Optimal definition of coagulation syndrome after colorectal endoscopic submucosal dissection: a post hoc analysis of randomized controlled trial
ConclusionClipping closure after colorectal ESD does not reduce the incidence of PECS regardless of the diagnostic criteria. Either localized abdominal pain or inflammatory response might be optimal criteria of PECS (UMIN000027031).Trial registration numberUMIN000027031Date of registrationApril 18, 2017 (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - June 11, 2021 Category: Gastroenterology Source Type: research

A clinical risk analysis of early post-operative delirium after laparoscopic colorectal cancer surgery in elderly patients: a retrospective study
ConclusionOur findings suggest that an older age, sleeping pill medication before surgery, history of cerebrovascular disease, and maximum intraoperative temperature ≥37 °C are independent risk factors of EPOD after laparoscopic colorectal surgery in elderly patients. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - June 11, 2021 Category: Gastroenterology Source Type: research

Interhospital referral of colorectal cancer patients: a Dutch population-based study
This study aims to evaluate characteristics and waiting times of patients with primary colorectal cancer who are referred between hospitals.MethodsData were extracted from the Dutch ColoRectal Audit (2015-2019). Waiting time between first tumor-positive biopsy until first treatment was compared between subgroups stratified for referral status, disease stage, and type of hospital.ResultsIn total, 46,561 patients were included. Patients treated for colon or rectal cancer in secondary care hospitals were referred in 12.2% and 14.7%, respectively. In tertiary care hospitals, corresponding referral rates were 43.8% and 66.4%. R...
Source: International Journal of Colorectal Disease - June 11, 2021 Category: Gastroenterology Source Type: research

Radical lymphadenectomy of a para-aorta lymph node metastasis in colorectal cancer prolongs relapse-free survival
ConclusionOur study suggested that a radical lymphadenectomy for treating PALMs in CRC could be performed safely and could prolong the RFS. More studies are necessary to strengthen the evidence in support of this conclusion. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - June 11, 2021 Category: Gastroenterology Source Type: research

Development and validation of a nomogram for further decision of radical surgery in pT1 colorectal cancer after local resection
AbstractPurposeThe aim of this study was to develop and validate a nomogram to assist physicians making further decisions on the requirement of a radical surgery for T1 colorectal cancer (CRC) after local excision through preoperative prediction of lymph node metastasis (LNM).MethodsA total of 141 T1 CRC patients were enrolled from January 2013 to August 2020. The independent predictive parameters were determined in multivariate analyses. The nomogram was constructed based on predictors of LNM and its performance was evaluated with respect to its calibration, discrimination, and decision curve analysis. Internal validation...
Source: International Journal of Colorectal Disease - June 11, 2021 Category: Gastroenterology Source Type: research

Accuracy and inter-observer agreement of the nice and kudo classifications of superficial colonic lesions: a comparative study
ConclusionThe NICE and the Kudo classifications might be considered comparable. Our data could allow the use of the NBI Kudo classification even in those centers where magnification is not available. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - June 11, 2021 Category: Gastroenterology Source Type: research

Meta-analysis of laparoscopic mesh rectopexy versus posterior sutured rectopexy for management of complete rectal prolapse
AbstractObjectivesTo evaluate comparative outcomes of laparoscopic mesh rectopexy (LMR) and laparoscopic posterior sutured rectopexy (LPSR) in patients with rectal prolapse.MethodsWe conducted a systematic search of electronic databases and bibliographic reference lists with application of a combination of free text and controlled vocabulary search adapted to thesaurus headings, search operators, and limits. Recurrence, Cleveland Clinic Incontinence Score (CCIS), Cleveland Clinic Constipation Score (CCCS), surgical site infections, procedure time, and length of hospital stay were the evaluated outcome measures.ResultsWe id...
Source: International Journal of Colorectal Disease - June 11, 2021 Category: Gastroenterology Source Type: research

Single-incision versus conventional multiport laparoscopic surgery for colorectal cancer: a meta-analysis of randomized controlled trials and propensity-score matched studies
AbstractPurposeTo compare single-incision laparoscopic surgery (SILS) and multiport laparoscopic surgery (MLS) for colorectal cancer in terms of short- and long-term outcomes.MethodsA systematic literature search was performed in PubMed, Web of Science, and Embase. Randomized controlled trials (RCTs) and propensity-score matched (PSM) studies comparing SILS and MLS for colorectal cancer were enrolled. Outcomes of interests included intraoperative, postoperative, pathological, and survival outcomes.ResultsSixteen studies (6 RCTs and 10 PSM studies) published between 2012 and 2020 with a total of 2425 patients were enrolled....
Source: International Journal of Colorectal Disease - June 11, 2021 Category: Gastroenterology Source Type: research

Enteral resorbable diet versus standard diet in primary sphincter reconstruction: a prospective randomised trial
This study was aimed to assess any differences between a standard diet (SD) and the enteral resorbable diet (ED) in terms of operative outcomes and patient tolerance after fistulectomy with primary sphincter reconstruction.MethodAdult patients undergoing elective fistulectomy with primary sphincter reconstruction for anorectal and rectovaginal fistulas were eligible for inclusion. Patients were intraoperatively randomised to receive either the ED and peristalsis-inhibiting medication (ED) or a SD. The primary endpoint was the healing rate. Secondary endpoints included continence scores, complications and quality of life. S...
Source: International Journal of Colorectal Disease - June 11, 2021 Category: Gastroenterology Source Type: research

Current evidence regarding the role of adjuvant chemotherapy in rectal cancer patients with pathologic complete response after neoadjuvant chemoradiotherapy: a systematic review and meta-analysis
ConclusionsConsidering the study limitations and the lack of randomized studies, further high-quality RCTs are required to confirm the findings of our study. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - June 11, 2021 Category: Gastroenterology Source Type: research

Karydakis procedure versus Limberg flap for treatment of pilonidal sinus: an updated meta-analysis of randomized controlled trials
AbstractBackgroundThe Karydakis procedure (KP) and Limberg flap (LF) are two commonly performed operations for pilonidal sinus disease (PND). The present meta-analysis aimed to review the outcome of randomized trials that compared KP and LF.MethodsElectronic databases were searched in a systematic manner for randomized trials comparing KP and LF through July 2020. This meta-analysis was reported in line with the PRISMA statement. The main outcome measures were failure of healing of PND, complications, time to healing, time to return to work, and cosmetic satisfaction.ResultsFifteen randomized controlled trials (1943 patien...
Source: International Journal of Colorectal Disease - June 11, 2021 Category: Gastroenterology Source Type: research

Robotic versus laparoscopic ileal pouch-anal anastomosis (IPAA): a systematic review and meta-analysis
ConclusionsAvailable data suggests that the robotic platform is safe to use for IPAA procedures. There is minimal evidence for clinical advantages, but with little data to base decisions and significant potential for improvements in technique and cost-effectiveness, further use of the platform for this operation is warranted. It is vital that this occurs within an evaluation framework. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - June 11, 2021 Category: Gastroenterology Source Type: research

Correction to: Accuracy and inter-observer agreement of the nice and kudo classifications of superficial colonic lesions: a comparative study
A Correction to this paper has been published:https://doi.org/10.1007/s00384-021-03905-x (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - June 11, 2021 Category: Gastroenterology Source Type: research

An analysis of the rates of discontinuation and non-publication of colorectal cancer clinical trials
ConclusionWe found that more than one-quarter of trials were prematurely ended, and almost one-third of completed trials did not publish their findings. Subjecting trial participants to potentially harmful treatments and interventions that fail to complete or publish study findings have the potential to undermine the patient-provider relationship, as well as public confidence in government-sponsored clinical trials. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - June 10, 2021 Category: Gastroenterology Source Type: research

Visceral adiposity and inflammatory bowel disease
AbstractBackgroundRates of obesity are increasing worldwide, as is the incidence of inflammatory bowel disease (IBD). Obesity is now considered an inflammatory state. Visceral adiposity in particular may be associated with a more severe inflammatory phenotype in IBD.AimThe aim of this review article is to summarise the current literature on the association between visceral adiposity and outcomes in inflammatory bowel diseaseMethodsTo collect relevant articles, PubMed/MEDLINE and Embase searches were performed using Boolean search phrases. Grey literature and manual searches were also performed. Abstracts were selected by t...
Source: International Journal of Colorectal Disease - June 9, 2021 Category: Gastroenterology Source Type: research

An update on surgical treatment of hemorrhoidal disease: a systematic review and meta-analysis
ConclusionThere are multiple favorable techniques without a clear “gold standard” based on current literature. Open discussion should be had between patients and physicians to guide individualized care. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - June 8, 2021 Category: Gastroenterology Source Type: research

Mechanical bowel preparation combined with oral antibiotics in colorectal cancer surgery: a nationwide population-based study
This study aimed to reveal the effect of oral antibiotics combined with mechanical bowel preparation in colorectal surgery.MethodsThis study was a nationwide population-based retrospective study. Data between January 1, 2016, and December 31, 2018, from the Korean National Health Insurance Service database were analyzed. Patients who underwent elective colorectal cancer surgery were included.ResultsA total of 20,740 patients were finally included, comprising 14,554 (70.2%) who underwent mechanical bowel preparation alone and 6186 (29.8%) who underwent mechanical bowel preparation with oral antibiotics. The mechanical bowel...
Source: International Journal of Colorectal Disease - June 5, 2021 Category: Gastroenterology Source Type: research

Long-term outcomes of Hartmann ’s procedure versus primary anastomosis for generalized peritonitis due to perforated diverticulitis: follow-up of a prospective multicenter randomized trial (DIVERTI)
ConclusionsThis follow-up study with a median follow-up time of  >  9 years among living patients indicates that PRA for perforated diverticulitis is associated with fewer long-term complications and better QoL than HP. PRA significantly reduced the incisional hernia rate and the need for reoperation. Long-term survival was not jeopardized by the PRA approach. F uture studies are needed to address the utility of protective stoma. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - June 4, 2021 Category: Gastroenterology Source Type: research

Correction to: CIP2A regulates MYC translation (via its 5 ′UTR) in colorectal cancer
A correction to this paper has been published: https://doi.org/10.1007/s00384-021-03960-4The original version of this article was revised due to a retrospective Open Access order. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - June 4, 2021 Category: Gastroenterology Source Type: research

A probabilistic model for the prediction of intra-abdominal infection after colorectal surgery
ConclusionsWhereas at postoperative day 3, a logistic regression model with imputed data should be used to predict IAI; at day 5, when the predictive ability is almost identical, the Bayesian network model should be used. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - June 3, 2021 Category: Gastroenterology Source Type: research

Robotic versus laparoscopic right colectomy for colon cancer: a nationwide cohort study
AbstractPurposeOn a national level, the minimally invasive approach is widely adopted in Denmark. The adoption of robotic colorectal surgery is increasing; however, the advantage of a robotic approach in right colectomy is still uncertain. The purpose of this study was to compare robotic right colectomy with laparoscopic right colectomy on a national level.MethodsThis was a nationwide database study based on data from the Danish Colorectal Cancer Group database. Patients from all colorectal centers in Denmark in the period 2014 –2018 treated with curative intend in an elective setting with either robotic or laparosco...
Source: International Journal of Colorectal Disease - June 2, 2021 Category: Gastroenterology Source Type: research

Letter to the Editor regarding “Prophylactic subcutaneous drainage reduces post-operative incisional infections in colorectal surgeries: a meta-analysis of randomized controlled trials”
(Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - June 1, 2021 Category: Gastroenterology Source Type: research

Risk and prognostic nomograms for colorectal neuroendocrine neoplasm with liver metastasis: a population-based study
ConclusionsThis research identified the risk and prognostic factors in colorectal NENs patients with LM. The nomograms constructed by this study can be convenient tools for facilitating clinical decision-making. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - June 1, 2021 Category: Gastroenterology Source Type: research

Ileo-colic intra-corporeal anastomosis during robotic right colectomy: a systematic literature review and meta-analysis of different techniques
ConclusionsICA fashioning during RRC can be accomplished with several technical variants without evidence of a clear superiority of anyone of these techniques. Although the use of robotic staplers could be associated with some benefits, further studies are necessary to draw conclusions. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - May 14, 2021 Category: Gastroenterology Source Type: research

Sarcopenia predicts worse postoperative outcomes and decreased survival rates in patients with colorectal cancer: a systematic review and meta-analysis
ConclusionAmong patients with colorectal cancer, sarcopenia is a strong predictor of increased postoperative complications and worse survival outcomes. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - May 14, 2021 Category: Gastroenterology Source Type: research

The optimal management of anti-drug antibodies to infliximab and identification of anti-drug antibody values for clinical outcomes in patients with inflammatory bowel disease
AbstractPurposeSecondary loss of response (LOR) to infliximab (IFX) commonly occurs. One cause is the development of anti-drug antibodies (ADAs). Evidence regarding the optimal management of ADAs is lacking. We aim to identify the best practice of management of ADAs to IFX to avoid discontinuation of therapy and to determine specific ADA cut-off values to determine pre-specified clinical outcomes.MethodsThis is a 3-year study of patients receiving IFX who developed ADAs> 8 μg/ml. We reviewed the management strategies and subsequent outcomes in patients who developed ADAs.ResultsA total of 132 patients are included. B...
Source: International Journal of Colorectal Disease - May 14, 2021 Category: Gastroenterology Source Type: research

A European snapshot of psychosocial characteristics and patients ’ perspectives of faecal incontinence — do they correlate with current scoring systems?
AbstractPurposeTo compare the current clinical scoring systems used to quantify the severity of symptoms of faecal incontinence (FI) to patients ’ subjective scoring of parameters of psychosocial well-being.MethodsPatients referred to six European centres for investigation or treatment of symptoms of FI between June 2017 and September 2019 completed a questionnaire that captured patient demographics, incontinence symptoms using St. Mark ’s Incontinence score (SMIS) and ICIQ-B, psychological well-being (HADS, Hospital Anxiety and Depression Scale), and social interaction (a three-item loneliness scale).ResultsTh...
Source: International Journal of Colorectal Disease - May 14, 2021 Category: Gastroenterology Source Type: research

Targeted housestaff intervention reduces opioid use without worsening patient-reported pain scores and improves outcomes among patients with IBD: the “IBD pain ladder”
AbstractBackground and AimsOpioid analgesic use is associated with increased mortality, higher readmission rates, and reduced quality of life among patients with inflammatory bowel disease (IBD). With the goal of reducing inpatient opioid use among patients with IBD admitted to our inpatient gastroenterology (GI) service, we designed and implemented a standardized, educational intervention providing analgesic decision support to internal medicine and emergency medicine housestaff at our institution.MethodsPre-intervention data was collected from patients admitted during a 9-month period prior to intervention. Post-interven...
Source: International Journal of Colorectal Disease - May 14, 2021 Category: Gastroenterology Source Type: research

Risk factors affecting failure of colonoscopic detorsion for sigmoid colon volvulus: a single center experience
ConclusionsCD failure rate was significantly associated with previous abdominal surgery and a cecum diameter over 10 cm. We found that patients with these factors will tend to need more emergency surgery. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - May 14, 2021 Category: Gastroenterology Source Type: research

Clinical characteristics and prognostic factors of colorectal cancer patients with ovarian metastasis: a multicenter retrospective study
ConclusionsThis nomogram could be a promising tool to help clinicians to estimate individual survival outcome of patients with OMCRC. Further study is warranted to validate the practicality of this model. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - May 14, 2021 Category: Gastroenterology Source Type: research

Does rectal tube/transanal stent placement after an anterior resection for rectal cancer reduce anastomotic leak? A systematic review and meta-analysis
AbstractBackgroundThere is increasing evidence that either a transanal stent (TAS) or rectal tube (RT) can decrease the risk of anastomotic leakage (AL) after anterior resection for rectal cancer, in which a diverting stoma may not be required.ObjectivesThe aim of this review was to investigate the efficacy and safety of RT/TAS in preventing AL after anterior resections.Data sourcesAn up-to-date systematic review was performed on the available literature between 2000 and 2020 on PubMed, EMBASE, Medline and Cochrane Library databases.Study selectionAll studies reporting on anterior resections in adults, comparing transanal ...
Source: International Journal of Colorectal Disease - May 14, 2021 Category: Gastroenterology Source Type: research

Defining early recurrence in patients with resected primary colorectal carcinoma and its respective risk factors
AbstractPurposeThere is no evidence-based definition of early recurrence following resection of colorectal cancer. The purpose of this study is to define a point that discriminates between early and late recurrence in patients who have undergone colorectal cancer resection with curative intent and to analyze associated risk factors.MethodsA retrospective single-center cohort study was performed at a university hospital recognized as a comprehensive cancer center, specializing in colorectal cancer surgery. Patient data were retrieved from a prospectively maintained institutional database. Included patients underwent resecti...
Source: International Journal of Colorectal Disease - May 14, 2021 Category: Gastroenterology Source Type: research

Treatment and subsequent prognosis in locally recurrent rectal cancer: a multicenter retrospective study of 498 patients
ConclusionsThis large-scale cohort study showed that surgical resection led to a favorable prognosis compared to other treatments for LRRC. Therefore, surgical resection should be considered whenever feasible for LRRC patients. In addition, undifferentiated type, T4, and tumor marker (CEA and CA19 –9) elevation were identified as independent prognostic factors for OS among patients with LRRC. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - May 14, 2021 Category: Gastroenterology Source Type: research

Sclerotherapy with 3% polidocanol foam for third- and fourth-degree hemorrhoids as “bridge treatment” during the COVID-19 pandemic in Italy
ConclusionsThis treatment could reduce the bleeding that is the main symptom from which patients suffer and for which they underwent proctological evaluation and surgery. According to our preliminary experience in the impossibility of accessing the surgery during the COVID-19 pandemic, ST could be considered as the treatment of choice in those patients who are suffering from grade III- and IV-degree hemorrhoids while waiting for surgery. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - May 14, 2021 Category: Gastroenterology Source Type: research

Right-side colectomy with complete mesocolic excision vs conventional right-side colectomy in the treatment of colon cancer: a systematic review and meta-analysis
ConclusionComplete mesocolic excision of the right-side colectomy improves oncological outcomes without increasing mortality and morbidity rates compared to standard right-side hemicolectomy. CME should therefore be routinely performed in the treatment of right-side colon cancer. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - May 13, 2021 Category: Gastroenterology Source Type: research

False-positive fecal immunochemical test results in colorectal cancer screening and gastrointestinal drug use
AbstractPurposeThe study aimed to determine the influence of drug treatments (proton pump inhibitors [PPIs] combined with other drugs) on the false-positive (FP) rate in the fecal immunochemical test (FIT).MethodsPatients undergoing colonoscopy in the setting of a CRC screening program due to a positive FIT result were included prospectively. Demographic data and drug intake of PPIs, antiplatelet therapy (APA), anticoagulants, selective serotonin reuptake inhibitors (SSRIs), and nonsteroidal anti-inflammatory drugs (NSAIDs) were collected. An FP FIT result was considered normal colonoscopy or with nonneoplastic pathology (...
Source: International Journal of Colorectal Disease - May 12, 2021 Category: Gastroenterology Source Type: research

Prediction of the postoperative 90-day mortality after acute colorectal cancer surgery: development and temporal validation of the ACORCA model
ConclusionWe developed prediction model for 90-day mortality after acute colorectal cancer surgery that may be a promising tool for surgeons to identify patients at risk of postoperative mortality. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - May 12, 2021 Category: Gastroenterology Source Type: research

Reducing hospital stay for colorectal surgery in ERAS setting by means of perioperative patient education of expected day of discharge
AbstractPurposeDespite the enhanced recovery after surgery (ERAS) protocol, length of stay (LOS) after colorectal surgery varies considerably. The majority of longer admissions is often not medically necessary. We aimed to investigate possible reduction of LOS by perioperative education with an expected discharge date (EDD).MethodsThis single-centre retrospective study included 578 patients who underwent surgery for colorectal cancer in 2016 with standard care (ERAS) and in 2018 with the addition of EDD education program (ERAS+). A comparison was made of a 1-year period prior to and following the implementation of EDD. The...
Source: International Journal of Colorectal Disease - May 11, 2021 Category: Gastroenterology Source Type: research

State-of-the-art colorectal disease: postoperative ileus
ConclusionThe results of different studies are often contradictory, as a concise definition of POI and reliable surrogate endpoints are still absent. These will be needed to advance POI research and provide clinicians with consistent data to improve the treatment strategies. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - May 11, 2021 Category: Gastroenterology Source Type: research

Does preoperative neoadjuvant chemotherapy impact short-term surgical outcomes in patients with locally advanced colon cancer?
AbstractBackgroundPreoperative neoadjuvant chemotherapy (NAC) for colon cancer in advanced stages is associated with improved outcomes and tumor regression. The aim of our study was to identify outcomes in patients with colon cancer who received preoperative NAC.MethodsA 4-year analysis of the American College of Surgeons-National Surgical Quality Improvement Program (ACS-NSQIP) was performed. We included patients with locally advanced colon cancer (non-metastatic T3, T4 with or without nodal involvement) who underwent colon cancer resection. Patients were stratified into two groups (NAC and No-NAC). Our outcome measures w...
Source: International Journal of Colorectal Disease - May 8, 2021 Category: Gastroenterology Source Type: research

Profile of patients with inflammatory bowel disease in conjunction with unmet needs and decision-making for choosing a new biologic therapy: a baseline analysis of the VEDO IBD -Study
ConclusionThis study highlights the existence of unmet medical needs of patients with CD or UC, for whom a new biological therapy is planned as part of the VEDOIBD-Study, which considerably impacts their HRQoL. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - May 8, 2021 Category: Gastroenterology Source Type: research

Correction to: Surgical management of complex ileocolonic Crohn ’s disease: a survey of IBD colorectal surgeons to assess variability in operative strategy
A correction to this paper has been published:https://doi.org/10.1007/s00384-021-03942-6 (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - May 7, 2021 Category: Gastroenterology Source Type: research

Neoadjuvant chemotherapy in locally advanced colon cancer: a systematic review and meta-analysis
ConclusionsOur systematic review and meta-analysis show that NAC is safe with an acceptable side effect profile in the management of LACC. The current data supports an oncological benefit for tumour downstaging and increased in R0 resection rate. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - May 4, 2021 Category: Gastroenterology Source Type: research

Diverticular disease is associated with an increased incidence rate of depression and anxiety disorders
AbstractBackgroundDiverticular disease represents a gastrointestinal disorder of high prevalence in developed countries that often leads to psychological distress. Here, we aimed at evaluating a potential association between diverticular disease and depression or anxiety disorders in outpatients in Germany.MethodsUsing the Disease Analyzer database featuring data of over 8 million patients treated in German general practices, we identified 61.556 patients with diverticular disease (ICD-10: K57) who were 1:1 matched by age, sex, index year, and the Charlson Comorbidity Index to 61.556 patients without diverticular disease. ...
Source: International Journal of Colorectal Disease - May 3, 2021 Category: Gastroenterology Source Type: research

Therapeutic effects and limitations of chemoradiotherapy in advanced lower rectal cancer focusing on T4b
ConclusionIn T4b rectal cancer, preoperative CRT demonstrated a limited benefit for local control and survival. In cases of suspected T4b rectal tumors, additional therapies such as induction chemotherapy to conventional CRT may contribute to better outcomes. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - May 3, 2021 Category: Gastroenterology Source Type: research

Increasing colorectal cancer in the young population and tailoring of the colorectal cancer screening recommendations in subpopulation: a retrospective single-center study
ConclusionsCRC is increasing in the younger population, and Hispanics are diagnosed with CRC usually at a younger age. Early screening in young populations with average risk and even earlier screening in high-risk populations like Hispanics is warranted for timely recognition for prevention, early management, and reduction of mortality. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - May 2, 2021 Category: Gastroenterology Source Type: research

CIP2A regulates MYC translation (via its 5 ′UTR) in colorectal cancer
ConclusionsThus, instead of targeting MYC protein stability as reported for other tissue types before, CIP2A specifically regulates MYC mRNA translation in CRC but has only slight effects on global mRNA translation. In conclusion, we propose as novel mechanism that CIP2A regulates MYC on a translational level rather than affecting MYC protein stability in CRC. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - April 8, 2021 Category: Gastroenterology Source Type: research

Endoscopic full thickness resection vs. transanal endoscopic microsurgery for local treatment of rectal neuroendocrine tumors  - a retrospective analysis
ConclusioneFTR is a convincing method for local treatment of small rectal NETs combining high safety and efficacy with short interventional time. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - April 8, 2021 Category: Gastroenterology Source Type: research

3D pelvimetry and biometric measurements: a surgical perspective for colorectal resections
AbstractPurposeMale sex, high BMI, narrow pelvis, and bulky mesorectum were acknowledged as clinical variables correlated with a difficult pelvic dissection in colorectal surgery. This paper aimed at comparing pelvic biometric measurements in female and male patients and at providing a perspective on how pelvimetry segmentation may help in visualizing mesorectal distribution.MethodsA 3D software was used for segmentation of DICOM data of consecutive patients aged 60  years, who underwent elective abdominal CT scan. The following measurements were estimated: pelvic inlet, outlet, and depth; pubic tubercle height; dista...
Source: International Journal of Colorectal Disease - April 8, 2021 Category: Gastroenterology Source Type: research

New modality for the quantitative evaluation of tissue elasticity using a forward-viewing radial-array echoendoscope for colorectal neoplasms
AbstractPurposeSound speed correction (SSC) is a non-invasive modality that quantifies the hardness of neoplasms. The aim of our study was to evaluate the usefulness of SSC for the diagnostic accuracy of colorectal neoplasms and to differentiate the depth of invasion.MethodsForty colorectal neoplasms, contributed by 40 patients, were included in the analysis. The primary outcome was the diagnostic ability of SSC for the depth of invasion of colorectal neoplasms, with the secondary endpoint being the clinical efficacy of SSC to distinguish between a neoplasm and normal mucosa.ResultsThe median sound speeds for colorectal ne...
Source: International Journal of Colorectal Disease - April 8, 2021 Category: Gastroenterology Source Type: research