Point prevalence and clinical profile of patients with delirium admitted in internal medicine department at tertiary care centre in eastern Nepal: a descriptive cross-sectional study
CONCLUSIONS: This study provides critical insights into delirium prevalence and profiles in Eastern Nepal. Identified risk factors underscore the importance of routine screenings and targeted interventions for at-risk populations. Study limitations, including sample size and single-centre focus, call for further research to validate findings and enhance our understanding of delirium's management across diverse healthcare settings. Overall, the study informs clinical practices and prompts broader exploration of delirium in healthcare contexts.PMID:38463110 | PMC:PMC10923295 | DOI:10.1097/MS9.0000000000001761 (Source: Annals of Medicine)
Source: Annals of Medicine - March 11, 2024 Category: Internal Medicine Authors: Tek Nath Yogi Sujan Puri Bhupendra Shah Suraj Nepal Akshat Mishra Source Type: research
The prevalence of fibromyalgia in adults at Al-Karak Jordan: a cross-sectional study
CONCLUSION: This study sheds light on fibromyalgia's prevalence and associated factors in the Al-Karak population. The identified predictors highlight the necessity for comprehensive healthcare strategies and interventions to mitigate the disease burden. These findings aid policymakers and healthcare professionals in planning and implementing effective measures for fibromyalgia management and prevention. Further research is warranted to deepen our understanding of fibromyalgia's complexity and its implications in this region.PMID:38463111 | PMC:PMC10923264 | DOI:10.1097/MS9.0000000000001722 (Source: Annals of Medicine)
Source: Annals of Medicine - March 11, 2024 Category: Internal Medicine Authors: Alaa Akel Mohammed Y Sarhan Majed Al Dwairy Belal Al-Zu'bi Ala Al-Qudah Omar A Alsmarat Taif Alsaraireh Mohammad Abu-Jeyyab Source Type: research
Synthetic biology approach revealed enhancement in haeme oxygenase-1 gene expression by codon pair optimization while reduction by codon deoptimization
Ann Med Surg (Lond). 2024 Jan 11;86(3):1359-1369. doi: 10.1097/MS9.0000000000001465. eCollection 2024 Mar.ABSTRACTHaem oxygenase-1 (HO-1) is a ubiquitously expressed gene involved in cellular homoeostasis, and its imbalance in expression results in various disorders. To alleviate such disorders, HO-1 gene expression needs to be modulated. Codon usage bias results from evolutionary forces acting on any nucleotide sequence and determines the gene expression. Like codon usage bias, codon pair bias also exists, playing a role in gene expression. In the present study, HO-1 gene was recoded by manipulating codon and codon pair b...
Source: Annals of Medicine - March 11, 2024 Category: Internal Medicine Authors: Rekha Khandia Megha Katare Pandey Azmat Ali Khan Igor Baklanov Amer M Alanazi Prakash Nepali Pankaj Gurjar Om Prakash Choudhary Source Type: research
A rare delayed onset of esophageal varices and portal vein thrombosis in a ten-year-old patient following umbilical vein catheterization
CONCLUSION: This case highlights pediatric PVT, emphasizing the need for a collaborative approach among gastroenterologists, hematologists, and geneticists. Further research is required to understand PVT mechanisms and long-term implications, aiding in diagnosis and management, especially when it appears in late childhood. Evaluation is crucial in deciphering thrombophilia-related complications in the context of hypertension.PMID:38463113 | PMC:PMC10923273 | DOI:10.1097/MS9.0000000000001588 (Source: Annals of Medicine)
Source: Annals of Medicine - March 11, 2024 Category: Internal Medicine Authors: Qusay Abdoh Abdalaziz Darwish Mohammad Alnees Mahdi Awwad Duha Najajra Mai Alsadi Maysa Alawneh Source Type: research
Efficacy of metamizole to prevent kidney injury after renal-ischaemic reperfusion injury in Wistar rats
CONCLUSION: Metamizole 100 mg/kgBW can reduce IL-18 and MPO levels in RIRI, giving more optimal results without affecting NGAL levels. Metamizole administration can reduce cumulative EGTI scores in RIRI, both at doses of 100 mg/kgBW and 200 mg/kgBW. This study shows that Metamizole can be used to prevent kidney injury caused by RIRI. IL-18 and MPO can be biomarkers in predicting kidney injury in RIRI.PMID:38463114 | PMC:PMC10923394 | DOI:10.1097/MS9.0000000000001694 (Source: Annals of Medicine)
Source: Annals of Medicine - March 11, 2024 Category: Internal Medicine Authors: Dhirajaya Dharma Kadar Syah Mirsya Warli Kiking Ritarwan Muhammad Ichwan Jufriady Ismi Erjan Fikri Juliandi Harahap Ibnu Alferraly Source Type: research
