Histopathological tumour microenvironment score independently predicts outcome in primary operable colorectal cancer
In conclusion, TMS represents a novel and clinically relevant method for subtyping CRC patients from a single H&E-stained tumour section.PMID:38650367 | DOI:10.1002/2056-4538.12374 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Phimmada Hatthakarnkul Kathryn Pennel Peter Alexander Hester van Wyk Antonia Roseweir Jitwadee Inthagard Jennifer Hay Ditte Andersen Noori Maka James Park Campbell Roxburgh Chanitra Thuwajit Donald McMillan Joanne Edwards Source Type: research
Human NLRC4 promotes cancer survival and is associated to type-I interferon signaling and immune infiltration
J Clin Invest. 2024 Apr 23:e166085. doi: 10.1172/JCI166085. Online ahead of print.ABSTRACTThe immune system can control cancer progression. However, even though some innate immune sensors of cellular stress are expressed intrinsically in epithelial cells, their potential role in cancer aggressiveness and subsequent overall survival in humans is mainly unknown. Here, we show that NLR family CARD Domain Containing 4 (NLRC4) is downregulated in epithelial tumor cells of colorectal cancer (CRC) patients by using spatial tissue imaging. Strikingly, only the loss of tumor NLRC4 but not stromal is associated with poor immune infi...
Source: Clinical Colorectal Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Charlotte Domblides Steven Crampton Hong Liu Juliet M Bartleson Annie Nguyen Claudia Champagne Emily E Landy Lindsey Spiker Christopher Proffitt Sunil Bhattarai Anissa P Grawe Matias Fuentealba Valenzuela Lydia Lartigue Isabelle Mahouche Jeremy Dupaul-Chi Source Type: research
Biomarker-oriented chemo-immunotherapy for advanced gastric cancer
Int J Clin Oncol. 2024 Apr 22. doi: 10.1007/s10147-024-02525-z. Online ahead of print.ABSTRACTThe biomarker-oriented chemo-immunotherapy is useful and promising in the development of new anticancer agents, since the responders can be enriched by selecting patients with biomarkers. Compared to colorectal and lung cancers, the development of biomarker-driven molecular-targeted therapeutics for gastric cancers has been straggled. However, several new biomarkers in gastric cancers have been discovered and clinical trials in enrichment design with certain biomarkers have been conducted. Therefore, there are currently several tr...
Source: Clinical Colorectal Cancer - April 22, 2024 Category: Cancer & Oncology Authors: Koji Kono Shotaro Nakajima Kosaku Mimura Source Type: research
The Impact of potential 'confounders' on the diagnostic sensitivity of circulating free DNA in management of FIT+ patients: a pilot study
J Clin Pathol. 2024 Apr 22:jcp-2024-209527. doi: 10.1136/jcp-2024-209527. Online ahead of print.ABSTRACTCell-free DNA (cfDNA) has long been established as a useful diagnostic and prognostic tool in a variety of clinical settings, ranging from infectious to cardiovascular and neoplastic diseases. However, non-neoplastic diseases can act as confounders impacting on the amount of cfDNA shed in bloodstream and on technical feasibility of tumour derived free circulating nucleic acids selecting patients with cancer. Here, we investigated the potential impact of other pathological processes in the clinical stratification of 637 F...
Source: Clinical Colorectal Cancer - April 22, 2024 Category: Cancer & Oncology Authors: Mauro Scimia Francesco Pepe Gianluca Russo Lucia Palumbo Umberto Malapelle Rachel Chuang Simone Scimia Michael Sha Hiromi Tanaka Shuo Shen David Chen Giancarlo Troncone Maria Antonia Bianco Source Type: research
Circ_0087851 suppresses colorectal cancer malignant progression through triggering miR-593-3p/BAP1-mediated ferroptosis
CONCLUSION: Circ_0087851 performed as a tumor suppressor and ferroptosis promoter by the miR-593-3p/BAP1 axis, providing novel biomarker and therapeutic target for the clinical management of CRC.PMID:38642144 | PMC:PMC11032280 | DOI:10.1007/s00432-024-05643-3 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 20, 2024 Category: Cancer & Oncology Authors: Ming Huang Ting Gao Xianyong Chen Junlei Yi Xuan Zhou Source Type: research
Characteristics and outcomes of cancer patients admitted to intensive care units in cancer specialized hospitals in China
CONCLUSION: Patients with lung cancer require more ICU care due to critical complications and the overall survival prognosis is poor. Colorectal cancer may benefit more from ICU management. This information may be considered in ICU admission and treatment strategies.PMID:38642154 | PMC:PMC11032264 | DOI:10.1007/s00432-024-05727-0 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 20, 2024 Category: Cancer & Oncology Authors: Wensheng Liu Dongmin Zhou Li Zhang Mingguang Huang Rongxi Quan Rui Xia Yong Ye Guoxing Zhang Zhuping Shen Cancer Critical Care Medicine Committee of the Chinese Anti-Cancer Association Source Type: research
Clinicopathological characteristics of Lynch-like syndrome
CONCLUSIONS: Distinguishing clinically between LS and LLS was challenging, but the incidence of neoplasms was higher in LS than in LLS, suggesting the need for different screening and surveillance methods for the two subtypes.PMID:38642190 | DOI:10.1007/s10147-024-02527-x (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 20, 2024 Category: Cancer & Oncology Authors: Sakiko Nakamori Misato Takao Akinari Takao Soichiro Natsume Takeru Iijima Ekumi Kojika Daisuke Nakano Kazushige Kawai Takuhiko Inokuchi Ai Fujimoto Makiko Urushibara Shin-Ichiro Horiguchi Hideyuki Ishida Tatsuro Yamaguchi Source Type: research
Cost-effectiveness analysis of fruquintinib in Chinese patients with refractory metastatic colorectal cancer
CONCLUSION: Fruquintinib emerges as a promising therapeutic option for refractory mCRC. However, its cost-effectiveness depends on selected willingness-to-pay (WTP) threshold. While the drug's ICER surpasses the WTP based on China's 2022 GDP per capita, it remains below the threshold set at three times the national GDP.PMID:38642249 | DOI:10.1007/s11096-024-01721-1 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 20, 2024 Category: Cancer & Oncology Authors: Zijia Huang Lingyan Zhou Hanrui Zheng Mei Zhan Source Type: research
Sequential RAS mutations evaluation in cell-free DNA of patients with tissue RAS wild-type metastatic colorectal cancer: the PERSEIDA (Cohort 2) study
CONCLUSIONS: The concordance rate between liquid and solid biopsies at baseline was very high, as previously reported, while our results suggest a considerable emergence of RAS mutations during disease progression. Thus, the dynamics of the genomic landscape in ctDNA may provide relevant information for the management of mCRC patients.PMID:38642257 | DOI:10.1007/s12094-024-03487-4 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 20, 2024 Category: Cancer & Oncology Authors: Manuel Valladares-Ayerbes Maria Jos é Safont Encarnaci ón González Flores Pilar Garc ía-Alfonso Enrique Aranda Ana-Maria L ópez Muñoz Esther Falc ó Ferrer Lu ís Cirera Nogueras Nuria Rodr íguez-Salas Jorge Aparicio Marta Llanos Mu ñoz Paola Patr Source Type: research
N6-methyladenosine-modified circSLCO1B3 promotes intrahepatic cholangiocarcinoma progression via regulating HOXC8 and PD-L1
CONCLUSIONS: Taken together, m6A-modified circSLCO1B3 was correlated with poor prognosis in ICC and promoted ICC progression not only by enhancing proliferation and metastasis via potentiating HOXC8 expression, but also by inducing immune evasion via antagonizing PD-L1 degradation. These results suggest that circSLCO1B3 is a potential prognostic marker and therapeutic target for ICC.PMID:38641828 | PMC:PMC11031933 | DOI:10.1186/s13046-024-03006-x (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 19, 2024 Category: Cancer & Oncology Authors: Jing Li Xiaohong Xu Kaihao Xu Xueliang Zhou Kunpeng Wu Yuan Yao Zaoqu Liu Chen Chen Ling Wang Zhenqiang Sun Dechao Jiao Xinwei Han Source Type: research
Bench-to-bedside imaging in brain metastases: a road to precision oncology
This article offers insight into the molecular biology underlying brain metastasis, its pathogenesis, imaging protocols, and algorithms. It also discusses disease-specific molecular imaging features, focusing on common tumors that spread to the brain, such as lung, breast, colorectal cancer, melanoma, and renal cell carcinoma. Additionally, it covers various targeted treatment options, criteria for assessing treatment response, and the role of artificial intelligence in diagnosing, managing, and predicting prognosis for patients with brain metastases.PMID:38637186 | DOI:10.1016/j.crad.2024.02.015 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 18, 2024 Category: Cancer & Oncology Authors: S Shukla A Karbhari S Rastogi U Agarwal P Rai A Mahajan Source Type: research
Bench-to-bedside imaging in brain metastases: a road to precision oncology
This article offers insight into the molecular biology underlying brain metastasis, its pathogenesis, imaging protocols, and algorithms. It also discusses disease-specific molecular imaging features, focusing on common tumors that spread to the brain, such as lung, breast, colorectal cancer, melanoma, and renal cell carcinoma. Additionally, it covers various targeted treatment options, criteria for assessing treatment response, and the role of artificial intelligence in diagnosing, managing, and predicting prognosis for patients with brain metastases.PMID:38637186 | DOI:10.1016/j.crad.2024.02.015 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 18, 2024 Category: Cancer & Oncology Authors: S Shukla A Karbhari S Rastogi U Agarwal P Rai A Mahajan Source Type: research
Single-cell transcriptomic landscape reveals distinct tumourigenesis and immune microenvironments in secondary radiation-exposed rectal cancer
Clin Transl Med. 2024 Apr;14(4):e1659. doi: 10.1002/ctm2.1659.NO ABSTRACTPMID:38629628 | PMC:PMC11022289 | DOI:10.1002/ctm2.1659 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Xu Guan Xiaoman Bi Ran Wei Zhixun Zhao Zhao Lu Zheng Jiang Xishan Wang Deng Wu Source Type: research
Single-cell transcriptomic landscape reveals distinct tumourigenesis and immune microenvironments in secondary radiation-exposed rectal cancer
Clin Transl Med. 2024 Apr;14(4):e1659. doi: 10.1002/ctm2.1659.NO ABSTRACTPMID:38629628 | DOI:10.1002/ctm2.1659 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Xu Guan Xiaoman Bi Ran Wei Zhixun Zhao Zhao Lu Zheng Jiang Xishan Wang Deng Wu Source Type: research
Correction: Decreased expression of prolyl hydroxylase 1 is associated with poor prognosis in colorectal cancers
J Cancer Res Clin Oncol. 2024 Apr 16;150(4):197. doi: 10.1007/s00432-024-05729-y.NO ABSTRACTPMID:38625411 | DOI:10.1007/s00432-024-05729-y (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 16, 2024 Category: Cancer & Oncology Authors: Nathaniel Melling Julia Grass Matthias Reeh Michael Tachezy Marco Blessmann Jakob R Izbicki Katharina Grupp Source Type: research
