Medical students' knowledge about human papillomavirus (HPV), HPV vaccine and head and neck cancer
Hum Vaccin Immunother. 2024 Dec 31;20(1):2344248. doi: 10.1080/21645515.2024.2344248. Epub 2024 Apr 24.ABSTRACTThe Human Papillomavirus (HPV) is a sexually transmitted infection that significantly affects the population worldwide. HPV preventive methods include vaccination, prophylactics, and education. Different types of cancers associated with HPV usually take years or decades to develop after infections, such as Head and Neck Cancer(HNC). Therefore, HPV prevention can be considered cancer prevention. A sample of medical students in Puerto Rico was evaluated to assess their knowledge about HPV, HPV vaccine, and HNC throu...
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Norangelys Solis-Torres Isardo Braverman-Diaz Luis A Rivera-Morales Jose J Perez-Sanchez Valeria S Perez-Bravo Angel J Neris-Sanchez Alexis Vera Yaritza Diaz-Algorri Source Type: research
Oncolytic adenovirus in treating malignant ascites: a phase II trial and longitudinal single-cell study
Mol Ther. 2024 Apr 23:S1525-0016(24)00252-1. doi: 10.1016/j.ymthe.2024.04.029. Online ahead of print.ABSTRACTMalignant ascites is a common complication resulting from the peritoneal spread of malignancies, and currently lacks effective treatments. We conducted a phase II trial (NCT04771676) to investigate the efficacy and safety of oncolytic adenovirus H101 and virotherapy-induced immune response in 25 patients with malignant ascites. Oncolytic virotherapy achieved an increased median time to repeat paracentesis of 45 days (95% confidence interval 16.5-73.5 days), compared to the preset control value of 13 days. Therapy wa...
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Yalei Zhang Ling Qian Kun Chen Sijia Gu Zhiqiang Meng Jia Wang Ye Li Peng Wang Source Type: research
The efficiency and safety of low-dose apatinib combined with oral vinorelbine in pretreated HER2-negative metastatic breast cancer
CONCLUSION: Low-dose apatinib combined with oral vinorelbine demonstrates potential efficacy and well tolerated for pretreated HER2-negative mBC.PMID:38659376 | DOI:10.1002/cam4.7181 (Source: Cancer Control)
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Jia-Yi Huang Xue-Lian Chen Xiao-Feng Xie Lin Song Li-Ping Chen Xiao-Feng Lan Xue Bai Xiao Chen Cai-Wen Du Source Type: research
Could nutrition status predict fatigue one week before in patients with nasopharynx cancer undergoing radiotherapy?
CONCLUSIONS: The PG-SGA may be a more accurate predictor of future-week fatigue than individual body composition indicators, particularly when HADS is controlled for as a time-dependent confounder.PMID:38659395 | DOI:10.1002/cam4.7191 (Source: Cancer Control)
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Jihong Song Xinru Yang Jieling Wu Zilan Wu Litao Zhuo Jinsheng Hong Li Su Wenlong Lyu Jinru Ye Yan Fang Zhiying Zhan Hairong Zhang Xiaomei Li Source Type: research
Enhanced Uranium Extraction via Charge Dynamics and Interfacial Polarization in MoS < sub > 2 < /sub > /GO Heterojunction Electrodes
Small. 2024 Apr 25:e2401374. doi: 10.1002/smll.202401374. Online ahead of print.ABSTRACTThe removal of uranyl ions (UO2 2+) from water is challenging due to their chemical stability, low concentrations, complex water matrix, and technical limitations in extraction and separation. Herein, a novel molybdenum disulfide/graphene oxide heterojunction (MoS2/GO-H) is developed, serving as an effective electrode for capacitive deionization (CDI). By combining the inherent advantages of electroadsorption and electrocatalysis, an innovative electroadsorption-electrocatalysis system (EES) strategy is introduced. This system utilizes ...
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Yuhui Liu Jiayin Zhao Tao Bo Rongteng Tian Yingcai Wang Sheng Deng Hao Jiang Yunhai Liu Grzegorz Lisak Mengyu Chang Xiaoyan Li Shuang Zhang Source Type: research
Association of leptin receptor polymorphisms with susceptibility of non-small cell lung cancer: Evidence from 2249 subjects
This study highlights that LEPR rs6588147, rs1137101 genotypes and LEPR Ars1037100Ars1037101Ars6588147 haplotype are correlated with the occurrence of NSCLC. LEPR rs1137100 G>A SNP increases the risk of lymph node metastases.PMID:38659416 | DOI:10.1002/cam4.7178 (Source: Cancer Control)
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Weifeng Tang Jian Wang Ting Dai Hao Qiu Chao Liu Shuchen Chen Zhendong Hu Source Type: research
Recent clinical trials and optical control as a potential strategy to develop microtubule-targeting drugs in colorectal cancer management
World J Gastroenterol. 2024 Apr 7;30(13):1780-1790. doi: 10.3748/wjg.v30.i13.1780.ABSTRACTColorectal cancer (CRC) has remained the second and the third leading cause of cancer-related death worldwide and in the United States, respectively. Although significant improvement in overall survival has been achieved, death in adult populations under the age of 55 appears to have increased in the past decades. Although new classes of therapeutic strategies such as immunotherapy have emerged, their application is very limited in CRC so far. Microtubule (MT) inhibitors such as taxanes, are not generally successful in CRC. There may ...
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Katsuhiro Kita Allen Burdowski Source Type: research
A Deeper Depth of Response After Salvage Therapy Improves Outcomes of Autologous Stem Cell Transplantation in Relapsed Lymphoma and the Feasibility of Non-controlled Rate Freezing of Peripheral Blood Stem Cells
Conclusion High-dose therapy and autologous stem cell transplantation in low- to middle-income countries are limited to relatively younger patients, potentially curative conditions such as lymphoma, and predominantly after achieving a complete response to salvage therapy due to limited resources. Due to these factors, our study shows excellent response rates and survival outcomes compared to internationally published data. Engraftment was also excellent and comparable to published data despite the non-controlled rate freezing of peripheral blood stem cells.PMID:38659569 | PMC:PMC11039573 | DOI:10.7759/cureus.56851 (Source: Cancer Control)
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Saif Ur Rab Mussadique Ali Uzma Rasool Mahar Bushra Ahsan Usman Ahmad Muhammad Tariq Mahmood Neelam Siddiqui Syed W Bokhari Source Type: research
Exploring the impact of MiR-92a-3p on FOLFOX chemoresistance biomarker genes in colon cancer cell lines
Conclusion: We found that miR-92a-3p does not upregulate the expression of proteins of DNA-repair pathways and other genes involved in FOLFOX chemotherapy resistance.PMID:38659583 | PMC:PMC11039864 | DOI:10.3389/fphar.2024.1376638 (Source: Cancer Control)
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Paula I Escalante Luis A Qui ñones H éctor R Contreras Source Type: research
Ceramides: a potential cardiovascular biomarker in young adult childhood cancer survivors?
CONCLUSION: Ceramides could be important biomarkers in understanding the pathophysiology of CVD and in predicting CVD disease risk in young adult CCS.PMID:38659666 | PMC:PMC11042783 | DOI:10.1093/ehjopen/oeae026 (Source: Cancer Control)
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Olof Broberg Constance G Weismann Ingrid Øra Thomas Wiebe Reijo Laaksonen Petru Liuba Source Type: research
Gra-CRC-miRTar: The pre-trained nucleotide-to-graph neural networks to identify potential miRNA targets in colorectal cancer
bioRxiv [Preprint]. 2024 Apr 20:2024.04.15.589599. doi: 10.1101/2024.04.15.589599.ABSTRACTColorectal cancer (CRC) is the third most diagnosed cancer and the second deadliest cancer worldwide representing a major public health problem. In recent years, increasing evidence has shown that microRNA (miRNA) can control the expression of targeted human messenger RNA (mRNA) by reducing their abundance or translation, acting as oncogenes or tumor suppressors in various cancers, including CRC. Due to the significant up-regulation of oncogenic miRNAs in CRC, elucidating the underlying mechanism and identifying dysregulated miRNA tar...
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Rui Yin Hongru Zhao Lu Li Qiang Yang Min Zeng Carl Yang Jiang Bian Mingyi Xie Source Type: research
Community Health workers United to Reduce Colorectal cancer and cardiovascular disease among people at Higher risk (CHURCH): study protocol for a randomized controlled trial
Discussion: Church-placed CHWs are trusted influential connectors between communities and health systems. Studies have shown that these CHWs can successfully implement health prevention protocols in churches, including those related to cancer control, making them potentially important community mediators of CRC screening uptake and CRC/CVD risk reduction. Trial registration: NCT05174286.PMID:38659874 | PMC:PMC11042434 | DOI:10.21203/rs.3.rs-3797889/v1 (Source: Cancer Control)
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Olajide Williams Tina Ting Lisa Matthews Gladys Block Torin Block Jeanne Teresi Joseph Eimicke Jian Kong Stephanie Silver Joseph Ravenell Janhavi Mallaiah Soujanya Jammalamadaka Laura Maudene Nelson Wahida Karmally Sidney Hankerson Source Type: research
Gfi1 controls the formation of effector CD8 T cells during chronic infection and cancer
bioRxiv [Preprint]. 2024 Apr 21:2024.04.18.579535. doi: 10.1101/2024.04.18.579535.ABSTRACTDuring chronic infections and tumor progression, CD8 T cells gradually lose their effector functions and become exhausted. These exhausted CD8 T cells are heterogeneous and comprised of different subsets, including self-renewing progenitors that give rise to Ly108 - CX3CR1 + effector-like cells. Generation of these effector-like cells is essential for the control of chronic infections and tumors, albeit limited. However, the precise cues and mechanisms directing the formation and maintenance of exhausted effector-like are incompletely...
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Oluwagbemiga A Ojo Hongxing Shen Jennifer T Ingram James A Bonner Robert S Welner Georges Lacaud Allan J Zajac Lewis Z Shi Source Type: research
Activation of lysosomal iron triggers ferroptosis in cancer
Res Sq [Preprint]. 2024 Apr 8:rs.3.rs-4165774. doi: 10.21203/rs.3.rs-4165774/v1.ABSTRACTIron catalyses the oxidation of lipids in biological membranes and promotes a form of cell death referred to as ferroptosis 1-3 . Identifying where this chemistry takes place in the cell can inform the design of drugs capable of inducing or inhibiting ferroptosis in various disease-relevant settings. Whereas genetic approaches have revealed underlying mechanisms of lipid peroxide detoxification 1,4,5 , small molecules can provide unparalleled spatiotemporal control of the chemistry at work 6 . Here, we show that the ferroptosis inhibito...
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Rapha ël Rodriguez Tatiana Ca ñeque Leeroy Baron Sebastian M üller Alanis Carmona Ludovic Colombeau Antoine Versini Marie Sabatier Julio Sampaio Eikan Mishima Armel Picard-Bernes St éphanie Solier Jiashuo Zheng Bettina Proneth Leishemba Thoidingjam Ch Source Type: research
E-cigarettes in Nigeria: A scoping review of evidence
CONCLUSION: There is an urgent need for more scientific investigations on the sociodemographic, economic, health, and regulatory landscape of e-cigarettes in Nigeria, as robust empirical evidence is needed for the effective planning, implementation, and evaluation of evidence-based policies and interventions on e-cigarettes control and regulation in Nigeria.PMID:38660005 | PMC:PMC11040567 | DOI:10.1002/hsr2.2074 (Source: Cancer Control)
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Oluwatobi E Adegbile Oluwatomilayo D Adeniji Jimoh Amzat Kehinde K Kanmodi Source Type: research
