Roche announces positive Phase III results for inavolisib combination in people with advanced hormone receptor-positive, HER2-negative breast cancer with a PIK3CA mutation
Phase III (INAVO120) results show that inavolisib in combination with palbociclib and fulvestrant significantly improved progression-free survival in the first-line settingPIK3CA mutations, found in approximately 40% of HR-positive breast cancers, are linked to tumour growth, disease progression, and treatment resistance1,2Data will be shared with health authorities and presented at an upcoming medical meetingBasel, 5 December 2023 - Roche (SIX: RO, ROG; OTCQX: RHHBY) announced today positive results from the Phase III INAVO120 study of the investigational therapy, inavolisib, in combination with palbociclib (Ibrance ®) a...
Source: Roche Media News - December 5, 2023 Category: Pharmaceuticals Source Type: news
AI model aids in ultrasound rotator cuff exams
An AI assistance system can aid novice sonographers in assessing the rotator cuff, a study published December 1 in Ultrasound in Medicine & Biology found.
Researchers led by Rui Tang from Peking University Third Hospital in Beijing, China, found that their AI system can accurately identify standard planes and perform automatic tissue segmentation.
“Remarkably, the system demonstrated superior performance compared with similar studies for both functions,” Tang and colleagues wrote.
While ultrasound is a go-to method for assessing shoulder joint diseases, it is a user-dependent modality. Novice ultrasonographers may s...
Source: AuntMinnie.com Headlines - December 5, 2023 Category: Radiology Authors: Amerigo Allegretto Tags: Subspecialties Ultrasound Musculoskeletal Radiology Source Type: news
Roche announces positive Phase III results for inavolisib combination in people with advanced hormone receptor-positive, HER2-negative breast cancer with a PIK3CA mutation
Phase III (INAVO120) results show that inavolisib in combination with palbociclib and fulvestrant significantly improved progression-free survival in the first-line settingPIK3CA mutations, found in approximately 40% of HR-positive breast cancers, are linked to tumour growth, disease progression, and treatment resistance1,2Data will be shared with health authorities and presented at an upcoming medical meetingBasel, 5 December 2023 - Roche (SIX: RO, ROG; OTCQX: RHHBY) announced today positive results from the Phase III INAVO120 study of the investigational therapy, inavolisib, in combination with palbociclib (Ibrance ®) a...
Source: Roche Investor Update - December 5, 2023 Category: Pharmaceuticals Source Type: news
A Journey With Metabolism, Parasites, and Cancer
Piet Borst led stellar work on cell organelles, trypanosomes, and cancer drug resistance during the golden age of biology. (Source: The Scientist)
Source: The Scientist - December 5, 2023 Category: Science Tags: Profile Magazine Issue Source Type: news
Roche enters into a definitive merger agreement to acquire Carmot Therapeutics, including three clinical stage assets with best-in-class potential in obesity and diabetes
Carmot Therapeutics ’s R&D portfolio of clinical stage incretins has great potential to treat obesity, diabetes and potentially other diseases both as standalone medicines and in combination with Roche ’s in-house assetsLead asset CT-388 is a Phase-2 ready dual GLP-1/GIP agonist with best-in-class potential for the treatment of obesity and its comorbiditiesUnder the terms of the agreement, Roche will pay a purchase price of USD 2.7 billion upfront and additional milestone payments of up to USD 400 millionBasel, 4 December 2023 - Roche (SIX: RO, ROG; OTCQX: RHHBY) announced today the entry into a definitive merger a...
Source: Roche Investor Update - December 4, 2023 Category: Pharmaceuticals Source Type: news
Roche enters into a definitive merger agreement to acquire Carmot Therapeutics, including three clinical stage assets with best-in-class potential in obesity and diabetes
Carmot Therapeutics ’s R&D portfolio of clinical stage incretins has great potential to treat obesity, diabetes and potentially other diseases both as standalone medicines and in combination with Roche ’s in-house assetsLead asset CT-388 is a Phase-2 ready dual GLP-1/GIP agonist with best-in-class potential for the treatment of obesity and its comorbiditiesUnder the terms of the agreement, Roche will pay a purchase price of USD 2.7 billion upfront and additional milestone payments of up to USD 400 millionBasel, 4 December 2023 - Roche (SIX: RO, ROG; OTCQX: RHHBY) announced today the entry into a definitive merger a...
Source: Roche Media News - December 4, 2023 Category: Pharmaceuticals Source Type: news
Serendipity, Happenstance, and Luck: The Making of a Molecular Tool
The common fluorescent marker GFP traveled a long road to take its popular place in molecular biology today. (Source: The Scientist)
Source: The Scientist - December 4, 2023 Category: Science Tags: Foundations Magazine Issue Source Type: news
Vincent Marks obituary
Biochemist who transformed the treatment of diabetes and was an expert witness in two high-profile murder trialsVincent Marks, who has died aged 93, was a world expert in insulin and hypoglycaemia (low blood sugar). In 1985, his expert opinion helped to acquitClaus von B ülow of attempted murder, in a case that was dramatised in the film Reversal of Fortune (1990).On 21 December 1980, the American heiress Sunny von B ülow was discovered comatose in her bathroom, and she remained in a persistent vegetative state untilher death in 2008. Her husband Claus, a Danish-born lawyer, was tried and found guilty of injecting her wi...
Source: Guardian Unlimited Science - December 3, 2023 Category: Science Authors: Penny Warren Tags: Diabetes Health Biochemistry and molecular biology Medical research Medicine Society Science Source Type: news
Health and zombie cells in aging
With age, cells can experience senescence, a state where they stop growing but continue releasing inflammatory and tissue-degrading molecules. When a person is young, the immune system responds and eliminates senescent cells, often referred to as zombie cells. However, zombie cells linger and contribute to various age-related health problems and diseases. Mayo Clinic researchers, in two studies, shed light on the biology of aging cells. In a study published in Aging Cell, Mayo Clinic researchers analyzed zombie… (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - December 1, 2023 Category: Databases & Libraries Source Type: news
Tiny ‘anthrobots’ built from human cells could help heal the body
In the medicine of the future, molecular physicians built from a patient’s own cells might ferret out cancer, repair injured tissue, and even remove plaque from blood vessels. Researchers have now taken a step toward that vision: They’ve coaxed tracheal cells to form coordinated groups called organoids that can propel themselves with tiny appendages. When added to wounded neurons in the lab,
these “anthrobots” helped neurons repair themselves
.
The work, reported today in
Advanced Science
, “is amazing, and groundbreaking,” says Xi “Charlie” Ren, a tissue engineer at Carnegie Mello...
Source: ScienceNOW - November 30, 2023 Category: Science Source Type: news
Scientists thought they understood maize ’s origins. They were missing something big
Maize is one of the world’s most important crops, but its origins have long bedeviled scientists. It took more than a century for scientists to settle on the idea that it was
domesticated about 9000 years ago
in the lowlands of Mexico from a wild grass: a subspecies of teosinte called
parviglumis
. But now, a team of geneticists has complicated that history, reporting today in
Science
that
maize as we know it has a second wild ancestor
. Between 15% and 25% of the genes in all existing maize varieties come not from
parviglumis
, but from a highland subspecies of teosinte ...
Source: ScienceNOW - November 30, 2023 Category: Science Source Type: news
News at a glance: Lower pay for disabled Ph.D.s, more U.K. genomes, and quitting antismoking rules
LEADERSHIP
Argentina’s president targets science
The election last week of libertarian Javier Milei as Argentina’s next president has many of the nation’s scientists fearing the future. Milei, who won 55.7% of the vote, has
vowed to close or dramatically restructure the National Scientific and Technical Research Council
(CONICET), Argentina’s main science funding agency, and its health and environment ministries. He views climate change as a “socialist hoax.” Milei has called CONICET, which employs nearly 12,000 researchers and ranks as one of South America’s top government s...
Source: ScienceNOW - November 30, 2023 Category: Science Source Type: news
This Startup Just Raised $19 Million To Bring An Industrial Revolution To Biology
London-based Mytos has developed a way to automate aspects of biological research that are still tediously done by hand. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - November 30, 2023 Category: Pharmaceuticals Authors: Alex Knapp, Forbes Staff Tags: Science /science Innovation /innovation Healthcare /healthcare Leadership /leadership Under 30 /under30 Venture Capital /venture-capital Editors' Pick editors-pick technology alexknappblog premium Source Type: news
UK Biobank and the masses of medical data that became key to genetic research
The resource, which is on the move to Manchester, now ranks as the world ’s most important health databaseThe origins of the UK Biobank can be traced back to a pilot study in a building in Stockport bordered by the Cheadle Heath police station on one side and the local recreation ground on the other. It was the early 2000s and scientists had realised the potential for genomics and big data to transform health research.With diabetes, cancer, dementia and other ailments on the rise, scientists pushed for a database devoted to genetics, health and lifestyle to help them tease apart who was most at risk and how diseases coul...
Source: Guardian Unlimited Science - November 30, 2023 Category: Science Authors: Ian Sample Science editor Tags: Medical research Genetics Biology Science UK news Stockport Manchester Greater Manchester Source Type: news
The Evolutionary Origins of Psychedelics
Humans rely on a bevy of strange natural chemicals to liven up our food and drink, to endure pain, and to change our perspective. We use caffeine from coffee, tea, and yerba mate to stimulate our bodies and minds, capsaicin from red pepper flakes or isothiocyanates in horseradish or wasabi to enliven our food with spice, and codeine or morphine to endure the pain of injuries and surgeries.
Lately, though, some have also turned to psychedelics like psilocybin to change their perspectives. In fact, researchers are beginning to test if they could serve as new treatments for mental health disorders.
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Source: TIME: Health - November 29, 2023 Category: Consumer Health News Authors: Noah Whiteman Tags: Uncategorized freelance Source Type: news
