Effects of Improper Mechanical Force on the Production of Sonic Hedgehog, RANKL, and IL-6 in Human Periodontal Ligament Cells In Vitro
In this study, we investigated the relationships between Shh, RANKL, and IL-6 in human periodontal ligament (hPDL) cells exposed to improper mechanical force. Weights were placed on hPDL cells and human gingival fibroblasts (HGFs) for an optimal orthodontic force group (1.0 g/cm2) and a heavy orthodontic force group (4.0 g/cm2). A group with no orthodontic force was used as a control group. Real-time PCR, SDS-PAGE, and Western blotting were performed to examine the effects of orthodontic forces on the expression of Shh, RANKL, and IL-6 at 2, 4, 6, 8, 12, and 24 h after the addition of pressure. The protein expression of Sh...
Source: Cancer Control - April 26, 2024 Category: Cancer & Oncology Authors: Erika Yamashita Shinichi Negishi Jun Kikuta Mami Shimizu Hidenobu Senpuku Source Type: research
Application of Multi-Criteria Decision Analysis (MCDA) to Prioritize Real-World Evidence Studies for Health Technology Management: Outcomes and Lessons Learned by the Canadian Real-World Evidence for Value of Cancer Drugs (CanREValue) Collaboration
Curr Oncol. 2024 Apr 1;31(4):1876-1898. doi: 10.3390/curroncol31040141.ABSTRACTMulti-criteria decision analysis (MCDA) is a value assessment tool designed to help support complex decision-making by incorporating multiple factors and perspectives in a transparent, structured approach. We developed an MCDA rating tool, consisting of seven criteria evaluating the importance and feasibility of conducting potential real-world evidence (RWE) studies aimed at addressing uncertainties stemming from initial cancer drug funding recommendations. In collaboration with the Canadian Agency for Drugs and Technologies in Health's Provinci...
Source: Cancer Control - April 26, 2024 Category: Cancer & Oncology Authors: Pam Takhar Marc Geirnaert Scott Gavura Jaclyn Beca Rebecca E Mercer Avram Denburg Caroline Mu ñoz Mina Tadrous Ambica Parmar Francois Dionne Darryl Boehm Carole Chambers Erica Craig Maureen Trudeau Matthew C Cheung Joanne Houlihan Valerie McDonald Petros Source Type: research
Prehabilitation in Adults Undergoing Cancer Surgery: A Comprehensive Review on Rationale, Methodology, and Measures of Effectiveness
Curr Oncol. 2024 Apr 9;31(4):2185-2200. doi: 10.3390/curroncol31040162.ABSTRACTCancer surgery places a significant burden on a patients' functional status and quality of life. In addition, cancer surgery is fraught with postoperative complications, themselves influenced by a patient's functional status. Prehabilitation is a unimodal or multimodal strategy that aims to increase a patient's functional capacity to reduce postoperative complications and improve postoperative recovery and quality of life. In most cases, it involves exercise, nutrition, and anxiety-reducing interventions. The impact of prehabilitation has been e...
Source: Cancer Control - April 26, 2024 Category: Cancer & Oncology Authors: Carlos E Guerra-Londono Juan P Cata Katherine Nowak Vijaya Gottumukkala Source Type: research
Gastro-Intestinal Symptoms in Palliative Care Patients
Curr Oncol. 2024 Apr 21;31(4):2341-2352. doi: 10.3390/curroncol31040174.ABSTRACTThis review of the palliation of various gastro-intestinal (GI) symptoms encountered in cancer patients is by no means exhaustive. Frequent symptoms such as constipation, nausea and vomiting, bowel obstructions, ascites and bleeds will be discussed, focusing on their assessment and most importantly, how to control the associated symptoms. All of these symptoms and GI complications can significantly impact patients' quality of life (QOL) and should be treated as quickly and aggressively as possible.PMID:38668077 | DOI:10.3390/curroncol31040174 (...
Source: Cancer Control - April 26, 2024 Category: Cancer & Oncology Authors: Golda Elisa Tradounsky Source Type: research
NOD2 Responds to Dengue Virus Type 2 Infection in Macrophage-like Cells Interacting with MAVS Adaptor and Affecting IFN- α Production and Virus Titers
Pathogens. 2024 Apr 10;13(4):306. doi: 10.3390/pathogens13040306.ABSTRACTIn pathogen recognition, the nucleotide-binding domain (NBD) and leucine rich repeat receptors (NLRs) have noteworthy functions in the activation of the innate immune response. These receptors respond to several viral infections, among them NOD2, a very dynamic NLR, whose role in dengue virus (DENV) infection remains unclear. This research aimed to determine the role of human NOD2 in THP-1 macrophage-like cells during DENV-2 infection. NOD2 levels in DENV-2 infected THP-1 macrophage-like cells was evaluated by RT-PCR and Western blot, and an increase ...
Source: Cancer Control - April 26, 2024 Category: Cancer & Oncology Authors: Diana Alhel í Domínguez-Martínez Mayra Silvia P érez-Flores Daniel N úñez-Avellaneda Jes ús M Torres-Flores Gloria Le ón-Avila Blanca Estela Garc ía-Pérez Ma Isabel Salazar Source Type: research
Biomarkers in Detection of Hepatitis C Virus Infection
Pathogens. 2024 Apr 17;13(4):331. doi: 10.3390/pathogens13040331.ABSTRACTThe hepatitis C virus (HCV) infection affects 58 million people worldwide. In the United States, the incidence rate of acute hepatitis C has doubled since 2014; during 2021, this increased to 5% from 2020. Acute hepatitis C is defined by any symptom of acute viral hepatitis plus either jaundice or elevated serum alanine aminotransferase (ALT) activity with the detection of HCV RNA, the anti-HCV antibody, or hepatitis C virus antigen(s). However, most patients with acute infection are asymptomatic. In addition, ALT activity and HCV RNA levels can fluct...
Source: Cancer Control - April 26, 2024 Category: Cancer & Oncology Authors: Jungreem Woo Youkyung Choi Source Type: research
A Comparative Analysis of Polysaccharides and Ethanolic Extracts from Two Egyptian Sweet Potato Cultivars, Abees and A 195: Chemical Characterization and Immunostimulant Activities
In conclusion, the roots of the Egyptian sweet potato cultivars Abees and A 195 demonstrated significant immunostimulant activities, which warrants further investigation through clinical studies.PMID:38668350 | DOI:10.3390/metabo14040222 (Source: Cancer Control)
Source: Cancer Control - April 26, 2024 Category: Cancer & Oncology Authors: Rehab M Elgabry Mariam Hassan Ghada A Fawzy Khaled M Meselhy Osama G Mohamed Areej M Al-Taweel Mohamed S Sedeek Source Type: research
Decreased Ubiquitination and Acetylation of Histones 3 and 4 Are Associated with Obesity-Induced Disorders of Spermatogenesis in Mice
CONCLUSION: These results suggest that low levels of histone ubiquitination and acetylation are linked with obesity-induced disorders during spermatogenesis, contributing to a better understanding of obesity-induced damage to male reproduction.PMID:38668519 | DOI:10.3390/toxics12040296 (Source: Cancer Control)
Source: Cancer Control - April 26, 2024 Category: Cancer & Oncology Authors: Mahamadou Fofana Zhenyang Li Han Li Wenqi Li Lu Wu Lu Lu Qizhan Liu Source Type: research
Nanoparticle Polymeric Micellar Paclitaxel Versus Paclitaxel for Patients with Advanced Gastric Cancer
CONCLUSIONS: NPMP combined chemotherapy offers a new, active, and safe treatment for patients with AGC.PMID:38668776 | DOI:10.1007/s12029-024-01058-y (Source: Cancer Control)
Source: Cancer Control - April 26, 2024 Category: Cancer & Oncology Authors: Fei-Yu Wang Xiang-Ming Huang Yu-Qing Cao Jie Cao Jie Ni Ke Li Min Lu Xin-En Huang Source Type: research
Emerging From the Haze ™: Pilot Feasibility Study Comparing Two Virtual Formats of a Cognitive Rehabilitation Intervention
Oncol Nurs Forum. 2024 Apr 18;51(3):223-242. doi: 10.1188/24.ONF.223-242.ABSTRACTOBJECTIVES: To gather feasibility and preliminary data comparing two virtual delivery methods for providing Emerging From the Haze™ (Haze) to cancer survivors compared to waitlist control (WLC).SAMPLE & SETTING: Eligible participants (N = 93) reported cancer-related cognitive impairment following chemotherapy for stage I-III solid tumors, Hodgkin lymphoma, or non-Hodgkin lymphoma.METHODS & VARIABLES: A three-arm randomized design was used to compare virtual live group presentation of Haze sessions, virtual prerecorded Haze group sess...
Source: Cancer Control - April 26, 2024 Category: Cancer & Oncology Authors: Jamie S Myers Jeffrey C Wertheimer Jaromme Geebum Kim Jianghua He Celina H Shirazipour Dedrick Hooper Mary Penne Mays Jennifer R Klemp Carli Zegers Arash Asher Source Type: research
Efficacy and safety of chemoimmunotherapy in advanced non-small cell lung cancer patients with antibiotics-induced dysbiosis: a propensity-matched real-world analysis
CONCLUSION: Antibiotic-induced dysbiosis may not affect the efficacy of chemo-IOs in patients with advanced NSCLC.PMID:38668936 | DOI:10.1007/s00432-024-05649-x (Source: Cancer Control)
Source: Cancer Control - April 26, 2024 Category: Cancer & Oncology Authors: Kentaro Tamura Yusuke Okuma Shogo Nomura Akito Fukuda Ken Masuda Yuji Matsumoto Yuki Shinno Tatsuya Yoshida Yasushi Goto Hidehito Horinouchi Noboru Yamamoto Yuichiro Ohe Source Type: research
Endometrioid Endometrial RNA Index Predicts Recurrence in Stage I Patients
CONCLUSIONS: Tumors with high-risk genetic features may require additional treatment or closer monitoring and are not readily identified using traditional clinicopathologic and molecular features. EERI performs with high sensitivity and modest specificity, which may benefit from further optimization and validation in larger independent cohorts.PMID:38669067 | DOI:10.1158/1078-0432.CCR-23-3158 (Source: Cancer Control)
Source: Cancer Control - April 26, 2024 Category: Cancer & Oncology Authors: Corrine A Nief Phoebe M Hammer Aihui Wang Vivek Charu Amina Tanweer Babak Litkouhi Elizabeth Kidd Andrew J Gentles Brooke E Howitt Source Type: research
Growing the global cancer care system: success stories from around the world and lessons for the future
J Natl Cancer Inst. 2024 Apr 25:djae087. doi: 10.1093/jnci/djae087. Online ahead of print.ABSTRACTDespite significant biomedical advancements in various realms of oncology, the benefits of these developments are not equitably distributed, particularly in under-resourced settings. While much work has described the challenges and systemic barriers in global cancer control, in this essay we focus on success stories. This piece describes clinical care delivered at Rwanda's Butaro Cancer Center of Excellence, the cancer research collaborations under India's National Cancer Grid, and the efforts of Latin America's Institute of C...
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Edward Christopher Dee C S Pramesh Christopher M Booth Fidel Rubagumya Miriam Mutebi Erin Jay G Feliciano Michelle Ann B Eala Giovanni G Cerri Ophira Ginsburg Bishal Gyawali Fabio Ynoe de Moraes Source Type: research
Severe acute myositis and myocarditis on initiation of 6-weekly pembrolizumab post-COVID-19 mRNA vaccination
In conclusion, we report a series of unusually severe myositis and myocarditis following PD-1 blockade and the COVID-19 mRNA vaccination.PMID:38663935 | DOI:10.1136/jitc-2023-008151 (Source: Cancer Control)
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Robert A Watson Weiyu Ye Chelsea A Taylor Elsita Jungkurth Rosalin Cooper Orion Tong Tim James Brian Shine Monika Hofer Damian Jenkins Robert Pell Eleni Ieremia Stephanie Jones David Maldonado-Perez Ian S D Roberts Nicholas Coupe Mark R Middleton Miranda Source Type: research
Randomized Trial of Prostate-Specific Membrane Antigen PET/CT Before Definitive Radiotherapy for Unfavorable Intermediate- and High-Risk Prostate Cancer (PSMA-dRT Trial)
Conclusion: PSMA PET/CT upstaged 17% of patients, which allowed for more accurate radiotherapy planning. Unfortunately, this trial closed early before completion of target enrollment (54/316, 17%) and was underpowered to assess the effect of PSMA PET/CT on progression-free survival.PMID:38664019 | DOI:10.2967/jnumed.123.267004 (Source: Cancer Control)
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: John Nikitas Ethan Lam Kiara Adame Booker Wolfgang P Fendler Matthias Eiber Boris Hadaschik Ken Herrmann Nader Hirmas Helena Lanzafame Martin Stuschke Johannes Czernin Michael L Steinberg Nicholas G Nickols Amar U Kishan Jeremie Calais Source Type: research
