The need for surgery in pediatric patients with inflammatory bowel disease treated with biologicals
ConclusionDespite initiation of biological treatment, the risk of intestinal surgery remains high in pediatric IBD patients and often the need for surgery emerges after the transition to adult IBD clinics. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - April 25, 2024 Category: Gastroenterology Source Type: research

External validation of the colorectal cancer risk score LiFeCRC using food frequency questions in the HUNT study
ConclusionReadily available clinical variables and food frequency questions in a modified LiFeCRC score can identify patients at risk of CRC and may improve primary prevention by motivating to lifestyle change or participation in the CRC screening programme. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - April 25, 2024 Category: Gastroenterology Source Type: research

Evaluation of anorectal function using real-time tissue elastography before and after preoperative chemoradiotherapy
ConclusionInternal anal sphincter sclerosis due to chemoradiotherapy may correlate to anorectal dysfunction. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - April 25, 2024 Category: Gastroenterology Source Type: research

Efficacy of electroacupuncture therapy in patients with functional anorectal pain: study protocol for a multicenter randomized controlled trial
DiscussionResults of this trial will be contributed to further clarify the value of electroacupuncture at Baliao acupoint as a treatment for FAP in the clinic.Trial registrationThis trial has been registered in Chinese Clinical Trial Registry  https://www.chictr.org.cn/ (ChiCTR2300069757) on March 24, 2023. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - April 22, 2024 Category: Gastroenterology Source Type: research

Conditional survival analysis and real-time prognosis prediction in stage III T3 –T4 colon cancer patients after surgical resection: a SEER database analysis
ConclusionsOur study developed nomograms and predictive models for postoperative stage III survival in T3 –T4 colon cancer with the aim of accurately estimating conditional survival. Survival bias in our analyses may lead to overestimation of survival outcomes, which may limit the applicability of our findings. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - April 19, 2024 Category: Gastroenterology Source Type: research

Bowel preparation for elective colorectal resection: multi-treatment machine learning analysis on 6241 cases from a prospective Italian cohort
ConclusionsMoABP significantly reduced the SSI risk after elective colorectal surgery, therefore representing a valid alternative to NBP. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - April 16, 2024 Category: Gastroenterology Source Type: research

Reply to the letter to the editor regarding “A prospective randomized study of multimodal analgesia combined with single injection transversus abdominis plane block versus epidural analgesia against postoperative pain after laparoscopic colon cancer surgery”
(Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - April 16, 2024 Category: Gastroenterology Source Type: research

Two-row, three-row or powered circular stapler, which to choose when performing colorectal anastomosis? A systematic review and meta-analysis
ConclusionPCS presented a significantly lower risk of leakage and anastomotic bleeding while TRCS only demonstrated a risk reduction in AL. Risk difference of AL was superior in the PCS than in TRCS. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - April 12, 2024 Category: Gastroenterology Source Type: research

Is there a link between appendicitis and the risk of diverticular disease?: a large German cohort study
ConclusionThis large-scale population-based study provides valuable insights into the interaction between appendicitis and diverticular disease. The study underscores the need for further research elucidating the underlying mechanisms linking appendicitis to diverticular disease. Probiotics emerge as a potential therapeutic avenue warranting exploration in the management of both conditions. These findings have important implications for clinical practice, highlighting the importance of considering appendicitis as a potential risk factor for diverticular disease, particularly in men. Further investigation is warranted to va...
Source: International Journal of Colorectal Disease - April 10, 2024 Category: Gastroenterology Source Type: research

Minor impact of anastomotic leakage in anterior resection for rectal cancer on long-term male urinary and sexual function
ConclusionAnastomotic leakage after anterior resection had a minor negative impact on urinary and sexual function in men. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - April 9, 2024 Category: Gastroenterology Source Type: research

Analysis of the differential expression of serum miR-21-5p, miR-135-5p, and miR-155-5p by Bifidobacterium triplex viable capsules during the perioperative stage of colorectal cancer
ConclusionRadical surgery reduces the levels of serum miR-21-5p, miR-135-5p, and miR-155-5p expression in patients with CRC. The use of Bifidobacterium triplex viable capsules assists in achieving quicker perioperative recovery from radical surgery in CRC patients, and this underlying mechanism may be associated with the regulation of serum miR-21-5p, miR-135-5p, and miR-155-5p expression levels. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - April 7, 2024 Category: Gastroenterology Source Type: research

Systematic review and meta-analysis of the management of acute uncomplicated diverticulitis: time to change traditional practice
ConclusionObservation-only treatment is feasible and safe in selected clinically stable patients with uncomplicated acute diverticulitis (Hinchey 1a classification). It may provide better outcomes including decreased length of hospital stay. Moreover, the OP approach in treating patients with Hinchey 1a acute diverticulitis is comparable to IP management. Future high-quality randomised controlled studies are needed to understand the outcomes of the NABX approach used in an OP setting in managing patients with uncomplicated acute diverticulitis. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - April 5, 2024 Category: Gastroenterology Source Type: research

A new clinical model for predicting lymph node metastasis in T1 colorectal cancer
ConclusionsWe developed a clinical prediction model for LNM in T1 CRC using five factors that are easily accessible in clinical practice. The model has better predictive performance and practicality than the current guidelines and can assist clinicians in making treatment decisions for T1 CRC patients. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - April 3, 2024 Category: Gastroenterology Source Type: research