A Novel Genes Signature Associated with the Progression of Polycystic Ovary Syndrome.
In this study, the comprehensive analysis of GSE8157 was downloaded. Overlapping genes of differentially expressed genes (DEGs) were identified, and enrichment analysis for these genes was performed. A modular network of differentially expressed genes was constructed by weighted gene co-expression network analyses (WGCNA), and a total of 322 differentially expressed genes in 5 stable modules were screened. The correlations of genes of the stable modules in BioGRID 3.4, STRING 10.5, HPRD9 databases were screened, and the interaction network of 104 DEGs was constructed. In addition, some genes and the key words were searched...
Source: Pathology Oncology Research - July 5, 2019 Category: Pathology Authors: He D, Liu L, Wang Y, Sheng M Tags: Pathol Oncol Res Source Type: research

AF1q Expression Associates with CD44 and STAT3 and Impairs Overall Survival in Adenoid Cystic Carcinoma of the Head and Neck.
Abstract Salivary gland malignancies of the head and neck form a heterogeneous group. Adenoid cystic carcinomas are an aggressive entity of salivary gland malignancies characterized by frequent distant metastases and poor response to radio- and chemotherapy. AF1Q is a MLL fusion partner, which can activate Wnt and STAT3 signaling. Recently, overexpression of AF1q has been identified as a poor prognosticator in patients of different malignancies. A total of 46 patients with adenoid cystic carcinoma were immunohistochemically evaluated for expression of AF1q and clinical outcome was analyzed in this context. Additio...
Source: Pathology Oncology Research - July 4, 2019 Category: Pathology Authors: Kadletz LC, Brkic FF, Jank BJ, Schneider S, Cede J, Seemann R, Gruber ES, Gurnhofer E, Heiduschka G, Kenner L Tags: Pathol Oncol Res Source Type: research

Peptidyl Arginine Deiminase, Type II (PADI2) Is Involved in Urothelial Bladder Cancer.
The objective of this study was to examine the role of PADI2 in urothelial bladder cancer which has not been evaluated previously. Analysis of mutation and genome amplification of bladder cancer within The Cancer Genome Atlas (TCGA) showed that PADI2 is both mutated and amplified in a cohort of bladder cancer patients, with the largest number of mutations detected in urothelial bladder cancer. Even though PADI2 expression was not significantly correlated to survival in bladder cancer patients, it was significantly overexpressed at the mRNA and protein levels, as revealed by TCGA data and immunohistochemistry analysis, resp...
Source: Pathology Oncology Research - July 2, 2019 Category: Pathology Authors: Gao BS, Rong CS, Xu HM, Sun T, Hou J, Xu Y Tags: Pathol Oncol Res Source Type: research

High Expression of Angiopoietin-like Protein 4 in Advanced Colorectal Cancer and its Association with Regulatory T Cells and M2 Macrophages.
Abstract Colorectal cancer (CRC) is one of the most aggressive tumours in the human digestive system. Most CRC patients have poor prognosis due to metastasis and recurrence. Angiopoietin-like 4 (ANGPTL4) is involved in tumour development. Regulatory T (Treg) cells and M2 macrophages promote tumour growth and metastasis. Herein, we explored the changes of ANGPTL4 expression in CRC patients at different stages and observed whether in situ tumour-Treg and -M2 macrophages are correlated with ANGPTL4 expression. Serum ANGPTL4 (sANGPTL4) levels of 70 CRC patients and 10 healthy controls were detected by ELISA. ANGPTL4, ...
Source: Pathology Oncology Research - July 1, 2019 Category: Pathology Authors: Zhou S, Tu J, Ding S, Lu G, Lin Z, Ding Y, Deng B, Zhang Y, Xiao W, Gong W Tags: Pathol Oncol Res Source Type: research

Immunological and Clinicopathological Significance of MFG-E8 Expression in Patients with Oral Squamous Cell Carcinoma.
The objective of this study is to elucidate the clinical relevance and significance of MFG-E8 in the tumor microenvironment (TME) of patients with oral squamous cell carcinoma (OSCC). We investigated MFG-E8 expression in 74 patients with OSCC by immunohistochemistry and evaluated the relationship between MFG-E8 expression and various clinicopathological factors including immune cell infiltration. MFG-E8 expression was detected in 34 of 74 (45.9%) patients with OSCC and a significant correlation was observed with levels of infiltrating T cells, macrophages, and immunosuppressive M2 macrophages. Furthermore, MFG-E8 expressio...
Source: Pathology Oncology Research - June 29, 2019 Category: Pathology Authors: Okamoto A, Sakakura K, Takahashi H, Motegi SI, Kaira K, Yokobori-Kuwabara Y, Ishikawa O, Chikamatsu K Tags: Pathol Oncol Res Source Type: research

Methods for Identifying Patients with Tropomyosin Receptor Kinase (TRK) Fusion Cancer.
Abstract NTRK gene fusions affecting the tropomyosin receptor kinase (TRK) protein family have been found to be oncogenic drivers in a broad range of cancers. Small molecule inhibitors targeting TRK activity, such as the recently Food and Drug Administration-approved agent larotrectinib (Vitrakvi®), have shown promising efficacy and safety data in the treatment of patients with TRK fusion cancers. NTRK gene fusions can be detected using several different approaches, including fluorescent in situ hybridization, reverse transcription polymerase chain reaction, immunohistochemistry, next-generation sequencing, an...
Source: Pathology Oncology Research - June 29, 2019 Category: Pathology Authors: Wong D, Yip S, Sorensen PH Tags: Pathol Oncol Res Source Type: research

Total Serum Cholesterol and Pancreatic Cancer Risk: What Is the Link?
PMID: 31254172 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - June 28, 2019 Category: Pathology Authors: Mormile R Tags: Pathol Oncol Res Source Type: research

The Association between Epidermal Growth Factor Receptor Single Nucleotide Polymorphisms and Radiochemotherapy Response in Cervical Cancer.
Abstract Emerging data reveal that epidermal growth factor receptor (EGFR) single nucleotide polymorphisms (SNPs) can act as efficacy indicators for tumor treatment. Here, the association between EGFR R497K (rs11543848) and -216G/T (rs712829) SNPs and radiochemotherapy response in cervical cancer was investigated. EGFR R497K and -216G/T genotypes were analyzed by polymerase chain reaction-ligation detection reaction in 196 cervical cancer patients receiving radiotherapy alone, or in combination with chemotherapy. Compared with the 497G/G genotype, the A/A genotype significantly increased sensitivity to radiochemot...
Source: Pathology Oncology Research - June 28, 2019 Category: Pathology Authors: Jin G, Fan XM, Li KX, Niu SH, Zhang QY Tags: Pathol Oncol Res Source Type: research

STIP1 Tissue Expression Is Associated with Survival in Chemotherapy-Treated Bladder Cancer Patients.
kely E, Reis H, Szarvas T Abstract To optimize treatment decisions in advanced bladder cancer (BC), we aimed to assess the therapy predictive value of STIP1 with regard to cisplatin therapy. Cisplatin-based chemotherapy represents the standard first-line systemic treatment of advanced bladder cancer. Since novel immunooncologic agents are already available for cisplatin-resistant or ineligible patients, biological markers are needed for the prediction of cisplatin resistance. STIP1 expression was analyzed in paraffin-embedded bladder cancer tissue samples of 98 patients who underwent adjuvant or salvage cisplatin-...
Source: Pathology Oncology Research - June 27, 2019 Category: Pathology Authors: Krafft U, Tschirdewahn S, Hess J, Harke NN, Hadaschik BA, Nyirády P, Szendröi A, Szücs M, Módos O, Olah C, Székely E, Reis H, Szarvas T Tags: Pathol Oncol Res Source Type: research

A Single Nucleotide Polymorphism in GAS5 lncRNA is Associated with Risk of Bladder Cancer in Iranian Population.
Abstract Down-regulation of the long non-coding RNA (lncRNA) growth arrest-specific 5 (GAS5) has a pathogenic role in bladder cancer. Moreover, genomic variants of this lncRNA have been associated with risk of diverse cancers. In the present project, we genotyped two putative functional SNPs (rs2067079 and rs6790) in 122 bladder cancer patients and 150 age- and sex-matched healthy subjects. The rs2067079 was associated risk of bladder cancer in recessive inheritance model (TT vs.CC + CT: OR (95% Confidence interval (CI)) = 2.67 (1.27-5.62), adjusted P value = 0.02). The T ...
Source: Pathology Oncology Research - June 27, 2019 Category: Pathology Authors: Rakhshan A, Esmaeili MH, Kahaei MS, Taheri M, Omrani MD, Noroozi R, Ghafouri-Fard S Tags: Pathol Oncol Res Source Type: research

Association between Genetic Polymorphisms in microRNA Machinery Genes and Risk of Papillary Thyroid Carcinoma.
In this study, we found that frequency of DICER1 rs3742330G allele was significantly higher in controls compared to PTC patients. In addition, the DICER1 rs3742330 polymorphism was associated with lower risk of PTC in dominant (AG + GG vs. AA, OR = 0.5, 95%CI = 0.3-0.9, P = 0.03) model. No association was found between DROSHA rs6877842 and XPO5 rs11077 polymorphisms and PTC neither in dominant nor in recessive and allelic models. The frequency of DROSHA rs6877842GC genotype was higher in PTC patients with smaller tumor size (
Source: Pathology Oncology Research - June 27, 2019 Category: Pathology Authors: Mohammadpour-Gharehbagh A, Heidari Z, Eskandari M, Aryan A, Salimi S Tags: Pathol Oncol Res Source Type: research

Absence of EGFR C797S Mutation in Tyrosine Kinase Inhibitor-Na ïve Non-Small Cell Lung Cancer Tissues.
Absence of EGFR C797S Mutation in Tyrosine Kinase Inhibitor-Naïve Non-Small Cell Lung Cancer Tissues. Pathol Oncol Res. 2019 Jun 26;: Authors: Oscorbin IP, Shadrina AS, Kozlov VV, Voitsitsky VE, Filipenko ML Abstract EGFR tyrosine-kinase inhibitors (TKIs) are used as targeted therapeutics for the treatment of advanced non-small cell lung cancer (NSCLC) with EGFR-activating mutations. EGFR C797S is common causes of acquired resistance to third-generation TKIs. There is wide-spread opinion that resistance-conferring mutation present even in a small proportion of cancer cells before the start of the...
Source: Pathology Oncology Research - June 26, 2019 Category: Pathology Authors: Oscorbin IP, Shadrina AS, Kozlov VV, Voitsitsky VE, Filipenko ML Tags: Pathol Oncol Res Source Type: research

The Relationship Between Tumor-Infiltrating Lymphocytes, PD-L1 Expression, Driver Mutations and Clinical Outcome Parameters in Non-Small Cell Lung Cancer Adenocarcinoma in Patients with a Limited to no Smoking History.
This study aimed to investigate these markers in lung adenocarcinoma (ADC) biopsies from patients with stage IIIB or IV ADC with little or no smoking history, to investigate their prognostic value and to correlate these results with the presence of driver mutations in the tumors. TIL were retrospectively evaluated on hematoxylin and eosin stained slides from 152 tumor samples. PD-1/PD-L1 expression was retrospectively evaluated with PD-1/PD-L1 immunohistochemistry (IHC) double staining on 74 tumor samples with sufficient residual tissue. PD-L1 expression was analysed on stromal cells of the tumor compartment, the tumor cel...
Source: Pathology Oncology Research - June 21, 2019 Category: Pathology Authors: Mignon S, Willard-Gallo K, Van den Eynden G, Salgado R, Decoster L, Marien KM, Vansteenkiste JF, Teugels E, De Grève J Tags: Pathol Oncol Res Source Type: research

Body Fat and Risk of Breast Cancer in Postmenopausal Women: What Is the Truth?
PMID: 31228074 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - June 21, 2019 Category: Pathology Authors: Mormile R Tags: Pathol Oncol Res Source Type: research

Immune Checkpoint Inhibitor Therapy in HIV-Positive Patients with Advanced-Stage Cancer: a Golden Card to Be Played?
PMID: 31222691 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - June 20, 2019 Category: Pathology Authors: Mormile R Tags: Pathol Oncol Res Source Type: research

Solid-pseudopapillary Neoplasms of the Pancreas is still an Enigma: a Clinicopathological Review.
Abstract The solid-pseudopapillary neoplasm of the pancreas is a rare but enigmatic entity occurring mainly in young women. Since the first description by V. Frantz in 1959 the terminology of this tumor has continuously changed but it has remained simply descriptive, because the exact histogenesis is still obscure. Although in majority of cases the survival is excellent, nevertheless, the expected prognosis is not exactly predictable. In this review the authors aim to summarize its clinico-pathological features, the expected biological behavior, the molecular alterations, the immune phenotype and discuss the putat...
Source: Pathology Oncology Research - June 17, 2019 Category: Pathology Authors: Zalatnai A, Kis-Orha V Tags: Pathol Oncol Res Source Type: research

Diabetes Mellitus Is Associated with Occult Cancer in Endometrial Hyperplasia.
Abstract In the management of women diagnosed with endometrial hyperplasia (EH), it is crucial to determine the risk of coexistent cancer. Diabetes mellitus has been recently suggested as a significant risk factor. However, results in this regard are conflicting. Our aim was to assess the association between diabetes mellitus and coexistent cancer in women diagnosed with endometrial hyperplasia. A systematic review and meta-analysis was performed by searching electronic databases from their inception to October 2018 for studies assessing the presence of coexistent cancer after a preoperative diagnosis of endo...
Source: Pathology Oncology Research - June 15, 2019 Category: Pathology Authors: Raffone A, Travaglino A, Saccone G, D'Alessandro P, Arduino B, Mascolo M, De Placido G, Insabato L, Zullo F Tags: Pathol Oncol Res Source Type: research

Comprehensive Data of P53 R282 Gene Mutation with Human Papillomaviruses (HPV)-Associated Oral Squamous Cell Carcinoma (OSCC).
Abstract Alterations of the P53 gene and human papillomavirus (HPV) infection are associated with development of oral squamous cell carcinoma (OSCC). We aimed to identify mutation of P53 exon 8 codon 282 in OSCC and correlate these with HPV infection as well as histopathological grade of OSCC. Samples of known HPV infection status were studied including oral lesion cells, formalin-fixed paraffin embedded (FFPE) tissues from OSCC and exfoliated oral cells of matched age-sex controls. P53 exon 8 mutation was detected using the polymerase chain reaction (PCR). Mutation of codon 282 was identified by allele-specific o...
Source: Pathology Oncology Research - June 13, 2019 Category: Pathology Authors: Ekalaksananan T, Wongjampa W, Phusingha P, Chuerduangphui J, Vatanasapt P, Promthet S, Patarapadungkit N, Pientong C Tags: Pathol Oncol Res Source Type: research

The Role of O6-methylguanine-DNA Methyltransferase Polymorphisms in Prostate Cancer Susceptibility: a Meta-Analysis.
Abstract To assess the associations between O6-methylguanine-DNA methyltransferase(MGMT) polymorphisms and prostate cancer risk. We retrieved PubMed, Cochrane Library and Embase electronic database to search for all eligible studies published from Jan 1, 1970 to Sep 31, 2017 to conduct a Meta-analysis. we identified 11 independent studies in 5 eligible reports, including 5143 cases and 8118 controls. The data suggested that rs12917 was associated with higher PCa risk under the contrast of TT vs CC and recessive model in overall population (TT vs CC: OR = 1.599, 95%CI: 1.007-2.539, P = 0...
Source: Pathology Oncology Research - June 13, 2019 Category: Pathology Authors: Zhang W, Liu M, Li Y, Song S, Li K, Ma Y Tags: Pathol Oncol Res Source Type: research

Inhibition of Metabolic Shift can Decrease Therapy Resistance in Human High-Grade Glioma Cells.
, Jeney A, Sebestyén A Abstract The high-grade brain malignancy, glioblastoma multiforme (GBM), is one of the most aggressive tumours in central nervous system. The developing resistance against recent therapies and the recurrence rate of GBMs are extremely high. In spite several new ongoing trials, GBM therapies could not significantly increase the survival rate of the patients as significantly. The presence of inter- and intra-tumoral heterogeneity of GBMs arise the problem to find both the pre-existing potential resistant clones and the cellular processes which promote the adaptation mechanisms such as m...
Source: Pathology Oncology Research - June 11, 2019 Category: Pathology Authors: Petővári G, Dankó T, Krencz I, Hujber Z, Rajnai H, Vetlényi E, Raffay R, Pápay J, Jeney A, Sebestyén A Tags: Pathol Oncol Res Source Type: research

p63 Expression and its Relation to Epithelial Cells Proliferation in Dentigerous Cyst, Odontogenic Keratocyst, and Ameloblastoma.
In conclusion, the present results indicated various expression and correlation of p63 with the proliferation of odontogenic epithelial cells in DC, OKC, and AB. This diversity could reflect a different role and pathways of ΔNp63 in odontogenic tumor than that in odontogenic cyst. These together will help in better understanding the pathogenesis and biological behavior of odontogenic cysts and tumors. PMID: 31187467 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - June 11, 2019 Category: Pathology Authors: Alsaegh MA, Altaie AM, Zhu S Tags: Pathol Oncol Res Source Type: research

Prognostic Value of Accumulative Expression of COX-2 and p53 in Small and Diffuse Large B Cell Lymphoma.
Abstract Cyclooxygenase-2 (COX-2) plays an important role in carcinogenesis, which catalyzes the conversion of arachidonic acid into prostaglandins. P53 is a tumor suppressor gene that contributes to apoptosis and cell cycle control. There is functional interaction between p53 and COX-2, which lead to abrogation of apoptosis and progression of malignancy. To assess the relationship between COX-2, p53 expression and the clinicopathololgic features in SLL and DLBCL. We immunohistochemically examined the expression of COX-2 and p53 in non-neoplastic lymphoid cells, lymph nodal low-grade (50 cases of SLL), intermediat...
Source: Pathology Oncology Research - June 11, 2019 Category: Pathology Authors: Zaky AH, Elsers D, Bakry R, Abdelwanis M, Nabih O, Hafez R, Rezk M Tags: Pathol Oncol Res Source Type: research

Evaluation of Alpha 1-Antitrypsin for the Early Diagnosis of Colorectal Cancer.
Abstract Previous proteomic studies have identified alpha 1-antitrypsin (A1AT) as a potential serum biomarker for colorectal cancer (CRC). In this case-control study, we evaluated plasma A1AT concentration and activity as a biomarker for the early diagnosis of colorectal cancer in a group of 113 sporadic CRC patients. We also analyzed A1AT gene promoter methylation, and genotypes in this group of CRC patients. The plasma A1AT and CEA concentrations were measured using the nephelometric and ELISA methods, respectively. A1AT activity was determined by Trypsin Inhibitor Capacity assay. The genomic DNA from blood samp...
Source: Pathology Oncology Research - June 10, 2019 Category: Pathology Authors: Jaberie H, Hosseini SV, Naghibalhossaini F Tags: Pathol Oncol Res Source Type: research

CUL1 Knockdown Attenuates the Adhesion, Invasion, and Migration of Triple-Negative Breast Cancer Cells via Inhibition of Epithelial-Mesenchymal Transition.
Abstract Cullin-1 (CUL1) is an important factor for tumor growth and a potential therapeutic target for breast cancer therapy, but the molecular mechanism in triple-negative breast cancer (TNBC) is unknown. In the present study, CUL1 shRNA was transfected into BT549 and MDA-MB-231 breast cancer cells. Cell morphology, adhesion, invasion, and migration assays were carried out in the CUL1 knockdown cells. Additionally, protein expression levels of epithelial-mesenchymal transition (EMT)-related factors, Akt phosphorylation at S473 (pAkt), glycogen synthase kinase-3β phosphorylation at ser9 (pGSK3β), cytopl...
Source: Pathology Oncology Research - June 7, 2019 Category: Pathology Authors: Ren ZQ, Yan WJ, Zhang XZ, Zhang PB, Zhang C, Chen SK Tags: Pathol Oncol Res Source Type: research

The Small Bowel Cancer Incidence Enigma.
Santos A, Assumpção C, Riggins G, Burbano R Abstract Although the small bowel is a vast organ with a highly proliferative epithelium, the incidence of small bowel cancers is surprisingly low. Many factors could be involved in this unexpected cancer incidence, including difficult access to the exploration of the small bowel mucosa, which might lead to missed diagnoses of non-obstructive and non-bleeding small tumours. Moreover, possible factors that influence the low incidence include more efficient machinery of DNA replication and DNA repair enzymes, peculiarities in microbiota components, competenc...
Source: Pathology Oncology Research - June 5, 2019 Category: Pathology Authors: Assumpção P, Khayat A, Araújo T, Barra W, Ishak G, Cruz A, Santos S, Santos Â, Demachki S, Assumpção P, Calcagno D, Santos N, Assumpção M, Moreira F, Santos A, Assumpção C, Riggins G, Burbano R Tags: Pathol Oncol Res Source Type: research

Tissue HE4 Expression Discriminates the Ovarian Serous Carcinoma but Not the Uterine Serous Carcinoma Patients. A New Adjunct to the Origin of the Tumor Site.
Abstract Both uterine serous carcinoma (USC) and ovarian serous carcinoma (OSC) are presented at advanced stage at the first admittion and dissseminated disease makes the anatomical site of the tumor origin imposible. CA125 and p53 are reliable markers that are useful for differentiating both uterine serous and ovarian serous carcinoma from their most common subtypes (endometrioid type carcinoma of ovary and uterus) but so far there is no histopathologic marker that differentiates USC from OSC. On the other hand, Trastuzumab (Herceptin) increases progression-free survival among USC patients, but not OSC patients a...
Source: Pathology Oncology Research - June 5, 2019 Category: Pathology Authors: Celik B, Bulut T, Yalcin AD Tags: Pathol Oncol Res Source Type: research

The Effect of Next-Generation TKI in Non-Small Cell Lung Cancer after Failure of First-Line Treatment: a Meta-Analysis.
Abstract Resistance develops against first-generation tyrosine kinase inhibitors (TKIs), which target the epidermal growth factor receptor (EGFR), after a while for non-small-cell lung cancer (NSCLC). Recently, researchers have developed specific inhibitors against them. Among those inhibitors, next-generation EGFR-TKIs have gained prominence due to the greater efficacy and more favorable tolerability. Today, the efficacy of next-generation EGFR-TKIs in patients with advanced NSCLC after failure on first-generation EGFR-TKIs still remains under investigation. The aim of this meta-analysis was to systematically ass...
Source: Pathology Oncology Research - May 31, 2019 Category: Pathology Authors: Zhang L, Ren HW, Wu QL, Wu YJ, Song X Tags: Pathol Oncol Res Source Type: research

Adaptation of Fatigue Affected Changes in Muscle EMG Frequency Characteristics for the Determination of Training Load in Physical Therapy for Cancer Patients.
Abstract Cancer patients often experience loss in body weight and also a decrease in muscle mass, which results in the reduction of physical activity and mobilization of the patient. To decelerate the loss of muscle mass, as part of the cancer treatment patients frequently undergo physical therapy and considering the physical capabilities of the patients, with moderate loads. Moreover, frequent studies also observed for cancer patients, together with the decrease in muscle mass a shift into fast-twitch muscle fibers from slow-twitch fibers. The aim of our study therefore was to determine how motor fibers behave un...
Source: Pathology Oncology Research - May 29, 2019 Category: Pathology Authors: Hegedus A, Trzaskoma L, Soldos P, Tuza K, Katona P, Greger Z, Zsarnoczky-Dulhazi F, Kopper B Tags: Pathol Oncol Res Source Type: research

Correction to: Phloretin Inhibits the Human Prostate Cancer Cells through the Generation of Reactive Oxygen Species.
Abstract AbstractThe original version of this article unfortunately contained an error in Figs. 1, 5 and 6. The asterisks and bars indicating statistical significance were missing in the figures. PMID: 31115862 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - May 21, 2019 Category: Pathology Authors: Kim U, Kim CY, Lee JM, Oh H, Ryu B, Kim J, Park JH Tags: Pathol Oncol Res Source Type: research

Effect of COPD on Inflammation, Lymphoid Functions and Progression-Free Survival during First-Line Chemotherapy in Advanced Non-small Cell Lung Cancer.
, Gálffy G Abstract Chronic obstructive pulmonary disease (COPD) is a common comorbidity of non-small cell lung cancer (NSCLC). COPD is characterized by systemic inflammation and lymphocyte dysfunction, mechanisms that are also known to accelerate progression of advanced (IIIB-IV) stage NSCLC. We aimed to find out whether COPD exerts an influence on tumor induced inflammatory and lymphoid responses and progression-free survival (PFS) after first-line treatment in advanced NSCLC. Patients suffering from NSCLC (n = 95), COPD (n = 54), NSCLC+COPD (n = 80) and healthy c...
Source: Pathology Oncology Research - May 14, 2019 Category: Pathology Authors: Szentkereszty M, Komlósi ZI, Szűcs G, Barna G, Tamási L, Losonczy G, Gálffy G Tags: Pathol Oncol Res Source Type: research

Predictive Value of ERCC1, ERCC2, and XRCC Expression for Patients with Locally Advanced or Metastatic Gastric Cancer Treated with Neoadjuvant mFOLFOX-4 Chemotherapy.
This study evaluated the correlation between the expression of three DNA repair genes, namely the excision repair cross-complementing group 1 (ERCC1), excision repair cross-complementing group 2 (ERCC2), and X-ray repair cross-complementing protein 1 (XRCC1) and the clinical outcome of patients with locally advanced or metastatic GC treated with mFOLFOX-4 neoadjuvant chemotherapy. Fifty-eight patients with histologically confirmed locally advanced or metastatic GC following neoadjuvant mFOLFOX-4 chemotherapy were enrolled between January 2009 and January 2018. We analyzed clinicopathological features and ERCC1, ERCC2, and ...
Source: Pathology Oncology Research - May 10, 2019 Category: Pathology Authors: Yeh YS, Chen YT, Tsai HL, Huang CW, Ma CJ, Su WC, Huang CM, Huang MY, Hu HM, Lu CY, Wang JY Tags: Pathol Oncol Res Source Type: research

Clinicopathologic Diagnostic and Prognostic Factors of Spindle Cell Carcinoma of Upper Airway.
This study aimed to review the clinical and pathological characteristics for diagnosis and prognosis. Retrospective cohort study. All patients with SpCC in upper respiratory tract treated for curative intent was included. All patients were reviewed in search of epithelial component and immunohistochemistry when not found. It was evaluated rate of recurrence and disease-free survival with univariate and multivariate analysis with Kaplan Meier and Cox Regression model adjusted to propensity score indexes (PSI) according to age, gender, site of tumor, stage, surgical treatment, status of margins of surgical resection, lymphat...
Source: Pathology Oncology Research - May 9, 2019 Category: Pathology Authors: de Araújo AB, Serrano TLI, Pedroso MCM, Mariano FV, Altemani A, Gripp FM, Crespo AN, Chone CT Tags: Pathol Oncol Res Source Type: research

Silencing UHRF1 Inhibits Cell Proliferation and Promotes Cell Apoptosis in Retinoblastoma Via the PI3K/Akt Signalling Pathway.
In conclusion, our study demonstrated that silencing UHRF1 could inhibit the proliferation of RB cells and promote apoptosis. The mechanism may be caused by the downregulation of the proportion of Bcl-2/Bax expression and the promotion of the expression of caspase-9 through the PI3K/Akt signalling pathway. PMID: 31044388 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - May 2, 2019 Category: Pathology Authors: Liu Y, Liang G, Zhou T, Liu Z Tags: Pathol Oncol Res Source Type: research

Distinct Angiogenic microRNA-mRNA Expression Profiles Among Subtypes of Lung Adenocarcinoma.
Abstract Adenocarcinoma (ADC) represents the most common histological type of non-small cell lung cancer (NSCLC), with a heterogeneous pattern of growth classified as lepidic, acinar, papillary, solid, and micropapillary. For ADC patients there are few available therapeutic options and a valuable therapeutic strategy is represented by angiogenesis inhibitors; however, new reliable biomarkers to identify patients with benefit from anti-angiogenic drugs are needed. We designed a panel of sixteen miRNAs together with six their mRNA targets involved in the angiogenesis pathway and expression analysis was performed by ...
Source: Pathology Oncology Research - May 2, 2019 Category: Pathology Authors: Boldrini L, Giordano M, Melfi F, Lucchi M, Fontanini G Tags: Pathol Oncol Res Source Type: research

All Benign and Malignant Apocrine Breast Lesions Over-Express Claudin 1 and 3 and Are Negative for Claudin 4.
This study was aimed at finding whether apocrine carcinoma, and other related apocrine breast lesions, have similar claudin profile. The immunohistochemical expression of claudin 1, 3 and 4 was studied in 11 cases of in situ and invasive apocrine breast carcinoma, 7 benign apocrine lesions and 45 consecutive morphologically non-apocrine triple negative breast carcinomas. All cases were also immunostained for Gross Cystic Disease Fluid Protein-15 (GCDFP-15), a marker for apocrine differentiation. Apocrine breast lesions maintained their expression pattern from benign through DCIS to invasive carcinoma; all showing strong ex...
Source: Pathology Oncology Research - May 1, 2019 Category: Pathology Authors: Shousha S, Anscombe O, McFarlane T Tags: Pathol Oncol Res Source Type: research

The Role of Interleukin-9 in Cancer.
Abstract Interluekin-9 (IL-9) is produced predominantly by helper T cells such as Th2 and Th9 cells. It normally functions through the activation of a JAK/STAT pathway and plays a critical role in immunity and the pathogenesis of cancer. In cancer, it yields different responses depending on the cancer cell line involved. This review is a summary of what is known about the involvement of IL-9 in various cancer cell lines as well as its role in immunity with a focus on allergic responses. PMID: 31016637 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - April 23, 2019 Category: Pathology Authors: Lee JE, Zhu Z, Bai Q, Brady TJ, Xiao H, Wakefield MR, Fang Y Tags: Pathol Oncol Res Source Type: research

Identifying Potential Prognostic Markers for Muscle-Invasive Bladder Urothelial Carcinoma by Weighted Gene Co-Expression Network Analysis.
Abstract Muscle-invasive bladder urothelial carcinoma (MIBC) is characterized as a genetic heterogeneous cancer with a high percentage of recurrence and worse prognosis. Identify the prognostic potentials of novel genes for muscle-invasive urothelial bladder cancer could at least provide important information for early detection and clinical treatment. Weighted gene co-expression network analysis (WGCNA) algorithm, a powerful systems biology approach, was utilized to extract co-expressed gene networks from mRNA expression dataset to construct transcriptional modules in MIBC samples, which was associated with demog...
Source: Pathology Oncology Research - April 22, 2019 Category: Pathology Authors: Feng Y, Jiang Y, Wen T, Meng F, Shu X Tags: Pathol Oncol Res Source Type: research

Comparison of CDH1 Gene Hypermethylation Status in Blood and Serum among Gastric Cancer Patients.
Abstract Hypermethylation is epigenetic alteration, well known for gene silencing. CHD1 gene is known as invasion and tumor suppressor gene, decreased expression due to hypermethylation could promote tumor cell invasion and metastasis. Present study designed to investigate the CDH1 gene promoter hypermethylation status by methylation specific polymerase chain reaction in 100 newly diagnosed gastric cancer patients. 53% of hypermethylation was observed in DNA extracted from blood in Gastric cancer patients while 66% was observed in serum based DNA. Significant differences in CDH1gene promoter hypermethylation was o...
Source: Pathology Oncology Research - April 15, 2019 Category: Pathology Authors: Li Z, Guo Z Tags: Pathol Oncol Res Source Type: research

Prognostic Significance of Serum PSA Level and Telomerase, VEGF and GLUT-1 Protein Expression for the Biochemical Recurrence in Prostate Cancer Patients after Radical Prostatectomy.
Abstract The aim of the study was to evaluate prognosis for biochemical recurrence (BR) by analysing the pathological and biological characteristics of prostate cancer (PCa) after radical prostatectomy (RP). There were 130 men with clinically localized PCa in whom pretreatment serum PSA level and Ki-67, prostate specific membrane antigen (PSMA), glucose transporter-1 (GLUT-1), vascular endothelial growth factor (VEGF), microvessel density (MVD) and human telomerase reverse transcriptase (hTERT) proteins expression, based on number of immunohistochemically positive cells (labelling index), were retrospectively stud...
Source: Pathology Oncology Research - April 15, 2019 Category: Pathology Authors: Gasinska A, Jaszczynski J, Rychlik U, Łuczynska E, Pogodzinski M, Palaczynski M Tags: Pathol Oncol Res Source Type: research

Identification of Pathogenic Genes and Transcription Factors in Osteosarcoma.
Abstract Osteosarcoma (OS) is an aggressive malignant tumor of the bones. Our study intended to identify and analyze potential pathogenic genes and upstream regulators for OS. We performed an integrated analysis to identify candidate pathogenic genes of OS by using three Gene Expression Omnibus (GEO) databases (GSE66673, GSE49003 and GSE37552). GO and KEGG enrichment analysis were utilized to predict the functional annotation and potential pathways of differentially expressed genes (DEGs). The OS-specific transcriptional regulatory network was established to study the crucial transcriptional factors (TFs) which ta...
Source: Pathology Oncology Research - April 13, 2019 Category: Pathology Authors: Yang C, Huang D, Ma C, Ren J, Fu L, Cheng C, Li B, Shi X Tags: Pathol Oncol Res Source Type: research

KIBRA Team Up with Partners to Promote Breast Cancer Metastasis.
Abstract Among women, breast cancer is the most frequently diagnosed cancer. Most of the breast cancers represent metastasis to distant organs at the time of diagnosis and accounts for the majority of deaths. Metastasis is characterized by many genetic aberrations including mutations, overexpression of oncogenes etc. KIBRA (KIdney/BRAin protein), a scaffolding protein is recently described as an important player in the process of invasion and metastasis. The Kidney/BRAin protein through its different domains interacts with various proteins to couple cytoskeleton arrangement, cell polarity and migration. N terminal...
Source: Pathology Oncology Research - April 11, 2019 Category: Pathology Authors: Singh G, Mishra S, Chander H Tags: Pathol Oncol Res Source Type: research

lncRNA SNHG16 Exerts Oncogenic Functions in Promoting Proliferation of Glioma Through Suppressing p21.
Abstract Glioma is a malignant brain tumor that accounts for 30% of all brain tumors and 80% of malignant brain tumors. This poor clinical outcome makes the study of molecular mechanisms in glioma as an urgent subject. However, the certain mechanism remains unclear. Long non-coding RNAs (lncRNAs) plays a key role in glioma development and progression. In the present study, we aimed to explore the potential mechanisms of lncRNA SNHG16 in glioma. The levels of lncRNA SNHG16 were qualified in both glioma tissues and cell lines using qRT-PCR assay. The ability of cell proliferation was tested via CCK-8 and colony form...
Source: Pathology Oncology Research - April 10, 2019 Category: Pathology Authors: Zhou XY, Liu H, Ding ZB, Xi HP, Wang GW Tags: Pathol Oncol Res Source Type: research

Differential Analysis of lncRNA, miRNA and mRNA Expression Profiles and the Prognostic Value of lncRNA in Esophageal Cancer.
Abstract Integrative central axis of lncRNA-miRNA-mRNA plays pivotal roles in tumor development and progression. However, the regulatory role of lncRNA-miRNA-mRNA in esophageal cancer remains elusive. TCGA database was utilized to investigate the differential expression of lncRNA, miRNA and mRNA in esophageal cancer (ESCA) and normal esophageal tissues, and GEO database was used to further validate the expression profile of key genes. Differential lncRNAs in TCGA database were submitted to Starbase, and lncRNAs related to overall survival were analyzed using Kaplan-Meier and log-rank test. We found 145 lncRNAs, 11...
Source: Pathology Oncology Research - April 10, 2019 Category: Pathology Authors: Liu H, Zhang Q, Lou Q, Zhang X, Cui Y, Wang P, Yang F, Wu F, Wang J, Fan T, Li S Tags: Pathol Oncol Res Source Type: research

C-X-C Chemokine Receptor Type 7 (CXCR-7) Expression in Invasive Ductal Carcinoma of Breast in Association with Clinicopathological Features.
Abstract C-X-C chemokine receptor type 7 (CXCR-7) is an atypical receptor for chemokines whose role in different stages of carcinogenesis has been evaluated in breast cancer cell lines and animal models. Moreover, it has been demonstrated to be a target of regulation by the tumor suppressor microRNA (miR)-100. In the present study, we assessed CXCR-7 expression in 60 breast cancer patients in association with clinicopathological and demographic data of patients. We also extracted the results of our previous work on miR-100 expression in the same cohort of patients to assess the correlation between miR-100 and CXCR...
Source: Pathology Oncology Research - April 7, 2019 Category: Pathology Authors: Shams R, Seifi-Alan M, Bandehpour M, Omrani MD, Ghafouri-Fard S Tags: Pathol Oncol Res Source Type: research

MicroRNA-182-5p Modulates Oral Squamous Cell Carcinoma Migration and Invasion Via Targeting MTSS1 Gene.
Abstract Oral squamous cell carcinoma (OSCC) characterized with invasive growth, local metastasis and later stage diagnosis was a common malignancy in head and neck region. The aim of this study was to explore the relationship between miR-182-5p and OSCC, which will contribute to find potential biomarker for OSCC metastasis. MiR-182-5p expression level was detected by the quantitative real-time PCR (qRT-PCR). Cell migration and invasion ability were examined by scratch and transwell assay. Loss-of function together with luciferase reporter assay were used to verify the miR-182-5p modulated OSCC cells migration and...
Source: Pathology Oncology Research - April 4, 2019 Category: Pathology Authors: Guo Y, Qiao X, Zhu L, Song R Tags: Pathol Oncol Res Source Type: research

Dynamic FDG-PET/CT in the Initial Staging of Primary Breast Cancer: Clinicopathological Correlations.
In conclusion, we confirmed a significant relationship between kinetic parameters measured by dynamic PET and the routinely assessed clinicopathological factors of breast cancer: high-grade, hormone-receptor negative tumors with high proliferation rate are characterized by higher cellular FDG-uptake and FDG-phosphorylation rate. Furthermore, we found that kinetic parameters based on the dynamic examinations are probably not influenced by stromal TIL infiltration. PMID: 30941738 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - April 3, 2019 Category: Pathology Authors: Kajáry K, Lengyel Z, Tőkés AM, Kulka J, Dank M, Tőkés T Tags: Pathol Oncol Res Source Type: research

The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma.
Abstract Advanced malignant pleural mesothelioma (MPM) has an extremely poor prognosis with limited chemotherapy options, therefore the identification of new therapeutic targets would aid in disease management. Arachidonic acid is metabolised by cyclooxygenase and lipoxygenase enzymes. The lipoxygenase isoenzymes 5-LOX and 12-LOX have been implicated in carcinogenesis. We aimed to examine 5-LOX and 12-LOX protein expression in a large retrospective series of mesothelioma samples. Further to this, the in vitro cytotoxic effects of lipoxygenase pathway inhibitors were investigated in mesothelioma cells. Archival sam...
Source: Pathology Oncology Research - April 2, 2019 Category: Pathology Authors: Oguh-Olayinka L, Agarwal V, Ranatunge D, Campbell A, Laufer S, Cawkwell L, Lind MJ Tags: Pathol Oncol Res Source Type: research

Phloretin Inhibits the Human Prostate Cancer Cells Through the Generation of Reactive Oxygen Species.
Abstract Phloretin is a flavonoid with known anticancer activities. However, we do not fully understand how phloretin mitigates prostate cancer on the molecular level. In the present study, we examined changes in proliferation, colony formation, and migration after phloretin treatment in human prostate cancer cells PC3 and DU145. We measured reactive oxygen species (ROS) and gene expression. Phloretin increased ROS and suppressed cell proliferation, migration, and colony formation in both cell lines. Additionally, phloretin treatment increased oxidative stress, as demonstrated through lower antioxidant enzymes (ca...
Source: Pathology Oncology Research - April 1, 2019 Category: Pathology Authors: Kim U, Kim CY, Lee JM, Oh H, Ryu B, Kim J, Park JH Tags: Pathol Oncol Res Source Type: research

Identification and Verification of Two Novel Differentially Expressed Proteins from Non-neoplastic Mucosa and Colorectal Carcinoma Via iTRAQ Combined with Liquid Chromatography-Mass Spectrometry.
Abstract Recurrence or metastasis of colorectal cancer (CRC) is common following surgery and/or adjuvant therapy, particularly in patients with an advanced stage of the cancer. Identifying key molecular markers of CRC is beneficial for early diagnosis and early treatment, which may eventually improve the prognosis of patients with CRC. Isobaric mass tags for relative and absolute quantification (iTRAQ) in combination with multidimensional liquid chromatography and tandem mass spectrometry (LC-MS/MS) were used to identify differentially expressed proteins between CRC tissues and paired adjacent normal mucosa. Among...
Source: Pathology Oncology Research - March 29, 2019 Category: Pathology Authors: Bai Y, Wang J, Gao Z, Dai E Tags: Pathol Oncol Res Source Type: research

Immune Checkpoint Inhibitors in Small Cell Lung Cancer: Is It Also a Matter of Helios- Cells?
PMID: 30927205 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - March 29, 2019 Category: Pathology Authors: Mormile R Tags: Pathol Oncol Res Source Type: research