui Wu, Mingyuan Xu, Yun Bai, Yeqiang Liu Tags: RESEARCH ARTICLE Source Type: research

Incorporating genetic and clinical data into the prediction of thromboembolism risk in patients with lymphoma
This is a single-centre observational study that analyses the utility of combining genetic and clinical variables in a thromboembolism risk score in patients with lymphoma. The TiC-LYMPHO score showed a significantly higher AUC, sensitivity and NPV (0.783%, 95.35% and 97.98%, respectively) than the other scores. These results show that by incorporating genetic and clinical data into VTE risk assessment, the TiC-LYMPHO score can categorize patients with lymphoma better in terms of their risk of VTE and allow individualized thromboprophylaxis to be prescribed. AbstractBackgroundThe incorporation of genetic variables into ris...
Source: Cancer Medicine - October 1, 2021 Category: Cancer & Oncology Authors: Mariana Bastos ‐Oreiro, Javier Ortiz, Virginia Pradillo, Eduardo Salas, Carolina Marínez‐Laperche, Andrés Muñoz, Ismael Buño, José Luis Diéz‐Martin, Jose Manuel Soria, Cristina Pascual Izquierdo Tags: RESEARCH ARTICLE Source Type: research

Erratum
(Source: Cancer Medicine)
Source: Cancer Medicine - October 1, 2021 Category: Cancer & Oncology Tags: ERRATUM Source Type: research

Association of radiation dose intensity with overall survival in patients with distant metastases
Personalized radiotherapy treatment options for patients with metastatic is of significant interest and prompted investigation into higher biological equivalent doses to see if there was increased survival. Higher dose intensity was used for patients with better progresses and was associated with improved survival with metastatic diseases. AbstractBackgroundPatients with metastatic cancer referred to radiation oncology have diverse prognoses and there is significant interest in personalizing treatment. We hypothesized that patients selected for higher biologically equivalent doses have improved overall survival.MethodsThe ...
Source: Cancer Medicine - October 1, 2021 Category: Cancer & Oncology Authors: Johnny Kao, Mark K. Farrugia, Samantha Frontario, Amanda Zucker, Emily Copel, John Loscalzo, Ashish Sangal, Boramir Darakchiev, Anurag Singh, Symeon Missios Tags: RESEARCH ARTICLE Source Type: research

MicroRNA ‐501‐3p inhibits the proliferation of kidney cancer cells by targeting WTAP
ConclusionRCC progression is regulated via the miR-501-3p/WTAP/CDK2 axis and is inhibited by the overexpression of miR-501-3p. (Source: Cancer Medicine)
Source: Cancer Medicine - September 30, 2021 Category: Cancer & Oncology Authors: Liujia He, Shiming Chen, Yufan Ying, Haiyun Xie, Jiangfeng Li, Xueyou Ma, Weiyu Wang, Haixiang Shen, Xiao Wang, Xiangyi Zheng, Liping Xie Tags: RESEARCH ARTICLE Source Type: research

Patterns of National Cancer Institute ‐Sponsored Clinical Trial Enrollment in Black Adolescents and Young Adults
This study documents that compared with Black children, Black adolescent and young adult (AYA) patients were less likely to enroll in NCI-sponsored CTTs from 2000 to 2015. Black AYA male enrollment decreased with increasing age, highlighting disparities among this specific population in CTT enrollment. AbstractBackgroundBoth adolescent and young adult (AYA) and Black or African American (hereafter referred to as Black) cancer patients are historically under-enrolled in cancer treatment trials (CTT). The purpose of this study was to quantify enrollment of Black AYAs in National Cancer Institute (NCI)-sponsored CTTs overall ...
Source: Cancer Medicine - September 30, 2021 Category: Cancer & Oncology Authors: Michael Roth, Melissa Beauchemin, Justine M. Kahn, Archie Bleyer Tags: RESEARCH ARTICLE Source Type: research

Real ‐world benefit of combination palbociclib and endocrine therapy for metastatic breast cancer and correlation with neutropenia
ConclusionThe effectiveness of palbociclib and endocrine therapy in the treatment of HR-positive, HER2-negative mBC in the real-world setting is similar to the efficacy reported in the PALOMA-2 trial. Patients with lower neutrophil count may have a lower risk of early disease progression. (Source: Cancer Medicine)
Source: Cancer Medicine - September 30, 2021 Category: Cancer & Oncology Authors: James Sun, Xiaojun Zhong, Junjie Ma, Weihong Sun, Hyo S. Han, Hatem H. Soliman, Loretta S. Loftus, Ricardo L. B. Costa, Avan J. Armaghani, Aixa E. Soyano ‐Muller, Brian J. Czerniecki, M. Catherine Lee, John V. Kiluk, Nazanin Khakpour, Susa Tags: RESEARCH ARTICLE Source Type: research

SEC61G overexpression and DNA amplification correlates with prognosis and immune cell infiltration in head and neck squamous cell carcinoma
SEC61G expression in oropharyngeal cancer tissues was higher than in normal adjacent tissues. Kaplan –Meier survival analyses showed that patients with high SEC61G expression had a lower overall survival and progression-free survival than did patients with low SEC61G expression. AbstractBackgroundThe SEC61 translocon gamma subunit (SEC61G) is a component of the SEC61 complex, which import protein into the endoplasmic reticulum. However, the correlation between SEC61G and disease prognosis in head and neck squamous cell carcinoma (HNSCC) remains unclear.MethodsSEC61G expression was analyzed using publicly available da...
Source: Cancer Medicine - September 30, 2021 Category: Cancer & Oncology Authors: Tianzhu Lu, Yiping Chen, Xiaochang Gong, Qiaojuan Guo, Canyang Lin, Qingfeng Luo, Ziwei Tu, Jianji Pan, Jingao Li Tags: RESEARCH ARTICLE Source Type: research

Factors associated with distinct prognostic ‐awareness‐transition patterns over cancer patients’ last 6 months of life
ConclusionsCancer patients heterogeneously experienced PA-transition patterns over their last 6  months. Physicians’ prognostic disclosure, and patients’ symptom distress, functional dependence, and anxiety/depressive symptoms, all modifiable by high-quality end-of-life care, were associated with distinct PA-transition patterns. (Source: Cancer Medicine)
Source: Cancer Medicine - September 30, 2021 Category: Cancer & Oncology Authors: Chen Hsiu Chen, Fur ‐Hsing Wen, Wen‐Chi Chou, Jen‐Shi Chen, Wen‐Cheng Chang, Chia‐Hsun Hsieh, Siew Tzuh Tang Tags: RESEARCH ARTICLE Source Type: research

Association between Helicobacter pylori infection and mortality risk in prostate cancer patients receiving androgen deprivation therapy: A real ‐world evidence study
ConclusionsH. pylori infection was associated with a reduced risk of mortality in PCa patients receiving ADT. (Source: Cancer Medicine)
Source: Cancer Medicine - September 30, 2021 Category: Cancer & Oncology Authors: Jui ‐Ming Liu, Chun‐Te Wu, Ren‐Jun Hsu, Wen‐Lin Hsu Tags: RESEARCH ARTICLE Source Type: research

Comparison of model fit and discriminatory ability of M category as defined by the 7th and 8th editions of the tumor ‐node‐metastasis classification of colorectal cancer and the 9th edition of the Japanese classification
ConclusionsWhile the revised M category definition did not improve model fit and discriminatory ability from TNM-7 to TNM-8, further subdivision of M1c in JPC-9 improved these parameters. These results support further revisions to M1 subcategories in future editions of the TNM classification system. (Source: Cancer Medicine)
Source: Cancer Medicine - September 29, 2021 Category: Cancer & Oncology Authors: Dai Shida, Narikazu Boku, Yuya Nakamura, Takefumi Yoshida, Taro Tanabe, Kohei Yasui, Atsuo Takashima, Yukihide Kanemitsu Tags: RESEARCH ARTICLE Source Type: research

Impact of angiogenesis inhibitor eligibility on the prognosis of patients with non ‐small cell lung cancer harboring EGFR mutation
In this study, the data for 450 patients withEGFR-mutant NSCLC, who were treated with EGFR-TKI monotherapy, were retrospectively analyzed for AI eligibility. The patients were categorized into AI-eligible (AI fit) and ineligible groups (AI unfit).ResultsThe median PFS of the AI fit group was 12.9  months, compared to 9.6 months in the unfit group (p = 0.007), and OS was also significantly longer in the AI fit group (median OS = 33.0 months) compared to that in the unfit group (18.5 months,p 
Source: Cancer Medicine - September 29, 2021 Category: Cancer & Oncology Authors: Hiroaki Kodama, Hirotsugu Kenmotsu, Takanori Kawabata, Akifumi Notsu, Michitoshi Yabe, Naoya Nishioka, Eriko Miyawaki, Taichi Miyawaki, Nobuaki Mamesaya, Haruki Kobayashi, Shota Omori, Kazushige Wakuda, Akira Ono, Tateaki Naito, Haruyasu Mur Tags: RESEARCH ARTICLE Source Type: research

Diagnostic models for impending death in terminally ill cancer patients: A multicenter cohort study
ConclusionWe successfully developed diagnostic models for death ≤3 days. These may further help clinicians predict impending death and help patients/families prepare for their final days. (Source: Cancer Medicine)
Source: Cancer Medicine - September 29, 2021 Category: Cancer & Oncology Authors: Masanori Mori, Takuhiro Yamaguchi, Isseki Maeda, Yutaka Hatano, Takashi Yamaguchi, Kengo Imai, Ayako Kikuchi, Yosuke Matsuda, Kozue Suzuki, Satoru Tsuneto, David Hui, Tatsuya Morita, EASED collaborators Tags: RESEARCH ARTICLE Source Type: research

Risk factors associated with suicide in adolescents and young adults (AYA) with cancer
ConclusionsDeath due to suicide/non-accidental injury is high compared to normative data, requiring increased awareness among health-care providers, suicide risk monitoring in AYA, and appropriately tailored psychosocial interventions. (Source: Cancer Medicine)
Source: Cancer Medicine - September 29, 2021 Category: Cancer & Oncology Authors: Sarah Heynemann, Kate Thompson, Donovan Moncur, Sandun Silva, Madawa Jayawardana, Jeremy Lewin Tags: RESEARCH ARTICLE Source Type: research

Life dissatisfaction in Canadians aged 40 and above with cancer and mental health disorders: A cross ‐sectional study using the Canadian Community Health Survey
ConclusionThis study showed higher life dissatisfaction in cancer and mental health disorder patients. A synergistic effect was detected between cancer and mental health disorder on life dissatisfaction. These results suggest cancer patients with mental health disorders require additional support and psychological resources to improve their quality of life. (Source: Cancer Medicine)
Source: Cancer Medicine - September 28, 2021 Category: Cancer & Oncology Authors: Danielle Carole Roy, Ronda Lun, Tzu ‐Fei Wang, Yue Chen, Philip Wells Tags: RESEARCH ARTICLE Source Type: research

Evidence to guide the optimal timing for pre ‐chemotherapy blood tests for early breast, colorectal cancer and diffuse large B‐cell lymphoma
ConclusionsWe have demonstrated that extending the timeframe for blood tests can be safe, however, this practice may cause unnecessary delays for patients if only an early test is relied on for eligibility. (Source: Cancer Medicine)
Source: Cancer Medicine - September 28, 2021 Category: Cancer & Oncology Authors: Pinkie Chambers, Li Wei, Martin D. Forster, Emma Kipps, Ian C. K. Wong, Yogini Jani Tags: RESEARCH ARTICLE Source Type: research

MLL3 is a de novo cause of endocrine therapy resistance
ConclusionsOur data show that a decrease in functional MLL3  leads to endocrine therapy resistance. This highlights the importance of genotyping patient tumor samples forMLL3 mutation upon initial resection, prior to deciding upon treatment plans. (Source: Cancer Medicine)
Source: Cancer Medicine - September 28, 2021 Category: Cancer & Oncology Authors: Kimberly M. Stauffer, David L. Elion, Rebecca S. Cook, Thomas Stricker Tags: RESEARCH ARTICLE Source Type: research

The beneficial effect of Escalated ‐R‐CHOP‐21 for the treatment of diffuse large B‐cell lymphoma in elderly male patients: A propensity‐matched cohort study
ConclusionEscalated-R-CHOP-21 could be a safe and effective option for treating elderly male patients with DLBCL. This study provides new insight into optimizing the standard treatment regimen, which may have important therapeutic implications in elderly male patients with DLBCL. (Source: Cancer Medicine)
Source: Cancer Medicine - September 28, 2021 Category: Cancer & Oncology Authors: Hai ‐Xia He, Yan Gao, Bing Bai, Xiao‐Xiao Wang, Ji‐Bin Li, Cheng Huang, Jia‐Ying Mao, Li‐Qin Ping, Qi‐Xiang Rong, Yan‐Xia He, He Huang, Qing‐Qing Cai, Zhi‐Ming Li, Wen‐Qi Jiang, Hui‐Qiang Huang Tags: RESEARCH ARTICLE Source Type: research

Integrated analysis identifies a novel lncRNA prognostic signature associated with aerobic glycolysis and hub pathways in breast cancer
In conclusion, we identified five glycolysis-related lncRNAs to construct a lncRNA signature on the basis of the glycolysis score, which could predict survival probability and glycolysis status. Moreover, hallmark gene sets associated with cell growth were significantly activated in the high-risk breast cancer patient subgroup. Overall, the lncRNA signature could function as a robust prognostic indicator and help develop novel therapeutic strategies for breast cancer patients. AbstractLong noncoding RNAs (lncRNAs) play a crucial role in cancer aerobic glycolysis. However, glycolysis-related lncRNAs are still underexplored ...
Source: Cancer Medicine - September 28, 2021 Category: Cancer & Oncology Authors: Zheng Li, Juan Zheng, Yang Feng, Yaming Li, Yiran Liang, Ying Liu, Xiaolong Wang, Qifeng Yang Tags: RESEARCH ARTICLE Source Type: research

Effectiveness of various human papillomavirus vaccination strategies: A community randomized trial in Finland
ConclusionsThis study illustrates the difficulty in conducting community randomized trials. It is not plausible that vaccinating boys would reduce overall effectiveness, and the apparent lack of herd effect was unexpected given findings from other studies. This analysis was likely confounded by several factors but confirms the vaccine's high total effectiveness as in clinical trials. (Source: Cancer Medicine)
Source: Cancer Medicine - September 28, 2021 Category: Cancer & Oncology Authors: Matti Lehtinen, Dan Apter, Tiina Eriksson, Katja Harjula, Mari Hokkanen, Kari Natunen, Pekka Nieminen, Jorma Paavonen, Johanna Palmroth, Tiina Pet äjä, Eero Pukkala, Simopekka Vänskä, Brigitte Cheuvart, Maaria Soila, Dan Bi, Frank Struy Tags: RESEARCH ARTICLE Source Type: research

Construction of circRNA ‐based ceRNA network and its prognosis‐associated subnet of clear cell renal cell carcinoma
This study was designed to identify circRNAs related to patients with clear cell renal cell carcinoma (ccRCC) and the first to select three independent Gene Expression Omnibus microarrays covering circRNAs, miRNAs, and mRNAs for multiple analyses. The data of clinical cases applied in our study were obtained from The Cancer Genome Atlas. We successfully conducted a circRNA/miRNA/mRNA ceRNA network related to ccRCC patients via R software and Cytoscape including 8 circRNAs, 6 miRNAs, and 49 mRNAs. The prognosis-associated subnet covered 8 circRNAs, 6 miRNAs, and 22 mRNAs. Quantitative real-time PCR was applied to measure ou...
Source: Cancer Medicine - September 27, 2021 Category: Cancer & Oncology Authors: Yuwei Zhang, Yuchen Zhang, Yangkun Feng, Nan Zhang, Saisai Chen, Chaoqun Gu, Lei Hu, Jiayi Sheng, Bin Xu, Ninghan Feng Tags: RESEARCH ARTICLE Source Type: research

Retraction
(Source: Cancer Medicine)
Source: Cancer Medicine - September 27, 2021 Category: Cancer & Oncology Tags: RETRACTION Source Type: research

Recombinant human thrombopoietin improved platelet engraftment after autologous hematopoietic stem cell transplantation in patients with newly diagnosed multiple myeloma
This study aimed to evaluate the efficacy and safety of recombinant human thrombopoietin (rhTPO) for hematopoietic reconstitution after autologous stem cell transplant (ASCT) in patients with newly diagnosed multiple myeloma (NDMM). Multivariate analysis showed that rhTPO administration was an independent factor for accelerating platelet engraftment. Survival analysis showed no decrease on TTP or OS by rhTPO application. AbstractBackgroundTo evaluate the efficacy and safety of recombinant human thrombopoietin (rhTPO) for hematopoietic reconstitution after autologous stem cell transplant (ASCT) in patients with newly diagno...
Source: Cancer Medicine - September 27, 2021 Category: Cancer & Oncology Authors: Jingli Gu, Junru Liu, Xiaozhe Li, Waiyi Zou, Beihui Huang, Meilan Chen, Juan Li Tags: RESEARCH ARTICLE Source Type: research