Critical role of neutralizing antibody for SARS-CoV-2 reinfection and transmission.
Abstract Cases of laboratory-confirmed SARS-CoV-2 reinfection have been reported in a number of countries. Further, the level of natural immunity induced by SARS-CoV-2 infection is not fully clear, nor is it clear if a primary infection is protective against reinfection. To investigate the potential association between serum antibody titres and reinfection of SARS-CoV-2, ferrets with different levels of NAb titres after primary SARS-CoV-2 infection were subjected to reinfection with a heterologous SARS-CoV-2 strain. All heterologous SARS-CoV-2 reinfected ferrets showed active virus replication in the upper respira...
Source: Cancer Control - January 27, 2021 Category: Cancer & Oncology Authors: Kim YI, Kim SM, Park SJ, Kim EH, Yu KM, Chang JH, Kim EJ, Casel MAB, Rollon R, Jang SG, Um J, Song MS, Jeong HW, Kim EG, Kim Y, Kim SY, Park JS, Park MS, Kwon GY, Yeo SG, Lee SA, Choi YJ, Jung JU, Choi YK Tags: Emerg Microbes Infect Source Type: research

Novel piperazine-chalcone hybrids and related pyrazoline analogues targeting VEGFR-2 kinase; design, synthesis, molecular docking studies, and anticancer evaluation.
Abstract New piperazine-chalcone hybrids and related pyrazoline derivatives have been designed and synthesised as potential vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors. The National Cancer Institute (NCI) has selected six compounds to evaluate their antiproliferative activity in vitro against 60 human cancer cells lines. Preliminary screening of the examined compounds indicated promising anticancer activity against number of cell lines. The enzyme inhibitory activity against VEGFR-2 was evaluated and IC50 of the tested compounds ranged from 0.57 µM to 1.48 µM. ...
Source: Cancer Control - December 24, 2020 Category: Cancer & Oncology Authors: Ahmed MF, Santali EY, El-Haggar R Tags: J Enzyme Inhib Med Chem Source Type: research

Is there an Ethnic Predisposition to Developing Brain Metastases (BM) in Asian Patients with Colorectal Cancer?
CONCLUSION: Our study showed an incidence of brain metastases of 7% in the Asian sub-population compared to the historical control of 0.6% - 3.2% in the overall population. These results at the least warrant further investigation in a larger patient population of brain metastases in CRC patients with emphasis on molecular markers. PMID: 32577630 [PubMed] (Source: Cancer Control)
Source: Cancer Control - June 26, 2020 Category: Cancer & Oncology Authors: McGovern K, Smith MH, Maloney A, Jose J, Saif MW Tags: Cancer Med J Source Type: research

A high-throughput assay for screening natural products that boost NK cell-mediated killing of cancer cells.
Conclusions: Our newly established ATP-based method was a valuable and information-rich screening tool to investigate the biological effects of natural products on both NK cells and tumour cells. PMID: 32356467 [PubMed - in process] (Source: Cancer Control)
Source: Cancer Control - May 3, 2020 Category: Cancer & Oncology Authors: Xu Z, Zhu X, Su L, Zou C, Chen X, Hou Y, Gong C, Ng W, Ni Z, Wang L, Yan X, Zhu Y, Jiao X, Yao C, Zhu S Tags: Pharm Biol Source Type: research

Curcumin inhibited the growth and invasion of human monocytic leukaemia SHI-1 cells in  vivo by altering MAPK and MMP signalling.
Discussion and conclusions: Our study demonstrates that curcumin can inhibit the growth and invasion of human monocytic leukaemia in vivo, suggesting the possible use of curcumin for anti-metastasis in leukaemia and the value of determining its unique target. PMID: 31854220 [PubMed - in process] (Source: Cancer Control)
Source: Cancer Control - December 20, 2019 Category: Cancer & Oncology Authors: Zhu G, Shen Q, Jiang H, Ji O, Zhu L, Zhang L Tags: Pharm Biol Source Type: research

The Dilemma of TP53 Codon 72 Polymorphism (rs1042522) and Breast Cancer Risk: A Case-Control Study and Meta-Analysis in The Iranian Population.
Conclusion: These findings cannot support contribution of rs1042522 polymorphism to breast cancer risk in an Iranian population. Future larger studies may help confirm this finding with a greater power. PMID: 31721533 [PubMed] (Source: Cancer Control)
Source: Cancer Control - November 15, 2019 Category: Cancer & Oncology Authors: Afzaljavan F, Chaeichi Tehrani N, Rivandi M, Zarif Ghasemian S, Vahednia E, Khayami R, Abavisani M, Pasdar A Tags: Cell J Source Type: research

Phospholipase-C γ1 Signaling Protein Down-Regulation by Oligoclonal-VHHs based Immuno-Liposome: A Potent Metastasis Deterrent in HER2 Positive Breast Cancer Cells.
Conclusion: PLCγ1 protein levels did indeed decrease after treatment with immuno-liposome form of compounds in both two tested cell lines, verifying the inhibition ability of them. Moreover, an elevated antibody activity is associated with liposomes conjugation suggesting that immuno-liposome may be a potential target for enhancing the antibody activity. PMID: 31606964 [PubMed] (Source: Cancer Control)
Source: Cancer Control - October 14, 2019 Category: Cancer & Oncology Authors: Asadpour O, Rahbarizadeh F Tags: Cell J Source Type: research

Aptamer (AS1411)-Conjugated Liposome for Enhanced Therapeutic Efficacy of miRNA-29b in Ovarian Cancer.
Abstract AS1411 Aptamer-functionalized liposome was successfully formulated and found to be nanosized. Flow cytometer and CLSM results demonstrated that Aptamer enhanced the targeting of carrier in the cancer cells via nucleolin-mediated transmembrane endocytosis pathway. The lipofectaminebased miR-29b showed a typical concentration-dependent cytotoxic effect in the cancer cells. LP-miR induced a significant reduction in the cell viability of A2780 cells compared to that of nontreated control, while LP-Mut (mutant loaded) did not have any effect on the cell viability indicating the importance of the specific gene ...
Source: Cancer Control - September 9, 2019 Category: Cancer & Oncology Authors: Jiang L, Wang H, Chen S Tags: J Nanosci Nanotechnol Source Type: research

Biotin-functionalized copolymeric PEG-PCL micelles for in vivo tumour-targeted delivery of artemisinin.
In this study, biotin-conjugated copolymers were fabricated with polymerization of the ring opening method and the properties of copolymer and nanoparticles were investigated using various techniques. The toxicity of artemisinin and its nanoparticles have been investigated on MCF-7 and normal HFF2 cells. The results showed that the encapsulation efficacy of artemisinin in nanoparticles was 45.5 ± 0.41%. The release profile of the drug indicates that the release is slow and controlled and is approximately pH dependent. The results of artemisinin cell culture on human breast cancer cells showed that biotin-PEG-PCL nan...
Source: Cancer Control - January 23, 2019 Category: Cancer & Oncology Authors: Nosrati H, Barzegari P, Danafar H, Kheiri Manjili H Tags: Artif Cells Nanomed Biotechnol Source Type: research

Endoscopic repair of the urinary bladder with magnetically labeled mesenchymal stem cells: Preliminary report.
Conclusions: The magnetic delivery of MSCs shows promise as an effective, minimally invasive method of enhancing tissue regeneration after TURBT. PMID: 30581896 [PubMed] (Source: Cancer Control)
Source: Cancer Control - December 27, 2018 Category: Cancer & Oncology Authors: Sadahide K, Teishima J, Inoue S, Tamura T, Kamei N, Adachi N, Matsubara A Tags: Regen Ther Source Type: research

Direct notification of cervical cytology results to women improves follow-up in cervical cancer screening - A cluster-randomised trial.
Abstract Up to half of all women do not receive follow-up as recommended after cervical cytology testing and are thus at increased risk of dysplasia progression. Women from lower social positions are at increased risk of not receiving follow-up. Sample takers, often general practitioners, convey results to women, but communication problems constitute a challenge. We aimed to investigate the effect of direct notification of cervical cytology results on follow-up rates. In a 1:1 cluster-randomised controlled trial, we assessed if having the pathology department convey cervical cytology results directly to the invest...
Source: Cancer Control - December 22, 2018 Category: Cancer & Oncology Authors: Kristiansen BK, Andersen B, Bro F, Svanholm H, Vedsted P Tags: Prev Med Rep Source Type: research

Modification of chitosan grafted with collagen peptide by enzyme crosslinking.
Abstract Free radicals are closely related to the occurrence and development of aging, cancer and inflammation. In this paper, the microbial transglutaminase (MTGase) was used as a catalyst to graft the collagen peptide (COP) molecules on the amino group of carboxymethyl chitosan sulfate (CMCS) to improve the antioxidant effects. FT-IR and NMR spectroscopy were used to confirm the successful grafting of COP to CMCS. Degree of substitution (DS) of CMCS-COP could be controlled by adjusting the reaction conditions. With the increase of concentration, the ability of each sample on scavenging capacity and reducibility ...
Source: Cancer Control - December 18, 2018 Category: Cancer & Oncology Authors: Hu W, Liu M, Yang X, Zhang C, Zhou H, Xie W, Fan L, Nie M Tags: Carbohydr Polym Source Type: research

The health risk for seafood consumers under future ocean acidification (OA) scenarios: OA alters bioaccumulation of three pollutants in an edible bivalve species through affecting the in vivo metabolism.
Abstract The current knowledge about the effect of pCO2-driven ocean acidification on the bioaccumulation of pollutants in marine species is still scarce, as only limited types of pollutants have been investigated. Therefore, to obtain a better understanding of the effect of ocean acidification on the process of bioaccumulation and subsequent food safety, the accumulation of benzo[a]pyrene (B[a]P), chloramphenicol (CAP), and nitrofurazone (NFZ) in an edible bivalve species, Tegillarca granosa, under present and near-future ocean acidification scenarios was investigated in the present study. The health risks associ...
Source: Cancer Control - November 1, 2018 Category: Cancer & Oncology Authors: Su W, Shi W, Han Y, Hu Y, Ke A, Wu H, Liu G Tags: Sci Total Environ Source Type: research

Integrating bioassays, chemical analysis and in silico techniques to identify genotoxicants in surface water.
This study highlights the capability of in silico techniques in linking adverse biological effect to suspicious hazardous compounds for the identification of toxicity drivers, and demonstrates the genotoxic potential of pollutants in the Danube. PMID: 30373085 [PubMed - in process] (Source: Cancer Control)
Source: Cancer Control - November 1, 2018 Category: Cancer & Oncology Authors: Shao Y, Hollert H, Tarcai Z, Deutschmann B, Seiler TB Tags: Sci Total Environ Source Type: research

Targeted metabolomics in bladder cancer: From analytical methods development and validation towards application to clinical samples.
Abstract Bladder cancer constitutes the ninth most common cancer worldwide and, despite continuous development of new diagnostic approaches, the thirteenth leading cause of global cancer mortality. In our previous untargeted urine metabolomic investigation, seventeen metabolites were found to be statistically differentiating bladder cancer patients and healthy volunteers. Therefore, the main goal of this study was to develop and validate an analytical method for simultaneous quantitative determination of those metabolites using reversed phase high-performance liquid chromatography coupled with triple quadrupole ma...
Source: Cancer Control - October 9, 2018 Category: Cancer & Oncology Authors: Yumba Mpanga A, Siluk D, Jacyna J, Szerkus O, Wawrzyniak R, Markuszewski M, Matuszewski M, Kaliszan R, Markuszewski MJ Tags: Anal Chim Acta Source Type: research

The relationship between comorbidity medication adherence and health related quality of life among patients with cancer.
Conclusion: The positive association between low comorbidity medication adherence and the number of unhealthy days suggests that addressing barriers to comorbidity medication adherence during cancer treatment may be an avenue for improving or maintaining HRQoL for older patients with cancer and comorbid conditions. PMID: 30294709 [PubMed] (Source: Cancer Control)
Source: Cancer Control - October 9, 2018 Category: Cancer & Oncology Authors: Drzayich Antol D, Waldman Casebeer A, Khoury R, Michael T, Renda A, Hopson S, Parikh A, Stein A, Costantino M, Stemkowski S, Bunce M Tags: J Patient Rep Outcomes Source Type: research

Bioinformatics analysis to identify action targets in NCI-N87 gastric cancer cells exposed to quercetin.
CONCLUSIONS: CYP1A1 highly interconnected with AHR in the PPI network. Therefore, FOS, AHR, JUN, CYP1A1, EGR1, FOSL1, and WNT7B might be targets of quercetin in gastric cancer. PMID: 30266078 [PubMed - in process] (Source: Cancer Control)
Source: Cancer Control - October 1, 2018 Category: Cancer & Oncology Authors: Zeng Y, Shen Z, Gu W, Wu M Tags: Pharm Biol Source Type: research

A systematic review of associations between non-communicable diseases and socioeconomic status within low- and lower-middle-income countries.
Conclusions: Only 17 of the 84 LLMICs were represented, highlighting the need for more research on NCDs within these countries. The majority of studies were medium to high quality cross-sectional studies. When we restricted our analyses to high quality studies only, for both cancer and cardiovascular disease more than half of studies found a significantly higher risk for those of lower SES. The opposite was true for diabetes, whilst there was a paucity of high quality research on chronic respiratory disease. Development programmes must consider health alongside other aims and NCD prevention interventions must target all me...
Source: Cancer Control - August 26, 2018 Category: Cancer & Oncology Authors: Williams J, Allen L, Wickramasinghe K, Mikkelsen B, Roberts N, Townsend N Tags: J Glob Health Source Type: research

Lithium induces mesenchymal-epithelial differentiation during human kidney development by activation of the Wnt signalling system.
In this study, we isolated mesenchymal cell lines derived from human first trimester kidneys in monolayer culture and investigated their differentiation potential. We found that the mesenchymal cells could convert into osteogenic, but not adipogenic or endothelial lineages. Furthermore, addition of lithium chloride led to MET which was accompanied by increases in epithelial (CDH1) and tubular (ENPEP) markers and downregulation of renal progenitor (SIX2, EYA1, CD133) and mesenchymal markers (HGF, CD24). Prior to phenotypic changes, lithium chloride altered Wnt signalling with elevations in AXIN2, GSK3β phosphorylation ...
Source: Cancer Control - March 15, 2018 Category: Cancer & Oncology Authors: Price KL, Kolatsi-Joannou M, Mari C, Long DA, Winyard PJD Tags: Cell Death Discov Source Type: research

Targeted delivery of doxorubicin by CSA-binding nanoparticles for choriocarcinoma treatment.
Abstract Gestational trophoblastic neoplasia (GTN) can result from the over-proliferation of trophoblasts. Treatment of choriocarcinoma, the most aggressive GTN, currently requires high doses of systemic chemotherapeutic agents, which result in indiscriminate drug distribution and severe toxicity. To overcome these disadvantages and enhance the chemotherapeutic efficacy, chondroitin sulfate A (CSA)-binding nanoparticles were developed for the targeted delivery of doxorubicin (DOX) to choriocarcinoma cells using a synthetic CSA-binding peptide (CSA-BP), derived from malarial protein, which specifically binds to the...
Source: Cancer Control - February 12, 2018 Category: Cancer & Oncology Authors: Zhang B, Cheng G, Zheng M, Han J, Wang B, Li M, Chen J, Xiao T, Zhang J, Cai L, Li S, Fan X Tags: Drug Deliv Source Type: research

Community-based physical activity as adjunctive smoking cessation treatment: Rationale, design, and baseline data for the Lifestyle Enhancement Program (LEAP) randomized controlled trial.
We describe the rationale and study design and report baseline participant characteristics from the Lifestyle Enhancement Program (LEAP), a two-group, randomized controlled trial. Adult smokers who engaged in low levels of leisure time physical activity were randomly assigned to treatment conditions consisting of an individualized physical activity intervention delivered by health fitness instructors in community-based exercise facilities or an equal contact wellness control. All participants received standard cognitive behavioral smoking cessation counseling combined with nicotine replacement therapy. The primary outcomes...
Source: Cancer Control - January 17, 2018 Category: Cancer & Oncology Authors: Vander Weg MW, Coday M, Stockton MB, McClanahan B, Relyea G, Read MC, Wilson N, Connelly S, Richey P, Johnson KC, Ward KD Tags: Contemp Clin Trials Commun Source Type: research

Decreased Expression of Arginine-Phenylalanine-Amide-Related Peptide-3 Gene in Dorsomedial Hypothalamic Nucleus of Constant Light Exposure Model of Polycystic Ovarian Syndrome.
Abstract Background: An abnormality in pulse amplitude and frequency of gonadotropin releasing hormone (GnRH) secretion is the most characteristics of polycystic ovarian syndrome (PCOS). On the other hand, arginine-phenylalanine-amide (RFamide)-related peptide-3 (RFRP3) inhibits the secretion of GnRH in mammalian hypothalamus. The current study performed in order to investigate the expression of RFRP3 mRNA in the dorsomedial hypothalamic nucleus (DMH) after the induction of PCOS in a rat model of constant light exposure, and the possible role of parity on occurrence of PCOS. MATERIALS AND METHODS: In the expe...
Source: Cancer Control - January 17, 2018 Category: Cancer & Oncology Authors: Shaaban Z, Jafarzadeh Shirazi MR, Nooranizadeh MH, Tamadon A, Rahmanifar F, Ahmadloo S, Ramezani A, Javad Zamiri M, Razeghian Jahromi I, Sabet Sarvestani F, Koohi Hosseinabadi O Tags: Int J Fertil Steril Source Type: research

Electromagnetic fields and optomechanics in cancer diagnostics and treatment.
Abstract In this paper, we discuss biological effects of electromagnetic (EM) fields in the context of cancer biology. In particular, we review the nanomechanical properties of microtubules (MTs), the latter being one of the most successful targets for cancer therapy. We propose an investigation on the coupling of electromagnetic radiation to mechanical vibrations of MTs as an important basis for biological and medical applications. In our opinion, optomechanical methods can accurately monitor and control the mechanical properties of isolated MTs in a liquid environment. Consequently, studying nanomechanical prop...
Source: Cancer Control - January 4, 2018 Category: Cancer & Oncology Authors: Salari V, Barzanjeh S, Cifra M, Simon C, Scholkmann F, Alirezaei Z, Tuszynski JA Tags: Front Biosci (Landmark Ed) Source Type: research

Effects of the truth FinishIt brand on tobacco outcomes.
Abstract Since 2000, the truth campaign has grown as a social marketing brand. Back then, truth employed branding to compete directly with the tobacco industry. In 2014, the launch of truth FinishIt reflected changes in the brand's strategy, the tobacco control environment, and youth/young adult behavior. Building on a previous validation study, the current study examined brand equity in truth FinishIt, as measured by validated multi-dimensional scales, and tobacco related attitudes, beliefs, and behavior based on two waves of the Truth Longitudinal Cohort data from 2015 and 2016. A fixed effects logistic regressi...
Source: Cancer Control - December 26, 2017 Category: Cancer & Oncology Authors: Evans WD, Rath JM, Hair EC, Snider JW, Pitzer L, Greenberg M, Xiao H, Cantrell J, Vallone D Tags: Prev Med Rep Source Type: research

The impact of lipomatous tumors on type 2 diabetes: are adipose-derived tumors metabolically active?
Abstract BACKGROUND: The metabolic and immunologic properties of adipose tissue are linked to the pathogenesis of type 2 diabetes mellitus. Lipomatous tumors, such as liposarcomas, are rare but can reach significant size. We hypothesized that some lipomatous tumors are metabolically active and can alter systemic glucose homeostasis. METHODS: We performed a retrospective study of patients who underwent resection of a lipomatous tumor at a tertiary cancer referral center (2004-2015). We divided patients into nondiabetics, well-controlled diabetics (hemoglobin A1c [HbA1c] 
Source: Cancer Control - December 25, 2017 Category: Cancer & Oncology Authors: Fallahian F, Ardestani A, Pranckevicius E, Raut CP, Tavakkoli A, Sheu EG Tags: J Surg Res Source Type: research

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.
na-Gomez C, Mudgal P, Ng MCY, Reiner AP, Vedantam S, Willems SM, Winkler TW, Abecasis G, Aben KK, Alam DS, Alharthi SE, Allison M, Amouyel P, Asselbergs FW, Auer PL, Balkau B, Bang LE, Barroso I, Bastarache L, Benn M, Bergmann S, Bielak LF, Blüher M, Boehnke M, Boeing H, Boerwinkle E, Böger CA, Bork-Jensen J, Bots ML, Bottinger EP, Bowden DW, Brandslund I, Breen G, Brilliant MH, Broer L, Brumat M, Burt AA, Butterworth AS, Campbell PT, Cappellani S, Carey DJ, Catamo E, Caulfield MJ, Chambers JC, Chasman DI, Chen YI, Chowdhury R, Christensen C, Chu AY, Cocca M, Collins FS, Cook JP, Corley J, Corominas Galbany J, Co...
Source: Cancer Control - December 25, 2017 Category: Cancer & Oncology Authors: Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, Guo X, Hendricks AE, Karaderi T, Lempradl A, Locke AE, Mahajan A, Marouli E, Sivapalaratnam S, Young KL, Alfred T, Feitosa MF, Masca NGD, Manning AK, Med Tags: Nat Genet Source Type: research

Effects of parenteral ω-3 fatty acid supplementation in postoperative gastrointestinal cancer on immune function and length of hospital stay: a systematic review and meta-analysis.
This study assessed the effects of this form of parenteral nutrition on immune function and clinical outcomes in postoperative gastrointestinal cancer patients. METHODS AND STUDY DESIGN: We searched Medline, Embase, Scopus, and the reference lists of selected studies to identify randomized controlled trials that compared ω-3 fatty acids with a control, and that included immune indices, infectious complications, or length of hospital stay in the final outcomes. The odds ratio and weighted mean difference with 95% confidence intervals were calculated and the I2 statistic was used to assess heterogeneity. RESU...
Source: Cancer Control - December 11, 2017 Category: Cancer & Oncology Authors: Bai H, Li Z, Meng Y, Yu Y, Zhang H, Shen D, Chen L Tags: Asia Pac J Clin Nutr Source Type: research

Analysis of Cotranslational Polyamine Sensing During Decoding of ODC Antizyme mRNA.
ohmen R Abstract Polyamines are essential poly-cations with vital functions in all cellular systems. Their levels are controlled by intricate regulatory feedback mechanisms. Abnormally high levels of polyamines have been linked to cancer. A rate-limiting enzyme in the biosynthesis of polyamines in fungi and higher eukaryotes is ornithine-decarboxylase (ODC). Its levels are largely controlled posttranslationally via ubiquitin-independent degradation mediated by ODC antizyme (OAZ). The latter is a critical polyamine sensor in a feedback control mechanism that adjusts cellular polyamine levels. Here, we describe an a...
Source: Cancer Control - October 30, 2017 Category: Cancer & Oncology Authors: Palanimurugan R, Gödderz D, Kurian L, Jürgen Dohmen R Tags: Methods Mol Biol Source Type: research

Transcriptional regulation of p57(kip2) expression during development, differentiation and disease.
Abstract p57(kip2) is the most complex member of the CIP/KIP family of cyclin-dependent kinase inhibitors and plays a fundamental role in regulating cell cycle and differentiation during mammalian development. Consistently with a key role for p57(kip2) in the spatial and temporal control of cell proliferation, its expression is fine-tuned by multiple regulatory mechanisms, resulting in a tissue-, developmental phase- and cell type-specific pattern. Moreover, p57(kip2) is an imprinted gene, further supporting the importance of its proper expression dosage. Importantly, misregulation of p57(kip2) expression has been...
Source: Cancer Control - September 22, 2017 Category: Cancer & Oncology Authors: Rossi MN, Andresini O, Matteini F, Maione R Tags: Front Biosci (Landmark Ed) Source Type: research

Quantification of MicroRNAs in Urine-Derived Specimens.
Abstract MicroRNAs are small noncoding RNAs which regulate the expression of genes involved in a multitude of cellular processes. Dysregulation of microRNAs and-in consequence-of the affected pathways is frequently observed in numerous pathologies including cancers. Therefore, tumor-related alterations in microRNA expression and function can reflect molecular processes of tumor onset and progression qualifying microRNAs as potential diagnostic and prognostic biomarkers.In particular, microRNAs with differential expression in bladder cancer (BCa) might represent promising tools for noninvasive tumor detection in ur...
Source: Cancer Control - September 12, 2017 Category: Cancer & Oncology Authors: Fuessel S, Lohse-Fischer A, Vu Van D, Salomo K, Erdmann K, Wirth MP Tags: Methods Mol Biol Source Type: research

Nanotechniques Inactivate Cancer Stem Cells.
In this study, the ability of synthesized hybrid nanocomplexes, comprising the nanoparticles of rare earth orthovanadates GdYVO4:Eu(3+) and cholesterol to inhibit the tumor growth and to increase the survival of the animals with tumors was established. A special contribution into tumor-inhibiting effect is made by each of its components. Treatment of Ehrlich carcinoma cells with two-component hybrid complex resulted in maximum reduction in the concentration of the most tumorigenic CD44(high) cells with simultaneous rise in the number of CD117(+) cells that decreased an intensity of tumor growth by 74.70 ±&thi...
Source: Cancer Control - June 18, 2017 Category: Cancer & Oncology Authors: Goltsev AN, Babenko NN, Gaevskaya YA, Bondarovich NA, Dubrava TG, Ostankov MV, Chelombitko OV, Malyukin YV, Klochkov VK, Kavok NS Tags: Nanoscale Res Lett Source Type: research

Rice Bran Metabolome Contains Amino Acids, Vitamins & Cofactors, and Phytochemicals with Medicinal and Nutritional Properties.
CONCLUSION: Rice bran metabolite profiling revealed a suite of biochemical molecules that can be further investigated and exploited for multiple nutritional therapies and medical food applications. These bioactive compounds may also be biomarkers of dietary rice bran intake. The medicinal compounds associated with rice bran can function as a network across metabolic pathways and this metabolite network may occur via additive and synergistic effects between compounds in the food matrix. PMID: 28547736 [PubMed - in process] (Source: Cancer Control)
Source: Cancer Control - May 28, 2017 Category: Cancer & Oncology Authors: Zarei I, Brown DG, Nealon NJ, Ryan EP Tags: Rice (N Y) Source Type: research

Cigarette Filter Ventilation and its Relationship to Increasing Rates of Lung Adenocarcinoma.
Abstract The 2014 Surgeon General's Report on smoking and health concluded that changing cigarette designs have caused an increase in lung adenocarcinomas, implicating cigarette filter ventilation that lowers smoking machine tar yields. The Food and Drug Administration (FDA) now has the authority to regulate cigarette design if doing so would improve public health. To support a potential regulatory action, two weight-of-evidence reviews were applied for causally relating filter ventilation to lung adenocarcinoma. Published scientific literature (3284 citations) and internal tobacco company documents contributed to...
Source: Cancer Control - May 20, 2017 Category: Cancer & Oncology Authors: Song MA, Benowitz NL, Berman M, Brasky TM, Cummings KM, Hatsukami DK, Marian C, O'Connor R, Rees VW, Woroszylo C, Shields PG Tags: J Natl Cancer Inst Source Type: research

Female Breast Cancer Mortality Clusters in Shandong Province, China: A Spatial Analysis.
This study aimed to detect the spatial distribution and high-risk clusters of female breast cancer mortality for the years 2011 to 2013 in Shandong Province, China. The urban-rural difference in the spatial distribution and clusters of disease mortality were also examined. Breast cancer mortality data were obtained from the Shandong Death Registration System (SDRS) during 2011 to 2013 and were adjusted for the underreporting rate. The purely spatial scan Statistics method was performed using Discrete Poisson model. Seven significant spatial clusters for high mortality of female breast cancer were detected in Shandong Provi...
Source: Cancer Control - March 11, 2017 Category: Cancer & Oncology Authors: Chu J, Zhou C, Guo X, Sun J, Xue F, Zhang J, Lu Z, Fu Z, Xu A Tags: Sci Rep Source Type: research

Control of brain metastases with alectinib in anaplastic lymphoma kinase-rearranged lung cancer.
Abstract Brain metastasis from non-small cell lung cancer remains a challenge to physicians. It occurs in 30% of patients with advanced stage adenocarcinoma of lung and is often regarded as the ominous sign of disease progression and death. Alectinib is likely to be a promising agent, even after the failure of crizotinib and ceritinib, for patients with anaplastic lymphoma kinase (ALK) -driven non-small cell lung cancer with brain metastasis, resulting in a durable response for both intracranial and extra-cranial diseases. PMID: 28275428 [PubMed - in process] (Source: Cancer Control)
Source: Cancer Control - March 11, 2017 Category: Cancer & Oncology Authors: Kwok WC, Tam TC, Lui MM, Lam DC, Ho JC Tags: Respirol Case Rep Source Type: research

Cervical cancer screening and treatment in Uganda.
Abstract Cervical cancer is the leading cause of cancer death among women in Uganda. Given the high prevalence of genital human papillomavirus infection, the current unavailability of radiotherapy, and the absence of a national cervical cancer prevention and control program, these deaths will likely increase. Efforts to organize an effective cervical cancer screening and treatment program will require adequate financial resources, the development of infrastructure, training needed manpower, and surveillance mechanisms of the targeted women. Screening with VIA (visual inspection with acetic acid) and HPV DNA testin...
Source: Cancer Control - March 11, 2017 Category: Cancer & Oncology Authors: Nakisige C, Schwartz M, Ndira AO Tags: Gynecol Oncol Rep Source Type: research

SMYD5 regulates H4K20me3-marked heterochromatin to safeguard ES cell self-renewal and prevent spurious differentiation.
CONCLUSIONS: Altogether, these findings implicate a role for SMYD5 in regulating ES cell self-renewal and H4K20me3-marked heterochromatin. PMID: 28250819 [PubMed - in process] (Source: Cancer Control)
Source: Cancer Control - March 3, 2017 Category: Cancer & Oncology Authors: Kidder BL, Hu G, Cui K, Zhao K Tags: Epigenetics Chromatin Source Type: research

Alcoholic Extract of Eclipta alba Shows In Vitro Antioxidant and Anticancer Activity without Exhibiting Toxicological Effects.
Abstract As per WHO estimates, 80% of people around the world use medicinal plants for the cure and prevention of various diseases including cancer owing to their easy availability and cost effectiveness. Eclipta alba has long been used in Ayurveda to treat liver diseases, eye ailments, and hair related disorders. The promising medicinal value of E. alba prompted us to study the antioxidant, nontoxic, and anticancer potential of its alcoholic extract. In the current study, we evaluated the in vitro cytotoxic and antioxidant effect of the alcoholic extract of Eclipta alba (AEEA) in multiple cancer cell lines along ...
Source: Cancer Control - March 3, 2017 Category: Cancer & Oncology Authors: Yadav NK, Arya RK, Dev K, Sharma C, Hossain Z, Meena S, Arya KR, Gayen JR, Datta D, Singh RK Tags: Oxid Med Cell Longev Source Type: research

Assessment of Correlation between Chromosomal Radiosensitivity of Peripheral Blood Lymphocytes after In vitro Irradiation and Normal Tissue Side Effects for Cancer Patients Undergoing Radiotherapy.
This study was conducted to assess the correlation between in vitro radiosensitivity of peripheral blood lymphocytes from cancer patients who are undergoing radiotherapy using the cytokinesis-block micronucleus (CBMN), G2 chromosomal radiosensitivity assays, and normal tissue acute side effects. The CBMN and G2 chromosomal radiosensitivity assays were performed on blood samples taken from cancer patients before radiotherapy, after first fractionation, and after radiotherapy. Acute normal tissue reactions were graded according to the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer...
Source: Cancer Control - March 3, 2017 Category: Cancer & Oncology Authors: Guogytė K, Plieskienė A, Ladygienė R, Vaisiūnas Ž, Sevriukova O, Janušonis V, Žiliukas J Tags: Genome Integr Source Type: research

Retrospective Biological Dosimetry at Low and High Doses of Radiation and Radioiodine Impact on Individual Susceptibility to Ionizing Radiation.
Abstract Iodine-131 (I-131) is often used in thyroid diagnostics and therapy. External and internal exposure to radioiodine can lead to molecular and cellular damage in peripheral blood lymphocytes. The aim of this study was to explore the influence of low and high doses of I-131 on susceptibility to ionizing radiation. Study groups consisted of 30 individuals free of thyroid diseases, 41 patients exposed diagnostically to low doses of I-131, and 37 hyperthyroidism patients exposed therapeutically to high doses. The standardized DNA repair competence assay was used to test the efficacy of the fast DNA repair proce...
Source: Cancer Control - March 3, 2017 Category: Cancer & Oncology Authors: Cebulska-Wasilewska A, Krzysiek M, Krajewska G, Stępień A, Krajewski P Tags: Genome Integr Source Type: research

Fat mass and obesity-associated protein attenuates lipid accumulation in macrophage foam cells and alleviates atherosclerosis in apolipoprotein E-deficient mice.
CONCLUSION: We propose that the FTO-dependent control of cholesterol deposition may provide avenues for the treatment of atherosclerosis. PMID: 28253220 [PubMed - in process] (Source: Cancer Control)
Source: Cancer Control - March 3, 2017 Category: Cancer & Oncology Authors: Mo C, Yang M, Han X, Li J, Gao G, Tai H, Huang N, Xiao H Tags: J Hypertens Source Type: research

Public attitudes toward larger cigarette pack warnings: Results from a nationally representative U.S. sample.
Abstract A large body of evidence supports the effectiveness of larger health warnings on cigarette packages. However, there is limited research examining attitudes toward such warning labels, which has potential implications for implementation of larger warning labels. The purpose of the current study was to examine attitudes toward larger warning sizes on cigarette packages and examine variables associated with more favorable attitudes. In a nationally representative survey of U.S. adults (N = 5,014), participants were randomized to different warning size conditions, assessing attitude toward "a health warn...
Source: Cancer Control - March 3, 2017 Category: Cancer & Oncology Authors: Kowitt SD, Noar SM, Ranney LM, Goldstein AO Tags: PLoS One Source Type: research

SBRT for early-stage glottic larynx cancer-Initial clinical outcomes from a phase I clinical trial.
CONCLUSIONS: We were able to reduce equipotent total fractions of SBRT from 15 to 5 without exceeding protocol-defined acute/subacute toxicity limits. With limited follow-up, disease control appears comparable to standard treatment. We continue to enroll to the 42.5 Gy/5 fx cohort and follow patients for late toxicity. TRIAL REGISTRATION: ClinicalTrials.gov NCT01984502. PMID: 28253270 [PubMed - in process] (Source: Cancer Control)
Source: Cancer Control - March 3, 2017 Category: Cancer & Oncology Authors: Schwartz DL, Sosa A, Chun SG, Ding C, Xie XJ, Nedzi LA, Timmerman RD, Sumer BD Tags: PLoS One Source Type: research

Effects of systemic lidocaine versus magnesium administration on postoperative functional recovery and chronic pain in patients undergoing breast cancer surgery: A prospective, randomized, double-blind, comparative clinical trial.
CONCLUSIONS: Intraoperative infusion of lidocaine improved the quality of recovery and attenuated the intensity of chronic pain in patients undergoing breast cancer surgery. PMID: 28253307 [PubMed - in process] (Source: Cancer Control)
Source: Cancer Control - March 3, 2017 Category: Cancer & Oncology Authors: Kim MH, Lee KY, Park S, Kim SI, Park HS, Yoo YC Tags: PLoS One Source Type: research

Cancer Control; +123 new citations
123 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Cancer Control These pubmed results were generated on 2017/03/02PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Cancer Control)
Source: Cancer Control - March 2, 2017 Category: Cancer & Oncology Tags: Report Source Type: research

Cancer Control; +110 new citations
110 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Cancer Control These pubmed results were generated on 2017/02/28PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Cancer Control)
Source: Cancer Control - March 1, 2017 Category: Cancer & Oncology Tags: Report Source Type: research

Emerging Technologies and Techniques in Radiation Therapy.
Abstract The past decade has brought an improved ability to precisely target and deliver radiation as well as other focal prostate-directed therapy. Stereotactic body radiotherapy (SBRT), proton beam radiation, high-dose-rate (HDR) brachytherapy, as well as nonradiotherapy treatments such as cryoablation and high-intensity focused ultrasound are several therapeutic modalities that have been investigated for the treatment of prostate cancer in an attempt to reduce toxicity while improving cancer control. However, high-risk prostate cancer requires a comprehensive treatment of the prostate as well as areas at risk f...
Source: Cancer Control - December 19, 2016 Category: Cancer & Oncology Authors: Magnuson WJ, Mahal A, Yu JB Tags: Semin Radiat Oncol Source Type: research

Postoperative Radiation After Radical Prostatectomy.
Abstract A total of 3 randomized clinical trials have demonstrated a significant clinical benefit with adjuvant radiation in patients with high-risk prostate cancer after radical prostatectomy, with each showing improved biochemical control outcomes, and one trial (SWOG 8794) also demonstrating increased overall survival. How broadly these results have informed clinical practice has evolved over time, given the widespread availability of ultrasensitive prostate-specific antigen level testing and increased awareness that the high-risk patients are not a uniform cohort. In this review, we discuss the evidence from p...
Source: Cancer Control - December 19, 2016 Category: Cancer & Oncology Authors: Ko EC, Michaud AL, Valicenti RK Tags: Semin Radiat Oncol Source Type: research

Nonsteroidal Anti-inflammatory Drugs and Endometrial Carcinoma Mortality and Recurrence.
CONCLUSIONS: In this study, use of NSAIDs was associated with increased endometrial carcinoma-specific mortality, especially in patients with type I tumors. Barring a clear biologic mechanism by which NSAIDs would increase the risk of cause-specific mortality, cautious interpretation is warranted. PMID: 27986878 [PubMed - in process] (Source: Cancer Control)
Source: Cancer Control - December 19, 2016 Category: Cancer & Oncology Authors: Brasky TM, Felix AS, Cohn DE, McMeekin DS, Mutch DG, Creasman WT, Thaker PH, Walker JL, Moore RG, Lele SB, Guntupalli SR, Downs LS, Nagel CI, Boggess JF, Pearl ML, Ioffe OB, Park KJ, Ali S, Brinton LA Tags: J Natl Cancer Inst Source Type: research

Highly Efficient Training, Refinement, and Validation of a Knowledge-based Planning Quality-Control System for Radiation Therapy Clinical Trials.
Abstract PURPOSE: To demonstrate an efficient method for training and validation of a knowledge-based planning (KBP) system as a radiation therapy clinical trial plan quality-control system. METHODS AND MATERIALS: We analyzed 86 patients with stage IB through IVA cervical cancer treated with intensity modulated radiation therapy at 2 institutions according to the standards of the INTERTECC (International Evaluation of Radiotherapy Technology Effectiveness in Cervical Cancer, National Clinical Trials Network identifier: 01554397) protocol. The protocol used a planning target volume and 2 primary organs at...
Source: Cancer Control - December 18, 2016 Category: Cancer & Oncology Authors: Li N, Carmona R, Sirak I, Kasaova L, Followill D, Michalski J, Bosch W, Straube W, Mell LK, Moore KL Tags: Int J Radiat Oncol Biol Phys Source Type: research