Elevation of S2-bound α1-acid glycoprotein is associated with chronic hepatitis C virus infection and hepatocellular carcinoma
J Viral Hepat. 2024 Apr 12. doi: 10.1111/jvh.13943. Online ahead of print.ABSTRACTThere is an urgent need for new high-quality markers for the early detection of hepatocellular carcinoma (HCC). Åström et al. suggested that S2-bound α1-acid glycoprotein (AGP) might be a promising marker. Consequently, we evaluated the predictive advantage of S2-bound AGP in the early detection of HCC. In a retrospective case-control study of patients chronically infected with hepatitis C virus (HCV) and treated with direct-acting antiviral agents (n = 93), we measured S2-bound AGP using the HepaCheC® ELISA kit (Glycobond AB, Linköping,...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Carlos Oltmanns Birgit Bremer Laura Kusche Per St ål Robin Zenlander Jan Tauwaldt Ingvar Ryd én Peter P åhlsson Markus Cornberg Heiner Wedemeyer Source Type: research
Analgesic Efficacy and Safety of Intrathecal Morphine or Intercostal Levobupivacaine in Lung Cancer Patients after Major Lung Resection Surgery by Videothoracoscopy: A Prospective Randomized Controlled Trial
Conclusions: ITM can be considered an adequate and satisfactory regional technique for the control of acute postoperative pain in VATS, compatible with the multimodal rehabilitation and early discharge protocols used in these types of surgeries.PMID:38610735 | DOI:10.3390/jcm13071972 (Source: Cancer Control)
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Silvia Gonz ález-Santos Borja Mugabure Manuel Granell Borja Aguinagalde Iker J L ópez Ainhoa Aginaga Inmaculada Zubelzu Haritz Iraeta Jon Zabaleta Jose Miguel Izquierdo Nuria Gonz ález-Jorrín Cristina Sarasqueta Alejandro Herreros-Pomares Source Type: research
IMPROVE-BMT: A Pilot Randomized Controlled Trial of Prehabilitation Exercise for Adult Hematopoietic Stem Cell Transplant Recipients
Conclusions: IMPROVE-BMT demonstrates that pragmatic exercise is highly feasible for HSCT recipients and can potentially lead to enhanced recovery that may not be achievable in non-exercisers.PMID:38610816 | DOI:10.3390/jcm13072052 (Source: Cancer Control)
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Melanie Potiaumpai Maxime Caru Shin Mineishi Seema Naik Babette S Zemel Kathryn H Schmitz Source Type: research
Intracranial Efficacy of Atezolizumab, Bevacizumab, Carboplatin, and Paclitaxel in Real-World Patients with Non-Small-Cell Lung Cancer and EGFR or ALK Alterations
Cancers (Basel). 2024 Mar 22;16(7):1249. doi: 10.3390/cancers16071249.ABSTRACTContrary to Pemetrexed-containing chemo-immunotherapy studies, Atezolizumab, Bevacizumab, Carboplatin, and Paclitaxel (ABCP) treatment has consistently shown clinical benefit in prospective studies in patients with lung cancer and actionable mutations, where intracranial metastases are common. Here, we aimed to describe the real-life population of patients fit to receive ABCP after targeted therapy and quantify its clinical effect in patients with brain metastases. Patients treated in Cheshire and Merseyside between 2019 and 2022 were identified....
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Marcus Rathbone Conor O'Hagan Helen Wong Adeel Khan Timothy Cook Sarah Rose Jonathan Heseltine Carles Escriu Source Type: research
< em > Ianus Bifrons < /em > : The Two Faces of Metformin
Cancers (Basel). 2024 Mar 26;16(7):1287. doi: 10.3390/cancers16071287.ABSTRACTThe ancient Roman god Ianus was a mysterious divinity with two opposite faces, one looking at the past and the other looking to the future. Likewise, metformin is an "old" drug, with one side looking at the metabolic role and the other looking at the anti-proliferative mechanism; therefore, it represents a typical and ideal bridge between diabetes and cancer. Metformin (1,1-dimethylbiguanidine hydrochloride) is a drug that has long been in use for the treatment of type 2 diabetes mellitus, but recently evidence is growing about its potential use ...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Umberto Goglia Iderina Hasballa Claudia Teti Mara Boschetti Diego Ferone Manuela Albertelli Source Type: research
Non-Surgical Bladder-Sparing Multimodal Management in Organ-Confined Urothelial Carcinoma of the Urinary Bladder: A Population-Based Analysis
CONCLUSIONS: Strict trimodal therapy that includes both CT and RT after TURBT offers the best cancer control. When strict trimodal therapy cannot be delivered, cancer-specific survival outcomes appear to be superior with TURBT + chemotherapy compared to TURBT + RT.PMID:38610970 | DOI:10.3390/cancers16071292 (Source: Cancer Control)
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Mario de Angelis Andrea Baudo Carolin Siech Letizia Maria Ippolita Jannello Francesco Di Bello Jordan A Goyal Zhe Tian Nicola Longo Ottavio de Cobelli Felix K H Chun Fred Saad Shahrokh F Shariat Luca Carmignani Giorgio Gandaglia Marco Moschini Francesco M Source Type: research
Causes of Childhood Cancer: A Review of the Recent Literature: Part I-Childhood Factors
Cancers (Basel). 2024 Mar 27;16(7):1297. doi: 10.3390/cancers16071297.ABSTRACTPURPOSE: To review the childhood risk factors for pediatric cancer (diagnosis before age 20).METHODS: We conducted literature searches using Ovid Medline and Scopus to find primary research studies, review articles, and meta-analyses published from 2014 to 3 March 2021.RESULTS: Strong evidence indicates that an array of genetic and epigenetic phenomena, structural birth defects, and chromosomal anomalies are associated with an increased risk of various childhood cancers. Increased risk is also associated with prior cancer, likely due to previous ...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Angela M Ricci Rebecca T Emeny Pamela J Bagley Heather B Blunt Mary E Butow Alexandra Morgan Jennifer A Alford-Teaster Linda Titus Raymond R Walston Judy R Rees Source Type: research
Antineoplastic Drug Synergy of Artesunate with Navitoclax in Models of High-Grade Serous Ovarian Cancer
Cancers (Basel). 2024 Mar 28;16(7):1321. doi: 10.3390/cancers16071321.ABSTRACTArtesunate belongs to a class of medications derived from the sweet wormwood plant (Artemisia annua) known as artemisinins. Artesunate has traditionally been used as a frontline treatment for severe malaria but has also demonstrated antineoplastic activity against various malignancies, including ovarian cancer. Data suggest that artesunate exacerbates cellular oxidative stress, triggering apoptosis. In the current study, we investigated the ability of navitoclax, an inhibitor of the antiapoptotic Bcl-2 protein family, to enhance artesunate effica...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: J Robert McCorkle Rebecca Ahn Connie D Cao Kristen S Hill Charles S Dietrich Jill M Kolesar Source Type: research
Peripheral T Cell Subpopulations as a Potential Surrogate Biomarker during Atezolizumab plus Bevacizumab Treatment for Hepatocellular Carcinoma
In conclusion, TCM proportion at baseline might be a good indicator of the efficacy of Atez/Bev therapy. Furthermore, observation of increasing TEM proportions might be an early predictor of the potential clinical benefits of treatment.PMID:38611007 | DOI:10.3390/cancers16071328 (Source: Cancer Control)
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Yuki Shirane Yasutoshi Fujii Atsushi Ono Hikaru Nakahara Clair Nelson Hayes Ryoichi Miura Serami Murakami Naoya Sakamoto Shinsuke Uchikawa Hatsue Fujino Takashi Nakahara Eisuke Murakami Masami Yamauchi Daiki Miki Tomokazu Kawaoka Koji Arihiro Masataka Tsu Source Type: research
Association of Insomnia and Obstructive Sleep Apnea with Worse Oral Mucositis and Quality of Life in Head and Neck Cancer Patients Undergoing Radiation Therapy
CONCLUSION: Insomnia and OSA are highly prevalent in patients with HNC undergoing RT. These sleep disturbances are associated with worse QOL and OM during treatment.PMID:38611012 | DOI:10.3390/cancers16071335 (Source: Cancer Control)
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Austin J Iovoli Kelsey Smith Han Yu Melissa A Kluczynski Carla R Jungquist Andrew D Ray Mark K Farrugia Fangyi Gu Anurag K Singh Source Type: research
Reducing State Conflicts between Network Motifs Synergistically Enhances Cancer Drug Effects and Overcomes Adaptive Resistance
Cancers (Basel). 2024 Mar 29;16(7):1337. doi: 10.3390/cancers16071337.ABSTRACTInducing apoptosis in cancer cells is a primary goal in anti-cancer therapy, but curing cancer with a single drug is unattainable due to drug resistance. The complex molecular network in cancer cells causes heterogeneous responses to single-target drugs, thereby inducing an adaptive drug response. Here, we showed that targeted drug perturbations can trigger state conflicts between multi-stable motifs within a molecular regulatory network, resulting in heterogeneous drug responses. However, we revealed that properly regulating an interconnecting m...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Yunseong Kim Sea Rom Choi Kwang-Hyun Cho Source Type: research
Association between Head and Neck Cancer and Increased Risk of Ischemic Heart Disease: A Retrospective Cohort Study Using National Population Data
Cancers (Basel). 2024 Mar 29;16(7):1352. doi: 10.3390/cancers16071352.ABSTRACTAlthough cancer and ischemic heart disease (IHD) frequently manifest in the same individual, the risk of IHD events in cancer, especially head and neck cancer (HNC), remains unclear. We aimed to examine the incidence and risk of IHD events in patients with HNC using a population-based cohort dataset in South Korea (2002-2013). Through rigorous propensity score matching, we compared data from 2816 individuals without HNC and 704 individuals with HNC. Key independent variables were matched between groups, and the Charlson Comorbidity Index was used...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Chulho Kim Hyunjae Yu Dong-Kyu Kim Source Type: research
Utility Scores for Risk-Reducing Mastectomy and Risk-Reducing Salpingo-Oophorectomy: Mapping to EQ-5D
CONCLUSIONS: We present the first HRUSs sourced from patients following RRM and RRSO. There is a need for high-quality prospective studies to characterise quality of life at different timepoints.PMID:38611036 | DOI:10.3390/cancers16071358 (Source: Cancer Control)
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Samuel G Oxley Xia Wei Michail Sideris Oleg Blyuss Ashwin Kalra Jacqueline J Y Sia Subhasheenee Ganesan Caitlin T Fierheller Li Sun Zia Sadique Haomiao Jin Ranjit Manchanda Rosa Legood Source Type: research
Biomarkers for Pre-Treatment Risk Stratification of Prostate Cancer Patients: A Systematic Review
CONCLUSION: This systematic review unveils the substantial clinical promise of using circulating biomarkers in assessing the risk for prostate cancer patients. However, the standardization of groups, categories, and biomarker validation are mandatory before this technique can be implemented. Circulating biomarkers might represent a viable alternative to currently available tools, obviating the need for tissue biopsies, and allowing for faster and more cost-effective testing, with superior analytical performance, specificity, and reproducibility.PMID:38611041 | DOI:10.3390/cancers16071363 (Source: Cancer Control)
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Jos é Pedro Sequeira Sofia Salta Rui Freitas Rafael L ópez-López Ángel Díaz-Lagares Rui Henrique Carmen Jer ónimo Source Type: research
Long-Term Oral Tamoxifen Administration Decreases Brain-Derived Neurotrophic Factor in the Hippocampus of Female Long-Evans Rats
Cancers (Basel). 2024 Mar 31;16(7):1373. doi: 10.3390/cancers16071373.ABSTRACTTamoxifen, a selective estrogen receptor modulator (SERM), is commonly used as an adjuvant drug therapy for estrogen-receptor-positive breast cancers. Though effective at reducing the rate of cancer recurrence, patients often report unwanted cognitive and affective side effects. Despite this, the impacts of chronic tamoxifen exposure on the brain are poorly understood, and rodent models of tamoxifen exposure do not replicate the chronic oral administration seen in patients. We, therefore, used long-term ad lib consumption of medicated food pellet...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Laura E Been Amanda R Halliday Sarah M Blossom Elena M Bien Anya G Bernhard Grayson E Roth Karina I Domenech Rosario Karlie B Pollock Petra E Abramenko Leily M Behbehani Gabriel J Pascal Mary Ellen Kelly Source Type: research
