Outcomes of axitinib versus sunitinib as first ‐line therapy to patients with metastatic renal cell carcinoma in the immune‐oncology era
This study was aimed at comparing the efficacy of two TKIs —axitinib and sunitinib—in mRCC patients. From January 2008 to October 2018, we registered 703 mRCC patients from 8 Japanese institutes. Of these, 408 patients received axitinib or sunitinib as the first-line treatment. Thereafter, efficacy and survival rate were compared between the axitinib and sunitinib groups. To reduce the effects of selection bias and potential confounders, propensity score matching analysis was performed. Axitinib and sunitinib were administered in 274 and 134 patients, respectively. More than 25% of the patients receiv...
Source: Cancer Medicine - July 27, 2021 Category: Cancer & Oncology Authors: Kazuyuki Numakura, Yumin Muto, Sei Naito, Shingo Hatakeyama, Renpei Kato, Tomoyuki Koguchi, Takahiro Kojima, Yoshihide Kawasaki, Syuya Kandori, Sadafumi Kawamura, Yoichi Arai, Akihiro Ito, Hiroyuki Nishiyama, Yoshiyuki Kojima, Wataru Obara, Tags: RESEARCH ARTICLE Source Type: research

Thirty ‐day hospital readmission rate, reasons, and risk factors after acute inpatient cancer rehabilitation
Conclusion and RelevanceAmong adult patients with cancer discharged to home setting after acute inpatient rehabilitation, the 30-day readmission rate of 21% was higher than that reported for other rehabilitation populations but within the range reported for patients with cancer who did not undergo acute inpatient rehabilitation. (Source: Cancer Medicine)
Source: Cancer Medicine - July 27, 2021 Category: Cancer & Oncology Authors: Jegy M. Tennison, Nahid J. Rianon, Joanna G. Manzano, Mark F. Munsell, Marina C. George, Eduardo Bruera Tags: RESEARCH ARTICLE Source Type: research

An aberrant DNA methylation signature for predicting the prognosis of head and neck squamous cell carcinoma
AbstractHead and neck squamous cell carcinoma (HNSCC) is a common malignancy worldwide with a poor prognosis. DNA methylation is an epigenetic modification that plays a critical role in the etiology and pathogenesis of HNSCC. The current study aimed to develop a predictive methylation signature based on bioinformatics analysis to improve the prognosis and optimize therapeutic outcome in HNSCC. Clinical information and methylation sequencing data of patients with HNSCC were downloaded from The Cancer Genome Atlas database. The R package was used to identify differentially methylated genes (DMGs) between HNSCC and adjacent n...
Source: Cancer Medicine - July 27, 2021 Category: Cancer & Oncology Authors: Dayang Chen, Mengmeng Wang, Ying Guo, Wei Wu, Xiang Ji, Xiaowen Dou, Huamei Tang, Zengyan Zong, Xiuming Zhang, Dan Xiong Tags: RESEARCH ARTICLE Source Type: research

DYRK1A activates NFATC1 to increase glioblastoma migration
We found that DYRK1A protein was positively correlated with that of NFATc1 through affecting NFATc1  degradation and transactivation in GBM cells. DYRK1A inhibition or polypeptide derived from DYRK1A-targeted motif of NFATc1, clearly destabilized NFATc1 protein and impaired glioblastoma migration. We propose that the recovery of NFATc1 stability is a key oncogenic event in a large proportion of gliomas and polypeptide pharmacological inhibition of DYRK1A could represent a promising therapeutic intervention for NFATc1-dependent GBM. AbstractGlioblastoma (GBM) is the most aggressive glioma, and is prone to develop ...
Source: Cancer Medicine - July 26, 2021 Category: Cancer & Oncology Authors: Heng Liu, Qian Sun, Shuai Chen, Long Chen, Wenming Jia, Juan Zhao, Xiulian Sun Tags: RESEARCH ARTICLE Source Type: research

Trajectories and risk factors for anxiety and depression in children and adolescents with cancer: A 1 ‐year follow‐up
This study aimed to longitudinally assess the trajectories and risk factors for anxiety and depressive symptoms in children and adolescents with cancer. We used a unique model of assessment combining the K-SADS structured psychiatric interview along with the short PROMIS self and parent report at four time points during one year. Our results highlight the importance of screening for anxiety and disorders in children with cancer, especially among those with brain tumors and at the acute phase of treatment. AbstractBACKGROUNDThere is limited data on the longitudinal trajectories of psychiatric disorders in children with canc...
Source: Cancer Medicine - July 26, 2021 Category: Cancer & Oncology Authors: Maya Yardeni, Gadi Abebe Campino, Ilanit Hasson ‐Ohayon, Dana Basel, Nimrod Hertz‐Palmor, Shira Bursztyn, Hana Weisman, Itai M. Pessach, Amos Toren, Doron Gothelf Tags: RESEARCH ARTICLE Source Type: research

Comprehensive analysis of a new prognosis signature based on histone deacetylases in clear cell renal cell carcinoma
Risk model consisting of HDAC8, HDAC10, and HDAC11  have a favorable role of risk prediction in ccRCC. Immune-associated functions and pathways were enriched in HDACs, and most of HDACs are related to tumor stemness, stromal cell, and immune cells. Several clinical characteristics are associated with HDACs expression and the activity of some common ly used drugs (such as oxaliplatin, vorinostat, temsirolimus) are also influenced by HDACs. AbstractHistone deacetylases (HDAC) family is vital for tumorigenesis and tumor progression. However, the exact role of the HDAC family in clear cell renal cell carcinoma (ccRCC) rem...
Source: Cancer Medicine - July 26, 2021 Category: Cancer & Oncology Authors: Fajuan Cheng, Bin Zheng, Jianwei Wang, Guiting Zhao, Zhongshun Yao, Zhihong Niu, Wei He Tags: RESEARCH ARTICLE Source Type: research

The prognostic utility of pre ‐treatment neutrophil‐to‐lymphocyte‐ratio (NLR) in colorectal cancer: A systematic review and meta‐analysis
In this report, the authors explore a simple full-blood-count-derived metric, the neutrophil-to-lymphocyte ratio (NLR), as a prognostic factor in colorectal cancer. Based on 71 publications, accounting for 32,788 patients, high NLR emerges as a readily available predictor of poor clinical outcome both for overall survival and surrogate endpoints, such as disease or progression-free survival. AbstractBackgroundInflammation is a hallmark of cancer, and systemic markers of inflammation are increasingly recognised as negative prognostic factors for clinical outcome. Neutrophil-to-lymphocyte ratio (NLR) is readily available fro...
Source: Cancer Medicine - July 26, 2021 Category: Cancer & Oncology Authors: Mate Naszai, Alina Kurjan, Timothy S. Maughan Tags: RESEARCH ARTICLE Source Type: research

LungBEAM: A prospective multicenter study to monitor stage IV NSCLC patients with EGFR mutations using BEAMing technology
The manuscript is a multicenter, prospective study conducted in the real-world setting. The study reveals that the detection and quantification (MAF slope) of EGFR mutations in ctDNA using the highly sensitive BEAMing method may assist in optimizing treatment decisions for advanced NSCLC patients. AbstractObjectivesThe aim of LungBEAM was to determine the value of a novel epidermal growth factor receptor (EGFR) mutation test in blood based on BEAMing technology to predict disease progression in advanced non-small cell lung cancer (NSCLC) patients treated with first- or second-generation EGFR-tyrosine kinase inhibitors (EGF...
Source: Cancer Medicine - July 23, 2021 Category: Cancer & Oncology Authors: Pilar Garrido, Luis Paz ‐Ares, Margarita Majem, Teresa Morán, José Manuel Trigo, Joaquim Bosch‐Barrera, Rosario Garcίa‐Campelo, José Luis González‐Larriba, José Miguel Sánchez‐Torres, Dolores Isla, Núria Viñolas, Carlos Camps Tags: ORIGINAL RESEARCH Source Type: research

Early detection of metastatic uveal melanoma by the analysis of tumor ‐specific mutations in cell‐free plasma DNA
ConclusionDetection of ctDNA in plasma can provide a diagnostic lead time over the clinical diagnosis of metastases or tumor recurrence. Longer lead times are to be expected if intervals between sampling are shortened. (Source: Cancer Medicine)
Source: Cancer Medicine - July 22, 2021 Category: Cancer & Oncology Authors: Claudia H. D. Le Guin, Norbert Bornfeld, Nikolaos E. Bechrakis, Leyla Jabbarli, Heike Richly, Dietmar R. Lohmann, Michael Zeschnigk Tags: RESEARCH ARTICLE Source Type: research

A microRNA ‐clinical prognosis model to predict the overall survival for kidney renal clear cell carcinoma
In conclusion, the miRNA-clinical model provides an effective and accurate way to predict the prognosis of KIRC. (Source: Cancer Medicine)
Source: Cancer Medicine - July 21, 2021 Category: Cancer & Oncology Authors: Yating Zhan, Rongrong Zhang, Chunxue Li, Xuantong Xu, Kai Zhu, Zhan Yang, Jianjian Zheng, Yong Guo Tags: RESEARCH ARTICLE Source Type: research

Clinical presentation and survival outcomes of well ‐differentiated thyroid cancer in Filipinos
ConclusionFilipino patients with thyroid cancer are more likely to present with locoregionally advanced disease compared with non-Filipino Asians and non-Asians. Furthermore, Filipino patients have worse survival outcomes compared with non-Filipino Asians and non-Asians. However, this appears to be driven by the higher rates of locoregionally advanced disease in Filipino patients. (Source: Cancer Medicine)
Source: Cancer Medicine - July 21, 2021 Category: Cancer & Oncology Authors: Uchechukwu C. Megwalu, Yifei Ma, Nosayaba Osazuwa ‐Peters, Lisa A. Orloff Tags: RESEARCH ARTICLE Source Type: research

Perception versus reality: A National Cohort Analysis of the surgery ‐first approach for resectable pancreatic cancer
ConclusionDespite the perceived benefit of UFS, only 1-in-5 UFS patients actually realize maximal survival when known factors highly associated with outcomes are assessed. Patients are proportionally more likely to do worst, rather than best after UFS treatment. Similarly staged patients undergoing ITT-neoadjuvant therapy achieve survival superior to the majority of UFS patients. Patients and providers should be aware of the false perception of ‘optimal’ survival benefit with UFS in anatomically resectable PDAC. (Source: Cancer Medicine)
Source: Cancer Medicine - July 21, 2021 Category: Cancer & Oncology Authors: John R. Bergquist, Cornelius A. Thiels, Christopher R. Shubert, Tommy Ivanics, Elizabeth B. Habermann, Santhi S. Vege, Travis E. Grotz, Sean P. Cleary, Rory L. Smoot, Michael L. Kendrick, David M. Nagorney, Mark J. Truty Tags: RESEARCH ARTICLE Source Type: research

Worth it or not? Primary tumor resection for stage IV pancreatic cancer patients: A SEER ‐based analysis of 15,836 cases
ConclusionPTR improves the OS and CSS of stage IV PC patients on the basis of chemotherapy or chemoradiotherapy, provided that the metastases involve ≤1 organ. Chemotherapy, however, should be carefully considered in patients with metastases involving the brain. (Source: Cancer Medicine)
Source: Cancer Medicine - July 21, 2021 Category: Cancer & Oncology Authors: Ningzhen Fu, Yu Jiang, Yuanchi Weng, Hao Chen, Xiaxing Deng, Baiyong Shen Tags: RESEARCH ARTICLE Source Type: research

Mutational profiling in acute lymphoblastic leukemia by RNA sequencing and chromosomal genomic array testing
ConclusionsWe conclude that FusionPlex is a robust and reliable anchored multiplex RNA sequencing platform for use in the detection of fusions in both fresh cryopreserved and cytogenetic fixed pellets. Gene expression data could only be obtained from fresh samples and although limited variant data are available, critical hotspot variants can be determined in conjunction with the fusions. (Source: Cancer Medicine)
Source: Cancer Medicine - July 21, 2021 Category: Cancer & Oncology Authors: Cecilia Yeung, Xiaoyu Qu, Olga Sala ‐Torra, David Woolston, Jerry Radich, Min Fang Tags: ORIGINAL RESEARCH Source Type: research

Issue Information
(Source: Cancer Medicine)
Source: Cancer Medicine - July 20, 2021 Category: Cancer & Oncology Tags: ISSUE INFORMATION Source Type: research

Incidence trends of squamous cell carcinoma of the head and neck (SCCHN) in the aging population ––A SEER‐based analysis from 2000 to 2016
This study reports results that are consistent with other studies demonstrating that the prevalence HPV associated of head and neck cancer overall is increasing in the elderly population age ≥65 years. This increase is occurring when stratified by race, sex, and birth cohort however, the White male population is experiencing the most significant annual percent increase in the incidence of HPV-associated head and neck cancers. HPV-associated head and neck cancers are no longer a disea se associated with younger patients and the increasing prevalence of this disease in the elderly population is important when conside...
Source: Cancer Medicine - July 20, 2021 Category: Cancer & Oncology Authors: Melissa A. Taylor, Jeffery Switchenko, William Stokes, Mihir R. Patel, Mark McDonald, Conor Steuer, Ashley Aiken, Jonathan J. Beitler, Dong M. Shin, Nabil F. Saba Tags: ORIGINAL RESEARCH Source Type: research

Clinical outcomes of stereotactic magnetic resonance image ‐guided adaptive radiotherapy for primary and metastatic tumors in the abdomen and pelvis
We report the clinical outcomes of stereotactic MRI-guided adaptive radiotherapy (SMART) for primary and metastatic tumors in the abdomen and pelvis.MethodsFrom November 2014 to August 2017, the first 106 consecutive patients with 121 tumors in the abdomen and pelvis were treated with SMART at a single institution. Of the cohort, 41.5%, 15.1%, and 43.4% had primary, locally recurrent, and oligometastatic tumors, respectively. SMART was delivered using a tri-cobalt-60 gantry with on-board 0.35 Tesla MRI with respiratory breath-hold and daily adaptive re-planning when anatomically necessary. A median of 40Gy in five fraction...
Source: Cancer Medicine - July 20, 2021 Category: Cancer & Oncology Authors: Stephanie M. Yoon, Elaine Luterstein, Fang ‐I Chu, Minsong Cao, James Lamb, Nzhde Agazaryan, Daniel Low, Ann Raldow, Michael L. Steinberg, Percy Lee Tags: RESEARCH ARTICLE Source Type: research

Preoperative magnetic resonance imaging criteria for predicting lymph node metastasis in patients with stage IB1 ‐IIA2 cervical cancer
This study aimed to identify patients with stage IB1-IIA2 cervical cancer at low risk for lymph node metastasis (LNM) using preoperative magnetic resonance imaging (MRI) parameters.MethodsClinical and MRI data of patients with stage IB1-IIA2 cervical cancer who underwent radical surgery between 2010 and 2015 were retrospectively reviewed. Clinical stage IB1-IIA2 cervical cancer was diagnosed according to the 2009 International Federation of Gynecology and Obstetrics staging system. The low-risk criteria for LNM were identified using logistic regression analysis. The performance of the logistic regression analysis was estim...
Source: Cancer Medicine - July 19, 2021 Category: Cancer & Oncology Authors: Fangjie He, Shuiling Zu, Xia Chen, Jianping Liu, Ying Yi, Haijun Yang, Fuqiang Wang, Songhua Yuan Tags: RESEARCH ARTICLE Source Type: research

Anterior wall adenocarcinoma of bladder with similar clinicopathological and prognostic characteristics as common bladder carcinomas should not be treated as or classified into urachal adenocarcinomas
ConclusionThis study illustrates that PTL of UAC and BAC was an independent predictor for survival. A-BAC had comparable characters and prognosis with O-BAC and should not be classified into and treated as UrC. For non-metastatic disease, non-metastatic D-BAC may need more intensive modality. (Source: Cancer Medicine)
Source: Cancer Medicine - July 19, 2021 Category: Cancer & Oncology Authors: Yu ‐Wen Zhou, Yi‐Xiu Long, Kun Song, Li‐Bo Liang, Ke Cheng, Ye Chen, Ji‐Yan Liu Tags: ORIGINAL RESEARCH Source Type: research

HOXD13 promotes the malignant progression of colon cancer by upregulating PTPRN2
ConclusionWe revealed the function and mechanism of HOXD13 in colon cancer and suggest that HOXD13  may be a candidate marker for the diagnosis and treatment of colon cancer. (Source: Cancer Medicine)
Source: Cancer Medicine - July 18, 2021 Category: Cancer & Oncology Authors: Jiangyan Yin, Yi Guo Tags: ORIGINAL RESEARCH Source Type: research

An analysis of the use of targeted therapies in patients with advanced Merkel cell carcinoma and an evaluation of genomic correlates of response
ConclusionIn our series, targeted agents elicited a disease control rate of 19% in patients with advanced MCC, with a best overall response of SD. Pazopanib alone or in combination exhibited a rate of disease control of 36% (4 of 11 with SD ≥6 months). (Source: Cancer Medicine)
Source: Cancer Medicine - July 16, 2021 Category: Cancer & Oncology Authors: Todd C. Knepper, Robyn A. Panchaud, Elnara Muradova, Leah Cohen, James A. DeCaprio, Nikhil I. Khushalani, Kenneth Y. Tsai, Andrew S. Brohl Tags: ORIGINAL RESEARCH Source Type: research

SphK1 ‐driven autophagy potentiates focal adhesion paxillin‐mediated metastasis in colorectal cancer
SphK1-driven autophagy may promote the invasion and metastasis of CRC via promoting of the expression of focal adhesion paxillin and its phosphorylation. AbstractInvasion and metastasis are the main causes of colorectal cancer (CRC)-related death. Accumulating evidence suggested that sphingosine kinase 1 (SphK1) promoted the metastasis of CRC and autophagy played an important role in SphK1 promoting the metastasis of malignancy. However, the mechanism by which SphK1-driven autophagy promotes invasion and metastasis in CRC remains to be clarified. In the present study, immunohistochemical detection showed the expression of ...
Source: Cancer Medicine - July 16, 2021 Category: Cancer & Oncology Authors: Jiang ‐Ni Wu, Lan Lin, Shi‐Bo Luo, Xin‐Ze Qiu, Li‐Ye Zhu, Da Chen, Er‐Dan Wei, Zhen‐Hua Fu, Meng‐Bin Qin, Zhi‐Hai Liang, Jie‐An Huang, Shi‐Quan Liu Tags: ORIGINAL RESEARCH Source Type: research

Significantly high expression of NUP37 leads to poor prognosis of glioma patients by promoting the proliferation of glioma cells
ConclusionsThis study demonstrates for the first time a malignant role of NUP37 in glioma and provides a vision to unravel the complex pathological mechanisms of glioma and a potentially valuable biomarker for implementing individualized diagnosis and treatment of glioma. (Source: Cancer Medicine)
Source: Cancer Medicine - July 15, 2021 Category: Cancer & Oncology Authors: Zhendong Liu, Hongbo Wang, Yulong Jia, Jialin Wang, Yanbiao Wang, Lu Bian, Binfeng Liu, Xiaoyu Lian, Bo Zhang, Zhishuai Ren, Wang Zhang, Weiwei Dai, Yanzheng Gao Tags: ORIGINAL RESEARCH Source Type: research

Identification of a competing endogenous RNA axis “SVIL‐AS1/miR‐103a/ICE1” associated with chemoresistance in lung adenocarcinoma by comprehensive bioinformatics analysis
ConclusionsSVIL-AS1 inhibited chemoresistance by acting as a sponge for miR-103a and upregulating ICE1 expression, which may be a potential therapeutic target for chemotherapy in LUAD. (Source: Cancer Medicine)
Source: Cancer Medicine - July 15, 2021 Category: Cancer & Oncology Authors: Lili Guo, Lina Ding, Junfang Tang Tags: ORIGINAL RESEARCH Source Type: research

Has tumor doubling time in breast cancer changed over the past 80 years? A systematic review
The stability of tumor doubling time over the past 80  years, despite increasing and changing risk factors, supports the validity of our screening guidelines. Recent studies have not only identified “fast growing tumor” but also “inactive breast cancer” feeding the ongoing debate of overdiagnosis due to screening programs. AbstractOver the past century, epidemiologic changes and implementation of screening may have had an impact on tumor doubling time in breast cancer. Our study was designed to evaluate changes in tumor doubling time in breast cancer over the past 80  years. A systematic r...
Source: Cancer Medicine - July 15, 2021 Category: Cancer & Oncology Authors: Meryl Dahan, Delphine Hequet, Claire Bonneau, Xavier Paoletti, Roman Rouzier Tags: REVIEW Source Type: research

Predictive role of diffusion ‐weighted whole‐body MRI (DW‐MRI) imaging response according to MY‐RADS criteria after autologous stem cell transplantation in patients with multiple myeloma and combined evaluation with MRD assessment by flow cytometry
ConclusionThe present study supports the applicability of MY-RADS recommendations after ASCT; RAC criteria were able to independently stratify patients and to better predict their prognosis and the combined use of DW-MRI with MFC allowed a more precise evaluation of MRD. (Source: Cancer Medicine)
Source: Cancer Medicine - July 15, 2021 Category: Cancer & Oncology Authors: Angelo Belotti, Rossella Ribolla, Valeria Cancelli, Alberta Villanacci, Valentina Angelini, Marco Chiarini, Viviana Giustini, Giulia V. Facchetti, Aldo M. Roccaro, Samantha Ferrari, Annalisa Peli, Chiara Bottelli, Chiara Cattaneo, Claudia Cri Tags: ORIGINAL RESEARCH Source Type: research

Parallel comparison of R.E.N.A.L., PADUA, and C ‐index scoring systems in predicting outcomes after partial nephrectomy: A systematic review and meta‐analysis
AbstractObjectiveTo parallelly compare the applicability of the radius, exophytic/endophytic, nearness, anterior/posterior, location nephrometry score (R.E.N.A.L.), the Preoperative Aspects and Dimensions Used for an Anatomical (PADUA), and the centrality index (C-index) scoring systems in predicting clinical outcomes after partial nephrectomy (PN).MethodsWe searched EMBASE, PubMed, Ovid, and Web of Science to perform a meta-analysis examining the correlation coefficients between three nephrometry scores (NSs) and warm ischemia time (WIT), estimated blood loss (EBL), operation time (OT), length of stay (LOS), and absolute ...
Source: Cancer Medicine - July 14, 2021 Category: Cancer & Oncology Authors: Can Hu, Jiale Sun, Zhiyu Zhang, Haoyang Zhang, Qi Zhou, Jiangnan Xu, Zhixin Ling, Jun Ouyang Tags: ORIGINAL RESEARCH Source Type: research

A comprehensive analysis of immune infiltration in the tumor microenvironment of osteosarcoma
ConclusionsTo the best of our knowledge, this is the first study to characterize the infiltration of immune cells in osteosarcoma tissues from patients receiving immune infiltration therapy. (Source: Cancer Medicine)
Source: Cancer Medicine - July 14, 2021 Category: Cancer & Oncology Authors: Hao Yang, Liang Zhao, Yang Zhang, Fang ‐Fang Li Tags: ORIGINAL RESEARCH Source Type: research

Sequential treatment of afatinib and osimertinib or other regimens in patients with advanced non ‐small‐cell lung cancer harboring EGFR mutations: Results from a real‐world study in South Korea
ConclusionSequential afatinib and osimertinib treatment resulted in better survival rates than treatment with afatinib followed by other chemotherapies. (Source: Cancer Medicine)
Source: Cancer Medicine - July 14, 2021 Category: Cancer & Oncology Authors: Taeyun Kim, Tae Won Jang, Chang Min Choi, Mi ‐Hyun Kim, Sung Yong Lee, Cheol‐Kyu Park, Yoon Soo Chang, Kye Young Lee, Seung Joon Kim, Sei Hoon Yang, Jeong Seon Ryu, Jeong Eun Lee, Shin Yup Lee, Chan Kwon Park, Sang Hoon Lee, Seung Hun J Tags: RESEARCH ARTICLE Source Type: research

Diverse patient trajectories during cytotoxic chemotherapy: Capturing longitudinal patient ‐reported outcomes
ConclusionsPatient-reported outcomes are increasingly used to help monitor cancer treatment and are now a part of care reimbursement. This study leveraged routinely collected PROMIS surveys linked to EHRs to identify novel patient trajectories of physical and mental well-being in oncology patients undergoing chemotherapy and potential predictors. Supportive care interventions in high-risk populations identified by our study may optimize resource deployment.Novelty and impactThis study leveraged routinely collected patient-reported outcome (PROMIS) surveys linked to electronic health records to characterize oncology patient...
Source: Cancer Medicine - July 13, 2021 Category: Cancer & Oncology Authors: Amee D. Azad, Melih Yilmaz, Selen Bozkurt, James D. Brooks, Douglas W. Blayney, Tina Hernandez ‐Boussard Tags: ORIGINAL RESEARCH Source Type: research

Comorbidity, lifestyle factors, and sexual satisfaction among Chinese cancer survivors
ConclusionComorbidity and lifestyle factors are associated with sexual satisfaction of cancer survivors, and the associations show gender differences. Improving the lifestyles of cancer survivors, and controlling and reducing their comorbidities are important for improving their sexual satisfaction. (Source: Cancer Medicine)
Source: Cancer Medicine - July 13, 2021 Category: Cancer & Oncology Authors: Jingya Wang, Jie Zhao, Chenggang Zhang, Yuxin Zhang, Nan Jiang, Xiaomin Wei, Jiwei Wang, Jinming Yu Tags: RESEARCH ARTICLE Source Type: research

Clinicopathologic factors that influence prognosis and survival outcomes in men with metastatic castration ‐resistant prostate cancer treated with Radium‐223
Baseline clinicopathological factors were associated with survival for men with metastatic castration-resistant prostate cancer who were treated with radium-233. Our retrospective analysis defined a prognostic model that can be utilized to evaluate the treatment benefit of radium-223. AbstractBackgroundIn men with metastatic castration-resistant prostate cancer (mCRPC) with primarily bone metastases, radium-223 (223Ra) improves overall survival (OS). However, the selection of223Ra is not guided by specific validated clinicopathologic factors, and thus outcomes are heterogeneous.Patients and methodsThis retrospective surviv...
Source: Cancer Medicine - July 13, 2021 Category: Cancer & Oncology Authors: Esmail M. Al ‐Ezzi, Husam A. Alqaisi, Marco A. J. Iafolla, Lisa Wang, Srikala S. Sridhar, Adrian G. Sacher, Nazanin Fallah‐Rad, Di M. Jiang, Geoffrey A. Watson, Charles N. Catton, Padraig R. Warde, Rob J. Hamilton, Neil E. Fleshner, Alexa Tags: RESEARCH ARTICLE Source Type: research

The role of sex and rurality in cancer fatalistic beliefs and cancer screening utilization in Florida
ConclusionsSome, but not all, cancer fatalistic beliefs are associated with getting breast and colorectal cancer screening in north-central Florida. Our study highlights the need for more research to better understand the social and cultural factors associated with cancer screening utilization. (Source: Cancer Medicine)
Source: Cancer Medicine - July 13, 2021 Category: Cancer & Oncology Authors: Yi Guo, Sarah M. Szurek, Jiang Bian, Dejana Braithwaite, Jonathan D. Licht, Elizabeth A. Shenkman Tags: ORIGINAL RESEARCH Source Type: research

Antibiotic use influences outcomes in advanced pancreatic adenocarcinoma patients
AbstractRecent studies defined a potentially important role of the microbiome in modulating pancreatic ductal adenocarcinoma (PDAC) and responses to therapies. We hypothesized that antibiotic usage may predict outcomes in patients with PDAC.We retrospectively analyzed clinical data of patients with resectable or metastatic PDAC seen at MD Anderson Cancer from 2003 to 2017. Demographic, chemotherapy regimen and antibiotic use, duration, type, and reason for indication were recorded.A total of 580 patients with PDAC were studied, 342 resected and 238 metastatic patients, selected retrospectively from our database. Antibiotic...
Source: Cancer Medicine - July 12, 2021 Category: Cancer & Oncology Authors: Chirayu Mohindroo, Merve Hasanov, Jane E. Rogers, Wenli Dong, Laura R. Prakash, Seyda Baydogan, Jonathan D. Mizrahi, Michael J. Overman, Gauri R. Varadhachary, Robert A. Wolff, Milind M. Javle, David R. Fogelman, Michael T. Lotze, Michael P. Tags: RESEARCH ARTICLE Source Type: research

Identification of novel mutations and functional impacts of EPAS1 in colorectal cancer
The novel findings of EPAS1 mutation in cancer tissues from colon cancer might be involved in carcinogenesis. Thus, the molecular and functional studies implied that EPAS1 plays crucial roles in CRC pathogenesis and have the potential to be used as a prognostic marker and as a therapeutic target. AbstractEndothelial PAS domain-containing protein 1 (EPAS1) has implications in many cancers. However, the molecular behaviours, functional roles and mutational status ofEPAS1 have never been studied in colorectal carcinoma (CRC). The study aims to examine the genetic alterations and functional roles ofEPAS1 in CRC. In addition, t...
Source: Cancer Medicine - July 12, 2021 Category: Cancer & Oncology Authors: Farhadul Islam, Vinod Gopalan, Cu Tai Lu, Suja Pillai, Alfred K. Lam Tags: ORIGINAL RESEARCH Source Type: research

Hypoxia ‐related lncRNAs to build prognostic classifier and reveal the immune characteristics of EGFR wild type and low expression of PD‐L1 squamous and adenocarcinoma NSCLC
ConclusionsIt is noteworthy that hypolncRNAs are associated with the survival of double-negative LUAD and LUSC patients, for which the possible mechanism is inhibiting the antitumor immune process. (Source: Cancer Medicine)
Source: Cancer Medicine - July 12, 2021 Category: Cancer & Oncology Authors: Fang Zhao, Min Wang, Jie Zhu Tags: ORIGINAL RESEARCH Source Type: research

Diagnostic and prognostic value of stem cell factor plasma level in glioblastoma multiforme patients
This study suggests that measurement of the SCF plasma level can aid in GBM patient's management for diagnostic purposes and as an efficient diagnostic plasma biomarker in patients with a new brain mass to differentiate between glioblastoma and nonglial tumors. However, this plasma biomarker does not exhibit prognostic value. AbstractBackgroundInvestigation of novel blood-circulating agents as potential biomarkers for glioblastoma multiforme (GBM) patients ’ diagnosis and monitoring has gained lots of attention, due to limitations of imaging modalities and invasive tissue biopsy procedures. The present study aims to ...
Source: Cancer Medicine - July 12, 2021 Category: Cancer & Oncology Authors: Amirhosein Kefayat, Alireza Amouheidari, Fatemeh Ghahremani, Zahra Alirezaei Tags: ORIGINAL RESEARCH Source Type: research

Cardiotoxicity screening of long ‐term, breast cancer survivors—The CAROLE (Cardiac‐Related Oncologic Late Effects) Study
ConclusionThis study identified a high incidence of CVD in heterogenous long-term breast cancer survivors, most>10  years post-treatment. Over half had clinical CVD findings warranting follow-up and/or intervention. Each imaging test independently contributed to the detection rate. This provides early evidence that long-term cardiac screening may be of value to a wider group of breast cancer survivors than prev iously recognized. (Source: Cancer Medicine)
Source: Cancer Medicine - July 10, 2021 Category: Cancer & Oncology Authors: Lindsay L. Puckett, Shahryar G. Saba, Sonia Henry, Stacey Rosen, Elise Rooney, Samaria L. Filosa, Philip Gilbo, Karalyn Pappas, Alison Laxer, Katherine Eacobacci, Amitha N. Kapyur, Justin Robeny, Samantha Musial, Anisha Chaudhry, Rahul Chaud Tags: ORIGINAL RESEARCH Source Type: research

Gamma ‐synuclein is a novel prognostic marker that promotes tumor cell migration in biliary tract carcinoma
In conclusion, SNCG may promote tumor cell activity and is potentially a novel prognostic marker in BTC. (Source: Cancer Medicine)
Source: Cancer Medicine - July 10, 2021 Category: Cancer & Oncology Authors: Yusuke Takemura, Hidenori Ojima, Go Oshima, Masahiro Shinoda, Yasushi Hasegawa, Minoru Kitago, Hiroshi Yagi, Yuta Abe, Shutaro Hori, Yoko Fujii ‐Nishimura, Naoto Kubota, Yuki Masuda, Taizo Hibi, Michiie Sakamoto, Yuko Kitagawa Tags: ORIGINAL RESEARCH Source Type: research

Overexpression of claspin promotes docetaxel resistance and is associated with prostate ‐specific antigen recurrence in prostate cancer
Claspin overexpression was related to poor PSA relapse-free prognosis. Claspin knockdown significantly upregulated the sensitivity to docetaxel in DU145 docetaxel-resistant cells. AbstractAlthough docetaxel (DTX) confers significant survival benefits in patients with castration-resistant prostate cancer (CRPC), resistance to DTX inevitably occurs. Therefore, clarifying the mechanisms of DTX resistance may improve survival in patients with CRPC. Claspin plays a pivotal role in DNA replication stress and damage responses and is an essential regulator for the S-phase checkpoint.CLSPN is an oncogenic gene that contributes to t...
Source: Cancer Medicine - July 9, 2021 Category: Cancer & Oncology Authors: Takashi Babasaki, Kazuhiro Sentani, Yohei Sekino, Go Kobayashi, Quoc Thang Pham, Narutaka Katsuya, Shintaro Akabane, Daiki Taniyama, Tetsutaro Hayashi, Masaki Shiota, Naohide Oue, Jun Teishima, Akio Matsubara, Wataru Yasui Tags: ORIGINAL RESEARCH Source Type: research

The prognostic performance of the log odds of positive lymph nodes in patients with esophageal squamous cell carcinoma: A population study of the US SEER database and a Chinese single ‐institution cohort
The LODDS classification showed a better prognostic performance than the traditional N or LNR stages in patients with ESCC. LODDS can serve as an auxiliary factor to improve prognostic performance and can be applied in the evaluation of lymph node status. AbstractBackgroundThe purpose of this study was to assess the prognostic performance of the log odds of positive lymph nodes (LODDS) value compared with the pathological N stage and lymph node ratio (LNR) in patients with esophageal squamous cell carcinoma (ESCC).MethodIn total 1144 patients diagnosed with ESCC from the Surveillance, Epidemiology, and End Results (SEER) d...
Source: Cancer Medicine - July 9, 2021 Category: Cancer & Oncology Authors: Hongdian Zhang, Wanyi Xiao, Peng Ren, Kai Zhu, Ran Jia, Yueyang Yang, Lei Gong, Zhentao Yu, Peng Tang Tags: ORIGINAL RESEARCH Source Type: research

Development and validation of a nomogram based on stromal score to predict progression ‐free survival of patients with papillary thyroid carcinoma
ConclusionHigh stromal score was significantly associated with improved PFS in patients with PTC. The nomogram based on the stromal score and clinicopathological patterns yielded a reliable performance to predict the prognosis of PTC. (Source: Cancer Medicine)
Source: Cancer Medicine - July 9, 2021 Category: Cancer & Oncology Authors: Jiajia Tang, Shitao Jiang, Qiong Gao, Xuehua Xi, Luying Gao, Ruina Zhao, Xingjian Lai, Bo Zhang, Yuxin Jiang Tags: ORIGINAL RESEARCH Source Type: research

Establishment of patient ‐derived organotypic tumor spheroid models for tumor microenvironment modeling
As stated in the manuscript, we established and characterized a series of colorectal cancer PDOTS models for use as a preclinical platform for testing effective immunotherapy and its combinations with other drugs. PDOTSs from tumors from a high-level microsatellite instability-harboring patient were sensitive to anti-PD-1 or anti-PD-L1 antibodies. Our results demonstrate that the PDOTS model in which the tumor immune microenvironment is preserved may represent an advantageous ex vivo system to develop effective immune therapeutics. AbstractPatient-derived cancer models that reconstitute the characteristics of the tumor mic...
Source: Cancer Medicine - July 9, 2021 Category: Cancer & Oncology Authors: Hye Kyung Hong, Nak Hyeon Yun, Ye ‐Lin Jeong, Jeehun Park, Junsang Doh, Woo Yong Lee, Yong Beom Cho Tags: ORIGINAL RESAERCH Source Type: research

Issue Information
(Source: Cancer Medicine)
Source: Cancer Medicine - July 9, 2021 Category: Cancer & Oncology Tags: ISSUE INFORMATION Source Type: research

Prevalence, trends, and outcomes of atrial fibrillation in hospitalized patients with metastatic cancer: findings from a national sample
This study aims to evaluate the prevalence, temporal trends, and outcomes of AF in hospitalized metastatic cancer patients.MethodsThe National Inpatient Sample (NIS) database was used to identify adult patients with metastatic tumors from 2003 to 2014. We analyzed the trends in AF prevalence, in-hospital mortality, total cost, length of stay (LOS), and comorbidities pertaining to metastatic cancer. Multivariable-adjusted models were used to evaluate the association of AF with clinical factors, in-hospital mortality, total cost, and LOS.ResultsAmong 2,478,598 patients with metastatic cancer, 8.74% (216,737) were diagnosed w...
Source: Cancer Medicine - July 8, 2021 Category: Cancer & Oncology Authors: Hedong Han, Longpei Chen, Zhen Lin, Xin Wei, Wei Guo, Yamei Yu, Cheng Wu, Yang Cao, Jia He Tags: ORIGINAL RESEARCH Source Type: research

Abnormal expression and methylation of PRR34 ‐AS1 are associated with adverse outcomes in acute myeloid leukemia
In summary, the findings of this study show that high PRR34-AS1 expression may be associated with poor chemotherapeutic efficacy and poor prognosis in AML patients. In addition, higher expression of PRR34-AS1 was associated with the hypomethylation of its promoter, and hypomethylation of PRR34-AS1  may affect the prognosis of AML patients. AbstractIt was previously reported thatPRR34-AS1 was overexpressed in some solid tumors.PRR34-AS1 promoter was shown to have a differential methylation region (DMR), and was hypomethylated in acute myeloid leukemia (AML). Therefore, the present study used real-time quantitative PCR ...
Source: Cancer Medicine - July 6, 2021 Category: Cancer & Oncology Authors: Fang ‐yu Nan, Yu Gu, Zi‐jun Xu, Guo‐kang Sun, Jing‐dong Zhou, Ting‐juan Zhang, Ji‐chun Ma, Jia‐yan Leng, Jiang Lin, Jun Qian Tags: ORIGINAL RESEARCH Source Type: research

Expression of 5 ‐methylcytosine regulators is highly associated with the clinical phenotypes of prostate cancer and DNMTs expression predicts biochemical recurrence
DNA methyltransferases (DNMTs) are strongly associated with pathologic phenotypes and immune infiltration patterns in PCa. We built a two-factor predictive model using the expression features of DNMT3B and DNMT1. The model was used to predict the BCR status of patients with PCa and achieved area under the receiver operating characteristic curve values of 0.70 and 0.88 in the training and independent testing datasets, respectively. AbstractIn patients with prostate cancer (PCa), there is a high rate of overdiagnosis and frequent overtreatment. Therefore, there is an urgent need for more accurate prediction of biochemical re...
Source: Cancer Medicine - July 6, 2021 Category: Cancer & Oncology Authors: Lin Wang, Guoping Ren, Biaoyang Lin Tags: ORIGINAL RESEARCH Source Type: research

International perspectives on suboptimal patient ‐reported outcome trial design and reporting in cancer clinical trials: A qualitative study
ConclusionMisconceptions relating to PRO methodology and its use may undermine their planning, collection, and reporting. There is a role for funding, regulatory, methodological, and journalistic institutions to address perceptions around the value of PROs, their position within the trial outcomes hierarchy, that PRO training and guidance is available, signposted, and readily accessible, with accompanying measures to ensure compliance with international best practice guidelines. (Source: Cancer Medicine)
Source: Cancer Medicine - July 5, 2021 Category: Cancer & Oncology Authors: Ameeta Retzer, Melanie Calvert, Khaled Ahmed, Thomas Keeley, Jo Armes, Julia M. Brown, Lynn Calman, Anna Gavin, Adam W. Glaser, Diana M. Greenfield, Anne Lanceley, Rachel M. Taylor, Galina Velikova, Michael Brundage, Fabio Efficace, Rebecca Tags: ORIGINAL RESEARCH Source Type: research

Long non ‐coding RNA HULC stimulates the epithelial–mesenchymal transition process and vasculogenic mimicry in human glioblastoma
ConclusionLncRNA HULC stimulates the EMT process and VM in human GBM, and may be a therapeutic target for intervention of GBM. (Source: Cancer Medicine)
Source: Cancer Medicine - July 2, 2021 Category: Cancer & Oncology Authors: Tiantian Yin, Jing Wu, Yuchen Hu, Min Zhang, Jie He Tags: ORIGINAL RESEARCH Source Type: research

Yoga for cancer survivors with chemotherapy ‐induced peripheral neuropathy: Health‐related quality of life outcomes
ConclusionsYoga may reduce anxiety in patients with CIPN. Future studies are needed to confirm these findings.Clinical Trial Registration Number: ClinicalTrials.gov Identifier: NCT03292328. (Source: Cancer Medicine)
Source: Cancer Medicine - July 2, 2021 Category: Cancer & Oncology Authors: W. Iris Zhi, Raymond E. Baser, Lillian M. Zhi, Dristi Talukder, Qing S. Li, Tina Paul, Clare Patterson, Lauren Piulson, Christina Seluzicki, Mary L. Galantino, Ting Bao Tags: ORIGINAL RESEARCH Source Type: research