Hereditary spherocytosis in a young female in Eastern Nepal: a case report
CONCLUSION: HS remains underdiagnosed, especially in our regions. The osmotic fragility test emerges as an economical diagnostic tool in resource-limited settings, particularly when spherocytosis is absent in the peripheral blood smears. Its inclusion in diagnostic protocols can expedite accurate HS identification and enhance patient outcomes.PMID:38463107 | PMC:PMC10923321 | DOI:10.1097/MS9.0000000000001804 (Source: Annals of Medicine)
Source: Annals of Medicine - March 11, 2024 Category: Internal Medicine Authors: Anusha Rayamajhi Manisha Shrestha Priyanka K C Robin Maskey Source Type: research
Cardiovascular risk assessment in inflammatory bowel disease with coronary calcium score
Ann Med Surg (Lond). 2024 Jan 4;86(3):1496-1505. doi: 10.1097/MS9.0000000000001652. eCollection 2024 Mar.ABSTRACTThe interplay between inflammatory bowel disease (IBD) and atherosclerotic cardiovascular disease (ASCVD) underscores the intricate connections between chronic inflammation and cardiovascular health. This review explores the multifaceted relationship between these conditions, highlighting the emerging significance of the coronary calcium score as a pivotal tool in risk assessment and management. Chronic inflammation, a hallmark of IBD, has far-reaching systemic effects that extend to the cardiovascular system. S...
Source: Annals of Medicine - March 11, 2024 Category: Internal Medicine Authors: Waqar Arif Rasool Chaudhry Muhammad Ashfaq Parvinder Kaur Mahendra Kumar Maria Faraz Jahanzeb Malik Amin Mehmoodi Source Type: research
Japanese encephlu emergence in Australia: the potential population at risk
Ann Med Surg (Lond). 2024 Jan 22;86(3):1540-1549. doi: 10.1097/MS9.0000000000001739. eCollection 2024 Mar.ABSTRACTJapanese encephalitis virus (JEV), an RNA virus transmitted by Culex mosquitoes, primarily cycles between aquatic birds and mosquitoes with pigs as amplifying hosts, posing a significant global encephalitis threat. The emergence and spread of the JEV in new epidemiological regions, such as recent cases in Australia and nonendemic areas like Pune, India, raise significant concerns. With an estimated 68 000 clinical cases and 13 600 to 20 400 deaths annually, JEV poses a substantial global health threat. The viru...
Source: Annals of Medicine - March 11, 2024 Category: Internal Medicine Authors: Afsheen Khan Rumaisa Riaz Abdullah Nadeem Ayesha Amir Tasmiyah Siddiqui Um E A Batool Nahid Raufi Source Type: research
Point prevalence and clinical profile of patients with delirium admitted in internal medicine department at tertiary care centre in eastern Nepal: a descriptive cross-sectional study
CONCLUSIONS: This study provides critical insights into delirium prevalence and profiles in Eastern Nepal. Identified risk factors underscore the importance of routine screenings and targeted interventions for at-risk populations. Study limitations, including sample size and single-centre focus, call for further research to validate findings and enhance our understanding of delirium's management across diverse healthcare settings. Overall, the study informs clinical practices and prompts broader exploration of delirium in healthcare contexts.PMID:38463110 | PMC:PMC10923295 | DOI:10.1097/MS9.0000000000001761 (Source: Annals of Medicine)
Source: Annals of Medicine - March 11, 2024 Category: Internal Medicine Authors: Tek Nath Yogi Sujan Puri Bhupendra Shah Suraj Nepal Akshat Mishra Source Type: research
The prevalence of fibromyalgia in adults at Al-Karak Jordan: a cross-sectional study
CONCLUSION: This study sheds light on fibromyalgia's prevalence and associated factors in the Al-Karak population. The identified predictors highlight the necessity for comprehensive healthcare strategies and interventions to mitigate the disease burden. These findings aid policymakers and healthcare professionals in planning and implementing effective measures for fibromyalgia management and prevention. Further research is warranted to deepen our understanding of fibromyalgia's complexity and its implications in this region.PMID:38463111 | PMC:PMC10923264 | DOI:10.1097/MS9.0000000000001722 (Source: Annals of Medicine)
Source: Annals of Medicine - March 11, 2024 Category: Internal Medicine Authors: Alaa Akel Mohammed Y Sarhan Majed Al Dwairy Belal Al-Zu'bi Ala Al-Qudah Omar A Alsmarat Taif Alsaraireh Mohammad Abu-Jeyyab Source Type: research
Synthetic biology approach revealed enhancement in haeme oxygenase-1 gene expression by codon pair optimization while reduction by codon deoptimization
Ann Med Surg (Lond). 2024 Jan 11;86(3):1359-1369. doi: 10.1097/MS9.0000000000001465. eCollection 2024 Mar.ABSTRACTHaem oxygenase-1 (HO-1) is a ubiquitously expressed gene involved in cellular homoeostasis, and its imbalance in expression results in various disorders. To alleviate such disorders, HO-1 gene expression needs to be modulated. Codon usage bias results from evolutionary forces acting on any nucleotide sequence and determines the gene expression. Like codon usage bias, codon pair bias also exists, playing a role in gene expression. In the present study, HO-1 gene was recoded by manipulating codon and codon pair b...
Source: Annals of Medicine - March 11, 2024 Category: Internal Medicine Authors: Rekha Khandia Megha Katare Pandey Azmat Ali Khan Igor Baklanov Amer M Alanazi Prakash Nepali Pankaj Gurjar Om Prakash Choudhary Source Type: research
A rare delayed onset of esophageal varices and portal vein thrombosis in a ten-year-old patient following umbilical vein catheterization
CONCLUSION: This case highlights pediatric PVT, emphasizing the need for a collaborative approach among gastroenterologists, hematologists, and geneticists. Further research is required to understand PVT mechanisms and long-term implications, aiding in diagnosis and management, especially when it appears in late childhood. Evaluation is crucial in deciphering thrombophilia-related complications in the context of hypertension.PMID:38463113 | PMC:PMC10923273 | DOI:10.1097/MS9.0000000000001588 (Source: Annals of Medicine)
Source: Annals of Medicine - March 11, 2024 Category: Internal Medicine Authors: Qusay Abdoh Abdalaziz Darwish Mohammad Alnees Mahdi Awwad Duha Najajra Mai Alsadi Maysa Alawneh Source Type: research
Efficacy of metamizole to prevent kidney injury after renal-ischaemic reperfusion injury in Wistar rats
CONCLUSION: Metamizole 100 mg/kgBW can reduce IL-18 and MPO levels in RIRI, giving more optimal results without affecting NGAL levels. Metamizole administration can reduce cumulative EGTI scores in RIRI, both at doses of 100 mg/kgBW and 200 mg/kgBW. This study shows that Metamizole can be used to prevent kidney injury caused by RIRI. IL-18 and MPO can be biomarkers in predicting kidney injury in RIRI.PMID:38463114 | PMC:PMC10923394 | DOI:10.1097/MS9.0000000000001694 (Source: Annals of Medicine)
Source: Annals of Medicine - March 11, 2024 Category: Internal Medicine Authors: Dhirajaya Dharma Kadar Syah Mirsya Warli Kiking Ritarwan Muhammad Ichwan Jufriady Ismi Erjan Fikri Juliandi Harahap Ibnu Alferraly Source Type: research
Role and application of CRISPR-Cas9 in the management of Alzheimer's disease
Ann Med Surg (Lond). 2024 Jan 5;86(3):1517-1521. doi: 10.1097/MS9.0000000000001692. eCollection 2024 Mar.ABSTRACTAlzheimer's disease (AD) is a serious health issue that has a significant social and economic impact worldwide. One of the key aetiological signs of the disease is a gradual reduction in cognitive function and irreversible neuronal death. According to a 2019 global report, more than 5.8 million people in the United States (USA) alone have received an AD diagnosis, with 45% of those people falling into the 75-84 years age range. According to the predictions, there will be 15 million affected people in the USA by ...
Source: Annals of Medicine - March 11, 2024 Category: Internal Medicine Authors: Nilay Soni Indrani Kar Jadav Dhruvkumar Narendrasinh Sanjay Kumar Shah Lohini Konathala Nadine Mohamed Meet Popatbhai Kachhadia Mitul Hareshkumar Chaudhary Vyapti A Dave Lakshya Kumar Leeda Ahmadi Varshitha Golla Source Type: research
Examining the psychometric characteristics of the metacognition questionnaire in teaching: a cross-sectional study
CONCLUSION: As a result, it can be stated that the questionnaire has the proper psychometric properties for use in Iranian society and can be used as a valid tool for identifying teachers with teaching problems and teaching methods.PMID:38463116 | PMC:PMC10923395 | DOI:10.1097/MS9.0000000000001813 (Source: Annals of Medicine)
Source: Annals of Medicine - March 11, 2024 Category: Internal Medicine Authors: Ali Rezaeisharif Mehdi Ghorbani Mahdi Naeim Shima Imannezhad Source Type: research
The effect of the four pharmacological pillars of heart failure on haemoglobin level
In this study, we aimed to review the pathophysiology of anaemia in patients with HF and present the current evidence regarding the relationship between the main recommended medications for these patients and haemoglobin levels. The authors conducted a comprehensive search in the medical literature for relevant original clinical articles in which the four pharmacological pillars of HF were given to the patients; we, then, assessed whether the association of use of these medications and haemoglobin level or development of anaemia was provided. These common medications have been shown in the literature that may exacerbate or...
Source: Annals of Medicine - March 11, 2024 Category: Internal Medicine Authors: Darshan Hullon Erfan Taherifard Taif Haitham Al-Saraireh Source Type: research
Catastrophic skin necrosis after total knee arthroplasty: a case report and review of the literature
CONCLUSION: A balance must be achieved between the ability to expose the knee through a prior incision and avoiding extensive undermining of the subcutaneous flaps in patients with previous knee surgery. It may be a better approach to ignore medial incisions and use the classic midline incision.PMID:38463118 | PMC:PMC10923309 | DOI:10.1097/MS9.0000000000001085 (Source: Annals of Medicine)
Source: Annals of Medicine - March 11, 2024 Category: Internal Medicine Authors: Amir Human Hoveidaei Hamidreza Zafari Peyman Mirghaderi Ehsan Ghadimi Sm Javad Mortazavi Source Type: research
Evaluation of variations of optic nerve course in relation to posterior paranasal sinuses in MDCT in a tertiary care center of Nepal: a retrospective cross-section study
CONCLUSION: An understanding of the relationship between optic nerves and posterior PNS, as well as awareness of optic nerve dehiscence, is essential in preventing injuries during sinus surgeries. Type 1 optic nerve predominates among Nepalese patients visiting our hospital.PMID:38463119 | PMC:PMC10923376 | DOI:10.1097/MS9.0000000000001697 (Source: Annals of Medicine)
Source: Annals of Medicine - March 11, 2024 Category: Internal Medicine Authors: Prajwal Dahal Sabina Parajuli Prajina Pradhan Santosh Maharjan Govinda Adhikari Ongden Y Tamang Rudra P Upadhyaya Kapil Dawadi Ashish Shrestha Source Type: research
Is cranioplasty the optimal treatment for contralateral subdural effusion after decompressive craniectomy?: a case report
CONCLUSION: Cranioplasty is one of the curative and optimal method to treat symptomatic CSDE patients, early cranioplasty combined with burr-hole drainage should be performed for conservative treatment failed and intractable cases.PMID:38463120 | PMC:PMC10923307 | DOI:10.1097/MS9.0000000000001789 (Source: Annals of Medicine)
Source: Annals of Medicine - March 11, 2024 Category: Internal Medicine Authors: Qing Ouyang Yongxiang Yang Jingmin Cheng Bing Sun Yuan Ma Source Type: research
Immediate impacts of COVID-19 vaccination on glycemic control in type 1 diabetes mellitus: a systematic review and meta-analysis
CONCLUSION: COVID-19 vaccination has an excellent safety profile in T1DM patients owing to its minimal impacts on immediate glycemic control.PMID:38463121 | PMC:PMC10923380 | DOI:10.1097/MS9.0000000000001752 (Source: Annals of Medicine)
Source: Annals of Medicine - March 11, 2024 Category: Internal Medicine Authors: Pratik Lamichhane Hussain Khalid Cijoy Kanatte Siviyachan Summiya Zafar Mahesh Prasanth Kapil Khanal Anushka Agrawal Loveleen Kaur Jhajj Source Type: research
