Characterization of tongue coating microbiome from patients with colorectal cancer
CONCLUSION: These results elucidate the use of tongue coating microbiome in CRC patients firstly, and the fur-types observed contribute to a better understanding of the microbial community in human. Furthermore, the tongue coating microbiota-based biomarkers provide a valuable reference for CRC prediction and diagnosis.PMID:38686186 | PMC:PMC11057396 | DOI:10.1080/20002297.2024.2344278 (Source: Journal of Oral Microbiology)
Source: Journal of Oral Microbiology - April 30, 2024 Category: Microbiology Authors: Qubo Chen Xiaoting Huang Haiyan Zhang Xuanting Jiang Xuan Zeng Wanhua Li Hairong Su Ying Chen Fengye Lin Man Li Xiangyu Gu Huihui Jin Ruohan Wang Dechang Diao Wei Wang Jin Li Sufen Wei Weizheng Zhang Wofeng Liu Zhiping Huang Yusheng Deng Wen Luo Zuofeng L Source Type: research
Activation of M2 macrophage autophagy by rapamycin increases the radiosensitivity of colorectal cancer xenografts
CONCLUSIONS: Therefore, autophagy-activated M2 supernatant can downregulate the expression of the antiapoptotic genes Livin and Survivin in CRC xenografts, improving the radiosensitivity of CRC by inducing apoptosis in combination with radiotherapy and inhibiting the growth of transplanted tumors.PMID:38687942 | DOI:10.4103/jcrt.jcrt_215_23 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Lening Shao Yongyou Wu Jianping Cao Fengyun Zhong Xiaodong Yang Chungen Xing Source Type: research
Estimated impact and value of blood-based colorectal cancer screening at varied adherence compared with stool-based screening
Conclusions: Triennial screening with mt-sDNA resulted in better clinical outcomes at a lower cost compared with the modeled blood-based test even at perfect adherence, supporting application of blood-based tests only as a secondary screening option.PMID:38686394 | DOI:10.1080/13696998.2024.2349467 (Source: Journal of Medical Economics)
Source: Journal of Medical Economics - April 30, 2024 Category: Health Management Authors: John B Kisiel A Mark Fendrick Derek W Ebner A Burak Ozbay Vahab Vahdat Chris Estes Paul J Limburg Source Type: research
The modulation of autophagy and unfolded protein response by ent-kaurenoid derivative CPUK02 in human colorectal cancer cells
CONCLUSIONS: The study findings suggest CPUK02 may exert its cytotoxic effects by inhibiting UPR and autophagy flux in colorectal cancer cells.PMID:38689181 | DOI:10.1007/s11033-024-09541-2 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 30, 2024 Category: Molecular Biology Authors: Sedigheh Rezayi Morvarid Siri Nasim Rahmani-Kukia Mozhdeh Zamani Sanaz Dastghaib Pooneh Mokarram Source Type: research
The modulation of autophagy and unfolded protein response by ent-kaurenoid derivative CPUK02 in human colorectal cancer cells
CONCLUSIONS: The study findings suggest CPUK02 may exert its cytotoxic effects by inhibiting UPR and autophagy flux in colorectal cancer cells.PMID:38689181 | DOI:10.1007/s11033-024-09541-2 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 30, 2024 Category: Molecular Biology Authors: Sedigheh Rezayi Morvarid Siri Nasim Rahmani-Kukia Mozhdeh Zamani Sanaz Dastghaib Pooneh Mokarram Source Type: research
Synthesis and cytotoxicity of novel 6,8,9-Trisubstituted purine analogs against liver cancer cells
Bioorg Med Chem Lett. 2024 Apr 28:129775. doi: 10.1016/j.bmcl.2024.129775. Online ahead of print.ABSTRACTA series of novel 6-(substituted phenyl piperazine)-8-(4-substituted phenyl)-9-cyclopentyl purines, 10-51, were synthesized by a four-step synthesis, achieving an overall yield of about 43 %. The reaction conditions were effectively optimized, and the final products were obtained with high purity and yield in all synthesis steps. The synthesized nucleobases were evaluated for their in vitro cytotoxic activities on selected human cancer cell lines (HUH7 (liver), HCT116 (colon), and MCF7 (breast)) using the Sulforhodamine...
Source: Bioorganic and Medicinal Chemistry Letters - April 30, 2024 Category: Chemistry Authors: M Fatih Polat Irem Durmaz Şahin P ınar Kul Rengul Cetin Atalay Meral Tuncbilek Source Type: research
Clinical Phenotype and Disease Course of Inflammatory Bowel Disease in Iran: Results of the Iranian Registry of Crohn's and Colitis (IRCC)
CONCLUSION: In this national registry-based study, there are significant differences in some clinical phenotypes such as the prevalence of extra-intestinal manifestations and treatment strategies such as biological use in different geographical locations.PMID:38685844 | DOI:10.34172/aim.2024.27 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - April 30, 2024 Category: Middle East Health Authors: Bahar Saberzadeh-Ardestani Amir Ali Khosravi Fariborz Mansour-Ghanaei Homayoon Vahedi Nadieh Baniasadi Mohammadreza Seyyedmajidi Baran Parhizkar Ahmad Hormati Sayed Jalalledin Naghshbandi Somaieh Matin Amir Abbas Hassan Zadeh Tarang Taghvaei Mohsen Bahram Source Type: research
Colorectal Cancer Incidence in Iran Based on Sex, Age, and Geographical Regions: A Study of 2014-2017 and Projected Rates to 2025
CONCLUSION: The anticipated increase in CRC incidence in Iran emphasizes the need for additional studies to better identify risk factors. Furthermore, implementing screening programs is recommended for individuals at a higher risk of CRC, including men, the elderly population, and those residing in regions with a notable prevalence of CRC.PMID:38685843 | DOI:10.34172/aim.2024.26 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - April 30, 2024 Category: Middle East Health Authors: Hani AziziKia Azin Teymourzadeh Hosein Kouchaki Amin Nakhostin-Ansari Pooya Jafari Doudaran Izadmehr Ahmadinejad Armin Hoveidaei Gholamreza Roshandel Source Type: research
AXL receptor as an emerging molecular target in colorectal cancer
Drug Discov Today. 2024 Apr 27:104005. doi: 10.1016/j.drudis.2024.104005. Online ahead of print.ABSTRACTAXL receptor tyrosine kinase (AXL) is a receptor tyrosine kinase whose aberrant expression has recently been associated with colorectal cancer (CRC), contributing to tumor growth, epithelial-mesenchymal transition (EMT), increased invasiveness, metastatic spreading, and the development of drug resistance. In this review we summarize preclinical data, the majority of which are limited to recent years, convincingly linking the AXL receptor to CRC. These findings support the value of targeting AXL with molecules in drug dis...
Source: Drug Discovery Today - April 30, 2024 Category: Drugs & Pharmacology Authors: Lucia De Rosa Rossella Di Stasi Virginia Fusco Luca D D'Andrea Source Type: research
Erratum: Predicting Functional Recovery and Quality of Life in Older Patients Undergoing Colorectal Cancer Surgery: Real-World Data From the International GOSAFE Study
J Clin Oncol. 2024 Apr 30:JCO2400763. doi: 10.1200/JCO.24.00763. Online ahead of print.NO ABSTRACTPMID:38687952 | DOI:10.1200/JCO.24.00763 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 30, 2024 Category: Cancer & Oncology Source Type: research
Activation of M2 macrophage autophagy by rapamycin increases the radiosensitivity of colorectal cancer xenografts
CONCLUSIONS: Therefore, autophagy-activated M2 supernatant can downregulate the expression of the antiapoptotic genes Livin and Survivin in CRC xenografts, improving the radiosensitivity of CRC by inducing apoptosis in combination with radiotherapy and inhibiting the growth of transplanted tumors.PMID:38687942 | DOI:10.4103/jcrt.jcrt_215_23 (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Lening Shao Yongyou Wu Jianping Cao Fengyun Zhong Xiaodong Yang Chungen Xing Source Type: research
Implementation of Health IT for Cancer Screening in US Primary Care: Scoping Review
CONCLUSIONS: There are substantial evidence gaps regarding the effectiveness of HIT-based interventions, especially those targeting guideline-concordant breast and colorectal cancer screening in primary care. Even less is known about how to enhance the adoption of technologies that have been proven effective in supporting breast, colorectal, or cervical cancer screening. Research is needed to ensure that the potential benefits of effective HIT-based interventions equitably reach diverse primary care populations.PMID:38687595 | DOI:10.2196/49002 (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Constance Owens-Jasey Jinying Chen Ran Xu Heather Angier Amy G Huebschmann Mayuko Ito Fukunaga Krisda H Chaiyachati Katharine A Rendle Kim Robien Lisa DiMartino Daniel J Amante Jamie M Faro Maura M Kepper Alex T Ramsey Eric Bressman Rachel Gold Source Type: research
Determinants of early-onset colorectal cancer: a multicenter case-control study in Iran
CONCLUSION: Early-onset CRC was related to the intake of vegetables, vitamin D and red meat in Iran. Early-onset rectum cancer was associated with regular opium use. Family history was associated with early CRC and early rectum cancer, particularly below the age of 35.PMID:38687254 | DOI:10.1097/CEJ.0000000000000888 (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Giulia Collatuzzo Monireh Sadat Seyyedsalehi Hamideh Rashidian Maryam Hadji Roya Safari-Faramani Abbas Rezaianzadeh Reza Malekzadeh Kazem Zendehdel Paolo Boffetta Source Type: research
Encapsulation of copper phenanthroline within horse spleen apoferritin: characterisation, cytotoxic activity and ability to retain temozolomide
RSC Adv. 2024 Apr 29;14(20):14008-14016. doi: 10.1039/d3ra07430g. eCollection 2024 Apr 25.ABSTRACTProtein capsules are promising drug delivery vehicles for cancer research therapies. Apoferritin (AFt) is a self-assembling 12 nm diameter hollow nanocage with many desirable features for drug delivery, however, control of drug retention inside the protein cage remains challenging. Here we report the encapsulation of copper(ii)-1,10-phenanthroline (Cu(phen)) within the horse spleen AFt (HSAFt) nanocage, by diffusion of the metal through the pores between the protein subunits. Transmission electron microscopy revealed the forma...
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Maria Letizia Cassioli Michael Fay Lyudmila Turyanska Tracey D Bradshaw Neil R Thomas Anca Pordea Source Type: research
Characterization of tongue coating microbiome from patients with colorectal cancer
CONCLUSION: These results elucidate the use of tongue coating microbiome in CRC patients firstly, and the fur-types observed contribute to a better understanding of the microbial community in human. Furthermore, the tongue coating microbiota-based biomarkers provide a valuable reference for CRC prediction and diagnosis.PMID:38686186 | PMC:PMC11057396 | DOI:10.1080/20002297.2024.2344278 (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Qubo Chen Xiaoting Huang Haiyan Zhang Xuanting Jiang Xuan Zeng Wanhua Li Hairong Su Ying Chen Fengye Lin Man Li Xiangyu Gu Huihui Jin Ruohan Wang Dechang Diao Wei Wang Jin Li Sufen Wei Weizheng Zhang Wofeng Liu Zhiping Huang Yusheng Deng Wen Luo Zuofeng L Source Type: research
