Brazilin Actuates Ferroptosis in Breast Cancer Cells via p53/SLC7A11/GPX4 Signaling Pathway
CONCLUSIONS: Brazilin actuated ferroptosis in breast cancer cells, and the underlying mechanism is mainly associated with the p53/SLC7A11/GPX4 signaling pathway.PMID:38652227 | DOI:10.1007/s11655-024-4104-y (Source: Cancer Control)
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Dan He Xiao-Ning Tan Lin-Pei Li Wen-Hui Gao Xue-Fei Tian Pu-Hua Zeng Source Type: research
Diagnostic and therapeutic use of oral micronized progesterone in endocrinology
Rev Endocr Metab Disord. 2024 Apr 23. doi: 10.1007/s11154-024-09882-0. Online ahead of print.ABSTRACTProgesterone is a natural steroid hormone, while progestins are synthetic molecules. In the female reproductive system, progesterone contributes to the control of luteinizing hormone and follicle-stimulating hormone secretion and their pulsatility, via its receptors on the kisspeptin, neurokinin B, and dynorphin neurons in the hypothalamus. Progesterone together with estradiol controls the cyclic changes of proliferation and decidualization of the endometrium; exerts anti-mitogenic actions on endometrial epithelial cells; r...
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Eleni Memi Polina Pavli Papagianni Maria Nikolaos Vrachnis George Mastorakos Source Type: research
Interactions between folate metabolism-related nutrients and polymorphisms on colorectal cancer risk: a case-control study in the Basque country
Eur J Nutr. 2024 Apr 23. doi: 10.1007/s00394-024-03371-5. Online ahead of print.ABSTRACTFolate-mediated one-carbon metabolism (FOCM) plays an important role in colorectal carcinogenesis. Previous studies have assessed the role of folate-mediated one-carbon metabolism (FOCM)-related gene-diet interaction in the aetiology of colorectal cancer (CRC), however, the results remained inconclusive. Thus, this study aimed to investigate dietary factors and genetic variants related to FOCM, as well as potential nutrient-gene and nutrient-lifestyle interactions, on CRC risk. This observational study included 229 patients diagnosed wi...
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Sara Corchero-Palacios Iker Alegria-Lertxundi Marian M de Pancorbo Marta Arroyo-Izaga Source Type: research
Global untargeted and individual targeted plasma metabolomics of breast cancer recurrence modified by hormone receptors
CONCLUSION: Our study revealed that plasma metabolites were significantly different between recurrent and non-recurrent patients, proposing therapeutic insights for breast cancer prognosis.PMID:38652345 | DOI:10.1007/s12282-024-01579-1 (Source: Cancer Control)
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Pei-Jing Yang Eing-Mei Tsai Ming-Feng Hou Yen-Jung Lee Tsu-Nai Wang Source Type: research
Electromagnetic Modulation of Cell Behavior: Unraveling the Positive Impacts in a Comprehensive Review
Ann Biomed Eng. 2024 Apr 23. doi: 10.1007/s10439-024-03519-8. Online ahead of print.ABSTRACTThere are numerous effective procedures for cell signaling, in which humans directly transmit detectable signals to cells to govern their essential behaviors. From a biomedical perspective, the cellular response to the combined influence of electrical and magnetic fields holds significant promise in various domains, such as cancer treatment, targeted drug delivery, gene therapy, and wound healing. Among these modern cell signaling methods, electromagnetic fields (EMFs) play a pivotal role; however, there remains a paucity of knowled...
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Amirhossein Bahmanpour Seyed Majid Ghoreishian Azadeh Sepahvandi Source Type: research
Short- and long-term post-nephrectomy outcomes for retroperitoneal liposarcoma from a high-volume sarcoma center: a propensity score matching analysis
CONCLUSIONS: RLPS resection with nephrectomy is related to a mild progression of renal impairment; however, dialysis is rare. En bloc nephrectomy for complete resection of RLPS is safe and improves local control.PMID:38652434 | DOI:10.1007/s10147-024-02530-2 (Source: Cancer Control)
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Guoqiang Xue Zhen Wang Bonan Liu Chengpeng Li Ang Lv Xiuyun Tian Jianhui Wu Hui Qiu Chunyi Hao Source Type: research
Exercise and QUality diet After Leukemia (EQUAL): A randomized weight loss trial among adult survivors of childhood leukemia in the Childhood Cancer Survivor Study
CONCLUSIONS: A remote weight-loss intervention that was successful among adults with CV conditions did not result in significant weight loss among adult survivors of childhood ALL.IMPACT: Future interventions in this population must be tailored to the unique needs of survivors to encourage engagement and adherence.PMID:38652494 | DOI:10.1158/1055-9965.EPI-23-1601 (Source: Cancer Control)
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Danielle Novetsky Friedman Joanne F Chou Jeanne M Clark Chaya S Moskowitz Jennifer S Ford Gregory T Armstrong Nidha Z Mubdi Aaron McDonald Paul C Nathan Charles A Sklar Lakshmi V Ramanathan Leslie L Robison Kevin C Oeffinger Emily S Tonorezos Source Type: research
Human NLRC4 promotes cancer survival and is associated to type-I interferon signaling and immune infiltration
J Clin Invest. 2024 Apr 23:e166085. doi: 10.1172/JCI166085. Online ahead of print.ABSTRACTThe immune system can control cancer progression. However, even though some innate immune sensors of cellular stress are expressed intrinsically in epithelial cells, their potential role in cancer aggressiveness and subsequent overall survival in humans is mainly unknown. Here, we show that NLR family CARD Domain Containing 4 (NLRC4) is downregulated in epithelial tumor cells of colorectal cancer (CRC) patients by using spatial tissue imaging. Strikingly, only the loss of tumor NLRC4 but not stromal is associated with poor immune infi...
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Charlotte Domblides Steven Crampton Hong Liu Juliet M Bartleson Annie Nguyen Claudia Champagne Emily E Landy Lindsey Spiker Christopher Proffitt Sunil Bhattarai Anissa P Grawe Matias Fuentealba Valenzuela Lydia Lartigue Isabelle Mahouche Jeremy Dupaul-Chi Source Type: research
Increased mortality in acromegaly is due to vascular and respiratory disease and is normalised by control of GH levels-A retrospective analysis from the UK Acromegaly Register 1970-2016
CONCLUSION: Acromegaly is associated with increased incidence of all cancers but not thyroid or colon cancer and no increase in cancer mortality. Excess mortality is due to vascular and respiratory disease. The risk is highest in the first 5 years following diagnosis and is mitigated by normalising GH levels.PMID:38652736 | DOI:10.1111/cen.15060 (Source: Cancer Control)
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Steve Orme Richard McNally Peter W James Jessica Davis John Ayuk Claire Higham John Wass UK Acromegaly Register Study Group Source Type: research
The scaffolding protein AKAP12 regulates mRNA localization and translation
Proc Natl Acad Sci U S A. 2024 Apr 30;121(18):e2320609121. doi: 10.1073/pnas.2320609121. Epub 2024 Apr 23.ABSTRACTRegulation of subcellular messenger (m)RNA localization is a fundamental biological mechanism, which adds a spatial dimension to the diverse layers of post-transcriptional control of gene expression. The cellular compartment in which mRNAs are located may define distinct aspects of the encoded proteins, ranging from production rate and complex formation to localized activity. Despite the detailed roles of localized mRNAs that have emerged over the past decades, the identity of factors anchoring mRNAs to subcell...
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Madeleine R Smith Parisa Naeli Seyed M Jafarnejad Guilherme Costa Source Type: research
Immunologic Profiling of Immune-Related Cutaneous Adverse Events with Checkpoint Inhibitors Reveals Polarized Actionable Pathways
CONCLUSIONS: Distinct immunologic ircAE endotypes suggest actionable targets for precision medicine-based interventions.PMID:38652814 | DOI:10.1158/1078-0432.CCR-23-3431 (Source: Cancer Control)
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Mario E Lacouture Elena Goleva Neil Shah Veronica Rotemberg Lukas Kraehenbuehl Kwami F Ketosugbo Taha Merghoub Tara Maier Alexander Bang Stephanie Gu Trina Salvador Andrea P Moy Taras Lyubchenko Olivia Xiao Clifton F Hall Evgeny Berdyshev James Crooks Rya Source Type: research
An analysis of the effects of chronic low dose-rate radiation exposure on cancer focusing on the differences among cancer types
CONCLUSIONS: The analysis showed that the occurrence and mean lifespan are affected in both malignant lymphomas and solid cancers. The shortening of the progression period is only seen in malignant lymphoma, no significant change was observed in solid cancers.PMID:38652836 | DOI:10.1080/09553002.2024.2338551 (Source: Cancer Control)
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Tetsuhiro Kinugawa Ignacia Braga Tanaka Satoshi Tanaka Yuichiro Manabe Fuminobu Sato Takahiro Wada Source Type: research
Trans-Ancestral Genetic Risk Factors for Treatment-Related Type 2 Diabetes Mellitus in Survivors of Childhood Cancer
CONCLUSION: Our findings suggest therapy-related genetic risks contribute to the increased T2D burden among non-Hispanic Black childhood cancer survivors. Additional study of how therapy-related genetic susceptibility contributes to this disparity is needed.PMID:38652878 | DOI:10.1200/JCO.23.02281 (Source: Cancer Control)
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Cindy Im Achal Neupane Jessica L Baedke Brian Lenny Angela Delaney Stephanie B Dixon Eric J Chow Sogol Mostoufi-Moab Tianzhong Yang Melissa A Richard M Monica Gramatges Philip J Lupo Noha Sharafeldin Smita Bhatia Gregory T Armstrong Melissa M Hudson Kirst Source Type: research
The efficacy of artificial intelligence (AI) in detecting interval cancers in the national screening program of a middle-income country
CONCLUSION: This study showed the potential of AI in detecting ICs in initial mammograms and reducing human errors and undetected cancers.PMID:38649312 | DOI:10.1016/j.crad.2024.03.012 (Source: Cancer Control)
Source: Cancer Control - April 22, 2024 Category: Cancer & Oncology Authors: L Çelik E Aribal Source Type: research
Age-stratified analysis reveals arterial thrombosis as a predictor for gender-related second cancers in myeloproliferative neoplasms: a case-control study
Blood Cancer J. 2024 Apr 22;14(1):68. doi: 10.1038/s41408-024-01052-4.NO ABSTRACTPMID:38649342 | DOI:10.1038/s41408-024-01052-4 (Source: Cancer Control)
Source: Cancer Control - April 22, 2024 Category: Cancer & Oncology Authors: Arianna Ghirardi Alessandra Carobbio Paola Guglielmelli Alessandro Rambaldi Valerio De Stefano Alessandro M Vannucchi Ayalew Tefferi Tiziano Barbui Source Type: research
