Tempol effect on oxidative and mitochondrial markers in preclinical models for prostate cancer
CONCLUSION: Tempol can be considered a beneficial therapy for PCa treatment considering its antioxidant and low toxicity properties, however the PCa progression must be evaluated to get successful therapy.PMID:38623092 | PMC:PMC11015989 | DOI:10.1093/toxres/tfae056 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Isabela Maria Urra Rossetto Felipe Rabelo Santos Heloina Mariano da Silva Elaine Minatel Mariana Mesquitta Marcos Jos é Salvador F ábio Montico Val éria Helena Alves Cagnon Source Type: research
Efficacy of aerobic and resistance exercises on cancer pain: A meta-analysis of randomised controlled trials
CONCLUSIONS: Aerobic and resistance exercises are tolerable and effective adjunct therapies to reduce cancer-related pain while also improving physical function, fatigue and mood. Future RCTs of dose, frequency, compliance and exercise type in specific cancer settings are required.PMID:38623224 | PMC:PMC11016720 | DOI:10.1016/j.heliyon.2024.e29193 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Philip D Austin Wei Lee Daniel Sj Costa Alison Ritchie Melanie R Lovell Source Type: research
Predicting prostate cancer recurrence: Introducing PCRPS, an advanced online web server
CONCLUSION: Overall, our study provides an attractive tool to further guide the clinical management and individualized treatment for PCa.PMID:38623253 | PMC:PMC11016622 | DOI:10.1016/j.heliyon.2024.e28878 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Xianya He Sheng Hu Chen Wang Yongjun Yang Zhuo Li Mingqiang Zeng Guangqing Song Yuanwei Li Qiang Lu Source Type: research
Proposal of a new dermoscopic criterion for pigmented basal cell carcinoma: a multicentre retrospective study
Dermatol Reports. 2023 Aug 24;16(1):9691. doi: 10.4081/dr.2023.9691. eCollection 2024 Mar 12.ABSTRACTDermoscopy is widely used for the diagnosis of skin cancer and it increases the accuracy of basal cell carcinoma (BCC) detection. BCC dermoscopic criteria have been updated and divided into vascular, pigment-related, and non-vascular/non-pigment-related. Our multicenter retrospective study tested a new dermoscopic pigment-related characteristic to detect pigmented BCC (pBCC) [brown homogeneous blotches (BHB)]. Cases of pBCC were collected from the databases of IDI-IRCCS of Rome and from three Italian private dermatology cen...
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Roberto Manca Anna Dattolo Francesco Valenzano Marina Castriota Alessandro Martella Giovanna Galdo Giuseppe Argenziano Damiano Abeni Luca Fania Source Type: research
Trends in mortality from gastrointestinal, hepatic, and pancreatic cancers in the United States: A comprehensive analysis (1999-2020)
CONCLUSION: While overall gastrointestinal cancer-related mortality declined significantly in the United States from 1999 to 2020, mortality from some cancers increased. Furthermore, differences between sexes and racial groups underscore crucial differences in gastrointestinal cancer mortality, highlighting areas for future research.PMID:38623490 | PMC:PMC11017855 | DOI:10.1002/jgh3.13064 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Hassam Ali Rizwan Ishtiaq Brandon Tedder Joshua Zweigle Romina Nomigolzar Dushyant S Dahiya Vishali Moond Amir Humza Sohail Pratik Patel Debargha Basuli Hans L Tillmann Source Type: research
Identification of Lower Grade Glioma Antigens Based on Ferroptosis Status for mRNA Vaccine Development
CONCLUSION: HOTAIR, IDO1, KIF20A, NR5A2, and RRM2 were identified as promising candidate antigens for the development of an LGG mRNA vaccine, particularly offering potential benefits to FS2 and FS4 patients.PMID:38623558 | PMC:PMC11018127 | DOI:10.2147/PGPM.S449230 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Zhenxiang Zhao Na Xing Hao Guo Jianfeng Li Guozhu Sun Source Type: research
Epstein-Barr Virus DNA Is Associated With Conjunctival Squamous Cell Carcinomas: A Case-Control Study From Zimbabwe
Open Forum Infect Dis. 2024 Mar 25;11(4):ofae165. doi: 10.1093/ofid/ofae165. eCollection 2024 Apr.ABSTRACTIncidence of conjunctival squamous cell carcinoma (cSCC) in Zimbabwe is >30-fold higher than the global average. cSCC risk is notably higher among people with human immunodeficiency virus, implicating impaired immune response and a yet unknown infectious etiology. Formalin-fixed, paraffin-embedded blocks from Zimbabwe, comprising conjunctival precancer (n = 78), invasive cSCC cases (n = 148) and nonmalignant eye lesions (n = 119), were tested for multiple DNA viruses using Luminex bead-based technology. Epstein-Barr...
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Racheal S Dube Mandishora Luisa Galati Richard R Reich Jean-Damien Combes Sandrine McKay-Chopin Rudo Makunike-Mutasa Rangarirai Masanganise Bevele Gwambiwa Tricia Magombei Francesco Alfredo Zito Pagona Lagiou Gary M Clifford Anna R Giuliano Anna E Coghill Source Type: research
Thymosin alpha1 combined with XELOX improves immune function and reduces serum tumor markers in colorectal cancer patients after radical surgery
This study aimed to investigate the efficacy of thymosin α1 combined with XELOX in improving immune function and reducing serum tumor markers in patients with colorectal cancer (CRC) after radical surgery. A total of 180 patients who underwent radical surgery for CRC were divided into two groups: an observation group (n = 94) receiving thymosin α1 in combination with XELOX and a control group (n = 86) receiving XELOX alone. Immune function, inflammatory factor levels, serum tumor markers, and quality of life were assessed before and after treatment. Adverse reactions and recurrence rates were compared between the two gro...
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Li Sha Hao Zhang Xiwei Zhang Source Type: research
Application Value of CYFRA21-1 Combined with NSE, CEA, and SCC-Ag in Lung Cancer
CONCLUSIONS: The combined assay of CYFRA21-1, NSE, and CEA addresses the aspects of accuracy, sensitivity, specificity, and economic cost and should be considered as a potential diagnostic test in LC.PMID:38623667 | DOI:10.7754/Clin.Lab.2023.230662 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Yuping Fu Dandan Li Ya Zhu Sha Yan Xia Wang Zhenshuai Lian Qi Xie Zhi'an He Source Type: research
Comprehensive Assessment of the Intrinsic Pancreatic Microbiome
CONCLUSIONS: Our analysis of the pancreatic microbiome demonstrated very low intrinsic biomass that is relatively conserved across diverse neoplastic conditions and thus unlikely to drive malignant transformation.PMID:38623754 | DOI:10.1097/SLA.0000000000006299 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Austin M Eckhoff Ashley A Fletcher Matthew S Kelly Anders Dohlman Caitlin A McIntyre Xiling Shen Matthew K Iyer Daniel P Nussbaum Peter J Allen Source Type: research
Continuous immunotherapy beyond progression in clinical practice for small cell lung cancer
We describe the effectiveness of continuous ICIs beyond progression in SCLC. Medical courses of SCLC patients treated with chemo-immunotherapy were retrospectively reviewed at our hospital. The study included 36 patients with a median age of 73 years (range 46-83 years) who introduced chemo-immunotherapy between September 2019 and December 2022. Atezolizumab and durvalumab in combination with platinum plus etoposide were administered in 24 and 12 patients, respectively. The overall response rate was 67% and the disease control rate was 86%. The median progression-free survival and time to treatment failure (TTF) were 5.1 a...
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Ken Yamamoto Taira Ninomaru Hideaki Okada Katsuya Hirano Temiko Shimada Akito Hata Source Type: research
Investigating Disparities in Hypopharyngeal/Laryngeal Cancer Survival in Florida With Geospatial Mapping Analysis
CONCLUSION: Our findings suggest that sociodemographic and clinical factors impact OS from hypopharyngeal/laryngeal cancer in Florida and vary geographically within the state. These results will help guide future public health interventions.PMID:38623948 | DOI:10.1177/10732748241246958 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Uche C Ezeh Abdurrahman Al-Awady Isabella Buitron Ming Lee Garrett Forman Sophia Peifer Alana Deo Larissa Sweeny Donald Weed Erin K Kobetz Isildinha M Reis Elizabeth Franzmann Source Type: research
Self-Assembled Recombinant Elastin and Globular Protein Vesicles with Tunable Properties for Diverse Applications
Acc Chem Res. 2024 Apr 16. doi: 10.1021/acs.accounts.3c00694. Online ahead of print.ABSTRACTConspectusVesicles are self-assembled structures comprised of a membrane-like exterior surrounding a hollow lumen with applications in drug delivery, artificial cells, and micro-bioreactors. Lipid or polymer vesicles are the most common and are made of lipids or polymers, respectively. They are highly useful structures for many applications but it can be challenging to decorate them with proteins or encapsulate proteins in them, owing to the use of organic solvent in their formation and the large size of proteins relative to lipid o...
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Mikaela A Gray Mariela R Rodriguez-Otero Julie A Champion Source Type: research
Investigating the role connective tissue fibroblasts play in the altered muscle anatomy associated with the limb abnormality, Radial Dysplasia
J Anat. 2024 Apr 16. doi: 10.1111/joa.14040. Online ahead of print.ABSTRACTRadial dysplasia (RD) is a congenital upper limb birth defect that presents with changes to the upper limb anatomy, including a shortened or absent radius, bowed ulna, thumb malformations, a radially deviated hand and a range of muscle and tendon malformations, including absent or abnormally shaped muscle bundles. Current treatments to address wrist instability caused by a shortened or absent radius frequently require an initial soft tissue distraction intervention followed by a wrist stabilisation procedure. Following these surgical interventions, ...
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: George R F Murphy Eleanor Feneck James Paget Branavan Sivakumar Gill Smith Malcolm P O Logan Source Type: research
Platinum-based adjuvant chemoradiotherapy versus adjuvant radiotherapy in patients with head and neck adenoid cystic carcinoma
CONCLUSION: In terms of reducing locoregional failures in HNACC patients, POCRT may potentially offer a more effective therapeutic approach than using PORT alone, although it also entails an augmented burden of treatment-related toxicity.PMID:38625410 | DOI:10.1007/s00432-024-05719-0 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Zichen Qiu Zheng Wu Xiong Zhou Minchuan Lin Yong Su Yalan Tao Source Type: research
