TGFbeta signalling pathway impacts brain metastases profiles in locally advanced colorectal cancer
CONCLUSION: Our results suggest the TGFβ pathway as a crucial player in the development of brain metastases in primary CRC. In some types of colorectal cancer, downregulation of the TGFβ pathway might hinder primary colorectal cancer to metastasize to the nervous system. While the paradoxical functioning of the TGFβ pathway is still not fully understood, these shed light on yet another clinical implication of this complex pathway.PMID:38498101 | DOI:10.1007/s10585-024-10277-3 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 18, 2024 Category: Cancer & Oncology Authors: Sven Jacob Ilja Balonov Vindi Jurinovic Christian Heiliger Tengis Tschaidse J örg Kumbrink Thomas Kirchner Jens Werner Martin K Angele Marlies Michl Jens Neumann Source Type: research
Vaccination of Adults With Cancer: ASCO Guideline
J Clin Oncol. 2024 Mar 18:JCO2400032. doi: 10.1200/JCO.24.00032. Online ahead of print.ABSTRACTPURPOSE: To guide the vaccination of adults with solid tumors or hematologic malignancies.METHODS: A systematic literature review identified systematic reviews, randomized controlled trials (RCTs), and nonrandomized studies on the efficacy and safety of vaccines used by adults with cancer or their household contacts. This review builds on a 2013 guideline by the Infectious Disease Society of America. PubMed and the Cochrane Library were searched from January 1, 2013, to February 16, 2023. ASCO convened an Expert Panel to review t...
Source: Clinical Colorectal Cancer - March 18, 2024 Category: Cancer & Oncology Authors: Mini Kamboj Kari Bohlke Deana M Baptiste Kieron Dunleavy Abbey Fueger Lee Jones Amar H Kelkar Lisa Y Law Kristine B LeFebvre Per Ljungman Eric D Miller Larissa A Meyer Heather N Moore Heloisa P Soares Randy A Taplitz Edom S Woldetsadik Elise C Kohn Source Type: research
TGFbeta signalling pathway impacts brain metastases profiles in locally advanced colorectal cancer
CONCLUSION: Our results suggest the TGFβ pathway as a crucial player in the development of brain metastases in primary CRC. In some types of colorectal cancer, downregulation of the TGFβ pathway might hinder primary colorectal cancer to metastasize to the nervous system. While the paradoxical functioning of the TGFβ pathway is still not fully understood, these shed light on yet another clinical implication of this complex pathway.PMID:38498101 | DOI:10.1007/s10585-024-10277-3 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 18, 2024 Category: Cancer & Oncology Authors: Sven Jacob Ilja Balonov Vindi Jurinovic Christian Heiliger Tengis Tschaidse J örg Kumbrink Thomas Kirchner Jens Werner Martin K Angele Marlies Michl Jens Neumann Source Type: research
Vaccination of Adults With Cancer: ASCO Guideline
J Clin Oncol. 2024 Mar 18:JCO2400032. doi: 10.1200/JCO.24.00032. Online ahead of print.ABSTRACTPURPOSE: To guide the vaccination of adults with solid tumors or hematologic malignancies.METHODS: A systematic literature review identified systematic reviews, randomized controlled trials (RCTs), and nonrandomized studies on the efficacy and safety of vaccines used by adults with cancer or their household contacts. This review builds on a 2013 guideline by the Infectious Disease Society of America. PubMed and the Cochrane Library were searched from January 1, 2013, to February 16, 2023. ASCO convened an Expert Panel to review t...
Source: Clinical Colorectal Cancer - March 18, 2024 Category: Cancer & Oncology Authors: Mini Kamboj Kari Bohlke Deana M Baptiste Kieron Dunleavy Abbey Fueger Lee Jones Amar H Kelkar Lisa Y Law Kristine B LeFebvre Per Ljungman Eric D Miller Larissa A Meyer Heather N Moore Heloisa P Soares Randy A Taplitz Edom S Woldetsadik Elise C Kohn Source Type: research
Use of tryptic peptide MALDI mass spectrometry imaging to identify the spatial proteomic landscape of colorectal cancer liver metastases
This study utilised matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI) in combination with liquid chromatography-tandem mass spectrometry (LC-MS/MS) to spatially map the CRLM tumour proteome. CRLM tissue microarrays (TMAs) of 84 patients were analysed using tryptic peptide MALDI-MSI to spatially monitor peptide abundances across CRLM tissues. Abundance of peptides was compared between tumour vs stroma, male vs female and across three groups of patients based on overall survival (0-3 years, 4-6 years, and 7+ years). Peptides were then characterised and matched using LC-MS/MS. A total of 471 po...
Source: Clinical Colorectal Cancer - March 16, 2024 Category: Cancer & Oncology Authors: Celine Man Ying Li Matthew T Briggs Yea-Rin Lee Teresa Tin Clifford Young John Pierides Gurjeet Kaur Paul Drew Guy J Maddern Peter Hoffmann Manuela Klingler-Hoffmann Kevin Fenix Source Type: research
Use of tryptic peptide MALDI mass spectrometry imaging to identify the spatial proteomic landscape of colorectal cancer liver metastases
This study utilised matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI) in combination with liquid chromatography-tandem mass spectrometry (LC-MS/MS) to spatially map the CRLM tumour proteome. CRLM tissue microarrays (TMAs) of 84 patients were analysed using tryptic peptide MALDI-MSI to spatially monitor peptide abundances across CRLM tissues. Abundance of peptides was compared between tumour vs stroma, male vs female and across three groups of patients based on overall survival (0-3 years, 4-6 years, and 7+ years). Peptides were then characterised and matched using LC-MS/MS. A total of 471 po...
Source: Clinical Colorectal Cancer - March 16, 2024 Category: Cancer & Oncology Authors: Celine Man Ying Li Matthew T Briggs Yea-Rin Lee Teresa Tin Clifford Young John Pierides Gurjeet Kaur Paul Drew Guy J Maddern Peter Hoffmann Manuela Klingler-Hoffmann Kevin Fenix Source Type: research
The cholesterol biosynthesis enzyme FAXDC2 couples Wnt/ β-catenin to RTK/MAPK signaling
J Clin Invest. 2024 Jan 23;134(6):e171222. doi: 10.1172/JCI171222.ABSTRACTWnts, cholesterol, and MAPK signaling are essential for development and adult homeostasis. Here, we report that fatty acid hydroxylase domain containing 2 (FAXDC2), a previously uncharacterized enzyme, functions as a methyl sterol oxidase catalyzing C4 demethylation in the Kandutsch-Russell branch of the cholesterol biosynthesis pathway. FAXDC2, a paralog of MSMO1, regulated the abundance of the specific C4-methyl sterols lophenol and dihydro-T-MAS. Highlighting its clinical relevance, FAXDC2 was repressed in Wnt/β-catenin-high cancer xenografts, in...
Source: Clinical Colorectal Cancer - March 15, 2024 Category: Cancer & Oncology Authors: Babita Madan Shawn R Wadia Siddhi Patnaik Nathan Harmston Emile Tan Iain Bee Huat Tan W David Nes Enrico Petretto David M Virshup Source Type: research
Single-cell sequencing reveals alterations in the peripheral blood mononuclear cell landscape and monocyte status during colorectal adenocarcinoma formation
Clin Transl Med. 2024 Mar;14(3):e1609. doi: 10.1002/ctm2.1609.NO ABSTRACTPMID:38488463 | PMC:PMC10941536 | DOI:10.1002/ctm2.1609 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 15, 2024 Category: Cancer & Oncology Authors: Jiasheng Xu Yeting Hu Jie Zhao Xiangxing Kong Sijian Xia Siqi Dai Lei Ding Tongtong Bu Yue Cao Manjiao Liu Linlin Yan Qian Xiao Hao Guo Ying Yuan Dong Xu Kefeng Ding Source Type: research
Racial Disparities in Receipt of Guideline-Concordant Care for Early-Onset Colorectal Cancer-We Must Do Better
J Clin Oncol. 2024 Mar 15:JCO2302186. doi: 10.1200/JCO.23.02186. Online ahead of print.NO ABSTRACTPMID:38489553 | DOI:10.1200/JCO.23.02186 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 15, 2024 Category: Cancer & Oncology Authors: Winta T Mehtsun Samir Gupta Source Type: research
Risk of Cancer in Patients with Diverticular Disease: A Population-based Cohort Study
CONCLUSIONS: Our findings show an increased long-term relative risk of cancer following a diagnosis of DD. These findings are likely due to prevalence of numerous risk factors in DD patients that confer an increased risk of cancer. The decreased relative risk of colorectal cancer might be explained by an increased likelihood of DD patients undergoing colonoscopy with polypectomy.PMID:38490316 | DOI:10.1016/j.cgh.2024.02.024 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 15, 2024 Category: Cancer & Oncology Authors: Frederikke S Troelsen D óra K Farkas Rune Erichsen Lisa L Strate John A Baron Henrik T S ørensen Source Type: research
The cholesterol biosynthesis enzyme FAXDC2 couples Wnt/ β-catenin to RTK/MAPK signaling
J Clin Invest. 2024 Jan 23;134(6):e171222. doi: 10.1172/JCI171222.ABSTRACTWnts, cholesterol, and MAPK signaling are essential for development and adult homeostasis. Here, we report that fatty acid hydroxylase domain containing 2 (FAXDC2), a previously uncharacterized enzyme, functions as a methyl sterol oxidase catalyzing C4 demethylation in the Kandutsch-Russell branch of the cholesterol biosynthesis pathway. FAXDC2, a paralog of MSMO1, regulated the abundance of the specific C4-methyl sterols lophenol and dihydro-T-MAS. Highlighting its clinical relevance, FAXDC2 was repressed in Wnt/β-catenin-high cancer xenografts, in...
Source: Clinical Colorectal Cancer - March 15, 2024 Category: Cancer & Oncology Authors: Babita Madan Shawn R Wadia Siddhi Patnaik Nathan Harmston Emile Tan Iain Bee Huat Tan W David Nes Enrico Petretto David M Virshup Source Type: research
Single-cell sequencing reveals alterations in the peripheral blood mononuclear cell landscape and monocyte status during colorectal adenocarcinoma formation
Clin Transl Med. 2024 Mar;14(3):e1609. doi: 10.1002/ctm2.1609.NO ABSTRACTPMID:38488463 | DOI:10.1002/ctm2.1609 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 15, 2024 Category: Cancer & Oncology Authors: Jiasheng Xu Yeting Hu Jie Zhao Xiangxing Kong Sijian Xia Siqi Dai Lei Ding Tongtong Bu Yue Cao Manjiao Liu Linlin Yan Qian Xiao Hao Guo Ying Yuan Dong Xu Kefeng Ding Source Type: research
Racial Disparities in Receipt of Guideline-Concordant Care for Early-Onset Colorectal Cancer-We Must Do Better
J Clin Oncol. 2024 Mar 15:JCO2302186. doi: 10.1200/JCO.23.02186. Online ahead of print.NO ABSTRACTPMID:38489553 | DOI:10.1200/JCO.23.02186 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 15, 2024 Category: Cancer & Oncology Authors: Winta T Mehtsun Samir Gupta Source Type: research
Risk of Cancer in Patients with Diverticular Disease: A Population-based Cohort Study
CONCLUSIONS: Our findings show an increased long-term relative risk of cancer following a diagnosis of DD. These findings are likely due to prevalence of numerous risk factors in DD patients that confer an increased risk of cancer. The decreased relative risk of colorectal cancer might be explained by an increased likelihood of DD patients undergoing colonoscopy with polypectomy.PMID:38490316 | DOI:10.1016/j.cgh.2024.02.024 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 15, 2024 Category: Cancer & Oncology Authors: Frederikke S Troelsen D óra K Farkas Rune Erichsen Lisa L Strate John A Baron Henrik T S ørensen Source Type: research
Type 2 diabetes mellitus and post-colonoscopy colorectal cancer: clinical and molecular characteristics and survival
CONCLUSION: The increased prevalence of proximally located PCCRCs and the poorer survival may suggest overlooked colorectal lesions as a predominant explanation for T2D-related PCCRC, although altered tumor progression cannot be ruled out.PMID:38483686 | DOI:10.1007/s10552-024-01861-9 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 14, 2024 Category: Cancer & Oncology Authors: Mette L Boysen Frederikke S Troelsen Henrik T S ørensen Rune Erichsen Source Type: research
