Use of tryptic peptide MALDI mass spectrometry imaging to identify the spatial proteomic landscape of colorectal cancer liver metastases
This study utilised matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI) in combination with liquid chromatography-tandem mass spectrometry (LC-MS/MS) to spatially map the CRLM tumour proteome. CRLM tissue microarrays (TMAs) of 84 patients were analysed using tryptic peptide MALDI-MSI to spatially monitor peptide abundances across CRLM tissues. Abundance of peptides was compared between tumour vs stroma, male vs female and across three groups of patients based on overall survival (0-3 years, 4-6 years, and 7+ years). Peptides were then characterised and matched using LC-MS/MS. A total of 471 po...
Source: Clinical Colorectal Cancer - March 16, 2024 Category: Cancer & Oncology Authors: Celine Man Ying Li Matthew T Briggs Yea-Rin Lee Teresa Tin Clifford Young John Pierides Gurjeet Kaur Paul Drew Guy J Maddern Peter Hoffmann Manuela Klingler-Hoffmann Kevin Fenix Source Type: research

The cholesterol biosynthesis enzyme FAXDC2 couples Wnt/ β-catenin to RTK/MAPK signaling
J Clin Invest. 2024 Jan 23;134(6):e171222. doi: 10.1172/JCI171222.ABSTRACTWnts, cholesterol, and MAPK signaling are essential for development and adult homeostasis. Here, we report that fatty acid hydroxylase domain containing 2 (FAXDC2), a previously uncharacterized enzyme, functions as a methyl sterol oxidase catalyzing C4 demethylation in the Kandutsch-Russell branch of the cholesterol biosynthesis pathway. FAXDC2, a paralog of MSMO1, regulated the abundance of the specific C4-methyl sterols lophenol and dihydro-T-MAS. Highlighting its clinical relevance, FAXDC2 was repressed in Wnt/β-catenin-high cancer xenografts, in...
Source: Clinical Colorectal Cancer - March 15, 2024 Category: Cancer & Oncology Authors: Babita Madan Shawn R Wadia Siddhi Patnaik Nathan Harmston Emile Tan Iain Bee Huat Tan W David Nes Enrico Petretto David M Virshup Source Type: research

Single-cell sequencing reveals alterations in the peripheral blood mononuclear cell landscape and monocyte status during colorectal adenocarcinoma formation
Clin Transl Med. 2024 Mar;14(3):e1609. doi: 10.1002/ctm2.1609.NO ABSTRACTPMID:38488463 | PMC:PMC10941536 | DOI:10.1002/ctm2.1609 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 15, 2024 Category: Cancer & Oncology Authors: Jiasheng Xu Yeting Hu Jie Zhao Xiangxing Kong Sijian Xia Siqi Dai Lei Ding Tongtong Bu Yue Cao Manjiao Liu Linlin Yan Qian Xiao Hao Guo Ying Yuan Dong Xu Kefeng Ding Source Type: research

Racial Disparities in Receipt of Guideline-Concordant Care for Early-Onset Colorectal Cancer-We Must Do Better
J Clin Oncol. 2024 Mar 15:JCO2302186. doi: 10.1200/JCO.23.02186. Online ahead of print.NO ABSTRACTPMID:38489553 | DOI:10.1200/JCO.23.02186 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 15, 2024 Category: Cancer & Oncology Authors: Winta T Mehtsun Samir Gupta Source Type: research

Risk of Cancer in Patients with Diverticular Disease: A Population-based Cohort Study
CONCLUSIONS: Our findings show an increased long-term relative risk of cancer following a diagnosis of DD. These findings are likely due to prevalence of numerous risk factors in DD patients that confer an increased risk of cancer. The decreased relative risk of colorectal cancer might be explained by an increased likelihood of DD patients undergoing colonoscopy with polypectomy.PMID:38490316 | DOI:10.1016/j.cgh.2024.02.024 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 15, 2024 Category: Cancer & Oncology Authors: Frederikke S Troelsen D óra K Farkas Rune Erichsen Lisa L Strate John A Baron Henrik T S ørensen Source Type: research

The cholesterol biosynthesis enzyme FAXDC2 couples Wnt/ β-catenin to RTK/MAPK signaling
J Clin Invest. 2024 Jan 23;134(6):e171222. doi: 10.1172/JCI171222.ABSTRACTWnts, cholesterol, and MAPK signaling are essential for development and adult homeostasis. Here, we report that fatty acid hydroxylase domain containing 2 (FAXDC2), a previously uncharacterized enzyme, functions as a methyl sterol oxidase catalyzing C4 demethylation in the Kandutsch-Russell branch of the cholesterol biosynthesis pathway. FAXDC2, a paralog of MSMO1, regulated the abundance of the specific C4-methyl sterols lophenol and dihydro-T-MAS. Highlighting its clinical relevance, FAXDC2 was repressed in Wnt/β-catenin-high cancer xenografts, in...
Source: Clinical Colorectal Cancer - March 15, 2024 Category: Cancer & Oncology Authors: Babita Madan Shawn R Wadia Siddhi Patnaik Nathan Harmston Emile Tan Iain Bee Huat Tan W David Nes Enrico Petretto David M Virshup Source Type: research

Single-cell sequencing reveals alterations in the peripheral blood mononuclear cell landscape and monocyte status during colorectal adenocarcinoma formation
Clin Transl Med. 2024 Mar;14(3):e1609. doi: 10.1002/ctm2.1609.NO ABSTRACTPMID:38488463 | DOI:10.1002/ctm2.1609 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 15, 2024 Category: Cancer & Oncology Authors: Jiasheng Xu Yeting Hu Jie Zhao Xiangxing Kong Sijian Xia Siqi Dai Lei Ding Tongtong Bu Yue Cao Manjiao Liu Linlin Yan Qian Xiao Hao Guo Ying Yuan Dong Xu Kefeng Ding Source Type: research

Racial Disparities in Receipt of Guideline-Concordant Care for Early-Onset Colorectal Cancer-We Must Do Better
J Clin Oncol. 2024 Mar 15:JCO2302186. doi: 10.1200/JCO.23.02186. Online ahead of print.NO ABSTRACTPMID:38489553 | DOI:10.1200/JCO.23.02186 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 15, 2024 Category: Cancer & Oncology Authors: Winta T Mehtsun Samir Gupta Source Type: research

Risk of Cancer in Patients with Diverticular Disease: A Population-based Cohort Study
CONCLUSIONS: Our findings show an increased long-term relative risk of cancer following a diagnosis of DD. These findings are likely due to prevalence of numerous risk factors in DD patients that confer an increased risk of cancer. The decreased relative risk of colorectal cancer might be explained by an increased likelihood of DD patients undergoing colonoscopy with polypectomy.PMID:38490316 | DOI:10.1016/j.cgh.2024.02.024 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 15, 2024 Category: Cancer & Oncology Authors: Frederikke S Troelsen D óra K Farkas Rune Erichsen Lisa L Strate John A Baron Henrik T S ørensen Source Type: research

Type 2 diabetes mellitus and post-colonoscopy colorectal cancer: clinical and molecular characteristics and survival
CONCLUSION: The increased prevalence of proximally located PCCRCs and the poorer survival may suggest overlooked colorectal lesions as a predominant explanation for T2D-related PCCRC, although altered tumor progression cannot be ruled out.PMID:38483686 | DOI:10.1007/s10552-024-01861-9 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 14, 2024 Category: Cancer & Oncology Authors: Mette L Boysen Frederikke S Troelsen Henrik T S ørensen Rune Erichsen Source Type: research

Prognostic and Predictive Value of Immunoscore in Stage III Colorectal Cancer: Pooled Analysis of Cases From the SCOT and IDEA-HORG Studies
CONCLUSION: IS is prognostic in stage III CRC treated with FOLFOX or CAPOX, including within clinically relevant tumor subgroups. Possible variation in IS prognostic value by age and MMR status, and prediction of benefit from extended adjuvant therapy merit validation.PMID:38484206 | DOI:10.1200/JCO.23.01648 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 14, 2024 Category: Cancer & Oncology Authors: Enric Domingo Caroline Kelly Jennifer Hay Owen Sansom Noori Maka Karin Oien Tim Iveson Mark Saunders Rachel Kerr Ian Tomlinson Joanne Edwards Andrea Harkin Marta Nowak Viktor Koelzer Alistair Easton Ioannis Boukovinas Eleni Moustou Ippokratis Messaritakis Source Type: research

Type 2 diabetes mellitus and post-colonoscopy colorectal cancer: clinical and molecular characteristics and survival
CONCLUSION: The increased prevalence of proximally located PCCRCs and the poorer survival may suggest overlooked colorectal lesions as a predominant explanation for T2D-related PCCRC, although altered tumor progression cannot be ruled out.PMID:38483686 | DOI:10.1007/s10552-024-01861-9 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 14, 2024 Category: Cancer & Oncology Authors: Mette L Boysen Frederikke S Troelsen Henrik T S ørensen Rune Erichsen Source Type: research

Prognostic and Predictive Value of Immunoscore in Stage III Colorectal Cancer: Pooled Analysis of Cases From the SCOT and IDEA-HORG Studies
CONCLUSION: IS is prognostic in stage III CRC treated with FOLFOX or CAPOX, including within clinically relevant tumor subgroups. Possible variation in IS prognostic value by age and MMR status, and prediction of benefit from extended adjuvant therapy merit validation.PMID:38484206 | DOI:10.1200/JCO.23.01648 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 14, 2024 Category: Cancer & Oncology Authors: Enric Domingo Caroline Kelly Jennifer Hay Owen Sansom Noori Maka Karin Oien Tim Iveson Mark Saunders Rachel Kerr Ian Tomlinson Joanne Edwards Andrea Harkin Marta Nowak Viktor Koelzer Alistair Easton Ioannis Boukovinas Eleni Moustou Ippokratis Messaritakis Source Type: research

Fournier's gangrene due to rectal cancer: A case report
Mol Clin Oncol. 2024 Feb 12;20(4):30. doi: 10.3892/mco.2024.2728. eCollection 2024 Apr.ABSTRACTFournier's gangrene (FG) is an extremely rare necrotizing fasciitis that is insidious, rapidly spreading and life-threatening. FGs due to rectal cancer occur rarely and there is a lack of clinical reference. In the present study, a severe FG due to rectal cancer perforation was described and the features of this rare disease were summarized with a literature review. A 57-year-old man was admitted because of rectal cancer-induced FG. The patient was misdiagnosed with extensive perianal abscess until the intraoperative biopsy confi...
Source: Clinical Colorectal Cancer - March 13, 2024 Category: Cancer & Oncology Authors: Sen Hou Baosen Cheng Kai Shen Zhidong Gao Fan Liu Yingjiang Ye Source Type: research

A comprehensive multi-omics analysis identifies a robust scoring system for cancer-associated fibroblasts and intervention targets in colorectal cancer
CONCLUSION: We constructed a robust CAFGs score system with clinical significance using multiple CRC cohorts. In addition, we identified several molecules related to CAF identity and function that could be potential intervention targets for CRC patients.PMID:38478111 | DOI:10.1007/s00432-023-05548-7 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 13, 2024 Category: Cancer & Oncology Authors: Feng Wang Zhenlin Li Tianlei Xu Qian Zhang Tianyi Ma Sijia Li Xiaohui Wang Source Type: research