Robotic-Assisted versus Laparoscopic Surgery for Rectal Cancer: An Analysis of Clinical and Financial Outcomes from a Tertiary Referral Center
Conclusions: In our study, robotic-assisted surgery for rectal cancer resulted in less severe and fewer total postoperative complications. Still, it was associated with higher surgery and inpatient costs. With increasing experience, the operative time may be reduced, and the postoperative recovery may be further accelerated, leading to reduced surgery and total inpatient costs.PMID:38542019 | PMC:PMC10971725 | DOI:10.3390/jcm13061795 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 28, 2024 Category: Cancer & Oncology Authors: Jasper Max Gebhardt Neno Werner Andrea Stroux Frank F örster Ioannis Pozios Claudia Seifarth Christian Schineis Benjamin Weixler Katharina Beyer Johannes Christian Lauscher Source Type: research
Urocortin-1 promotes colorectal cancer cell migration and proliferation and inhibits apoptosis via inhibition of the p53 signaling pathway
CONCLUSION: UCN-1 promotes migration and proliferation and inhibits apoptosis via inhibition of the p53 signaling pathway.PMID:38546882 | PMC:PMC10978644 | DOI:10.1007/s00432-024-05693-7 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 28, 2024 Category: Cancer & Oncology Authors: Xiaolan Guo Ya Li Xiangyu Chen Binghua Sun Xiaolan Guo Source Type: research
Association between Surrogate Markers of Insulin Resistance and the Incidence of Colorectal Cancer in Korea: A Nationwide Population-Based Study
Conclusions: In conclusion, the TyG index, TG/HDL-C ratio, and METS-IR were positively correlated with CRC incidence in Koreans.PMID:38541854 | DOI:10.3390/jcm13061628 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 28, 2024 Category: Cancer & Oncology Authors: Minkook Son Sang Yi Moon Myeongseok Koh Yeowool Kang Jong Yoon Lee Source Type: research
Circulating Tumor DNA (ctDNA) Clearance May Predict Treatment Response in Neoadjuvant Colorectal Cancer Management
Conclusions: This study highlights the potential utility of ctDNA and the need for prospective trials in the neoadjuvant setting to monitor treatment response and guide decisions on treatment duration.PMID:38541909 | DOI:10.3390/jcm13061684 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 28, 2024 Category: Cancer & Oncology Authors: Britney Niemann John Moise Michael Sestito Midhun Malla Kevin Train Douglas Murken Keri Mayers Emily Groves Mary Garland-Kledzik Source Type: research
Robotic-Assisted versus Laparoscopic Surgery for Rectal Cancer: An Analysis of Clinical and Financial Outcomes from a Tertiary Referral Center
Conclusions: In our study, robotic-assisted surgery for rectal cancer resulted in less severe and fewer total postoperative complications. Still, it was associated with higher surgery and inpatient costs. With increasing experience, the operative time may be reduced, and the postoperative recovery may be further accelerated, leading to reduced surgery and total inpatient costs.PMID:38542019 | DOI:10.3390/jcm13061795 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 28, 2024 Category: Cancer & Oncology Authors: Jasper Max Gebhardt Neno Werner Andrea Stroux Frank F örster Ioannis Pozios Claudia Seifarth Christian Schineis Benjamin Weixler Katharina Beyer Johannes Christian Lauscher Source Type: research
Urocortin-1 promotes colorectal cancer cell migration and proliferation and inhibits apoptosis via inhibition of the p53 signaling pathway
CONCLUSION: UCN-1 promotes migration and proliferation and inhibits apoptosis via inhibition of the p53 signaling pathway.PMID:38546882 | DOI:10.1007/s00432-024-05693-7 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 28, 2024 Category: Cancer & Oncology Authors: Xiaolan Guo Ya Li Xiangyu Chen Binghua Sun Xiaolan Guo Source Type: research
Prognostic impact of primary tumour location after curative resection in Stage I-III colorectal cancer: a single-centre retrospective study
CONCLUSIONS: In Stage I-III colorectal cancer without preoperative treatment, our results suggest that the three tumour sites (right-sided colon, left-sided colon or rectum) may have prognostic significance for recurrence-free survival and survival after recurrence, rather than sidedness alone.PMID:38535894 | DOI:10.1093/jjco/hyae035 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 27, 2024 Category: Cancer & Oncology Authors: Manabu Inoue Yukihide Kanemitsu Shunsuke Tsukamoto Konosuke Moritani Yasuyuki Takamizawa Hiroyuki Daiko Source Type: research
Impact of Broadening Trial Eligibility Criteria on the Inclusion of Patients With Brain Metastases in Cancer Clinical Trials: Time Series Analyses for 2012-2022
CONCLUSION: The ASCO/FoCR/FDA task force recommendations were associated with a shift in patterns of brain metastases exclusion criteria from conditionally excluded to not excluded. These findings demonstrate that the cancer clinical trial community has begun to change the way trials are written to be more inclusive.PMID:38537158 | DOI:10.1200/JCO.23.01777 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 27, 2024 Category: Cancer & Oncology Authors: Hong Xiao Riha Vaidya Dawn L Hershman Joseph M Unger Source Type: research
Prognostic impact of primary tumour location after curative resection in Stage I-III colorectal cancer: a single-centre retrospective study
CONCLUSIONS: In Stage I-III colorectal cancer without preoperative treatment, our results suggest that the three tumour sites (right-sided colon, left-sided colon or rectum) may have prognostic significance for recurrence-free survival and survival after recurrence, rather than sidedness alone.PMID:38535894 | DOI:10.1093/jjco/hyae035 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 27, 2024 Category: Cancer & Oncology Authors: Manabu Inoue Yukihide Kanemitsu Shunsuke Tsukamoto Konosuke Moritani Yasuyuki Takamizawa Hiroyuki Daiko Source Type: research
Impact of Broadening Trial Eligibility Criteria on the Inclusion of Patients With Brain Metastases in Cancer Clinical Trials: Time Series Analyses for 2012-2022
CONCLUSION: The ASCO/FoCR/FDA task force recommendations were associated with a shift in patterns of brain metastases exclusion criteria from conditionally excluded to not excluded. These findings demonstrate that the cancer clinical trial community has begun to change the way trials are written to be more inclusive.PMID:38537158 | DOI:10.1200/JCO.23.01777 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 27, 2024 Category: Cancer & Oncology Authors: Hong Xiao Riha Vaidya Dawn L Hershman Joseph M Unger Source Type: research
Racial Disparities in Low-Value Care in the Last Year of Life for Medicare Beneficiaries With Neurodegenerative Disease
This study evaluated racial disparities in the utilization of high-value and low-value care in the last year of life among Medicare beneficiaries with dementia or Parkinson disease.METHODS: This was a retrospective, population-based cohort analysis using data from North and South Carolina fee-for-service Medicare claims between 2013 and 2017. We created a decedent cohort of beneficiaries aged 50 years or older at diagnosis with dementia or Parkinson disease. Specific low-value utilization outcomes were selected from the Choosing Wisely initiative, including cancer screening, peripheral artery stenting, and feeding tube pla...
Source: Clinical Colorectal Cancer - March 25, 2024 Category: Cancer & Oncology Authors: Margarethe E Goetz Cassie B Ford Melissa A Greiner Amy Clark Kim G Johnson Brystana G Kaufman Sneha Mantri Ying Xian Richard J O'Brien Emily C O'Brien Jay B Lusk Source Type: research
Racial Disparities in Low-Value Care in the Last Year of Life for Medicare Beneficiaries With Neurodegenerative Disease
This study evaluated racial disparities in the utilization of high-value and low-value care in the last year of life among Medicare beneficiaries with dementia or Parkinson disease.METHODS: This was a retrospective, population-based cohort analysis using data from North and South Carolina fee-for-service Medicare claims between 2013 and 2017. We created a decedent cohort of beneficiaries aged 50 years or older at diagnosis with dementia or Parkinson disease. Specific low-value utilization outcomes were selected from the Choosing Wisely initiative, including cancer screening, peripheral artery stenting, and feeding tube pla...
Source: Clinical Colorectal Cancer - March 25, 2024 Category: Cancer & Oncology Authors: Margarethe E Goetz Cassie B Ford Melissa A Greiner Amy Clark Kim G Johnson Brystana G Kaufman Sneha Mantri Ying Xian Richard J O'Brien Emily C O'Brien Jay B Lusk Source Type: research
The cross talk of ubiquitination and chemotherapy tolerance in colorectal cancer
J Cancer Res Clin Oncol. 2024 Mar 23;150(3):154. doi: 10.1007/s00432-024-05659-9.ABSTRACTUbiquitination, a highly adaptable post-translational modification, plays a pivotal role in maintaining cellular protein homeostasis, encompassing cancer chemoresistance-associated proteins. Recent findings have indicated a potential correlation between perturbations in the ubiquitination process and the emergence of drug resistance in CRC cancer. Consequently, numerous studies have spurred the advancement of compounds specifically designed to target ubiquitinates, offering promising prospects for cancer therapy. In this review, we hig...
Source: Clinical Colorectal Cancer - March 24, 2024 Category: Cancer & Oncology Authors: Ze Rong Kaifeng Zheng Jun Chen Xiaofeng Jin Source Type: research
Curative criteria for endoscopic treatment of colorectal cancer
Best Pract Res Clin Gastroenterol. 2024 Feb;68:101883. doi: 10.1016/j.bpg.2024.101883. Epub 2024 Jan 25.ABSTRACTAs endoscopic treatment enables en bloc resection of T1 colorectal cancers, the risk of recurrence, often assimilated to the risk of lymph node metastases, must be assessed in order to offer patients an additional treatment if this risk is deemed significant. The curative criteria currently used by most guidelines are depth of invasion <1 mm, well or moderately differentiated tumour, absence of lympho-vascular invasion, absence of significant budding and tumour-free resection margins. However, these factors mu...
Source: Clinical Colorectal Cancer - March 24, 2024 Category: Cancer & Oncology Authors: Lucille Qu énéhervé Mathieu Pioche J érémie Jacques Source Type: research
Management of non-curative endoscopic resection of T1 colon cancer
Best Pract Res Clin Gastroenterol. 2024 Feb;68:101891. doi: 10.1016/j.bpg.2024.101891. Epub 2024 Feb 21.ABSTRACTEndoscopic resection techniques enable en-bloc resection of T1 colon cancers. A complete removal of T1 colon cancer can be considered curative when histologic examination of the specimens shows none of the high-risk factors for lymph nodes metastases. Criteria predicting lymph nodes metastases include deep submucosal invasion, poor differentiation, lymphovascular invasion, and high-grade tumor budding. In these cases, complete (R0), local endoscopic resection is considered sufficient as negligible risk of lymph n...
Source: Clinical Colorectal Cancer - March 24, 2024 Category: Cancer & Oncology Authors: Linn Bernklev Jens Aksel Nilsen Knut Magne Augestad Øyvind Holme Nastazja Dagny Pilonis Source Type: research
