Comparison of Post-Operative Outcomes of Right Colectomy between Crohn's Disease and Adenocarcinoma of the Right Colon: A Retrospective Cohort Study
Conclusions: This study has shown that post-operative complication rate is similar for right colectomy in CD and CRC. However, Crohn's disease patients did have a higher leak rate.PMID:38792351 | DOI:10.3390/jcm13102809 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - May 25, 2024 Category: Cancer & Oncology Authors: Naama Bursztyn Edden Slomowitz Dan Assaf Ehab Haj Yahia Ilan Kent Nir Wasserberg Shmuel Avital Ian White Source Type: research

Clinicopathological Differences between Right and Left Colorectal Cancer by Sex
Conclusions: The clinicopathologic characteristics of CRC vary according to the location and sex. Therefore, sex must be considered as a fundamental characteristic of personalized treatment.PMID:38792352 | DOI:10.3390/jcm13102810 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - May 25, 2024 Category: Cancer & Oncology Authors: Hannah Ra Soyeon Jeong Hannah Lee Jun-Won Chung Kyoung Oh Kim Won-Suk Lee Jisup Kim Kwang An Kwon Jung Ho Kim Source Type: research

Predictive Score for Advanced Colorectal Neoplasia Based on Cardiovascular and Colorectal Cancer Risk Factors
Conclusions: The newly validated CRNAS has a better discriminatory capacity to predict advanced CRN than cardiovascular scores. It may be useful for selecting candidates for screening colonoscopy, especially in those with cardiovascular risk factors.PMID:38792429 | DOI:10.3390/jcm13102887 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - May 25, 2024 Category: Cancer & Oncology Authors: Lara M Ruiz-Belmonte Patricia Carrera-Lasfuentes Alberto Cebollada-Solanas Carmelo Scarpignato Angel Lanas Carla J Gargallo-Puyuelo Source Type: research

The Yield of Colonoscopy in the Evaluation of Constipation: An Age-Based Analysis of Outcome
Conclusions: Constipation did not confer an increased risk for CRC or polyps, among any age groups, except for a potential signal of elevated CRC risk in patients older than 80; additionally, it was associated with higher rates of IBD in younger patients.PMID:38792451 | DOI:10.3390/jcm13102910 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - May 25, 2024 Category: Cancer & Oncology Authors: Fadi Abu Baker Amir Mari Randa Taher Dorin Nicola Oren Gal Abdel-Rauf Zeina Source Type: research

Early Single-Center Experience of DaVinci() Single-Port (SP) Robotic Surgery in Colorectal Patients
Conclusions: Overall, our experience with single-port robotic colorectal surgery has been promising. With only one patient with additional port for drain insertion, all nine patients underwent SP-robotic surgery with single incision for colon as well as rectal surgeries. Compared to an average postoperative length of stay of 6.5-8 days in laparoscopic colorectal surgeries reported in literature, SP-robotic surgery 33showed faster recovery of 6 days highlighting its benefits in patient recovery and satisfaction.PMID:38792530 | DOI:10.3390/jcm13102989 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - May 25, 2024 Category: Cancer & Oncology Authors: Hye Jung Cho Woo Ram Kim Source Type: research

Role of dietary nutrients and metabolism in colorectal cancer
Asia Pac J Clin Nutr. 2024 Jun;33(2):153-161. doi: 10.6133/apjcn.202406_33(2).0002.ABSTRACTColorectal cancer (CRC) is one of the most common malignancies and the leading causes of cancer related deaths worldwide. The development of CRC is driven by a combination of genetic and environmental factors. There is growing evidence that changes in dietary nutrition may modulate the CRC risk, and protective effects on the risk of developing CRC have been advocated for specific nutrients such as glucose, amino acids, lipid, vitamins, micronutrients and prebiotics. Metabolic crosstalk between tumor cells, tumor microenvironment comp...
Source: Clinical Colorectal Cancer - May 25, 2024 Category: Cancer & Oncology Authors: Jinjun Ye Xing Bao Jiufeng Wei Yuanpeng Zhang Yu Liu Le Xin Source Type: research

Establishment of a neutrophil extracellular trap-related prognostic signature for colorectal cancer liver metastasis and expression validation of CYP4F3
Clin Exp Med. 2024 May 25;24(1):112. doi: 10.1007/s10238-024-01378-0.ABSTRACTLiver metastasis stands as the primary contributor to mortality among patients diagnosed with colorectal cancer (CRC). Neutrophil extracellular traps (NETs) emerge as pivotal players in the progression and metastasis of cancer, showcasing promise as prognostic biomarkers. Our objective is to formulate a predictive model grounded in genes associated with neutrophil extracellular traps and identify novel therapeutic targets for combating CRLM. We sourced gene expression profiles from the Gene Expression Omnibus (GEO) database. Neutrophil extracellul...
Source: Clinical Colorectal Cancer - May 25, 2024 Category: Cancer & Oncology Authors: Xiao-Li Tang Zi-Yang Xu Jiao Guan Jing Yao Xiao-Long Tang Zun-Qiang Zhou Zheng-Yun Zhang Source Type: research

The nuclear export protein exportin-1 in solid malignant tumours: From biology to clinical trials
CONCLUSION: XPO1 inhibition has emerged as a promising therapeutic strategy in the fight against cancer, offering a novel approach to targeting tumorigenic processes and overcoming drug resistance. SINE compounds have demonstrated efficacy in a wide range of solid tumours, and ongoing research is focused on optimizing their use, identifying response biomarkers, and developing effective combination therapies.KEY POINTS: Exportin-1 (XPO1) plays a critical role in mediating nucleocytoplasmic transport and cell cycle. XPO1 dysfunction promotes tumourigenesis and drug resistance within solid tumours. The therapeutic potential a...
Source: Clinical Colorectal Cancer - May 24, 2024 Category: Cancer & Oncology Authors: Chuanxi Lai Lingna Xu Sheng Dai Source Type: research

Use of Natural Language Processing to Infer Sites of Metastatic Disease From Radiology Reports at Scale
CONCLUSION: We developed an IE system that accurately infers metastatic sites in multiple primary cancers from radiology reports. It has explainable methods and performs better than some clinical LLMs. The inferred metastatic phenotypes could enhance cancer research databases and clinical trial matching, and identify potential patients for oligometastatic interventions.PMID:38788166 | DOI:10.1200/CCI.23.00122 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - May 24, 2024 Category: Cancer & Oncology Authors: See Boon Tay Guat Hwa Low Gillian Jing En Wong Han Jieh Tey Fun Loon Leong Constance Li Melvin Lee Kiang Chua Daniel Shao Weng Tan Choon Hua Thng Iain Bee Huat Tan Ryan Shea Ying Cong Tan Source Type: research

Visceral fat and clinical outcome in patients receiving first-line chemotherapy with bevacizumab for metastatic colorectal cancer
CONCLUSION: This study demonstrates that a high visceral fat volume is associated with better outcome in patients receiving first-line bevacizumab-based chemotherapy for metastatic colorectal cancer.PMID:38788975 | DOI:10.1016/j.clinre.2024.102380 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - May 24, 2024 Category: Cancer & Oncology Authors: Nicolas Cazeneuve Olivier Bouch é Julie Leger Christophe Borg Catherine Labbe-Devilliers Olivier Lucidarme Jean-Pierre Tasu Sylvain Manfredi Christophe Aub é Herv é Trillaud Philippe Manzoni Claude Marcus Eric Terrebonne Jean-Yves Douillard Romain Chau Source Type: research

Potential for Metastasis and Recurrence in Colorectal Carcinoma In Situ: A Retrospective Analysis of 1069 Patients
CONCLUSION: Contrary to previous assumptions, colorectal carcinoma in situ can potentially metastasize to lymph nodes and recur. Therefore, careful assessment at the time of diagnosis is crucial, recognizing the possibility of lymph node metastasis or recurrence. This approach is essential for accurately identifying instances of cancer recurrence and ensuring optimal oncological outcomes.PMID:38789338 | DOI:10.1016/j.clcc.2024.04.003 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - May 24, 2024 Category: Cancer & Oncology Authors: Seijong Kim Jung Kyong Shin Yoonah Park Jung Wook Huh Hee Cheol Kim Seong Hyeon Yun Woo Yong Lee Yong Beom Cho Source Type: research

The nuclear export protein exportin-1 in solid malignant tumours: From biology to clinical trials
CONCLUSION: XPO1 inhibition has emerged as a promising therapeutic strategy in the fight against cancer, offering a novel approach to targeting tumorigenic processes and overcoming drug resistance. SINE compounds have demonstrated efficacy in a wide range of solid tumours, and ongoing research is focused on optimizing their use, identifying response biomarkers, and developing effective combination therapies.KEY POINTS: Exportin-1 (XPO1) plays a critical role in mediating nucleocytoplasmic transport and cell cycle. XPO1 dysfunction promotes tumourigenesis and drug resistance within solid tumours. The therapeutic potential a...
Source: Clinical Colorectal Cancer - May 24, 2024 Category: Cancer & Oncology Authors: Chuanxi Lai Lingna Xu Sheng Dai Source Type: research

Use of Natural Language Processing to Infer Sites of Metastatic Disease From Radiology Reports at Scale
CONCLUSION: We developed an IE system that accurately infers metastatic sites in multiple primary cancers from radiology reports. It has explainable methods and performs better than some clinical LLMs. The inferred metastatic phenotypes could enhance cancer research databases and clinical trial matching, and identify potential patients for oligometastatic interventions.PMID:38788166 | DOI:10.1200/CCI.23.00122 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - May 24, 2024 Category: Cancer & Oncology Authors: See Boon Tay Guat Hwa Low Gillian Jing En Wong Han Jieh Tey Fun Loon Leong Constance Li Melvin Lee Kiang Chua Daniel Shao Weng Tan Choon Hua Thng Iain Bee Huat Tan Ryan Shea Ying Cong Tan Source Type: research

Visceral fat and clinical outcome in patients receiving first-line chemotherapy with bevacizumab for metastatic colorectal cancer
CONCLUSION: This study demonstrates that a high visceral fat volume is associated with better outcome in patients receiving first-line bevacizumab-based chemotherapy for metastatic colorectal cancer.PMID:38788975 | DOI:10.1016/j.clinre.2024.102380 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - May 24, 2024 Category: Cancer & Oncology Authors: Nicolas Cazeneuve Olivier Bouch é Julie Leger Christophe Borg Catherine Labbe-Devilliers Olivier Lucidarme Jean-Pierre Tasu Sylvain Manfredi Christophe Aub é Herv é Trillaud Philippe Manzoni Claude Marcus Eric Terrebonne Jean-Yves Douillard Romain Chau Source Type: research

Potential for Metastasis and Recurrence in Colorectal Carcinoma In Situ: A Retrospective Analysis of 1069 Patients
CONCLUSION: Contrary to previous assumptions, colorectal carcinoma in situ can potentially metastasize to lymph nodes and recur. Therefore, careful assessment at the time of diagnosis is crucial, recognizing the possibility of lymph node metastasis or recurrence. This approach is essential for accurately identifying instances of cancer recurrence and ensuring optimal oncological outcomes.PMID:38789338 | DOI:10.1016/j.clcc.2024.04.003 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - May 24, 2024 Category: Cancer & Oncology Authors: Seijong Kim Jung Kyong Shin Yoonah Park Jung Wook Huh Hee Cheol Kim Seong Hyeon Yun Woo Yong Lee Yong Beom Cho Source Type: research