Management of colorectal anastomotic leakage using endoscopic negative pressure therapy with or without protective ostomy: a retrospective study
AbstractPurposeManagement of colorectal anastomotic leakage (AL) is patient-oriented and requires an interdisciplinary approach. We analyzed the management of AL according to its severity and presence of ostomy and proposed a therapy algorithm.MethodsWe identified all patients who underwent colorectal surgery and developed an AL in our clinic between 2012 and 2017. The management of AL was retrospectively analyzed according to the severity grade: asymptomatic (A), requesting interventional or antibiotic therapy (B), undergoing re-operation (C). The groups were compared according to the leakage characteristics, presence of ...
Source: International Journal of Colorectal Disease - September 9, 2021 Category: Gastroenterology Source Type: research

Acute appendicitis in elderly during Covid-19 pandemic
ConclusionOur data highlighted a partial delay in diagnosis in the elderly group, and an increase in complicated appendicitis also demonstrated by the need for conversion to laparotomy. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - September 9, 2021 Category: Gastroenterology Source Type: research

Colorectal neoplasms in melanosis coli: a survey in Japan and a worldwide meta-analysis
AbstractPurposeThe association between melanosis coli (MC) and colorectal neoplasms remains unclear. Thus, we primarily aimed to clarify the epidemiology of MC in the Japanese population, identify the relationship between the use of anthranoids and MC, and determine the prevalence of detected intestinal lesions in patients with MC. We subsequently conducted a meta-analysis of published data, including our results, to summarize the influence of MC on the prevalence of colonic neoplasms.MethodsWe conducted a retrospective survey in Japan to investigate the effects of MC on intestinal disorders. The prevalence of colorectal n...
Source: International Journal of Colorectal Disease - September 9, 2021 Category: Gastroenterology Source Type: research

An analysis about the function of a new artificial intelligence, CAD EYE with the lesion recognition and diagnosis for colorectal polyps in clinical practice
ConclusionsCAD EYE was a helpful tool for CADe and CADx in clinical practice. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - September 9, 2021 Category: Gastroenterology Source Type: research

Pilonidal sinus disease on the rise: a one-third incidence increase in inpatients in 13 years with substantial regional variation in Germany
ConclusionRates of inpatient episodes of pilonidal sinus disease in Germany rose across almost all age groups and both sexes with relevant regional variation. The underlying causative factors are unknown. Thus, patient-centred research is necessary to explore them. This should also take cases into account that are solely treated office-based in order to obtain a full-spectrum view of pilonidal sinus disease incidence rates. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - September 9, 2021 Category: Gastroenterology Source Type: research

Proposition of a simple binary grading of estimated blood loss during colon surgery
AbstractPurposeIntraoperative estimated blood loss (EBL) is often reported in nearly all surgical papers; however, there is no consensus regarding its measurement. The aim of this study was to determine whether EBL (ml) is as reliable and reproducible in predicting complications as a simple binary grading of EBL.MethodsAll consecutive patients undergoing colectomies between January 2015 and December 2018 were included. EBL was assessed prospectively by the surgeon and anaesthesiologist in ml and with a binary scale: bleeding “as usual” versus “more than usual” by the surgeon. Differences between pre...
Source: International Journal of Colorectal Disease - September 9, 2021 Category: Gastroenterology Source Type: research

Reversal of end-ileostomy in patients with Crohn ’s disease
ConclusionClosure of end-ileostomy could be complicated by some serious morbidity. These risks should be taken into consideration weighing carefully between the one- and two-stage ileocolic resection in Crohn ’s disease patients. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - September 9, 2021 Category: Gastroenterology Source Type: research

Apparent diffusion coefficient cannot discriminate metastatic and non-metastatic lymph nodes in rectal cancer: a meta-analysis
ConclusionNo reliable ADC threshold can be recommended for distinguishing of metastatic and non-metastatic LN in rectal cancer. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - September 9, 2021 Category: Gastroenterology Source Type: research

Metabolic syndrome and the risk of colorectal cancer: a systematic review and meta-analysis
AbstractPurposeObservational studies have reported an association between metabolic syndrome (MetS) and colorectal cancer risk with inconsistent risk estimates. We conducted this meta-analysis to evaluate the risk of colorectal cancer in individuals with MetS.MethodsPubMed, Embase, and Web of Science were searched for related studies from database inception to 21 January 2021. Risk estimates for colorectal cancer were extracted from individual articles and pooled using a fixed-effect or random-effect model according to the heterogeneity.ResultsMetS was significantly associated with a higher risk of colorectal cancer in bot...
Source: International Journal of Colorectal Disease - September 9, 2021 Category: Gastroenterology Source Type: research

Stage II colon cancer staging using the number of retrieved lymph nodes may be superior to current TNM staging for prognosis stratification: the Japanese study group for postoperative follow-up of colorectal cancer
ConclusionStage II colon cancer staging using the number of retrieved lymph nodes may be superior to current TNM staging for prognosis stratification. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - September 9, 2021 Category: Gastroenterology Source Type: research

The impact of gender and HPV status on anal squamous cell carcinoma survival
AbstractBackgroundAnal cancer is a rare entity and the effect of gender and HPV status on survival is controversial. We aimed to evaluate the difference in overall survival (OS) according to gender and analyzed the effect of HPV status on OS.Patients and methodsThe National Cancer Database (NCDB) was queried for patients with anal squamous cell carcinoma between 2004 and 2016. We evaluated the OS based on gender and HPV status using Kaplan-Meier estimates and we used multivariate Cox regression analyses to evaluate factors associated with overall survival.ResultsA total of 6133 patients with known HPV status were included ...
Source: International Journal of Colorectal Disease - September 9, 2021 Category: Gastroenterology Source Type: research

Risk factors for upper and lower type prolonged postoperative ileus following surgery for Crohn ’s disease
ConclusionThis study identified different risk factors for upper and lower PPOI after ileocecal resection in patients with CD. A differentiated upper/lower type approach should be considered in future research and clinical practice. High-risk patients for each type of PPOI should be closely monitored, and modifiable risk factors, such as preoperative anemia and opioids, should be avoided if possible. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - September 9, 2021 Category: Gastroenterology Source Type: research

Surgery for anal fistulae: state of the art
ConclusionPostoperative incontinence in transsphincteric AF may be minimized by both costless and costly sphincter-saving procedures, the latter carrying higher recurrence rate. The success of surgery may be increased by a different lifestyle. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - September 9, 2021 Category: Gastroenterology Source Type: research

Laparoscopic appendectomy versus antibiotic treatment for acute appendicitis —a systematic review
ConclusionsTo date, there are no studies comparing antibiotic treatment to laparoscopic appendectomy for patients with acute uncomplicated appendicitis, thus emphasizing the lack of evidence and need for further investigation. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - September 9, 2021 Category: Gastroenterology Source Type: research

Surgery, selection or biology in lung metastasectomy for colorectal lung metastasectomy? PulMiCC may not provide all the answers but it does narrow down the question
(Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - September 9, 2021 Category: Gastroenterology Source Type: research

Management, treatment and prognostic significance of lateral lymph node metastases in rectal cancer —a regional cohort study
ConclusionLateral lymph node metastases present a challenging clinical situation. The present study shows that combination of neoadjuvant therapy and selective LLND is an applicable strategy in cases of MRI-positive LLN. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - September 6, 2021 Category: Gastroenterology Source Type: research

Risk factors for developing anorectal dysfunction after anterior resection
AbstractBackgroundAnterior resection (AR) may result in defecatory dysfunction and the cause is multifactorial. The aim was to explore if dysfunction could be related to the part of the colon used for anastomosis (sigmoid or descending) and to identify other possible risk factors for bowel dysfunction after AR.MethodsThis is a retrospective study based on prospectively registered data from a regional registry at the surgical department in V ästmanland 1996–2019. Bowel function was registered at 1 year after AR or after stoma reversal. In total, 470 stage I–III rectal cancer patients had AR whereof 412...
Source: International Journal of Colorectal Disease - September 2, 2021 Category: Gastroenterology Source Type: research

Association between vedolizumab and postoperative complications in IBD: a systematic review and meta-analysis
AbstractBackgroundThe effect of preoperative vedolizumab (VDZ) therapy on postoperative complications in inflammatory bowel disease (IBD) patients is still controversial. This meta-analysis aims to review postoperative complications of IBD patients who preoperatively received VDZ.MethodsA meta-analysis of the available literature was performed. Studies of IBD patients who received VDZ and non-VDZ therapy (including anti-TNF- α agents, non-biological therapy, other biological agents, ustekinumab, and placebo) before surgery were included. Primary outcomes included overall complications, infectious complications, and n...
Source: International Journal of Colorectal Disease - September 1, 2021 Category: Gastroenterology Source Type: research

Right-side colectomy with complete mesocolic excision vs conventional right-side colectomy in the treatment of colon cancer: a systematic review and meta-analysis
ConclusionComplete mesocolic excision of the right-side colectomy improves oncological outcomes without increasing mortality and morbidity rates compared to standard right-side hemicolectomy. CME should therefore be routinely performed in the treatment of right-side colon cancer. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - August 30, 2021 Category: Gastroenterology Source Type: research

Fistula Laser Closure (FiLaC ™) for fistula-in-ano—yet another technique with 50% healing rates?
ConclusionFistula closure with FiLaC ™ had success rates comparable to that of other sphincter-sparing techniques. The technique seems safe with respect to adverse events and risk of incontinence. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - August 30, 2021 Category: Gastroenterology Source Type: research

Risk and prognostic nomograms for colorectal neuroendocrine neoplasm with liver metastasis: a population-based study
ConclusionsThis research identified the risk and prognostic factors in colorectal NENs patients with LM. The nomograms constructed by this study can be convenient tools for facilitating clinical decision-making. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - August 30, 2021 Category: Gastroenterology Source Type: research

Early postoperative pain as a marker of anastomotic leakage in colorectal cancer surgery
ConclusionIn this population-based retrospective study on prospectively collected data, increased pain in the post-anaesthesia care unit is an independent marker of anastomotic leakage, possibly indicating a need for further diagnostic measures. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - August 30, 2021 Category: Gastroenterology Source Type: research

Prevalence and risk factors of sexual dysfunction in patients with inflammatory bowel disease: systematic review and meta-analysis
AbstractPurposeSexual dysfunction (SD) is increasingly identified in patients with inflammatory bowel disease (IBD), but there are few systematic reviews and meta-analyses of the studies of SD in IBD patients. The purpose of the study is to further quantify the association between IBD and SD.MethodsMEDLINE (OVID), EMBASE (OVID), and the Cochrane Library (OVID) were searched (until August 2020) to identify observational studies that reported the prevalence and risk factors of SD in IBD patients. Pooled prevalence, odds ratios (ORs), and 95% confidence intervals (95% CIs) were calculated.ResultsOf the 945 citations evaluated...
Source: International Journal of Colorectal Disease - August 30, 2021 Category: Gastroenterology Source Type: research

Sacral nerve stimulation in patients with ileal pouch-anal anastomosis
ConclusionSNS implantation improves symptoms in over two-thirds of patients suffering from high stool frequency or fecal incontinence after proctocolectomy with IPAA. Awareness of the beneficial effects of SNS should be increased in physicians involved in the management of these patients. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - August 30, 2021 Category: Gastroenterology Source Type: research

An update on surgical treatment of hemorrhoidal disease: a systematic review and meta-analysis
ConclusionThere are multiple favorable techniques without a clear “gold standard” based on current literature. Open discussion should be had between patients and physicians to guide individualized care. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - August 30, 2021 Category: Gastroenterology Source Type: research

Neurogenic appendicopathy: an underestimated disease —systematic review of the literature
ConclusionsNA is a poorly known disease, which may clinically appear as AA but is often related to recurrent and longer lasting abdominal pain. Patients with NA may suffer for years before diagnosis. In cases of typical symptoms, appendectomy should be performed even in cases of macroscopically and radiologically normal-appearing appendices with normal laboratory results. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - August 30, 2021 Category: Gastroenterology Source Type: research

Prediction of the postoperative 90-day mortality after acute colorectal cancer surgery: development and temporal validation of the ACORCA model
ConclusionWe developed prediction model for 90-day mortality after acute colorectal cancer surgery that may be a promising tool for surgeons to identify patients at risk of postoperative mortality. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - August 30, 2021 Category: Gastroenterology Source Type: research

Mechanical bowel preparation combined with oral antibiotics in colorectal cancer surgery: a nationwide population-based study
This study aimed to reveal the effect of oral antibiotics combined with mechanical bowel preparation in colorectal surgery.MethodsThis study was a nationwide population-based retrospective study. Data between January 1, 2016, and December 31, 2018, from the Korean National Health Insurance Service database were analyzed. Patients who underwent elective colorectal cancer surgery were included.ResultsA total of 20,740 patients were finally included, comprising 14,554 (70.2%) who underwent mechanical bowel preparation alone and 6186 (29.8%) who underwent mechanical bowel preparation with oral antibiotics. The mechanical bowel...
Source: International Journal of Colorectal Disease - August 30, 2021 Category: Gastroenterology Source Type: research

State-of-the-art colorectal disease: postoperative ileus
ConclusionThe results of different studies are often contradictory, as a concise definition of POI and reliable surrogate endpoints are still absent. These will be needed to advance POI research and provide clinicians with consistent data to improve the treatment strategies. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - August 30, 2021 Category: Gastroenterology Source Type: research

Mechanical plus oral bowel preparation with paromomycin and metronidazole reduces infectious complications in elective colorectal surgery: a matched case-control study
ConclusionsOral paromomycin and metronidazole with intravenous ertapenem effectively reduce infectious complications in elective colorectal surgery.Trial registrationThe study was registered atClinicaltrials.gov (NCT03759886) December 17, 2018 (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - August 30, 2021 Category: Gastroenterology Source Type: research

Prophylactic mesh placement at index permanent end colostomy creation to prevent parastomal hernia —an updated meta-analysis
ConclusionPMI may reduce the rate of subsequent PSH. However, further studies are required to confirm these findings and to establish the optimal mesh position and shape before definite recommendations can be made. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - August 30, 2021 Category: Gastroenterology Source Type: research

Defining benchmarks for robotic-assisted low anterior rectum resection in low-morbid patients: a multicenter analysis
AbstractPurposeTo define the best possible outcomes for robotic-assisted low anterior rectum resection (RLAR) using total mesorectal excision (TME) in low-morbid patients, performed by expert robotic surgeons in German robotic centers. The benchmark values were derived from these results.MethodsThe data was retrospectively collected from five German expert centers. After patient exclusion (prior surgery, extended surgery, no prior anastomosis, hand-sewn anastomosis), the benchmark cohort was defined (n  = 226). The median with interquartile range was first calculated for the individual centers. The 75th perce...
Source: International Journal of Colorectal Disease - August 30, 2021 Category: Gastroenterology Source Type: research

Second redo surgery after two consecutive failures of a colorectal or coloanal anastomosis: is it reasonable?
ConclusionA 63% rate of success of second redo surgery was observed after two failed CRA or CAA. Although a demanding procedure, it can be proposed to carefully selected and motivated patients. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - August 30, 2021 Category: Gastroenterology Source Type: research

Safety of biologics in inflammatory bowel disease patients with COVID-19
ConclusionsOur findings advocate for the continued biologic therapy in IBD patients during the COVID-19 pandemic. Nevertheless, the incidence, severity, and outcomes related to COVID-19 in IBD patients ’ needs to be reassessed as data continues to emerge. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - August 30, 2021 Category: Gastroenterology Source Type: research

Correction to: Mechanical plus oral bowel preparation with paromomycin and metronidazole reduces infectious complications in elective colorectal surgery: a matched case –control study
A correction to this paper has been published:https://doi.org/10.1007/s00384-021-03980-0 (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - August 30, 2021 Category: Gastroenterology Source Type: research

Correction to: Prevalence and risk factors of sexual dysfunction in patients with inflammatory bowel disease: systematic review and meta ‑analysis
(Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - August 30, 2021 Category: Gastroenterology Source Type: research

Correction to: False-positive fecal immunochemical test results in colorectal cancer screening and gastrointestinal drug use
A correction to this paper has been published:https://doi.org/10.1007/s00384-021-03947-1 (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - August 30, 2021 Category: Gastroenterology Source Type: research

Correction to: CIP2A regulates MYC translation (via its 5 ′UTR) in colorectal cancer
A correction to this paper has been published: https://doi.org/10.1007/s00384-021-03960-4The original version of this article was revised due to a retrospective Open Access order. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - August 30, 2021 Category: Gastroenterology Source Type: research

Fistula Laser Closure (FiLaC ™) for fistula-in-ano—yet another technique with 50% healing rates?
ConclusionFistula closure with FiLaC ™ had success rates comparable to that of other sphincter-sparing techniques. The technique seems safe with respect to adverse events and risk of incontinence. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - August 9, 2021 Category: Gastroenterology Source Type: research

Early postoperative pain as a marker of anastomotic leakage in colorectal cancer surgery
ConclusionIn this population-based retrospective study on prospectively collected data, increased pain in the post-anaesthesia care unit is an independent marker of anastomotic leakage, possibly indicating a need for further diagnostic measures. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - August 9, 2021 Category: Gastroenterology Source Type: research

Prevalence and risk factors of sexual dysfunction in patients with inflammatory bowel disease: systematic review and meta-analysis
AbstractPurposeSexual dysfunction (SD) is increasingly identified in patients with inflammatory bowel disease (IBD), but there are few systematic reviews and meta-analyses of the studies of SD in IBD patients. The purpose of the study is to further quantify the association between IBD and SD.MethodsMEDLINE (OVID), EMBASE (OVID), and the Cochrane Library (OVID) were searched (until August 2020) to identify observational studies that reported the prevalence and risk factors of SD in IBD patients. Pooled prevalence, odds ratios (ORs), and 95% confidence intervals (95% CIs) were calculated.ResultsOf the 945 citations evaluated...
Source: International Journal of Colorectal Disease - August 9, 2021 Category: Gastroenterology Source Type: research

Sacral nerve stimulation in patients with ileal pouch-anal anastomosis
ConclusionSNS implantation improves symptoms in over two-thirds of patients suffering from high stool frequency or fecal incontinence after proctocolectomy with IPAA. Awareness of the beneficial effects of SNS should be increased in physicians involved in the management of these patients. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - August 9, 2021 Category: Gastroenterology Source Type: research

Neurogenic appendicopathy: an underestimated disease —systematic review of the literature
ConclusionsNA is a poorly known disease, which may clinically appear as AA but is often related to recurrent and longer lasting abdominal pain. Patients with NA may suffer for years before diagnosis. In cases of typical symptoms, appendectomy should be performed even in cases of macroscopically and radiologically normal-appearing appendices with normal laboratory results. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - August 9, 2021 Category: Gastroenterology Source Type: research

Mechanical plus oral bowel preparation with paromomycin and metronidazole reduces infectious complications in elective colorectal surgery: a matched case-control study
ConclusionsOral paromomycin and metronidazole with intravenous ertapenem effectively reduce infectious complications in elective colorectal surgery.Trial registrationThe study was registered atClinicaltrials.gov (NCT03759886) December 17, 2018 (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - August 9, 2021 Category: Gastroenterology Source Type: research

Prophylactic mesh placement at index permanent end colostomy creation to prevent parastomal hernia —an updated meta-analysis
ConclusionPMI may reduce the rate of subsequent PSH. However, further studies are required to confirm these findings and to establish the optimal mesh position and shape before definite recommendations can be made. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - August 9, 2021 Category: Gastroenterology Source Type: research

Second redo surgery after two consecutive failures of a colorectal or coloanal anastomosis: is it reasonable?
ConclusionA 63% rate of success of second redo surgery was observed after two failed CRA or CAA. Although a demanding procedure, it can be proposed to carefully selected and motivated patients. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - August 9, 2021 Category: Gastroenterology Source Type: research

Safety of biologics in inflammatory bowel disease patients with COVID-19
ConclusionsOur findings advocate for the continued biologic therapy in IBD patients during the COVID-19 pandemic. Nevertheless, the incidence, severity, and outcomes related to COVID-19 in IBD patients ’ needs to be reassessed as data continues to emerge. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - August 9, 2021 Category: Gastroenterology Source Type: research

Correction to: Mechanical plus oral bowel preparation with paromomycin and metronidazole reduces infectious complications in elective colorectal surgery: a matched case –control study
A correction to this paper has been published:https://doi.org/10.1007/s00384-021-03980-0 (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - August 9, 2021 Category: Gastroenterology Source Type: research

Correction to: Prevalence and risk factors of sexual dysfunction in patients with inflammatory bowel disease: systematic review and meta ‑analysis
(Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - August 9, 2021 Category: Gastroenterology Source Type: research