Meta-analysis on current status, efficacy, and safety of laparoscopic and robotic ventral mesh rectopexy for rectal prolapse treatment: can robotic surgery become the gold standard?
ConclusionThe result of the current analysis revealed that the robotic-assisted ventral mesh rectopexy is effective and feasible in the treatment of rectal prolapse. However, long-term follow-up and results are needed for the promotion of this approach. There is a long way for robotic-assisted surgery to become a gold standard in rectal surgery. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - March 1, 2021 Category: Gastroenterology Source Type: research

Needle aspiration treatment vs. incision of acute simple perianal abscess: randomized controlled study
ConclusionNeedle aspiration with postoperative antibiotics cannot be recommended as an alternative for surgical incision in the treatment of acute perianal abscess.Trial registration numberClinicalTrials.org with identification number NCT02585141, initial release on 15 October 2015. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - February 20, 2021 Category: Gastroenterology Source Type: research

A meta-analysis of the role of diverting ileostomy after rectal cancer surgery
ConclusionA lower leak rate in the presence of diverting ileostomy is supported by relatively weak evidence. While mitigating the consequences of leakage, diverting ileostomies lead to numerous other complications. High-quality RCTs are needed before routine ileostomy diversions can be recommended after rectal cancer surgery. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - February 20, 2021 Category: Gastroenterology Source Type: research

Lateral pelvic lymphadenectomy for low rectal cancer: a META-analysis of recurrence rates
ConclusionThe addition of LPLND to TME is not associated with a significantly lower risk of LR in patients who undergo surgery for lower rectal cancer. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - February 20, 2021 Category: Gastroenterology Source Type: research

Association of certification, improved quality and better oncological outcomes for rectal cancer in a specialized colorectal unit
ConclusionsCertification as specialized centre and regular audits were associated with an improvement of various quality parameters. The formal certification process has the potential to enhance quality of care for rectal cancer patients. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - February 20, 2021 Category: Gastroenterology Source Type: research

Fecal-oral transmission of SARS-CoV-2: review of laboratory-confirmed virus in gastrointestinal system
ConclusionIn order to control the pandemic, every effort should be made to understand all the possible routes of transmission of the infections, even the less important ones. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - February 20, 2021 Category: Gastroenterology Source Type: research

Surgical resection after endoscopic resection in patients with T1 colorectal cancer: a meta-analysis
This study aimed to compare the effectiveness of ER vs. ER + ASR as a treatment for patients with T1 (stage 1) CRC.MethodsWe performed a systematic search from databases (PubMed, Embase, and Cochrane library) for cohort studies published up to November 2019. The outcomes were overall survival (OS), local recurrence, recurrence, disease-specific survival, recurrence-free survival, and metastasis.ResultsSeven studies were included. There were 1205 patients in the ASR group and 993 patients in the ER group. Compared with ER, ASR was associated with better OS (OR = 0.31, 95% CI: 0.18 –0.53,P
Source: International Journal of Colorectal Disease - February 20, 2021 Category: Gastroenterology Source Type: research

Are colorectal cancer patients at risk for COVID-19 infection during the postoperative period? The Covid-GRECCAR study
ConclusionThe results are reassuring, with only a 1.3% infection rate and no deaths related to COVID-19. We believe that we can operate on colorectal cancer patients without additional mortality from COVID-19, applying all measures aimed at reducing the risk of infection. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - February 20, 2021 Category: Gastroenterology Source Type: research

Real-world patterns of chemotherapy administration and attrition among patients with metastatic colorectal cancer
ConclusionsA considerable proportion of metastatic colorectal cancer patients who received active chemotherapy in this population-based study received only one line of therapy. This highlights the significance of choosing effective treatments in the first-line treatment as the attrition rate is high. Furthermore, the use of all three chemotherapy agents across the course of treatment was associated with better outcomes. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - February 20, 2021 Category: Gastroenterology Source Type: research

A meta-analysis of marsupialisation versus none in the treatment of simple fistula-in-ano
AbstractIntroductionMarsupialisation of post-fistulotomy wounds results in a smaller raw surface area and may improve postoperative outcomes. However, it remains a variable practice. We performed a systematic review and meta-analysis to evaluate the effectiveness of marsupialisation in the treatment of simple fistula-in-ano.Materials and methodsPubMed, EMBASE and Cochrane databases were searched for relevant articles from inception until April 2020. All trials that reported on marsupialisation in anal fistula treatment were included. The primary outcome measure was time to complete healing, while secondary outcomes include...
Source: International Journal of Colorectal Disease - February 20, 2021 Category: Gastroenterology Source Type: research

Endoscopically removed rectal NETs: a nationwide cohort study
ConclusionNo lymph node or distant metastases were seen in endoscopically removed G1 NETs up to 20 mm during the long follow-up of this nationwide study. This adds evidence to the ENET guideline that endoscopic resection of G1 NETs up to 20 mm appears to be safe. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - February 20, 2021 Category: Gastroenterology Source Type: research

Downstaged ypT0-2N0 rectal cancer after neoadjuvant chemoradiation therapy may not need adjuvant chemotherapy: a retrospective cohort study
This study aimed to evaluate the necessity of AC for ypT0-2N0 rectal cancer.MethodsPatients with ypT0-2N0 rectal cancer, who received nCRT and radical surgical resection, were recruited retrospectively at a university hospital. The main outcome was to evaluate the 5-year overall survival (OS) and disease-free survival (DFS) between ypT0-2N0 rectal cancer patients with AC and those without AC. We also identified potential independent prognostic factors associated with poor outcomes.ResultsOne hundred and ten ypT0-2N0 rectal cancer patients (ypT0:n = 6; ypT1:n = 44; ypT2:n = 60) were followed up for a median of 60 months. No...
Source: International Journal of Colorectal Disease - February 20, 2021 Category: Gastroenterology Source Type: research

Feasibility assessment of outpatient colorectal resections at a tertiary referral center
AbstractPurposeEnhanced Recovery After Surgery (ERAS) protocols, particularly when paired with advanced laparoscopy, have reduced recovery time following colorectal procedures. The aim of this study was to determine if length of stay (LOS) could be reduced to an overnight observation stay (
Source: International Journal of Colorectal Disease - February 20, 2021 Category: Gastroenterology Source Type: research

Radiofrequency thermocoagulation of haemorrhoidal bundles, an alternative technique for the management of internal haemorrhoids
AbstractPurposeTo describe our experience of radiofrequency thermocoagulation (RFT), assessing patient symptoms and quality of life (QoL) before and after the intervention.MethodsBetween April 2016 and April 2018, 42 outpatients were operated for internal haemorrhoids using RFT. Haemorrhoids were externalised to the anal margin and treated by using the Rafaelo ® procedure, using the HPR45i probe (F-Care-Systems) under general anaesthesia. Assessment was performed prior to the intervention and during follow-up for prolapse degree using the Goligher scale; bleeding, improvement, and satisfaction using a verbal analogical...
Source: International Journal of Colorectal Disease - February 20, 2021 Category: Gastroenterology Source Type: research

Fluoroscopy and endoscopy –guided transanastomotic rendezvous: a novel technique for recanalization of a completely obstructed colorectal anastomosis
ConclusionFluoroscopy-endoscopy-guided recanalization is an effective and safe treatment option for complete colorectal anastomotic stricture. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - February 20, 2021 Category: Gastroenterology Source Type: research

Appendectomy in childhood —did it save my sibling from getting ulcerative colitis?
(Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - February 20, 2021 Category: Gastroenterology Source Type: research

Correction to: Appendectomy versus conservative treatment with antibiotics for patients with uncomplicated acute appendicitis: a propensity score –matched analysis of patient-centered outcomes (the ACTUAA prospective multicenter trial)
A Correction to this paper has been published:https://doi.org/10.1007/s00384-021-03862-5 (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - February 20, 2021 Category: Gastroenterology Source Type: research

Oral antibiotic bowel decontamination in open and laparoscopic sigmoid resections for diverticular disease
ConclusionOral antibiotic decontamination appears to be safe and effective with low rates of AL and infectious complications in surgery for diverticular disease. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - February 19, 2021 Category: Gastroenterology Source Type: research

Oral antibiotics and mechanical bowel preps: do they have to come together?
(Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - February 18, 2021 Category: Gastroenterology Source Type: research

Rate of dissemination and prognosis in early and advanced stage colorectal cancer based on microsatellite instability status: systematic review and meta-analysis
ConclusionsMSI-H CRC was associated with an overall survival benefit with a lower rate of dissemination. Survival benefit was clearly evident in both stage II and III CRC, but MSI-H was neither a robust prognostic marker in stage I nor stage IV CRC without immunotherapy. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - February 18, 2021 Category: Gastroenterology Source Type: research

The effect of vitamin D on the occurrence and development of colorectal cancer: a systematic review and meta-analysis
ConclusionThis meta-analysis demonstrates that vitamin D not only has a positive impact on the incidence of CRC from either the dietary or supplemental sources but also benefits clinical outcomes and improves the long-term survival of CRC patients. However, further studies are recommended to clarify the above phenomena. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - February 17, 2021 Category: Gastroenterology Source Type: research

Long-term impacts of appendectomy associated with increased incidence of inflammatory bowel disease, infection, and colorectal cancer
ConclusionPatients who underwent appendectomy may be at increased risk for developing Crohn ’s disease, ulcerative colitis,Clostridium difficile infection, sepsis, and colorectal cancer. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - February 16, 2021 Category: Gastroenterology Source Type: research

Does aspirin reduce the incidence, recurrence, and mortality of colorectal cancer? A meta-analysis of randomized clinical trials
ConclusionsThis meta-analysis of randomized controlled trial data indicates that aspirin reduces the overall risk of recurrence and mortality of CRC and/or colorectal adenomas. Incidence of CRC was also reduced with low-dose aspirin. The emerging evidence on aspirin ’s cancer protection role highlights an exciting time for cancer prevention through low-cost interventions.Trial registrationClinicaltrials.gov no: CRD42020208852; August 18, 2020;https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020208852). (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - February 16, 2021 Category: Gastroenterology Source Type: research

The comparison of FOLFOX regimens with different doses of 5-FU for the adjuvant treatment of colorectal cancer: a multicenter study
ConclusionIn the adjuvant treatment of stage III CRC patients, three different 5-FU administration types in FOLFOX combination treatment can be used with similar efficiency and manageable toxicity. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - February 14, 2021 Category: Gastroenterology Source Type: research

Comparing functional outcomes between transanal total mesorectal excision (TaTME) and laparoscopic total mesorectal excision (LaTME) for rectal cancer: a systematic review and meta-analysis
ConclusionThis review corroborates findings from previous studies in showing that the transanal approach is not associated with increased anal sphincter damage. Further prospective clinical trials are needed in this field of research. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - February 13, 2021 Category: Gastroenterology Source Type: research

Fistulectomy and endorectal advancement flap repair for cryptoglandular anal fistula: recurrence and functional outcome over 10 years of follow-up
AbstractPurposeTo examine long-term recurrence and anal continence of patients with anal fistula treated by fistulectomy and endorectal advancement flap repair.MethodRetrospective analysis of a prospective cohort of 115 patients (77.4% males, mean age 48.9 years) requiring 130 procedures, with a minimum follow-up of 10 years. Recurrence included reappearance of fistula after wound healing or presence of an abscess or chronic suppuration in the operated area at follow-up. Fecal incontinence was evaluated by the Cleveland Clinic Florida (CCF-FI) fecal incontinence scoring system.ResultsThe mean and SD duration of the follow-...
Source: International Journal of Colorectal Disease - February 12, 2021 Category: Gastroenterology Source Type: research

Same-day discharge after appendectomy for acute appendicitis: a systematic review and meta-analysis
ConclusionThis study suggests that same-day discharge after laparoscopic appendectomy for uncomplicated appendicitis is safe without an increased risk of readmission, complications, or unplanned hospital visits. Hence, same-day discharge may be further encouraged in selected patients.Trial registrationPROSPERO registration no. CRD42018115948 (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - February 11, 2021 Category: Gastroenterology Source Type: research

A multicenter, propensity score-matched cohort study about short-term and long-term outcomes after laparoscopic versus open surgery for locally advanced rectal cancer
This study evaluated the results of laparoscopic surgery (LAP) compared to open surgery (OP) for locally advanced mid-to-lower rectal cancer.MethodsFrom February 2008 to December 2014, we collected patient data with clinical stage II/III mid-to-lower rectal cancer who underwent resection with LAP or OP at 13 institutions associated with the Yokohama Clinical Oncology Group (YCOG). The short-term outcomes and long-term prognoses associated with LAP and OP were analyzed after adjusting for the patients ’ backgrounds using propensity score matching.ResultsAmong 1091 eligible cases, a propensity score matching with six c...
Source: International Journal of Colorectal Disease - February 11, 2021 Category: Gastroenterology Source Type: research

Long-term cost and complications of surgery in patients with ulcerative colitis: a claims data analysis
AbstractObjectivesUse claims data to assess healthcare resource utilization (HCRU) and cost for patients with ulcerative colitis (UC) who had surgery and patients who did not.MethodsUC patients from a German health insurance were included between 01/01/2010 –31/12/2017. Patients with proctocolectomy or colectomy between 01/07/2010 and 31/12/2014 were identified, and surgery date was set as index. For patients with IPAA, the last surgery in the 6 months was taken as index. Non-surgery patients received random index. After propensity score matching, UC -related HCRU and cost were observed for three years post-index.Res...
Source: International Journal of Colorectal Disease - February 10, 2021 Category: Gastroenterology Source Type: research

C-reactive protein can predict anastomotic leak in colorectal surgery: a systematic review and meta-analysis
AbstractBackgroundAnastomotic leakage (AL) is one of the most significant complications after colorectal surgery, affecting length of stay, patient morbidity, mortality, and long-term oncological outcome. Serum C-reactive protein (CRP) level rises in infective and inflammatory states. Elevated CRP has been shown to be associated with anastomotic leak.ObjectivePerform a meta-analysis of current CRP data in AL after colorectal surgery.Data sourcesMEDLINE, EMBASE, CINAHL, CENTRAL databasesStudy selectionComparative studies studying serum CRP levels in adult patients with and without AL after colorectal surgery.Intervention(s)...
Source: International Journal of Colorectal Disease - February 8, 2021 Category: Gastroenterology Source Type: research

Initial experience of preoperative short-course radiotherapy followed by oxaliplatin-based consolidation chemotherapy for locally advanced rectal cancer
ConclusionPreoperative SCRT followed by oxaliplatin-based consolidation chemotherapy showed acceptable toxicity and feasibility in patients with LARC. Prospective randomized trials are warranted to verify the efficacy and safety of this treatment strategy compared with conventional long-course concurrent chemoradiotherapy. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - February 6, 2021 Category: Gastroenterology Source Type: research

Use of a standardized discharge checklist with daily post-operative C-reactive protein monitoring does not impact readmission rates after colon and rectal surgery
ConclusionsThe institution of a “discharge checklist” did not impact post-operative hospital readmissions. Not only were readmissions unchanged by the use of a CRP threshold at discharge, but CRP levels at the time of discharge were not associated with readmissions. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - February 5, 2021 Category: Gastroenterology Source Type: research

Therapeutic significance of D3 dissection for low rectal cancer: a comparison of dissections between the lateral pelvic lymph nodes and the lymph nodes along the root of the inferior mesenteric artery in a multicenter retrospective cohort study
This study aimed to clarify the therapeutic significance of dissection of the LPLN in comparison to that of dissection of the 253 LN for low rectal cancer.MethodsWe retrospectively evaluated 3508 patients with treatment-na ïve stage I–III low rectal cancer who underwent mesorectal excision between 1997 and 2012. They were identified from the Japanese Study Group for Postoperative Follow-Up of Colorectal Cancer database. The rates of metastasis, survival, and therapeutic value index (5-year overall survival (OS) rat e multiplied by metastatic rate for lymph node metastasis) were compared between LPLN and 253 LN.R...
Source: International Journal of Colorectal Disease - February 3, 2021 Category: Gastroenterology Source Type: research

The development of a faecal incontinence core outcome set: an international Delphi study protocol
This study protocol describes the development of a European COS to improve reliability and consistency of outcome reporting in FI studies, thereby improving evidence synthesis and patient care.Trial registrationThis project has been registered in the COMET database on the 1st of April 2020, available athttp://www.comet-initiative.org/Studies/Details/1554. The systematic review has been registered on the PROSPERO database on the 31st of August 2020, available athttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=202020&VersionID=1381336. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - February 2, 2021 Category: Gastroenterology Source Type: research

Study protocol: a multicenter randomized controlled trial to evaluate the length of hospital stay of intracorporeal versus extracorporeal anastomosis in laparoscopic colectomy for colon cancer (CONNECT study)
ConclusionsThis RCT will compare the postoperative length of stay between IA and EA in twice the number of cases of previous RCTs. Concurrently, although as a secondary purpose, this will be the first study to compare IEEA and ISSA.Trial registration: This trial was registered with the UMIN Clinical Trials Registry in September 2020 as UMIN000041565. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - February 2, 2021 Category: Gastroenterology Source Type: research

Perineal wound complication risk factors and effects on survival after abdominoperineal resection of rectal cancer: a single-centre retrospective study
ConclusionProlonged operative time increases the risk of PWCs, and patients with PWCs have a lower long-term survival rate than patients without PWCs. Therefore, surgeons should aim to reduce the operative time to minimise the risk of PWC in patients undergoing APR for rectal cancer. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - February 2, 2021 Category: Gastroenterology Source Type: research

Surgical management of Crohn ’s disease: a state of the art review
ConclusionSurgical management of Crohn ’s disease remains challenging and is dependent on disease location and severity. Indication and timing of surgery should always be discussed in a multidisciplinary team. It seems that early surgery is gradually going to play a more important role in the multidisciplinary management of Crohn’s d isease rather than being a last resort therapy. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - February 2, 2021 Category: Gastroenterology Source Type: research

Prognostic factors for stage III colon cancer in patients 80 years of age and older
The objective of this study was to assess the factors predictive of poor prognosis in elderly patients with stage III colon cancer.MethodsA retrospective review of demographic, pathologic, treatment, and outcome data from 308 patients with stage III colon adenocarcinoma who had undergone surgery between 2007 and 2014 was conducted. A proportional hazards model was used to assess the association of prognostic factors with disease-free survival (DFS) and overall survival (OS).ResultsThe 5-year survival rate was 34.4% (95% CI 27.1 –39.8%) and Charlson comorbidity index was a significant predictor of death (p 
Source: International Journal of Colorectal Disease - February 2, 2021 Category: Gastroenterology Source Type: research

Effective dissection for rectal cancer with lateral lymph node metastasis based on prognostic factors and recurrence type
ConclusionThe therapeutic benefit of resection was high, especially in patients with ≤ 3 positive lateral lymph nodes, one-sided bilateral lymph node areas, and positive nodes localized near the internal iliac artery. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - February 1, 2021 Category: Gastroenterology Source Type: research

Radiofrequency in the treatment of fecal incontinence should no longer be recommended
(Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - February 1, 2021 Category: Gastroenterology Source Type: research

Nomogram for predicting occurrence and prognosis of liver metastasis in colorectal cancer: a population-based study
ConclusionLM is highly prevalent in CRC patients. Nomogram basing on the risk and prognostic factors for synchronous LM was proved to have good performance for predicting the probability of LM occurrence and prognosis. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - January 11, 2021 Category: Gastroenterology Source Type: research

A systemic review and metaanalysis of postoperative outcomes in urgent and elective bowel resection in patients with Crohn ’s disease
ConclusionUrgent bowel resection in patients with CD is associated with higher risk of overall postoperative complications and IASCs. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - January 11, 2021 Category: Gastroenterology Source Type: research

Association between serum bilirubin and mucosal healing among Japanese patients with ulcerative colitis: a cross-sectional study
ConclusionsAmong Japanese patients with UC, serum indirect bilirubin, but not total bilirubin, was significantly positively associated with MH but not clinical remission. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - January 11, 2021 Category: Gastroenterology Source Type: research

Impact of oral antibiotic prophylaxis on surgical site infection after rectal surgery: results of randomized trial
ConclusionOral-parenteral AP significantly reduced the risk of SSI following elective rectal surgery. Bacterial contamination of the pelvic cavity ≥ 105 CFU at the end of surgery and oral antimicrobial prophylaxis were independent risk factors of SSI. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - January 11, 2021 Category: Gastroenterology Source Type: research

Comparison of hyperspectral imaging and fluorescence angiography for the determination of the transection margin in colorectal resections —a comparative study
ConclusionHyperspectral imaging and fluorescence angiography provide similar results in determining the perfusion border. Both methods allow a good and safe visualization of the blood perfusion at the central resection margin to create a well-perfused anastomosis.Trial registrationThis study was registered atClinicaltrials.gov (NCT04226781) on January 13, 2020. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - January 11, 2021 Category: Gastroenterology Source Type: research

The incidence, risk factors, and new prediction score for fluorescence abnormalities of near-infrared imaging using indocyanine green in laparoscopic low anterior resection for rectal cancer
ConclusionThe incidence of fluorescence abnormalities in laparoscopic LAR was 5.4%. If theFAPS is used, thePpPM may be set from the viewpoint of the blood perfusion.Trial registrationJapanese Clinical Trials Registry: UMIN000032654 (http://www.umin.ac.jp/ctr/index.htm). (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - January 11, 2021 Category: Gastroenterology Source Type: research

Surgical resection does not avoid the risk of diverticulitis recurrence —a systematic review of risk factors
AbstractPurposeFifteen percent of patients undergoing elective sigmoidectomy will present a diverticulitis recurrence, which is associated with significant costs and morbidity. We aimed to systematically review the risk factors associated with recurrence after elective sigmoidectomy.MethodsPubMed/MEDLINE, Embase, Cochrane, and Web of Science were searched for studies published until May 1, 2020. Original studies were included if (i) they included patients undergoing sigmoidectomy for diverticular disease, (ii) they reported postoperative recurrent diverticulitis, and (iii) they analyzed ≥ 1 variable associated with recu...
Source: International Journal of Colorectal Disease - January 11, 2021 Category: Gastroenterology Source Type: research

IL6 genetic variants haplotype is associated with susceptibility and disease activity but not with therapy response in patients with inflammatory bowel disease
ConclusionThe G/C haplotype (recessive model) was associated with susceptibility to UC but not to CD. However, the G/C haplotype (dominant model) was associated with the endoscopic activity of CD. Moreover, theseIL6 variants did not predict the TNF- α inhibitor therapy response. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - January 11, 2021 Category: Gastroenterology Source Type: research

Risk factors and incidence of 90-day readmission for diverticulitis after an acute diverticulitis index admission
AbstractObjectivesAcute diverticulitis is the third most frequent cause of gastrointestinal admission in the USA. We sought to determine the incidence of recurrence within a 90-day period and determine its impact on mortality and hospital utilization.MethodsNationwide Readmission Database (NRD) 2016 was used to identify patients ≥ 18 years old with a principal diagnosis of acute diverticulitis who were readmitted for recurrence within 90 days. The primary outcome was 90-day readmission rate for acute diverticulitis, and predictors were analyzed using a multivariate regression analysis. Secondary outcome...
Source: International Journal of Colorectal Disease - January 11, 2021 Category: Gastroenterology Source Type: research

Evaluating the efficacy of treatment options for anal intraepithelial neoplasia: a systematic review
ConclusionsAlthough the theory persists that by inducing the regression of AIN, we may be able to reduce the risk of ASCC, there was no clinical evidence within the literature advocating that treating AIN does prevent ASCC. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - January 11, 2021 Category: Gastroenterology Source Type: research