Contribution of non-traditional lipid profiles to reduced glomerular filtration rate in H-type hypertension population of rural China.
Authors: Wang H, Li Z, Guo X, Chen Y, Chen S, Tian Y, Sun Y Abstract BACKGROUND: Despite current interest in the unfavourable impact of non-traditional lipid profiles on cardiovascular disease, information regarding its relations to reduced glomerular filtration rate (GFR) in H-type hypertension population has not been systemically elucidated. METHODS: Analyses were based upon a cross-sectional study of 3259 participants with H-type hypertension who underwent assessment of biochemical, anthropometric and blood pressure values. Reduced GFR was considered if meeting estimated GFR
Source: Annals of Medicine - August 14, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

Response to commentary by Pikus and Harbaugh on: A risk-benefit assessment strategy to exclude cervical artery dissection in spinal manual-therapy: a comprehensive review.
Authors: Chaibi A, Russell MB PMID: 31340677 [PubMed - as supplied by publisher] (Source: Annals of Medicine)
Source: Annals of Medicine - July 27, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

Clinical manifestations and outcomes of severe warfarin overanticoagulation: from the EWA study.
CONCLUSIONS: Bleeds are not the major determinant of the poor prognosis in severe overanticoagulation, as coincidental INR ≥9 findings also associate with high mortality. KEY MESSAGES Only a quarter of AF patients with INR ≥9 suffered a bleeding event and the clinical manifestation of INR ≥9 had a significant impact on patient outcome. The 30-day mortality rate in patients with INR ≥9 was high ranging from 9.2 to 32.7%. Several significant predictors of 30-day mortality after INR ≥9 were identified. PMID: 29156997 [PubMed - indexed for MEDLINE] (Source: Annals of Medicine)
Source: Annals of Medicine - July 24, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

Response to "Why all randomized controlled trials produce biased results".
Response to "Why all randomized controlled trials produce biased results". Ann Med. 2018 11;50(7):545-548 Authors: Althouse AD, Abebe KZ, Collins GS, Harrell FE PMID: 30122065 [PubMed - indexed for MEDLINE] (Source: Annals of Medicine)
Source: Annals of Medicine - July 24, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

Predictors of high hospital care and medication costs and cost trajectories in community-dwellers with Alzheimer's disease.
Conclusions: Although persons with AD are often collectively considered as expensive patient group, there is large temporal and inter-individual variation in belonging to the highest decile of hospitalization and/or medication costs. It would be important to assess whether hospitalization rate could be decreased by, e.g., comprehensive outpatient care with more efficient management of comorbidities. In addition, other interventions that could decrease hospitalization rate in persons with dementia should be studied further in this context. Key messages Persons with AD had large individual fluctuation in hospital care costs ...
Source: Annals of Medicine - July 21, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

Commentary on: A risk-benefit assessment strategy to exclude cervical artery dissection in spinal manual-therapy: a comprehensive review[1].
Authors: Pikus H, Harbaugh R PMID: 31282743 [PubMed - as supplied by publisher] (Source: Annals of Medicine)
Source: Annals of Medicine - July 11, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

The elevated CXCL5 levels in circulation are associated with lung function decline in COPD patients and cigarette smoking-induced mouse model of COPD.
Conclusions. Granulocyte-colony stimulating factor might coordinate with C-X-C motif chemokine 5 in the pathogenesis of neutrophilic inflammation in chronic obstructive pulmonary disease. Circulating C-X-C motif chemokine 5 might serve as a potential blood-based biomarker to add additional modest predictive value on the preliminary screening and diagnosis of chronic obstructive pulmonary disease. Key messages Circulating C-X-C motif chemokine 5 might serve as a potential blood-based biomarker to add additional modest predictive value on the preliminary screening and diagnosis of COPD. Granulocyte-colony stimulating factor ...
Source: Annals of Medicine - July 5, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

American Heart Association's Cardiovascular Health Metrics and Risk of Cardiovascular Disease Mortality Among a Middle-aged Male Scandinavian Population.
Authors: Isiozor NM, Kunutsor SK, Voutilainen A, Kurl S, Kauhanen J, Laukkanen JA Abstract Background: The burden of cardiovascular disease (CVD) prompted the American Heart Association to develop a cardiovascular health (CVH) metric as a measure to assess the cardiovascular status of the population. We aimed to assess the association between CVH scores and the risk of CVD mortality among a middle-aged Finnish population. Methods: We employed the prospective population-based Kuopio Ischemic Heart Disease cohort study comprising of middle-aged men (42 to 60 years). CVH scores were computed among 2,607 participants a...
Source: Annals of Medicine - July 4, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

A multidisciplinary consensus on dehydration: definitions, diagnostic methods and clinical implications.
Discussion: Dehydration poses risk to public health. Dehydration is under-recognized and poorly managed in hospital and community-based care. Further research is required to improve assessment and management of dehydration and the authors have made recommendations to focus academic endeavours. Key messages Dehydration assessment is a major clinical challenge due to a complex, varying pathophysiology, non-specific clinical presentations and the lack of international consensus on definition and diagnosis. Plasma osmolality represents a valuable, objective surrogate marker of hypertonic dehydration which is underutilized in c...
Source: Annals of Medicine - June 18, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

Joint 3rd International Congresses of CiiEM "Research & Innovation in Human and Health Sciences" and the "UNESCO Chair for Teaching & Research in Digital Anatomy Paris Descartes, 2018".
Joint 3rd International Congresses of CiiEM "Research & Innovation in Human and Health Sciences" and the "UNESCO Chair for Teaching & Research in Digital Anatomy Paris Descartes, 2018". Ann Med. 2019;51(sup1):i-vii Authors: PMID: 31135250 [PubMed - in process] (Source: Annals of Medicine)
Source: Annals of Medicine - May 29, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

Ten-year experience with transcatheter and surgical aortic valve replacement in Finland.
Authors: Mäkikallio T, Jalava MP, Husso A, Virtanen M, Laakso T, Ahvenvaara T, Tauriainen T, Maaranen P, Kinnunen EM, Dahlbacka S, Jaakkola J, Airaksinen J, Anttila V, Savontaus M, Laine M, Juvonen T, Valtola A, Raivio P, Eskola M, Niemelä M, Biancari F Abstract AIM: We investigated the outcomes of transcatheter (TAVR) and surgical aortic valve replacement (SAVR) in Finland during the last decade. METHODS: The nationwide FinnValve registry included data from 6463 patients who underwent TAVR or SAVR with a bioprosthesis for aortic stenosis from 2008 to 2017. RESULTS: The annual number of treated pa...
Source: Annals of Medicine - May 24, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

Non-invasive cardiac mapping for non-response in cardiac resynchronization therapy.
Authors: Strik M, Ploux S, Jankelson L, Bordachar P Abstract Cardiac resynchronization therapy (CRT) is an effective intervention in selected patients with moderate to severe heart failure with reduced ejection fraction and abnormal left ventricular activation time. The non-response rate of approximately 30% has remained nearly unchanged since this therapy was introduced 25 years ago. While intracardiac mapping is widely used for diagnosis and guidance of therapy in patients with tachyarrhythmia, its application in characterization of the electrical substrate to elucidate the mechanisms involved in CRT response rem...
Source: Annals of Medicine - May 18, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

Plasma Klotho concentrations predict functional outcome at three months after acute ischemic stroke patients.
Authors: Lee JB, Woo HG, Chang Y, Jin YM, Jo I, Kim J, Song TJ Abstract BACKGROUND: The Klotho protects the cardiovascular system by protecting against cell apoptosis, inhibiting the production of reactive oxygen species, and modulating inflammation. We aimed to investigate relationship of plasma Klotho concentrations with functional outcome at 3 months after acute cerebral infarction. METHODS: We prospectively enrolled 262 first-ever acute cerebral infarction patients from whom a blood sample was acquired within 24 hours of admission. An enzyme-linked immunosorbent assay was used for evaluating plasma K...
Source: Annals of Medicine - May 11, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

Massive transfusion in upper gastrointestinal bleeding: a new scoring system.
Authors: Chen YC, Chuang CJ, Hsiao KY, Lin LC, Hung MS, Chen HW, Lee SC Abstract BACKGROUND: Massive transfusion in patients with upper gastrointestinal bleeding (UGIB) not investigated. We developed a new scoring system to predict massive transfusion and to enhance care and early resource mobilization. METHODS: Massive transfusion was defined as transfusion with ≥10 units of red blood cells within the first 24 hours. Data were extracted from a 10-year, six-hospital database. Logistic regression was applied to derive a risk score for massive transfusion using data from 2006 to 2010, in 24,736 patients...
Source: Annals of Medicine - May 6, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

Incidence and prognosis of heart failure in persons with type 2 diabetes compared with individuals without diabetes - a nation-wide study from Finland in 1996-2012.
CONCLUSIONS: Individuals aged
Source: Annals of Medicine - May 6, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

Variability in the leptin receptor gene and other risk factors for post-transplant diabetes mellitus in renal transplant recipients.
Authors: Mota-Zamorano S, Luna E, Garcia-Pino G, González LM, Gervasini G Abstract AIM: Post-transplant diabetes mellitus (PTDM) is one of the main complications after kidney transplantation. It is known that leptin plays an important role in glucose metabolism and mutations in the leptin receptor gene (LEPR) are responsible for different complications in renal transplant recipients. We aimed to analyse the association of polymorphisms in LEPR with the development of PTDM in these patients. METHODS: A total of 315 renal transplant recipients were genotyped for the Lys109Arg, Gln223Arg and Lys656Asn polym...
Source: Annals of Medicine - May 4, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

Glycaemic efficacy and safety of linagliptin for the management of non-cardiac surgery patients with type 2 diabetes in a real-world setting: Lina-Surg Study.
Authors: Pérez-Belmonte LM, Osuna-Sánchez J, Millán-Gómez M, López-Carmona MD, Gómez-Doblas JJ, Cobos-Palacios L, Sanz-Cánovas J, Barbancho MA, Lara JP, Jiménez-Navarro M, Bernal-López MR, Gómez-Huelgas R Abstract INTRODUCTION: The use of dipeptidyl peptidase-4 inhibitors in hospitalized patients is an area of active research. We aimed to compare the efficacy and safety of the basal-bolus insulin regimen versus linagliptin-basal insulin in non-critically ill non-cardiac surgery patients in a real-world setting. METHODS: We enrolled patients w...
Source: Annals of Medicine - May 2, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

Extensive phenotype data and machine learning in prediction of mortality in acute coronary syndrome - the MADDEC study.
Authors: Hernesniemi JA, Mahdiani S, Tynkkynen JA, Lyytikäinen LP, Mishra PP, Lehtimäki T, Eskola M, Nikus K, Antila K, Oksala N Abstract OBJECTIVE: Investigation of the clinical potential of extensive phenotype data and machine learning (ML) in the prediction of mortality in acute coronary syndrome (ACS). METHODS: The value of ML and extensive clinical data was analyzed in a retrospective registry study of 9066 consecutive ACS patients (January 2007 to October 2017). Main outcome was six-month mortality. Prediction models were developed using two ML methods, logistic regression and extreme gradient b...
Source: Annals of Medicine - May 1, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

Low-dose aspirin and risk of upper/lower gastrointestinal bleeding by bleed severity: a cohort study with nested case-control analysis using primary care electronic health records from the United Kingdom.
CONCLUSION: Low-dose aspirin was associated with increased risks of non-fatal but not fatal UGIB/LGIB. Key message Low-dose aspirin is associated with an increased risks of non-fatal UGIB/LGIB but not fatal UGIB/LGIB. PMID: 31025592 [PubMed - as supplied by publisher] (Source: Annals of Medicine)
Source: Annals of Medicine - April 28, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

Adult vaccination as part of a healthy lifestyle: moving from medical intervention to health promotion.
Authors: Mark Doherty T, Del Giudice G, Maggi S Abstract As the global population ages, there is concern about the effect of an increased proportion of older individuals on the economic sustainability of healthcare systems and the social effects of an older society. Health authorities and advocacy groups in countries at the forefront of this trend are now developing strategies to ameliorate the social and financial effects of an ageing population. There is broad agreement that for both society and for the individuals, it is important to ensure that increasing lifespans are matched with increased "healthspans&q...
Source: Annals of Medicine - April 28, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

Microparticles and cardiovascular diseases.
Authors: Voukalis C, Shantsila E, Lip GYH Abstract Microparticles are a distinctive group of small vesicles, without nucleus, which are involved as significant modulators in several physiological and pathophysiological mechanisms. Plasma microparticles from various cellular lines have been subject of research. Data suggest that they are key players in development and manifestation of cardiovascular diseases and their presence, in high levels, is associated with chronic inflammation, endothelial damage and thrombosis. The strong correlation of microparticle levels with several outcomes in cardiovascular diseases has...
Source: Annals of Medicine - April 24, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

Identification of novel variants in ten patients with Hermansky-Pudlak syndrome by high-throughput sequencing.
CONCLUSIONS: Our findings expand the mutational spectrum of HPS, which may help in investigating phenotype-genotype relationships and assist genetic counselling for affected individuals. This approach is a proof of principle that HTS can be considered and used in the first-line diagnosis of patients with biological and clinical manifestations suggestive of HPS. Key messages We established the relationships between the clinical and laboratory phenotype and genotype of six unrelated pedigrees comprising ten patients with clinical suspicion of HPS. Molecular analysis is useful in confirming the diagnosis and may offer some pr...
Source: Annals of Medicine - April 18, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

A 30-year follow-up study of patients with Melkersson-Rosenthal syndrome shows an association to inflammatory bowel disease.
CONCLUSIONS: There was a connection between MRS and IBD - not only CD but ulcerative colitis as well. Key message Melkersson-Rosenthal syndrome (MRS) is a chronic condition often classified as a subtype of orofacial granulomatosis. Oral manifestations are common in MRS. We found a connection between MRS and inflammatory bowel disease, not only Crohn's disease but ulcerative colitis as well. PMID: 30983435 [PubMed - as supplied by publisher] (Source: Annals of Medicine)
Source: Annals of Medicine - April 16, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

The Role of Exosome in Autoimmune Connective Tissue Disease.
Authors: Zhu T, Wang Y, Jin H, Li L Abstract Exosomes have generated significant interest in the last few decades owing to their important roles in a diverse range of biological pathways. They are nano-sized lipid bilayer membrane vesicles of endosomal origin, and are produced by a vast number of cell types. They are released into the extracellular environment and are found in most biological fluids. Exosomes can contain proteins, lipids, and nucleic acids. The cargo of exosomes allows them to play roles in cell communication, antigen presentation, as biomarkers, and in immune regulation. Substantial efforts have b...
Source: Annals of Medicine - April 11, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

Response to commentary by Rhew and colleagues on: Depression, antidepressant use, and risk of venous thromboembolism: systematic review and meta-analysis of published observational evidence.
Authors: Kunutsor SK, Seidu S, Khunti K PMID: 30931634 [PubMed - as supplied by publisher] (Source: Annals of Medicine)
Source: Annals of Medicine - April 2, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

A risk-benefit assessment strategy to exclude cervical artery dissection in spinal manual-therapy: A comprehensive review.
Authors: Chaibi A, Russell MB Abstract Cervical artery dissection refers to a tear in the internal carotid or the vertebral artery that results in an intramural haematoma and/or an aneurysmal dilatation. Although cervical artery dissection is thought to occur spontaneously, physical trauma to the neck, especially hyperextension and rotation, has been reported as a trigger. Headache and/or neck pain is the most common initial symptom of cervical artery dissection. Other symptoms include Horner's syndrome and lower cranial nerve palsy. Both headache and/or neck pain are common symptoms and leading causes of disabilit...
Source: Annals of Medicine - March 20, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

Commentary on: Depression, antidepressant use, and risk of venous thromboembolism: systematic review and meta-analysis of published observational evidence.
Authors: Rhew K, Reams VZ, Brown JD, Winterstein AG PMID: 30801227 [PubMed - as supplied by publisher] (Source: Annals of Medicine)
Source: Annals of Medicine - February 27, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

Celiac Disease: Beyond Genetic Susceptibility and Gluten. A Narrative Review.
Authors: Pes GM, Bibbò S, Dore MP Abstract CONTEXT: Celiac disease (CD) is an immune-mediated disorder triggered by the ingestion of gluten in genetically susceptible individuals. However, only a small proportion of subjects harbouring CD-related genetic risk develop the disease. Among the environmental factors that may influence CD risk, pre- and perinatal factors, delivery methods, parental lifestyle, infant feeding practices, seasonality, dietary factors, drug use, childhood infections and variability in gut microbiota are those most widely studied regarding the risk to develop CD. Although for many of th...
Source: Annals of Medicine - February 13, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

Dietary interventions in Fibromyalgia: a systematic review.
Authors: Silva AR, Bernardo A, Costa J, Cardoso A, Santos P, Mesquita MF, Vaz Patto J, Moreira P, Silva ML, Padrão P Abstract Fibromyalgia (FM) is a chronic non-degenerative disease, whose nutritional therapy seems controversial. This systematic review aimed to synthesize the knowledge about the effect of dietary interventions on patient reported outcomes (PRO) and inflammation in patients with FM. Six electronic databases - PubMed, BioMed Central, Cochrane library, EMBASE, LILACS and ISI - were searched for clinical trials, in which a dietary intervention in patients with FM diagnosed was conducted. Quality...
Source: Annals of Medicine - February 10, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

Cardiovascular Health in Urban Chinese Children and Adolescents.
CONCLUSIONS: The prevalence of ideal cardiovascular health in urban Chinese children and adolescents is extremely low, particularly for physical activity and healthy dietary intake. Effective public health interventions are required to improve cardiovascular health in children and adolescents to reduce future cardiovascular risk. PMID: 30736719 [PubMed - as supplied by publisher] (Source: Annals of Medicine)
Source: Annals of Medicine - February 10, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

Chronic diseases and objectively monitored physical activity profile among aged individuals - a cross-sectional twin cohort study.
CONCLUSIONS: Chronic disease conditions are associated with low PA, which individuals may not always recognize. Shared genetic factors may explain part of the associations. PMID: 30626223 [PubMed - as supplied by publisher] (Source: Annals of Medicine)
Source: Annals of Medicine - January 11, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

Effects of occlusal splints on shoulder strength and activation.
CONCLUSION: OS may provide an advantage for healthy subjects engaged in sports whereby shoulder and arm strength are important for performance. PMID: 30628462 [PubMed - as supplied by publisher] (Source: Annals of Medicine)
Source: Annals of Medicine - January 11, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research

The associations of daylight and melatonin receptor 1B gene rs10830963 variant with glycemic traits: the prospective PPP-Botnia study.
CONCLUSIONS: Our study shows that individual glycemic profiles may vary according to daylight, MTNR1B genotype and their interaction. Future studies may consider taking daylight length into account. PMID: 30592226 [PubMed - as supplied by publisher] (Source: Annals of Medicine)
Source: Annals of Medicine - December 31, 2018 Category: Internal Medicine Tags: Ann Med Source Type: research

Prognostic significance of CDKN2A/B deletions in acute lymphoblastic leukaemia: a meta-analysis.
CONCLUSIONS: Our findings suggested that CDKN2A/B deletions were associated with poor prognosis independently in both adult and childhood ALL patients. Inclusion of CDKN2A/B status may further improve the risk stratification of ALL patients. PMID: 30592434 [PubMed - as supplied by publisher] (Source: Annals of Medicine)
Source: Annals of Medicine - December 31, 2018 Category: Internal Medicine Tags: Ann Med Source Type: research

Use of Antihypertensive Medication after Ischemic Stroke in Young Adults and its Association with Long-term Outcome.
CONCLUSIONS: Use of antihypertensives was suboptimal in one third of patients in whom antihypertensives were initially prescribed. Users were at lower risk of mortality and recurrent stroke or TIA compared to non-users. PMID: 30592437 [PubMed - as supplied by publisher] (Source: Annals of Medicine)
Source: Annals of Medicine - December 31, 2018 Category: Internal Medicine Tags: Ann Med Source Type: research

Editorial.
Authors: Alves de Matos AP PMID: 30580644 [PubMed - as supplied by publisher] (Source: Annals of Medicine)
Source: Annals of Medicine - December 27, 2018 Category: Internal Medicine Tags: Ann Med Source Type: research

Correction.
Authors: PMID: 30461317 [PubMed - as supplied by publisher] (Source: Annals of Medicine)
Source: Annals of Medicine - November 22, 2018 Category: Internal Medicine Tags: Ann Med Source Type: research

Title: Dietary Sodium Intake is Associated with Long-Term Risk of New-Onset Atrial Fibrillation.
CONCLUSIONS: These findings indicate that sodium intake is associated with the long-term risk of new-onset AF. Further confirmatory studies are needed. PMID: 30442022 [PubMed - as supplied by publisher] (Source: Annals of Medicine)
Source: Annals of Medicine - November 18, 2018 Category: Internal Medicine Tags: Ann Med Source Type: research

Update on Extended Treatment for Venous Thromboembolism.
Authors: Peñaloza-Martínez E, Demelo-Rodríguez P, Proietti M, Soria Fernández-Llamazares G, Llamazares-Mendo C, Álvarez-Sala Walther L, Marra AM, Del Toro-Cervera J Abstract The importance of assessing the probability of venous thromboembolism recurrence, a condition that includes deep vein thrombosis and pulmonary embolism, lies in the fact that it is the most important factor in deciding the duration of anticoagulant treatment. Risk of recurrence depends mostly on the presence of a risk factor for developing venous thromboembolism, with patients with unprovoked events being at t...
Source: Annals of Medicine - October 23, 2018 Category: Internal Medicine Tags: Ann Med Source Type: research

Efficacy and safety of intravenous esmolol for cardiac protection in non-cardiac surgery. A systematic review and meta-analysis.
Authors: Ollila A, Vikatmaa L, Sund R, Pettilä V, Wilkman E Abstract Haemodynamic instability predisposes patients to cardiac complications in non-cardiac surgery. Esmolol, a short-acting cardio selective beta adrenergic blocker might be efficient in perioperative cardiac protection, but could affect other vital organs, such as the kidneys, and post-discharge survival. We performed a systematic review on the use of esmolol for perioperative cardiac protection. We searched PubMed, Ovid Medline and Cochrane Central Register for Controlled trials. Eligible randomised controlled studies (RCTs) reported a periopera...
Source: Annals of Medicine - October 23, 2018 Category: Internal Medicine Tags: Ann Med Source Type: research

The association between exposure to second-hand smoke and major depressive disorder in perimenopausal women: results from a population-based study.
CONCLUSIONS: The present study results augment our understanding of the clinical and public health significance of SHS, as well as the role of various socioeconomic and self-rated health conditions, in perimenopausal women. PMID: 30311809 [PubMed - as supplied by publisher] (Source: Annals of Medicine)
Source: Annals of Medicine - October 13, 2018 Category: Internal Medicine Tags: Ann Med Source Type: research

Risk of preterm birth in primiparous women with exposure to antidepressant medication before pregnancy and/or during pregnancy - impact of body mass index.
Authors: Laine MK, Masalin S, Rönö K, Kautiainen H, Gissler M, Pennanen P, Eriksson JG Abstract INTRODUCTION: Preterm birth is a major cause of infant mortality. It is unknown whether body mass index (BMI) influences the risk of preterm birth in women who prenatally use antidepressants. MATERIALS AND METHODS: The study cohort (N = 6920) consists of all primiparous European born women without previously diagnosed diabetes from the city of Vantaa, Finland, who delivered a singleton child between 2009 and 2015. Data on births, pre-pregnancy BMI, and purchases of antidepressants from 12 mont...
Source: Annals of Medicine - October 11, 2018 Category: Internal Medicine Tags: Ann Med Source Type: research

The Validation of Smartphone Applications for Heart Rate Measurement.
CONCLUSIONS: HR measurements from all applications were correlated well with ECG monitoring. However, it was less accurate in case of irregular rhythm such as atrial fibrillation. PMID: 30269602 [PubMed - as supplied by publisher] (Source: Annals of Medicine)
Source: Annals of Medicine - October 3, 2018 Category: Internal Medicine Tags: Ann Med Source Type: research

Corrigendum.
Authors: PMID: 30269608 [PubMed - as supplied by publisher] (Source: Annals of Medicine)
Source: Annals of Medicine - October 3, 2018 Category: Internal Medicine Tags: Ann Med Source Type: research

Cardiac Troponin - Diagnostic Problems and Impact on Cardiovascular Disease.
Authors: Alaour B, Liew F, Kaier TE Abstract The definition of a high-sensitivity cardiac Troponin (cTn) assay describes the ability to quantify a cardiac biomarker level in at least 50% of healthy individuals. This advance in analytic sensitivity has come with a perceived loss of specificity in the most classic application - chest pain triage and the diagnosis of acute myocardial infarction (AMI). As cardiac Troponin can no longer be used as a dichotomous test, the medical field is increasingly moving towards a more granular interpretation. However, rapid rule-out/rule-in algorithms for AMI still rely on concrete ...
Source: Annals of Medicine - September 29, 2018 Category: Internal Medicine Tags: Ann Med Source Type: research

Prospects for Circadian Treatment of Mood Disorders.
Authors: Hühne A, Welsh DK, Landgraf D Abstract Disruption of circadian clocks is strongly associated with mood disorders. "Chronotherapies" targeting circadian rhythms have been shown to be very effective treatments of mood disorders, but still are not widely used in clinical practice. The mechanisms by which circadian disruption leads to mood disorders are poorly characterized and therefore may not convince clinicians to apply chronotherapies. Hence, in this review, we describe specific potential mechanisms, in order to make this connection more credible to clinicians. We believe that four major fe...
Source: Annals of Medicine - September 29, 2018 Category: Internal Medicine Tags: Ann Med Source Type: research

Prevalence, incidence and mortality of inflammatory bowel disease in Catalonia. A population-based analysis.
CONCLUSIONS: IBD prevalence is very high and is increasing rapidly in Catalonia. Both CD and UC are associated with significantly higher mortality rates. PMID: 30247071 [PubMed - as supplied by publisher] (Source: Annals of Medicine)
Source: Annals of Medicine - September 26, 2018 Category: Internal Medicine Tags: Ann Med Source Type: research

Invasive Pulmonary Aspergillosis in Patients with Solid Tumors: Risk Factors and Predictors of Clinical Outcomes.
Authors: Dandachi D, Wilson Dib R, Fernández-Cruz A, Jiang Y, Chaftari AM, Hachem R, Raad I Abstract BACKGROUND: The characteristics and management of invasive pulmonary aspergillosis (IPA) in patients with hematologic malignancies are well known, but IPA in patients with solid tumors is not well described. METHODS: We retrospectively reviewed all Aspergillus-positive cultures at a tertiary cancer center during 2004-2017. We identified 101 patients with IPA and solid tumors. We analyzed the association between clinical features and treatment and 12-week mortality and response to antifungal therapy. R...
Source: Annals of Medicine - September 21, 2018 Category: Internal Medicine Tags: Ann Med Source Type: research

Triglyceride glucose and hemoglobin glycation index for predicting outcomes in diabetes patients with new-onset, stable coronary artery disease: a nested case-control study.
CONCLUSION: Both TyG index and HGI could predict cardiovascular outcomes in T2DM patients with new-onset, stable CAD while TyG index might be better. PMID: 30207490 [PubMed - as supplied by publisher] (Source: Annals of Medicine)
Source: Annals of Medicine - September 13, 2018 Category: Internal Medicine Tags: Ann Med Source Type: research

Cardioversion for Atrial Fibrillation - How to Prevent Thromboembolic Complications?
Authors: Jaakkola S, Kiviniemi TO, Airaksinen KEJ Abstract Cardioversion is an essential component of rhythm control strategy for atrial fibrillation. The thromboembolic risk of cardioversion is well established and the mechanisms behind the phenomenon have been comprehensively described. There are several clinical aspects that are important to take into consideration when assessing the safety of cardioversion. Before proceeding to cardioversion, the probability of early treatment failure and antiarrhythmic treatment options to prevent recurrences should be carefully evaluated to avoid the risks of repeated futile ...
Source: Annals of Medicine - September 13, 2018 Category: Internal Medicine Tags: Ann Med Source Type: research