Adenosine increases PD-L1 expression in mesenchymal stromal cells derived from cervical cancer through its interaction with A(2A)R/A(2B)R and the production of TGF-beta1
Cell Biochem Funct. 2024 Apr;42(3):e4010. doi: 10.1002/cbf.4010.ABSTRACTMesenchymal stromal cells (MSCs) together with malignant cells present in the tumor microenvironment (TME), participate in the suppression of the antitumor immune response through the production of immunosuppressive factors, such as transforming growth factor beta 1 (TGF-β1). In previous studies, we reported that adenosine (Ado), generated by the adenosinergic activity of cervical cancer (CeCa) cells, induces the production of TGF-β1 by interacting with A2AR/A2BR. In the present study, we provide evidence that Ado induces the production of TGF-β1 in...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Luis Antonio Mar ín-Aquino Mar ía de Lourdes Mora-García Martha C Moreno-Lafont Rosario Garc ía-Rocha Juan Jos é Montesinos-Montesinos Ruben L ópez-Santiago Luvia Enid S ánchez-Torres Daniela Berenice Torres-Pineda Benny Weiss-Steider Jorge Hern á Source Type: research
Time trend analysis of rare cancer incidence 2011-2018: Nationwide population-based cancer registries in Japan
Cancer Sci. 2024 Apr 13. doi: 10.1111/cas.16176. Online ahead of print.ABSTRACTRare cancers collectively account for a significant proportion of the overall cancer burden in Japan. We aimed to describe and examine the incidence of each rare cancer and the temporal changes using the internationally agreed rare cancer classification. Cancer cases registered in regional population-based cancer registries from 2011 to 2015 and the National Cancer Registry (NCR) from 2016 to 2018 were classified into 18 families, 68 Tier-1 cancer groupings, and 216 single cancer entities based on the RARECAREnet list. Crude incidence rates and ...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Hiromi Sugiyama Manami Konda Kumiko Saika Tomohiro Matsuda Source Type: research
The plasma miRNome and venous thromboembolism in high-grade glioma: miRNA Sequencing of a nested case-control cohort
J Cell Mol Med. 2024 Apr;28(8):e18149. doi: 10.1111/jcmm.18149.ABSTRACTPatients with high-grade gliomas are at high risk of venous thromboembolism (VTE). MicroRNAs (miRNAs) are small non-coding RNAs with multiple roles in tumour biology, haemostasis and platelet function. Their association with VTE risk in high-grade glioma has not been comprehensively mapped so far. We thus conducted a nested case-control study within 152 patients with WHO grade IV glioma that had been part of a prospective cohort study on VTE risk factors. At inclusion a single blood draw was taken, and patients were thereafter followed for a maximum of ...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Friedrich Erhart Georg Widhalm Barbara Kiesel Matthias Hackl Andreas Diendorfer Matthias Preusser Karl R össler Johannes Thaler Ingrid Pabinger Cihan Ay Julia Riedl Source Type: research
The long non-coding RNA Meg3 mediates imprinted gene expression during stem cell differentiation
Nucleic Acids Res. 2024 Apr 13:gkae247. doi: 10.1093/nar/gkae247. Online ahead of print.ABSTRACTThe imprinted Dlk1-Dio3 domain comprises the developmental genes Dlk1 and Rtl1, which are silenced on the maternal chromosome in different cell types. On this parental chromosome, the domain's imprinting control region activates a polycistron that produces the lncRNA Meg3 and many miRNAs (Mirg) and C/D-box snoRNAs (Rian). Although Meg3 lncRNA is nuclear and associates with the maternal chromosome, it is unknown whether it controls gene repression in cis. We created mouse embryonic stem cells (mESCs) that carry an ectopic poly(A)...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Sabina Farhadova Amani Ghousein Fran çois Charon Caroline Surcis Melisa Gomez-Velazques Clara Roidor Flavio Di Michele Maud Borensztein Albertina De Sario Cyril Esnault Daan Noordermeer Benoit Moindrot Robert Feil Source Type: research
Evidence-based post-ban research to inform effective menthol cigarette bans in the United States and other jurisdictions
Nicotine Tob Res. 2024 Apr 13:ntae082. doi: 10.1093/ntr/ntae082. Online ahead of print.NO ABSTRACTPMID:38613422 | DOI:10.1093/ntr/ntae082 (Source: Cancer Control)
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Olufemi Erinoso Jennifer L Brown Allison M Glasser Shannon Gravely Geoffrey T Fong Janet Chung-Hall Christina N Kyriakos Alex C Liber Lorraine V Craig Augustus M White Shyanika W Rose Sabrina L Smiley Mitch Zeller Scott Leischow Olalekan Ayo-Yusuf Joanna Source Type: research
Essential oil of the leaves of < em > psychotria asiatica < /em > L.: chemical composition, antioxidant, anti-inflammatory, and cytotoxic properties
This study is focused on investigating the chemical composition and bioactive properties of the essential oil extracted from Psychotria asiatica L., a plant species known for its medicinal properties. Utilising gas chromatography-mass spectrometry (GC-MS) analysis, the essential oil from P. asiatica was found to contain 53 distinct constituents. Major compounds identified include (E)-citral (20.6%), 10-epi-γ-eudesmol (15.9%), (Z)-citral (10.5%), geraniol (7.4%), α-cadinol (6.7%), 7-epi-α-eudesmol (4.4%), linalool (3.7%), and α-muurolol (3.4%). The essential oil did not exhibit antioxidant activity, as indicated by an I...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Tien Dong Tran Anh Tuan Le Dat Van Tran Thang Quoc Le Ty Viet Pham Source Type: research
Liposomal Phenylephrine Nanoparticles Enhance the Antitumor Activity of Intratumoral Chemotherapy in a Preclinical Model of Melanoma
In this study, we aimed to improve the efficacy of intratumoral chemotherapy using a novel approach comprising peri-tumoral injection of sustained-release liposomal nanoparticles containing phenylephrine, which is a potent vasoconstrictor. Using a preclinical model of melanoma, we have previously shown that systemically administered (intravenous) phenylephrine could transiently shunt blood flow to the tumor at the time of drug delivery, which in turn improved antitumor responses. This approach was called dynamic control of tumor-associated vessels. Herein, we used liposomal phenylephrine nanoparticles as a "local" dynamic ...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Emmanuel M Gabriel Deborah Bahr Hari Krishnareddy Rachamala Vijay S Madamsetty Barath Shreeder Sanjay Bagaria Amber L Escobedo Joel M Reid Debabrata Mukhopadhyay Source Type: research
Consensus guidelines for the monitoring and management of metachromatic leukodystrophy in the United States
Cytotherapy. 2024 Apr 1:S1465-3249(24)00579-6. doi: 10.1016/j.jcyt.2024.03.487. Online ahead of print.ABSTRACTMetachromatic leukodystrophy (MLD) is a fatal, progressive neurodegenerative disorder caused by biallelic pathogenic mutations in the ARSA (Arylsulfatase A) gene. With the advent of presymptomatic diagnosis and the availability of therapies with a narrow window for intervention, it is critical to define a standardized approach to diagnosis, presymptomatic monitoring, and clinical care. To meet the needs of the MLD community, a panel of MLD experts was established to develop disease-specific guidelines based on heal...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Laura A Adang Joshua L Bonkowsky Jaap Jan Boelens Eric Mallack Rebecca Ahrens-Nicklas John A Bernat Annette Bley Barbara Burton Alejandra Darling Florian Eichler Erik Eklund Lisa Emrick Maria Escolar Ali Fatemi Jamie L Fraser Amy Gaviglio Stephanie Keller Source Type: research
Association between pre-diagnosis recreational physical activity and risk of breast cancer recurrence: the California Teachers Study
CONCLUSIONS: Our data indicates that the benefit of baseline RPA on BCa recurrence may differ by tumor characteristics. This information may be particularly important for populations at higher risk of ER-PR- BCa.PMID:38613744 | DOI:10.1007/s10552-024-01870-8 (Source: Cancer Control)
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Dan Lin Cheryl L Thompson Alaina Demalis Rebecca Derbes Laila Al-Shaar Emma S Spielfogel Kathleen M Sturgeon Source Type: research
Association between the social vulnerability index and breast, cervical, and colorectal cancer screening rates in Rhode Island
CONCLUSION: The SVI, especially its socioeconomic domain, is a useful tool for identifying areas that are under-served by current efforts to expand access to screening for breast, cervical, and colorectal cancer. These areas should be prioritized for new place-based partnerships that address barriers to screening at the individual and community level.PMID:38613745 | DOI:10.1007/s10552-024-01872-6 (Source: Cancer Control)
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Jihwan Hwang Patricia Markham Risica Eric Lamy William Goedel Source Type: research
Viral infection and spread are inhibited by the polyubiquitination and downregulation of TRPV2 channel by the interferon-stimulated gene TRIM21
Cell Rep. 2024 Apr 12;43(4):114095. doi: 10.1016/j.celrep.2024.114095. Online ahead of print.ABSTRACTInterferon (IFN) contributes to the host's antiviral response by inducing IFN-stimulated genes (ISGs). However, their functional targets and the mechanism of action remain elusive. Here, we report that one such ISG, TRIM21, interacts with and degrades the TRPV2 channel in myeloid cells, reducing its expression and providing host protection against viral infections. Moreover, viral infection upregulates TRIM21 in paracrine and autocrine manners, downregulating TRPV2 in neighboring cells to prevent viral spread to uninfected ...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Yu-Yao Guo Yue Gao Yun-Lin Zhao Chang Xie Hu Gan Xufeng Cheng Li-Ping Yang Junyan Hu Hong-Bing Shu Bo Zhong Dandan Lin Jing Yao Source Type: research
Can proactive support prevent unscheduled care? A controlled observational retrospective cohort study in cancer patients in Scotland
This study hypothesised that ICJ service users should subsequently use less unscheduled care than matched cohorts not using ICJ.METHODS: Retrospective observational cohort study using linked national datasets. N = 1,214 ICJ users in Glasgow were matched for age, sex, deprivation, cancer type, stage, and diagnosis year to two control groups: 1. Cancer patients from Glasgow before ICJ (pre-2014), 2. Cancer patients from rest of Scotland during study period (2014-2018). Cancer registrations were linked for 12-month baseline and study periods to: NHS24 calls, A&E admissions, inpatient hospital admissions, unscheduled care,...
Source: Cancer Control - April 12, 2024 Category: Cancer & Oncology Authors: Austyn Snowden Jenny Young Jan Savinc Source Type: research
Circ-10720 as a ceRNA adsorbs microRNA-1238 and modulates ZEB2 to boost NSCLC development by activating EMT
CONCLUSIONS: Circ-10720 acts as a ceRNA to adsorb miR-1238 and modulate ZEB2 to facilitate the proliferation, migration, invasion, and EMT of NSCLC cells.PMID:38610009 | DOI:10.1186/s40001-024-01715-9 (Source: Cancer Control)
Source: Cancer Control - April 12, 2024 Category: Cancer & Oncology Authors: Wei Zhang Ping Xiao Bin Liu Yan Zhang Source Type: research
Ganoderma spore lipid ameliorates docetaxel, cisplatin, and 5-fluorouracil chemotherapy-induced damage to bone marrow mesenchymal stem cells and hematopoiesis
CONCLUSIONS: GSL efficiently protected BMSCs from damage caused by TPF and recovered hematopoiesis.PMID:38610025 | DOI:10.1186/s12906-024-04445-x (Source: Cancer Control)
Source: Cancer Control - April 12, 2024 Category: Cancer & Oncology Authors: Haohui Lin Manhon Chung Jingchun Sun Yi Yang Li Zhang Xiaohua Pan Minghui Wei Sa Cai Yu Pan Source Type: research
Development of nanobodies targeting hepatocellular carcinoma and application of nanobody-based CAR-T technology
CONCLUSIONS: In summary, the results of this study suggest that the CAR-T cells derived from high specificity and high affinity Nbs, targeting FGFR4, exhibited significantly enhanced anti-tumor efficacy in vitro and in vivo. This is an exploration of FGFR4 in the field of Nb-derived CAR-T cell therapy for HCC, holding promise for enhancing safety and effectiveness in the clinical treatment of HCC in the future.PMID:38610029 | DOI:10.1186/s12967-024-05159-x (Source: Cancer Control)
Source: Cancer Control - April 12, 2024 Category: Cancer & Oncology Authors: Keming Lin Baijin Xia Xuemei Wang Xin He Mo Zhou Yingtong Lin Yidan Qiao Rong Li Qier Chen Yuzhuang Li Jinzhu Feng Tao Chen Cancan Chen Xinyu Li Hui Zhang Lijuan Lu Bingfeng Liu Xu Zhang Source Type: research
