Identification of Lower Grade Glioma Antigens Based on Ferroptosis Status for mRNA Vaccine Development
CONCLUSION: HOTAIR, IDO1, KIF20A, NR5A2, and RRM2 were identified as promising candidate antigens for the development of an LGG mRNA vaccine, particularly offering potential benefits to FS2 and FS4 patients.PMID:38623558 | PMC:PMC11018127 | DOI:10.2147/PGPM.S449230 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Zhenxiang Zhao Na Xing Hao Guo Jianfeng Li Guozhu Sun Source Type: research
Epstein-Barr Virus DNA Is Associated With Conjunctival Squamous Cell Carcinomas: A Case-Control Study From Zimbabwe
Open Forum Infect Dis. 2024 Mar 25;11(4):ofae165. doi: 10.1093/ofid/ofae165. eCollection 2024 Apr.ABSTRACTIncidence of conjunctival squamous cell carcinoma (cSCC) in Zimbabwe is >30-fold higher than the global average. cSCC risk is notably higher among people with human immunodeficiency virus, implicating impaired immune response and a yet unknown infectious etiology. Formalin-fixed, paraffin-embedded blocks from Zimbabwe, comprising conjunctival precancer (n = 78), invasive cSCC cases (n = 148) and nonmalignant eye lesions (n = 119), were tested for multiple DNA viruses using Luminex bead-based technology. Epstein-Barr...
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Racheal S Dube Mandishora Luisa Galati Richard R Reich Jean-Damien Combes Sandrine McKay-Chopin Rudo Makunike-Mutasa Rangarirai Masanganise Bevele Gwambiwa Tricia Magombei Francesco Alfredo Zito Pagona Lagiou Gary M Clifford Anna R Giuliano Anna E Coghill Source Type: research
Thymosin alpha1 combined with XELOX improves immune function and reduces serum tumor markers in colorectal cancer patients after radical surgery
This study aimed to investigate the efficacy of thymosin α1 combined with XELOX in improving immune function and reducing serum tumor markers in patients with colorectal cancer (CRC) after radical surgery. A total of 180 patients who underwent radical surgery for CRC were divided into two groups: an observation group (n = 94) receiving thymosin α1 in combination with XELOX and a control group (n = 86) receiving XELOX alone. Immune function, inflammatory factor levels, serum tumor markers, and quality of life were assessed before and after treatment. Adverse reactions and recurrence rates were compared between the two gro...
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Li Sha Hao Zhang Xiwei Zhang Source Type: research
Application Value of CYFRA21-1 Combined with NSE, CEA, and SCC-Ag in Lung Cancer
CONCLUSIONS: The combined assay of CYFRA21-1, NSE, and CEA addresses the aspects of accuracy, sensitivity, specificity, and economic cost and should be considered as a potential diagnostic test in LC.PMID:38623667 | DOI:10.7754/Clin.Lab.2023.230662 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Yuping Fu Dandan Li Ya Zhu Sha Yan Xia Wang Zhenshuai Lian Qi Xie Zhi'an He Source Type: research
Comprehensive Assessment of the Intrinsic Pancreatic Microbiome
CONCLUSIONS: Our analysis of the pancreatic microbiome demonstrated very low intrinsic biomass that is relatively conserved across diverse neoplastic conditions and thus unlikely to drive malignant transformation.PMID:38623754 | DOI:10.1097/SLA.0000000000006299 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Austin M Eckhoff Ashley A Fletcher Matthew S Kelly Anders Dohlman Caitlin A McIntyre Xiling Shen Matthew K Iyer Daniel P Nussbaum Peter J Allen Source Type: research
Continuous immunotherapy beyond progression in clinical practice for small cell lung cancer
We describe the effectiveness of continuous ICIs beyond progression in SCLC. Medical courses of SCLC patients treated with chemo-immunotherapy were retrospectively reviewed at our hospital. The study included 36 patients with a median age of 73 years (range 46-83 years) who introduced chemo-immunotherapy between September 2019 and December 2022. Atezolizumab and durvalumab in combination with platinum plus etoposide were administered in 24 and 12 patients, respectively. The overall response rate was 67% and the disease control rate was 86%. The median progression-free survival and time to treatment failure (TTF) were 5.1 a...
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Ken Yamamoto Taira Ninomaru Hideaki Okada Katsuya Hirano Temiko Shimada Akito Hata Source Type: research
Investigating Disparities in Hypopharyngeal/Laryngeal Cancer Survival in Florida With Geospatial Mapping Analysis
CONCLUSION: Our findings suggest that sociodemographic and clinical factors impact OS from hypopharyngeal/laryngeal cancer in Florida and vary geographically within the state. These results will help guide future public health interventions.PMID:38623948 | DOI:10.1177/10732748241246958 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Uche C Ezeh Abdurrahman Al-Awady Isabella Buitron Ming Lee Garrett Forman Sophia Peifer Alana Deo Larissa Sweeny Donald Weed Erin K Kobetz Isildinha M Reis Elizabeth Franzmann Source Type: research
Self-Assembled Recombinant Elastin and Globular Protein Vesicles with Tunable Properties for Diverse Applications
Acc Chem Res. 2024 Apr 16. doi: 10.1021/acs.accounts.3c00694. Online ahead of print.ABSTRACTConspectusVesicles are self-assembled structures comprised of a membrane-like exterior surrounding a hollow lumen with applications in drug delivery, artificial cells, and micro-bioreactors. Lipid or polymer vesicles are the most common and are made of lipids or polymers, respectively. They are highly useful structures for many applications but it can be challenging to decorate them with proteins or encapsulate proteins in them, owing to the use of organic solvent in their formation and the large size of proteins relative to lipid o...
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Mikaela A Gray Mariela R Rodriguez-Otero Julie A Champion Source Type: research
Investigating the role connective tissue fibroblasts play in the altered muscle anatomy associated with the limb abnormality, Radial Dysplasia
J Anat. 2024 Apr 16. doi: 10.1111/joa.14040. Online ahead of print.ABSTRACTRadial dysplasia (RD) is a congenital upper limb birth defect that presents with changes to the upper limb anatomy, including a shortened or absent radius, bowed ulna, thumb malformations, a radially deviated hand and a range of muscle and tendon malformations, including absent or abnormally shaped muscle bundles. Current treatments to address wrist instability caused by a shortened or absent radius frequently require an initial soft tissue distraction intervention followed by a wrist stabilisation procedure. Following these surgical interventions, ...
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: George R F Murphy Eleanor Feneck James Paget Branavan Sivakumar Gill Smith Malcolm P O Logan Source Type: research
Platinum-based adjuvant chemoradiotherapy versus adjuvant radiotherapy in patients with head and neck adenoid cystic carcinoma
CONCLUSION: In terms of reducing locoregional failures in HNACC patients, POCRT may potentially offer a more effective therapeutic approach than using PORT alone, although it also entails an augmented burden of treatment-related toxicity.PMID:38625410 | DOI:10.1007/s00432-024-05719-0 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Zichen Qiu Zheng Wu Xiong Zhou Minchuan Lin Yong Su Yalan Tao Source Type: research
Phase I/II study of stereotactic body radiotherapy boost in patients with cervical cancer ineligible for intracavitary brachytherapy
CONCLUSION: These findings suggested that a SBRT boost is more effective than the conventional EBRT boost and can be an important treatment option for ICBT-ineligible patients with cervical cancer.STUDY REGISTRATION: This study was registered at the University Hospital Medical Information Network Clinical Trials Registry (UMIN000036845).PMID:38625476 | DOI:10.1007/s11604-024-01566-8 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Kei Ito Yujiro Nakajima Hiroaki Ogawa Akiko Furusawa Keiko Nemoto Murofushi Satoshi Kito Nao Kino Toshiharu Yasugi Takashi Uno Katsuyuki Karasawa Source Type: research
Exploration of efficacy of different therapy regimens for advanced NSCLC patients with KRAS mutation in the first-line treatment
CONCLUSION: In the first-line treatment, combination regimen has advantages over single regimen. Among them, chemotherapy combined with immunotherapy plus antiangiogenic therapy can achieve significant efficacy benefits.PMID:38625494 | DOI:10.1007/s12094-024-03485-6 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Ke Wang Manyi Xu Yanhua Wang Chunwei Xu Yue Hao Zhengbo Song Source Type: research
A single-arm pilot of MyInspiration: a novel digital resource to support spiritual needs of patients undergoing cancer-directed surgery
CONCLUSION: MyInspiration was feasible and acceptable to patients, and the majority were satisfied with the tool. The intervention was associated with changes in patients' ability to find meaning within their cancer experience. A randomized control trial is needed to evaluate the efficacy of the tool in a broader population of patients with cancer.PMID:38625539 | DOI:10.1007/s00520-024-08496-1 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Elizabeth Palmer Kelly Maryanna Klatt Jacqueline Caputo Timothy M Pawlik Source Type: research
Imaging extrachromosomal DNA (ecDNA) in cancer
Histochem Cell Biol. 2024 Apr 16. doi: 10.1007/s00418-024-02280-2. Online ahead of print.ABSTRACTExtrachromosomal DNA (ecDNA) are circular regions of DNA that are found in many cancers. They are an important means of oncogene amplification, and correlate with treatment resistance and poor prognosis. Consequently, there is great interest in exploring and targeting ecDNA vulnerabilities as potential new therapeutic targets for cancer treatment. However, the biological significance of ecDNA and their associated regulatory control remains unclear. Light microscopy has been a central tool in the identification and characterisat...
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Karin Purshouse Steven M Pollard Wendy A Bickmore Source Type: research
Defining distal splenopancreatectomy by the mesopancreas
CONCLUSION: While resection margin status was not affected by the MP status in dPDAC patients, the high MP infiltration rate, as well as improved survival in MP- dPDAC patients after R0CRM- resection, justify mesopancreatic excision during splenopancreatectomy. Larger scale studies are urgently needed to validate our results and to study the effect on neoadjuvant treatment in dPDAC patients.PMID:38625602 | DOI:10.1007/s00423-024-03320-0 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: S-A Safi A Alexander W Neuhuber L Haeberle A Rehders T Luedde I Esposito G Fluegen W T Knoefel Source Type: research
