TGFbeta signalling pathway impacts brain metastases profiles in locally advanced colorectal cancer

CONCLUSION: Our results suggest the TGFβ pathway as a crucial player in the development of brain metastases in primary CRC. In some types of colorectal cancer, downregulation of the TGFβ pathway might hinder primary colorectal cancer to metastasize to the nervous system. While the paradoxical functioning of the TGFβ pathway is still not fully understood, these shed light on yet another clinical implication of this complex pathway.PMID:38498101 | DOI:10.1007/s10585-024-10277-3

Source: Clinical Colorectal Cancer - March 18, 2024 Category: Cancer & Oncology Authors: Sven Jacob Ilja Balonov Vindi Jurinovic Christian Heiliger Tengis Tschaidse J örg Kumbrink Thomas Kirchner Jens Werner Martin K Angele Marlies Michl Jens Neumann Source Type: research