Functional analysis of ESM1 by shRNA-mediated knockdown of its expression in papillary thyroid cancer cells
CONCLUSIONS: ESM1 was identified as a major gene in the occurrence and progression of PTC, which could increase the proliferation, migration, and invasion of PTC cells. It may be a promising diagnostic and therapeutic target gene.PMID:38626010 | DOI:10.1371/journal.pone.0298631 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Lijun Xie Limeng He Wei Zhang Hao Wang Source Type: research
Recent advances in immunotherapies against infectious diseases
Immunother Adv. 2020 Nov 25;1(1):ltaa007. doi: 10.1093/immadv/ltaa007. eCollection 2021 Jan.ABSTRACTImmunotherapies are disease management strategies that target or manipulate components of the immune system. Infectious diseases pose a significant threat to human health as evidenced by countries continuing to grapple with several emerging and re-emerging diseases, the most recent global health threat being the SARS-CoV2 pandemic. As such, various immunotherapeutic approaches are increasingly being investigated as alternative therapies for infectious diseases, resulting in significant advances towards the uncovering of path...
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Dharanidharan Ramamurthy Trishana Nundalall Sanele Cingo Neelakshi Mungra Maryam Karaan Krupa Naran Stefan Barth Source Type: research
De novo purine metabolism is a metabolic vulnerability of cancers with low p16 expression
Cancer Res Commun. 2024 Apr 16. doi: 10.1158/2767-9764.CRC-23-0450. Online ahead of print.ABSTRACTp16 is a tumor suppressor encoded by the CDKN2A gene whose expression is lost in ~50% of all human cancers. In its canonical role, p16 inhibits the G1-S phase cell cycle progression through suppression of cyclin dependent kinases. Interestingly, p16 also has roles in metabolic reprogramming, and we previously published that loss of p16 promotes nucleotide synthesis via the pentose phosphate pathway. However, the broader impact of p16/CDKN2A loss on other nucleotide metabolic pathways and potential therapeutic targets remains u...
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Naveen Kumar Tangudu Raquel Buj Hui Wang Jiefei Wang Aidan R Cole Apoorva Uboveja Richard Fang Amandine Amalric Baixue Yang Adam Chatoff Claudia V Crispim Peter Sajjakulnukit Maureen A Lyons Kristine Cooper Nadine Hempel Costas A Lyssiotis Uma R Chandran Source Type: research
Polymeric Nanoparticles for Drug Delivery
Chem Rev. 2024 Apr 16. doi: 10.1021/acs.chemrev.3c00705. Online ahead of print.ABSTRACTThe recent emergence of nanomedicine has revolutionized the therapeutic landscape and necessitated the creation of more sophisticated drug delivery systems. Polymeric nanoparticles sit at the forefront of numerous promising drug delivery designs, due to their unmatched control over physiochemical properties such as size, shape, architecture, charge, and surface functionality. Furthermore, polymeric nanoparticles have the ability to navigate various biological barriers to precisely target specific sites within the body, encapsulate a dive...
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Maximilian A Beach Umeka Nayanathara Yanting Gao Changhe Zhang Yijun Xiong Yufu Wang Georgina K Such Source Type: research
Iron regulates the quiescence of naive CD4 T cells by controlling mitochondria and cellular metabolism
Proc Natl Acad Sci U S A. 2024 Apr 23;121(17):e2318420121. doi: 10.1073/pnas.2318420121. Epub 2024 Apr 15.ABSTRACTIn response to an immune challenge, naive T cells undergo a transition from a quiescent to an activated state acquiring the effector function. Concurrently, these T cells reprogram cellular metabolism, which is regulated by iron. We and others have shown that iron homeostasis controls proliferation and mitochondrial function, but the underlying mechanisms are poorly understood. Given that iron derived from heme makes up a large portion of the cellular iron pool, we investigated iron homeostasis in T cells using...
Source: Cancer Control - April 15, 2024 Category: Cancer & Oncology Authors: Ajay Kumar Chenxian Ye Afia Nkansah Thomas Decoville Garrett M Fogo Peter Sajjakulnukit Mack B Reynolds Li Zhang Osbourne Quaye Young-Ah Seo Thomas H Sanderson Costas A Lyssiotis Cheong-Hee Chang Source Type: research
Oncology: What You May Have Missed in 2023
This article highlights important publications from 2023 on topics across a wide spectrum relating to the management of oncology patients. The literature was screened for significant new evidence that is relevant to internal medicine specialists and subspecialists whose focus is not oncology. Two articles address the importance of social interventions targeting end-of-life care for low-income and minority patients and the well-being of caregivers. Two additional articles address screening considerations in patients at risk for colorectal and lung cancer. Two more articles address safe use of hormone-related therapies to tr...
Source: Cancer Control - April 15, 2024 Category: Cancer & Oncology Authors: Courtney H Coschi Lorin Dodbiba DuPont Guerry Source Type: research
Modulators for palmitoylation of proteins and small molecules
Eur J Med Chem. 2024 Apr 12;271:116408. doi: 10.1016/j.ejmech.2024.116408. Online ahead of print.ABSTRACTAs an essential form of lipid modification for maintaining vital cellular functions, palmitoylation plays an important role in in the regulation of various physiological processes, serving as a promising therapeutic target for diseases like cancer and neurological disorders. Ongoing research has revealed that palmitoylation can be categorized into three distinct types: N-palmitoylation, O-palmitoylation and S-palmitoylation. Herein this paper provides an overview of the regulatory enzymes involved in palmitoylation, inc...
Source: Cancer Control - April 15, 2024 Category: Cancer & Oncology Authors: Zeshuai Fan Yuchen Hao Yidan Huo Fei Cao Longfei Li Jianmei Xu Yali Song Kan Yang Source Type: research
Safety and efficacy of percutaneous cryoablation for primary and metastatic pleural based tumors
CONCLUSION: Percutaneous cryoablation for pleural lesions is associated with a long duration of local control and most complications were minor and self-limited.PMID:38621339 | DOI:10.1016/j.ejrad.2024.111465 (Source: Cancer Control)
Source: Cancer Control - April 15, 2024 Category: Cancer & Oncology Authors: Erica S Alexander Elena N Petre Michael Offin Marjorie Zauderer Ken Zhao Vlasios Sotirchos Stephen B Solomon Etay Ziv Source Type: research
Listeria monocytogenes infections in hematopoietic cell transplant recipients: clinical manifestations and risk factors: A multinational retrospective case control study of the Infectious Diseases Working Party (IDWP) of the European Society for Blood and Marrow Transplantation (EBMT)
CONCLUSIONS: HCT patients have an increased risk for listeriosis compared to general population. Listeriosis cause severe disease with septic shock and mortality. Neurolisteriosis can present with non-specific signs and normal imaging. Lymphocytopenia and non-first HCT are associated with increased risk of listeriosis; cotrimoxazole was not protective.PMID:38621480 | DOI:10.1016/j.jtct.2024.04.008 (Source: Cancer Control)
Source: Cancer Control - April 15, 2024 Category: Cancer & Oncology Authors: Dina Averbuch Gloria Tridello Lotus Wendel Maija It älä-Remes Ilana Oren Michal Karas Nicole Blijlevens Yves Beguin Annoek Broers Elisabetta Calore Chiara Cattaneo Cecilia Isaksson Christine Robin Alain Gadisseur Johan Maertens Ann De Becker Catherina L Source Type: research
In silico design of a novel multi-epitope vaccine against HCV infection through immunoinformatics approaches
This study is the first to present this epitopes-adjuvant combination. The vaccine had acceptable physicochemical characteristics. The vaccine's 3D structure was predicted and validated. The vaccine's binding stability with Toll-like receptor 2 (TLR2) and TLR4 was confirmed using molecular docking and molecular dynamics (MD) simulation. The immune simulation revealed the vaccine's efficacy by increasing the population of B and T cells in response to vaccination. In silico expression in Escherichia coli (E. coli) was also successful.PMID:38621559 | DOI:10.1016/j.ijbiomac.2024.131517 (Source: Cancer Control)
Source: Cancer Control - April 15, 2024 Category: Cancer & Oncology Authors: Sajjad Ahmad Fatemeh Mobini Demneh Bushra Rehman Taghreed N Almanaa Nahid Akhtar Hamidreza Pazoki-Toroudi Ali Shojaeian Mahdi Ghatrehsamani Samira Sanami Source Type: research
Thoracic Proton Minibeam Radiation Therapy: Tissue Preservation and Survival Advantage over Conventional Proton Therapy
CONCLUSION: pMBRT appears suitable to treat moving targets, holding a significant ability to preserve healthy lung tissue, even without respiratory control or precise targeting.PMID:38621606 | DOI:10.1016/j.ijrobp.2024.04.011 (Source: Cancer Control)
Source: Cancer Control - April 15, 2024 Category: Cancer & Oncology Authors: Anna ïg Bertho Ramon Ortiz Mathieu Maurin Marjorie Juchaux Crist èle Gilbert Julie Espenon Gabriel Ramasamy Annalisa Patriarca Ludovic De Marzi Fr édéric Pouzoulet Yolanda Prezado Source Type: research
Impact of radiation therapy modalities on loco-regional control in inflammatory breast cancer
CONCLUSIONS: Contrary to other important series, this large retrospective multicentric study did not show a loco-regional or distant control benefit of intensified radiotherapy. Pooled prospective studies and meta-analyses of intensified radiotherapy are warranted to endorse this approach.PMID:38621608 | DOI:10.1016/j.ijrobp.2024.04.010 (Source: Cancer Control)
Source: Cancer Control - April 15, 2024 Category: Cancer & Oncology Authors: Maximilien Rog é Youlia Kirova Emilie L évêque Marin Guigo Alison Johnson Rafik Nebbache Eleonor Rivin Del Campo Ioana Lazarescu St éphanie Servagi Augustin Mervoyer Axel Cailleteau S ébastien Thureau Juliette Thariat Source Type: research
Integration of the geriatric palliative care in oncological care of elderly patient with cancer
The objective of this article is to describe the profile of the population attended to by the palliative geriatrics clinic and to evaluate the symptomatic control derived from the care provided.METHODS: During 2017 a model based on a holistic approach was implemented, in this model the team geriatric palliative care plays a fundamental role by being part of the palliative care team and functioning as a liaison with the oncology team and other required services. We outlined the profile of 100 patients aged 70 and older seen between 2017 and 2019 at our geriatric palliative care clinic. Descriptive statistics were used. In a...
Source: Cancer Control - April 15, 2024 Category: Cancer & Oncology Authors: Josafat Napole ón Sánchez-Dávila Emma L Ver ástegui Adriana Pe ña-Nieves Silvia Rosa Allende-P érez Source Type: research
Multi-modular metabolic engineering and efflux engineering for enhanced lycopene production in recombinant Saccharomyces cerevisiae
J Ind Microbiol Biotechnol. 2024 Apr 15:kuae015. doi: 10.1093/jimb/kuae015. Online ahead of print.ABSTRACTLycopene has been widely used in the food industry and medical field due to its antioxidant, anti-cancer, and anti-inflammatory properties. However, achieving efficient manufacture of lycopene using chassis cells on an industrial scale remains a major challenge. Herein, we attempted to integrate multiple metabolic engineering strategies to establish an efficient and balanced lycopene biosynthetic system in Saccharomyces cerevisiae. First, the lycopene synthesis pathway was modularized to sequentially enhance the metabo...
Source: Cancer Control - April 15, 2024 Category: Cancer & Oncology Authors: Guangxi Huang Jiarong Li Jingyuan Lin Changqing Duan Guoliang Yan Source Type: research
Diet and Cancer Metabolism
Cold Spring Harb Perspect Med. 2024 Apr 15:a041549. doi: 10.1101/cshperspect.a041549. Online ahead of print.ABSTRACTDiet and exercise are modifiable lifestyle factors known to have a major influence on metabolism. Clinical practice addresses diseases of altered metabolism such as diabetes or hypertension by altering these factors. Despite enormous public interest, there are limited defined diet and exercise regimens for cancer patients. Nevertheless, the molecular basis of cancer has converged over the past 15 years on an essential role for altered metabolism in cancer. However, our understanding of the molecular mechanism...
Source: Cancer Control - April 15, 2024 Category: Cancer & Oncology Authors: Jason W Locasale Marcus D Goncalves Maira Di Tano Guillermo Burgos-Barragan Source Type: research
