Circulating levels of hypoxia-inducible factor-1 α and miR-210 are associated with photosensitivity in systemic lupus erythematosus patients
Conclusion: The dysregulation of circulating miR-210/ HIF-1α levels in SLE/photosensitivity‎ patients is controlled by the presence of additional pathological complications and supposed that hypoxia pathway might interact positively with the pathogenesis and illness progress of SLE.PMID:35034594 | DOI:10.2174/1566524022666220114145220 (Source: Cancer Control)
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Amira M Gamal-Eldeen Cinderella A Fahmy Bassem M Raafat Fayez Althobaiti Iman H Bassyouni Roba M Talaat Source Type: research

Non-pharmacological interventions to reduce pain in dementia: A quasi-experimental study
This study evaluated a non-pharmacological intervention nursing protocol for pain control and assessment of its evolution in a cohort of patients with moderate-to-severe dementia residing in three long-term care facilities in a metropolitan area in Spain. The study was a quasi-experimental pre- and post-exploratory intervention. The presence of pain was evaluated before and after the interventions of nursing protocol for 7 days, carried out by nurses. 157 residents of three centers participated (mean age 81.8 years, 58.1% were women, 83.2% had severe or moderately severe dementia and 65.2%) had regularly scheduled analgesi...
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Julia Gonz ález-Vaca Misericordia Garc ía Hernández Carmen Sarabia Cobo Eva M Melendo Azuela Avelina Tortosa I Moreno Source Type: research

Radiation therapy in borderline resectable pancreatic cancer: A review
CONCLUSION: Once considered a staple of therapy, the role of radiation therapy in borderline resectable pancreatic cancer is evolving as systemic therapy regimens continues to improve. Increased clinical understanding of disease phenotype and response are needed to accurately tailor therapy for individual patients and to improve outcomes in this complex patient population.PMID:35034793 | DOI:10.1016/j.surg.2021.12.013 (Source: Cancer Control)
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Kevin M Turner Aaron M Delman Jordan R Kharofa Milton T Smith Kyuran A Choe Olugbenga Olowokure Gregory C Wilson Sameer H Patel Davendra Sohal Syed A Ahmad Source Type: research

Patient volume and clinical outcome after pancreatic cancer resection: A contemporary systematic review and meta-analysis
Surgery. 2022 Jan 13:S0039-6060(21)01177-6. doi: 10.1016/j.surg.2021.11.029. Online ahead of print.ABSTRACTBACKGROUND: Pancreatic cancer remains a highly fatal disease with a 5-year overall survival of less than 10%. In seeking to improve clinical outcomes, there is ongoing debate about the weight that should be given to patient volume in centralization models. The aim of this systematic review is to examine the relationship between patient volume and clinical outcome after pancreatic resection for cancer in the contemporary literature.METHODS: The Google Scholar, PubMed, and Cochrane Library databases were systematically ...
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Bathiya Ratnayake Sayali A Pendharkar Saxon Connor Jonathan Koea Diana Sarfati Elizabeth Dennett Sanjay Pandanaboyana John A Windsor Source Type: research

Role of Reactivating Mutant p53 Protein in Suppressing Growth and Metastasis of Triple-Negative Breast Cancer
Onco Targets Ther. 2022 Jan 8;15:23-30. doi: 10.2147/OTT.S342292. eCollection 2022.ABSTRACTTumor suppressor p53 protein (p53) plays a vital role throughout the body to conserve DNA stability and prevent cancer. Normally, wild-type p53 protein (wtp53) is either degraded or bound to a negative regulator and is inactive. When damage to DNA occurs within a cell, p53 protein is induced and causes cell cycle arrest. This gives cells a chance to repair, but if damage is too severe, cells undergo apoptosis and are rejected. Mutations in the p53 gene (mtp53) are associated with a variety of cancers and occur in 70-80% of cases of t...
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Taylor P Berke Simon H Slight Salman M Hyder Source Type: research

Hypermethylation Effects of Yiqihuoxue Decoction in Diabetic Atherosclerosis Using Genome-Wide DNA Methylation Analyses
J Inflamm Res. 2022 Jan 8;15:163-176. doi: 10.2147/JIR.S335374. eCollection 2022.ABSTRACTPURPOSE: To investigate if a traditional Chinese medicine formulation, called "Yiqihuoxue" (YQHX), could improve diabetic atherosclerosis (DA) and explore potential mechanisms based on DNA methylation.METHODS: Apolipoprotein E-knockout mice were administered streptozotocin (50 mg/d, i.p.) for 5 days and fed a high-fat diet for 16 weeks. Mice were divided randomly into DA model, rosiglitazone, as well as low-, medium-, and high-dose YQHX groups. Ten healthy C57BL/6J mice were the control group. Serum levels of fasting insulin,...
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Qing-Bing Zhou Yao Chen Yan Zhang Dan-Dan Li Hong-Qin Wang Zi-Jun Jia Yu Jin Feng-Qin Xu Ying Zhang Source Type: research

Secondhand Smoke Exposure in Lao People's Democratic Republic: Results From the 2015 National Adult Tobacco Survey
Conclusion: SHS exposure at home and workplace in Lao PDR is among the highest in South-East Asia. Comprehensive smoke-free policies at government-owned workplaces and facilities, stricter enforcement of these smoke-free policies, and strategies to encourage smoke-free environments at homes and in public places are urgently needed.PMID:35035350 | PMC:PMC8758564 | DOI:10.3389/ijph.2021.1604436 (Source: Cancer Control)
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Shweta Vishwas Kulkarni Phonepadith Xangsayarath Daovieng Douangvichith Latsamy Siengsounthone Khatthanaphone Phandouangsy Ly Thi-Hai Tran Phuc Hong Le Thanh Cong Bui Source Type: research

Clinical efficacy evaluation of Erlotinib Combined with Concurrent Chemoradiotherapy in the treatment of locally advanced Pancreatic Cancer
CONCLUSION: Erlotinib combined with concurrent chemoradiotherapy has been preliminarily proved to be safe and effective in the treatment of locally advanced pancreatic cancer, which can improve the physical condition of patients to a certain extent without significantly increasing adverse reactions.PMID:35035411 | PMC:PMC8713205 | DOI:10.12669/pjms.38.1.4150 (Source: Cancer Control)
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Ci Liu Haobin Yu Yue-Hong Hou Zhen-Lin Gao Ya-Jing Zhang Source Type: research

Expressions of IGF-1R and Ki-67 in breast cancer patients with diabetes mellitus and an analysis of biological characteristics
Pak J Med Sci. 2022 Jan-Feb;38(1):281-286. doi: 10.12669/pjms.38.1.4718.ABSTRACTOBJECTIVES: There is a cross-link of insulin and insulin-like growth factor-1 (IGF-1) with each other's receptors. The present study was carried out to explore the relationship of Type-2 diabetes mellitus (T2DM) with the occurrence and development of breast cancer by analyzing the expression of IGF-1R and Ki-67, as well as the biological characteristics in breast cancer patients with and without diabetes mellitus.METHODS: A total of 102 cases of breast cancer patients with T2DM admitted in Hebei General Hospital from January 2019 to December 20...
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Xiaolu Yan Zhe Gao Ye Zhou Fei Gao Qingxia Li Source Type: research

Effects of Integrated Chinese Traditional Medicine and Conventional Western Medicine on the Quality of Life of Breast Cancer Patients: A Systematic Review and Meta-Analysis
Evid Based Complement Alternat Med. 2022 Jan 7;2022:3123878. doi: 10.1155/2022/3123878. eCollection 2022.ABSTRACTBACKGROUND: Traditional Chinese medicine has been widely used, in conjunction with conventional Western medicine, in clinical practice around the world to treat breast cancer. The study systematically reviewed and summarized the quality of life of breast cancer patients treated with integrated treatment method vs. conventional Western medicine.METHODS: Eight databases including PubMed, EMBASE, Web of Science, the Cochrane Library, Chinese National Knowledge Infrastructure, China Biology Medicine Disc, Chinese Sc...
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Xue Bai Na Ta Guo-Hua Gong Bin Zhang Cheng-Xi Wei Source Type: research

The Clinical Efficacy of Chemotherapy Combined with Traditional Chinese Medicine in the Treatment of Cervical Cancer and Its Influence on Cellular Immunity, Serum CEA, and TNF-alpha
CONCLUSION: Chemotherapy combined with traditional Chinese can help improve the clinical efficacy and immunity in patients with cervical cancer. Moreover, the safety and feasibility of the treatment method are relatively high.PMID:35035510 | PMC:PMC8759920 | DOI:10.1155/2022/7728739 (Source: Cancer Control)
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Qiannan Zhao Juanjuan Liu Sai Wang Xiuqin Wang Xiufang Jiang Source Type: research

Biostatistics of VHL-Gene Transfection in the Health Informatics Analysis of Renal Cell Carcinoma
CONCLUSION: VHL gene expression can significantly inhibit the proliferation ability of renal cancer cell line 786-0 and promote its apoptosis. VHL gene is a potential target for gene therapy of kidney cancer.PMID:35035522 | PMC:PMC8759873 | DOI:10.1155/2022/5297580 (Source: Cancer Control)
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Yunxiang Gong Degang Wang Wengang Wang Source Type: research

Identifying Differentially Expressed tRNA-Derived Small Fragments as a Biomarker for the Progression and Metastasis of Colorectal Cancer
Dis Markers. 2022 Jan 6;2022:2646173. doi: 10.1155/2022/2646173. eCollection 2022.ABSTRACTOBJECTIVES: The epithelial-to-mesenchymal transition (EMT) is one key step for the invasion and metastasis of colorectal cancer (CRC). Up until now, the underlying mechanism of EMT in CRC is still unpromising. Thus, it is essential to have a better understanding of its carcinogenesis. The transfer RNA-derived small fragments (tsRNAs) are a new group of small noncoding RNAs (sncRNAs), including tRNA-derived stress-induced RNAs (tiRNAs) and tRNA-derived fragments (tRFs), which have been observed to play an important role in many cancers...
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Hui Chen Zhiying Xu Hua Cai Ya Peng Li Yang Zhen Wang Source Type: research

Evidence of High-Risk Human Papillomavirus in Esophageal Cancer in East Azerbaijan Province, Northwest of Iran
CONCLUSION: The prevalence of HPV in esophageal cancer can vary depending on the geographical location and other factors. Based on the findings of this study, HPV infection may possibly have contributed to an increased risk of esophageal cancer in a group of patients in Tabriz.PMID:35035645 | PMC:PMC8759902 | DOI:10.1155/2022/1099477 (Source: Cancer Control)
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Zahra Sadeghian Hossein Bannazadeh Baghi Vahdat Poortahmasebi Javid Sadeghi Alka Hasani Arezoo Azadi Mahin Ahangar Oskouee Source Type: research

Oxymatrine inhibits proliferation and apoptosis of human breast cancer cells through the regulation of miRNA-140-5P
Am J Transl Res. 2021 Dec 15;13(12):13674-13682. eCollection 2021.ABSTRACTOBJECTIVE: Oxymatrine has shown strong anti-cancer ability, but its mechanism is not well-studied.METHODS: The inhibitory rates of oxymatrine with various concentrations (0, 1, 2, 4, 6, 8, 16, 32 mg/ml) on MCF-7 cells were detected by CCK-8. The effects of oxymatrine on the expression of miRNA-140-5P in MCF-7 cells were detected by real-time fluorescent quantitative PCR (RT-PCR). miRNA-140-5P mimics or NC mimics were transfected into cells using Lipofectamine 2000. Eventually, the cells were divided into control-group, drug-group, miRNA-140-5P mimics...
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Xu Xiao Xiaolei Hou Wenda Shi Chanchan Hu Yanan Cui Jiuli Hu Zongfang Piao Xiaoqin Zhu Qingshan Li Fan Xu Source Type: research

Effect of comfort nursing on postoperative quality of life, negative emotions and nursing satisfaction in patients undergoing laparoscopic surgery
CONCLUSION: For patients undergoing laparoscopic surgery, comfort nursing can relieve their negative emotions, improve their quality of life and nursing satisfaction, reduce postoperative pain, and thus promote postoperative rehabilitation. Hence, it is worthy of clinical promotion.PMID:35035722 | PMC:PMC8748076 (Source: Cancer Control)
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Yuan Gao Jing Huang Yan Zheng Jiacen Han Source Type: research

Effects of radical cystectomy combined with GC chemotherapy in the treatment of invasive bladder cancer and its influence on the incidence of adverse reactions
Am J Transl Res. 2021 Dec 15;13(12):13845-13853. eCollection 2021.ABSTRACTOBJECTIVE: To explore the efficiency of radical cystectomy combined with GC chemotherapy in the treatment of invasive bladder cancer and its influence on the incidence of adverse reactions.METHODS: The clinical data of 120 patients with invasive bladder cancer admitted to our hospital from February 2015 to February 2016 were retrospectively analyzed. According to different treatment methods, they were equally divided into two groups. The experimental group (n=60) was treated with radical cystectomy combined with GC chemotherapy. The control group (n=...
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Dewen Ban Wei Lu Zheng Lu Bin Li Naichun Zhou Source Type: research

Application of vincristine and cisplatin combined with intensity-modulated radiation therapy in the treatment of patients with advanced cervical cancer
Am J Transl Res. 2021 Dec 15;13(12):13894-13901. eCollection 2021.ABSTRACTOBJECTIVE: To investigate the effect of vincristine and cisplatin combined with intensity-modulated radiation therapy (IMRT) on the treatment of patients with advanced cervical cancer and its influence on adverse reactions.METHODS: In this retrospective clinical trial, 90 patients with advanced cervical cancer admitted to our hospital from January 2019 to January 2020 were collected as research subjects and were divided into two groups according to different treatment methods. The control group received IMRT, and the experimental group was treated wi...
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Heling Zhang Ye Zhang Source Type: research

Effect of different doses of apatinib mesylate combined with chemotherapy on advanced oral cancer
Am J Transl Res. 2021 Dec 15;13(12):13902-13908. eCollection 2021.ABSTRACTOBJECTIVE: To investigate the therapeutic effect and safety of different doses of apatinib mesylate combined with chemotherapy in the treatment of advanced oral cancer.METHODS: Totally 100 patients with advanced oral cancer admitted to our hospital from January 2019 to July 2020 were retrospectively analyzed and divided into a control group (500 mg apatinib mesylate combined with chemotherapy) and an experimental group (250 mg apatinib mesylate combined with chemotherapy). The two groups were compared in terms of the incidence of adverse reactions, t...
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Wei Yan Jiaxuan Yan Yong Chen Qiang Li Yanjun Guo Source Type: research

CalliSpheres() microspheres drug-eluting bead transhepatic artery chemoembolization with or without sorafenib for the treatment of large liver cancer: a multi-center retrospective study
CONCLUSION: DEB-TACE combined with sorafenib is safe and well tolerated in the treatment of large liver cancer. It can improve the tumor control rate and prolong the survival time.PMID:35035734 | PMC:PMC8748101 (Source: Cancer Control)
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Song Liu Guangji Yu Qingdong Wang Long Li Ying Liu Ke Du Fei Zhang Bangli Zhao Guangsheng Zhao Source Type: research

Effect of targeted nursing intervention plus psychological counseling on quality of life, negative emotions, and complications in patients with extensively drug-resistant tuberculosis
Am J Transl Res. 2021 Dec 15;13(12):13950-13958. eCollection 2021.ABSTRACTPURPOSE: To evaluate the effects of targeted nursing intervention plus psychological counseling on the life quality, negative emotions, and complications in patients with extensively drug-resistant tuberculosis (XDR-TB).METHODS: In this prospective study, 88 patients with XDR-TB admitted to Hebei Chest Hospital from Jan 2017 to Dec 2020 were enrolled. All patients were grouped according to RANDBETWEEN (1, 2) function in Excel, assigning 1 to the control group (n=41) for every 2 in the research group (n=44). The control group received routine nursing,...
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Yanhua Lu Hongqian Wang Jianfeng Zhu Na Wang Dan Cui Lingdi Li Source Type: research

Laparoscopic radical resection combined with neoadjuvant chemotherapy in treatment of colorectal cancer: clinical efficacy and postoperative complications
Am J Transl Res. 2021 Dec 15;13(12):13974-13980. eCollection 2021.ABSTRACTOBJECTIVE: To explore the clinical efficacy of laparoscopic radical resection combined with neoadjuvant chemotherapy (NACT) in the treatment of colorectal cancer and its influence on postoperative complications.METHODS: The clinical data of 90 patients with colorectal cancer admitted to our hospital from June 2019 to June 2021 were retrospectively analyzed. According to different treatment methods, patients were divided into a control group (laparoscopic radical resection) and a study group (combined NACT before radical resection), with 45 cases in e...
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Shengchao Wei Jie Xi Shuai Cao Tao Li Jiacheng Xu Wei Li Yuhe Bi Source Type: research

Personalized nursing improves physical condition and life quality of patients undergoing interventional therapy for liver cancer
Am J Transl Res. 2021 Dec 15;13(12):14220-14228. eCollection 2021.ABSTRACTInterventional therapy, which can prolong the survival of patients with liver cancer (LC), is an important means to treat the disease. During interventional therapy for LC, it is essential to make a targeted and detailed nursing plan to ameliorate the prognosis. The purpose of this study was to determine the application significance of personalized nursing in patients undergoing interventional therapy for LC. We retrospectively analyzed 136 patients with LC undergoing interventional therapy. Among them, 70 cases receiving personalized nursing were as...
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Hui Wang Yu'e Liu Jing Shen Tian Du Source Type: research

Application value and feasibility analysis of humanistic health management for cancer screening in physical examination
Am J Transl Res. 2021 Dec 15;13(12):14229-14237. eCollection 2021.ABSTRACTOBJECTIVE: To investigate the application value and feasibility of humanistic health management in cancer screening in physical examination.METHODS: A total of 100 carcinoma patients were randomly grouped into the control group and the experimental group, with 50 cases in each group. The patients in the control group received a general physical examination, while those in the experimental group received humanistic health care management model, health education, environmental management, private nursing and emergency management. The two groups were co...
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Lijin Yan Zhiqi Huang Source Type: research

Effects of Out-of-Hospital Continuous Nursing on Postoperative Breast Cancer Patients by Medical Big Data
This study aimed to explore the application value of the intelligent medical communication system based on the Apriori algorithm and cloud follow-up platform in out-of-hospital continuous nursing of breast cancer patients. In this study, the Apriori algorithm is optimized by Amazon Web Services (AWS) and graphics processing unit (GPU) to improve its data mining speed. At the same time, a cloud follow-up platform-based intelligent mobile medical communication system is established, which includes the log-in, my workstation, patient records, follow-up center, satisfaction management, propaganda and education center, SMS plat...
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Peijuan He Bing Zhang Songna Shen Source Type: research

Myricetin: a Multifunctional Flavonol in Biomedicine
Curr Pharmacol Rep. 2022 Jan 10:1-14. doi: 10.1007/s40495-021-00269-2. Online ahead of print.ABSTRACTPURPOSE OF REVEIW: The root cause of many diseases like CVD, cancer, and aging is free radicals which exert their effect by interfering with different metabolic pathways. The sources of free radicals can be exogenous, like UV rays from sunlight, and endogenous due to different metabolic by-products.In our body, there are defense mechanisms present, such as antioxidant enzymes and antioxidant molecules to combat these free radicals, but if there is an overload of these free radicals in our body, the defense system may not be...
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Gopikrishna Agraharam Agnishwar Girigoswami Koyeli Girigoswami Source Type: research

A Novel Autophagy-Related Prognostic Risk Model and a Nomogram for Survival Prediction of Oral Cancer Patients
CONCLUSIONS: The autophagy-related risk model can evaluate OS for ORCA patients independently since it is accurate and stable. Four prognostic ARGs that composed the model can be studied deeply for target treatment.PMID:35036428 | PMC:PMC8758260 | DOI:10.1155/2022/2067540 (Source: Cancer Control)
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Hongjun Fei Xiongming Chen Source Type: research

Gene knock-out chain reaction enables high disruption efficiency of HPV18 E6/E7 genes in cervical cancer cells
Mol Ther Oncolytics. 2021 Dec 18;24:171-179. doi: 10.1016/j.omto.2021.12.011. eCollection 2022 Mar 17.ABSTRACTA genome editing tool targeting the high-risk human papillomavirus (HPV) oncogene is a promising therapeutic strategy to treat HPV-related cervical cancer. To improve gene knockout efficiency, we developed a gene knockout chain reaction (GKCR) method for continually generating mutagenic disruptions and used this method to disrupt the HPV18 E6 and E7 genes. We verified that the GKCR Cas9/guide RNA (gRNA) cassettes could integrated into the targeted loci via homology-independent targeted insertion (HITI). The qPCR re...
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Rui Tian Jiashuo Liu Weiwen Fan Rui Li Zifeng Cui Zhuang Jin Zhaoyue Huang Hongxian Xie Lifang Li Zheying Huang Zheng Hu Ping Zhou Xun Tian Source Type: research

Adenoviral delivery of an immunomodulatory protein to the tumor microenvironment controls tumor growth
Mol Ther Oncolytics. 2021 Dec 6;24:180-193. doi: 10.1016/j.omto.2021.12.004. eCollection 2022 Mar 17.ABSTRACTTargeted modulation of the immune system against tumors can achieve responses in otherwise refractory cancers, which has spurred efforts aimed at optimizing such strategies. To this end, we have previously investigated cancer immunotherapy approaches using recombinant adenovirus vectors, as well as via modulation of the self-ligand receptor SLAMF7. Here, we present a gene transfer-based immunotherapy approach using targeted expression of a SLAMF7-Fc fusion construct directly into tumors at high concentrations via a ...
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Patrick O'Connell Maja K Blake Yuliya Pepelyayeva Sean Hyslop Sarah Godbehere Ariana M Angarita Cristiane Pereira-Hicks Andrea Amalfitano Yasser A Aldhamen Source Type: research

Evaluation of hyaluronic acid gel dissolution with hyaluronidase in an in-vitro prostate cancer model
CONCLUSIONS: A dose response was observed by HAS injection: highest volumes of HAS dissolute most swiftly. Using a ratio of HA:HAS of 1:2 results in a decrease to half of initial volume within 24 h. This is of special interest when used in clinical practice following erroneous positioning, and dissolution is urgently needed.PMID:35036588 | PMC:PMC8749177 | DOI:10.1016/j.ctro.2021.12.009 (Source: Cancer Control)
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Ben G L Vanneste Ludy Lutgens Evert J Van Limbergen Source Type: research

Outer Membrane Vesicles Secreted by < em > Helicobacter pylori < /em > Transmitting Gastric Pathogenic Virulence Factors
In this study, we extracted and characterized H. pylori OMVs of two strains (standard strain NCTC11637 and clinical strain Hp-400) and analyzed the specific content by proteomic technology. We identified more than 400 proteins in H. pylori OMVs. In addition, we investigated the impact of H. pylori OMVs on cellular functions by detecting proteomic changes in GES1 cells. GES1 cells cocultured with increasing concentrations of H. pylori OMVs were subjected to quantitative proteomic analyses using label-free methods for relative quantitation. The results showed that a total of 4261 proteins were verified, 153 of which were sig...
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Sisi Wei Xiaoya Li Jingjing Wang Yaojie Wang Cong Zhang Suli Dai Xian Wang Xiaoqing Deng Lianmei Zhao Baoen Shan Source Type: research

In Silico and In Vitro Studies for Benzimidazole Anthelmintics Repurposing as VEGFR-2 Antagonists: Novel Mebendazole-Loaded Mixed Micelles with Enhanced Dissolution and Anticancer Activity
ACS Omega. 2021 Dec 22;7(1):875-899. doi: 10.1021/acsomega.1c05519. eCollection 2022 Jan 11.ABSTRACTCancer is a leading cause of death worldwide and its incidence is unfortunately anticipated to rise in the next years. On the other hand, vascular endothelial growth factor receptor 2 (VEGFR-2) is highly expressed in tumor-associated endothelial cells, where it affects tumor-promoting angiogenesis. Therefore, VEGFR-2 is considered one of the most promising therapeutic targets for cancer treatment. Furthermore, some FDA-approved benzimidazole anthelmintics have already shown potential anticancer activities. Therefore, repurpo...
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Ayman Abo Elmaaty Khaled M Darwish Amani Chrouda Amira A Boseila Mohamed A Tantawy Sameh S Elhady Afzal B Shaik Muhamad Mustafa Ahmed A Al-Karmalawy Source Type: research

Differential DNA Methylation by Hispanic Ethnicity Among Firefighters in the United States
Epigenet Insights. 2021 Mar 26;14:25168657211006159. doi: 10.1177/25168657211006159. eCollection 2021.ABSTRACTFirefighters are exposed to a variety of environmental hazards and are at increased risk for multiple cancers. There is evidence that risks differ by ethnicity, yet the biological or environmental differences underlying these differences are not known. DNA methylation is one type of epigenetic regulation that is altered in cancers. In this pilot study, we profiled DNA methylation with the Infinium MethylationEPIC in blood leukocytes from 31 Hispanic white and 163 non-Hispanic white firefighters. We compared DNA met...
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Jaclyn M Goodrich Melissa A Furlong Alberto J Caban-Martinez Alesia M Jung Ken Batai Timothy Jenkins Shawn Beitel Sally Littau John Gulotta Darin Wallentine Jeff Hughes Charles Popp Miriam M Calkins Jefferey L Burgess Source Type: research

Cancer in Patients Referred Abroad For Health Care and Related Foreign Currency Expenses
CONCLUSION: There is a good number of cancer patients among patients referred abroad for health care. The estimated costs incurred by patients referred abroad for cancer care are far greater than funds needed to setup modern cancer care centres in Burundi.PMID:35036843 | PMC:PMC8751540 | DOI:10.24248/eahrj.v5i2.668 (Source: Cancer Control)
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Ruben Niyonsaba Ast ère Manirakiza Laurent Irakoze Source Type: research

Evidence for an Inherited Contribution to Sepsis Susceptibility Among a Cohort of U.S. Veterans
Crit Care Explor. 2022 Jan 11;4(1):e0603. doi: 10.1097/CCE.0000000000000603. eCollection 2022 Jan.ABSTRACTAnalyze a unique clinical and genealogical resource for evidence of familial clustering of sepsis to test for an inherited contribution to sepsis predisposition.DESIGN: Observational study.SETTING: Veteran's Health Affairs (VHA) Genealogy/Phenotype resource, a U.S. genealogy database with veterans individually linked to VHA electronic health records.PATIENTS: Sepsis was identified using International Classification of Disease, 9th Edition and 10th Edition codes. There were two comparison groups: one composed of the all...
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Jordan A Kempker Greg S Martin Matthew T Rondina Lisa A Cannon-Albright Source Type: research

Pre-treatment serum protein levels predict survival of non-small cell lung cancer patients without durable clinical benefit by PD-1/L1 inhibitors
In conclusion, serum levels of CRP and follistatin before ICI initiation, not at the time of PD, are predictive for OS in NDBs, suggesting long-term survivor in NDBs are predetermined by the immune status before ICI initiation.PMID:35037070 | DOI:10.1007/s00262-022-03141-4 (Source: Cancer Control)
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Yuhei Harutani Yuichi Ozawa Eriko Murakami Koichi Sato Jun Oyanagi Hiroaki Akamatsu Takanori Yoshikawa Ryota Shibaki Takeya Sugimoto Katsuyuki Furuta Shunsuke Teraoka Nahomi Tokudome Atsushi Hayata Hiroki Ueda Masanori Nakanishi Yasuhiro Koh Nobuyuki Yama Source Type: research

Prostate radiotherapy and the risk of secondary rectal cancer-a meta-analysis
CONCLUSION: These findings confirm that prostate radiotherapy significantly increases the risk of subsequent rectal cancer. This risk has implications for treatment selection, surveillance and patient counselling. However, it is crucial that this information is presented in a rational and comprehensible manner that does not disproportionately frighten or deter patients from what might be their most suitable treatment modality.PMID:35037077 | DOI:10.1007/s00384-021-04075-6 (Source: Cancer Control)
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Timothy S Nugent Ernest Z Low Matthew R Fahy Noel E Donlon Paul H McCormick Brian J Mehigan Moya Cunningham Charles Gillham Dara O Kavanagh Michael E Kelly John O Larkin Source Type: research

The estrogen receptor beta agonist liquiritigenin enhances the inhibitory effects of the cholesterol biosynthesis inhibitor RO 48-8071 on hormone-dependent breast-cancer growth
CONCLUSION: The ERβ ligand LQ significantly enhanced the inhibition of breast-cancer cell viability and tumor-xenograft growth by RO. The anti-tumor properties of RO may in part be due to an off-target effect that reduces ERα and increases ERβ, the latter of which can then interact with LQ to promote anti-proliferative effects. The RO + LQ combination may have value when considering novel treatment strategies for hormone-dependent breast cancer.PMID:35037188 | DOI:10.1007/s10549-021-06487-y (Source: Cancer Control)
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Yayun Liang Cynthia Besch-Williford Salman M Hyder Source Type: research

Advancing Patient-Centered Cancer Survivorship Care: Evaluation of a Dissemination Project
J Cancer Educ. 2022 Jan 17. doi: 10.1007/s13187-022-02138-y. Online ahead of print.ABSTRACTCare coordination among primary care providers and oncologists continues to be a challenge in cancer survivorship care. The Advancing Patient-Centered Cancer Survivorship Care Toolkit ("Toolkit") was developed to provide a "workshop in a box" for comprehensive cancer control (CCC) stakeholders to advance patient-centered cancer survivorship care in their region. The Toolkit was disseminated through an e-learning module, established webpages, an online forum, and social media. Toolkit dissemination was evaluated us...
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Sylvia Shirima Ruta Brazinskaite Maureen Killackey Beth I Sieloff Cindy Cisneros Mandi L Pratt-Chapman Source Type: research

Quantifying the absolute number of cancer deaths that would be avoided if cancers were diagnosed prior to progressing to distant metastasis, New South Wales, Australia 1985-2014
This study measures the impact of diagnosing cancers early before they metastasise on reducing the burden of cancer death. A cohort of 716,501 people aged 15-89 years diagnosed with a solid cancer in New South Wales, Australia, during 1985-2014 were followed-up to December 2015. Crude probabilities of cancer death by stage at diagnosis were calculated for all solid cancers combined and five individual cancers using flexible parametric relative survival models. These probabilities were used to estimate the number of avoided cancer deaths within 10 years of diagnosis in three 10-year diagnostic periods if all cases with know...
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Xue Qin Yu Paramita Dasgupta Peter Baade Source Type: research

Models for Predicting Early Death in Patients With Stage IV Esophageal Cancer: A Surveillance, Epidemiology, and End Results-Based Cohort Study
CONCLUSIONS: More than 40% of stage IV EC patients suffered from an early death. The models could help clinicians discriminate between low and high risks of early death and strategize individually-tailed therapeutic interventions in stage IV EC patients.PMID:35037487 | DOI:10.1177/10732748211072976 (Source: Cancer Control)
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Min Shi Guo-Qing Zhai Source Type: research

FOLFIRINOX versus gemcitabine plus nab-paclitaxel as the first-line chemotherapy in metastatic pancreatic cancer
This study was a retrospective cohort, multi-institution analysis. The focus of the present study was to compare the efficiency of FFX and GNP chemotherapy combinations in the first-line treatment of PCa. Efficacy had been measured by progression-free survival (PFS) and overall survival (OS). 182 patients diagnosed with PCa receiving metastatic first-line treatment were retrospectively analyzed. Patients were divided into two groups one hundred and three (56.6%) patients treated with FFX and seventy-nine (43.4%) patients treated with GNP. Patients in the FFX group were younger and had a better ECOG performance status. Over...
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Seval Ay Muhammed Mustafa Atc ı Rukiye Ar ıkan Özgecan Dülgar Deniz Tataro ğlu Özyükseler Nail Paksoy İzzet Doğan Bu ğra Öztosun Didem Ta ştekin Ba şak Bala Öven Mahmut G ümüş Source Type: research

The association between episodes of night eating and levels of depression in the general population
This study aimed to examine whether having episodes of night eating was associated with increased levels of depression.METHOD: This study used data from the 2019 Korea Community Health Survey and the study population consisted of adults aged ≥19 years. Depression levels were measured using the Patient Health Questionnaire-9. We investigated the patients' general characteristics using t-tests and analysis of variance. The association between depression levels and episodes of night eating was analyzed using a multivariable linear regression analysis. Subgroup analysis was conducted based on daily sleep duration.RESULTS: W...
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Woorim Kim Yeong Jun Ju Soon Young Lee Source Type: research

Necrotizing leg gangrene from invasive cutaneous Kaposi sarcoma, reversed by pegylated liposomal doxorubicin
CONCLUSION: Most patients with Kaposi sarcoma achieve partial responses to treatment with PLD. Our case illustrates that near complete and complete responses are possible with this agent, leading to potential limb salvage in necrotizing gangrene.PMID:35037777 | DOI:10.1177/10781552211073532 (Source: Cancer Control)
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Catherine B Goff Ann Stapleton David M Aboulafia Constantin A Dasanu Source Type: research

Computer-delivered intervention for individuals with obesity and elevated anxiety sensitivity: feasibility, acceptability, and initial test
Cogn Behav Ther. 2022 Jan 17:1-18. doi: 10.1080/16506073.2021.2018487. Online ahead of print.ABSTRACTObesity is one the fastest growing public health problems related to numerous chronic diseases and frequently co-occurs with negative mood states. One promising approach to address the heterogeneity of affective vulnerabilities and obesity is to focus on processes (e.g. anxiety sensitivity [AS]) that underpin both conditions. Thus, this study aimed to evaluate the feasibility, acceptability, and initial efficacy of a brief, computer-delivered AS reduction program (AST) for adults with obesity and elevated AS. Participants w...
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Brooke Y Kauffman Matthew W Gallagher Andres G Viana Norman B Schmidt Michael J Zvolensky Source Type: research

A Web- and Mobile-Based Intervention for Women Treated for Breast Cancer to Manage Chronic Pain and Symptoms Related to Lymphedema: Results of a Randomized Clinical Trial
CONCLUSIONS: The TOLF intervention had significant benefits for breast cancer survivors to manage chronic pain, soreness, general bodily pain, arm/hand swelling, heaviness, and impaired limb mobility. The intervention resulted in a 13% reduction (from 40% [24/60] to 27% [16/60]) in proportions of patients who took pain medications compared with the AP control group, which had a 5% increase (from 40% [24/60] to 45% [27/60]). A 12% reduction (from 27% [16/60] to 15% [9/60]) in proportions of patients with ≥5% limb volume differences was found in the TOLF intervention, while a 5% increase in the AP control group (from 40% ...
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Mei Rosemary Fu Deborah Axelrod Amber A Guth Joan Scagliola Kavita Rampertaap Nardin El-Shammaa Jeanna M Qiu Melissa L McTernan Laura Frye Christopher S Park Gary Yu Charles Tilley Yao Wang Source Type: research

In vivo and in vitro inhibition of SCLC by combining dual cancer-specific recombinant adenovirus with Etoposide
CONCLUSIONS: The above results indicate that when combined with Etoposide, Ad-VT may have an important role in synergistically inhibiting tumors.PMID:35038020 | DOI:10.1007/s00432-021-03899-7 (Source: Cancer Control)
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Tingyu Li Jinbo Fang Jihao Chu Xing Liu Yiquan Li Yilong Zhu Shanzhi Li Zhiru Xiu Yaru Li Ningyi Jin Guangzhe Zhu Lili Sun Xiao Li Source Type: research

mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells
Protein Cell. 2022 Jan 17. doi: 10.1007/s13238-021-00898-9. Online ahead of print.NO ABSTRACTPMID:35038130 | DOI:10.1007/s13238-021-00898-9 (Source: Cancer Control)
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Qun Chu Feifei Liu Yifang He Xiaoyu Jiang Yusheng Cai Zeming Wu Kaowen Yan Lingling Geng Yichen Zhang Huyi Feng Kaixin Zhou Si Wang Weiqi Zhang Guang-Hui Liu Shuai Ma Jing Qu Moshi Song Source Type: research

Analgesia for major laparoscopic abdominal surgery: a randomised feasibility trial using intrathecal morphine
Anaesthesia. 2022 Jan 17. doi: 10.1111/anae.15651. Online ahead of print.ABSTRACTEffective pain control enhances patient recovery after surgery. Laparoscopic techniques for major abdominal surgery are increasingly utilised to reduce surgical trauma. Intrathecal morphine is an attractive analgesic option that is gaining popularity. However, limited evidence guides its use in the setting of laparoscopic surgery. In addition, enhanced recovery after surgery pathways advocate opioid-sparing techniques. We conducted a feasibility trial to compare intrathecal morphine with non-neuraxial analgesia in laparoscopic or laparoscopic-...
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: K Pirie M A Doane B Riedel P S Myles Source Type: research

Isolation and Genomic Analysis of Single Circulating Tumor Cell Using Human Telomerase Reverse Transcriptase and Desmoglein-2
Small Methods. 2022 Jan 17:e2100938. doi: 10.1002/smtd.202100938. Online ahead of print.ABSTRACTAs epithelial cells in the circulation are considered to originate from the tumor, the epithelial cell adhesion molecule has been commonly used as a standard marker for circulating tumor cells (CTCs) isolation. However, it seems to disappear after the epithelial-mesenchymal transition that most cancer cells undergo for intravasation. Thus, more advanced techniques for CTC detection are needed to better understand the clinical significance of CTCs. A cancer cell-specifically-infecting or replicating virus that codes a fluorescent...
Source: Cancer Control - January 17, 2022 Category: Cancer & Oncology Authors: Jae Won Song Jungyo Suh Seok Won Lee Jung Ki Yoo Uijeong Lee Jang Hee Han Cheol Kwak Minyong Kang Yi Rang Kim Chang Wook Jeong Jin Woo Choi Source Type: research