Time-course analysis reveals that corticosteroids resuscitate diminished CD8+ T cells in COVID-19: a retrospective cohort study.
CONCLUSION: The parameters of coagulation, inflammation and immunity were longitudinally correlated, and an early low-dose corticosteroid treatment accelerated the regaining of CD8+ T cell to help battle against SARS-Cov-2 in critical cases of COVID-19. PMID: 33183091 [PubMed - as supplied by publisher] (Source: Annals of Medicine)
Source: Annals of Medicine - November 17, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Admission hyperglycaemia as a predictor of mortality in patients hospitalized with COVID-19 regardless of diabetes status: data from the Spanish SEMI-COVID-19 Registry.
Authors: Carrasco-Sánchez FJ, López-Carmona MD, Martínez-Marcos FJ, Pérez-Belmonte LM, Hidalgo-Jiménez A, Buonaiuto V, Suárez Fernández C, Freire Castro SJ, Luordo D, Pesqueira Fontan PM, Blázquez Encinar JC, Magallanes Gamboa JO, de la Peña Fernández A, Torres Peña JD, Fernández Solà J, Napal Lecumberri JJ, Amorós Martínez F, Guisado Espartero ME, Jorge Ripper C, Gómez Méndez R, Vicente López N, Román Bernal B, Rojano Rivero MG, Ramos Rincón JM, Gómez Huelgas R, SEMI-COVID-19 N...
Source: Annals of Medicine - November 14, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Corrigendum to "Iatrogenic nerve lesion following laparoscopic surgery. A case report ˮ [Ann. Med. Surg. 28 (2018) 34-37].
Corrigendum to "Iatrogenic nerve lesion following laparoscopic surgery. A case reportˮ [Ann. Med. Surg. 28 (2018) 34-37]. Ann Med Surg (Lond). 2020 Nov;59:286 Authors: Vecchio M, Santamato A, Genovese F, Malaguarnera G, Catania VE, Latteri S Abstract [This corrects the article DOI: 10.1016/j.amsu.2018.02.002.]. PMID: 33133583 [PubMed] (Source: Annals of Medicine)
Source: Annals of Medicine - November 4, 2020 Category: Internal Medicine Tags: Ann Med Surg (Lond) Source Type: research

Disparities in Case Frequency and Mortality of Coronavirus Disease 2019 (COVID-19) Among Various States in the United States.
Authors: Loomba RS, Aggarwal G, Aggarwal S, Flores S, Villarreal EG, Farias JS, Lavie CJ Abstract OBJECTIVE: To utilize publicly reported, state-level data to identify factors associated with the frequency of cases, tests, and mortality in the US. MATERIALS & METHODS: Retrospective study using publicly reported data collected included the number of COVID-19 cases, tests, and mortality from March 14th through April 30th. Publicly available state-level data was collected which included: demographics comorbidities, state characteristics and environmental factors. Univariate and multivariate regression analyses...
Source: Annals of Medicine - November 4, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

The expanding role of SGLT2 inhibitors beyond glucose-lowering to cardiorenal protection.
Authors: Brown E, Wilding JP, Alam U, Barber TM, Karalliedde J, Cuthbertson DJ Abstract The kidney plays a major physiological role in glucose homeostasis but also contributes to the pathophysiology of type 2 diabetes (T2D), mediated by renal sodium glucose cotransporters (SGLTs). This recognition led to development of SGLT2 inhibitors that inhibit proximal renal tubular renal glucose and sodium reabsorption. The glucoretic and natriuretic effect of SGLT2 inhibitors is associated with reductions in HbA1c levels, body weight, systolic blood pressure and triglycerides. Major vascular complications of T2D include card...
Source: Annals of Medicine - October 28, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Diagnostic role of circulating MiR-21 in colorectal cancer: a update meta-analysis.
CONCLUSION: Our meta-analysis results suggest that circulating miR-21 has a potential diagnostic value with moderate sensitivity and good specificity for CRC. PMID: 33108223 [PubMed - as supplied by publisher] (Source: Annals of Medicine)
Source: Annals of Medicine - October 28, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Hydroxychloroquine: A comprehensive review and its controversial role in coronavirus disease 2019.
Authors: Bansal P, Goyal A, Cusick A, Lahan S, Dhaliwal HS, Bhyan P, Bhattad PB, Aslam F, Ranka S, Dalia T, Chhabra L, Sanghavi D, Sonani B, M Davis J Abstract Hydroxychloroquine, initially used as an antimalarial, is used as an immunomodulatory and anti-inflammatory agent for the management of autoimmune and rheumatic diseases such as systemic lupus erythematosus. Lately, there has been interest in its potential efficacy against severe acute respiratory syndrome coronavirus 2, with several speculated mechanisms.The purpose of this review is to elaborate on the mechanisms surrounding hydroxychloroquine. The review ...
Source: Annals of Medicine - October 25, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Admission hyperglycemiaas a predictor of mortality in patients hospitalized with COVID-19 regardless of diabetes status: Data from the Spanish SEMI-COVID-19 Registry.
Authors: Carrasco-Sánchez FJ, López-Carmona MD, Martínez-Marcos FJ, Pérez-Belmonte LM, Hidalgo-Jiménez A, Buonaiuto V, Suárez Fernández C, Freire Castro SJ, Luordo D, Pesqueira Fontan PM, Blázquez Encinar JC, Magallanes Gamboa JO, de la Peña Fernández A, Torres Peña JD, Fernández Solà J, Napal Lecumberri JJ, Amorós Martínez F, Guisado Espartero ME, Jorge Ripper C, Gómez Méndez R, Vicente López N, Román Bernal B, Rojano Rivero MG, Ramos Rincón JM, Gómez Huelgas R, SEMI-COVID-19 N...
Source: Annals of Medicine - October 20, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Bacterial and viral infections and related inflammatory responses in Chronic Obstructive Pulmonary Disease.
Authors: D'Anna SE, Maniscalco M, Cappello F, Carone M, Motta A, Balbi B, Ricciardolo FM, Caramori G, Di Stefano A Abstract In COPD patients, bacterial and viral infections play a relevant role in worsening lung function and, therefore, favor disease progression. The inflammatory response to lung infections may become a specific indication of the bacterial and viral infections. We here review data on the bacterial-viral infections and related airways and lung parenchyma inflammation in stable and exacerbated COPD, focusing our attention on the prevalent molecular pathways in these different clinical conditions. The...
Source: Annals of Medicine - October 2, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

External Validation of a Clinical Risk Score to Predict Hospital Admission and In-Hospital Mortality in COVID-19 Patients.
Authors: Halalau A, Imam Z, Karabon P, Mankuzhy N, Shaheen A, Tu J, Carpenter C Abstract Background: Identification of patients with novel coronavirus disease 2019 (COVID-19) requiring hospital admission or at high-risk of in-hospital mortality is essential to guide patient triage and to provide timely treatment for higher risk hospitalized patients.Methods: A retrospective multi-center (8 hospital) cohort at Beaumont Health, Michigan, USA, reporting on COVID-19 patients diagnosed between March 1 and April 1, 2020 was used for score validation. The COVID-19 Risk of Complications Score was automatically computed by ...
Source: Annals of Medicine - October 2, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Demographics, comorbidities and outcomes in hospitalized Covid-19 patients in rural southwest Georgia.
This study aimed to describe the demographics, and outcomes of hospitalized Covid-19 patients in rural Southwest Georgia. METHODS: Using electronic medical records, we analyzed data from all hospitalized Covid-19 patients who either died or survived to discharge between 2 March 2020 and 6 May 2020. RESULTS: Of the 522 patients, 92 died in hospital (17.6%). Median age was 63 years, 58% were females, and 87% African-Americans. Hypertension (79.7%), obesity (66.5%) and diabetes mellitus (42.3%) were the most common comorbidities. Males had higher overall mortality compared to females (23 v 13.8%). Immunosuppres...
Source: Annals of Medicine - September 22, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Outcome of acute myocardial infarction versus stable coronary artery disease patients treated with coronary bypass surgery.
Authors: Malmberg M, Gunn J, Rautava P, Sipilä J, Kytö V Abstract Long-term outcome differences between acute myocardial infarction (MI) and stable coronary artery disease (CAD) patients treated with coronary artery bypass grafting (CABG) are poorly known. We studied retrospectively patients with MI (n = 1882) or stable CAD (n = 13117) treated with isolated CABG between 2004-2014. Inverse propensity probability weight adjustment for baseline features was used. Median follow-up was 7.9 years. In-hospital mortality (8.6% vs. 1.6%; OR 5.94; p 
Source: Annals of Medicine - September 4, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Handgrip strength improves prediction of type 2 diabetes: A prospective cohort study.
Conclusion: Adding measurements of HGS to conventional risk factors might improve T2D risk assessment, especially in women. Further evaluation is needed in larger studies. KEY MESSAGESHandgrip strength (HGS) is independently associated with reduced risk of type 2 diabetes (T2D), but its utility in classifying or predicting T2D risk has not been explored.In this prospective cohort study of older Caucasian men and women, adding measurements of HGS to conventional risk factors improved T2D risk assessment, especially in women.Assessment of HGS is simple and inexpensive and could prove a valuable clinical tool in the early ide...
Source: Annals of Medicine - August 26, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Important role of microglia in HIV-1 associated neurocognitive disorders and the molecular pathways implicated in its pathogenesis.
Authors: Borrajo A, Spuch C, Penedo MA, Olivares JM, Agís-Balboa RC Abstract The development of effective combined anti-retroviral therapy (cART) led to a significant reduction in the death rate associated with human immunodeficiency virus type 1 (HIV-1) infection. However, recent studies indicate that considerably more than 50% of all HIV-1 infected patients develop HIV-1-associated neurocognitive disorder (HAND). Microglia are the foremost cells infected by HIV-1 in the central nervous system (CNS), and so, are also likely to contribute to the neurotoxicity observed in HAND. The activation of microglia ind...
Source: Annals of Medicine - August 26, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Changes in serum virus-specific IgM/IgG antibody in asymptomatic and discharged patients with reoccurring positive COVID-19 nucleic acid test (RPNAT).
This study aims to investigate these IgM/IgG changes.Methods There were 111 patients with positive nucleic acid test (NAT) and 40 suspected patients enrolled in the study. The serum SARS-CoV-2 specific IgM/IgG antibody levels were retrospectively analyzed with the disease progress in asymptomatic and RPNAT patients.Results The best overall performance was found by combining the IgM, IgG, and CT; 95.1% sensitivity and 75% specificity. This was tested in 111 RT-PCR positive cases. The median IgM and IgG levels were lower in the asymptomatic group compared to the symptomatic group (P
Source: Annals of Medicine - August 20, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Title: Cytomegalovirus antibody levels and mortality among hospitalized elderly patients.
Conclusions: Increased IgG antibody levels against CMV are associated with increased short and long-term mortality in elderly hospitalized patients, especially in the patients without cardiovascular disease. PMID: 32803995 [PubMed - as supplied by publisher] (Source: Annals of Medicine)
Source: Annals of Medicine - August 19, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Clinical and pharmacological characteristics of elderly patients admitted for bleeding: impact on in-hospital mortality.
Authors: Pani A, Pastori D, Senatore M, Romandini A, Colombo G, Agnelli F, Scaglione F, Colombo F Abstract INTRODUCTION: Clinical and pharmacological characteristics of elderly patients hospitalised for bleeding and in-hospital mortality according to bleeding type are barely described.METHODS: Retrospective cohort study of 13,496 consecutive patients admitted to Internal Medicine wards. Clinical characteristics, comorbidities and pharmacological treatments were collected for each patient. Predictors of in-hospital mortality were investigated.RESULTS: Overall, 531 (3.9%) patients were admitted for bleeding: 189 clin...
Source: Annals of Medicine - August 17, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Challenges in diagnosing head and neck cancer in primary health care.
Conclusions: Despite the low incidence of HNC and the large number of patients presenting with HNC-related symptoms, GPs working in PHC sort out potential HNC patients from the general patient group in most cases remarkably effectively. Key messages:For every head and neck cancer patient encountered in the primary health care, a general practitioner will meet approximately 6000 other patients, 100 of whom exhibit a sign or a symptom potentially caused by a head and neck cancer.Despite the low incidence of head and neck cancer, general practitioners referred patients to specialistcare effectively, limiting the median delay ...
Source: Annals of Medicine - August 13, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Erratum to "Is the lockdown important to prevent the COVID-19 pandemic? Effects on psychology, environment and economy-perspective" [Ann. Med. Surg. 56 (2020) 38-42].
Erratum to "Is the lockdown important to prevent the COVID-19 pandemic? Effects on psychology, environment and economy-perspective" [Ann. Med. Surg. 56 (2020) 38-42]. Ann Med Surg (Lond). 2020 08;56:217 Authors: Atalan A Abstract [This corrects the article DOI: 10.1016/j.amsu.2020.06.010.]. PMID: 32754311 [PubMed] (Source: Annals of Medicine)
Source: Annals of Medicine - August 13, 2020 Category: Internal Medicine Tags: Ann Med Surg (Lond) Source Type: research

Characterisation of clinical, laboratory and imaging factors related to mild vs. severe covid-19 infection: a systematic review and meta-analysis.
Conclusions and Relevance: Our findings offer guidance for a wide spectrum of clinicians to early identify severe COVID-19 patients, transport to specialised centres, and initiate appropriate treatment. Key Messages This systematic review and meta-analysis examined 41 studies including 5,064 patients with confirmed COVID-19. Severe cases were associated with age, male gender, and with fever, cough and respiratory diseases, increased WBC, CRP, D-dimer, AST and LDH levels. Furthermore, CT manifestation of bilateral lung involvement was associated with the severe cases. These findings provide guidance to health professionals ...
Source: Annals of Medicine - August 13, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Gut Microbes in Neurocognitive and Mental Health Disorders.
Conclusions: This understanding can open up the need for a gut related approach in these disorders as well as unlock the door for the role of gut related microbiota management. Key Messages:Challenges of managing mental health conditions remain in spite of new pharmacological therapy.Gut dysbiosis is seen in various mental health conditions.Various psychotropic medications can have an influence on the gut microbiota by their antimicrobial effect. PMID: 32772900 [PubMed - as supplied by publisher] (Source: Annals of Medicine)
Source: Annals of Medicine - August 13, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Why is COVID-19 Especially Impacting the African American Population?
Authors: Sanchis-Gomar F, Lippi G, Lavie CJ PMID: 32776788 [PubMed - as supplied by publisher] (Source: Annals of Medicine)
Source: Annals of Medicine - August 13, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Personalized medicine in Hypercholesterolemia: The Role of Pharmacogenetics in Statin Therapy.
Authors: Ahangari N, Doosti M, Ghayour Mobarhan M, Sahebkar A, Ferns GA, Pasdar A Abstract Statins are the first-line choice in Lipid-lowering therapy to reduce cardiovascular risk. In a continuous attempt to optimize treatment success, there is a need for additional research on genes and related molecular pathways that can determine theefficacy and toxicity of lipid-lowering drugs. Several variations within genes associated with lipid metabolism, including those involved in uptake, distribution and metabolism of statins have been reported. The purpose of this study was to evaluate the effect of genetic variationsi...
Source: Annals of Medicine - August 2, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Lifestyle counselling by persuasive information and communications technology reduces prevalence of metabolic syndrome in a dose-response manner: a randomized clinical trial (PrevMetSyn).
CONCLUSIONS: Web-based ICT is able to reduce the prevalence of MetS. In addition, higher utilization of the web information system is associated with a greater decrease in the prevalence of MetS. Key messages Our internet health behaviour change support system based on persuasive design and cognitive behaviour therapy markedly reduces metabolic syndrome in overweight/obese subjects. As a stand-alone tool it may save healthcare personnel resources as it is suitable at a low cost for both obese/overweight patients and the public at large. PMID: 32727302 [PubMed - in process] (Source: Annals of Medicine)
Source: Annals of Medicine - July 31, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Comparing Oscillometric and Tonometric Methods to Assess Pulse Wave Velocity: a population-based study.
Conclusions.Oscillometric PWV estimates provide reliable values in the general population. An o-PWV tendency to underestimate arterial stiffness in younger subjects and in subjects with diseases known to increase arterial stiffness and to overestimate it with increasing age was found, even if scarcely relevant in clinical perspective. Overall the present findings underline an acceptable and satisfactory agreement between oscillometric and tonometric methods for the PWV assessment. Key messagesOscillometric and tonometric PWV estimates showed a good and satisfactory agreement in the general population, above all in subjects...
Source: Annals of Medicine - July 31, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

A nomogram to predict the risk of unfavourable outcome in COVID-19: a retrospective cohort of 279 hospitalized patients in Paris area.
Conclusion. We identified seven easily available prognostic factors and proposed a simplenomogram for early detection of patients at risk of aggravation,inorder to optimize clinical care and initiate specific therapies. Key MessagesSince novel coronavirus disease 2019 pandemic, a minority of patients develops severe respiratory distress syndrome, leading to death despite intensive care. Tools to identify patients at risk in European populations are lacking.In our series, age, respiratory rate, overweight, temperature, C-reactive protein, troponin and lymphocyte counts were risk factors of an unfavourable outcome in hospita...
Source: Annals of Medicine - July 30, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Hypertension is a risk factor for adverse outcomes in patients with coronavirus disease 2019: a cohort study.
Authors: Xiong TY, Huang FY, Liu Q, Peng Y, Xu YN, Wei JF, Li N, Bai B, Li JH, Prendergast B, Li WM, Chen M Abstract Background: Comorbidities are commonly seen in patients with coronavirus disease 2019 (COVID-19), but the clinical implication is not yet well-delineated. We aim to characterize the prevalence and clinical implications of comorbidities in patients with COVID-19.Methods: This is a retrospective multi-center study involving patients admitted between January 16th and March 10th 2020.The composite endpoint was defined as the presence of at least one of the following, intensive care unit (ICU) admission, ...
Source: Annals of Medicine - July 29, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Heart type fatty acid binding protein: An overlooked cardiac biomarker.
Authors: Goel H, Melot J, Krinock MD, Kumar A, Nadar SK, Lip GYH Abstract Cardiac troponins (cTn) are currently the standard of carefor the diagnosis of acute coronary syndromes (ACS) in patients presenting to the emergency department (ED) with chest pain (CP). However, their plasma kinetics necessitatea prolonged ED stay or overnight hospital admission, especially in those presenting early after CP onset. Moreover, ruling out ACS in low-risk patients requires prolonged ED observationor overnight hospital admission to allow serialmeasurements of c-Tn, adding cost. Heart-type fatty acid-binding protein (H-FABP) is a...
Source: Annals of Medicine - July 24, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Impact of multimorbidity and polypharmacy on the management of patients with atrial fibrillation: Insights from the BALKAN-AF survey.
Conclusions Multimorbidity and polypharmacy were common among AF patients in our study. AT was suboptimal and approximately 18% of multimorbid patients with polypharmacy were not anticoagulated. Pattern of AF and non-emergency centre were associated with OAC non-use in AF patients with multimorbidity, whilst non-emergency centre and age ≥80 years were associated with OAC non-use in AF patients with polypharmacy. Key messages:Multimorbidity and polypharmacy are common among patients with AF.Antithrombotic therapy was suboptimal in AF patients with multimorbidity and polypharmacy.Approximately 18% of multimorbid patients ...
Source: Annals of Medicine - July 24, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Is interleukin-2 an optimal marker for diagnosing tuberculosis infection? A systematic review and meta-analysis.
Conclusions: These findings showed that IL-2 is a powerful marker for differentiating LTBI from non-TB controls and a good marker for differentiating ATB from LTBI individuals. PMID: 32700645 [PubMed - as supplied by publisher] (Source: Annals of Medicine)
Source: Annals of Medicine - July 24, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Healthy lifestyle and cancer risk among Chinese population in the Dongfeng-Tongji Cohort.
Conclusions: The current study suggests that healthy lifestyle could reduce cancer risk in the retired Chinese population, especially in males. Key Messages:Healthy lifestyle derived by smoking, drinking, diet, body mass index and physical activity presented a strong protective effect on cancer risk among the retired Chinese population, especially in males.We employed the rate advancement periods and the population attributable risk percentage to indicate the benefits of adopting healthy lifestyle and we found that following all healthy lifestyle factors could delay the risk of developing cancer by 9.14 years and prevent 1...
Source: Annals of Medicine - July 21, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Serum uric acid and risk of incident hypercholesterolemia and hypertriglyceridemia in middle-aged and older Chinese: a 4-year prospective cohort study.
Conclusions: These findings suggest that SUA may be positively associated with incident hypertriglyceridemia. Key Messages:The natural cubic spline model showed a positive linear dose-response relationship between serum uric acid levels and hypertriglyceridemia.Compared with the quartile 1 of SUA, the adjusted risk ratios (95% confidence interval) of hypertriglyceridemia were 1.15 (0.95-1.39), 1.23 (1.02-1.49) and 1.31 (1.08-1.59) for quartile 2-4 (P-value for trend =0.004), respectively.Sex-stratified analyses indicated that the association of serum uric acid with hypertriglyceridemia was more evident in the female. P...
Source: Annals of Medicine - July 14, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Deep learning-based automatic blood pressure measurement: evaluation of the effect of deep breathing, talking and arm movement.
This study aims to evaluate the performance of using deep learning-based method to measure BPs and BP change under non-resting conditions.Materials and methods: Forty healthy subjects were studied. Systolic and diastolic BPs (SBPs and DBPs) were measured under four conditions using deep learning and manual auscultatory method. The agreement between BPs determined by the two methods were analysed under different conditions. The performance of using deep learning-based method to measure BP changes was finally evaluated.Results: There were no significant BPs differences between two methods under all measurement conditions (al...
Source: Annals of Medicine - July 10, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Renal complications in COVID-19: A systematic review and meta-analysis.
Conclusions: Frequent renal complicationsreported among hospitalised COVID-19 patientsare electrolyte disturbance, AKI and RRT. Aggressive monitoring and management of these renal complications may help in the prediction of favourable outcomes.Systematic review registration: PROSPERO 2020: CRD42020186873 Key messagesCOVID-19 affects multiple organs apart from the respiratory system; however, its renal manifestations are not clearly defined.In this systematic meta-analysis of 22 observational cohort studies, the prevalence of pre-existing chronic kidney disease (CKD) in COVID-19 patients was5.2%.The most frequent renal comp...
Source: Annals of Medicine - July 10, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Differential biomarker profiles between unprovoked venous thromboembolism and cancer.
CONCLUSIONS: Levels of TF-positive EVs, D-dimer and sP-selectin are able to discriminate between unprovoked VTD patients not related to cancer and cancer patients not associated with VTD. These results could lead to the application of EVs as biomarkers of both diseases.Key Messages: Circulating EVs, specifically TF-positive EVs, in combination with plasmatic markers of hypercoagulable states, such as D-dimer, sP-selectin and antigen TF, are able to discriminate between cancer patients without thrombosis and patients with unprovoked VTD. Research fields could be opened. Future studies will assess if these biomarkers togethe...
Source: Annals of Medicine - July 9, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Demographics, Comorbidities, and Outcomes in Hospitalized Covid-19 Patients in Rural Southwest Georgia.
This study aimed to describe the demographics, and outcomes of hospitalized Covid-19 patients in rural Southwest Georgia.Methods: Using electronic medical records, we analyzed data from all hospitalized Covid-19 patients who either diedor survived to discharge between March 2, 2020 and May 6, 2020.Results: Of the 522 patients, 92 died in hospital (17.6%). Median age was 63 years, 58% were females, and 87% African-Americans. Hypertension (79.7%), obesity (66.5%), and diabetes mellitus (42.3%) were the most common comorbidities. Males had higher overall mortality compared to females (23% v 13.8%). Immunosuppression [odds rat...
Source: Annals of Medicine - July 7, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

COVID-19 and venous thromboembolism: current insights and prophylactic strategies.
Authors: Ambrosino P, Di Minno A, Maniscalco M, Di Minno MND Abstract The rapidly increasing number of studies on the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) indicate that this viral agent can cause the coronavirus disease 2019 (COVID-19), a syndrome with a wide spectrum of clinical presentations, ranging from a mild disease with flu-like symptoms to a life-threatening condition that requires specialized management at Intensive Care Units (ICU). Critical patients with COVID-19 have a high risk of thromboembolic complications, as expressed by a Padua prediction score always ≥4. Moreover...
Source: Annals of Medicine - July 4, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Effect of vaccination on the use of antimicrobial agents: a systematic literature review.
Conclusions and implications of key findings: Despite the limitations of the review, the evidence indicates that improved coverage with existing vaccines may significantly reduce antimicrobial demand. This suggests it may be a valuable tool for antimicrobial stewardship.Key messagesWhile vaccines against a number of pathogens have been studied for their ability to reduce antimicrobial use, currently only vaccination against influenza or pneumococcus has generated sufficient data for analysisVaccination against either influenza or pneumococcus significantly reduced overall antimicrobial prescribing rates, both in vaccinated...
Source: Annals of Medicine - July 2, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

24-h urinary sodium excretion and the risk of adverse outcomes.
Conclusion: High sodium intake is associated with an increased incidence of CVD and DM. PMID: 32602794 [PubMed - as supplied by publisher] (Source: Annals of Medicine)
Source: Annals of Medicine - July 2, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Vasculitides and glomerulonephritis associated with Staphylocococcus aureus infective endocarditis: cases reports and mini-review  of the literature.
We reported two cases of Staphylococcus aureus Infective Endocarditis associated with vasculitides and glomerulonephritis respectively, before conducting an online search of previously published similar cases reports. Twenty five references were selected: 15 cases of glomerulonephritis; 2 cases of vasculitis and 8 cases involving both glomerulonephritis and vasculitis. Vasculitides and glomerulonephritis associated with Staphylococcus aureus definite Infective Endocarditis have been reported since 1976. All cases except one described clinical symptoms occurring before or during initial antibiotics treatment. Except kidney,...
Source: Annals of Medicine - June 27, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Inverse time trends of peptic ulcer and reflux esophagitis show significant association with reduced prevalence of Helicobacter pylori infection.
Conclusions: The prevalence of GU and DU has gradually decreased whereas that of RE has markedly increased in Japan. Inverse time trends of peptic ulcer and reflux esophagitis are significantly associated with reduced prevalence of HP infection. Key Messages:The prevalence of gastric and duodenal ulcer has gradually decreased whereas that of reflux esophagitis has markedly increased in Japan.The prevalence of Helicobacter pylori infection in Japan has greatly decreased from 49.8% to 31.2% during the 14 years (from 1996 to 2010).Inverse time trends of peptic ulcer and reflux esophagitis are associated with reduced prevalenc...
Source: Annals of Medicine - June 17, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

NEWS and qSIRS superior to qSOFA in the prediction of 30-day mortality in emergency department patients in Hong Kong.
Conclusions: Among unselected emergency and urgent ED patients, the prognostic value for NEWS and qSIRS were greater than qSOFA, Combinations of qSOFA and SIRS could improve the predictive value for 30-day mortality for ED patients. Key Messages:NEWS ≥5 and qSIRS ≥2 were better than qSOFA ≥2 at predicting 30-day mortality in ED patients.Combinations of qSOFA and SIRS could improve the predictive value for 30-day mortality for ED patients. PMID: 32530356 [PubMed - as supplied by publisher] (Source: Annals of Medicine)
Source: Annals of Medicine - June 13, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Unravelling the health effects of fasting: a long road from obesity treatment to healthy life span increase and improved cognition.
Authors: Wilhelmi de Toledo F, Grundler F, Sirtori CR, Ruscica M Abstract In recent years a revival of interest has emerged in the health benefits of intermittent fasting and long-term fasting, as well as of other related nutritional strategies. In addition to meal size and composition a new focus on time and frequency of meals has gained attention. The present review will investigate the effects of the main forms of fasting, activating the metabolic switch from glucose to fat and ketones (G-to-K), starting 12-16 h after cessation or strong reduction of food intake. During fasting the deactivation of mTOR re...
Source: Annals of Medicine - June 12, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Relationship of adverse events to quality of anticoagulation control in atrial fibrillation patients with diabetes: Real-world data from the FANTASIIA registry.
Authors: García-Fernández A, Esteve-Pastor MA, Rabadán IR, Muñiz J, Ruiz Ortiz M, Cequier Á, Bertomeu-Martínez V, Badimón L, Otero D, Anguita M, Lip GYH, Marín F Abstract BACKGROUND: Atrial fibrillation (AF) patients with diabetes (DM) are at increased risk of cardiovascular events and have higher related morbidity and mortality. PURPOSE: To compare clinical characteristics, cardiovascular adverse outcomes and quality of anticoagulation in AF patients with and without DM. METHODS: AF patients from the Spanish national, multicentric, prospective FANTASI...
Source: Annals of Medicine - June 7, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Lipoprotein(a) in atherosclerosis: from pathophysiology to clinical relevance and treatment options.
Authors: Rehberger Likozar A, Zavrtanik M, Šebeštjen M Abstract Lipoprotein(a) (Lp(a)) was discovered more than 50 years ago, and a decade later, it was recognized as a risk factor for coronary artery disease. However, it has gained importance only in the past 10 years, with emergence of drugs that can effectively decrease its levels. Lp(a) is a low-density lipoprotein with an added apolipoprotein(a) attached to the apolipoprotein B component via a disulfide bond. Circulating levels of Lp(a) are mainly genetically determined. Lp(a) has many functions, which include proatherosclerotic, prothrombotic, a...
Source: Annals of Medicine - May 28, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Clinical Practice Patterns in Revascularization of Diabetic Patients with Coronary Heart Disease: Nationwide Register Study.
Authors: Lehto HR, Pietilä A, Niiranen TJ, Lommi J, Salomaa V Abstract Aims: To compare diabetic patients with coronary heart disease (CHD) needing revascularization to corresponding non-diabetic patients in terms of revascularization methods, comorbidities and urgency of procedure. We also examined the impact of patient characteristics and comorbidities on the revascularization method.Methods: We identified all diabetic (n = 33,018) and non-diabetic (n = 106,224) patients with first-ever, percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) from electr...
Source: Annals of Medicine - May 21, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Role of Sodium Glucose Co-Transporter 2 Inhibitors in Patients with Heart Failure: An Elusive Mechanism.
Authors: Imran H, Nestor W, Elgendy IY, Saad M Abstract Heart failure (HF) is a major cause of morbidity and mortality worldwide, and the burden of HF continues to rise. There has been an interest in sodium-glucose co-transporter-2 (SGLT2) inhibitors for their role in reducing HF hospitalizations in pivotal trials. Since their approval by the Food and Drug Administration for the management of diabetes mellitus, multiple small trials and analyses have tried to explain the underlying beneficial mechanisms in HF across different subgroups. In this review, we discuss different mechanisms by which SGLT2 inhibitors play ...
Source: Annals of Medicine - May 14, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Multi-Tiered Screening and Diagnosis Strategy for COVID-19: A Model for Sustainable Testing Capacity in Response to Pandemic.
Authors: Pulia MS, O'Brien TP, Hou PC, Schuman A, Sambursky R Abstract Coronavirus disease 2019 (COVID-19), caused by novel enveloped single stranded RNA coronavirus (SARS-CoV-2), is responsible for an ongoing global pandemic. While other countries deployed widespread testing as an early mitigation strategy, the U.S. experienced delays in development and deployment of organism identification assays. As such, there is uncertainty surrounding disease burden and community spread, severely hampering containment efforts. COVID-19 illuminates the need for a tiered diagnostic approach to rapidly identify clinically signif...
Source: Annals of Medicine - May 8, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Prognostic value of myocardial injury-related findings onresting electrocardiography for cardiovascular risk in the asymptomatic general population: The 12-year follow-up report from the Ansan-Ansung cohort.
Authors: Shin J, Lee Y, Park JK, Shin JH, Lim YH, Ran H, Kim HJ, Park HC Abstract Background: We investigated the predictive values of myocardial injury-related findings (MIFs)including ST-T wave abnormalities (STA) and pathologic Q waves (PQ) in electrocardiography for long-term cardiovascular outcomes in an asymptomatic general population.Methods: We observed8,444 subjects without cardiovascular diseases and related symptoms biennially over a 12-year period. Major cardiovascular adverse events (MACEs) weredefined as a composite of cardiovascular death, myocardial infarction, coronary artery disease and stroke.Res...
Source: Annals of Medicine - April 28, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Clinical significance of increased PML-RARa transcripts after induction therapy for acute promyelocytic leukaemia.
Conclusions: Our studies showed the increased PML-RARa transcripts after induction treatment had different clinical significance from the decreased PML-RARa transcripts. PMID: 32323584 [PubMed - as supplied by publisher] (Source: Annals of Medicine)
Source: Annals of Medicine - April 24, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research