FBXW7 tumor suppressor regulation by dualspecificity tyrosine-regulated kinase 2
Cell Death Dis. 2023 Mar 18;14(3):202. doi: 10.1038/s41419-023-05724-0.ABSTRACTFBXW7 is a member of the F-box protein family, which functions as the substrate recognition component of the SCF E3 ubiquitin ligase. FBXW7 is a main tumor suppressor due to its ability to control proteasome-mediated degradation of several oncoproteins such as c-Jun, c-Myc, Cyclin E1, mTOR, and Notch1-IC. FBXW7 inactivation in human cancers results from a somatic mutation or downregulation of its protein levels. This work describes a novel regulatory mechanism for FBXW7 dependent on the serine/threonine protein kinase DYRK2. We show that DYRK2 i...
Source: Cancer Control - March 19, 2023 Category: Cancer & Oncology Authors: Rafael Jim énez-Izquierdo Rosario Morrugares Luc ía Suanes-Cobos Alejandro Correa-S áez Mart ín Garrido-Rodríguez Laura Cerero-Tejero Omar M Khan Susana de la Luna Roc ío Sancho Marco A Calzado Source Type: research

Multiparameter prediction model of immune checkpoint inhibitors combined with chemotherapy for non-small cell lung cancer based on support vector machine learning
Sci Rep. 2023 Mar 18;13(1):4469. doi: 10.1038/s41598-023-31189-4.ABSTRACTThe reliable predictive markers to identify which patients with advanced non-small cell lung cancer tumors (NSCLC) will achieve durable clinical benefit (DCB) for chemo-immunotherapy are needed. In this retrospective study, we collected radiomics and clinical signatures from 94 patients with advanced NSCLC treated with anti-PD-1/PD-L1 combined with chemotherapy from January 1, 2018 to May 31, 2022. Radiomics variables were extracted from pretreatment CT and selected by Spearman correlation coefficients and clinical features by Logistics regression ana...
Source: Cancer Control - March 19, 2023 Category: Cancer & Oncology Authors: Zihan Zhou Wenjie Guo Dingqi Liu Jose Ramon Nsue Micha Yue Song Shuhua Han Source Type: research

Parent and alkylated polycyclic aromatic hydrocarbon emissions from coal seam fire at Wuda, Inner Mongolia, China: characteristics, spatial distribution, sources, and health risk assessment
Environ Geochem Health. 2023 Mar 18. doi: 10.1007/s10653-023-01476-0. Online ahead of print.ABSTRACTThe Wuda coalfield in Inner Mongolia is a vital coal base in China, and it is the hardest-hit area for coal fires (spontaneous combustion of coal seams and coal gangue). Using gas chromatography-mass spectrometry, this work tested the concentration and analyzed the characteristics, distribution, sources, and health risks of polycyclic aromatic compounds (PACs) in the surface soil of the Wuda District, including the coal mine, coal fire, agricultural, and background areas. The soil of coal mine and coal fire area were heavily...
Source: Cancer Control - March 19, 2023 Category: Cancer & Oncology Authors: Yahui Qian Keyue Yuan Jing Wang Zhenpeng Xu Handong Liang Cai Tie Source Type: research

Role of the human solute carrier family 14 member 1 gene in hypoxia-induced renal cell carcinoma occurrence and its enlightenment to cancer nursing
CONCLUSIONS: These data reveal that nursing based on oxygen administration can improve the clinical efficacy of renal cell carcinoma therapies, being safe and effective. The results elucidate a mechanism wherein the solute carrier family 14 member 1 gene participates in the occurrence and development of hypoxia-induced renal cell carcinoma in a mitochondria-dependent manner.PMID:36934247 | DOI:10.1186/s12860-023-00473-6 (Source: Cancer Control)
Source: Cancer Control - March 19, 2023 Category: Cancer & Oncology Authors: Jing Shi Ruili Sha Xilan Yang Source Type: research

Enhanced immune complex formation in the lungs of patients with dermatomyositis
CONCLUSION: Strong immunoglobulin and C3 expression in the lungs involve lung injury related to dermatomyositis-related interstitial lung disease. Enhanced immune complex formation in the lungs may contribute to the poor prognosis of MDA5 autoantibody-positive dermatomyositis-related interstitial lung disease.PMID:36934274 | PMC:PMC10024827 | DOI:10.1186/s12931-023-02362-0 (Source: Cancer Control)
Source: Cancer Control - March 19, 2023 Category: Cancer & Oncology Authors: Yoshiaki Zaizen Masaki Okamoto Koichi Azuma Junya Fukuoka Hironao Hozumi Noriho Sakamoto Takafumi Suda Hiroshi Mukae Tomoaki Hoshino Source Type: research

Dietary omega-3 fatty acids and endometrial cancer risk in the Epidemiology of Endometrial Cancer Consortium: An individual-participant meta-analysis
CONCLUSION: Higher dietary intakes of LCn3PUFA are unlikely to reduce endometrial cancer incidence; rather, they may be associated with small to moderate increases in risk in some subgroups of women, particularly overweight/obese women.PMID:36934308 | PMC:PMC10025515 | DOI:10.1016/j.ygyno.2022.10.015 (Source: Cancer Control)
Source: Cancer Control - March 19, 2023 Category: Cancer & Oncology Authors: Theodore M Brasky Erinn M Hade David E Cohn Alison M Newton Stacey Petruzella Kelli O'Connell Kimberly A Bertrand Linda S Cook Immaculata De Vivo Mengmeng Du Jo L Freudenheim Christine M Friedenreich Marc T Goodman Jessica Gorzelitz Torukiri I Ibiebele Vi Source Type: research

Chemotherapy-induced peripheral neuropathy in the detroit research on cancer survivors (ROCS) cohort
CONCLUSIONS: CIPN is a common and persistent complication in AA cancer survivors. Further research is needed to improve our understanding of CIPN predictors in all groups of cancer survivors.PMID:36934365 | DOI:10.1007/s10552-023-01676-0 (Source: Cancer Control)
Source: Cancer Control - March 19, 2023 Category: Cancer & Oncology Authors: Kalyan Sreeram Randell Seaton Mark K Greenwald Mandana Kamgar Hadeel Assad Tara Baird Ann G Schwartz Julie Ruterbusch Michael S Simon Source Type: research

Hypothyroidism-associated immunosuppression involves induction of galectin-1-producing regulatory T cells
FASEB J. 2023 Apr;37(4):e22865. doi: 10.1096/fj.202200884R.ABSTRACTHypothyroidism exerts deleterious effects on immunity, but the precise role of the hypothalamic-pituitary-thyroid (HPT) axis in immunoregulatory and tolerogenic programs is barely understood. Here, we investigated the mechanisms underlying hypothyroid-related immunosuppression by examining the regulatory role of components of the HPT axis. We first analyzed lymphocyte activity in mice overexpressing the TRH gene (Tg-Trh). T cells from Tg-Trh showed increased proliferation than wild-type (WT) euthyroid mice in response to polyclonal activation. The release o...
Source: Cancer Control - March 19, 2023 Category: Cancer & Oncology Authors: Eduardo Valli Tom ás Dalotto-Moreno Helena A Sterle Santiago P M éndez-Huergo Mar ía A Paulazo Silvia I Garc ía Carlos J Pirola Alicia J Klecha Gabriel A Rabinovich Graciela A Cremaschi Source Type: research

Prior irinotecan exposure does not preclude benefit to liposomal irinotecan in patients with metastatic pancreatic ductal adenocarcinoma
CONCLUSIONS: Prior irinotecan was not found to be a significant predictor of patient outcomes in those later treated with liposomal irinotecan. Thus, the results may inform the rationale for utilizing liposomal irinotecan combination therapy following prior irinotecan exposure in mPDAC, in particular where the prior irinotecan exposure was more distant in time.PMID:36934451 | DOI:10.1002/cam4.5714 (Source: Cancer Control)
Source: Cancer Control - March 19, 2023 Category: Cancer & Oncology Authors: Kenneth H Yu Paul Cockrum Andy Surinach Neil Lamarre Shu Wang Eileen M O'Reilly Source Type: research

The Cost Analysis of Human Papillomavirus Vaccination Program in Indonesia
CONCLUSIONS: The implementation of demonstration program in Surabaya, Makassar, and Manado cities was considerably succeed. Any prediction related to the cost of implementation of HPV vaccination in Indonesia can be calculated and used to advocate regional or national government.PMID:36934486 | DOI:10.1016/j.vhri.2023.01.005 (Source: Cancer Control)
Source: Cancer Control - March 19, 2023 Category: Cancer & Oncology Authors: Didik Setiawan Andi Nurul Annisa None Lianawati Raymond C W Hutubessy Karene Hoi Ting Yeung Source Type: research

Long non-coding RNA LINC01480 is activated by Foxo3a and promotes hydroquinone-induced TK6 cell apoptosis by inhibiting the PI3K/AKT pathway
In this study, when TK6 cells were treated with HQ (0, 5, 10, and 20 μM) for 12, 24, 48, and 72 h, the expression of LINC01480 was increased in a dose-dependent manner. Meanwhile, the phosphorylation levels of PI3K and AKT decreased, and apoptosis increased. As compared to the control group, HQ-induced apoptosis was significantly reduced, and the relative survival rate of TK6 cells increased after silencing LINC01480, while overexpression of LINC01480 further sensitized TK6 cells to HQ-induced apoptotic cell death. LINC01480 negatively regulated the PI3K/AKT pathway in TK6 cells, and the apoptosis-inhibiting effect of LIN...
Source: Cancer Control - March 19, 2023 Category: Cancer & Oncology Authors: Hui Yang Yuting Chen Minjuan Zeng Haipeng Wu Xiangli Zou Tiantian Fang Lu Zhai Hairong Liang Hao Luo Gaiqin Tian Qizhan Liu Huanwen Tang Source Type: research

A novel role for Mms2 in the control of spontaneous mutagenesis and Pol3 abundance
DNA Repair (Amst). 2023 Mar 13;125:103484. doi: 10.1016/j.dnarep.2023.103484. Online ahead of print.ABSTRACTMms2 is a ubiquitin E2-variant protein with a very well-documented function in the tolerance pathway that protects both human and yeast cells from the lethal and mutagenic effects of DNA damage. Interestingly, a high expression level of human MMS2 is associated with poor survival prognosis in different cancer diseases. Here we have analyzed the physiological effects of Mms2 overproduction in yeast cells. We show that an increased level of this protein causes a spontaneous mutator effect independent of Ubc13, a cognat...
Source: Cancer Control - March 19, 2023 Category: Cancer & Oncology Authors: Michal Krawczyk Agnieszka Halas Ewa Sledziewska-Gojska Source Type: research

Elevated markers of DNA damage and senescence are associated with the progression of albuminuria and restrictive lung disease in patients with type 2 diabetes
This study was conducted to investigate the cascade involving DNA damage, senescence, and senescence-associated secretory phenotype (SASP) in experimental diabetes and in a four-year follow-up study in patients with pre-diabetes and type 2 diabetes.METHODS: Kidney, lung, and liver were studied in 4 months diabetic db/db mice and age-matched controls for the presence of DNA damage and fibrosis. DNA damage (comet-tail-length and ɤH2Ax-positivity in white blood cells), urinary p21-excretion, and plasma IL-6 and TGF-β1 were determined from 115 healthy participants, 34 patients with pre-diabetes and 221 with type 2 diabetes. ...
Source: Cancer Control - March 19, 2023 Category: Cancer & Oncology Authors: Kumar Varun Kender Zoltan Sulaj Alba Blume Manuel Kliemank Elisabeth Tsilingiris Dimitrios Groener Jan B Brune Maik Shahzad Khurrum Isermann Berend Herzig Stephen Fleming Thomas Szendroedi Julia Nawroth Peter Kopf Stefan Source Type: research

Stackelberg evolutionary game theory: how to manage evolving systems
This article is part of the theme issue 'Half a century of evolutionary games: a synthesis of theory, application and future directions'.PMID:36934755 | DOI:10.1098/rstb.2021.0495 (Source: Cancer Control)
Source: Cancer Control - March 19, 2023 Category: Cancer & Oncology Authors: Alexander Stein Monica Salvioli Hasti Garjani Johan Dubbeldam Yannick Viossat Joel S Brown Kate řina Staňková Source Type: research

Comparison of two supporting matrices for patient-derived cancer cells in 3D drug sensitivity and resistance testing assay (3D-DSRT)
This study provides a proof-of-concept for robust and fast screening of drug sensitivities of PDCs in 3D-DSRT, which is important not only for drug discovery but also for personalized ex vivo drug testing in functional precision medicine studies. These findings suggest that comparing results of 2D- and 3D-DSRT is essential for understanding drug mechanisms and for selecting the most effective treatment for the patient.PMID:36934951 | DOI:10.1016/j.slasd.2023.03.002 (Source: Cancer Control)
Source: Cancer Control - March 19, 2023 Category: Cancer & Oncology Authors: Michaela Feodoroff Piia Mikkonen Laura Turunen Antti Hassinen Lauri Paasonen Lassi Paavolainen Swapnil Potdar Astrid Murum ägi Olli Kallioniemi Vilja Pieti äinen Source Type: research