Lonidamine Induced Selective Acidification and De-Energization of Prostate Cancer Xenografts: Enhanced Tumor Response to Radiation Therapy
Cancers (Basel). 2024 Mar 31;16(7):1384. doi: 10.3390/cancers16071384.ABSTRACTProstate cancer is a multi-focal disease that can be treated using surgery, radiation, androgen deprivation, and chemotherapy, depending on its presentation. Standard dose-escalated radiation therapy (RT) in the range of 70-80 Gray (GY) is a standard treatment option for prostate cancer. It could be used at different phases of the disease (e.g., as the only primary treatment when the cancer is confined to the prostate gland, combined with other therapies, or as an adjuvant treatment after surgery). Unfortunately, RT for prostate cancer is associa...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Stepan Orlovskiy Pradeep Kumar Gupta Jeffrey Roman Fernando Arias-Mendoza David S Nelson Cameron J Koch Vivek Narayan Mary E Putt Kavindra Nath Source Type: research
Evaluating Leukocyte Telomere Length and Myeloid-Derived Suppressor Cells as Biomarkers for Prostate Cancer
CONCLUSIONS: Our research has established a correlation between LTL and MDSC in patients undergoing biopsy for prostate cancer. Notably, we observed that individuals with localized prostate cancer tend to have shorter LTL and a higher percentage of M-MDSC prior to their diagnosis. These findings suggest that LTL and M-MDSC could potentially serve as adjunctive biomarkers for the early diagnosis of prostate cancer.PMID:38611064 | DOI:10.3390/cancers16071386 (Source: Cancer Control)
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Haruhiko Wakita Yan Lu Xiaoxu Li Takuro Kobayashi Tsuyoshi Hachiya Hisamitsu Ide Shigeo Horie Source Type: research
Dermoscopy as a Tool for Identifying Potentially Metastatic Thin Melanoma: A Clinical-Dermoscopic and Histopathological Case-Control Study
Cancers (Basel). 2024 Apr 1;16(7):1394. doi: 10.3390/cancers16071394.ABSTRACTDespite being early-stage tumors, thin cutaneous melanomas contribute significantly to mortality and have a rising incidence. A retrospective case-control study was performed to identify clinical-dermoscopic and histopathological variables linked to local and distant metastases in melanomas ≤0.8 mm. Data from 1 January 2000 to 22 June 2022 were analyzed from two Italian skin cancer referral centers. Sixteen patients with ≤0.8 mm melanomas developing metastases were studied compared to controls without metastases over 5 years. Statistical analy...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Vincenzo De Giorgi Flavia Silvestri Giovanni Cecchi Federico Venturi Biancamaria Zuccaro Gabriella Perillo Federica Cosso Vincenza Maio Sara Simi Pietro Antonini Serena Pillozzi Lorenzo Antonuzzo Daniela Massi Laura Doni Source Type: research
Liquid Biopsy for Detection of Pancreaticobiliary Cancers by Functional Enrichment and Immunofluorescent Profiling of Circulating Tumor Cells and Their Clusters
Cancers (Basel). 2024 Apr 2;16(7):1400. doi: 10.3390/cancers16071400.ABSTRACTCirculating tumor cells (CTCs) have historically been used for prognostication in oncology. We evaluate the performance of liquid biopsy CTC assay as a diagnostic tool in suspected pancreaticobiliary cancers (PBC). The assay utilizes functional enrichment of CTCs followed by immunofluorescent profiling of organ-specific markers. The performance of the assay was first evaluated in a multicentric case-control study of blood samples from 360 participants, including 188 PBC cases (pre-biopsy samples) and 172 healthy individuals. A subsequent prospecti...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Andrew Gaya Nitesh Rohatgi Sewanti Limaye Aditya Shreenivas Ramin Ajami Dadasaheb Akolkar Vineet Datta Ajay Srinivasan Darshana Patil Source Type: research
Further Clarification of Pain Management Complexity in Radiotherapy: Insights from Modern Statistical Approaches
CONCLUSIONS: The study underscores the dynamic nature of pain management during RT, suggesting improvements over the treatment course yet revealing specific challenges in non-cancer pain management, particularly among younger breast cancer patients. The use of advanced statistical techniques for analysis stresses the importance of a multifaceted approach to pain management, one that incorporates both cancer and non-cancer pain considerations to ensure a holistic and improved quality of oncological care.PMID:38611085 | DOI:10.3390/cancers16071407 (Source: Cancer Control)
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Costanza Maria Donati Erika Galietta Francesco Cellini Alessia Di Rito Maurizio Portaluri Cristina De Tommaso Anna Santacaterina Consuelo Tamburella Filippo Mammini Rossella Di Franco Salvatore Parisi Sabrina Cossa Antonella Bianculli Pierpaolo Ziccarelli Source Type: research
Real-World Data and Evidence in Lung Cancer: A Review of Recent Developments
Cancers (Basel). 2024 Apr 4;16(7):1414. doi: 10.3390/cancers16071414.ABSTRACTConventional cancer clinical trials can be time-consuming and expensive, often yielding results with limited applicability to real-world scenarios and presenting challenges for patient participation. Real-world data (RWD) studies offer a promising solution to address evidence gaps and provide essential information about the effects of cancer treatments in real-world settings. The distinction between RWD and data derived from randomized clinical trials lies in the method of data collection, as RWD by definition are obtained at the point of care. Ex...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Eleni Kokkotou Maximilian Anagnostakis Georgios Evangelou Nikolaos K Syrigos Ioannis Gkiozos Source Type: research
Polyphenols-Enrichment of Vienna Sausages Using Microcapsules Containing Acidic Aqueous Extract of < em > Boletus edulis < /em > Mushrooms
In conclusion, microcapsules are more suitable for use as a polyphenol enrichment ingredient in Vienna sausages than the extract.PMID:38611285 | DOI:10.3390/foods13070979 (Source: Cancer Control)
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Melinda Fogarasi Maria Jenica Urs Maria-Ioana Socaciu Floricu ța Ranga Cristina Anamaria Semeniuc Dan Cristian Vodnar Vlad Mure șan Dorin Țibulcă Szabolcs Fogarasi Carmen Socaciu Source Type: research
Three-Dimensional Structure of Novel Liver Cancer Biomarker Liver Cancer-Specific Serine Protease Inhibitor Kazal (LC-SPIK) and Its Performance in Clinical Diagnosis of Hepatocellular Carcinoma (HCC)
Diagnostics (Basel). 2024 Mar 29;14(7):725. doi: 10.3390/diagnostics14070725.ABSTRACTLC-SPIK is a liver cancer-specific isoform of Serine Protease Inhibitor Kazal and has been proposed as a new biomarker for the detection of HCC given its unique 3D structure, which differs from normal pancreatic SPIK. An ELISA technology based on its unique structure was developed to use LC-SPIK as an effective biomarker for the clinical diagnosis of HCC. AFP, the most widely used biomarker for HCC surveillance currently, suffers from poor clinical performance, especially in the detection of early-stage HCC. In one case-control study, whic...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Felix Lu Connor Ott Prabha Bista Xuanyong Lu Source Type: research
The Cancer-Protective Potential of Protocatechuic Acid: A Narrative Review
Molecules. 2024 Mar 23;29(7):1439. doi: 10.3390/molecules29071439.ABSTRACTCancer is one of the leading causes of death worldwide, making the search for alternatives for its control a critical issue. In this context, exploring alternatives from natural sources, such as certain vegetables containing a variety of secondary metabolites with beneficial effects on the body and that play a crucial role in the fight against cancer, is essential. Among the compounds with the greatest efficacy in controlling this disease, those with antioxidant activity, particularly phenolic com-pounds, stand out. A remarkable example of this group...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Jorge Cadena-I ñiguez Edelmiro Santiago-Osorio Nancy S ánchez-Flores Sandra Salazar-Aguilar Ram ón Marcos Soto-Hernández Mar ía de la Luz Riviello-Flores V íctor Manuel Macías-Zaragoza Itzen Agui ñiga-Sánchez Source Type: research
Inhibition of Proliferation and Induction of Apoptosis in Prostatic Carcinoma DU145 Cells by Polysaccharides from Yunnan < em > Rosa roxburghii < /em > Tratt
CONCLUSIONS: Rosa roxburghii Tratt polysaccharides, consisting of D-mannose, L-rhamnose, N-acetyl-D-glucosamine, D-galacturonic acid, D-glucose, D-galactcose, D-xylose, L-arabinose, and L-fucose, possess the ability to hinder DU145 cell proliferation, migration, and invasion while inducing apoptosis through the modulation of relevant protein and gene expressions.PMID:38611854 | DOI:10.3390/molecules29071575 (Source: Cancer Control)
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Ziyan Yang Guiyuan Chen Source Type: research
Recent Advances in the Total Synthesis of Spirotryprostatin Alkaloids
Molecules. 2024 Apr 7;29(7):1655. doi: 10.3390/molecules29071655.ABSTRACTSpirotryprostatin alkaloids, a class of alkaloids with a unique spirocyclic indoledionepiperazine structure, were first extracted from the fermentation broth of Aspergillus fumigatus and have garnered significant attention in the fields of biology and pharmacology. The investigation into the pharmacological potential of this class of alkaloids has unveiled promising applications in drug discovery and development. Notably, certain spirotryprostatin alkaloids have demonstrated remarkable anti-cancer activity, positioning them as potential candidates for...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Jing Hu Zhen-Xi Niu Jun-Feng Wang Source Type: research
Multiomics-Based Feature Extraction and Selection for the Prediction of Lung Cancer Survival
Int J Mol Sci. 2024 Mar 25;25(7):3661. doi: 10.3390/ijms25073661.ABSTRACTLung cancer is a global health challenge, hindered by delayed diagnosis and the disease's complex molecular landscape. Accurate patient survival prediction is critical, motivating the exploration of various -omics datasets using machine learning methods. Leveraging multi-omics data, this study seeks to enhance the accuracy of survival prediction by proposing new feature extraction techniques combined with unbiased feature selection. Two lung adenocarcinoma multi-omics datasets, originating from the TCGA and CPTAC-3 projects, were employed for this pur...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Roman Jaksik Kamila Szuma ła Khanh Ngoc Dinh Jaros ław Śmieja Source Type: research
Specific IgE and Basophil Activation Test by Microarray: A Promising Tool for Diagnosis of Platinum Compound Hypersensitivity Reactions
This study aimed to evaluate the usefulness of the basophil activation test by flow cytometry (BAT-FC) and the newly developed sIgE-microarray and BAT-microarray in diagnosing IgE-mediated hypersensitivity reactions to PCs. A total of 24 patients with DHRs to PCs (20 oxaliplatin and four carboplatin) were evaluated: thirteen patients were diagnosed as allergic with positive skin tests (STs) or drug provocation tests (DPTs), six patients were diagnosed as non-allergic with negative STs and DPTs, and five patients were classified as suspected allergic because DPTs could not be performed. In addition, four carboplatin-toleran...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Carlos Fern ández-Lozano Claudia Geraldine Rita Alicia Barra-Castro Bel én de la Hoz Caballer Ernesto Rold án Cristina Pueyo L ópez Javier Martinez-Botas Mar ía Pilar Berges-Gimeno Source Type: research
Dichotomous Effects of Glypican-4 on Cancer Progression and Its Crosstalk with Oncogenes
Int J Mol Sci. 2024 Apr 2;25(7):3945. doi: 10.3390/ijms25073945.ABSTRACTGlypicans are linked to various aspects of neoplastic behavior, and their therapeutic value has been proposed in different cancers. Here, we have systematically assessed the impact of GPC4 on cancer progression through functional genomics and transcriptomic analyses across a broad range of cancers. Survival analysis using TCGA cancer patient data reveals divergent effects of GPC4 expression across various cancer types, revealing elevated GPC4 expression levels to be associated with both poor and favorable prognoses in a cancer-dependent manner. Detaile...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Victor Ch érouvrier Hansson Fang Cheng Grigorios Georgolopoulos Katrin Mani Source Type: research
LDL Receptor-Related Protein 1B Polymorphisms Associated with Increased Risk of Lymph Node Metastasis in Oral Cancer Group with Diabetes Mellitus
Int J Mol Sci. 2024 Apr 2;25(7):3963. doi: 10.3390/ijms25073963.ABSTRACTOral cancer ranks fourth among malignancies among Taiwanese men and is the eighth most common cancer among men worldwide in terms of general diagnosis. The purpose of the current study was to investigate how low-density lipoprotein receptor-related protein 1B (LDL receptor related protein 1B; LRP1B) gene polymorphisms affect oral squamous cell carcinoma (OSCC) risk and progression in individuals with diabetes mellitus (DM). Three LRP1B single-nucleotide polymorphisms (SNPs), including rs10496915, rs431809, and rs6742944, were evaluated in 311 OSCC case...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Liang-Cheng Chen Yu-Sheng Lo Hsin-Yu Ho Chia-Chieh Lin Yi-Ching Chuang Wei-Chen Chang Ming-Ju Hsieh Source Type: research
