Identification of putative genetic variants in major depressive disorder patients in Pakistan
CONCLUSION: This present study identifies both common and rare variants in the genes associated with the pathogenesis of MDD in Pakistani patients. Genetic variations in BCR, RELN, and stress-associated PABPC1 suggest potential roles in the pathogenesis of MDD.PMID:35040003 | DOI:10.1007/s11033-021-07050-0 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 18, 2022 Category: Molecular Biology Authors: Sarah Rizwan Qazi Muhammad Irfan Zoobia Ramzan Muhammad Jahanzaib Maleeha Zaman Khan Mahrukh Nasir Muhammad Shakeel Ishtiaq Ahmad Khan Source Type: research

Effects of dihydroartemisinin, a metabolite of artemisinin, on colon cancer chemoprevention and adaptive immune regulation
CONCLUSIONS: As a metabolite of ART, DHA possessed stronger anti-CRC activities. The DHA significantly inhibited cell growth via cell cycle arrest, apoptosis induction and anti-inflammation actions. The adaptive immune regulation is a related mechanism of actions for the observed effects.PMID:35040004 | DOI:10.1007/s11033-021-07079-1 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 18, 2022 Category: Molecular Biology Authors: Chong-Zhi Wang Chunping Wan Yun Luo Chun-Feng Zhang Qi-Hui Zhang Lina Chen Zhi Liu Daniel H Wang Mallory Lager Cang-Hai Li Ting-Liang Jiang Lifei Hou Chun-Su Yuan Source Type: research

Seasonal expression of extracellular signal regulated kinases in the colon of wild ground squirrels (Spermophilus dauricus)
CONCLUSIONS: The expression of ERK1/2 and pERK1/2 was seasonal changes and had significant increases in the non-breeding season. This study revealed that ERK1/2 had potential roles in the colon to the adaptation of seasonal changes in wild ground squirrels.PMID:35040005 | DOI:10.1007/s11033-021-07042-0 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 18, 2022 Category: Molecular Biology Authors: Yue Song Xiaoying Yang Xueying Zhang Jueyu Zhu Yixin Chen Fuli Gao Haolin Zhang Yingying Han Qiang Weng Zhengrong Yuan Source Type: research

The effect of Myo-Inositol supplement on molecular regulation of folliculogenesis, steroidogenesis, and assisted reproductive technique outcomes in patients with polycystic ovarian syndrome
CONCLUSION: Our study provides new insight into the molecular mechanism underlying the positive effect of Myo-Inositol on intrinsic ovarian defects in PCOS, steroidogenesis, oocyte maturation, fertilization rate, and embryo quality.PMID:35040006 | DOI:10.1007/s11033-021-06833-9 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 18, 2022 Category: Molecular Biology Authors: Maryam Tabatabaie Sadegh Amiri Masoumeh Golestan Jahromi Azadeh Akbari Sene Zahra Zandieh Mehdi Mehdizadeh Fatemehsadat Amjadi Source Type: research

High-fat diet intake ameliorates the expression of hedgehog signaling pathway in adult rat liver
CONCLUSION: Excess fat deposits in liver due to chronic consumption of high-fat diet results in anomalous architecture and functioning. High-fat diet induced significant variations in Hh pathway genes expression; especially Shh, Ihh, Hhip, Ptch1, Smo, Gli1, Gli2, and Gli3 were upregulated. Infiltration of inflammatory cells ( ), widened sinusoidal spaces (▲), cellular necrosis, and micro vesicular steatotic hepatocytes (*) were shown in the liver. Significant collagen deposition in both HFD groups i.e. D-1 and D-2 confirmed liver fibrosis. Excessive intake of dietary fats impaired normal liver functioning and liver infla...
Source: Molecular Biology Reports - January 18, 2022 Category: Molecular Biology Authors: Rabia Mehmood Nadeem Sheikh Muhammad Babar Khawar Muddasir Hassan Abbasi Maryam Mukhtar Source Type: research

Low expression of LncRNA-CAF attributed to the high expression of HIF1A in esophageal squamous cell carcinoma and gastric cancer patients
CONCLUSION: The results suggested that FLJ22447 may have a regulatory function on the HIF1A expression. We identified the FLJ22447-interacted proteins and their molecular function in cancer pathogenesis. Further research emphasis is to realize the association of FLJ22447 with its protein partners in progression of cancer. These may provide an insight into the FLJ22447 activity that could introduce it as a potential value in tumor gene therapy.PMID:35040008 | DOI:10.1007/s11033-021-06882-0 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 18, 2022 Category: Molecular Biology Authors: Shabbou Bahramian Reza Sahebi Zahra Roohinejad Encieh Delshad Naeme Javid Abolfazl Amini Amirnader Emami Razavi Mohammad Shafiee Fatemeh T Shamsabadi Source Type: research

The effect of progesterone administration on the expression of metastasis tumor antigens (MTA1 and MTA3) in placentas of normal and dexamethasone-treated rats
Mol Biol Rep. 2022 Jan 17. doi: 10.1007/s11033-021-07005-5. Online ahead of print.ABSTRACTBACKGROUND: Dexamethasone (DEX) induces intrauterine growth restriction (IUGR) in pregnant rats. IUGR can occur due to apoptosis of trophoblasts, which is believed to be inhibited by progesterone (P4). A group of genes called MTAs play a role in proliferation and apoptosis. MTA1 upregulates trophoblasts proliferation and differentiation, while MTA3 downregulates proliferation and induces apoptosis. Hence, we hypothesized that during IUGR, placental MTA1 decreases and MTA3 increases and this is reversed by P4 treatment.METHODS: Pregnan...
Source: Molecular Biology Reports - January 17, 2022 Category: Molecular Biology Authors: M M Alawadhi F Al Shammari F Mulla Ali R Almatar A Al-Duwaikhi M D Al-Bader Source Type: research

Nanoliposomal formulation of pistachio hull extract: preparation, characterization and anti-cancer evaluation through Bax/Bcl2 modulation
CONCLUSION: The flow cytometry and real-time PCR results indicated the potential of this liposomal extract as an anti-cancer drug candidate for the treatment of liver cancer in the future, and the mitochondrial pathway involving the up-regulation of the Bax/Bcl-2 ratio can mediate its impact.PMID:35037194 | DOI:10.1007/s11033-021-07083-5 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 17, 2022 Category: Molecular Biology Authors: Hamidreza Harandi Soudeh Khanamani Falahati-Pour Mehdi Mahmoodi Sanaz Faramarz Haniyeh Maleki Fatemeh Bagheri Nasab Hamidreza Shiri Saba Fooladi Mohammad Hadi Nematollahi Source Type: research

Effects of different energy diets on DNA methylation and mRNA expression in follicle stimulating hormone receptor gene promoter region of Duolang sheep during estrus
In this study, polyembryo estrus Duolang sheep under different energy levels were selected as the experimental subjects. Dietary nutrient level reference (NY/T 816-2004), medium energy level was 10.88 MJ/day, high and low energy groups were increased and decreased by 15% on the basis of medium energy level, respectively 12.51 MJ/day, 9.25 MJ/day. Through RNA and DNA extraction, qPCR, bisulfitegenomicse-quencing PCR (BSP), sequence matching and other analysis of ovarian tissue of Duolang sheep. The difference of DNA methylation level and mRNA expression of FSHR gene during estrus in Duolang sheep fed with different energy d...
Source: Molecular Biology Reports - January 17, 2022 Category: Molecular Biology Authors: Bo Liu Hongjian Li Weikun Tao Fei Huang Xue Rui Jie Wang Peng Niu Di Fang Qinghua Gao Source Type: research

High glucose mediates apoptosis and osteogenesis of MSCs via downregulation of AKT-Sirt1-TWIST
CONCLUSION: Our data demonstrates that high glucose induces MSC apoptosis and enhances osteogenesis differentiation via downregulation of AKT-Sirt1-TWIST.PMID:35037196 | DOI:10.1007/s11033-021-07082-6 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 17, 2022 Category: Molecular Biology Authors: Wenxia Ren Miaomiao Chai Mingli Jiang Yan Zhou Wensong Tan Source Type: research

Mechanism of protection from insulin resistance by toll-like receptor 2 deficiency in high-fat diet fed mice: involvement in macrophage polarization
CONCLUSIONS: Our results reveal that TLR2 knockout-mediated macrophages M2 polarization is a crucial factor for preventing against diet-induced insulin resistance in mice. These findings deepen our knowledge about the mechanism underlying HFD-induced insulin resistance.PMID:35034283 | DOI:10.1007/s11033-021-07061-x (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 16, 2022 Category: Molecular Biology Authors: Yu Ma Xinyue Liu Yaliu Wu Wendong Wang Xiaotong Chang Source Type: research

Coenzyme Q10 reduces expression of apoptotic markers in adult rat nucleus accumbens dopaminergic neurons treated with methamphetamine
Mol Biol Rep. 2022 Jan 16. doi: 10.1007/s11033-021-07049-7. Online ahead of print.ABSTRACTBACKGROUND: Abuse of addictive drugs such as methamphetamine (METH) has become a global problem, leading to many social, economic, and health disturbances, including neurological and cognitive disorders. Neuronal damage is reported in chronic METH abusers. The neuroprotective role of CoQ10 has been shown in many studies. In the present study, we aimed to assess the pre and post-efficacy of CoQ10 on the dopaminergic neurons of the Nucleus Accumbens (de Miranda et al. in Food Res Int 121:641-647, 2019) in the male adult rats treated wit...
Source: Molecular Biology Reports - January 16, 2022 Category: Molecular Biology Authors: S B Jameie A Kazemian Z Sanadgol S Asadzadeh Bayqara Mana Sadat Jameie M Farhadi Source Type: research

Substance P modulates BMSCs migration for tissue repair through NK-1R/CXCR4/p-Akt signal activation
CONCLUSIONS: Our results suggested that SP promoted tissue repair through BMSCs migration via upregulation of CXCR4 and p-Akt. The expression of CXCR4 and p-Akt were regulated by NK-1R activation. These findings add more evidence in understanding the mechanisms of SP-induced BMSCs migration and highlight the potential for clinical implementation of SP in tissue repair.PMID:35034285 | DOI:10.1007/s11033-021-07044-y (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 16, 2022 Category: Molecular Biology Authors: Ran Tao Zhan Qu Ke Zhang Jie Chen Xinyu Wang Youming Deng Source Type: research

Probing the effects of sweet cherry (Prunus  avium L.) extract on 2D and 3D human skin models
CONCLUSION: The sweet cherry fruit extracts possesses significant activity in epidermis function without any potential of cytotoxicity or skin irritability, which makes it a rather promising active agent for skincare.PMID:35034286 | DOI:10.1007/s11033-021-07076-4 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 16, 2022 Category: Molecular Biology Authors: Sophia Letsiou Ioannis Ganopoulos Aliki Kapazoglou Aliki Xanthopoulou Eirini Sarrou Georgia Tanou Athanassios Molassiotis Source Type: research

The SAUR gene family in coffee: genome-wide identification and gene expression analysis during somatic embryogenesis
CONCLUSION: The identification of SAUR family on C. canephora genome followed by the analysis of gene expression profile across coffee somatic embryogenesis process on C. arabica represents a further additional step towards a better comprehension of molecular components acting on SE. Along with new research about this gene family such knowledge may support studies about clonal propagation methods via somatic embryogenesis to help the scientific community towards improvements into coffee crop.PMID:35034287 | DOI:10.1007/s11033-021-07011-7 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 16, 2022 Category: Molecular Biology Authors: Fabiana Couto Zanin Nat ália Chagas Freitas Renan Terassi Pinto Wesley Pires Flausino M áximo Leandro Eugenio Cardamone Diniz Luciano Vilela Paiva Source Type: research

Overexpression of a novel gene Aokap2 affects the growth and kojic acid production in Aspergillus oryzae
CONCLUSION: Taken together, these data suggest that a novel gene Aokap2 is involved in the growth and overexpression of Aokap2 increased kojic acid production through affecting the expression of laeA and kojA. The identification of Aokap2 provides a new target for genetic modification of the growth and the production of kojic acid in A. oryzae.PMID:35034288 | DOI:10.1007/s11033-021-07084-4 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 16, 2022 Category: Molecular Biology Authors: Yuzhen Li Huanxin Zhang Ziming Chen Junxia Fan Tianming Chen Yi Xiao Junyin Jie Bin Zeng Zhe Zhang Source Type: research

Mechanism of protection from insulin resistance by toll-like receptor 2 deficiency in high-fat diet fed mice: involvement in macrophage polarization
CONCLUSIONS: Our results reveal that TLR2 knockout-mediated macrophages M2 polarization is a crucial factor for preventing against diet-induced insulin resistance in mice. These findings deepen our knowledge about the mechanism underlying HFD-induced insulin resistance.PMID:35034283 | DOI:10.1007/s11033-021-07061-x (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 16, 2022 Category: Molecular Biology Authors: Yu Ma Xinyue Liu Yaliu Wu Wendong Wang Xiaotong Chang Source Type: research

Coenzyme Q10 reduces expression of apoptotic markers in adult rat nucleus accumbens dopaminergic neurons treated with methamphetamine
Mol Biol Rep. 2022 Jan 16. doi: 10.1007/s11033-021-07049-7. Online ahead of print.ABSTRACTBACKGROUND: Abuse of addictive drugs such as methamphetamine (METH) has become a global problem, leading to many social, economic, and health disturbances, including neurological and cognitive disorders. Neuronal damage is reported in chronic METH abusers. The neuroprotective role of CoQ10 has been shown in many studies. In the present study, we aimed to assess the pre and post-efficacy of CoQ10 on the dopaminergic neurons of the Nucleus Accumbens (de Miranda et al. in Food Res Int 121:641-647, 2019) in the male adult rats treated wit...
Source: Molecular Biology Reports - January 16, 2022 Category: Molecular Biology Authors: S B Jameie A Kazemian Z Sanadgol S Asadzadeh Bayqara Mana Sadat Jameie M Farhadi Source Type: research

Substance P modulates BMSCs migration for tissue repair through NK-1R/CXCR4/p-Akt signal activation
CONCLUSIONS: Our results suggested that SP promoted tissue repair through BMSCs migration via upregulation of CXCR4 and p-Akt. The expression of CXCR4 and p-Akt were regulated by NK-1R activation. These findings add more evidence in understanding the mechanisms of SP-induced BMSCs migration and highlight the potential for clinical implementation of SP in tissue repair.PMID:35034285 | DOI:10.1007/s11033-021-07044-y (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 16, 2022 Category: Molecular Biology Authors: Ran Tao Zhan Qu Ke Zhang Jie Chen Xinyu Wang Youming Deng Source Type: research

Probing the effects of sweet cherry (Prunus  avium L.) extract on 2D and 3D human skin models
CONCLUSION: The sweet cherry fruit extracts possesses significant activity in epidermis function without any potential of cytotoxicity or skin irritability, which makes it a rather promising active agent for skincare.PMID:35034286 | DOI:10.1007/s11033-021-07076-4 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 16, 2022 Category: Molecular Biology Authors: Sophia Letsiou Ioannis Ganopoulos Aliki Kapazoglou Aliki Xanthopoulou Eirini Sarrou Georgia Tanou Athanassios Molassiotis Source Type: research

The SAUR gene family in coffee: genome-wide identification and gene expression analysis during somatic embryogenesis
CONCLUSION: The identification of SAUR family on C. canephora genome followed by the analysis of gene expression profile across coffee somatic embryogenesis process on C. arabica represents a further additional step towards a better comprehension of molecular components acting on SE. Along with new research about this gene family such knowledge may support studies about clonal propagation methods via somatic embryogenesis to help the scientific community towards improvements into coffee crop.PMID:35034287 | DOI:10.1007/s11033-021-07011-7 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 16, 2022 Category: Molecular Biology Authors: Fabiana Couto Zanin Nat ália Chagas Freitas Renan Terassi Pinto Wesley Pires Flausino M áximo Leandro Eugenio Cardamone Diniz Luciano Vilela Paiva Source Type: research

Overexpression of a novel gene Aokap2 affects the growth and kojic acid production in Aspergillus oryzae
CONCLUSION: Taken together, these data suggest that a novel gene Aokap2 is involved in the growth and overexpression of Aokap2 increased kojic acid production through affecting the expression of laeA and kojA. The identification of Aokap2 provides a new target for genetic modification of the growth and the production of kojic acid in A. oryzae.PMID:35034288 | DOI:10.1007/s11033-021-07084-4 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 16, 2022 Category: Molecular Biology Authors: Yuzhen Li Huanxin Zhang Ziming Chen Junxia Fan Tianming Chen Yi Xiao Junyin Jie Bin Zeng Zhe Zhang Source Type: research

Increased expression of HMGB1 in the implantation phase endometrium is related to recurrent implantation failure
CONCLUSION: These findings strongly indicated that increased HMGB1 levels suppressed the epithelial cell adhesion capability, therefore contributing to impaired endometrial receptivity in patients with recurrent implantation failure, which can be used as a target for the recognition and treatment of recurrent implantation failure in clinical practice.PMID:35031923 | DOI:10.1007/s11033-021-06979-6 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 15, 2022 Category: Molecular Biology Authors: Mi Han Yi Cao Wenjie Zhou Mingjuan Zhou Xiaowei Zhou Dan Zhang Bufang Xu Aijun Zhang Source Type: research

First isolation and molecular characterization of pseudorabies virus detected in Turkey
CONCLUSIONS: This study confirms the possible presence of pseudorabies infection in the wildlife reservoirs in Turkey. Future studies may clarify the importance of the infection in Turkey region, where there is no prevalent pig production.PMID:35031924 | DOI:10.1007/s11033-021-06974-x (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 15, 2022 Category: Molecular Biology Authors: Gizem Aytogu Eda B Toker Ozkan Yavas Berfin Kadiroglu Ozer Ates Musa Ozgur Ozyigit Kadir Yesilbag Source Type: research

Kinases and therapeutics in pathogen mediated gastric cancer
CONCLUSION: Kinase amplifications could be used as diagnostic, prognostic, and predictive biomarkers in various cancer types. Hence targeting kinase and related signalling molecules could be considered as a potential approach to prevent cancer through these organisms. Here we summarize the brief information about the role of kinases, signalling and their therapeutics in GC concerning H. pylori, EBV and HCMV.PMID:35031925 | DOI:10.1007/s11033-021-07063-9 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 15, 2022 Category: Molecular Biology Authors: Charu Sonkar Nidhi Varshney Siva Koganti Hem Chandra Jha Source Type: research

Functions of lncRNA DUXAP8 in non-small cell lung cancer
Mol Biol Rep. 2022 Jan 15. doi: 10.1007/s11033-021-07066-6. Online ahead of print.ABSTRACTNon-small cell lung cancer (NSCLC) poses a serious threat to public health due to its significant morbidity and mortality rates. The processes of NSCLC formation and development are quite complex and involve numerous regulatory biomolecules. Long non-coding RNAs (lncRNAs) have attracted attention since they have been found to play critical roles in the tumorigenesis of various human malignancies. Recently, double homeobox A pseudogene 8 (DUXAP8) was identified as an oncogenic lncRNA that is overexpressed in different tumor types. In N...
Source: Molecular Biology Reports - January 15, 2022 Category: Molecular Biology Authors: Cui Wu Wu Song Zhongnan Wang Bingmei Wang Source Type: research

Spectrum of microRNAs and their target genes in cancer: intervention in diagnosis and therapy
Mol Biol Rep. 2022 Jan 15. doi: 10.1007/s11033-021-07040-2. Online ahead of print.ABSTRACTTill date, several groups have studied the mechanism of microRNA (miRNA) biogenesis, processing, stability, silencing, and their dysregulation in cancer. The miRNA coding genes recurrently go through abnormal amplification, deletion, transcription, and epigenetic regulation in cancer. Some miRNAs function as tumor promoters while few others are tumor suppressors based on the transcriptional regulation of target genes. A review of miRNAs and their target genes in a wide range of cancers is attempted in this article, which may help in t...
Source: Molecular Biology Reports - January 15, 2022 Category: Molecular Biology Authors: Alti Dayakar Kumar D Shanmukha Suresh K Kalangi Source Type: research

TRIP13 knockdown inhibits the proliferation, migration, invasion, and promotes apoptosis by suppressing PI3K/AKT signaling pathway in U2OS cells
CONCLUSIONS: TRIP13 knockdown reduced U2OS cell proliferation, migration, and invasion via a possible mechanism involving the PI3K/AKT signaling pathway.PMID:35032258 | DOI:10.1007/s11033-022-07133-6 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 15, 2022 Category: Molecular Biology Authors: De-Chen Yu Xiang-Yi Chen Hai-Yu Zhou De-Quan Yu Xiao-Lei Yu Yi-Cun Hu Rui-Hao Zhang Xiao-Bo Zhang Kun Zhang Mao-Qiang Lin Xi-Dan Gao Tao-Wen Guo Source Type: research

Increased expression of HMGB1 in the implantation phase endometrium is related to recurrent implantation failure
CONCLUSION: These findings strongly indicated that increased HMGB1 levels suppressed the epithelial cell adhesion capability, therefore contributing to impaired endometrial receptivity in patients with recurrent implantation failure, which can be used as a target for the recognition and treatment of recurrent implantation failure in clinical practice.PMID:35031923 | DOI:10.1007/s11033-021-06979-6 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 15, 2022 Category: Molecular Biology Authors: Mi Han Yi Cao Wenjie Zhou Mingjuan Zhou Xiaowei Zhou Dan Zhang Bufang Xu Aijun Zhang Source Type: research

First isolation and molecular characterization of pseudorabies virus detected in Turkey
CONCLUSIONS: This study confirms the possible presence of pseudorabies infection in the wildlife reservoirs in Turkey. Future studies may clarify the importance of the infection in Turkey region, where there is no prevalent pig production.PMID:35031924 | DOI:10.1007/s11033-021-06974-x (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 15, 2022 Category: Molecular Biology Authors: Gizem Aytogu Eda B Toker Ozkan Yavas Berfin Kadiroglu Ozer Ates Musa Ozgur Ozyigit Kadir Yesilbag Source Type: research

Kinases and therapeutics in pathogen mediated gastric cancer
CONCLUSION: Kinase amplifications could be used as diagnostic, prognostic, and predictive biomarkers in various cancer types. Hence targeting kinase and related signalling molecules could be considered as a potential approach to prevent cancer through these organisms. Here we summarize the brief information about the role of kinases, signalling and their therapeutics in GC concerning H. pylori, EBV and HCMV.PMID:35031925 | DOI:10.1007/s11033-021-07063-9 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 15, 2022 Category: Molecular Biology Authors: Charu Sonkar Nidhi Varshney Siva Koganti Hem Chandra Jha Source Type: research

Functions of lncRNA DUXAP8 in non-small cell lung cancer
Mol Biol Rep. 2022 Jan 15. doi: 10.1007/s11033-021-07066-6. Online ahead of print.ABSTRACTNon-small cell lung cancer (NSCLC) poses a serious threat to public health due to its significant morbidity and mortality rates. The processes of NSCLC formation and development are quite complex and involve numerous regulatory biomolecules. Long non-coding RNAs (lncRNAs) have attracted attention since they have been found to play critical roles in the tumorigenesis of various human malignancies. Recently, double homeobox A pseudogene 8 (DUXAP8) was identified as an oncogenic lncRNA that is overexpressed in different tumor types. In N...
Source: Molecular Biology Reports - January 15, 2022 Category: Molecular Biology Authors: Cui Wu Wu Song Zhongnan Wang Bingmei Wang Source Type: research

Spectrum of microRNAs and their target genes in cancer: intervention in diagnosis and therapy
Mol Biol Rep. 2022 Jan 15. doi: 10.1007/s11033-021-07040-2. Online ahead of print.ABSTRACTTill date, several groups have studied the mechanism of microRNA (miRNA) biogenesis, processing, stability, silencing, and their dysregulation in cancer. The miRNA coding genes recurrently go through abnormal amplification, deletion, transcription, and epigenetic regulation in cancer. Some miRNAs function as tumor promoters while few others are tumor suppressors based on the transcriptional regulation of target genes. A review of miRNAs and their target genes in a wide range of cancers is attempted in this article, which may help in t...
Source: Molecular Biology Reports - January 15, 2022 Category: Molecular Biology Authors: Alti Dayakar Kumar D Shanmukha Suresh K Kalangi Source Type: research

The role of indoleamine 2,3-dioxygenase in allergic disorders
Mol Biol Rep. 2022 Jan 14. doi: 10.1007/s11033-021-07067-5. Online ahead of print.ABSTRACTThe amino acid tryptophan (TRP) is critical for the expansion and survival of cells. During the past few years, the manipulation of tryptophan metabolism via indoleamine 2,3 dioxygenase (IDO) has been presented as a significant regulatory mechanism for tolerance stimulation and the regulation of immune responses. Currently, a considerable number of studies suggest that the role of IDO in T helper 2 (Th2) cell regulation may be different from that of T helper 1 (Th1) immune responses. IDO acts as an immunosuppressive tolerogenic enzyme...
Source: Molecular Biology Reports - January 14, 2022 Category: Molecular Biology Authors: Seyed-Alireza Esmaeili Jafar Hajavi Source Type: research

Naringenin enhances anti-proliferation effect of 1-ferrocenyl-3-(4-methylsulfonylphenyl) propen-1-one on two different cells via targeting calmodulin signaling pathway
CONCLUSIONS: It was shown that mechanism of proliferation inhibition in both cancer cells by these compounds is based on CaM and consequent PDE inhibition followed by intracellular cAMP level elevation and increased PKA activity in a dose-dependent manner.PMID:35028851 | DOI:10.1007/s11033-021-06923-8 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 14, 2022 Category: Molecular Biology Authors: Sadegh Rajabi Shokoofe Noori Mohammad Reza Ashrafi Mahsa Azami Movahed Shabnam Farzaneh Afshin Zarghi Source Type: research

Lower RNA expression of ALDH1A1 distinguishes the favorable risk group in acute myeloid leukemia
Mol Biol Rep. 2022 Jan 14. doi: 10.1007/s11033-021-07073-7. Online ahead of print.ABSTRACTThe expression and activity of enzymes that belong to the aldehyde dehydrogenases is a characteristic of both normal and malignant stem cells. ALDH1A1 is an enzyme critical in cancer stem cells. In acute myeloid leukemia (AML), ALDH1A1 protects leukemia-initiating cells from a number of antineoplastic agents, which include inhibitors of protein tyrosine kinases. Furthermore, ALDH1A1 proves vital for the establishment of human AML xenografts in mice. We review here important studies characterizing the role of ALDH1A1 in AML and its pot...
Source: Molecular Biology Reports - January 14, 2022 Category: Molecular Biology Authors: Garrett M Dancik Ioannis F Voutsas Spiros Vlahopoulos Source Type: research

Trichostatin A inhibits dendritic cell maturation through down-regulating NF- κ B (p65) pathway
CONCLUSIONS: TSA inhibits DC maturation through down-regulating NF-κB (p65) pathway.PMID:35028853 | DOI:10.1007/s11033-021-07065-7 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 14, 2022 Category: Molecular Biology Authors: Ying Yu Bing Liu Siyan Chen Jianxun Wang Feng Chen Tian Liu Nan Jiang Wensi Chen Shengbei Weng Xiaoxiao Cai Daoman Xiang Source Type: research

The role of  the gut microbiota and nutrition on spatial learning and spatial memory: a mini review based on animal studies
Mol Biol Rep. 2022 Jan 14. doi: 10.1007/s11033-021-07078-2. Online ahead of print.ABSTRACTThe gut-brain axis is believed to constitute a bidirectional communication mechanism that affects both mental and digestive processes. Recently, the role of the gut microbiota in cognitive performance has been the focus of much research. In this paper, we discuss the effects of gut microbiota and nutrition on spatial memory and learning. Studies have shown the influence of diet on cognitive capabilities such as spatial learning and memory. It has been reported that a high-fat diet can alter gut microbiota which subsequently leads to c...
Source: Molecular Biology Reports - January 14, 2022 Category: Molecular Biology Authors: Seyyed Mohammad Amin Alemohammad Seyed Mohammad Reza Noori Ehsan Samarbafzadeh Seyyed Mohammad Ali Noori Source Type: research

Mini review ATF4 and GRP78 as novel molecular targets in ER-Stress modulation for critical COVID-19 patients
Mol Biol Rep. 2022 Jan 14. doi: 10.1007/s11033-021-07071-9. Online ahead of print.ABSTRACTCoronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in more than 4.4 million deaths worldwide as of August 24, 2021. Viral infections such as SARS-CoV2 are associated with endoplasmic reticulum (ER) stress and also increased the level of reactive oxygen species. Activating transcription factor 4 (ATF4) is preferentially translated under integrated stress conditions and controls the genes involved in protein homeostasis, amino acid transport and metabolism, and ...
Source: Molecular Biology Reports - January 14, 2022 Category: Molecular Biology Authors: Mahtab Shahriari-Felordi Hani Keshavarz Alikhani Seyed-Mohammad Reza Hashemian Moustapha Hassan Massoud Vosough Source Type: research

Interaction of ONION2 ketoacyl CoA synthase with ketoacyl CoA reductase of rice
CONCLUSIONS: Our results suggest that ONI2 and KCR1 form an FAE complex that may play a role in biosynthesizing VLCFAs during shoot development.PMID:35028856 | DOI:10.1007/s11033-021-07060-y (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 14, 2022 Category: Molecular Biology Authors: Keita Kogure Akiko Watanabe Yukihiro Ito Source Type: research

High expression of HOXB3 predicts poor prognosis and correlates with tumor immunity in lung adenocarcinoma
CONCLUSION: Our study suggests that HOXB3 may play an oncogenic role in LUAD and correlate with tumor immunity.PMID:35028857 | DOI:10.1007/s11033-021-07064-8 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 14, 2022 Category: Molecular Biology Authors: Ming Yan Xiaojun Yin Luan Zhang Yuanbo Cui Xiwen Ma Source Type: research

Notch pathway inhibition mediated by arsenic trioxide depletes tumor initiating cells in small cell lung cancer
CONCLUSIONS: Our data demonstrate that As2O3 has a remarkable inhibitory effect on TICs of SCLC both in vitro and in vivo, and the mechanism might involve the down-regulation of Notch pathway.PMID:35028858 | DOI:10.1007/s11033-021-07046-w (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 14, 2022 Category: Molecular Biology Authors: Meng-Hang Yang Bing Li Ke-Jie Chang Source Type: research

The complete mitochondrial genome of an endemic cichlid Etroplus canarensis from Western Ghats, India (Perciformes: Cichlidae) and molecular phylogenetic analysis
CONCLUSION: The mitogenome sequence of E. canarensis may provide fundamental molecular data useful for further researches on genetic diversity, endemicity and the conservation of this endangered freshwater fish.PMID:35028859 | DOI:10.1007/s11033-022-07130-9 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 14, 2022 Category: Molecular Biology Authors: Joelin Joseph Sandeep Sreeedharan Sanil George Mano Mohan Antony Source Type: research

Midkine promotes breast cancer cell proliferation and migration by upregulating NR3C1 expression and activating the NF- κB pathway
CONCLUSIONS: Our findings highlight a novel mechanism by which MDK influences BC progression via regulation of the NF-κB-NR3C1 pathway.PMID:35028860 | DOI:10.1007/s11033-022-07116-7 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 14, 2022 Category: Molecular Biology Authors: Lin Zhang Li Song Yanyan Xu Yuting Xu Maojin Zheng Peng Zhang Qingling Wang Source Type: research

Mitogenome of Knodus borki (Cypriniformes: Characidae): genomic characterization and phylogenetic analysis
CONCLUSIONS: Our findings demonstrate that K. borki belongs to the family Characidae, due to consistency with the morphological identification. This study provides molecular information for further research on the phylogeny of the genus Knodus and for analyses of the taxonomic status of Characidae.PMID:35023005 | DOI:10.1007/s11033-021-06983-w (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 13, 2022 Category: Molecular Biology Authors: Cheng-He Sun Ya-Nan Zhang Xiao-Shu Zeng Da-Wei Liu Qi Huang Xiao-Li Zhang Qun Zhang Source Type: research

Relationship of matrix stiffness and cell morphology in regulation of osteogenesis and adipogenesis of BMSCs
CONCLUSIONS: Matrix stiffness failed to regulate BMSCs differentiation and YAP/TAZ activity without corresponding cell morphology. Cell spreading area could mediate effects of matrix stiffness on osteogenesis and adipogenesis of BMSCs.PMID:35023006 | DOI:10.1007/s11033-021-07075-5 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 13, 2022 Category: Molecular Biology Authors: Yutong Guo Yini Qiao Shuqi Quan Cai Yang Juan Li Source Type: research

Spectrum of HBB gene mutations among 696 β-thalassemia patients and carriers in Southern Vietnam
CONCLUSION: We provide here a comprehensive mutation spectrum of the HBB gene in Southern Vietnam, which is crucial for carrier screening and prenatal diagnosis in the future.PMID:35023007 | DOI:10.1007/s11033-021-07062-w (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 13, 2022 Category: Molecular Biology Authors: Phan Th ị Xinh Ho Quoc Chuong Nguyen Thi Thanh Ha Huynh Duong Bich Tram Cao Van Dong Le Vu Ha Thanh Nguyen Thi Hong Hoa Huynh Nghia Nguyen Tan Binh Phu Chi Dung Hoang Anh Vu Source Type: research

Applicability of inter-primer binding site iPBS- retrotransposon marker system for the assessment of genetic diversity and population structure of Peruvian rosewood (Aniba rosaeodora Ducke) germplasm
CONCLUSIONS: The results in this study such as higher genetic diversity indices, AMOVA (79%) within population and PIC value (0.343) showed the utility and reproducibility of iPBS-retrotransposons in this species successfully. The STRUCTURE algorithm separated the germplasms into six population groups according to their geographic locations. These results have valuable information for the conservation, management strategies and future breeding activities of rosewood.PMID:35023008 | DOI:10.1007/s11033-021-07056-8 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 13, 2022 Category: Molecular Biology Authors: Faheem Shehzad Baloch Stalin Juan Vasquez Guizado Muhammad Tanveer Altaf Ilker Y üce Yeter Çilesiz Mehmet Bedir Muhammad Azhar Nadeem Rustu Hatipoglu Juan Carlos Castro G ómez Source Type: research

Association of IL-6 promoter polymorphism hotspots (-  174G/C and - 572G/C) with cardiovascular disease risk factors
Mol Biol Rep. 2022 Jan 13. doi: 10.1007/s11033-021-07048-8. Online ahead of print.ABSTRACTBACKGROUND: Cardiovascular disease (CVD) is the leading cause of death globally, despite the recent advancements in clinical research. Early diagnosis of CVD and prevention of future complications are important for the management of CVD. In the present study, we determined the genotypic linkage of interleukin-6 (IL-6) promoters with the clinical, biochemical, and inflammatory markers of CVD in the Saudi population.MATERIALS AND METHODS: The study consisted of 89 patients (male and female) with CVD who were admitted at the King Abdulaz...
Source: Molecular Biology Reports - January 13, 2022 Category: Molecular Biology Authors: Shams Tabrez Nasimudeen R Jabir Torki A Zughaibi Mohd Suhail Source Type: research

Neuronal differentiation of mesenchymal stem cells by polyvinyl alcohol/Gelatin/crocin and beta-carotene
CONCLUSIONS: These results suggested that PVA/Gel/Cro 5% and βC could lead to hBMSCs differentiation to neural cells.PMID:35025028 | DOI:10.1007/s11033-022-07123-8 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 13, 2022 Category: Molecular Biology Authors: Niloofar Asghari Shiva Irani Mohamad Pezeshki-Moddaress Mojgan Zandi Marjan Mohamadali Source Type: research