Nomograms for morbidity and mortality after oncologic colon resection in the enhanced recovery era: results from a multicentric prospective national study
ConclusionsRisk factors for morbidity and mortality after CR for cancer were identified and two easy predictive tools were developed. Both of them could provide important information for preoperative consultation and surgical planning in the time of enhance recovery. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - November 7, 2020 Category: Gastroenterology Source Type: research

Anorectal angle at rest predicting successful sacral nerve stimulation in idiopathic fecal incontinence —a cohort analysis
ConclusionsAnorectal angle at rest in preoperative defecography might present a predictor of outcome after sacral nerve stimulation in patients with idiopathic fecal incontinence. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - November 7, 2020 Category: Gastroenterology Source Type: research

Determining whether postoperative chemoradiotherapy is required in patients with pathologic T3N0 rectal cancer with negative resection margin
ConclusionPostoperative CCRT significantly decreased LR in patients with pT3N0 rectal cancer with a negative resection margin but having a distance from the anal verge ≤ 5 cm or DRM ≤ 2 cm. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - November 7, 2020 Category: Gastroenterology Source Type: research

Surgical resection improves overall survival of patients with small bowel leiomyosarcoma
ConclusionSB LMS is a rare disease entity, with treatment centering on complete surgical resection. Our results demonstrate that overall survival is higher than previously thought. Timely diagnosis to allow for complete surgical resection is key, and investigation into the possible role of chemotherapy or radiation therapy is needed. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - November 7, 2020 Category: Gastroenterology Source Type: research

Endoscopic management versus transanal surgery for early primary or early locally recurrent rectal neoplasms —a systematic review and meta-analysis
AbstractBackgroundBoth endoscopic techniques and transanal surgery are viable options that allow organ preservation for early rectal neoplasms. Whilst endoscopic approaches are less invasive and carry less morbidity, it is unclear whether they are as oncologically effective.AimTo compare endoscopic techniques with transanal surgery in the management of early rectal neoplasms.MethodsA systematic literature search was performed for randomised and observational studies comparing these techniques. The pre-specified main outcomes measured were en bloc and R0 resection rates and recurrence. Pair-wise meta-analysis was performed....
Source: International Journal of Colorectal Disease - November 7, 2020 Category: Gastroenterology Source Type: research

Unexplained systemic inflammatory response following ileostomy closure after ileal pouch-anal anastomosis: a deeper dive into a rare entity
AbstractAimThe purpose of this study is to shed light on a rare complication following ileostomy closure after 3-stage IPAA for further study and discussion.MethodsOur department IPAA database was queried for all patients who underwent 3-stage IPAA creation from 2011 through 2018. Data was reviewed and analyzed using the SPSS application. Chi-square test and Fisher ’s exact test were used for categorical variables.t test or ANOVA was used for continuous variables. Significance was set atp
Source: International Journal of Colorectal Disease - November 7, 2020 Category: Gastroenterology Source Type: research

Prognostic relevance of neuroendocrine differentiation in colorectal cancer: a population-based, propensity score matching study
AbstractPurposeNeuroendocrine differentiation (NED) may serve as a prognostic factor in colorectal cancer; however, the prognostic relevance of NED remains controversial. The aim of the present study was to determine whether NED influenced the survival of patients in colorectal cancer while exploring its potential interactions with other clinicopathological features.MethodsPatients with primary stage I to IV colorectal adenocarcinoma ranging between 2010 and 2015 were identified using the Surveillance, Epidemiology, and End Results database. The Kaplan-Meier technique, Cox proportional hazards model, propensity score match...
Source: International Journal of Colorectal Disease - November 7, 2020 Category: Gastroenterology Source Type: research

Risk factors of chemotherapy-induced nausea and vomiting in patients with metastatic colorectal cancer: a prospective cohort study (YCOG1301)
AbstractPurposeAlthough the effectiveness of antiemetic therapy for colorectal cancer chemotherapy has improved with further drug development, some patients still suffer from chemotherapy-induced nausea and vomiting (CINV) even with only 5-hydroxytryptamine-3 receptor antagonist and dexamethasone. The present study investigated the risk factors of CINV in patients who received chemotherapy for colorectal cancer and clarified which patients need additional neurokinin 1 receptor antagonist.MethodsPatients with colorectal cancer receiving moderate-emetic-risk chemotherapy (MEC) were enrolled in this prospective single-arm stu...
Source: International Journal of Colorectal Disease - November 7, 2020 Category: Gastroenterology Source Type: research

What is the appropriate cut-off value of CRP to predict endoscopic remission in patients with ulcerative colitis in clinical remission?
AbstractPurposeNoninvasive markers for predicting endoscopic remission (ER) in patients with ulcerative colitis (UC) who are in clinical remission (CR) are important for the determination of appropriate treatment modality. C-reactive protein (CRP) is a surrogate marker for assessing disease activity, albeit with a low sensitivity and specificity when the cut-off value is 0.3 or 0.5 mg/dL, which is usually considered normal. The CRP test has been improved, and even fine values within the normal range can be measured. The aim of this study was to determine the appropriate cut-off value of CRP below 0.3 mg/dL for the predicti...
Source: International Journal of Colorectal Disease - November 7, 2020 Category: Gastroenterology Source Type: research

Proton pump inhibitors and the risk of colorectal cancer: a systematic review and meta-analysis of observational studies
ConclusionsAlthough the present meta-analysis suggests a weak association between long-term use (> 5 years) of PPIs and CRC, there is not enough statistical power to refute or confirm an association between the use of PPIs and CRC. More high-quality prospective cohort studies are needed to assess this correlation. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - November 7, 2020 Category: Gastroenterology Source Type: research

HBV infection may reduce the risk of metachronous liver metastasis in postoperative pathological stage 2 colorectal cancer
ConclusionHBV infection may reduce the risk of metachronous liver metastasis in stage 2 colorectal cancer. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - November 7, 2020 Category: Gastroenterology Source Type: research

Haemorrhoidectomy under local anaesthesia versus spinal anaesthesia: a systematic review and meta-analysis
ConclusionCompared with SA, LA may be associated with significantly lower post-operative pain, need for rescue analgesia, urinary retention, and headache making it an attractive choice of anaesthesia in day-case surgery for those who are not either fit for GA or refuse such anaesthetic modality. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - November 7, 2020 Category: Gastroenterology Source Type: research

Prognostic significance of lymph node yield in patients with synchronous colorectal carcinomas
ConclusionsRetrieval of fewer than 15 LNs at the first time of SCC diagnosis indicates worse SCC prognosis. Because factors such as manner of surgical examination influence SCC prognosis, specimens should be preserved for at least 6 months to enable reevaluation should there be a need.Irb: IRB approval is not required because the SEER data are freely accessible. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - November 7, 2020 Category: Gastroenterology Source Type: research

A prospective, single-arm, multicenter trial of neoadjuvant chemotherapy with mFOLFOX6 plus panitumumab without radiotherapy for locally advanced rectal cancer
AbstractPurposeThe present study evaluated the safety and efficacy of neoadjuvant chemotherapy with modified 5-fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) plus panitumumab in clinical stage III rectal cancer with KRAS wild-type.MethodsWe conducted a prospective multicenter phase II trial. KRAS wild-type clinical stage III rectal cancer patients were enrolled. Patients received 6 cycles of mFOLFOX6 with 6  mg/kg panitumumab as neoadjuvant chemotherapy. The primary outcome was the response rate (RR) defined by RECIST. Lateral lymph node dissection (LLDN) was performed when patients had a locally advanced tumor
Source: International Journal of Colorectal Disease - November 7, 2020 Category: Gastroenterology Source Type: research

Clinical impact of non-predominant histopathological subtypes on the long-term prognosis of colorectal cancer patients in Japan
AbstractPurposeWe performed a retrospective study to clarify the long-term prognosis of patients with histopathological high-grade colorectal cancer (CRC).MethodsWe reviewed data from 24 institutions for 18,360 patients with pStage I to III CRC who had undergone curative surgery between 2004 and 2012. The patients were classified into seven groups according to the proportion of the histopathological component: classical adenocarcinoma (CAC) group, M-l and M-h groups (
Source: International Journal of Colorectal Disease - November 7, 2020 Category: Gastroenterology Source Type: research

Rate of anastomotic leak following right hemicolectomy by general surgical trainees
ConclusionRH is a common operative procedure in general surgical training. Data from this study may assist with the structuring of surgical training programmes, aimed at maximising both patient safety and trainee professional development and education. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - November 7, 2020 Category: Gastroenterology Source Type: research

Dysplasia detection is similar between chromoendoscopy and high-definition white-light colonoscopy in inflammatory bowel disease patients: a US-matched case-control study
AbstractIntroductionInflammatory bowel disease (IBD) patients are at greater risk of developing colorectal cancer (CRC). Detection of precursor dysplasia is important for cancer prevention. Recent guidelines recommend dye chromoendoscopy (DCE) as the preferred method for dysplasia detection. Universal adoption of DCE is time-consuming and may limit endoscopy access. The benefit of universal application of the guidelines is unclear. We compared high-definition white-light colonoscopy (HD-WLC) with DCE for dysplasia detection in IBD patients.MethodsWe conducted a retrospective case-control study of adult IBD patients undergo...
Source: International Journal of Colorectal Disease - November 7, 2020 Category: Gastroenterology Source Type: research

Ileostomy reversal after subtotal colectomy in Crohn ’s disease: a single institutional experience at a high-volume center
ConclusionIleostomy reversal after STC in Crohn ’s disease is uncommon. Certain treatment regimens and diagnostic factors may impact the likelihood of ostomy reversal. Based on the available data, patients with CD whose disease is severe enough to require STC should be counseled that their ostomy will most likely be permanent. However, due to t he low incidence of this procedure for CD, more data is needed. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - November 7, 2020 Category: Gastroenterology Source Type: research

Indocyanine green fluorescent imaging on anastomotic leakage in colectomies: a network meta-analysis and systematic review
ConclusionWith the ability to potentially avert postoperative anastomotic leakage, coupled with its minimal costs and side effects, administration of ICG in colectomies in centers where equipment is available should be encouraged. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - November 7, 2020 Category: Gastroenterology Source Type: research

Evidence-based treatment strategies for acute diverticulitis
ConclusionRisk-adapted treatment strategies and operative decision-making for acute diverticulitis are increasingly based on a combination of patient and disease factors. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - November 6, 2020 Category: Gastroenterology Source Type: research

Clinical significance of immunohistochemical lymphovascular evaluation to determine additional surgery after endoscopic submucosal dissection for colorectal T1 carcinoma
ConclusionsThe JSCCR guidelines have clinical validity, and immunohistochemical lymphatic evaluation findings potentially predict LN metastasis for T1 CRC after ESD. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - November 4, 2020 Category: Gastroenterology Source Type: research

Outcomes of non-metastatic poorly differentiated gastroenteropancreatic neuroendocrine neoplasms treated with surgery: a real-world population-based study
AbstractObjectiveTo assess the outcomes of non-metastatic poorly differentiated gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) treated with radical surgery.MethodsSurveillance, Epidemiology, and End Results (SEER) database (1998 –2015) was accessed, and patients with non-metastatic poorly differentiated/undifferentiated GEP-NENs were reviewed. Multivariable Cox regression analysis was used to evaluate factors affecting overall survival (OS) and cancer-specific survival (CSS). Patients treated with radical surgery were mat ched to those who did not undergo surgery through propensity score matching and Kapl...
Source: International Journal of Colorectal Disease - November 4, 2020 Category: Gastroenterology Source Type: research

Pouch failures following restorative proctocolectomy in ulcerative colitis
ConclusionsEleven percent of RPC patients suffered pouch failure: more men than women. The reasons were multiple. Crohn ’s disease created a risk of failure, but a half of these patients maintained the pouch. Morbidity after pouch excision was moderate, but in most cases slight. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - October 7, 2020 Category: Gastroenterology Source Type: research

Appendicular neoplasms and consequences in patients undergoing surgery for suspected acute appendicitis
DiscussionThe incidence of appendicular neoplasm in patients undergoing an acute appendectomy is very low and clinical risk factors could not be identified. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - October 7, 2020 Category: Gastroenterology Source Type: research

One-year risk of opioid use disorder after index hospitalization for inflammatory bowel disease
ConclusionPatients with IBD were often readmitted for opiate use disorder and sustained significant mortality and hospital costs. Psychiatric comorbidities, gender, and insurance status impacted the odds of readmission and represent targets for intervention. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - October 7, 2020 Category: Gastroenterology Source Type: research

Qualitative faecal immunochemical tests (FITs) for diagnosing colorectal cancer in patients with histories of rectal bleeding in primary care: a cohort study
ConclusionThe diagnostic performance of a qualitative three-sample FIT provided by symptomatic patients in primary care was similar for those with and without a history of rectal bleeding. FITs seem useful for prioritising patients also with rectal bleeding for further investigation. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - October 7, 2020 Category: Gastroenterology Source Type: research

Incidence and risk factors of postoperative ileus after hysterectomy for benign indications
ConclusionPOI is a common complication after hysterectomy. This study identified risk factors of POI specifically for gynecologic patients. Patients exposed to these factors should be monitored closely for the development POI. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - October 7, 2020 Category: Gastroenterology Source Type: research

Metachronous metastasis confined to isolated lymph node after curative treatment of colorectal cancer
ConclusionThis study suggests that multidisciplinary management is a potentially effective treatment strategy for isolated LNM. Since time to LNM, the T-stage, and histological type are prognostic factors, an active follow-up program for colorectal cancer is required. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - October 7, 2020 Category: Gastroenterology Source Type: research

What is the impact of systemic chemotherapy for lateral lymph nodes in patients with locally advanced low rectal cancer?
AbstractPurposeSystemic chemotherapy (SC) before surgery is a potential treatment to improve survival in patients with advanced rectal cancer. However, the impact of SC on lateral lymph nodes (LLNs) remains unclear.MethodsA total of 78 patients with stage II/III low rectal cancer, who received 3-month oxaliplatin-based SC followed by LLN dissection (LLND) in principle, were analysed retrospectively. “Total lateral lymph node metastases (tLLNMs)” was defined as having either pathological LLNMs (pLLNMs) or lateral local recurrences (LLRs). Patients with the maximum short-axis size of LLNs ≥ 7 mm we...
Source: International Journal of Colorectal Disease - October 7, 2020 Category: Gastroenterology Source Type: research

Prognostic implications of advancing nodal stage in anal cancer: evaluating AJCC 8 staging changes through an NCDB analysis
AbstractPurposeIn the AJCC8, nodal staging for squamous cell carcinoma of the anus (SCCA) has been changed to a binary format (N0 or N+), and overall stage groups have been redefined. We evaluated the effect of AJCC8 nodal stage by T stage and hypothesized similar survival regardless of the extent of AJCC7-defined nodal involvement.MethodsThe National Cancer Database (NCDB) was used to identify patients ’ SCCA. Overall survival (OS) for each T stage within the AJCC7 was compared with increasing nodal stage, as well as for the new AJCC8 overall stage groups and subsets.ResultsThere were 6738 patients analyzed. The 5-y...
Source: International Journal of Colorectal Disease - October 7, 2020 Category: Gastroenterology Source Type: research

Efficacy of biosimilar infliximab CT-P13 among inpatients with severe steroid-refractory colitis
ConclusionA significant proportion of patients with severe colitis failing IV steroids responded to induction therapy with CT-P13. Colectomy-free survival rates were similar to previous randomized trials using originator infliximab as induction therapy in severe steroid-refractory colitis. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - October 7, 2020 Category: Gastroenterology Source Type: research

Letter to the editor regarding “Does adding lateral pelvic lymph node dissection to neoadjuvant chemotherapy improve outcomes in low rectal cancer?”
(Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - October 7, 2020 Category: Gastroenterology Source Type: research

Correction to: Long-term results achieved by guideline-based stage-dependent management of anal cancer in a non-HIV population
The authors of the article mentioned above found out errors on the Table 4 concerning the number and survival rates of patients with incomplete radiotherapy. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - October 7, 2020 Category: Gastroenterology Source Type: research

Early versus delayed endoscopic treatment of acute pilonidal abscess: a propensity score-matched analysis
ConclusionsOur results encouraged to perform an immediate endoscopic approach to an acute pilonidal abscess. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - October 2, 2020 Category: Gastroenterology Source Type: research

Management options for chronic anal fissure: a systematic review of randomised controlled trials
ConclusionThis review of the randomized control data demonstrates that healing was significantly higher amongst those treated with sphincterotomy versus more conservative modalities. Topical nitrites had similar outcomes to botulinum toxin injection but were poorly tolerated in comparison to other treatments. The benefit of sphincterotomy was at a cost of increased complications, notably permanent incontinence. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - September 23, 2020 Category: Gastroenterology Source Type: research

Modified two-stage restorative proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis: a systematic review and meta-analysis of observational research
We present a systematic review and meta-analysis comparing postoperative complication rates between modified 2-stage and traditional RPC with ileal pouch anal anastomosis.MethodsRecords were sourced from PubMed/Embase databases. Studies comparing postoperative complications following RPC for ulcerative colitis (UC) were selected according to PRISMA guidelines comparing modified 2-stage (exposure), classic 2-stage, and 3-stage approaches (comparators). The primary outcome measure was safety as measured by postoperative complication rates. We employed random effects meta-analysis.ResultsWe included ten observational studies ...
Source: International Journal of Colorectal Disease - September 23, 2020 Category: Gastroenterology Source Type: research

Different clinicopathological features of non-elderly sigmoid volvulus patients
ConclusionBy decreasing age, male dominance disappears progressively, and it is likely to have an underlying colonic hypomotility in young sigmoid volvulus patients. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - September 23, 2020 Category: Gastroenterology Source Type: research

Clinical outcomes of sigmoid volvulus and risk factors for its recurrence: a multicenter study in Korea
ConclusionAlthough non-operative treatment can be initially attempted, surgery is required for preventing recurrence. Regular surgery should be considered to restore continuity of the bowel. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - September 23, 2020 Category: Gastroenterology Source Type: research

Oxaliplatin versus mitomycin C in HIPEC for peritoneal metastasis from colorectal cancer: a systematic review and meta-analysis of comparative studies
ConclusionOX and MMC could achieve comparable survival in HIPEC for PM from CRC. However, in consideration of the high incidence of major complication in OX group, MMC might be the safer one in clinical routines. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - September 23, 2020 Category: Gastroenterology Source Type: research

Correction to: Different clinicopathological features of non-elderly sigmoid volvulus patients
The presentation of“≤ 60 age group” throughout the article were incorrect. The data should have been presented as“60≤ age group”. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - September 23, 2020 Category: Gastroenterology Source Type: research

Preoperative versus pathological staging of rectal cancer —challenging the indication of neoadjuvant chemoradiotherapy
ConclusionFor patients without neoadjuvant CRT, a tendency to preoperative overstaging was observed. Lymph node size alone did not reliably predict metastasis. According to current guidelines, 21/62 (33.9%) of these patients would have been overtreated by using CRT. On the background of relevant side effects, complications, and the limited benefit of CRT on overall survival, we suggest that primary surgical resection should be recommended more liberally for stages II and III rectal cancer. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - September 20, 2020 Category: Gastroenterology Source Type: research

Submucosal lifting agent ORISE gel causes extensive foreign body granuloma post endoscopic resection
ConclusionThese cases raise the awareness that ORISETM gel stimulates extensive foreign body reaction at the injection site, and the further consequence is still unclear. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - September 20, 2020 Category: Gastroenterology Source Type: research

Letter to the editor regarding “Intra-versus extracorporeal anastomosis in laparoscopic right colectomy: a meta-analysis of 3699 patients”
(Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - September 20, 2020 Category: Gastroenterology Source Type: research

Response to neoadjuvant treatment among rectal cancer patients in a population-based cohort
ConclusionIn this study, patient characteristics were not associated with response to neoadjuvant treatment, and molecular characteristics determined after surgical resection of the tumor were not predictive of pCR or tumor downstaging. Future studies should include molecular biomarkers from biopsy samples before neoadjuvant treatment. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - September 18, 2020 Category: Gastroenterology Source Type: research

Does intraoperative indocyanine green fluorescence angiography decrease the incidence of anastomotic leakage in colorectal surgery? A systematic review and meta-analysis
AbstractBackgroundColorectal anastomoses in patients with colorectal cancer carry a high risk of leakage. Indocyanine green fluorescence angiography (ICG-FA) is a new technique that allows surgeons to assess the blood perfusion of the anastomosis during operation. This meta-analysis aimed to evaluate whether ICG-FA could prevent anastomotic leakage (AL) in colorectal surgery.MethodsFour databases (PubMed, Embase, Web of Science, and Cochrane Library) were searched to identify suitable literatures until March 2020 that compared AL rates between intraoperative use and non-use of ICG-FA in colorectal surgery for cancer. The R...
Source: International Journal of Colorectal Disease - September 17, 2020 Category: Gastroenterology Source Type: research

The effect of a simple phone call intervention on FIT-positive individuals: an exploratory study
ConclusionThe results suggest that a simple, structured telephone call can potentially encourage more FIT-positive individuals to pursue follow-up investigation. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - September 17, 2020 Category: Gastroenterology Source Type: research

Diagnostic methods and drug therapies in patients with ischemic colitis
ConclusionAccurate diagnoses and effective treatmentshave helped reduce the mortality rate and improve prognoses for patientsafflicted with IC, and corresponding drug therapies have been constantlyupdated as new research has emerged. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - September 15, 2020 Category: Gastroenterology Source Type: research

Retrospective risk analysis for acute urinary dysfunction after laparoscopic rectal cancer surgery in patients receiving epidural analgesia
ConclusionOur findings suggest that older age, early removal of urinal catheter before epidural analgesia discontinuation, and large tumor circumference rate are risk factors of acute UD after LALAR for rectal cancer in patients receiving epidural analgesia. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - September 14, 2020 Category: Gastroenterology Source Type: research

Negative pressure therapy for stoma closure sites —a nonrandomised case control study
ConclusionThose who had a PICO dressing required fewer visits to the community nurse and the majority were able to return to work or resume usual activities within 1 to 2 weeks. This pilot study suggests that negative pressure dressings may be a useful aid for stoma closure site wounds. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - September 13, 2020 Category: Gastroenterology Source Type: research

To perform genotyping of dihydropyrimidine dehydrogenase (DPD) before starting treatment with 5-fluorouracil or related medicines: really feasible?
(Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - September 13, 2020 Category: Gastroenterology Source Type: research