Emerging and under-recognised patterns of colorectal carcinoma morphologies: a comprehensive review
J Clin Pathol. 2024 Mar 6:jcp-2023-208816. doi: 10.1136/jcp-2023-208816. Online ahead of print.ABSTRACTWhile the overwhelming majority of colorectal carcinomas (CRC) are diagnosed as adenocarcinoma not otherwise specified, there are numerous under-recognised morphologic patterns of CRC. These patterns are recognised by the WHO, appear in reporting manuals for the American Joint Committee of Cancer, and/or are listed on synoptic reports, while many other variants have either fallen out of favour or are emerging as future bona fide patterns. Herein, we discuss 13 variants: serrated adenocarcinoma, micropapillary adenocarcino...
Source: Clinical Colorectal Cancer - March 6, 2024 Category: Cancer & Oncology Authors: Yuho Ono Osman Yilmaz Source Type: research
The Contribution of Inherited Thrombophilia to Venous Thromboembolism in Cancer Patients
We describe 11 studies on the contribution of inherited thrombophilia to VTE in cancer patients in general and 10 on that contribution in specific types of cancer: 1 in colorectal cancer, 4 in breast cancer, 1 in gynecologic cancer and 4 in hematopoietic malignancies. All studies investigate the relation of factor V Leiden (FVL) to VTE, 13 that of the prothrombin G20210A mutation (PTG20210A) and 7 studies also investigate other inherited thrombophilias, such methylenetetrahydrofolate reductase gene mutations, although only 2 investigate the contribution of deficiencies of the natural anticoagulants. Studies are very hetero...
Source: Clinical Colorectal Cancer - March 5, 2024 Category: Cancer & Oncology Authors: Jos é Costa Ant ónio Araújo Source Type: research
The Contribution of Inherited Thrombophilia to Venous Thromboembolism in Cancer Patients
We describe 11 studies on the contribution of inherited thrombophilia to VTE in cancer patients in general and 10 on that contribution in specific types of cancer: 1 in colorectal cancer, 4 in breast cancer, 1 in gynecologic cancer and 4 in hematopoietic malignancies. All studies investigate the relation of factor V Leiden (FVL) to VTE, 13 that of the prothrombin G20210A mutation (PTG20210A) and 7 studies also investigate other inherited thrombophilias, such methylenetetrahydrofolate reductase gene mutations, although only 2 investigate the contribution of deficiencies of the natural anticoagulants. Studies are very hetero...
Source: Clinical Colorectal Cancer - March 5, 2024 Category: Cancer & Oncology Authors: Jos é Costa Ant ónio Araújo Source Type: research
Trastuzumab and Pertuzumab in Patients with Non-Breast/Gastroesophageal HER2-Amplified Tumors: Results from the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol J
CONCLUSIONS: HP was active in a selection of HER2-amplified tumors (non-breast/gastroesophageal) but did not meet the predefined efficacy benchmark. Additional strategies targeting HER2 and potential resistance pathways are warranted, especially in rare tumors.PMID:38433347 | DOI:10.1158/1078-0432.CCR-23-0633 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 4, 2024 Category: Cancer & Oncology Authors: Roisin M Connolly Victoria Wang David M Hyman Petros Grivas Edith P Mitchell John J Wright Elad Sharon Robert J Gray Lisa M McShane Larry V Rubinstein David R Patton P Mickey Williams Stanley R Hamilton Jue Wang Kari B Wisinski James V Tricoli Barbara A C Source Type: research
High KRT17 expression in tumour budding indicates immunologically 'hot' tumour budding and predicts good survival in patients with colorectal cancer
CONCLUSIONS: KRT17 can be employed as a new indicator for distinguishing different immunological TBs.PMID:38433762 | PMC:PMC10903186 | DOI:10.1002/cti2.1495 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 4, 2024 Category: Cancer & Oncology Authors: Wenfeng Liang Haiqing Jie Hao Xie Yebohao Zhou Wenxin Li Liang Huang Zhenxing Liang Huashan Liu Xiaobin Zheng Ziwei Zeng Liang Kang Source Type: research
The Efficacy of Real-Time Computer-Aided Detection of Colonic Neoplasia In Community Practice: A Pragmatic Randomized Controlled Trial
CONCLUSIONS: In a single-center pragmatic randomized controlled trial, real-time CADe modestly improved ADR and APC in average-detector community endoscopists. (ClinicalTrials.gov number, NCT05963724).PMID:38437999 | DOI:10.1016/j.cgh.2024.02.021 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 4, 2024 Category: Cancer & Oncology Authors: Nikhil R Thiruvengadam Pejman Solaimani Manish Shrestha Seth Buller Rachel Carson Breanna Reyes-Garcia Ronaldo D Gnass Bing Wang Natalie Albasha Paul Leonor Monica Saumoy Raul Coimbra Arnold Tabuenca Wichit Srikureja Steve Serrao Source Type: research
Trastuzumab and Pertuzumab in Patients with Non-Breast/Gastroesophageal HER2-Amplified Tumors: Results from the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol J
CONCLUSIONS: HP was active in a selection of HER2-amplified tumors (non-breast/gastroesophageal) but did not meet the predefined efficacy benchmark. Additional strategies targeting HER2 and potential resistance pathways are warranted, especially in rare tumors.PMID:38433347 | DOI:10.1158/1078-0432.CCR-23-0633 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 4, 2024 Category: Cancer & Oncology Authors: Roisin M Connolly Victoria Wang David M Hyman Petros Grivas Edith P Mitchell John J Wright Elad Sharon Robert J Gray Lisa M McShane Larry V Rubinstein David R Patton P Mickey Williams Stanley R Hamilton Jue Wang Kari B Wisinski James V Tricoli Barbara A C Source Type: research
High KRT17 expression in tumour budding indicates immunologically 'hot' tumour budding and predicts good survival in patients with colorectal cancer
CONCLUSIONS: KRT17 can be employed as a new indicator for distinguishing different immunological TBs.PMID:38433762 | PMC:PMC10903186 | DOI:10.1002/cti2.1495 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 4, 2024 Category: Cancer & Oncology Authors: Wenfeng Liang Haiqing Jie Hao Xie Yebohao Zhou Wenxin Li Liang Huang Zhenxing Liang Huashan Liu Xiaobin Zheng Ziwei Zeng Liang Kang Source Type: research
Evaluation of the risk factors for the failure of a single prophylactic dose of anticholinergic drugs for irinotecan-induced cholinergic symptoms
CONCLUSION: We determined that colorectal cancer, female sex, and prophylactic use of scopolamine butyl bromide were risk factors associated with the failure of a single prophylactic dose of anticholinergic drugs, and that multiple prophylactic doses for wearing-off can be a promising method.PMID:38431832 | DOI:10.5414/CP204531 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 3, 2024 Category: Cancer & Oncology Authors: Takuya Watanabe Yoshitaka Saito Yoh Takekuma Yasushi Shimizu Ichiro Kinoshita Yoshito Komatsu Mitsuru Sugawara Source Type: research
Dynamic prediction of advanced colorectal neoplasia in inflammatory bowel disease
CONCLUSION: The new prediction model showed good discrimination and calibration, however, generalizability results varied. Future research should focus on formal external validation and relate predicted aCRN risks to surveillance intervals prior to clinical application.PMID:38431223 | DOI:10.1016/j.cgh.2024.02.014 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 2, 2024 Category: Cancer & Oncology Authors: Anouk M Wijnands Bas B L Penning de Vries Maurice W M D Lutgens Zeinab Bakhshi Ibrahim Al Bakir Laurent Beaugerie Charles N Bernstein Ryan Chang-Ho Choi Nayantara Coelho-Prabhu Trevor A Graham Ailsa L Hart Joren R Ten Hove Steven H Itzkowitz Julien Kirchg Source Type: research
SBRT-SG-01: final results of a prospective multicenter study on stereotactic body radiotherapy for liver metastases
CONCLUSIONS: This prospective multicenter study confirms that liver SBRT is an effective alternative for the treatment of liver metastases, demonstrating high rates of local control and survival while maintaining a low toxicity profile.PMID:38431539 | DOI:10.1007/s12094-024-03403-w (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 2, 2024 Category: Cancer & Oncology Authors: Mar ía-Carmen Rubio Rodríguez Xin Chen-Zhao Ovidio Hernando Sonia Flamarique Pedro Fern ández-Letón Maider Campo Mercedes L ópez Maitane Rodr íguez Daniel Zucca Daniel Mart ínez Emilio S ánchez-Saugar Fernando Ma ñeru Juan Garc ía Ruiz-Zorrilla Source Type: research
The multivisceral landscape of colorectal cancer metastasis: implications for targeted therapies
J Clin Invest. 2024 Mar 1;134(5):e178331. doi: 10.1172/JCI178331.ABSTRACTColorectal cancer (CRC) is among the most common cancer types and the second deadliest malignancy for both sexes. Metastatic disease poses substantial therapeutic challenges, and peritoneal spread, in particular, reduces quality of life and has a dismal outcome. In this issue of the JCI, Berlin and authors have made considerable advancements in understanding the cellular and molecular composition of multivisceral CRC metastasis in a sophisticated murine orthotopic organoid model and in humans. The study provides unprecedented insights into the complex...
Source: Clinical Colorectal Cancer - March 1, 2024 Category: Cancer & Oncology Authors: Dominik Wolf Stefan Salcher Andreas Pircher Source Type: research
NETs unleashed: neutrophil extracellular traps boost chemotherapy against colorectal cancer
This study substantially advances our understanding of the multifaceted role of neutrophils and NETs in the outcome of anticancer treatment.PMID:38426501 | PMC:PMC10904039 | DOI:10.1172/JCI178344 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 1, 2024 Category: Cancer & Oncology Authors: Alexandra Mousset Jean Albrengues Source Type: research
Potent Tool: Helicobacter pylori Treatment to Reduce the Risk of Both Gastric and Colorectal Cancers
J Clin Oncol. 2024 Mar 1:JCO2400019. doi: 10.1200/JCO.24.00019. Online ahead of print.NO ABSTRACTPMID:38427926 | DOI:10.1200/JCO.24.00019 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 1, 2024 Category: Cancer & Oncology Authors: Julia Butt Meira Epplein Source Type: research
Impact of Helicobacter pylori Infection and Treatment on Colorectal Cancer in a Large, Nationwide Cohort
CONCLUSION: H. pylori positivity may be associated with small but statistically significant higher CRC incidence and mortality; untreated individuals, especially those with confirmed active infection, appear to be most at risk.PMID:38427927 | DOI:10.1200/JCO.23.00703 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 1, 2024 Category: Cancer & Oncology Authors: Shailja C Shah M Constanza Camargo Mark Lamm Ranier Bustamante Christianne L Roumie Otis Wilson Alese E Halvorson Robert Greevy Lin Liu Samir Gupta Joshua Demb Source Type: research
