Exploration of drug resistance mechanisms in triple negative breast cancer cells using a microfluidic device and patient tissues
In this study, we utilized a microfluidic device to induce the development of doxorubicin-resistant (DOXR) cells from triple negative breast cancer (TNBC) cells within 11 days by generating gradients of DOX and medium. In vivo chemoresistant xenograft models, an unbiased genome-wide transcriptome analysis, and a patient data/tissue analysis all showed that chemoresistance arose from failed epigenetic control of the nuclear protein-1 (NUPR1)/histone deacetylase 11 (HDAC11) axis, and high NUPR1 expression correlated with poor clinical outcomes. These results suggest that the chip can rapidly induce resistant cells that incre...
Source: Cancer Control - March 27, 2024 Category: Cancer & Oncology Authors: Wanyoung Lim Inwoo Hwang Jiande Zhang Zhenzhong Chen Jeonghun Han Jaehyung Jeon Bon-Kyoung Koo Sangmin Kim Jeong Eon Lee Youngkwan Kim Kenneth J Pienta Sarah R Amend Robert H Austin Jee-Yin Ahn Sungsu Park Source Type: research

Case weighted power priors for hybrid control analyses with time-to-event data
Biometrics. 2024 Mar 27;80(2):ujae019. doi: 10.1093/biomtc/ujae019.ABSTRACTWe develop a method for hybrid analyses that uses external controls to augment internal control arms in randomized controlled trials (RCTs) where the degree of borrowing is determined based on similarity between RCT and external control patients to account for systematic differences (e.g., unmeasured confounders). The method represents a novel extension of the power prior where discounting weights are computed separately for each external control based on compatibility with the randomized control data. The discounting weights are determined using th...
Source: Cancer Control - March 27, 2024 Category: Cancer & Oncology Authors: Evan Kwiatkowski Jiawen Zhu Xiao Li Herbert Pang Grazyna Lieberman Matthew A Psioda Source Type: research

Long-term cardiovascular risk reduction after gastric cancer surgery: a nationwide cohort study
CONCLUSION: Patients with gastric cancer who have undergone gastrectomy exhibit a reduced risk of cardiovascular diseases in comparison to the general population. In contrast, the risk for cardiovascular diseases in patients with gastric cancer who underwent endoscopic resection did not demonstrate a significant difference in cardiovascular risk in comparison to the general population.PMID:38537066 | DOI:10.1097/JS9.0000000000001404 (Source: Cancer Control)
Source: Cancer Control - March 27, 2024 Category: Cancer & Oncology Authors: Yeongkeun Kwon Dohyang Kim Sangwoo Kim Jane Ha Jinseub Hwang Sungsoo Park Jin-Won Kwon Source Type: research

The role of robotic-assisted surgery in the management of rectal cancer: a systematic review and meta-analysis
CONCLUSION: Robotic-assisted surgery (RAS) demonstrates favourable outcomes for rectal cancer patients, contributing to global prevention and control efforts, health promotion, and addressing non-communicable disease risk factors. Further research and public awareness are needed to optimize RAS utilization in this context.PMID:38537073 | DOI:10.1097/JS9.0000000000001380 (Source: Cancer Control)
Source: Cancer Control - March 27, 2024 Category: Cancer & Oncology Authors: Chenxion Zhang Hao Tan Han Xu Jiaming Ding Source Type: research

Development and Validation of a Machine Learning Prognostic Model of m5C Related immune Genes in Lung Adenocarcinoma
CONCLUSIONS: The prognostic signature comprised of HLA-DMB, PPIA, and GPI based on m5C-IRGs was established, which might provide theoretical basis and reference value for the research of LUAD.PUBLIC DATASETS ANALYZED IN THE STUDY: TCGA-LUAD dataset was collected from the TCGA (https://portal.gdc.cancer.gov/) database, GSE31210 (validation set) was retrieved from GEO (https://www.ncbi.nlm.nih.gov/geo/) database.PMID:38537151 | DOI:10.1177/10732748241237414 (Source: Cancer Control)
Source: Cancer Control - March 27, 2024 Category: Cancer & Oncology Authors: Xiong Cao Yuxing Ji Jiajia Li Zhikang Liu Chang Chen Source Type: research

Cyclophosphamide stimulates endoplasmic reticulum stress and induces apoptotic cell death in human glioblastoma cell lines
In this study, we aimed to investigate the effects of 4-Hydroperoxy cyclophosphamide (4-HC), which is active form of CP, on glucose-regulated protein 78 (GRP78), activating transcription factor 6 (ATF6), phospho-protein kinase R (PKR)-like endoplasmic reticulum (ER) kinase (p-PERK), phospho-inositol-requiring enzyme 1 alpha (p-IRE1α), eukaryotic translation initiation factor 2 alpha (eIF2α), and caspase-3 messenger ribonucleic acids (mRNAs) and proteins that play roles in the ER stress pathway and apoptosis in U87 and T98 human glioblastoma cell lines. U87 and T98 human glioblastoma cell lines were divided into control a...
Source: Cancer Control - March 26, 2024 Category: Cancer & Oncology Authors: Mustafa Oztatlici Hulya Oztatlici Suna Karadeniz Saygili Ismail Kaya Ilker Deniz Cingoz Source Type: research

Secondary use of genomic data: patients' decisions at point of testing and perspectives to inform international data sharing
Eur J Hum Genet. 2024 Mar 25. doi: 10.1038/s41431-023-01531-5. Online ahead of print.ABSTRACTInternational sharing of genomic data files arising from clinical testing of patients is essential to further improve genomic medicine. Whilst the general public are reluctant to donate DNA for research, the choices patients actually make about sharing their clinical genomic data for future re-use (research or clinical) are unknown. We ascertained the data-sharing choices of 1515 patients having genomic testing for inherited conditions or cancer treatment from clinical consent forms. To understand the experiences and preferences of...
Source: Cancer Control - March 26, 2024 Category: Cancer & Oncology Authors: Melissa Martyn Emily Forbes Ling Lee Anaita Kanga-Parabia Rona Weerasuriya Elly Lynch Penny Gleeson Clara Gaff Source Type: research

Menopausal status induces vaginal dysbiosis in women with human papillomavirus infection
In this study, we examined the difference in the vaginal microbiota of women infected with human papillomavirus (HPV), according to menopausal status. A total of 75 cervicovaginal swab samples from 38 pre- and 37 postmenopausal women with HPV infection were obtained from the Korean HPV cohort. Vaginal microbiota analysis, including microbial diversity and specific bacterial abundances, was performed using 16S rRNA gene sequencing. The mean age of the pre- and postmenopausal women were 29.5 and 55.8 years, respectively (p < 0.0001). Lactobacillus spp. were predominant in both groups; however, a marked decrease was observ...
Source: Cancer Control - March 26, 2024 Category: Cancer & Oncology Authors: Kyeong A So Soo Young Hur Chi Heum Cho Jae Kwan Lee Seok Ju Seong Dae Hoon Jeong Moran Ki Tae Jin Kim Source Type: research

Extend the benchmarking indel set by manual review using the individual cell line sequencing data from the Sequencing Quality Control 2 (SEQC2) project
Sci Rep. 2024 Mar 25;14(1):7028. doi: 10.1038/s41598-024-57439-7.ABSTRACTAccurate indel calling plays an important role in precision medicine. A benchmarking indel set is essential for thoroughly evaluating the indel calling performance of bioinformatics pipelines. A reference sample with a set of known-positive variants was developed in the FDA-led Sequencing Quality Control Phase 2 (SEQC2) project, but the known indels in the known-positive set were limited. This project sought to provide an enriched set of known indels that would be more translationally relevant by focusing on additional cancer related regions. A thorou...
Source: Cancer Control - March 26, 2024 Category: Cancer & Oncology Authors: Binsheng Gong Dan Li Yifan Zhang Rebecca Kusko Samir Lababidi Zehui Cao Mingyang Chen Ning Chen Qiaochu Chen Qingwang Chen Jiacheng Dai Qiang Gan Yuechen Gao Mingkun Guo Gunjan Hariani Yujie He Wanwan Hou He Jiang Garima Kushwaha Jian-Liang Li Jianying Li Source Type: research

Ketotifen directly modifies the fibrotic response of human skin fibroblasts
Sci Rep. 2024 Mar 25;14(1):7076. doi: 10.1038/s41598-024-57776-7.ABSTRACTFibrosis is a destructive, end-stage disease process. In the skin, it is associated with systemic sclerosis and scarring with considerable health burden. Ketotifen is a clinical antihistamine and mast cell stabilizer. Studies have demonstrated mast cell-dependent anti-fibrotic effects of ketotifen but direct effects on fibroblasts have not been determined. Human dermal fibroblasts were treated with pro-fibrotic transforming growth factor-β1 (TGFβ) followed by ketotifen or control treatments to determine direct effects on fibrotic fibroblasts. Ketoti...
Source: Cancer Control - March 26, 2024 Category: Cancer & Oncology Authors: Edwin Leong Haya Al-Bitar Jean S Marshall Michael Bezuhly Source Type: research

A randomized controlled study to assess the effect of mosapride citrate on intestinal recovery following gastrectomy
Sci Rep. 2024 Mar 25;14(1):7030. doi: 10.1038/s41598-024-57870-w.ABSTRACTThe enhanced recovery after surgery (ERAS) protocol, including prokinetic medications, is commonly used to prevent postoperative ileus. Prospective studies evaluating the effectiveness of mosapride citrate, a prokinetic 5-hydroxytryptamine 4 receptor agonist, in patients undergoing gastrectomy within the ERAS framework are lacking. This double-blind randomized trial included patients who were scheduled for laparoscopic or robotic gastrectomy for gastric cancer. Participants were randomly assigned to either a control (placebo) or experimental (mosaprid...
Source: Cancer Control - March 26, 2024 Category: Cancer & Oncology Authors: Shiyeol Jun Seyeol Oh Ji Eun Jung In Gyu Kwon Sung Hoon Noh Source Type: research

Nanoparticle drug delivery systems responsive to tumor microenvironment: Promising alternatives in the treatment of triple-negative breast cancer
This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.PMID:38528388 | DOI:10.1002/wnan.1950 (Source: Cancer Control)
Source: Cancer Control - March 26, 2024 Category: Cancer & Oncology Authors: Ye Cao Fansu Meng Tiange Cai Lanwen Gao Jaiwoo Lee Sergey O Solomevich Uladzislau E Aharodnikau Tingting Guo Meng Lan Fengjie Liu Qianwen Li Timoshenko Viktor Detang Li Yu Cai Source Type: research

Changes in disease burden and global inequalities in bladder, kidney and prostate cancers from 1990 to 2019: a comparative analysis based on the global burden of disease study 2019
CONCLUSIONS: Different patterns of inequality were observed in the three cancers, necessitating tailored national cancer control strategies to mitigate disparities. Priority interventions for bladder and kidney cancer should target higher socioeconomic regions, whereas interventions for prostate cancer should prioritize the lowest socioeconomic regions. Additionally, addressing higher inequality in males requires more intensive interventions among males from higher socioeconomic regions.PMID:38528465 | DOI:10.1186/s12889-024-18353-9 (Source: Cancer Control)
Source: Cancer Control - March 26, 2024 Category: Cancer & Oncology Authors: Qiao Huang Jun Yang Guo-Xiong Liu Hao Zi Shi-Di Tang Hai-Chang Jia Wei Li Xiao-Feng Xu Xian-Tao Zeng Source Type: research

Formononetin reverses Treg/Th17 imbalance in immune-mediated bone marrow failure mice by regulating the PI3K/Akt signaling pathway
CONCLUSIONS: FMN alleviates immune-mediated BMF by modulating the balance of Treg/Th17 cells through the PI3K/Akt signaling pathway.PMID:38528555 | DOI:10.1186/s13020-024-00919-9 (Source: Cancer Control)
Source: Cancer Control - March 26, 2024 Category: Cancer & Oncology Authors: Huixuan Lan Wei Qiu Jie Wu Zhijing Hu Xiaomin Zhang Lingling Zhu Source Type: research

Single-cell RNA sequencing reveals recruitment of the M2-like CCL8 < sup > high < /sup > macrophages in Lewis lung carcinoma-bearing mice following hypofractionated radiotherapy
CONCLUSIONS: Hypofractionated radiotherapy enhances the infiltration of CCL8high macrophages and amplifies their roles in macrophage recruitment through the CCL signaling pathway, leading to an immunosuppressive tumor microenvironment. These findings highlight the potential of targeting TAMs and introduces a novel combination to improve the efficacy of hypofractionated radiotherapy.PMID:38528587 | DOI:10.1186/s12967-024-05118-6 (Source: Cancer Control)
Source: Cancer Control - March 26, 2024 Category: Cancer & Oncology Authors: Haonan Yang Zheng Lei Jiang He Lu Zhang Tangmin Lai Liu Zhou Nuohan Wang Zheng Tang Jiangdong Sui Yongzhong Wu Source Type: research