Sequential RAS mutations evaluation in cell-free DNA of patients with tissue RAS wild-type metastatic colorectal cancer: the PERSEIDA (Cohort 2) study

CONCLUSIONS: The concordance rate between liquid and solid biopsies at baseline was very high, as previously reported, while our results suggest a considerable emergence of RAS mutations during disease progression. Thus, the dynamics of the genomic landscape in ctDNA may provide relevant information for the management of mCRC patients.PMID:38642257 | DOI:10.1007/s12094-024-03487-4

Source: Clinical Colorectal Cancer - April 20, 2024 Category: Cancer & Oncology Authors: Manuel Valladares-Ayerbes Maria Jos é Safont Encarnaci ón González Flores Pilar Garc ía-Alfonso Enrique Aranda Ana-Maria L ópez Muñoz Esther Falc ó Ferrer Lu ís Cirera Nogueras Nuria Rodr íguez-Salas Jorge Aparicio Marta Llanos Mu ñoz Paola Patr Source Type: research