Focal Adhesion Kinase (FAK) Overexpression and Phosphorylation in Oral Squamous Cell Carcinoma and their Clinicopathological Significance.
In this study, the immunohistochemically measured expression of FAK, phosphorylated FAK (FAKpY397) and p16 expressions and their associations with clinicopathological features and 5-year survival rates were examined in surgical samples from 70 patients with primary OSCC. FAK and FAKpY397 were expressed at high levels in 42 cases (60.0%) and 34 cases (48.6%), respectively, and 9 cases (12.9%) were positive for p16. FAK expression was significantly correlated with local recurrence, subsequent metastasis, and the mode of invasion. FAKpY397 expression was significantly correlated with both N classification and the mode of inva...
Source: Pathology Oncology Research - September 14, 2019 Category: Pathology Authors: Kato A, Kato K, Miyazawa H, Kobayashi H, Noguchi N, Kawashiri S Tags: Pathol Oncol Res Source Type: research

Positive Correlative over-Expression between eIF4E and Snail in Nasopharyngeal Carcinoma Promotes its Metastasis and Resistance to Cisplatin.
Abstract EIF4E is the rate-limiting factor in the mRNA translation of specific set of oncogenes. Snail is the core transcription factor of epithelial-mesenchymal transition (EMT), a key step of cancer metastasis. The connection between the two oncoproteins has not been well established in the human cancer tissues and in nasopharyngeal carcinoma (NPC). Here we showed that the positive correlative over-expression was seen between eIF4E and Snail in NPC tissues, and the expression was significantly higher in the metastatic NPC than in the un-metastatic NPC. In NPC cells, eIF4E knockdown significantly reduced Snail mR...
Source: Pathology Oncology Research - September 11, 2019 Category: Pathology Authors: Yao Y, Pang T, Cheng Y, Yong W, Kang H, Zhao Y, Wang S, Hu X Tags: Pathol Oncol Res Source Type: research

Monoclonal Caveolin 1 Expression in the Differential Diagnosis of Malignant Pleural Mesothelioma and Pulmonary Adenocarcinoma: Is it Useful?
In this study we aim to demonstrate the value of monoclonal Caveolin 1 expression in distinguishing between malignant pleural mesothelioma and pulmonary adenocarcinoma. Total of 129 cases, consisting of 68 cases of malignant pleural mesothelioma (51 epitheloid, 12 biphasic, and 5 sarcomatoid type) and 61 cases of pulmonary adenocarcinoma were examined and stained with monoclonal Caveolin-1. Caveolin 1 expression with a membranous and /or cytoplasmic pattern was detected only in 32.35% (n:22/68) of malignant pleural mesothelioma and 6.5% (n:4/61) of pulmonary adenocarcinoma cases. This finding suggests that the choice of po...
Source: Pathology Oncology Research - September 11, 2019 Category: Pathology Authors: Bozdag Z, Tutar E, Dizibuyuk OF, Bakir K Tags: Pathol Oncol Res Source Type: research

The Impact of Beta-Catenin and glutathione-S-transferase Gene Polymorphisms on the Treatment Results and Survival of Multiple Myeloma Patients.
In this study we analyzed if polymorphisms in the genes of β-catenin and glutathione-S-transferase have affected the clinical course, treatment response and progression-free survival (PFS) of MM patients. Ninety-seven MM patients were involved who were administered immunomodulatory drug (Imid) or alkylating agent-based therapy. β-catenin (CTNNB1, rs4135385 A > G, rs4533622 A > C) and glutathione-S-transferase (GSTP1 105, GSTP1 114) gene polymorphisms were analyzed by Light SNiP assays. The distribution of CTNNB1 (rs4135385) AA, AG and GG genotypes were 48.4%, 47.4% and 4,1%, resp...
Source: Pathology Oncology Research - September 10, 2019 Category: Pathology Authors: Pál I, Szilágyi B, Nagy B, Pál T, Hodosi K, Illés Á, Váróczy L Tags: Pathol Oncol Res Source Type: research

Loss of CHEK2 Predicts Progression in Stage pT1 Non-Muscle-Invasive Bladder Cancer (NMIBC).
Abstract Downregulation of checkpoint protein kinase 2 (CHEK2), which is involved in DNA repair, is associated with poorer outcome in various tumors. Little is known about the role of CHEK2 in urothelial carcinoma of the bladder (UCB). In the present study, we investigated the prognostic impact of CHEK2 protein expression in stage pT1 UCB. This retrospective, single-center analysis was carried out in a cohort of patients initially diagnosed with a pT1 UCB between 2007 and 2015. Immunohistochemical (IHC) staining of CHEK2 was performed. CHEK2 expression was correlated with recurrence-free survival (RFS), progressio...
Source: Pathology Oncology Research - September 10, 2019 Category: Pathology Authors: Spachmann PJ, Azzolina V, Weber F, Evert M, Eckstein M, Denzinger S, Burger M, Otto W, Breyer J Tags: Pathol Oncol Res Source Type: research

ALKBH5 Holds Prognostic Values and Inhibits the Metastasis of Colon Cancer.
Abstract N6-methyladenosine (m6A) demethylase ALKBH5 is best known for modulating transcript modification in plenty of human malignancies, but its role in the progression of colon cancer is not well understood. In the present study, we identified the tumor repressive role of ALKBH5 in colon cancer. ALKBH5 was downregulated in human colon cancer tissues, where its decreased expression significantly correlated with distant metastasis and American Joint Committee on Cancer (AJCC) stage. ALKBH5 was also an independent prognostic indicator of overall survival and disease-free survival in colon cancer patients. Furtherm...
Source: Pathology Oncology Research - September 10, 2019 Category: Pathology Authors: Yang P, Wang Q, Liu A, Zhu J, Feng J Tags: Pathol Oncol Res Source Type: research

Long-Non Coding RNA SNHG16 Supports Colon Cancer Cell Growth by Modulating miR-302a-3p/AKT Axis.
In conclusion, our study revealed the SNHG16/miR-302a-3p/AKT axis might play a crucial role in colon cancer cell proliferation, thus participating in the process of colon cancer development. PMID: 31502038 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - September 9, 2019 Category: Pathology Authors: Ke D, Wang Q, Ke S, Zou L, Wang Q Tags: Pathol Oncol Res Source Type: research

Potential Role of Magnesium in Cancer Initiation and Progression.
PMID: 31494817 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - September 7, 2019 Category: Pathology Authors: Gupta AA, Shekatkar M, Raj AT, Kheur S Tags: Pathol Oncol Res Source Type: research

Bioinformatics Analysis Suggests the Combined Expression of AURKB and KIF18B Being an Important Event in the Development of Clear Cell Renal Cell Carcinoma.
Abstract Clear cell renal cell carcinoma (ccRCC) is the most common type of renal cell carcinoma with high metastatic rate and high mortality rate, needing to find potential therapeutic targets and develop new therapy methods. The bioinformatics analysis was used in this study to find the targets. Firstly, the expression profile of ccRCC obtained from The Cancer Genome Atlas (TCGA) database and GSE53757 dataset were used to identify the significant up-regulated genes. IL20RB, AURKB and KIF18B with the top efficiency of capable of diagnosis ccRCC from para cancer tissue, were over-expressed in ccRCC samples, and ex...
Source: Pathology Oncology Research - September 5, 2019 Category: Pathology Authors: Liu Q, Zhang X, Tang H, Liu J, Fu C, Sun M, Zhao L, Wei M, Yu Z, Wang P Tags: Pathol Oncol Res Source Type: research

Expression and Clinical Significance of Translation Regulatory Long Non-Coding RNA 1 (TRERNA1) in Ependymomas.
Abstract Long noncoding RNAs (lncRNA) have emerged as vital molecules governing epithelial-to-mesenchymal transition (EMT) in cancers. Translation regulatory RNA 1 (TRERNA1) is one such lncRNA known to enhance the transcriptional activity of the EMT-transcription factor, Snail. We have previously demonstrated differential upregulation of EMT-transcription factors and cadherin switching across various clinico-pathologic-molecular subclasses of ependymomas (EPN). With an aim to analyze the correlation between the expression of TRERNA1 in EPNs, we performed gene expression analysis for TRERNA1 on 75 Grade II/III EPNs...
Source: Pathology Oncology Research - September 5, 2019 Category: Pathology Authors: Malgulwar PB, Nambirajan A, Singh M, Suri V, Sarkar C, Sharma MC Tags: Pathol Oncol Res Source Type: research

Expression of hTERT in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma - an Immunohistochemical Analysis.
Abstract Human telomerase reverse transcriptase enzyme, the catalytic subunit of telomerase are seen to be frequently reactivated in cancers including Oral squamous cell carcinoma (OSCC). Increased hTERT expression have been seen in potentially malignant conditions including Oral submucous fibrosis (OSMF). The aim of the study was to evaluate the expression levels in OSMF, OSCC in the background of OSMF and OSCC using immunohistochemistry and also to correlate hTERT expression with clinicopathologic parameters. A total of 50 histopathologically diagnosed cases of 20 OSMF, 20 OSCC wherein 5 were OSCC in the backgro...
Source: Pathology Oncology Research - September 5, 2019 Category: Pathology Authors: Raju K L, Haragannavar VC, Patil S, Rao RS, Nagaraj T, Augustine D, Venkatesiah SS, Nambiar S Tags: Pathol Oncol Res Source Type: research

External Quality Assurance of Current Technology for the Testing of Cancer-Associated Circulating Free DNA Variants.
This study therefore evaluated the performance of diagnostic laboratories currently performing cfDNA testing in China, Australia and New Zealand. A total of 89 laboratories participated in this EQA program. Reference testing material comprised of cfDNA manufactured to contain six different genotypes in four different genes (EGFR, KRAS, BRAF, NRAS). The predicted genotypic variant allelic frequencies ranged between 0.5% - 2.5%. Proficiency testing used a z-score on the laboratory consensus allelic frequency data to compare laboratory performance for the detection of the different genotypes. Allelic frequency genotyping data...
Source: Pathology Oncology Research - September 5, 2019 Category: Pathology Authors: Chai SY, Peng R, Zhang R, Zhou L, Pillay N, Tay KH, Badrick T, Li J, Horan MP Tags: Pathol Oncol Res Source Type: research

Dysregulation of miR-204-3p Driven by the Viability and Motility of Retinoblastoma via Wnt/ β-catenin Pathway In Vitro and In Vivo.
Dysregulation of miR-204-3p Driven by the Viability and Motility of Retinoblastoma via Wnt/β-catenin Pathway In Vitro and In Vivo. Pathol Oncol Res. 2019 Sep 03;: Authors: Sun QX, Wang RR, Liu N, Liu C Abstract Retinoblastoma (RB) is a malignant intraocular tumor that frequently occurs in infants and toddlers. Although the most of RB patients in the developed countries could survival from this cancer, the patients in undeveloped areas are still suffering. The human retinal pigment epithelial cell line ARPE-19 and human retinoblastoma (RB) cell lines HXO-RB44, Y79, and WERI-Rb1 were cultured. The ...
Source: Pathology Oncology Research - September 3, 2019 Category: Pathology Authors: Sun QX, Wang RR, Liu N, Liu C Tags: Pathol Oncol Res Source Type: research

Clear Cell Odontogenic Carcinoma: a Clinicopathological and Immunocytochemical Analysis.
We report 5 new cases of CCOC, with a mean age of 52.4 years. The clinical and histopathologic data of the disease obtained from earlier literature (95 cases) and the 5 new cases were analyzed. Data were extracted, including demographics, histopathologic findings, clinical presentation, primary treatment and outcomes. Immunohistochemical results revealed that the cancer is positive for AE1/AE3, EMA and CK19, negative for smooth muscle actin SMA, Vim and S-100. EWSR1 translocation was also observed in the new cases, which may help in the diagnosis of CCOC. Metastases of CCOC were rare, but the local recurrence rate of ...
Source: Pathology Oncology Research - September 3, 2019 Category: Pathology Authors: Liu L, Zhang JW, Zhu NS, Zhu Y, Guo B, Yang XH Tags: Pathol Oncol Res Source Type: research

The Time Between Chemoradiation and Surgery for Rectal Carcinoma Negatively Influences Mesorectal Excision Quality.
P, Buka D, Grepl J, Petera J Abstract Total mesorectal excision quality (TMEq) is a prognostic factor associated with local recurrence in rectal adenocarcinoma. Neoadjuvant chemoradiotherapy (NCRT) reduces the risk of tumor recurrence, but may compromise TMEq. The time between NCRT and surgery (TTS) and how it influences TMEq and tumor control were evaluated. In prospective registry, 236 patients after NCRT and TME were analyzed. NCRT involved radiotherapy with 45 Gy to the pelvis, plus tumor boost dose 5.4 Gy with concurrent 5-fluorouracil infusion. NCRT was followed by TME after 9 weeks on averag...
Source: Pathology Oncology Research - September 3, 2019 Category: Pathology Authors: Sirák I, Pohanková D, Ferko A, Hovorková E, Rozkoš T, Vošmik M, Hodek M, Paluska P, Buka D, Grepl J, Petera J Tags: Pathol Oncol Res Source Type: research

Serotonin and Dopamine Receptor Expression in Solid Tumours Including Rare Cancers.
In conclusion, 5-HTR1B, 5-HTR2B, DRD1, and DRD2 show mRNA overexpression in a broad spectrum of common and rare cancers. 5-HTR2B protein is frequently highly expressed in human cancers, especially on endothelial cells. These findings support further investigation of especially 5HTR2B as a potential treatment target. PMID: 31478179 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - September 2, 2019 Category: Pathology Authors: Peters MAM, Meijer C, Fehrmann RSN, Walenkamp AME, Kema IP, de Vries EGE, Hollema H, Oosting SF Tags: Pathol Oncol Res Source Type: research

Leiomyoma with Bizarre Nuclei: a Study of 108 Cases Focusing on Clinicopathological Features, Morphology, and Fumarate Hydratase Alterations.
Laco J, Krbal L, Tichá I, Dundr P Abstract Leiomyoma with bizarre nuclei (LBN) is an uncommon variant of uterine smooth muscle neoplasm. Involvement of fumarate hydratase (FH) has been suggested in the pathogenesis of a subset of LBN. The goal of our study is to assess the clinicopathological, morphological, immunohistochemical and molecular findings focusing on FH in LBNs (n = 108) and compare it with the findings in usual leiomyomas (UL; n = 50) and leiomyosarcomas (LMS; n = 42). Immunohistochemically, loss of FH expression was found in 67/108 of LBN, 1/50 of UL ...
Source: Pathology Oncology Research - August 31, 2019 Category: Pathology Authors: Gregová M, Hojný J, Němejcová K, Bártů M, Mára M, Boudová B, Laco J, Krbal L, Tichá I, Dundr P Tags: Pathol Oncol Res Source Type: research

Epithelial-Mesenchymal Transition Predicts Survival in Oral Squamous Cell Carcinoma.
Abstract Synergistic loss of E-cadherin and acquisition of vimentin are characteristic feature of epithelial-mesenchymal transition (EMT) which confers an invasive phenotype of epithelial cancer cells. The aim of the study was to evaluate the prognostic significance of E-cadherin and vimentin expression individually and in combination as a measure of epithelial-mesenchymal transition (EMT) in oral squamous cell carcinoma (OSCC). Expression of E-cadherin and vimentin through immunohistochemical analysis was examined in 200 patients with surgically resected OSCC. Combined E-cadherin and vimentin expression was evalu...
Source: Pathology Oncology Research - August 31, 2019 Category: Pathology Authors: Wangmo C, Charoen N, Jantharapattana K, Dechaphunkul A, Thongsuksai P Tags: Pathol Oncol Res Source Type: research

Association between MICA rs2596542 Polymorphism with the Risk of Hepatocellular Carcinoma in Chronic Hepatitis C Patients.
In this study we investigated the impact of rs2596542A/G single nucleotide polymorphism (SNP) in the major histocompatibility complex class I chain-related sequence A (MICA) gene on HCV-induced hepatocellular carcinoma (HCC) susceptibility in a Brazilian population. In total, 252 HCV-infected patients (98 with HCV-induced HCC and 154 non-malignant HCV-induced liver cirrhosis) were enrolled and 98 healthy control subjects (negative anti-HCV). The MICA rs2596542 SNP genotypes were determined by real-time PCR assay. No differences in MICA genotype frequencies between HCV-induced cirrhosis patients and controls were observed. ...
Source: Pathology Oncology Research - August 31, 2019 Category: Pathology Authors: Marangon CG, de Bitencorte JT, Michita RT, Lunge VR, Dos Santos DC, Álvares-da-Silva MR, Simon D Tags: Pathol Oncol Res Source Type: research

The Pan-Cancer Atlas: a New Chapter in Cancer Molecular Targeting Therapy.
PMID: 31468361 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - August 29, 2019 Category: Pathology Authors: Hu HL, Zeng DD, Zang JL, Chen Z Tags: Pathol Oncol Res Source Type: research

Prognostic and Clinicopathological Correlations of Cell Cycle Marker Expressions before and after the Primary Systemic Therapy of Breast Cancer.
ute;, Kulka J, Krenács T, Dank M Abstract We aimed to analyze the expression of cell-cycle regulation markers - minichromosome maintenance protein 2 (MCM2), Ki-67, Cyclin-A and phosphohistone-H3 (PHH3) - in pre-treatment core-biopsy samples of breast carcinomas in correlation with known predictive and prognostic factors. Totally 52 core biopsy samples obtained prior to neoadjuvant therapy were analyzed. Immunohistochemistry was performed to analyze the expression of MCM2, Ki-67, Cyclin A and PHH3, which were correlated with the following clinicopathological parameters: clinical TNM, tumor grad...
Source: Pathology Oncology Research - August 24, 2019 Category: Pathology Authors: Tőkés T, Tőkés AM, Szentmártoni G, Kiszner G, Mühl D, Molnár BÁ, Kulka J, Krenács T, Dank M Tags: Pathol Oncol Res Source Type: research

Identification of Differentially Expressed Proteins from Smokeless Tobacco Addicted Patients Suffering from Oral Squamous Cell Carcinoma.
Abstract Oral squamous cell carcinoma (OSCC) is the eight most common malignancy worldwide with an incidence rate of 40% in south-east Asia. Lack of effective diagnostic tools at early stage and disease recurrence despite extensive treatments are main reasons for high mortality and low survival rates. The aim of current study was to identify differentially expressed proteins to explore potential candidate biomarkers having diagnostic significance. We performed comparative proteomic analysis of paired protein samples (cancerous buccal mucosa and adjacent normal tissue) from OSCC patients using a combination of two ...
Source: Pathology Oncology Research - August 24, 2019 Category: Pathology Authors: Malik UU, Siddiqui IA, Ilyas A, Hashim Z, Staunton L, Kwasnik A, Pennington SR, Zarina S Tags: Pathol Oncol Res Source Type: research

Accuracy of One-Step Nucleic Acid Amplification in Detecting Lymph Node Metastases in Endometrial Cancer.
Abstract One-step nucleic acid amplification (OSNA) is used to intraoperatively detect sentinel lymph node metastases in breast cancer. OSNA has also been proposed in endometrial cancer, but evidence in this regard is unclear to define the diagnostic accuracy of OSNA in detecting lymph node metastases in endometrial cancer. A systematic review and meta-analysis was performed by searching 8 electronic databases from their inception to March 2019 for studies testing the diagnostic accuracy of OSNA in detecting sentinel lymph node metastasis in endometrial cancer. Pathologic ultrastaging was the reference standard. S...
Source: Pathology Oncology Research - August 23, 2019 Category: Pathology Authors: Raffone A, Travaglino A, Santoro A, Esposito I, Angelico G, Spadola S, Zannoni GF Tags: Pathol Oncol Res Source Type: research

Breaking the Curse: Opening Students' Eyes to Pathology and Oncology Research.
a MVL Abstract Research is a particularly underexplored professional activity for physicians, leaving many medical students compelled to pursue a clinical career. However, the XXI century requires that physicians innovate and perform research that fuels their practice; students should have early exposure to research to explore it as a career path. It should be encouraged in the undergraduate program by having students take part in case reports, short communication presentations, and research seminars. As part of an educational strategy, students worked with faculty members to deliver a gynecologic oncology patholo...
Source: Pathology Oncology Research - August 22, 2019 Category: Pathology Authors: Rojas IEE, de Los Ángeles Segura-Azuara N, Cabrera MVL Tags: Pathol Oncol Res Source Type: research

Comment on "The Significance of Long Non-coding RNA HULC in Predicting Prognosis and Metastasis of Cancers: a Meta-Analysis".
Comment on "The Significance of Long Non-coding RNA HULC in Predicting Prognosis and Metastasis of Cancers: a Meta-Analysis". Pathol Oncol Res. 2019 Aug 22;: Authors: Wang B, Lin T, Huang Y PMID: 31440904 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - August 22, 2019 Category: Pathology Authors: Wang B, Lin T, Huang Y Tags: Pathol Oncol Res Source Type: research

Successful Retreatment with Elotuzumab for Multiple Myeloma with Extramedullary Relapse while Being Treated with Lenalidomide and Dexamethasone.
PMID: 31440905 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - August 22, 2019 Category: Pathology Authors: Oka S, Ono K, Nohgawa M Tags: Pathol Oncol Res Source Type: research

Hsa_circ_0065149 is an Indicator for Early Gastric Cancer Screening and Prognosis Prediction.
Abstract Circular RNAs (circRNAs) are an endogenous RNAs with a covalently closed cyclic structure. They have emerged recently as key regulators in the development and progression of human cancers. However, the clinical values of most circRNAs in gastric cancer (GC) are unknown. Hsa_circ_0065149, one of the dysregulated circRNAs in gastric carcinogenesis detected by circRNA microarray, was chose as a targeted circRNA in this study. We firstly enlarged sample size and identified the level changes of hsa_circ_0065149 among four stages of gastric tumorigenesis from healthy gastric mucosa, gastritis, intestinal metapl...
Source: Pathology Oncology Research - August 20, 2019 Category: Pathology Authors: Shao Y, Tao X, Lu R, Zhang H, Ge J, Xiao B, Ye G, Guo J Tags: Pathol Oncol Res Source Type: research

Mcl-1 Inhibitor Induces Cells Death in BRAF-Mutant Amelanotic Melanoma Trough GSH Depletion, DNA Damage and Cell Cycle Changes.
Abstract Mcl-1 is a potent antiapoptotic protein and amplifies frequently in many human cancer. Currently, it is considered that the extensively expressed of Mcl-1 protein in melanoma cells is associated with rapid tumor progression, poor prognosis and low chemosensitivity. Therefore, the antiapoptotic protein Mcl-1 could be considered as a potential target for malignant melanoma treatment. The aim of this study was to assess the effect of MIM1 a specific low molecular Mcl-1 protein inhibitor and mixture of MIM1 and dacarbazine on the viability, cell cycle progression and apoptosis induction in amelanotic C32 mela...
Source: Pathology Oncology Research - August 20, 2019 Category: Pathology Authors: Respondek M, Beberok A, Rzepka Z, Rok J, Wrześniok D Tags: Pathol Oncol Res Source Type: research

Primary and Secondary Breast Lymphoma: Focus on Epidemiology and Imaging Features.
Abstract Aim of this study was to select all the cases of Primary (PBL) and Secondary (SBL) Breast Lymphoma from our breast unit since 01/01/2000, to obtain up-to-date data on the prevalence of this rare pathology and to analyze imaging features, with a special focus on CT. All pathological reports of breast biopsies performed from 01/01/2000 to 01/01/2019 were at first screened. Among them, we performed two different researches, looking for key words suggesting either a diagnosis of lymphoma or any other malignant disease. Using the Wiseman criteria, we identify PBL and SBL. All imaging features of PBL and SBL we...
Source: Pathology Oncology Research - August 20, 2019 Category: Pathology Authors: Picasso R, Tagliafico A, Calabrese M, Martinoli C, Pistoia F, Rossi A, Zaottini F, Derchi L Tags: Pathol Oncol Res Source Type: research

Nuclear Cytoplasmic Inclusions in Lung Adenocarcinoma: Relevance of Immunohistochemistry.
PMID: 31428992 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - August 19, 2019 Category: Pathology Authors: Adriana HL Tags: Pathol Oncol Res Source Type: research

Unraveling LGALS1 as a Potential Immune Checkpoint and a Predictor of the Response to Anti-PD1 Therapy in Clear Cell Renal Carcinoma.
Abstract Immunotherapy base on immune checkpoint inhibitor had obtained significant progress in extending the survival of clear cell renal carcinoma (ccRCC) patients. In order to further improve the efficiency of immunotherapy, novel immune checkpoint inhibitors needed to be developed. Differentially expressed genes (DEGs) between healthy kidney tissues and ccRCC tissues had been found from GSE68417 by GEO2R online analysis tool. Correlation analysis and Kaplan-Meier survival analyses were based on UALCAN database. Analyses of the outcome of anti-PD1 treatment had been found from GSE67501 dataset. At first, 9 gene...
Source: Pathology Oncology Research - August 19, 2019 Category: Pathology Authors: Li Y, Yang S, Yue H, Yuan D, Li L, Zhao J, Zhao L Tags: Pathol Oncol Res Source Type: research

Polymorphisms in XPC Gene and Risk of Uterine Leiomyoma in Reproductive Women.
This study indicated that genetic variations in XPC gene are associated with leiomyoma susceptibility in a reproductive women population. It warrants further confirmation in larger prospective studies with different populations. PMID: 31428994 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - August 19, 2019 Category: Pathology Authors: Liu ZQ, Lu MY, Liu B Tags: Pathol Oncol Res Source Type: research

Statin Therapy and Survival among Women with Ovarian Cancer: how much of it Is True?
PMID: 31420840 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - August 17, 2019 Category: Pathology Authors: Mormile R Tags: Pathol Oncol Res Source Type: research

Promoter Mutation Analysis of Long-Non-coding RNA RMRP Gene in Solid Tumors.
PMID: 31422524 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - August 17, 2019 Category: Pathology Authors: Son HJ, Mo HY, Choi EJ, Yoo NJ, Lee SH Tags: Pathol Oncol Res Source Type: research

Clinical Application of Long Non-Coding RNA-UCA1 as a Candidate Gene in Progression of Esophageal Cancer.
Abstract Esophageal cancer (EC) is known as one of the most prevalent gastrointestinal cancers, and results in the seventh highest number of cancer-relevant deaths. Long non-coding RNAs (lncRNAs) have substantial roles in several biological processes. LncRNA human urothelial carcinoma associated 1 (UCA1) is announced to be enhanced in multiple types of human cancers. This survey was carried out to identify the potential role of the lncRNA-UCA1 in the progression of EC. A case-control investigation was performed on 140 FFPE tissues of EC patients consisting of 70 cancerous tissues and 70 marginal tissues samples. T...
Source: Pathology Oncology Research - August 14, 2019 Category: Pathology Authors: Aalijahan H, Ghorbian S Tags: Pathol Oncol Res Source Type: research

Neuroendocrine Cancer of the Prostate.
Kullmann T Abstract Neuroendocrine cancer of the prostate is considered to be a rare entity with bad prognosis and limited therapeutic options. We performed a prospective analysis of the patients treated in our hospital for prostate cancer between 1st January 2015 and 31rd December 2018. Neuroendocrine phenomena were tested by immunohistochemistry and laboratory chemistry on the request of the clinicians in the cases when a positive diagnosis was suspected. Clinical tableaux of high suspicion of neuroendocrine cancer included radiological progression of a metastatic disease without PSA rise, relatively extended m...
Source: Pathology Oncology Research - August 14, 2019 Category: Pathology Authors: Kránitz N, Szepesváry Z, Kocsis K, Kullmann T Tags: Pathol Oncol Res Source Type: research

Expressions of Carbohydrate Response Element Binding Protein and Glucose Transporters in Liver Cancer and Clinical Significance.
Abstract Carbohydrate response element binding protein (ChREBP) is a glucose-sensing transcription factor that mediates the induction of glycolytic and lipogenic genes in response to glucose. We investigated the expression patterns of ChREBP and glucose transporters (GLUTs) in human hepatocellular carcinoma (HCC) and their association with HCC progression. ChREBP, GLUT2 and GLUT1 immunohistochemistry were performed on liver tissue array containing normal liver tissue, HCC adjacent tissue and cancer tissue of different HCC stages. The effect of HCC malignancy on protein expression was analyzed with one-way ANOVA. T...
Source: Pathology Oncology Research - August 12, 2019 Category: Pathology Authors: Lei Y, Hu Q, Gu J Tags: Pathol Oncol Res Source Type: research

Clinicopathological and Molecular Study of Peritoneal Carcinomatosis Associated with Non-Small Cell Lung Carcinoma.
In conclusion, PC might be the initial presentation of NSCLC. Molecular profiling of our cases did not find any effective targetable alteration, except from high PD-L1 expression. PMID: 31407221 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - August 12, 2019 Category: Pathology Authors: Nassereddine H, Sannier A, Brosseau S, Rodier JM, Khalil A, Msika S, Danel C, Couvelard A, Théou-Anton N, Cazes A Tags: Pathol Oncol Res Source Type: research

Role of Peritoneal Cytology in Patients with Early Stage Colorectal Cancer.
ez JS Abstract The main objective of this study was to investigate the incidence of free tumour cells in peritoneal lavage cytology performed using a standard method before and after the resection of the tumour, and to assess the usefulness of this technique in scheduled interventions on colorectal cancer patients. Peritoneal lavage cytology was performed on a homogeneous sample of 188 patients undergoing colorectal cancer curative resection before and after the resection of the tumour. The procedure was performed systematically in all cases. Malignant cells were detected in the peritoneal lavage cytology performe...
Source: Pathology Oncology Research - August 10, 2019 Category: Pathology Authors: Salamanca IMG, Jaime MTE, Penco JMM, Martínez JS Tags: Pathol Oncol Res Source Type: research

Lactate Dehydrogenase-to-Lymphocyte Ratio Represents a Powerful Prognostic Tool of Metastatic Renal Cell Carcinoma Patients Treated with Tyrosine Kinase Inhibitors.
Abstract Inflammation parameters were verified to predict clinical outcomes of metastatic renal cell carcinoma (mRCC) patients treated with tyrosine kinase inhibitors (TKIs). Here, we developed a novel marker, lactate dehydrogenase (tumor burden marker) to lymphocytes (inflammation marker) ratio (LLR), aimed to reveal the prognostic role of LLR for mRCC patients treated with TKIs. We collected clinical data of mRCC patients treated with TKIs. Receiver operating curve analysis was used to determine the optimal cut-off value. The c-index method was used to determine the best predictive marker for overall survival (O...
Source: Pathology Oncology Research - August 6, 2019 Category: Pathology Authors: Li T, Li H, Xie S, Tan Y, Xie ZP, Li WY, Ai F Tags: Pathol Oncol Res Source Type: research

Longitudinal Characteristics of Glioblastoma in Genome-Wide Studies.
Abstract Glioblastoma is one of the deadliest tumors with barely over one-year median survival despite intensive efforts in defining its molecular characteristics and searching for innovative treatment strategies. While major progress has been made in cataloging cross-sectional genomic, transcriptomic and epigenomic features of the tumor, and inferring its main molecular pathways and niches for potential targeted intervention, we still do not have sufficient knowledge concerning evolutionary patterns and dynamics of molecular changes or the treatment-induced effects affecting glioblastoma biology. In this review, ...
Source: Pathology Oncology Research - August 3, 2019 Category: Pathology Authors: Kraboth Z, Kalman B Tags: Pathol Oncol Res Source Type: research

Spinal Versus Intracranial Meningioma: Aberrant Expression of CD10 and Inhibin with Relation to Clinicopathological Features and Prognosis.
In conclusion, spinal meningiomas differ than intracranial ones in many clinicopathological and biological aspects. Among these differences is CD10 expression being more expressed in spinal meningiomas. However CD10 and inhibin are aberrantly expressed in a proportion of meningiomas, both have no relations to poor prognostic factors but more caution should be exerted during usage of these markers in diagnosis of hemangioblastoma and metastatic RCC. Further studies are suggested for exploring more biological differences between spinal and intracranial meningiomas. PMID: 31372897 [PubMed - as supplied by publisher] (Sou...
Source: Pathology Oncology Research - August 1, 2019 Category: Pathology Authors: Foda AAM, Rafi S, Ikram N, Alam MS, Ayesha S Tags: Pathol Oncol Res Source Type: research

Aspirin Use and Risk of Glioma: a Double Track for a Single Goal?
PMID: 31332695 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - July 22, 2019 Category: Pathology Authors: Mormile R Tags: Pathol Oncol Res Source Type: research

Upregulation of RUNX1 Suppresses Proliferation and Migration through Repressing VEGFA Expression in Hepatocellular Carcinoma.
Abstract Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, and occurs in people with chronic liver diseases. Current treatment methods include surgery, transplant, and chemotherapy. Our study demonstrates runt-related transcription factor 1 (RUNX1) as a novel molecule in the initiation and development of HCC, and the role of its interaction with vascular endothelial growth factor A (VEGFA) in HCC. We showed the suppressive role of RUNX1 in the proliferation and migration of hepatocytes. In addition, the repressor RUNX1 functioned as a transcription factor on the promoter of VEGFA to i...
Source: Pathology Oncology Research - July 9, 2019 Category: Pathology Authors: Liu C, Xu D, Xue B, Liu B, Li J, Huang J Tags: Pathol Oncol Res Source Type: research

Molecular Network-Based Identification of Circular RNA-Associated ceRNA Network in Papillary Thyroid Cancer.
This study aimed to describe the regulatory mechanisms in PTC. The expression profile of circRNA was download from the Gene Expression Omnibus (GEO) database. The mRNA and miRNA data of PTC was downloaded from The Cancer Genome Atlas (TCGA) database. The circRNA-miRNA-mRNA network by Cytoscape. The interactions between proteins were analyzed using the STRING database and hubgenes were identified using MCODE plugin. Then, we conducted a circRNA-miRNA-hubgenes regulatory module. Gene Ontology (GO) and Kyoto Encyclopedia of Gene and Genomes (KEGG) pathway analysis were conducted using R packages "Clusterprofile". We...
Source: Pathology Oncology Research - July 9, 2019 Category: Pathology Authors: Liu Q, Pan LZ, Hu M, Ma JY Tags: Pathol Oncol Res Source Type: research

A Novel Genes Signature Associated with the Progression of Polycystic Ovary Syndrome.
In this study, the comprehensive analysis of GSE8157 was downloaded. Overlapping genes of differentially expressed genes (DEGs) were identified, and enrichment analysis for these genes was performed. A modular network of differentially expressed genes was constructed by weighted gene co-expression network analyses (WGCNA), and a total of 322 differentially expressed genes in 5 stable modules were screened. The correlations of genes of the stable modules in BioGRID 3.4, STRING 10.5, HPRD9 databases were screened, and the interaction network of 104 DEGs was constructed. In addition, some genes and the key words were searched...
Source: Pathology Oncology Research - July 5, 2019 Category: Pathology Authors: He D, Liu L, Wang Y, Sheng M Tags: Pathol Oncol Res Source Type: research

AF1q Expression Associates with CD44 and STAT3 and Impairs Overall Survival in Adenoid Cystic Carcinoma of the Head and Neck.
Abstract Salivary gland malignancies of the head and neck form a heterogeneous group. Adenoid cystic carcinomas are an aggressive entity of salivary gland malignancies characterized by frequent distant metastases and poor response to radio- and chemotherapy. AF1Q is a MLL fusion partner, which can activate Wnt and STAT3 signaling. Recently, overexpression of AF1q has been identified as a poor prognosticator in patients of different malignancies. A total of 46 patients with adenoid cystic carcinoma were immunohistochemically evaluated for expression of AF1q and clinical outcome was analyzed in this context. Additio...
Source: Pathology Oncology Research - July 4, 2019 Category: Pathology Authors: Kadletz LC, Brkic FF, Jank BJ, Schneider S, Cede J, Seemann R, Gruber ES, Gurnhofer E, Heiduschka G, Kenner L Tags: Pathol Oncol Res Source Type: research

Peptidyl Arginine Deiminase, Type II (PADI2) Is Involved in Urothelial Bladder Cancer.
The objective of this study was to examine the role of PADI2 in urothelial bladder cancer which has not been evaluated previously. Analysis of mutation and genome amplification of bladder cancer within The Cancer Genome Atlas (TCGA) showed that PADI2 is both mutated and amplified in a cohort of bladder cancer patients, with the largest number of mutations detected in urothelial bladder cancer. Even though PADI2 expression was not significantly correlated to survival in bladder cancer patients, it was significantly overexpressed at the mRNA and protein levels, as revealed by TCGA data and immunohistochemistry analysis, resp...
Source: Pathology Oncology Research - July 2, 2019 Category: Pathology Authors: Gao BS, Rong CS, Xu HM, Sun T, Hou J, Xu Y Tags: Pathol Oncol Res Source Type: research

High Expression of Angiopoietin-like Protein 4 in Advanced Colorectal Cancer and its Association with Regulatory T Cells and M2 Macrophages.
Abstract Colorectal cancer (CRC) is one of the most aggressive tumours in the human digestive system. Most CRC patients have poor prognosis due to metastasis and recurrence. Angiopoietin-like 4 (ANGPTL4) is involved in tumour development. Regulatory T (Treg) cells and M2 macrophages promote tumour growth and metastasis. Herein, we explored the changes of ANGPTL4 expression in CRC patients at different stages and observed whether in situ tumour-Treg and -M2 macrophages are correlated with ANGPTL4 expression. Serum ANGPTL4 (sANGPTL4) levels of 70 CRC patients and 10 healthy controls were detected by ELISA. ANGPTL4, ...
Source: Pathology Oncology Research - July 1, 2019 Category: Pathology Authors: Zhou S, Tu J, Ding S, Lu G, Lin Z, Ding Y, Deng B, Zhang Y, Xiao W, Gong W Tags: Pathol Oncol Res Source Type: research

Immunological and Clinicopathological Significance of MFG-E8 Expression in Patients with Oral Squamous Cell Carcinoma.
The objective of this study is to elucidate the clinical relevance and significance of MFG-E8 in the tumor microenvironment (TME) of patients with oral squamous cell carcinoma (OSCC). We investigated MFG-E8 expression in 74 patients with OSCC by immunohistochemistry and evaluated the relationship between MFG-E8 expression and various clinicopathological factors including immune cell infiltration. MFG-E8 expression was detected in 34 of 74 (45.9%) patients with OSCC and a significant correlation was observed with levels of infiltrating T cells, macrophages, and immunosuppressive M2 macrophages. Furthermore, MFG-E8 expressio...
Source: Pathology Oncology Research - June 29, 2019 Category: Pathology Authors: Okamoto A, Sakakura K, Takahashi H, Motegi SI, Kaira K, Yokobori-Kuwabara Y, Ishikawa O, Chikamatsu K Tags: Pathol Oncol Res Source Type: research