Race, Ethnicity, and Delayed Time to COVID-19 Testing Among US Health Care Workers
CONCLUSIONS AND RELEVANCE: In this cross-sectional study of HCP, compared with non-Hispanic White HCP and clinical HCP with graduate degrees, non-Hispanic Black HCP, non-Hispanic HCP of other races, and HCP all other professional and education backgrounds were more likely to have delayed COVID-19 testing. These findings suggest that time to testing may serve as a valuable metric in evaluating sociodemographic disparities in the response to COVID-19 and future health mitigation strategies.PMID:38598239 | DOI:10.1001/jamanetworkopen.2024.5697 (Source: Cancer Control)
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: DaMarcus E Baymon J Priyanka Vakkalanka Anusha Krishnadasan Nicholas M Mohr David A Talan Melissa Briggs Hagen Kelli Wallace Karisa K Harland Imoigele P Aisiku Peter C Hou Preventing Emerging Infections Through Vaccine Effectiveness Testing (PREVENT) proj Source Type: research
Exosome-Coated Prussian Blue Nanoparticles for Specific Targeting and Treatment of Glioblastoma
ACS Appl Mater Interfaces. 2024 Apr 10. doi: 10.1021/acsami.4c02364. Online ahead of print.ABSTRACTGlioblastoma is one of the most aggressive and invasive types of brain cancer with a 5-year survival rate of 6.8%. With limited options, patients often have poor quality of life and are moved to palliative care after diagnosis. As a result, there is an extreme need for a novel theranostic method that allows for early diagnosis and noninvasive treatment as current peptide-based delivery standards may have off-target effects. Prussian Blue nanoparticles (PBNPs) have recently been investigated as photoacoustic imaging (PAI) and ...
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Meghan L Hill Seock-Jin Chung Hyun-Joo Woo Cho Rong Park Kay Hadrick Md Nafiujjaman Panangattukara Prabhakaran Praveen Kumar Leila Mwangi Rachna Parikh Taeho Kim Source Type: research
An alternating-intervention pilot trial on the impact of an informational handout on patient-reported outcomes and follow-up after lung cancer screening
CONCLUSIONS: There were no differences in self-reported outcomes between the groups or overall follow-up adherence. Those receiving the intervention did report greater understanding and knowledge of key LCS components, and those with positive results had a higher rate of follow-up. This may represent a feasible component of a multi-level intervention to address knowledge and follow-up for LCS.TRIAL REGISTRATION: ClinicalTrials.gov NCT05265897.PMID:38598511 | DOI:10.1371/journal.pone.0300352 (Source: Cancer Control)
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Matthew Triplette Erin K Kross Madison Snidarich Shahida Shahrir Daniel S Hippe Kristina Crothers Source Type: research
Epigenetic Control of Cancer Cell Dormancy and Awakening in Endocrine Therapy Resistance
Cancer Discov. 2024 Apr 10:OF1-OF3. doi: 10.1158/2159-8290.CD-24-0282. Online ahead of print.ABSTRACTRosano, Sofyali, Dhiman, and colleagues show that epigenetic-related changes occur in endocrine therapy (ET)-induced dormancy in estrogen receptor positive (ER+) breast cancer, as well as in its reawakening. Targeting these epigenetic changes blocks the entrance to dormancy and reduces the persister cancer cell population, enhancing the cytotoxic effects of ET in vitro. See related article by Rosano et al. (9).PMID:38598672 | DOI:10.1158/2159-8290.CD-24-0282 (Source: Cancer Control)
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Arnau Llinas-Bertran Meritxell Bellet-Ezquerra Jose A Seoane Source Type: research
The Potential Mediating Effect of Symptom Burden on Demoralization Through Locus of Control and Coping Strategies in Chinese Patients With Cancer
CONCLUSIONS: Symptom burden affects demoralization not only directly but also indirectly. Coping strategies play an important mediating role between symptom burden, locus of control, and demoralization in patients with cancer.IMPLICATIONS FOR PRACTICE: It is urgent to screen demoralization and identify patients with high symptom burden, maladaptive locus of control, or coping strategies. For the patients targeted, a more comprehensive and systematic approach to symptom management and more appropriate guidance related to adaptive coping strategies are needed.PMID:38598755 | DOI:10.1097/NCC.0000000000001350 (Source: Cancer Control)
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Xiaoxin Liu Yanhua Li Lezhi Li Juan Li Jiao Yang Lirong Huang Min Yao Linlin Yang Qun Yang Source Type: research
Alectinib in Resected ALK-Positive Non-Small-Cell Lung Cancer
CONCLUSIONS: Among patients with resected ALK-positive NSCLC of stage IB, II, or IIIA, adjuvant alectinib significantly improved disease-free survival as compared with platinum-based chemotherapy. (Funded by F. Hoffmann-La Roche; ALINA ClinicalTrials.gov number, NCT03456076.).PMID:38598794 | DOI:10.1056/NEJMoa2310532 (Source: Cancer Control)
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Yi-Long Wu Rafal Dziadziuszko Jin Seok Ahn Fabrice Barlesi Makoto Nishio Dae Ho Lee Jong-Seok Lee Wenzhao Zhong Hidehito Horinouchi Weimin Mao Maximilian Hochmair Filippo de Marinis M Rita Migliorino Igor Bondarenko Shun Lu Qun Wang Tania Ochi Lohmann Tin Source Type: research
Hypoxia research, where to now?
Trends Biochem Sci. 2024 Apr 9:S0968-0004(24)00074-4. doi: 10.1016/j.tibs.2024.03.008. Online ahead of print.ABSTRACTInvestigating how cells and organisms sense and respond to O2 levels is essential to our understanding of physiology and pathology. This field has advanced considerably since the discovery of the major transcription factor family, hypoxia-inducible factor (HIF), and the enzymes that control its levels: prolyl hydroxylases (PHDs). However, with its expansion, new complexities have emerged. Herein we highlight three main areas where, in our opinion, the research community could direct some of their attention. ...
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Brian M Ortmann Cormac T Taylor Sonia Rocha Source Type: research
Immune checkpoints in autoimmune vasculitis
Best Pract Res Clin Rheumatol. 2024 Apr 9:101943. doi: 10.1016/j.berh.2024.101943. Online ahead of print.ABSTRACTGiant cell arteritis (GCA) is a prototypic autoimmune disease with a highly selective tissue tropism for medium and large arteries. Extravascular GCA manifests with intense systemic inflammation and polymyalgia rheumatica; vascular GCA results in vessel wall damage and stenosis, causing tissue ischemia. Typical granulomatous infiltrates in affected arteries are composed of CD4+ T cells and hyperactivated macrophages, signifying the involvement of the innate and adaptive immune system. Lesional CD4+ T cells under...
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Yuki Sato Maria Tada Jorg J Goronzy Cornelia M Weyand Source Type: research
Delays in Care by Race, Ethnicity, and Gender Before and During the COVID-19 Pandemic Using Cross-Sectional Data From National Institutes of Health's All of Us Research Program
CONCLUSIONS: In this study of diverse U.S. participants, women and Black and other race-ethnicity men were more likely than white men to report delays in care, both before and during COVID-19. Addressing care delays may be necessary to ameliorate health disparities by race-ethnicity and gender.PMID:38599938 | DOI:10.1016/j.whi.2024.02.003 (Source: Cancer Control)
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Katherine A Hill Vivian Col ón-López Source Type: research
Pro-cancer role of CD276 as a novel biomarker for clear cell renal cell carcinoma
CONCLUSION: CD276 expression was significantly increased in ccRCC tissues and cells and positively correlated with patient prognosis. CD276 is a potential prognostic biomarker of ccRCC. Overall, this study provides a potential therapeutic strategy for ccRCC.PMID:38600002 | DOI:10.1016/j.urolonc.2024.03.018 (Source: Cancer Control)
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Zhi-Yu Zhang Jian-Hao Xu Jiang-Lei Zhang Yu-Xin Lin Jun Ou-Yang Source Type: research
Impact of virtual education based on health belief model on cervical cancer screening behavior in middle-aged women: A quasi-experimental study
CONCLUSION: Web-based educational intervention based on HBM using different strategies such as question and answer, presentation of infographics, lectures, brainstorming, showing videos and numerous educational images can be an effective way for increasing knowledge and cognitive variables of women and doing Pap smear test.PMID:38600048 | DOI:10.1002/cnr2.2058 (Source: Cancer Control)
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Mahdieh Sadat Khoshnazar Mohammad Javad Tarrahi Hossein Shahnazi Source Type: research
Network-based identification of key proteins and repositioning of drugs for non-small cell lung cancer
CONCLUSION: Hence, there is a possibility of repurposing these drugs for the treatment of non-small-cell lung cancer.PMID:38600056 | DOI:10.1002/cnr2.2031 (Source: Cancer Control)
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Oluwatosin Maryam Adeyemo Zainab Ashimiyu-Abdusalam Mary Adewunmi Temitope Ayanfunke Ayano Muhammad Sohaib Reem Abdel-Salam Source Type: research
Effect of 2-methoxyestradiol on mammary tumor initiation and progression
CONCLUSION: Taken together, these findings suggest that 2-ME promotes early-stage BC development.PMID:38600057 | DOI:10.1002/cnr2.2068 (Source: Cancer Control)
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Kimberly T Peta Chrisna Durandt Marlene B van Heerden Anna M Joubert Michael S Pepper Melvin A Ambele Source Type: research
Predictors for survival in patients with Alzheimer's disease: a large comprehensive meta-analysis
Transl Psychiatry. 2024 Apr 10;14(1):184. doi: 10.1038/s41398-024-02897-w.ABSTRACTThe prevalence of Alzheimer's disease (AD) is increasing as the population ages, and patients with AD have a poor prognosis. However, knowledge on factors for predicting the survival of AD remains sparse. Here, we aimed to systematically explore predictors of AD survival. We searched the PubMed, Embase and Cochrane databases for relevant literature from inception to December 2022. Cohort and case-control studies were selected, and multivariable adjusted relative risks (RRs) were pooled by random-effects models. A total of 40,784 reports were ...
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Xiaoting Zheng Shichan Wang Jingxuan Huang Chunyu Li Huifang Shang Source Type: research
Mechanical state transitions in the regulation of tissue form and function
Nat Rev Mol Cell Biol. 2024 Apr 10. doi: 10.1038/s41580-024-00719-x. Online ahead of print.ABSTRACTFrom embryonic development, postnatal growth and adult homeostasis to reparative and disease states, cells and tissues undergo constant changes in genome activity, cell fate, proliferation, movement, metabolism and growth. Importantly, these biological state transitions are coupled to changes in the mechanical and material properties of cells and tissues, termed mechanical state transitions. These mechanical states share features with physical states of matter, liquids and solids. Tissues can switch between mechanical states ...
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Yanlan Mao Sara A Wickstr öm Source Type: research
