Evodiamine potentiates cisplatin-induced cell death and overcomes cisplatin resistance in non-small-cell lung cancer by targeting SOX9- β-catenin axis
CONCLUSION: The combination of evodiamine and cisplatin may be a novel strategy for combating cisplatin resistance in NSCLC.PMID:38630183 | DOI:10.1007/s11033-024-09477-7 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 17, 2024 Category: Molecular Biology Authors: Munmun Panda Stuti Biswal Bijesh K Biswal Source Type: research

RIPK3 and RIPK1 gene expression in pterygium: unveiling molecular insights into pathogenesis
CONCLUSIONS: These findings suggest RIPK3 may play a protective role against pterygium recurrence through necroptosis.PMID:38630344 | DOI:10.1007/s11033-024-09368-x (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 17, 2024 Category: Molecular Biology Authors: Mahnaz Divandari Amin Javadifar Arezoo Baradaran Moghadam Ali Akbar Janatabadi Source Type: research

p-Smad3 differentially regulates the cytological behavior of osteoclasts before and after osteoblasts maturation
CONCLUSIONS: As pre-osteoblasts undergo maturation, p-Smad3 mediated a paracrine effect that transitions osteoclast cellular behaviors from inducing differentiation and stimulating bone formation to promoting apoptosis and coupling angiogenesis.PMID:38632128 | DOI:10.1007/s11033-024-09400-0 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 17, 2024 Category: Molecular Biology Authors: Jiapeng Ye Zhen Hua Jirimutu Xiao Yang Shao Shaoshuo Li Heng Yin Mao Wu Yi Rong Bowen Hong Yang Guo Yong Ma Jianwei Wang Source Type: research

Gene expression profiling of vitamin D metabolism enzymes in leukemia and lymphoma patients: molecular aspect interplay of VDR, CYP2R1, and CYP24A1
CONCLUSION: The study revealed a noteworthy difference in VDR protein levels between men and women. The highest mean CYP24A1 protein levels were observed in the age group > 60 years. This study found a significant, moderately positive correlation between VDR protein levels and CYP24A1 protein levels in the male and vitamin D sufficiency groups. In addition, a significant positive correlation was found between VDR mRNA levels and CYP2R1 mRNA levels, VDR mRNA levels and CYP2R1 mRNA levels, and CYP2R1 mRNA levels and CYP24A1 mRNA levels. However, the expression of these genes does not correlate with the protein levels of i...
Source: Molecular Biology Reports - April 17, 2024 Category: Molecular Biology Authors: Anggraini Iriani Andhika Rachman Marsya Kaila Fatina Rizka Kurnia Gemilang Andi Trisnandi Media Fitri Isma Nugraha Source Type: research

Evodiamine potentiates cisplatin-induced cell death and overcomes cisplatin resistance in non-small-cell lung cancer by targeting SOX9- β-catenin axis
CONCLUSION: The combination of evodiamine and cisplatin may be a novel strategy for combating cisplatin resistance in NSCLC.PMID:38630183 | DOI:10.1007/s11033-024-09477-7 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 17, 2024 Category: Molecular Biology Authors: Munmun Panda Stuti Biswal Bijesh K Biswal Source Type: research

RIPK3 and RIPK1 gene expression in pterygium: unveiling molecular insights into pathogenesis
CONCLUSIONS: These findings suggest RIPK3 may play a protective role against pterygium recurrence through necroptosis.PMID:38630344 | DOI:10.1007/s11033-024-09368-x (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 17, 2024 Category: Molecular Biology Authors: Mahnaz Divandari Amin Javadifar Arezoo Baradaran Moghadam Ali Akbar Janatabadi Source Type: research

Molecular characterization and evaluation of novel management options for Burkholderia glumae BG1, the causative agent of panicle blight of rice (Oryza sativa L.)
CONCLUSIONS: Overall, our study provides valuable insights into the potential and practical application of nano copper for the mitigation of bacterial panicle blight, offering promising prospects for commercial utilization in disease management.PMID:38625424 | DOI:10.1007/s11033-024-09498-2 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 16, 2024 Category: Molecular Biology Authors: Bhaskaran Sreenayana Kalyan Kumar Mondal Nivetha Mathiyalagan Kalaivanan Nagaranai Shanmugam Sanjeev Kumar Mrutyunjaya Shrinivas Reddy Chander Mani Source Type: research

A novel mutation in hERG gene associated with azithromycin-induced acquired long QT syndrome
CONCLUSIONS: These findings suggest that hERG gene mutations might be involved in the genetic susceptibility mechanism underlying acquired LQTS induced by azithromycin.PMID:38625436 | DOI:10.1007/s11033-024-09421-9 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 16, 2024 Category: Molecular Biology Authors: Yun-Jiu Cheng Yang Wu Hui-Qiang Wei Yi-Jian Liao Li-Ping Qu Yue-Han Pan Li-Juan Liu Wen-Tao Bi Source Type: research

Current knowledge about FLT3 gene mutations, exploring the isoforms, and protein importance in AML
Mol Biol Rep. 2024 Apr 16;51(1):521. doi: 10.1007/s11033-024-09452-2.ABSTRACTAcute myeloid leukaemia (AML) is a complex haematological malignancy characterised by diverse genetic alterations leading to abnormal proliferation of myeloid precursor cells. One of the most significant genetic alterations in AML involves mutations in the FLT3 gene, which plays a critical role in haematopoiesis and haematopoietic homeostasis. This review explores the current understanding of FLT3 gene mutations and isoforms and the importance of the FLT3 protein in AML. FLT3 mutations, including internal tandem duplications (FLT3-ITD) and point m...
Source: Molecular Biology Reports - April 16, 2024 Category: Molecular Biology Authors: Diana Mace čková Lenka Va ňková Monika Holubov á Pavel Jindra Robin Klieber Eli ška Jandová Pavel Pitule Source Type: research

Human umbilical cord mesenchymal stem cell-derived exosomes alleviate the severity of experimental autoimmune encephalomyelitis and enhance lag-3 expression on foxp3  + CD4 + T cells
CONCLUSIONS: These results suggest that hUMSCs-Exs could be a promising anti-inflammatory agent to regulate T-cell responses in EAE and other autoimmune diseases. However, further research is necessary to fully understand the underlying mechanisms and Lag-3's precise role in these conditions.PMID:38627337 | DOI:10.1007/s11033-024-09433-5 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 16, 2024 Category: Molecular Biology Authors: Adel Mohammadzadeh Masoud Lahouty Hamed Charkhian Arash Adamnejad Ghafour Sahand Moazzendizaji Jafar Rezaei Shahriar Alipour Vahid Shafiei Irannejad Mohammad Hassan Khadem Ansari Source Type: research

Next-generation probiotics: the upcoming biotherapeutics
Mol Biol Rep. 2024 Apr 15;51(1):505. doi: 10.1007/s11033-024-09398-5.ABSTRACTRecent and continuing advances in gut microbiome research have pointed out the role of the gut microbiota as an unexplored source of potentially beneficial probiotic microbes. Along the lines of these advances, both public awareness and acceptance of probiotics are increasing. That's why; academic and industrial research is dedicated to identifying and investigating new microbial strains for the development of next-generation probiotics (NGPs). At this time, there is a growing interest in NGPs as biotherapeutics that alter the gut microbiome and a...
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Omnia Momtaz Al-Fakhrany Engy Elekhnawy Source Type: research

Molecular typing and virulence characteristics of Escherichia coli strains isolated from hospital and community acquired urinary tract infections
CONCLUSION: Our findings indicate the presence of a wide variety of virulence factors in E. coli isolates and the possibility of spreading the same clones in different wards of the hospital.PMID:38622237 | DOI:10.1007/s11033-024-09485-7 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Zahra Naziri Abdollah Derakhshandeh Maryam Hajirajabi Fatemeh Abbasi Maryam Sadat Moezzi Abolfazl Shirmohamadi Sosfad Source Type: research

Cold atmospheric plasma attenuates skin cancer via ROS induced apoptosis
CONCLUSIONS: These evidences suggest the protective effect of CAP in CSCC, and CAP has the potential clinical application of CSCC.PMID:38622261 | DOI:10.1007/s11033-024-09486-6 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Changqing Liu Jingjing Zha Tao Sun Ling Kong Xinru Zhang Dong Wang Guohua Ni Source Type: research

Targeting phosphodiesterase 4 as a potential therapy for Parkinson's disease: a review
Mol Biol Rep. 2024 Apr 15;51(1):510. doi: 10.1007/s11033-024-09484-8.ABSTRACTPhosphodiesterases (PDEs) have become a promising therapeutic target for various disorders. PDEs are a vast and diversified family of enzymes that degrade cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), which have several biochemical and physiological functions. Phosphodiesterase 4 (PDE4) is the most abundant PDE in the central nervous system (CNS) and is extensively expressed in the mammalian brain, where it catalyzes the hydrolysis of intracellular cAMP. An alteration in the balance of PDE4 and cAMP results in th...
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Pooja Devi Nongthombam Reena Haobam Source Type: research

Resveratrol relieves HFD-induced insulin resistance in skeletal muscle tissue through antioxidant capacity enhancement and the Nrf2-Keap1 signaling pathway
CONCLUSIONS: These results suggest that resveratrol is effective in improving the antioxidant defense system of the skeletal muscle in HFD-fed mice, indicating its therapeutic potential to combat diseases associated with insulin resistance and oxidative stress.PMID:38622329 | DOI:10.1007/s11033-024-09434-4 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Maryam Shabani Hossein Hosseini Mohammad Hassan Tajik Reza Meshkani Asie Sadeghi Source Type: research