Local delivery of dinutuximab from lyophilized silk fibroin foams for treatment of an orthotopic neuroblastoma model
Dinutuximab, an immunotherapy targeting GD2, was delivered loacally in a lyophilized silk fibroin foam for the treatment of an orthotopic neuroblastoma mouse model. Silk fibroin foam allows for a sustained release of dinutuximab, causing significant tumor growth inhibition. AbstractImmunotherapy targeting GD2 is a primary treatment for patients with high ‐risk neuroblastoma. Dinutuximab is a monoclonal antibody with great clinical promise but is limited by side effects such as severe pain. Local delivery has emerged as a potential mechanism to deliver higher doses of therapeutics into the tumor bed, while limiting system...
Source: Cancer Medicine - February 28, 2020 Category: Cancer & Oncology Authors: Kimberly J. Ornell, Jordan S. Taylor, Jasmine Zeki, Naohiko Ikegaki, Hiroyuki Shimada, Jeannine M. Coburn, Bill Chiu Tags: ORIGINAL RESEARCH Source Type: research

Discovery of novel molecular characteristics and cellular biological properties in ameloblastoma
In this study, we sought to uncover the molecular basis of ameloblastoma and to determine the cellular phenotype of ameloblastoma cells withBRAF mutations. Our comparative cDNA microarray analysis and gene set enrichment analysis (GSEA) showed that ameloblastoma exhibited a distinct gene expression pattern from the normal tissues: KRAS ‐responsive gene set is significantly activated in ameloblastoma. Importantly,insulin like growth factor 2 (IGF2), a member of KRAS ‐responsive genes, enhances the proliferation of an ameloblastoma cell line AMU‐AM1 withBRAF mutation. In addition, Toll ‐like receptor 2 (TLR2) knockdo...
Source: Cancer Medicine - February 28, 2020 Category: Cancer & Oncology Authors: Sayuri Kondo, Akinobu Ota, Takayuki Ono, Sivasundaram Karnan, Md Wahiduzzaman, Toshinori Hyodo, Md Lutfur Rahman, Kunihiro Ito, Akifumi Furuhashi, Tomio Hayashi, Hiroyuki Konishi, Shinobu Tsuzuki, Yoshitaka Hosokawa, Yoshiaki Kazaoka Tags: ORIGINAL RESEARCH Source Type: research

CD66b+ neutrophils and α‐SMA+ fibroblasts predict clinical outcomes and benefits from postoperative chemotherapy in gastric adenocarcinoma
We concluded that the combination of CD66b+ tumor ‐associated neutrophils and α‐SMA+ cancer ‐associated fibroblasts could be used as an independent factor of outcome and to identify those gastric adenocarcinoma patients who might obtain advantage from postoperative chemotherapeutics. AbstractBackgroundEmerging evidence indicates that the tumor microenvironment (TME) influences tumor progression through the various cells it contains. Tumor ‐associated neutrophils (TANs) and cancer‐associated fibroblasts (CAFs) are prominent constituents of diverse malignant solid tumors and are crucial in the TME and cancer ...
Source: Cancer Medicine - February 28, 2020 Category: Cancer & Oncology Authors: Xiliang Cong, Yongle Zhang, Ziyu Zhu, Sen Li, Xin Yin, Zhao Zhai, Yu Zhang, Yingwei Xue Tags: ORIGINAL RESEARCH Source Type: research

An immune relevant signature for predicting prognoses and immunotherapeutic responses in patients with muscle ‐invasive bladder cancer (MIBC)
In this study, we computed the relative abundances of 24 immune cells based on the expression profiles of MIBC patients using single ‐sample gene set enrichment analysis (ssGSEA). Unsupervised clustering analysis of the 24 immune cells was performed to classify MIBC patients into different immune‐infiltrating groups. Genome (gene mutation and copy number variation), transcriptome (mRNA, lncRNA, and miRNA), and functional enri chment were found to be heterogeneous among different immune‐infiltrating groups. We identified 282 differentially expressed genes (DEGs) associated with immune infiltration by comparing the exp...
Source: Cancer Medicine - February 28, 2020 Category: Cancer & Oncology Authors: Wen Jiang, Dandan Zhu, Chenghe Wang, Yu Zhu Tags: ORIGINAL RESEARCH Source Type: research

Nomograms to predict the long ‐time prognosis in patients with alpha‐fetoprotein negative hepatocellular carcinoma following radical resection
About 30% of HCC patients showed negative serum AFP and had special clinicopathologic characteristics and prognosis. We developed and validated nomograms for predicting prognosis of patients with AFP ‐negative HCC after radical resection. Our novel nomograms presented superior performance and discrimination ability than conventional staging systems based on the C‐indexes, calibration curves, decision curve analysis and Kaplan‐Meier curves, which were proposed for clinical decision. AbstractBackgroundTo develop and validate nomograms that can be used to predict outcomes in individuals suffering alpha ‐fetoprotein (A...
Source: Cancer Medicine - February 28, 2020 Category: Cancer & Oncology Authors: Jian Huang, Fu ‐Chen Liu, Li Li, Wei‐Ping Zhou, Bei‐Ge Jiang, Ze‐Ya Pan Tags: ORIGINAL RESEARCH Source Type: research

Integrated bioinformatics analysis of the crucial candidate genes and pathways associated with glucocorticoid resistance in acute lymphoblastic leukemia
In this study, we used bioinformatic analysis methods to integrate the candidate genes and pathways participating in GC resistance in ALL and subsequently verified the bioinformatics findings with in vitro cell experiments. Ninety ‐nine significant common differentially expressed genes (DEGs) associated with GC resistance were determined by integrating two gene profile datasets, including GC‐sensitive and ‐resistant samples. Using Kyoto Encyclopedia of Genes and Genomes (KEGG) and REACTOME pathways analysis, the signali ng pathways in which DEGs were significantly enriched were clustered. The GC resistance‐related ...
Source: Cancer Medicine - February 28, 2020 Category: Cancer & Oncology Authors: Yanxin Chen, Peifang Jiang, Jingjing Wen, Zhengjun Wu, Jiazheng Li, Yuwen Chen, Lingyan Wang, Donghui Gan, Yingyu Chen, Ting Yang, Minhui Lin, Jianda Hu Tags: ORIGINAL RESEARCH Source Type: research

Treatment times in breast cancer patients receiving neoadjuvant vs adjuvant chemotherapy: Is efficiency a benefit of preoperative chemotherapy?
This study evaluated the time to initiation and completion of treatment in breast cancer patients undergoing neoadjuvant chemotherapy (NAC) vs adjuvant chemotherapy. We found that NAC did not expedite the start or completion of treatment. AbstractBackground/ObjectiveDelays in times to surgery, chemotherapy, and radiotherapy impair survival in breast cancer patients. Neoadjuvant chemotherapy (NAC) confers equivalent survival to adjuvant chemotherapy (AC), but it remains unknown which approach facilitates faster initiation and completion of treatment.MethodsWomen ≥18 years old with nonrecurrent, noninflammatory, clin...
Source: Cancer Medicine - February 28, 2020 Category: Cancer & Oncology Authors: Nicole M. Melchior, Darren B. Sachs, Gabrielle Gauvin, Cecilia Chang, Chihsiung E. Wang, Elin R. Sigurdson, John M. Daly, Allison A. Aggon, Shelly B. Hayes, Elias I. Obeid, Richard J. Bleicher Tags: ORIGINAL RESEARCH Source Type: research

Novel risk group stratification for metastatic urothelial cancer patients treated with immune checkpoint inhibitors
Novel Emory risk scoring system may predict clinical outcomes in urothelial cancer patients receiving immunotherapy. Increased baseline PLR, low baseline albumin, metastasis to the liver, and higher ECOG PS associated with decreased survival. AbstractBackgroundWe developed a novel risk scoring system for urothelial cancer (UC) patients receiving immune checkpoint inhibitors (ICI).MethodsWe conducted a retrospective review of 67 UC patients treated with ICI at Winship Cancer Institute of Emory University from 2015 to 2018. Using stepwise variable selection in Cox proportional hazard model and Sullivan's weighting schema, ba...
Source: Cancer Medicine - February 28, 2020 Category: Cancer & Oncology Authors: Julie M. Shabto, Dylan J. Martini, Yuan Liu, Deepak Ravindranathan, Jacqueline Brown, Emilie E. Hitron, Greta A. Russler, Sarah Caulfield, Haydn Kissick, Mehrdad Alemozaffar, Kenneth Ogan, Wayne B. Harris, Viraj A. Master, Omer Kucuk, Bradle Tags: ORIGINAL RESEARCH Source Type: research

Postoperative intensity ‐modulated radiation therapy reduces local recurrence and improves overall survival in III‐N2 non‐small‐cell lung cancer: A single‐center, retrospective study
ConclusionPORT remarkably reduced local recurrence and improved OS in stage III ‐pN2 NSCLC, especially in the multiple‐station pN2 group. (Source: Cancer Medicine)
Source: Cancer Medicine - February 28, 2020 Category: Cancer & Oncology Authors: Wei Wei, Jiao Zhou, Qun Zhang, De ‐Hua Liao, Qiao‐Dan Liu, Bei‐Long Zhong, Zi‐Bin Liang, Yong‐Chang Zhang, Rong Jiang, Gui‐Yun Liu, Chen‐Yang Xu, Huai‐ Li Zhou, Su‐Yu Zhu, Nong Yang, Wen Jiang, Zhi‐Gang Liu Tags: ORIGINAL RESEARCH Source Type: research

Sequential boost of intensity ‐modulated radiotherapy with chemotherapy for inoperable esophageal squamous cell carcinoma: A prospective phase II study
ConclusionsSequential boost to 66  Gy by IMRT with chemotherapy was safe and effective for inoperable ESCC. A randomized phase III study to compare with standard dose of 50 Gy is warranted. (Source: Cancer Medicine)
Source: Cancer Medicine - February 28, 2020 Category: Cancer & Oncology Authors: Xing ‐Wen Fan, Hong‐Bing Wang, Jing‐Fang Mao, Ling Li, Kai‐Liang Wu Tags: ORIGINAL RESEARCH Source Type: research

Expression of human Kr üppel‐like factor 3 in peripheral blood as a promising biomarker for acute leukemia
In the present study, we investigated the expression of hKLF3 in acute leukemia patients by both Sanger sequencing and RT ‐qPCR. ROC analyses indicated excellent efficacy of hKLF3 expression in PB samples for the diagnosis of AML. In addition, a significantly converse correlation between inhibition of hKLF3 expression in peripheral blood and increased leukemic burden was observed. AbstractBackgroundUniversal gene targets are in persistent demand by real ‐time quantitative polymerase chain reaction (RT‐qPCR)‐based methods in acute leukemia (AL) diagnosis and monitoring. Human Krüppel‐like factor 3 (hKLF3), a ...
Source: Cancer Medicine - February 28, 2020 Category: Cancer & Oncology Authors: Miao Yan, Huihui Liu, Junhui Xu, Xinan Cen, Qian Wang, Weilin Xu, Wensheng Wang, Zhixiang Qiu, Jinping Ou, Yujun Dong, Ping Zhu, Hanyun Ren, Fuchu He, Mangju Wang Tags: ORIGINAL RESEARCH Source Type: research

LncRNA growth arrest ‐specific transcript 5 targets miR‐21 gene and regulates bladder cancer cell proliferation and apoptosis through PTEN
In bladder cancer, the expression level of growth arrest ‐specific transcript 5 (GAS5) was decreased and the expression level of miR‐21 was elevated, and high levels of GAS5 and low levels of miR‐21 might be associated with higher survival. MiR‐21 was a target of GAS5, and PTEN was a target gene of miR‐21. GAS5 could inhibit the proliferation of bladder cancer cells and promote apoptosis by regulating PTEN through miR‐21. AbstractThe aim of this study was to investigate the mechanism by which growth arrest ‐specific transcript 5 (GAS5) regulates bladder cancer cells. Bladder cancer samples were collected and ...
Source: Cancer Medicine - February 25, 2020 Category: Cancer & Oncology Authors: Dong Chen, Yihong Guo, Yaqiu Chen, Qiaonan Guo, Junyi Chen, Yining Li, Qiuping Zheng, Minyao Jiang, Ming Xi, Lu Cheng Tags: ORIGINAL RESEARCH Source Type: research

Postoperative adjuvant therapy following radical resection for intrahepatic cholangiocarcinoma: A multicenter retrospective study
ConclusionWith the current data, we conclude that AT benefits ICC patients following radical resection, especially those “middle‐risk” patients, as evaluated by the established nomogram. However, exactly which patients are the most suitable for AT requires further study and validation. (Source: Cancer Medicine)
Source: Cancer Medicine - February 25, 2020 Category: Cancer & Oncology Authors: Lei Wang, Manjun Deng, Qiao Ke, Jianying Lou, Shuguo Zheng, Xinyu Bi, Jianming Wang, Wei Guo, Fuyu Li, Jian Wang, Yamin Zheng, Jingdong Li, Shi Cheng, Weiping Zhou, Yongyi Zeng Tags: ORIGINAL RESEARCH Source Type: research

Experimental study of the vascular normalization window for tumors treated with apatinib and the efficacy of sequential chemotherapy with apatinib in lung cancer ‐bearing mice and patients
In this study, we constructed a nude mouse xenograft model of lung cancer and administered apatinib at different doses and times to detect the normalization of reactive blood vessels through VEGF, α‐SMA, college‐ IV, HIF‐1α, and MMP. The ultrastructure of tumor blood vessels was observed by electron microscopy, and the dose and timing of apatinib‐induced normalization of lung cancer in nude mice were confirmed. Then, we observed the inhibitory effect of apatinib combined with pemetrexed on transplanted tumors of lung cancer cells in nude mice at different time points and observed whether combination pem...
Source: Cancer Medicine - February 25, 2020 Category: Cancer & Oncology Authors: Mingtao Liu, Hui Li, Xiuxiu Wang, Lijun Jing, Peng Jiang, Yu Li Tags: ORIGINAL RESEARCH Source Type: research

Distinctive lung cancer incidence trends among men and women attributable to the period effect in Shanghai: An analysis spanning 42  years
ConclusionsThe distinctive patterns of lung cancer incidence between men and women may be attributable to significant period effects, which reflected the changes in public health policies or diagnostic practices and highlighted the urgent of continued monitoring of gender ‐specific risk factors for lung cancer incidence. (Source: Cancer Medicine)
Source: Cancer Medicine - February 25, 2020 Category: Cancer & Oncology Authors: Li Xie, Ying Qian, Yishan Liu, Yixuan Li, Sinong Jia, Herbert Yu, Chunfang Wang, Biyun Qian, Pingping Bao Tags: ORIGINAL RESEARCH Source Type: research

Contrast ‐enhanced spectral mammography: A potential exclusion diagnosis modality in dense breast patients
China has an increasing burden of breast cancer, but with a population of dense breast patients, the diagnostic efficiency of conventional digital mammography was attenuated. Our study suggested that CESM exhibited an excellent diagnostic efficiency and a moderate correlation in lesion size estimation compared to DCE ‐MRI and pathology, supporting it to be an alternative to DCE‐MRI in breast cancer detection and diagnosis, especially for exclusion diagnosis in dense breast patients. AbstractBackgroundChina has an increasing burden of breast cancer. However, with a large population of dense breast patients, the diagnost...
Source: Cancer Medicine - February 25, 2020 Category: Cancer & Oncology Authors: Yun Qin, Ying Liu, Xueqin Zhang, Shuang Zhao, Huanhuan Zhong, Juan Huang, Jianqun Yu Tags: ORIGINAL RESEARCH Source Type: research

Evidence of pseudoprogression in patients treated with PD1/PDL1 antibodies across tumor types
ConclusionsA small subset of PSPD patients may experience response after an initial progression. Assessment of the current strategy for immune ‐related response evaluations may require further attention. (Source: Cancer Medicine)
Source: Cancer Medicine - February 25, 2020 Category: Cancer & Oncology Authors: Patricia Martin ‐Romano, Eduardo Castanon, Samy Ammari, Stéphane Champiat, Antoine Hollebecque, Sophie Postel‐Vinay, Capucine Baldini, Andrea Varga, Jean Marie Michot, Perrine Vuagnat, Aurélien Marabelle, Jean‐Charles Soria, Charles Fe Tags: ORIGINAL RESEARCH Source Type: research

Epithelial ‐mesenchymal transition may be involved in the immune evasion of circulating gastric tumor cells via downregulation of ULBP1
ConclusionsOur study indicated that EMT might play a vital role in the immune invasion of CTCs by regulating the expression of ULBP1 on CTCs. These findings could provide potential strategies for targeting the immune evasion capacity of CTCs. (Source: Cancer Medicine)
Source: Cancer Medicine - February 25, 2020 Category: Cancer & Oncology Authors: Baoguang Hu, Xiaokun Tian, Yanbin Li, Yangchun Liu, Tao Yang, Zhaodong Han, Jiajia An, Lingqun Kong, Yuming Li Tags: ORIGINAL RESEARCH Source Type: research

Prognostic nomograms and Aggtrmmns scoring system for predicting overall survival and cancer ‐specific survival of patients with kidney cancer
ConclusionThe nomogram and Aggtrmmns scoring system can predict OS and CSS in kidney cancer patients effectively, which may help clinicians personalize prognostic assessments and clinical decisions. (Source: Cancer Medicine)
Source: Cancer Medicine - February 25, 2020 Category: Cancer & Oncology Authors: Yuan Zhou, Rentao Zhang, Yinman Ding, Zhengquan Wang, Cheng Yang, Sha Tao, Chaozhao Liang Tags: ORIGINAL RESEARCH Source Type: research

Integrative clinical and biopathology analyses to understand the clinical heterogeneity of infantile rhabdomyosarcoma: A report from the French MMT committee
ConclusionsBiopathology findings from this study support the different prognosis of infantile RMS. New fusion ‐positive SRMS has a very good outcome which may allow more conservative treatment in the future. (Source: Cancer Medicine)
Source: Cancer Medicine - February 25, 2020 Category: Cancer & Oncology Authors: Thibault Butel, Marie Karanian, Gaelle Pierron, Daniel Orbach, Dominique Ranchere, Nathalie Cozic, Louise Galmiche, Aurore Coulomb, Nad ège Corradini, Brigitte Lacour, Stéphanie Proust, Florent Guerin, Hélène Boutroux, Angélique Rome, L Tags: ORIGINAL RESEARCH Source Type: research

Cost ‐effectiveness of the Collaborative Care to Preserve Performance in Cancer (COPE) trial tele‐rehabilitation interventions for patients with advanced cancers
ConclusionThe delivery of a CCM ‐based, centralized tele‐rehabilitation intervention to patients with advanced stage cancer is highly cost‐effective. Clinicians and care teams working with this vulnerable population should consider incorporating such interventions into their patient care plans. (Source: Cancer Medicine)
Source: Cancer Medicine - February 25, 2020 Category: Cancer & Oncology Authors: Colleen F. Longacre, John A. Nyman, Sue L. Visscher, Bijan J. Borah, Andrea L. Cheville Tags: ORIGINAL RESEARCH Source Type: research

Effects of oral maintenance chemotherapy and predictive value of circulating EBV DNA in metastatic nasopharyngeal carcinoma
ConclusionsOral maintenance chemotherapy with S1 or capecitabine can improve OS in mNPC. Posttreatment EBV ‐DNA was not only an independent prognosis factor for mNPC but also can screen out beneficiaries of maintenance chemotherapy. (Source: Cancer Medicine)
Source: Cancer Medicine - February 25, 2020 Category: Cancer & Oncology Authors: Han Zhou, Tianzhu Lu, Qiaojuan Guo, Yan Chen, Mengwei Chen, Yansong Chen, Yingying Lin, Chuanben Chen, Liqin Ma, Yun Xu, Shaojun Lin, Jianji Pan Tags: ORIGINAL RESEARCH Source Type: research

Clinicopathological significance of microRNA ‐21 in extracellular vesicles of pleural lavage fluid of lung adenocarcinoma and its functions inducing the mesothelial to mesenchymal transition
ConclusionsEV ‐miR‐21 in pleural lavage fluid is important as a diagnostic and prognostic factor. Moreover, EV‐miR‐21 induces the MMT, which can form premetastatic niches of dissemination in the pleural cavity. (Source: Cancer Medicine)
Source: Cancer Medicine - February 25, 2020 Category: Cancer & Oncology Authors: Shiori Watabe, Yoshinao Kikuchi, Shigeki Morita, Daisuke Komura, Satoe Numakura, Arisa Kumagai ‐Togashi, Masato Watanabe, Noriyuki Matsutani, Masafumi Kawamura, Masanori Yasuda, Hiroshi Uozaki Tags: ORIGINAL RESEARCH Source Type: research

Effect of anlotinib as a third ‐ or further‐line therapy in advanced non‐small cell lung cancer patients with different histologic types: Subgroup analysis in the ALTER0303 trial
In this study, we evaluated the efficacy of anlotinib as third ‐ or further‐line treatment for patient with different histological types of NSCLC. In the ALTER0303 trial, 336 patients had the histological subtype of adenocarcinoma (ACC), 86 patients had the histological subtype of squamous cell carcinoma (SCC), and 15 patients had another subtype. Our findi ngs suggest that anlotinib significantly improves PFS and OS in ACC patients and has a tendency to prolong survival in SCC patients. AbstractBackgroundAnlotinib showed significant survival benefits in advanced non ‐small cell lung cancer (NSCLC) patients as a thir...
Source: Cancer Medicine - February 19, 2020 Category: Cancer & Oncology Authors: Ying Cheng, Baohui Han, Kai Li, Qiming Wang, Li Zhang, Jianhua Shi, Zhehai Wang, Jianxing He, Yuankai Shi, Weiqiang Chen, Xiuwen Wang, Yi Luo, Kejun Nan, Faguang Jin, Baolan Li, Jing Zhu Tags: ORIGINAL RESEARCH Source Type: research

MicroRNA ‐320a inhibits invasion and metastasis in osteosarcoma by targeting cytoplasmic polyadenylation element‐binding protein 1
In conclusion, our study demonstrates that miR‐320a plays a critical role in osteosarcoma progression and may provide a potential therapeutic target for osteosarcoma. (Source: Cancer Medicine)
Source: Cancer Medicine - February 19, 2020 Category: Cancer & Oncology Authors: Yanlong Wang, Jiyu Yang, Pangtao Chen, Yu Song, Weizheng An, Haoran Zhang, Butegeleqi Butegeleqi, Jinglong Yan Tags: ORIGINAL RESEARCH Source Type: research

Two miRNA prognostic signatures of head and neck squamous cell carcinoma: A bioinformatic analysis based on the TCGA dataset
This study provides us with a new insight that multiple miRNAs can be together used for predicting the prognosis of patients with HNSCC. In order to further confirm the prognostic value of the 2 miRNA signatures, our future research may focus on exploring the relationship between miRNA and genic profile of HNSCC. AbstractMicroRNAs(miRNAs) are maladjusted in multifarious malignant tumor and can be considered as both carcinogens and tumor ‐inhibiting factor. In the present study, we analyzed the miRNAs expression profiles and clinical information of 481 patients with head and neck squamous cell carcinoma (HNSCC) through th...
Source: Cancer Medicine - February 19, 2020 Category: Cancer & Oncology Authors: Chaoying Wu, Lingxia Tong, Chaoqun Wu, Dong Chen, Jianguo Chen, Qianyun Li, Fang Jia, Zirui Huang Tags: ORIGINAL RESEARCH Source Type: research

A signature of 33 immune ‐related gene pairs predicts clinical outcome in hepatocellular carcinoma
ConclusionOur prognostic signature, which reflects the link between the immune microenvironment and HCC patient outcome, is promising for prognosis prediction in HCC. (Source: Cancer Medicine)
Source: Cancer Medicine - February 19, 2020 Category: Cancer & Oncology Authors: Xiao ‐Yan Sun, Shi‐Zhe Yu, Hua‐Peng Zhang, Jie Li, Wen‐Zhi Guo, Shui‐Jun Zhang Tags: ORIGINAL RESEARCH Source Type: research

METTL3 expression is associated with glycolysis metabolism and sensitivity to glycolytic stress in hepatocellular carcinoma
This article is the first to elucidate the relationship between METTL3 and glycometabolism in hepatocellular carcinoma, which provides new insight into the role of m6A ‐related genes in hepatocellular caricnoma. AbstractMETTL3 is an RNA methyltransferase implicated in the control of cell differentiation and proliferation in embryonic development and cancer. The current study was aimed to explore the function and underlying mechanism of METTL3 in hepatocellular carcinoma (HCC). We evaluated the expression and prognostic significance of METTL3 in 100 HCC cases and TCGA dataset. In HCC cases, both the RNA and protein expres...
Source: Cancer Medicine - February 19, 2020 Category: Cancer & Oncology Authors: Ye Lin, Xiangling Wei, Zhixiang Jian, Xuewen Zhang Tags: ORIGINAL RESEARCH Source Type: research

A phase II study evaluating the role of bortezomib in the management of relapsed acute promyelocytic leukemia treated upfront with arsenic trioxide
The standard ‐of‐care for patients with acute promyelocytic leukemia (APL) relapsing after upfront arsenic trioxide (ATO) therapy is not defined. In this phase II study we demonstrate the safety of adding a proteasome inhibitor with ATO in the management of relapsed APL treated with upfront ATO. We also demo nstrate the efficacy of this combination and the potential for its utilization in this setting. AbstractThe standard ‐of‐care for patients with acute promyelocytic leukemia (APL) relapsing after upfront arsenic trioxide (ATO) therapy is not defined. The present study was undertaken to evaluate the safety of add...
Source: Cancer Medicine - February 15, 2020 Category: Cancer & Oncology Authors: Uday Kulkarni, Saravanan Ganesan, Ansu Abu Alex, Hamenth Palani, Sachin David, Nithya Balasundaram, Arvind Venkatraman, Mani Thenmozhi, Lakshmanan Jeyaseelan, Anu Korula, Anup Devasia, Aby Abraham, Nancy Beryl Janet, Poonkuzhali Balasubramani Tags: ORIGINAL RESEARCH Source Type: research

Impact of delayed treatment in women diagnosed with breast cancer: A population ‐based study
Using national registry data, we studied the effect of delayed treatment on survival in breast cancer patients. We found that extended treatment delay (>90  days postdiagnosis) resulted in worse overall survival in patients with invasive nonmetastatic and metastatic breast cancer but not in patients with noninvasive breast cancer. In addition, delayed adjuvant therapy (>90  days postsurgery) resulted in worse overall survival in patients with invasive nonmetastatic breast cancer who had surgery ≤ 90 days postdiagnosis. AbstractThe impact of timely treatment on breast cancer ‐sp...
Source: Cancer Medicine - February 15, 2020 Category: Cancer & Oncology Authors: Peh Joo Ho, Alex R. Cook, Nur Khaliesah Binte Mohamed Ri, Jenny Liu, Jingmei Li, Mikael Hartman Tags: ORIGINAL RESEARCH Source Type: research

Clinical significance of PET/CT uptake for peripheral clinical N0 non ‐small cell lung cancer
Preoperative SUVmax of primary lesions is a predictor of pathological nodal metastases in peripheral cN0 NSCLC with tumor size  ≤2 cm. Primary tumor SUVmax is associated with key clinicopathological features and prognosis of patients with peripheral cN0 NSCLC with tumor size ≤2 cm. AbstractObjectiveIn this cohort study, we determined the clinical value of the maximum standardized uptake value (SUVmax) of primary tumors in non ‐small cell lung cancer (NSCLC).Study DesignA retrospective review of NSCLC patients was performed from January 2011 to December 2017. Peripheral cN0 NSCLC patients with tu...
Source: Cancer Medicine - February 15, 2020 Category: Cancer & Oncology Authors: Shuai Wang, Dong Lin, Xiaodong Yang, Cheng Zhan, Shihai Zhao, Rongkui Luo, Qun Wang, Lijie Tan Tags: ORIGINAL RESEARCH Source Type: research

Left ventricular ejection fraction decrease related to BRAF and/or MEK inhibitors in metastatic melanoma patients: A retrospective analysis
Left ventricular ejection fraction decreased was observed in 13.6% of patients treated with BRAF and MEK inhibitors. All patients treated with beta ‐blockers and/or angiotensin converting enzyme inhibitors had a normalization of left ventricular ejection fraction. Half of patients with left ventricular ejection fraction decreased had also ophthalmologic adverse event. AbstractBRAF and MEKis have revolutionized the management of BRAFV600‐mutated melanoma patients. Left ventricular ejection fraction decrease (LVEF‐D) related to these treatments has not been thoroughly evaluated to date. The main objective of this study...
Source: Cancer Medicine - February 15, 2020 Category: Cancer & Oncology Authors: Mathilde Berger, Mona Amini ‐Adlé, Delphine Maucort‐Boulch, Philip Robinson, Luc Thomas, Stéphane Dalle, Pierre‐Yves Courand Tags: ORIGINAL RESEARCH Source Type: research

RP11 ‐81H3.2 promotes gastric cancer progression through miR‐339‐HNRNPA1 interaction network
LncRNA RP11 ‐81H3.2 is highly expressed in gastric cancer tissues and cell lines. Knockdown of lncRNA RP11‐81H3.2 suppresses gastric tumor growth in a xenograft tumor model. RP11‐81H3.2/miR‐339/HNRNPA1 interaction network regulates gastric cancer development and progession. AbstractRecent studies have demonstrated that various long non ‐coding RNAs (lncRNAs) participate in the gastric cancer (GC) development and metastasis. Some lncRNAs exert their regulatory function by interacting with microRNAs. Here we identified a novel lncRNA RP11‐81H3.2 that was highly expressed in the GC tissue and cell lines. RP11‐81...
Source: Cancer Medicine - February 13, 2020 Category: Cancer & Oncology Authors: Fen ‐Rong Chen, Su‐Mei Sha, Shen‐Hao Wang, Hai‐Tao Shi, Lei Dong, Dong Liu, Yan Cheng, Miao An, Yan Wang, Jun Zhang Tags: ORIGINAL RESEARCH Source Type: research

LINC00961 inhibits the migration and invasion of colon cancer cells by sponging miR ‐223‐3p and targeting SOX11
This study aimed to explore the potential function and molecular mechanisms of LINC00961 in colon cancer. qPCR results showed that LINC00961 was downregulated in colon cancer cells and tissues. Functional assays demonstrated that LINC00961 suppressed the migration and invasion of colon cancer cells in vitro. LINC00961 functioned as an endogenous sponge for miR ‐223‐3p in colon cancer cells. SOX11 was confirmed as a target gene of miR‐223‐3p. The effect of miR‐223‐3p on colon cancer cells was then investigated. MiR‐223‐3p inhibition enhanced their migration and invasion. The effect of SOX11 on colon cancer c...
Source: Cancer Medicine - February 13, 2020 Category: Cancer & Oncology Authors: Haixia Wu, Yuedi Dai, Dexiang Zhang, Xiaoyu Zhang, Zhiyun He, Xiaojun Xie, Chudong Cai Tags: ORIGINAL RESEARCH Source Type: research

A regional population ‐based hereditary breast cancer screening tool in Italy: First 5‐year results
ConclusionsTo our knowledge, this is the first regional population ‐based multistep model that is aimed to identify individuals withBRCA1/2 mutations and to offer an intensive surveillance program for hereditary ‐high risk women. This tool is feasible and effective, even if more efforts must be performed to increase the acceptance of multiple assessments by the study population. (Source: Cancer Medicine)
Source: Cancer Medicine - February 13, 2020 Category: Cancer & Oncology Authors: Laura Cortesi, Bruna Baldassarri, Stefano Ferretti, Elisabetta Razzaboni, Mariangela Bella, Lauro Bucchi, Debora Canuti, Pierandrea De Iaco, Giorgio De Santis, Fabio Falcini, Vania Galli, Lea Godino, Maurizio Leoni, Anna Myriam Perrone, Marc Tags: ORIGINAL RESEARCH Source Type: research

Cover Image
The cover image is based on the Original ResearchSignificance of concurrent use of weekly cisplatin in carbon ‐ion radiotherapy for locally advanced adenocarcinoma of the uterine cervix: A propensity score‐matched analysis by Noriyuki Okonogi et al.,https://doi.org/10.1002/cam4.2784.Cover image © Noriyuki Okonogi, QST hospital Images. (Source: Cancer Medicine)
Source: Cancer Medicine - February 13, 2020 Category: Cancer & Oncology Authors: Noriyuki Okonogi, Masaru Wakatsuki, Shingo Kato, Hiroto Murata, Hiroki Kiyohara, Kumiko Karasawa, Tatsuya Ohno, Hiroshi Tsuji, Takashi Nakano, Makio Shozu, for the Working Group of Gynecological Tumors Tags: COVER IMAGE Source Type: research

Issue Information
Cancer Medicine, Volume 9, Issue 4, Page 1277-1278, February 2020. (Source: Cancer Medicine)
Source: Cancer Medicine - February 13, 2020 Category: Cancer & Oncology Tags: ISSUE INFORMATION Source Type: research

Dynamic surveillance of tamoxifen ‐resistance in ER‐positive breast cancer by CAIX‐targeted ultrasound imaging
Targeted hypoxia ultrasonographic imaging presents an approach to dynamic surveillance of acquired antiestrogen therapeutic resistance in ER+ breast cancer. We established PLGA ‐PEG‐mAbCAIX nanobubbles and evaluated its conjunction with ultrasonographic imaging to accomplish these goals. The early tamoxifen resistance could be dynamically monitored by the noninvasive ultrasound NBs in patients, allowing for early intervention of tamoxifen resistance. AbstractTamoxifen ‐based hormone therapy is central for the treatment of estrogen receptor positive (ER+) breast cancer. However, the acquired tamoxifen resistance, typi...
Source: Cancer Medicine - February 13, 2020 Category: Cancer & Oncology Authors: Ying Li, Xiaoyu Chen, ZhiWei Zhou, Qing Li, Kenneth D. Westover, Meng Wang, Junjun Liu, Sheng Zhang, Jin Zhang, Bo Xu, Xi Wei Tags: ORIGINAL RESEARCH Source Type: research

Biological subtype predicts locoregional recurrence after postmastectomy radiotherapy in Chinese breast cancer patients
Our study demonstrated that biological subtype based on the classification standard from the St Gallen International Breast Cancer Conference (2013) Expert Panel serves as a reliable prognostic predictor for Chinese breast cancer patients receiving PMRT. Treatment with trastuzumab and endocrine therapy dramatically decreased the risk of LRR in HER2 ‐positive and hormonal receptor‐positive patients. AbstractAimTo investigate the impact of biological subtypes in locoregional recurrence in Chinese breast cancer patients receiving postmastectomy radiotherapy (PMRT).Methods and MaterialsAbout 583 patients who received postm...
Source: Cancer Medicine - February 13, 2020 Category: Cancer & Oncology Authors: Jiangfeng Wang, Jurui Luo, Kairui Jin, Xuanyi Wang, Zhaozhi Yang, Jinli Ma, Xin Mei, Xiaofang Wang, Zhirui Zhou, Xiaoli Yu, Xingxing Chen, Xiaomao Guo Tags: ORIGINAL RESEARCH Source Type: research

The prognostic value of standardized phase angle in adults with acute leukemia: A prospective study
Standardized phase angle (SPhA) is a tool used to estimate body composition and cell membrane integrity. Lower baseline SPhA was associated with increased incidence of 60 ‐day mortality in univariable (odds ratio [OR] = 5.25; 1.35, 20.44;P = .02) but not multivariable analysis (OR = 3.12; 0.67, 14.48;P = .15) adjusted for age, creatinine, and cytogenetics. Standardized phase angle is a rapid, noninvasive, and objective measure that may be used to inform risk stratification in adult acute leukemia patients. AbstractStandardized phase angle (SPhA) is a tool used to estimate body comp...
Source: Cancer Medicine - February 13, 2020 Category: Cancer & Oncology Authors: Samuel J. Yates, Susan Lyerly, Megan Manuel, Janet A. Tooze, Heidi D. Klepin, Bayard L. Powell, Sarah Dralle, Alok Uprety, Timothy S. Pardee Tags: ORIGINAL RESEARCH Source Type: research

Association between CD47 expression, clinical characteristics and prognosis in patients with advanced non ‐small cell lung cancer
ConclusionsCD47 overexpression is not a prognostic factor for PFS and OS in NSCLC patients. However, the presence of EGFR mutations and high expression of CD47 were associated with shortened PFS and OS. Coexpression of these markers represents a potential biomarker and characterizes a therapeutic niche for lung cancer. (Source: Cancer Medicine)
Source: Cancer Medicine - February 12, 2020 Category: Cancer & Oncology Authors: Oscar Arrieta, Alejandro Aviles ‐Salas, Mario Orozco‐Morales, Norma Hernández‐Pedro, Andrés F. Cardona, Luis Cabrera‐Miranda, Pedro Barrios‐Bernal, Giovanny Soca‐Chafre, Graciela Cruz‐Rico, María de Lourdes Peña‐Torres, Guada Tags: ORIGINAL RESEARCH Source Type: research

Individual and joint effects of metformin and statins on mortality among patients with high ‐risk prostate cancer
ConclusionsStatin use alone or in combination with metformin was associated with lower all ‐cause and PCa mortality among high‐risk patients, particularly in post‐diagnostic settings; further studies are warranted. (Source: Cancer Medicine)
Source: Cancer Medicine - February 11, 2020 Category: Cancer & Oncology Authors: Xiang ‐Lin Tan, Jian‐Yu E, Yong Lin, Timothy R. Rebbeck, Shou‐En Lu, Mingyi Shang, William K. Kelly, Anthony D'Amico, Mark N. Stein, Lanjing Zhang, Thomas L. Jang, Isaac Yi Kim, Kitaw Demissie, Anna Ferrari, Grace Lu‐Yao Tags: ORIGINAL RESEARCH Source Type: research

Fangjihuangqi Decoction inhibits MDA ‐MB‐231 cell invasion in vitro and decreases tumor growth and metastasis in triple‐negative breast cancer xenografts tumor zebrafish model
Fangjihuangqi Decoction could inhibit MDA ‐MB‐231 cell invasion in vitro and decrease tumor growth and metastasis in triple‐negative breast cancer xenografts tumor model zebrafish AbstractTriple ‐negative breast cancer (TNBC) is a basal‐like cancer which is considered to be more intrusive, have a poorer prognosis and chemoresistance. TNBC is characterized by the presence of epithelial to mesenchymal transition (EMT) that plays a major role in the progression of the cancer. In the presen t study, we first use a classic prescription of Chinese medicine Fangjihuangqi Decoction to treat TGFβ1‐induced MDA‐MB...
Source: Cancer Medicine - February 11, 2020 Category: Cancer & Oncology Authors: Yubo Guo, Yingyi Fan, Xiaohua Pei Tags: ORIGINAL RESEARCH Source Type: research

Exosomal Sonic Hedgehog derived from cancer ‐associated fibroblasts promotes proliferation and migration of esophageal squamous cell carcinoma
and this effect can be partly neutralized by the inhibitor of the Hedgehog signaling pathway. AbstractEsophageal squamous cell carcinoma (ESCC) is one of the most common and aggressive malignancies in China. Cancer ‐associated fibroblasts (CAFs) can actively communicate with and stimulate tumor cells, thereby contributing to the development and progression of tumors. Yet, whether CAFs‐derived exosomes have a role in the progression of ESCC is largely unknown. Here, we find that Sonic Hedgehog (SHH) is high ly expressed in CAFs lysis solution, conditioned medium of cultured CAFs (CAF‐CM) and CAFs‐derived exosomes, ...
Source: Cancer Medicine - February 7, 2020 Category: Cancer & Oncology Authors: Guiping Zhao, Hengcun Li, Qingdong Guo, Anni Zhou, Xingyu Wang, Peng Li, Shutian Zhang Tags: ORIGINAL RESEARCH Source Type: research

Genetic association analysis identifies a role for ANO5 in prostate cancer progression
Our genetic association study identified thatANO5 rs4622263 was associated with recurrence ‐free survival in patients with prostate cancer following radical prostatectomy. Additional analyses also provided evidence that rs4622263 affectsANO5 expression, which in turn is correlated with tumor aggressiveness and patient prognosis. AbstractAnoctamins were originally identified as a family of calcium ‐activated chloride channels, but recently their roles in the development of different types of malignancies were suggested. Here, we evaluated the associations between 211 common single‐nucleotide polymorphisms in 10 anocta...
Source: Cancer Medicine - February 7, 2020 Category: Cancer & Oncology Authors: Chia ‐Cheng Yu, Lih‐Chyang Chen, Chao‐Yuan Huang, Victor C. Lin, Te‐Ling Lu, Cheng‐Hsueh Lee, Shu‐Pin Huang, Bo‐Ying Bao Tags: ORIGINAL RESEARCH Source Type: research

PD ‐1 inhibitors for non‐small cell lung cancer patients with special issues: Real‐world evidence
ConclusionGiven the relatively low incidence of immune ‐related AEs and the comparability of clinical outcomes, ICIs can be treatment option of NSCLC patients with special issues. (Source: Cancer Medicine)
Source: Cancer Medicine - February 7, 2020 Category: Cancer & Oncology Authors: Seonggyu Byeon, Jang Ho Cho, Hyun Ae Jung, Jong ‐Mu Sun, Se‐Hoon Lee, Jin Seok Ahn, Keunchil Park, Myung‐Ju Ahn Tags: ORIGINAL RESEARCH Source Type: research

Upregulation of hsa_circ_0007874 suppresses the progression of ovarian cancer by regulating the miR ‐760/SOCS3 pathway
Downregulation of SOCS3 or overexpression of miR ‐760 restored the proliferation and migration ability of SKOV3 or A2780 cells overexpressing hsa_circ_0007874. Downregulation of SOCS3 restored the proliferation and migration in miR‐760 knockdown SKOV3 and A2780 cells. AbstractOvarian cancer (OVA) is a fatal and common malignancy in women worldwide. Circular RNAs (circRNAs) consist of a family of circular endogenous RNAs generated by selective splicing, and they are involved in many diseases. Previous studies reported that hsa_circ_0007874 is aberrantly expressed in cancer and functions in tumorigenesis. While the hsa_c...
Source: Cancer Medicine - February 6, 2020 Category: Cancer & Oncology Authors: Li Li, Poling Yu, Ping Zhang, Huanmei Wu, Qizhen Chen, Shuangdi Li, Yanqiu Wang Tags: ORIGINAL RESEARCH Source Type: research

Nomogram for predicting overall survival in stage II ‐III colorectal cancer
Four points are allocated for preoperative mean platelet volume, preoperative platelet distribution width, monocytes, and postoperative adjuvant chemotherapy. Nomogram for predicting 3 ‐ and 5‐year probabilities of colorectal cancer patients was established. Draw a vertical straight line from the variable value to the axis labeled “Points”. Then calculate all variables’ points. The total points on the bottom scales that correspond to the 3‐ and 5‐year survival were s howed apparently. AbstractPurposeThe overall survival (OS) of patients diagnosed with stage II ‐III colorectal cancer (CRC) can va...
Source: Cancer Medicine - February 6, 2020 Category: Cancer & Oncology Authors: Jungang Liu, Xiaoliang Huang, Wenkang Yang, Chan Li, Zhengtian Li, Chuqiao Zhang, Shaomei Chen, Guo Wu, Weishun Xie, Chunyin Wei, Chao Tian, Lingxu Huang, Franco Jeen, Xianwei Mo, Weizhong Tang Tags: ORIGINAL RESEARCH Source Type: research

Impact of somatic mutations on prognosis in resected non ‐small‐cell lung cancer: The Japan Molecular Epidemiology for lung cancer study
A prospective, multi ‐center, molecular epidemiology study of 876 surgically resected non‐small cell lung cancer cases, and the impact of somatic mutations (72 cancer‐associated genes) on recurrence‐free survival and overall survival (OS). A smaller number of co‐existing mutations, earlier stage, and younger a ge were associated with longer recurrence free survival and OS, while epidermal growth factor receptor mutations were significantly associated with improved OS. AbstractBackgroundTo report the follow up data and clinical outcomes of the JME study (UMIN 000008177), a prospective, multicenter, molecular epide...
Source: Cancer Medicine - February 6, 2020 Category: Cancer & Oncology Authors: Akihiro Tamiya, Yasuhiro Koh, Shun ‐ichi Isa, Akihito Kubo, Masahiko Ando, Hideo Saka, Naoki Yoshimoto, Sadanori Takeo, Hirofumi Adachi, Tsutomu Tagawa, Osamu Kawashima, Motohiro Yamashita, Kazuhiko Kataoka, Mitsuhiro Takenoyama, Yukiyasu Tags: ORIGINAL RESEARCH Source Type: research

Microsatellite instability and its associations with the clinicopathologic characteristics of diffuse large B ‐cell lymphoma
This study investigated MSI status in DLBCLs and analyzed the associations between MSI and clinicopathologic characteristics and clini cal outcomes. Ninety‐two cases of primary DLBCLs treated with R‐CHOP/CHOP chemotherapy between 2009 and 2017 were collected. MSI detection was performed by the Promega MSI Analysis System. The protein expression ofMLH1,MSH2,MSH6, andPMS2 was detected by immunohistochemistry. The associations of MSI ‐H and MSI‐L with progression‐free survival (PFS) and overall survival (OS) were assessed by COX models and Kaplan–Meier curves. The correlations of complete response (CR) after R...
Source: Cancer Medicine - February 6, 2020 Category: Cancer & Oncology Authors: Tian Tian, Jiwei Li, Tian Xue, Baohua Yu, Xiaoqiu Li, Xiaoyan Zhou Tags: ORIGINAL RESEARCH Source Type: research