Encapsulation of copper phenanthroline within horse spleen apoferritin: characterisation, cytotoxic activity and ability to retain temozolomide
RSC Adv. 2024 Apr 29;14(20):14008-14016. doi: 10.1039/d3ra07430g. eCollection 2024 Apr 25.ABSTRACTProtein capsules are promising drug delivery vehicles for cancer research therapies. Apoferritin (AFt) is a self-assembling 12 nm diameter hollow nanocage with many desirable features for drug delivery, however, control of drug retention inside the protein cage remains challenging. Here we report the encapsulation of copper(ii)-1,10-phenanthroline (Cu(phen)) within the horse spleen AFt (HSAFt) nanocage, by diffusion of the metal through the pores between the protein subunits. Transmission electron microscopy revealed the forma...
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Maria Letizia Cassioli Michael Fay Lyudmila Turyanska Tracey D Bradshaw Neil R Thomas Anca Pordea Source Type: research
Characterization of tongue coating microbiome from patients with colorectal cancer
CONCLUSION: These results elucidate the use of tongue coating microbiome in CRC patients firstly, and the fur-types observed contribute to a better understanding of the microbial community in human. Furthermore, the tongue coating microbiota-based biomarkers provide a valuable reference for CRC prediction and diagnosis.PMID:38686186 | PMC:PMC11057396 | DOI:10.1080/20002297.2024.2344278 (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Qubo Chen Xiaoting Huang Haiyan Zhang Xuanting Jiang Xuan Zeng Wanhua Li Hairong Su Ying Chen Fengye Lin Man Li Xiangyu Gu Huihui Jin Ruohan Wang Dechang Diao Wei Wang Jin Li Sufen Wei Weizheng Zhang Wofeng Liu Zhiping Huang Yusheng Deng Wen Luo Zuofeng L Source Type: research
Clinical Phenotype and Disease Course of Inflammatory Bowel Disease in Iran: Results of the Iranian Registry of Crohn's and Colitis (IRCC)
CONCLUSION: In this national registry-based study, there are significant differences in some clinical phenotypes such as the prevalence of extra-intestinal manifestations and treatment strategies such as biological use in different geographical locations.PMID:38685844 | DOI:10.34172/aim.2024.27 (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Bahar Saberzadeh-Ardestani Amir Ali Khosravi Fariborz Mansour-Ghanaei Homayoon Vahedi Nadieh Baniasadi Mohammadreza Seyyedmajidi Baran Parhizkar Ahmad Hormati Sayed Jalalledin Naghshbandi Somaieh Matin Amir Abbas Hassan Zadeh Tarang Taghvaei Mohsen Bahram Source Type: research
Characterization of tongue coating microbiome from patients with colorectal cancer
CONCLUSION: These results elucidate the use of tongue coating microbiome in CRC patients firstly, and the fur-types observed contribute to a better understanding of the microbial community in human. Furthermore, the tongue coating microbiota-based biomarkers provide a valuable reference for CRC prediction and diagnosis.PMID:38686186 | PMC:PMC11057396 | DOI:10.1080/20002297.2024.2344278 (Source: Journal of Oral Microbiology)
Source: Journal of Oral Microbiology - April 30, 2024 Category: Microbiology Authors: Qubo Chen Xiaoting Huang Haiyan Zhang Xuanting Jiang Xuan Zeng Wanhua Li Hairong Su Ying Chen Fengye Lin Man Li Xiangyu Gu Huihui Jin Ruohan Wang Dechang Diao Wei Wang Jin Li Sufen Wei Weizheng Zhang Wofeng Liu Zhiping Huang Yusheng Deng Wen Luo Zuofeng L Source Type: research
Activation of M2 macrophage autophagy by rapamycin increases the radiosensitivity of colorectal cancer xenografts
CONCLUSIONS: Therefore, autophagy-activated M2 supernatant can downregulate the expression of the antiapoptotic genes Livin and Survivin in CRC xenografts, improving the radiosensitivity of CRC by inducing apoptosis in combination with radiotherapy and inhibiting the growth of transplanted tumors.PMID:38687942 | DOI:10.4103/jcrt.jcrt_215_23 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Lening Shao Yongyou Wu Jianping Cao Fengyun Zhong Xiaodong Yang Chungen Xing Source Type: research
Estimated impact and value of blood-based colorectal cancer screening at varied adherence compared with stool-based screening
Conclusions: Triennial screening with mt-sDNA resulted in better clinical outcomes at a lower cost compared with the modeled blood-based test even at perfect adherence, supporting application of blood-based tests only as a secondary screening option.PMID:38686394 | DOI:10.1080/13696998.2024.2349467 (Source: Journal of Medical Economics)
Source: Journal of Medical Economics - April 30, 2024 Category: Health Management Authors: John B Kisiel A Mark Fendrick Derek W Ebner A Burak Ozbay Vahab Vahdat Chris Estes Paul J Limburg Source Type: research
Colorectal Cancer Incidence in Iran Based on Sex, Age, and Geographical Regions: A Study of 2014-2017 and Projected Rates to 2025
CONCLUSION: The anticipated increase in CRC incidence in Iran emphasizes the need for additional studies to better identify risk factors. Furthermore, implementing screening programs is recommended for individuals at a higher risk of CRC, including men, the elderly population, and those residing in regions with a notable prevalence of CRC.PMID:38685843 | DOI:10.34172/aim.2024.26 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - April 30, 2024 Category: Middle East Health Authors: Hani AziziKia Azin Teymourzadeh Hosein Kouchaki Amin Nakhostin-Ansari Pooya Jafari Doudaran Izadmehr Ahmadinejad Armin Hoveidaei Gholamreza Roshandel Source Type: research
Clinical Phenotype and Disease Course of Inflammatory Bowel Disease in Iran: Results of the Iranian Registry of Crohn's and Colitis (IRCC)
CONCLUSION: In this national registry-based study, there are significant differences in some clinical phenotypes such as the prevalence of extra-intestinal manifestations and treatment strategies such as biological use in different geographical locations.PMID:38685844 | DOI:10.34172/aim.2024.27 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - April 30, 2024 Category: Middle East Health Authors: Bahar Saberzadeh-Ardestani Amir Ali Khosravi Fariborz Mansour-Ghanaei Homayoon Vahedi Nadieh Baniasadi Mohammadreza Seyyedmajidi Baran Parhizkar Ahmad Hormati Sayed Jalalledin Naghshbandi Somaieh Matin Amir Abbas Hassan Zadeh Tarang Taghvaei Mohsen Bahram Source Type: research
Bridging current knowledge gap: better primary colorectal cancer prevention in people living with metabolic dysfunction-associated steatotic liver
(Source: Internal and Emergency Medicine)
Source: Internal and Emergency Medicine - April 30, 2024 Category: Emergency Medicine Source Type: research
Evaluation of the “Burgenland PREvention trial of colorectal cancer Disease with ImmunologiCal Testing” (B-PREDICT)—a population-based colorectal cancer screening program
The colorectal cancer (CRC) screening program B-PREDICT is a population based invited two stage screening project using a faecal immunochemical test (FIT) for initial screening followed by a colonoscopy for th... (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - April 30, 2024 Category: Gastroenterology Authors: Stefanie BREZINA, Gernot LEEB, Andreas BAIERL, Evelyn GR ÄF, Monika HACKL, Philipp HOFER, Harald LANG, Michaela KLEIN, Karl MACH, Remy SCHWARZER, Wilhelm WLASSITS, Andreas PÜSPÖK and Andrea GSUR Tags: Research Source Type: research
Efficacy and Safety of Neoadjuvant Subcutaneous Envafolimab in dMMR/MSI-H Locally Advanced Colon Cancer
ConclusionsEnvafolimab yielded promising surgical outcomes and safety in dMMR/MSI-H locally advanced colon cancer, representing a promising treatment modality for this population. (Source: Targeted Oncology)
Source: Targeted Oncology - April 30, 2024 Category: Cancer & Oncology Source Type: research
Circulating-tumour DNA methylation of HAND1 gene: a promising biomarker in early detection of colorectal cancer
Colorectal cancer (CRC) is one of the significant global health concerns with an increase in cases. Regular screening tests are crucial for early detection as it is often asymptomatic in the initial stages. Li... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - April 30, 2024 Category: Genetics & Stem Cells Authors: Mehrdad Shavali, Arash Moradi, Mohammad Tahmaseb, Kamal Mohammadian and Shahla Mohammad Ganji Tags: Research Source Type: research
The utility of synoptic operation reports in colorectal surgery: a systematic review
ConclusionsSR offer advantages in completeness, data extraction, and communication compared to NR. Surgeons perceive them as beneficial for research, quality improvement, and teaching. This review supports the necessity for development of user-friendly SR that seamlessly integrate into pre-existing EMRs, optimising patient care and enhancing the quality of CRC surgical documentation. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - April 30, 2024 Category: Gastroenterology Source Type: research
Cancers, Vol. 16, Pages 1756: Interventional Treatments of Colorectal Liver Metastases Using Thermal Ablation and Transarterial Chemoembolization: A Single-Center Experience over 26 Years
li
Hamzah Adwan
The aim of this study was to analyze the long-term results of different locoregional treatments for colorectal cancer liver metastases (CRLM), including transarterial chemoembolization (TACE), laser-induced thermotherapy (LITT) and microwave ablation (MWA). A total of 2140 patients with CRLM treated at our department between 1993 and 2020 were included in this retrospective study. The patients were divided into the following groups: LITT (573 patients; median age: 62 years), TACE + LITT (346 patients; median age: 62 years), MWA (67 patients; median age: 59 years), TACE + MWA (152 patients; median age:...
Source: Cancers - April 30, 2024 Category: Cancer & Oncology Authors: Thomas J. Vogl Jason Freichel Tatjana Gruber-Rouh Nour-Eldin Abdelrehim Nour-Eldin Wolf-Otto Bechstein Stefan Zeuzem Nagy N. N. Naguib Ulrich Stefenelli Hamzah Adwan Tags: Article Source Type: research
Principles of risk assessment in colon cancer: immunity is key
Volume 13, Issue 1, December 2024 . (Source: OncoImmunology)
Source: OncoImmunology - April 30, 2024 Category: Cancer & Oncology Authors: Assia HijaziJ érôme Galona INSERM, Laboratory of Integrative Cancer Immunology, Paris, Franceb Equipe Labellisée Ligue Contre le Cancer, Paris, Francec Centre de Recherche des Cordeliers, Sorbonne Université, Université Paris Cité, Paris, Franced Ve Source Type: research
