The rationale behind grafting haploidentical hematopoietic stem cells
Hematology. 2024 Dec;29(1):2347673. doi: 10.1080/16078454.2024.2347673. Epub 2024 May 7.ABSTRACTThe ability to perform hematopoietic cell transplant across major histocompatibility complex barriers can dramatically increase the availability of donors and allow more patients across the world to pursue curative transplant procedures for underlying hematologic disorders. Early attempts at haploidentical transplantation using broadly reactive T-cell depletion approaches were compromised by graft rejection, graft-versus-host disease and prolonged immune deficiency. The evolution of haploidentical transplantation focused on expa...
Source: Cancer Control - May 7, 2024 Category: Cancer & Oncology Authors: Richard T Maziarz Rachel J Cook Source Type: research
Study of antitumor effects of human placenta hydrolysate on PC-3, OAW-42, BT-474 cell cultures
CONCLUSION: The results of the study indicate not only the oncological safety of the HPH used in therapy but also the mild antitumor effects of this HPH at high concentrations.PMID:38713042 | DOI:10.26442/00403660.2024.03.202624 (Source: Cancer Control)
Source: Cancer Control - May 7, 2024 Category: Cancer & Oncology Authors: O A Gromova M V Filimonova I Y Torshin D Е Frolova Source Type: research
Pegvisomant or pasirotide in PRL and GH co-secreting vs GH-secreting Pit-NETs
CONCLUSION: Despite the more aggressive behavior of GH/PRL-Pit-NETs than GH-Pit-NETs, no differences in the rate of IGF-1 control with pegvisomant and pasireotide is observed between both groups, and both drugs are effective treatments to control IGF-1 and PRL hypersecretion in these tumors.PMID:38713182 | DOI:10.1530/ERC-24-0043 (Source: Cancer Control)
Source: Cancer Control - May 7, 2024 Category: Cancer & Oncology Authors: Marta Araujo-Castro Betina Biagetti Edelmiro Menedez-Torre Ir ía Novoa-Testa Fernando Cordido Eider Pascual-Corrales V íctor Rodríguez Berrocal Fernando Guerrero-P érez Almudena Vicente Juan Carlos Percovich Hualpa Rogelio Garcia Centeno Laura Gonz á Source Type: research
Conformation-Switchable Polypeptides as Molecular Gates for Controllable Drug Release
This study highlights the important role of chain flexibility in modulating the biological function of polypeptides and provides a new application paradigm for synthetic polypeptides with secondary-structure transition.PMID:38713187 | DOI:10.1021/acs.biomac.4c00024 (Source: Cancer Control)
Source: Cancer Control - May 7, 2024 Category: Cancer & Oncology Authors: Chenglong Ge Jianyin He Mudan Gan Yu Qian Junliang Zhu Fan Wu Ziyuan Song Lichen Yin Source Type: research
From ownership to custodianship of tumor biopsy tissue in genomic testing: a mixed methods study of patient views
Oncologist. 2024 May 7:oyae074. doi: 10.1093/oncolo/oyae074. Online ahead of print.ABSTRACTTumor mutation profiling (MP) is often conducted on tissue from biopsies conducted for clinical purposes (diagnostic tissue). We aimed to explore the views of patients with cancer on who should own tumor biopsy tissue, pay for its storage, and decide on its future use; and determine their attitudes to and predictors of undergoing additional biopsies if required for research purposes. In this mixed methods, cross-sectional study, patients with advanced solid cancers enrolled in the Molecular Screening and Therapeutics Program (n = 397...
Source: Cancer Control - May 7, 2024 Category: Cancer & Oncology Authors: Megan C Best Phyllis Butow Jacqueline Savard Ainsley J Newson Rachel Campbell Sabina Vatter Christine E Napier Nicci Bartley Katherine Tucker Mandy L Ballinger David M Thomas PiGeOn Project Source Type: research
Identifying risk factors for hypoxemia during emergence from anesthesia in patients undergoing robot-assisted laparoscopic radical prostatectomy
This study aims to identify risk factors related to hypoxemia during the emergence from anesthesia in patients undergoing RALP. A cohort of 316 patients undergoing RALP was divided into two groups: the hypoxemia group (N = 134) and the non-hypoxemia group (N = 182), based on their postoperative oxygen fraction. Comprehensive data were collected from the hospital information system, including preoperative baseline parameters, intraoperative data, and postoperative recovery profiles. Risk factors were examined using multiple logistic regression analysis. The study showed that 38.9% of patients had low preoperative partial pr...
Source: Cancer Control - May 7, 2024 Category: Cancer & Oncology Authors: Qiyao Zhang Leilei Zhu Shengjie Yuan Shunmei Lu Xin Zhang Source Type: research
Acupuncture for the treatment of the pain-fatigue-sleep disturbance-numbness/tingling symptom cluster in breast cancer survivors: a feasibility trial
CONCLUSION: This study demonstrated that acupuncture was safe and feasible, justifying a powered randomized control trial. Preliminary findings suggest beneficial effects of acupuncture for the management of the pain-fatigue-sleep disturbance-numbness/tingling symptom cluster for women with breast cancer. TCM syndromes identified in this trial may be used to guide acupuncture treatment protocols.CLINICAL TRIAL REGISTRATION: This trial was registered with the Australian New Zealand Clinical Trials Registry (ACTRN12622000590763) on 21 April 2022.PMID:38713422 | DOI:10.1007/s00520-024-08529-9 (Source: Cancer Control)
Source: Cancer Control - May 7, 2024 Category: Cancer & Oncology Authors: Ki Kyung Kwon Judith Lacey Kim Kerin-Ayres Gillian Heller Suzanne Grant Source Type: research
Application of PLK1 and HOXA13 Gene Expression Levels in Urine in the Diagnosis of Non-muscle Invasive Bladder Cancer
This study aimed to develop an accurate and non-invasive urine-based gene expression assay, including fibroblast growth factor receptor 3 (FGFR3), homeobox A13 (HOXA13), and polo-like kinase 1 (PLK1), to diagnose non-muscle-invasive bladder cancer (NMIBC) at stages Ta and T1. The samples were acquired from 62 patients with NMIBC, 31 control individuals, and 31 patients with non-cancerous genitourinary tract diseases. The expression levels of three relevant genes were determined using quantitative RT-PCR. In addition, the sensitivity and specificity of the data for these genes were computed. Our results showed that PLK1, HO...
Source: Cancer Control - May 7, 2024 Category: Cancer & Oncology Authors: Sahar Valizadeh Sana Taghiyar Serajedin Vahidi Omid Abazari Mahmood Akhavan Tafti Javad Zavar Reza Source Type: research
Multilevel Characteristics of Cumulative Symptom Burden in Young Survivors of Childhood Cancer
CONCLUSIONS AND RELEVANCE: In this cross-sectional study of young childhood cancer survivors, symptom burden was prevalent. Caregiver anxiety and disparity-related neighborhood factors were associated with greater symptom burden, whereas meaning and purpose was a protective factor. Greater specific symptom burden contributed to poorer HRQOL. The findings suggest that interventions targeting resilience and neighborhood adversity may alleviate symptom burden and improve HRQOL.PMID:38713463 | DOI:10.1001/jamanetworkopen.2024.10145 (Source: Cancer Control)
Source: Cancer Control - May 7, 2024 Category: Cancer & Oncology Authors: Madeline R Horan Deo Kumar Srivastava Jaesung Choi Kevin R Krull Gregory T Armstrong Kirsten K Ness Melissa M Hudson Justin N Baker I-Chan Huang Source Type: research
Non-TGF β profibrotic signaling in ulcerative colitis after < em > in vivo < /em > experimental intestinal injury in humans
In conclusion, we found distinct regulatory layers of regeneration in the normal human colon and a potential targetable profibrotic dysregulation in UC that could lead to long-term end organ failure - i.e., intestinal damage.PMID:38713614 | DOI:10.1152/ajpgi.00074.2024 (Source: Cancer Control)
Source: Cancer Control - May 7, 2024 Category: Cancer & Oncology Authors: Jakob B Seidelin Mariana Bronze Anja Poulsen Mohamed Attauabi Anders Woetmann Benjamin E Mead Jeffrey M Karp Lene B Riis Jacob T Bjerrum Source Type: research
Cholesterol uptake in the intestine is regulated by the LASP1-AKT-NPC1L1 signaling pathway
Am J Physiol Gastrointest Liver Physiol. 2024 May 7. doi: 10.1152/ajpgi.00222.2023. Online ahead of print.ABSTRACTCholesterol is essential for the stability and architecture of the plasma membrane and a precursor of bile acids and steroid hormones in mammals. Excess dietary cholesterol uptake leads to hypercholesterolaemia, atherosclerosis and plays a role in cancer development. The role of actin-binding scaffolding protein LIM and SH3 protein 1 (LASP1) in cholesterol trafficking has not been investigated previously. Cholesterol levels, its uptake and excretion were studied in mice deficient for low density lipoprotein rec...
Source: Cancer Control - May 7, 2024 Category: Cancer & Oncology Authors: Elke Butt Thorsten Guender Paulina Stuerzebecher Isabel Kowalski Pia Schneider Nils Buschmann Sarah Sch äfer Alicia Bender Heike M Hermanns Alma Zernecke Source Type: research
Effective and Successful Control of Symptomatic Vertebral Hemangiomas With Epidural Extension Using Stereotactic Spine Radiosurgery
CONCLUSION: To our knowledge, this represents the largest series of SVHEE patients treated with SSRS, either as monotherapy or part of a multimodal/separation surgery treatment approach. We demonstrate that SSRS represents a potentially safe and effective treatment option in these patients. However, larger prospective studies and longer follow-ups are necessary to further assess the role, durability, and toxicity of SSRS in the management of these patients.PMID:38713900 | DOI:10.1227/neu.0000000000002947 (Source: Cancer Control)
Source: Cancer Control - May 7, 2024 Category: Cancer & Oncology Authors: Arpan A Patel Daniel Lilly Samuel T Chao Edward Benzel Gandhivarma Subramaniam Ajit Krishnaney John H Suh Lilyana Angelov Source Type: research
Impact of interventions to improve HPV vaccination acceptance and uptake in school-based programs: Findings of a pilot project in Quebec
CONCLUSION: Although school-based programs offer equitable access to vaccination and minimize access barriers, it remains crucial to identify effective interventions to improve vaccine uptake further and reach the WHO cervical cancer elimination goal. Our multicomponent strategy appears to have positively impacted HPV vaccine acceptability and coverage and could be adapted to other contexts where vaccination is delivered in school-based programs.PMID:38714451 | DOI:10.1016/j.vaccine.2024.04.089 (Source: Cancer Control)
Source: Cancer Control - May 7, 2024 Category: Cancer & Oncology Authors: Maude Dionne Doriane Étienne Holly O Witteman Chantal Sauvageau Ève Dubé Source Type: research
Lifetime prevalence and correlates of colorectal cancer screening among low-income U.S. Veterans
CONCLUSION: Nearly 55% of low-income U.S. Veterans reported ever screening for CRC. Variations in CRC-screening behaviors according to veteran characteristics highlight potential disparities as well as opportunities for targeted behavioral interventions.PMID:38714606 | DOI:10.1007/s10552-024-01881-5 (Source: Cancer Control)
Source: Cancer Control - May 7, 2024 Category: Cancer & Oncology Authors: Hind A Beydoun Jack Tsai Source Type: research
Comparative effectiveness of remote digital gamified and group CBT skills training interventions for anxiety and depression among college students: Results of a three-arm randomised controlled trial
Behav Res Ther. 2024 May 3;178:104554. doi: 10.1016/j.brat.2024.104554. Online ahead of print.ABSTRACTDigital interventions can enhance access to healthcare in under-resourced settings. However, guided digital interventions may be costly for low- and middle-income countries, despite their effectiveness. In this randomised control trial, we evaluated the effectiveness of two digital interventions designed to address this issue: (1) a Cognitive Behavioral Therapy Skills Training (CST) intervention that increased scalability by using remote online group administration; and (2) the SuperBetter gamified self-guided CBT skills t...
Source: Cancer Control - May 7, 2024 Category: Cancer & Oncology Authors: Jason Bantjes Xanthe Hunt Pim Cuijpers Alan E Kazdin Chris J Kennedy Alex Luedtke Ivana Malenica Maria Petukhova Nancy Sampson Nur Hani Zainal Charl Davids Munita Dunn-Coetzee Rone Gerber Dan J Stein Ronald C Kessler Source Type: research
