Bioinspired and biomimetic strategies for inflammatory bowel disease therapy
This article highlights recent research on bioinspired and biomimetic strategies for the treatment of IBD and discusses the challenges and future directions in the field to advance the treatment of IBD.PMID:38511264 | DOI:10.1039/d3tb02995f (Source: Cancer Control)
Source: Cancer Control - March 21, 2024 Category: Cancer & Oncology Authors: Limei Zhang Peng Ye Huatai Zhu Liyu Zhu Yuting Ren Jiandu Lei Source Type: research

Optical Control of G-Actin with a Photoswitchable Latrunculin
J Am Chem Soc. 2024 Mar 21. doi: 10.1021/jacs.3c10776. Online ahead of print.ABSTRACTActin is one of the most abundant proteins in eukaryotic cells and is a key component of the cytoskeleton. A range of small molecules has emerged that interfere with actin dynamics by either binding to polymeric F-actin or monomeric G-actin to stabilize or destabilize filaments or prevent their formation and growth, respectively. Among these, the latrunculins, which bind to G-actin and affect polymerization, are widely used as tools to investigate actin-dependent cellular processes. Here, we report a photoswitchable version of latrunculin,...
Source: Cancer Control - March 21, 2024 Category: Cancer & Oncology Authors: Nynke A Vep řek Madeline H Cooper Laura Laprell Emily Jie-Ning Yang Sander Folkerts Ruiyang Bao Malgorzata Boczkowska Nicholas J Palmer Roberto Dominguez Thomas G Oertner Liza A Pon J Bradley Zuchero Dirk H Trauner Source Type: research

Longitudinal quality of life after sublobar resection and stereotactic body radiation therapy for early-stage non-small cell lung cancer
CONCLUSIONS: SBRT is associated with better QOL immediately posttreatment compared with sublobar resection. However, both treatment groups reported similar QOL at later time points, with a return to baseline QOL. These findings suggest that sublobar resection and SBRT have a similar impact on the QOL of patients with early-stage lung cancer deemed ineligible for lobectomy.PMID:38511395 | DOI:10.1002/cncr.35286 (Source: Cancer Control)
Source: Cancer Control - March 21, 2024 Category: Cancer & Oncology Authors: Juan P Wisnivesky Jeremy Mudd Kimberly Stone Christopher G Slatore Raja Flores Scott Swanson William Blackstock Cardinale B Smith Mark Chidel Kenneth Rosenzweig Claudia Henschke Jeffrey A Kern Source Type: research

Rational evolution for altering the ligand preference of estrogen receptor alpha
Protein Sci. 2024 Apr;33(4):e4940. doi: 10.1002/pro.4940.ABSTRACTEstrogen receptor α is commonly used in synthetic biology to control the activity of genome editing tools. The activating ligands, estrogens, however, interfere with various cellular processes, thereby limiting the applicability of this receptor. Altering its ligand preference to chemicals of choice solves this hurdle but requires adaptation of unspecified ligand-interacting residues. Here, we provide a solution by combining rational protein design with multi-site-directed mutagenesis and directed evolution of stably integrated variants in Saccharomyces cere...
Source: Cancer Control - March 21, 2024 Category: Cancer & Oncology Authors: Roy Eerlings Purvi Gupta Xiao Yin Lee Tien Nguyen Sarah El Kharraz Florian Handle Elien Smeets Lisa Moris Wout Devlies Bram Vandewinkel Irina Thiry Duy Tien Ta Anton Gorkovskiy Karin Voordeckers Els Henckaerts Vitor B Pinheiro Frank Claessens Kevin J Vers Source Type: research

Ewing Sarcoma Related protein 1 recognizes R-loops by binding DNA forks
In this study, we investigated the mechanism for EWSR1 to recognize an R-loop structure specifically. Using electrophoretic mobility shift assays (EMSA), we detected the high affinity binding of EWSR1 to substrates representing components found in R-loops. EWSR1 specificity could be isolated to the DNA fork region, which transitions between double- and single-stranded DNA. Our data suggests that the Zinc-finger domain (ZnF) with flanking arginine and glycine rich (RGG) domains provide high affinity binding, while the RNA recognition motif (RRM) with its RGG domains offer improved specificity. This model offers a rational f...
Source: Cancer Control - March 21, 2024 Category: Cancer & Oncology Authors: Michelle A Lay Valery F Thompson Ajibola D Adelakun Jacob C Schwartz Source Type: research

Identification of temporal shifts of oral bacteria in bone regeneration following mandibular bone defect injury and therapeutic surgery in a porcine model
Mol Oral Microbiol. 2024 Mar 21. doi: 10.1111/omi.12460. Online ahead of print.ABSTRACTBACKGROUND: Considered the second largest and most diverse microbiome after the gut, the human oral ecosystem is complex with diverse and niche-specific microorganisms. Although evidence is growing for the importance of oral microbiome in supporting a healthy immune system and preventing local and systemic infections, the influence of craniomaxillofacial (CMF) trauma and routine reconstructive surgical treatments on community structure and function of oral resident microbes remains unknown. CMF injuries affect a large number of people, n...
Source: Cancer Control - March 21, 2024 Category: Cancer & Oncology Authors: Fatemeh Sanjar David T Silliman Ian J Johnson Zayer Htut Trent J Peacock Samira F Thompson Gregory R Dion Md A Nahid John F Decker Kai P Leung Source Type: research

Microcirculatory Impairment and Cerebral Injury in Hydrocephalus and the Effects of Cerebrospinal Fluid Diversion
CONCLUSION: Rapid ventricular dilatation is associated with severe microvascular distortion, vascular regression, cortical hypoperfusion, and cellular changes that impair the recovery of CBF and motor function after CSF release. Moreover, CSF release may induce reperfusion injury. This pathophysiology should be taken into account when treating hydrocephalus.PMID:38511941 | DOI:10.1227/neu.0000000000002908 (Source: Cancer Control)
Source: Cancer Control - March 21, 2024 Category: Cancer & Oncology Authors: Kuo-Wei Chen Yong-Ren Chen Ling-Yu Yang Ya-Wen Cheng Sheng-Che Chou Yi-Hsing Chen Yi-Tzu Chen Sung-Tsang Hsieh Meng-Fai Kuo Kuo-Chuan Wang Source Type: research

Effect of recombinant human epidermal growth factor on neuropathic pain associated with radiotherapy for head and neck malignancies and nursing strategy
Conclusion: rhEGF can effectively alleviate neuropathic pain during and after radiotherapy in patients with head and neck malignancies, improve skin and mucosal response, and improve quality of life.PMID:38512026 | DOI:10.1080/00207454.2024.2334374 (Source: Cancer Control)
Source: Cancer Control - March 21, 2024 Category: Cancer & Oncology Authors: Ying Hong Zhi Cheng Lan Xu Jingjing Tang Juan Gao Source Type: research

Early switch from intravenous to oral antibiotic therapy in patients with cancer who have low-risk neutropenic sepsis: the EASI-SWITCH RCT
CONCLUSIONS: Non-inferiority for early oral switch could not be proven due to trial under-recruitment. The findings suggest this may be an acceptable treatment strategy for some patients who can adhere to such a treatment regimen and would prefer a potentially reduced duration of hospitalisation while accepting increased risk of treatment failure resulting in re-admission. Further research should explore tools for patient stratification for low-risk de-escalation or ambulatory pathways including use of biomarkers and/or point-of-care rapid microbiological testing as an adjunct to clinical decision-making tools. This could ...
Source: Cancer Control - March 21, 2024 Category: Cancer & Oncology Authors: Vicky Coyle Caroline Forde Richard Adams Ashley Agus Rosemary Barnes Ian Chau Mike Clarke Annmarie Doran Margaret Grayson Danny McAuley Cliona McDowell Glenn Phair Ruth Plummer Dawn Storey Anne Thomas Richard Wilson Ronan McMullan Source Type: research

A Signal-finding Study of Abemaciclib in Heavily Pretreated Patients with Metastatic Castration-Resistant Prostate Cancer: Results from CYCLONE 1
CONCLUSION: Abemaciclib monotherapy was well tolerated and showed clinical activity in this heavily pretreated population, nearly half with visceral metastases. This study is considered preliminary proof-of-concept and designates CDK4/6 as a valid therapeutic target in prostate cancer.PMID:38512117 | DOI:10.1158/1078-0432.CCR-23-3436 (Source: Cancer Control)
Source: Cancer Control - March 21, 2024 Category: Cancer & Oncology Authors: Neeraj Agarwal Daniel Castellano Teresa Alonso-Gordoa Jose Angel Arranz Arija Emeline Colomba Gwenaelle Gravis Loic Mourey Stephane Oudard Aude Fl échon Macarena Gonzalez Pablo M Maroto Michael T Schweizer Enrique Gallardo Erica Johnston Arjun Balar Nadi Source Type: research

Tumor treating fields suppress tumor cell growth and neurologic decline in models of spine metastases
JCI Insight. 2024 Mar 21:e176962. doi: 10.1172/jci.insight.176962. Online ahead of print.ABSTRACTSpine metastases can result in severe neurologic compromise and decreased overall survival. Despite treatment advances, local disease progression is frequent, highlighting the need for novel therapies. Tumor treating fields (TTFields) impair tumor cell replication and are influenced by properties of surrounding tissue. We hypothesize bone's dielectric properties will enhance TTFields mediated suppression of tumor growth in spine metastasis models. Computational modeling of TTFields intensity was performed following surgical res...
Source: Cancer Control - March 21, 2024 Category: Cancer & Oncology Authors: Daniel Ledbetter Romulo de Almeida Xizi Wu Ariel Naveh Chirag B Patel Queena Gonzalez Thomas H Beckham Robert North Laurence Rhines Jing Li Amol Ghia David Aten Claudio Tatsui Christopher Alvarez-Breckenridge Source Type: research

A rationally designed nuclei-targeting FAPI 04-based molecular probe with enhanced tumor uptake for PET/CT and fluorescence imaging
CONCLUSIONS: The NOTA-FAPI-MB was successfully synthesized, in which FAPI and MB simultaneously contributed to the targeting effect. Notably, the nuclear delivery mechanism of the probes improved intracellular retention time and targeting efficacy, broadening the imaging time window for fluorescence imaging. In vivo PET/CT demonstrated favorable performance of NOTA-FAPI-MB compared to [18F]F-FDG. This study highlights the significance of fluorescence imaging as an adjunct technique to PET/CT. Furthermore, the encouraging results obtained from the imaging of human HCC tissues hold promise for the potential application of NO...
Source: Cancer Control - March 21, 2024 Category: Cancer & Oncology Authors: Xingyang Zhao Guojin Zhang Jiali Chen Zirong Li Yusheng Shi Guiting Li Chuangyan Zhai Liming Nie Source Type: research

The effectiveness of digital psychosocial interventions on psychological distress, depression, anxiety, and health-related quality of life in patients with gynaecological cancer: a systematic review and meta-analysis
CONCLUSIONS: Digital psychosocial interventions probably reduced psychological distress and slightly reduced depression amongst patients with gynaecological cancer compared to the control group, which can be integrated into clinical practice. Additional trials with rigorous methodology and bigger sample sizes are needed to validate findings.TRIAL REGISTRATION: PROSPERO (CRD42023389502).PMID:38512538 | DOI:10.1007/s00520-024-08415-4 (Source: Cancer Control)
Source: Cancer Control - March 21, 2024 Category: Cancer & Oncology Authors: Kai Yoong Yen Jing Ying Cheng Jin-Qiu Li Zheng An Toh Hong-Gu He Source Type: research

The risk-based breast screening (RIBBS) study protocol: a personalized screening model for young women
This study is registered on Clinicaltrials.gov (NCT05675085).PMID:38512619 | DOI:10.1007/s11547-024-01797-9 (Source: Cancer Control)
Source: Cancer Control - March 21, 2024 Category: Cancer & Oncology Authors: Gisella Gennaro Lauro Bucchi Alessandra Ravaioli Manuel Zorzi Fabio Falcini Francesca Russo Francesca Caumo Source Type: research

Development of Biocompatible Cu(I)-Microdevices for Bioorthogonal Uncaging and Click Reactions
Chemistry. 2024 Mar 21:e202400611. doi: 10.1002/chem.202400611. Online ahead of print.ABSTRACTTransition-metal-catalysed bioorthogonal reactions emerged a decade ago as a novel strategy to implement spatiotemporal control over enzymatic functions and pharmacological interventions. The use of this methodology in experimental therapy is driven by the ambition of improving the tolerability and PK properties of clinically-used therapeutic agents. The preclinical potential of bioorthogonal catalysis has been validated in vitro and in vivo with the in situ generation of a broad range of drugs, including cytotoxic agents, anti-in...
Source: Cancer Control - March 21, 2024 Category: Cancer & Oncology Authors: Melissa van de L'Isle Stephen Croke Teresa Valero Asier Unciti-Broceta Source Type: research