Analysis of Molecular Genetic Variants of Lgals4 in Esophageal Cancer: A Preliminary Report
Biochem Genet. 2024 Apr 12. doi: 10.1007/s10528-024-10780-y. Online ahead of print.ABSTRACTEsophageal cancer is the eighth most common cancer worldwide and fourth most common in developing countries. Altered glycosylation pattern of cell membrane molecules along with inflammation is a characteristic attribute of oncogenesis. Galectin-4, a tandem repeat galectin, has shown effect on cancer progression/metastasis in digestive system cancers. This role of galectin-4 can be attributed to variations in LGALS4, gene encoding galectin-4. The present case-control study was designed to analyze four intronic SNPs in LGALS4 with susc...
Source: Cancer Control - April 11, 2024 Category: Cancer & Oncology Authors: Surmeet Kaur Rajiv Devgan Jagdeep Singh Namarta Kalia Jatinder Singh Manpreet Kaur Source Type: research
Exploring the relationship between Treg-mediated risk in COPD and lung cancer through Mendelian randomization analysis and scRNA-seq data integration
BMC Cancer. 2024 Apr 11;24(1):453. doi: 10.1186/s12885-024-12076-1.ABSTRACTBACKGROUND: Evidence from observational studies suggests an association between chronic obstructive pulmonary disease (COPD) and lung cancer. The potential interactions between the immune system and the lungs may play a causative role in COPD and lung cancer and offer therapeutic prospects. However, the causal association and the immune-mediated mechanisms between COPD and lung cancer remain to be determined.METHODS: We employed a two-sample Mendelian randomization (MR) approach to investigate the causal association between COPD and lung cancer. Add...
Source: Cancer Control - April 11, 2024 Category: Cancer & Oncology Authors: Dengfeng Zhang Haitao Liu Fangchao Zhao Pengfei Guo Jing Li Tianxing Lu Zhirong Li Shujun Li Source Type: research
Biomarkers of lipid metabolism in gastric cancer: a case control study
CONCLUSIONS: The serum lipid level of gastric cancer patients was higher than healthy controls. HDL-C and LDL-C abnormal correlated with gastric cancer risk. However, as the progresses of gastric cancer, poor patient intake, increased tumor consumption, and continuous declining in nutritional status, the levels of TC and TG gradually decreased in advanced gastric cancer.PMID:38605344 | DOI:10.1186/s12885-024-12230-9 (Source: Cancer Control)
Source: Cancer Control - April 11, 2024 Category: Cancer & Oncology Authors: Fangxuan Li Jinli Dou Lijuan Wei Shixia Li Juntian Liu Source Type: research
Do beta-blockers reduce negative intrusive thoughts and anxiety in cancer survivors? - An emulated trial
CONCLUSIONS: The emulated trials demonstrated no evidence of a protective effect of beta-blocker therapy against intrusive thoughts. The Active group had reduced quality of life and elevated anxiety compared to the Control group.TRIAL REGISTRATION: The three cohort studies were registered at isrctn.com/clinicaltrials.gov (ISRCTN06393679, NCT02530593 and NCT01477229).PMID:38605350 | DOI:10.1186/s12885-024-12236-3 (Source: Cancer Control)
Source: Cancer Control - April 11, 2024 Category: Cancer & Oncology Authors: Carolina Ehrencrona Ying Li Eva Angenete Eva Haglind Stefan Franz én Anna Grimby-Ekman David Bock Source Type: research
Assessment of disease control rate and safety of sorafenib in targeted therapy for advanced liver cancer
CONCLUSION: SMTT had demonstrated good efficacy in patients with ALC, improving the DCR, enhancing the immune response of the body, and reducing the incidence of ARs, thereby promoting the disease outcome. Therefore, it was a treatment method worthy of promotion and application.PMID:38605359 | DOI:10.1186/s12957-024-03364-y (Source: Cancer Control)
Source: Cancer Control - April 11, 2024 Category: Cancer & Oncology Authors: Daolin Zeng Chunlin Yu Shiyao Chen Long Zou Junjun Chen Linlong Xu Source Type: research
Occupational exposure to organic solvents and the risk of developing testicular germ cell tumors (TESTIS study): Effect of combined exposure assessment on risk estimation
CONCLUSION: The results suggest that some organic solvents might be involved in the pathogenesis of TGCT among occupationally exposed men. The combined use of JEM+SQ+EA seemed to limit misclassification by considering individual exposure variability and is, therefore, an appealing approach to assess occupational exposures in epidemiological studies.PMID:38597023 | DOI:10.5271/sjweh.4161 (Source: Cancer Control)
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Margot Guth Corinne Pilorget Marie Lefevre Astrid Coste Aur élie Danjou Brigitte Dananch é Delphine Praud Olivia P érol Myriam Daudin Marie-Ange Clarotti St éphanie Lattes C éline Bouillon Ad èle Paul Joachim Sch üz Louis Bujan Ann Olsson B éatric Source Type: research
Thoracic skeletal muscle mass predicts mortality in patients with surgery for pleural empyema: A case control study
CONCLUSIONS: TSMI was a significant prognostic risk factor for postoperative mortality in patients with pleural empyema. TSMI may be suitable for risk stratification in this disease with high morbidity and mortality, which may have further implications for the selection of the best treatment strategy.PMID:38597111 | DOI:10.1111/1759-7714.15307 (Source: Cancer Control)
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Christian Galata Philipp Schiller Lukas M üller Ioannis Karampinis Davor Stamenovic Roland Buhl Michael Kreuter Eric Dominic Roessner Source Type: research
Midwife continuity of care models versus other models of care for childbearing women
CONCLUSIONS: Women receiving midwife continuity of care models were less likely to experience a caesarean section and instrumental birth, and may be less likely to experience episiotomy. They were more likely to experience spontaneous vaginal birth and report a positive experience. The certainty of some findings varies due to possible risks of bias, inconsistencies, and imprecision of some estimates. Future research should focus on the impact on women with social risk factors, and those at higher risk of complications, and implementation and scaling up of midwife continuity of care models, with emphasis on low- and middle-...
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Jane Sandall Cristina Fernandez Turienzo Declan Devane Hora Soltani Paddy Gillespie Simon Gates Leanne V Jones Andrew H Shennan Hannah Rayment-Jones Source Type: research
Chidamide plus envafolimab as subsequent treatment in advanced non-small cell lung cancer patients resistant to anti-PD-1 therapy: A multicohort, open-label, phase II trial with biomarker analysis
CONCLUSION: Combination of chidamide and envafolimab showed efficacy signals in certain NSCLC patients. But further identification of beneficial population is necessary for precision treatment.PMID:38597130 | DOI:10.1002/cam4.7175 (Source: Cancer Control)
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Yaxiong Zhang Zihong Chen Yu Liu Liang Han Wei Jiang Qiming Wang Jianhua Shi Liqin Lu Jianying Li Mingjun Zhang Yan Huang Yunpeng Yang Xue Hou Li Zhang Jing Li Wenfeng Fang Gang Chen Source Type: research
What is the relationship between the local population change and cancer incidence in patients with dyslipidemia: Evidence of the impact of local extinction in Korea
CONCLUSION: Patients in regions where the population has declined are at a higher risk of cancer, highlighting the importance of managing medical problems caused by regional extinction. This could provide evidence for and useful insights into official policies on population decline and cancer risk.PMID:38597133 | DOI:10.1002/cam4.7169 (Source: Cancer Control)
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Wonjeong Jeong Dong-Woo Choi Woorim Kim Kyu-Tae Han Source Type: research
The safety, feasibility and oncological outcomes of laparoscopic completion total gastrectomy for remnant gastric cancer: a prospective study with 3-year follow-up (FUGES-004 study)
CONCLUSIONS: This prospective study suggested that LCTG was non-inferior to OCTG in both short- and long-term outcomes. In experienced centers, LCTG may be considered as a viable treatment option for RGC.PMID:38597388 | DOI:10.1097/JS9.0000000000001388 (Source: Cancer Control)
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Qing Zhong Dong Wu Yiming Jiang Qing-Liang He Xue-Yi Dang Dong-Bo Xu Yuqin Sun Guo-Qiang Su Kai-Qing Guo Li-Sheng Cai Haoxiang Zhang Wen Ye Guangtan Lin Ping Li Jian-Wei Xie Qi-Yue Chen Chao-Hui Zheng Jun Lu Chang-Ming Huang Jian-Xian Lin Source Type: research
KIS counteracts PTBP2 and regulates alternative exon usage in neurons
Elife. 2024 Apr 10;13:e96048. doi: 10.7554/eLife.96048. Online ahead of print.ABSTRACTAlternative RNA splicing is an essential and dynamic process in neuronal differentiation and synapse maturation, and dysregulation of this process has been associated with neurodegenerative diseases. Recent studies have revealed the importance of RNA-binding proteins in the regulation of neuronal splicing programs. However, the molecular mechanisms involved in the control of these splicing regulators are still unclear. Here we show that KIS, a kinase upregulated in the developmental brain, imposes a genome-wide alteration in exon usage du...
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Marcos Moreno-Aguilera Alba M Neher M ónica B Mendoza Martin Dodel Faraz K Mardakheh Ra úl Ortiz Carme Gallego Source Type: research
Thermal ablation with and without adjuvant systemic therapy: a nationwide multicenter observational cohort study of solitary colorectal liver metastases
CONCLUSIONS: For patients with plasma CEA >5 ug/L, T (III-IV) category of primary cancer, or clinical risk score (1-2), thermal ablation plus systemic therapy appeared to be associated with improved overall survival. Thermal ablation was equally effective in disease-free survival for treating solitary colorectal liver metastasis, whether with or without adjuvant systemic therapy.PMID:38597399 | DOI:10.1097/JS9.0000000000001397 (Source: Cancer Control)
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Jianming Li Chuan Pang Guangjian Liu Xiaoyan Xie De-Zhi Zhang Kai Li Zhishuai Li Guangbin He Erjiao Xu Huage Zhong Hong Yang Man Lu Kexin Lou Xiang Xie Sirong Lan Qian Li Guanghai Dai Jie Yu Ping Liang Source Type: research
Lung-protective effect of esketamine combined with distal limb ischemic preconditioning in elderly patients undergoing thoracoscopic radical surgery for lung cancer: a randomized controlled trial in 160 cases
CONCLUSION: In elderly patients undergoing thoracoscopic radical surgery for lung cancer, treatment with esketamine combined with LIP can alleviate acute lung injury by enhancing anti-inflammatory response to shorten postoperative hospital stay, reduce lung complications and promote the patients' recovery.PMID:38597439 | DOI:10.12122/j.issn.1673-4254.2024.03.09 (Source: Cancer Control)
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Y Yang G Liu Y Ou W Lu Source Type: research
Association between obesity and cancer risk in HIV-infected Asians
CONCLUSIONS: Obesity, which is one of the important health concerns in HIV management, was associated with an increased risk of non-AIDS-defining cancer but not AIDS-defining cancer.PMID:38597513 | DOI:10.1097/QAD.0000000000003904 (Source: Cancer Control)
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Yoonyoung Jang Taehwa Kim Yunsu Choi Kyoung Hwan Ahn Jung Ho Kim Hye Seong Youn Jeong Kim Shin-Woo Kim Jun Yong Choi Hyo Youl Kim Joon Young Song Hee Jung Choi Sang Il Kim Jang Wook Sohn BumSik Chin Bo-Youl Choi Boyoung Park Source Type: research
