Resveratrol attenuates mast cell mediated allergic reactions: potential for use as a nutraceutical in allergic diseases?
This article is protected by copyright. All rights reserved.PMID:35598149 | DOI:10.1002/mnfr.202200170 (Source: Cell Research)
Source: Cell Research - May 22, 2022 Category: Cytology Authors: Mehtap Civelek Sabrina Bilotta Axel Lorentz Source Type: research

Cuprizone-mediated demyelination reversibly degrades voiding behavior in mice while sparing brainstem reflex
J Neurosci Res. 2022 May 20. doi: 10.1002/jnr.25065. Online ahead of print.ABSTRACTMultiple sclerosis (MS) is a chronic, progressively debilitating demyelinating disease of the central nervous system (CNS). Nearly 80% of MS patients experience lower urinary tract dysfunction early in their diagnosis. This significantly affects the quality of life, and in latter stages of disease is a leading cause of hospitalization. Previously, animal models have shown that inflammatory demyelination in the CNS causes profound bladder dysfunction, but the confounding influence of systemic inflammation limits the potential interpretation o...
Source: Cell Research - May 21, 2022 Category: Cytology Authors: Ramalakshmi Ramasamy Cara C Hardy Stephen J Crocker Phillip P Smith Source Type: research

RPL38 knockdown inhibits the inflammation and apoptosis in chondrocytes through regulating METTL3-mediated SOCS2 m6A modification in osteoarthritis
CONCLUSION: RPL38 knockdown inhibited osteoarthritic chondrocyte dysfunction and alleviated OA progression through promoting METTL3-m6A-mediated SOCS2 expression.PMID:35596790 | DOI:10.1007/s00011-022-01579-x (Source: Cell Research)
Source: Cell Research - May 21, 2022 Category: Cytology Authors: Liang Shi Hongbo Hu Pengxiao Sun Zheng Li Le Ji Shizhang Liu Jianxin Zhang Source Type: research

Expression of the relaxin family peptide 4 receptor by enterochromaffin cells of the mouse large intestine
Cell Tissue Res. 2022 May 21. doi: 10.1007/s00441-022-03635-8. Online ahead of print.ABSTRACTThe gastrointestinal hormone, insulin-like peptide 5 (INSL5), is found in large intestinal enteroendocrine cells (EEC). One of its functions is to stimulate nerve circuits that increase propulsive activity of the colon through its receptor, the relaxin family peptide 4 receptor (RXFP4). To investigate the mechanisms that link INSL5 to stimulation of propulsion, we have determined the localisation of cells expressing Rxfp4 in the mouse colon, using a reporter mouse to locate cells expressing the gene. The fluorescent signal indicati...
Source: Cell Research - May 21, 2022 Category: Cytology Authors: Ada Koo Ruslan V Pustovit Orla R M Woodward Jo E Lewis Fiona M Gribble Mohammed Akhter Hossain Frank Reimann John B Furness Source Type: research

Using a testis regeneration model, FGF9, LIF, and SCF improve testis cord formation while RA enhances gonocyte survival
Cell Tissue Res. 2022 May 21. doi: 10.1007/s00441-022-03641-w. Online ahead of print.ABSTRACTImplantation of testis cell aggregates from various donors under the back skin of recipient mice results in de novo formation of testis tissue. We used this implantation model to study the putative in vivo effects of six different growth factors on testis cord development. Recipient mice (n = 7/group) were implanted with eight neonatal porcine testis cell aggregates that were first exposed to a designated growth factor: FGF2 at 1 µg/mL, FGF9 at 5 µg/mL, VEGF at 3.5 µg/mL, LIF at 5 µg/mL, SCF at 3.5 µg/mL, retinoic acid (RA) at...
Source: Cell Research - May 21, 2022 Category: Cytology Authors: Awang Hazmi Awang-Junaidi Mohammad Amin Fayaz Savannah Goldstein Ali Honaramooz Source Type: research

Nuclear receptor Nr1d1 alleviates asthma by abating GATA3 gene expression and Th2 cell differentiation
In this study, we found that Nr1d1 plays a decisive role in T helper (Th)-cell polarization and transcriptionally impedes the formation of Th2 cells by directly binding to the promoter region of GATA binding protein 3 (GATA3) gene. Nr1d1 interacts with its cellular companion, the nuclear receptor corepressor and histone deacetylase 3 to form a stable repression complex on the GATA3 promoter. The presence of Nr1d1 also imparts protection against associated inflammatory responses in murine model of asthma and its ligand SR9011 eased disease severity by suppressing Th2 responses. Moreover, Chip-seq profiling uncovered Nr1d1 i...
Source: Cell Research - May 21, 2022 Category: Cytology Authors: Drishti Tiwari Nancy Ahuja Sumit Kumar Rashi Kalra Ravikanth Nanduri Shalini Gupta Asheesh Kumar Khare Ella Bhagyaraj Rashmi Arora Pawan Gupta Source Type: research

Effect of flunixin meglumine on pain-related behaviours following cautery disbudding in dairy goat kids
Vet Res Commun. 2022 May 21. doi: 10.1007/s11259-022-09938-z. Online ahead of print.ABSTRACTThe aim of this research was to evaluate the physiological and behavioural parameters in Saanen goat kids treated with flunixin meglumine compared with no analgesic treatment after cautery disbudding using a device fueled by propane gas. At 7 days of age, 30 goat kids were randomly allocated to three groups: Sham (Sh) control, (i.e., simulating disbudding); Disbudding (Di), using thermal cauterization; Disbudding + Flunixin (DiFl), thermal cauterization + flunixin meglumine (2.2 mg/kg body weight, 15 min before treatment). Each kid ...
Source: Cell Research - May 21, 2022 Category: Cytology Authors: Gabriela Marcela Mart ínez V íctor Humberto Suárez Melissa Hempstead Emilio Alfaro Luis Colque Caro Jos é Alfaro Source Type: research

Oral dysbiosis and its linkage with SARS-CoV-2 infection
Microbiol Res. 2022 May 4;261:127055. doi: 10.1016/j.micres.2022.127055. Online ahead of print.ABSTRACTThe human oral cavity harbours complex microbial communities with various commensal microorganisms that play pivotal roles in maintaining host health and immunity but can elicit local and systemic diseases. The role of commensal microorganisms in SARS-CoV-2 infection and disease susceptibility and enrichment of opportunistic pathobionts in the oral cavity is poorly understood. The present study aims to understand the altered landscape of the oral microbiome and mycobiome in SARS-CoV-2 infected patients (n = 30) and its co...
Source: Cell Research - May 21, 2022 Category: Cytology Authors: Abhishek Gupta Shivang Bhanushali Avinash Sanap Madhura Shekatkar Avinash Kharat Chandrashekhar Raut Ramesh Bhonde Yogesh Shouche Supriya Kheur Avinash Sharma Source Type: research

Rhein: A novel antibacterial compound against Streptococcus mutans infection
Microbiol Res. 2022 May 7;261:127062. doi: 10.1016/j.micres.2022.127062. Online ahead of print.ABSTRACTStreptococcus mutans (S. mutans) is considered the main causative agent of dental caries. The study aims to evaluate the antimicrobial activity of a natural plant product, pure 4,5''-dihydroxy-anthraquinone-2-carboxylic acid (Rhein) against S. mutans. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay was used to determine the viability of immortalized human keratinocytes (HaCaT) following treatment with Rhein. Assay for antimicrobial activity and the time-killing test were performed to evaluate R...
Source: Cell Research - May 21, 2022 Category: Cytology Authors: Veronica Folliero Federica Dell'Annunziata Emanuela Roscetto Alessandra Amato Roberta Gasparro Carla Zannella Vincenzo Casolaro Anna De Filippis Maria Rosaria Catania Gianluigi Franci Massimiliano Galdiero Source Type: research

miR-4742-5p promotes invasiveness of gastric cancer via targeting Rab43: An in  vitro study
Biochem Biophys Res Commun. 2022 May 14;613:180-186. doi: 10.1016/j.bbrc.2022.05.044. Online ahead of print.ABSTRACTmiRNA (miR)-4742-5p is a recently identified microRNA regarding progression and metastasis in gastric cancer (GC). However, the biological function of this novel miRNA is largely unknown. We identified that the miR-4742-5p expression level was variably increased in GC cell lines. Suppression of miR-4742-5p using miR-inhibitor reduced the proliferation, migration, and invasion of GC cells with high miR-4742-5p expression, whereas overexpression of miR-4742-5p-mimic enhanced the aforementioned properties in GC ...
Source: Cell Research - May 21, 2022 Category: Cytology Authors: Won Jung Bae Kyoung-Jin Woo Ji Mi Ahn Chan-Mo Yang You-Sun Kim Seokhwi Kim Dakeun Lee Source Type: research

Effects of constitutively active IKK β on cardiac development
Biochem Biophys Res Commun. 2022 May 10;614:169-174. doi: 10.1016/j.bbrc.2022.05.019. Online ahead of print.ABSTRACTNF-κB is a major transcription factor regulating cell survival, organ development and inflammation, but its role in cardiac development has been inadequately explored. To examine this function, we generated mice in which IKKβ, an essential kinase for NF-κB activation, was constitutively activated in embryonic cardiomyocytes. For this purpose, we used smooth muscle-22α (SM22α)-Cre mice, which are frequently used for gene recombination in embryonic cardiomyocytes. Embryonic hearts of SM22αCre-CA (constitu...
Source: Cell Research - May 21, 2022 Category: Cytology Authors: Sachiko Sugioka Shinya Ikeda Masayuki Harada Masako Kishihata Isehaq Al-Huseini Takeshi Kimura Noboru Ashida Source Type: research

Activin-A, Growth Differentiation Factor-11 and Transforming Growth Factor- β as predictive biomarkers for platinum chemotherapy in advanced non-small cell lung cancer
CONCLUSION: Within the confines of our study, Activin-A, GDF-11 and TGF-β expression was not a predictor of objective radiological response to chemotherapy or overall survival.PMID:35597155 | DOI:10.1016/j.ctarc.2022.100576 (Source: Cell Research)
Source: Cell Research - May 21, 2022 Category: Cytology Authors: Jennifer Lim Alexander Murphy Stephen Wong Adnan Nagrial Deme Karikios Dariush Daneshvar Rachael McCloy Angela M Steinmann Sandra O'Toole Venessa Chin Source Type: research

Effects of ammonia on electrochemical active biofilm in microbial electrolysis cells for synthetic swine wastewater treatment
This study systematically examined the influences of high ammonia loading on MEC performances, bio-community and anode electrochemical activities, and evaluated practical feasibility and application inch of MECs for the energy recovery and pollutant removal of high concentration organic and ammonia wastewater.PMID:35597221 | DOI:10.1016/j.watres.2022.118570 (Source: Cell Research)
Source: Cell Research - May 21, 2022 Category: Cytology Authors: Naiyu Wang Yujie Feng Yunfei Li Lijuan Zhang Jia Liu Nan Li Weihua He Source Type: research

A techno-economic approach for eliminating dye pollutants from industrial effluent employing microalgae through microbial fuel cells: Barriers and perspectives
Environ Res. 2022 May 18:113454. doi: 10.1016/j.envres.2022.113454. Online ahead of print.ABSTRACTMicrobial fuel cells are biochemical factories which besides recycling wastewater are electricity generators, if only their low power density can be scaled up. This also adds up to work on many factors responsible to increase the cost of running a microbial fuel cell. As a result, the first step is to use environment friendly dead organic algae biomass or even living algae cells in a microbial fuel cell, also referred to as microalgal microbial fuel cells. This can be a techno-economic aspect not only for treating textile wast...
Source: Cell Research - May 21, 2022 Category: Cytology Authors: Rahul Deka Shristi Shreya Megha Mourya Vandana Sirotiya Anshuman Rai Mohd Jahir Khan Ankesh Ahirwar Benoit Schoefs Muhammad Bilal Ganesh Dattatraya Saratale Justine Marchand Rijuta Ganesh Saratale Sunita Varjani Vandana Vinayak Source Type: research

p53 missense mutant G242A subverts natural killer cells in sheltering mouse breast cancer cells against immune rejection
Exp Cell Res. 2022 May 18:113210. doi: 10.1016/j.yexcr.2022.113210. Online ahead of print.ABSTRACTCancer cells acquire immunoediting ability to evade immune surveillance and thus escape eradication. It is widely known that mutant proteins encoded from tumor suppressor TP53 exhibit gain-of-function in cancer cells, thereby promoting progression; however, how mutant p53 contributes to the sheltering of cancer cells from host anticancer immunity remains unclear. Herein, we report that murine p53 missense mutation G242A (corresponding to human G245A) suppresses the activation of host natural killer (NK) cells, thereby enabling...
Source: Cell Research - May 21, 2022 Category: Cytology Authors: Mohammad B Uddin Kartik R Roy Ronald A Hill Sagor C Roy Xin Gu Li Li Qian-Jin Zhang Zongbing You Yong-Yu Liu Source Type: research