Recent advances in the role of Yes-associated protein in dermatosis
CONCLUSIONS: The effects of YAP on the skin are complex and require multidimensional investigational approaches. YAP functions as an oncoprotein that can promote the occurrence and development of cancer, but there is currently limited information on the therapeutic potential of YAP inhibition for cancer treatment. Additional studies are also needed to clarify the role of YAP in the development and maturation of dermal fibroblasts; skin barrier function, homeostasis, aging, and melanin production; and dermatosis.PMID:36973973 | DOI:10.1111/srt.13285 (Source: Cell Research)
Source: Cell Research - March 28, 2023 Category: Cytology Authors: Xiaorong Jia Li He Zhi Yang Source Type: research
Reduction of wrinkles: From a computational hypothesis to a clinical, instrumental, and biological proof
CONCLUSIONS: We provide an in vivo demonstration of the anti-ageing benefit of glycerol at high dose (20%) reflected by a cumulative skin surface softening effect. The use of high moisturizing potent formulations should bring additional performance to other conventional moisturizing formulations.PMID:36973988 | DOI:10.1111/srt.13267 (Source: Cell Research)
Source: Cell Research - March 28, 2023 Category: Cytology Authors: Roberto Santoprete Virginie Hourblin Aude Foucher Olivia Dufour Dominique Bernard Yegor Domanov Bernard Querleux Anne Potter Source Type: research
ATP supplementation suppresses UVB-induced photoaging in HaCaT cells via upregulation of expression of SIRT3 and SOD2
CONCLUSIONS: ATP supplementation can suppress UVB irradiation-induced photoaging in HaCaT cells via upregulation of expression of SIRT3 and SOD2.PMID:36973992 | DOI:10.1111/srt.13303 (Source: Cell Research)
Source: Cell Research - March 28, 2023 Category: Cytology Authors: Chunxia Gan Titi Liu Xiaorong Jia Xueqin Huang Xiangdong Qin Xuanjun Wang Jun Sheng Huanhuan Xu Source Type: research
Effects of prolonged stimulation with heated tobacco products (Ploom TECH < sup > + < /sup > ) on gingival epithelial cells
CONCLUSION: Long-term HTP stimulation affected epithelial differentiation and keratinization of gingival epithelial cells. Thus, habitual use of Ploom TECH+ may be a risk factor for tobacco-related oral mucosal diseases.PMID:36974375 | DOI:10.1111/jre.13123 (Source: Cell Research)
Source: Cell Research - March 28, 2023 Category: Cytology Authors: Osamu Uehara Norihiro Nakamoto Daichi Hiraki Durga Paudel Nodoka Sugiyama Tetsuro Morikawa Koki Yoshida Yutaka Kawano Tsuyoshi Shimo Yasushi Furuichi Hiroko Miura Yoshihiro Abiko Source Type: research
Oxymatrine suppresses colorectal cancer progression by inhibiting NLRP3 inflammasome activation through mitophagy induction in vitro and in vivo
In conclusion, the study demonstrates the oxymatrine anti- CRC activity through its unique role in regulating CRC cell mitophagy and NLRP3 inflammasome levels in vitro and in vivo.PMID:36974424 | DOI:10.1002/ptr.7808 (Source: Cell Research)
Source: Cell Research - March 28, 2023 Category: Cytology Authors: Li Liang Weiliang Sun Xiaoxuan Wei Li Wang Huaqiang Ruan Junchuan Zhang Suyan Li Bi Zhao Mengshi Li Zhengwen Cai Jie'an Huang Source Type: research
Feasibility of Computed Tomography-guided Percutaneous Renal Cryoablation Under Local Anesthesia: A Single Center Experience in Taiwan
CONCLUSION: By using -40°C as the pre-plan tumor coverage, with the aid of coaxial cryoablation and multiplanar reconstruction method, CT-guided percutaneous renal cryoablation under local anesthesia is a safe and effective procedure in patients with many comorbidities.PMID:36974775 | DOI:10.21873/anticanres.16322 (Source: Cell Research)
Source: Cell Research - March 28, 2023 Category: Cytology Authors: Yen-Ting Lin Siu-Wan Hung Ming-Cheng Liu Kun-Yuan Chiu Jyh-Wen Chai Jin-Ching Lin Source Type: research
Recent Advances in the Management of Small Cell Carcinoma of the Uterine Cervix
CONCLUSION: Etoposide and platinum tend to have a better prognosis compared to other regimens used for other subtypes of cervical cancer. For recurrent cervical SCNEC, treatment options for patients are very limited. The application of molecular testing for targeted mutations may suggest potential future therapies that may be useful in this disease.PMID:36974776 | DOI:10.21873/anticanres.16288 (Source: Cell Research)
Source: Cell Research - March 28, 2023 Category: Cytology Authors: A I Miyoshi Yutaka Ueda Tomoko Kurita Tadashi Kimura Kiyoshi Yoshino Source Type: research
Real-world Data Study of the Efficacy and Toxicity of Nivolumab < em > vs < /em > . Cetuximab and Predictors of Response to Nivolumab in Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck in a European Population
CONCLUSION: Effectiveness of nivolumab in terms of OS remains superior to cetuximab. OS, PFS and severe or any grade AEs were superior in both arms of our study compared to those in clinical trials. The AEs profile of nivolumab differed in our study from that in the clinical trials' observations. We have identified four statistically significant prognostic variables on the response to nivolumab in R/M HNSCC.PMID:36974777 | DOI:10.21873/anticanres.16320 (Source: Cell Research)
Source: Cell Research - March 28, 2023 Category: Cytology Authors: Lola Macia-Rivas Clara Luz Fernandez-Laguna Cristina Alvarez-Asteinza Ivan Maray Monica Carbajales-Alvarez Ana Lozano-Blazquez Source Type: research
Elevation of the Neutrophil-to-Lymphocyte Ratio Is a Significant Postoperative Poor Prognostic Factor in Patients With Clinical T3-4 Centrally Located Primary Lung Cancer
CONCLUSION: High NLR and CEA positivity were significant poor prognostic factors in patients with cT3-4 CLNSCLC, and only high NLR was an independent predictor. Our findings may be helpful in selecting optimal treatments for advanced CLNSCLC.PMID:36974781 | DOI:10.21873/anticanres.16313 (Source: Cell Research)
Source: Cell Research - March 28, 2023 Category: Cytology Authors: Takuma Tsukioka Nobuhiro Izumi Hiroaki Komatsu Hidetoshi Inoue Ryuichi Ito Satoshi Suzuki Noritoshi Nishiyama Source Type: research
Life-threatening Airway Complication After Radioactive Iodine Treatment: A Case Report and Review of the Literature
CONCLUSION: Although rare, life-threatening airway complications after radioactive iodine treatment, especially with high dose treatment in patients with remaining thyroid tissue, can occur and these patients should be supervised where these complications can be managed.PMID:36974787 | DOI:10.21873/anticanres.16339 (Source: Cell Research)
Source: Cell Research - March 28, 2023 Category: Cytology Authors: Fredrik Landstr öm Jana Sandberg Johan Reizenstein Source Type: research
Biphenotypic Sinonasal Sarcoma: Case Reports of Diagnostic Findings and Clinical Management of 3 Cases
CONCLUSION: The primary management for BSNS is surgical resection. We recommend discussing the role of postoperative adjuvant radiotherapy 60 Gy/30 fractions/6 weeks in patients who are fit for treatment. In clinical practice, dose levels will be constrained by surrounding normal tissues. At present, the role of systemic anticancer therapy is undefined. A prospective registry of ultra-rare cases may provide an evidence base with which to select optimal treatment strategies for BSNS in the future.PMID:36974788 | DOI:10.21873/anticanres.16308 (Source: Cell Research)
Source: Cell Research - March 28, 2023 Category: Cytology Authors: Yolanda Augustin Shane Zaidi Robin L Jones Charlotte Benson Richard Simcock Cyril Fisher Khin Thway Magnus Hallin Aisha B Miah Source Type: research
Association of < em > STAT3, CYP3A5 < /em > , and < em > ABCG2 < /em > Polymorphisms With Osimertinib-induced Adverse Events in NSCLC Patients
CONCLUSION: STAT3 -1697C>G may be a novel risk factor for osimertinib-induced paronychia in patients with NSCLC.PMID:36974789 | DOI:10.21873/anticanres.16331 (Source: Cell Research)
Source: Cell Research - March 28, 2023 Category: Cytology Authors: Masaaki Tanda Kazuhiro Yamamoto Tomoki Hori Hiroki Nishiguchi Miki Yagi Michiko Shimizu Toru Konishi Tomonori Ozaki Natsue Yoshioka Motoko Tachihara Takefumi Ito Shigeki Ikushima Tomohiro Omura Ikuko Yano Source Type: research
Outcome of Multidisciplinary Treatment of Merkel Cell Carcinoma of the Hand and Wrist
CONCLUSION: MCC is a rare cutaneous neuroendocrine carcinoma with a high propensity for regional nodal spread. Despite aggressive local treatment, adjuvant radiotherapy to the primary site and regional nodes, MCC of the hand and wrist has a high rate of recurrence and mortality within five years of diagnosis.PMID:36974790 | DOI:10.21873/anticanres.16304 (Source: Cell Research)
Source: Cell Research - March 28, 2023 Category: Cytology Authors: Samuel E Broida Kareme D Alder Xiao T Chen Steven L Moran Matthew T Houdek Source Type: research
Evaluation of the M371-Test Under Real-life Conditions for Diagnosis and Follow Up of Testicular Germ Cell Tumors
CONCLUSION: Under real life conditions performed on the real-time Thermocycler Rotor-GeneQ (Qiagen) platform, the M371-Test shows an outstanding performance and is far beyond the sensitivity of the classical markers for detecting GCTs and in the follow-up of patients after GCT, especially in seminomas.PMID:36974797 | DOI:10.21873/anticanres.16316 (Source: Cell Research)
Source: Cell Research - March 28, 2023 Category: Cytology Authors: Stefan Pycha Carolina D'Elia Christine Mian Christine Schwienbacher Esther Hanspeter Margherita Palermo Armin Pycha Hansj örg Danuser Emanuela Trenti Source Type: research
Positive p16 Immunostaining Is an Independent Prognostic Variable for Disease-free Survival and Overall Survival in Patients With Squamous Cell Carcinoma of the Vulva Treated With Radical Surgery and Inguinofemoral Lymphadenectomy: An Italian Single Center Retrospective Study
CONCLUSION: p16 expression was detected in 24.4% of patients with VSCC and was found to be an independent prognostic variable for both DFS and OS.PMID:36974801 | DOI:10.21873/anticanres.16315 (Source: Cell Research)
Source: Cell Research - March 28, 2023 Category: Cytology Authors: Angiolo Gadducci Enrico Simonetti Stefania Cosio Antonio Fanucchi Valentina Dolci Concetta Laliscia Antonio Giuseppe Naccarato Sabina Pistolesi Source Type: research
