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Response to Comment on "Selective anaerobic oxidation of methane enables direct synthesis of methanol"
Periana argues that the stepwise reaction of methane with water is thermodynamically unfavorable and therefore impractical. We reply by presenting an in-depth thermodynamic analysis of each step in the process and show that the surface concentrations of the reactants and products as well as the stabilizing effect of additional water molecules, as discussed in the original paper, fully support the feasibility of the proposed reaction. (Source: ScienceNOW)
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Sushkevich, V. L., Palagin, D., Ranocchiari, M., van Bokhoven, J. A. Tags: Chemistry, Online Only t-comment Source Type: news

Comment on "Selective anaerobic oxidation of methane enables direct synthesis of methanol"
Sushkevich et al. (Reports, 5 May 2017, p. 523) report on the use of water to oxidize methane to methanol. This seems problematic because the reaction of CH4 and water to generate methanol and H2 is highly unfavorable at any temperature (G of reaction +28 kcal/mol at 200°C, equilibrium constant K 10–13). Consequently, even if the reaction is separated into two steps, it seems inconceivable to carry out such a net reaction in a practical manner. (Source: ScienceNOW)
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Periana, R. A. Tags: Chemistry, Online Only t-comment Source Type: news

Spaceborne detection of localized carbon dioxide sources
Spaceborne measurements by NASA’s Orbiting Carbon Observatory-2 (OCO-2) at the kilometer scale reveal distinct structures of atmospheric carbon dioxide (CO2) caused by known anthropogenic and natural point sources. OCO-2 transects across the Los Angeles megacity (USA) show that anthropogenic CO2 enhancements peak over the urban core and decrease through suburban areas to rural background values more than ~100 kilometers away, varying seasonally from ~4.4 to 6.1 parts per million. A transect passing directly downwind of the persistent isolated natural CO2 plume from Yasur volcano (Vanuatu) shows a narrow filament of e...
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Schwandner, F. M., Gunson, M. R., Miller, C. E., Carn, S. A., Eldering, A., Krings, T., Verhulst, K. R., Schimel, D. S., Nguyen, H. M., Crisp, D., ODell, C. W., Osterman, G. B., Iraci, L. T., Podolske, J. R. Tags: special/r-articles Source Type: news

Influence of El Nino on atmospheric CO2 over the tropical Pacific Ocean: Findings from NASAs OCO-2 mission
Spaceborne observations of carbon dioxide (CO2) from the Orbiting Carbon Observatory-2 are used to characterize the response of tropical atmospheric CO2 concentrations to the strong El Niño event of 2015–2016. Although correlations between the growth rate of atmospheric CO2 concentrations and the El Niño–Southern Oscillation are well known, the magnitude of the correlation and the timing of the responses of oceanic and terrestrial carbon cycle remain poorly constrained in space and time. We used space-based CO2 observations to confirm that the tropical Pacific Ocean does play an early and importan...
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Chatterjee, A., Gierach, M. M., Sutton, A. J., Feely, R. A., Crisp, D., Eldering, A., Gunson, M. R., ODell, C. W., Stephens, B. B., Schimel, D. S. Tags: Atmospheric Science, Online Only special/r-articles Source Type: news

OCO-2 advances photosynthesis observation from space via solar-induced chlorophyll fluorescence
Quantifying gross primary production (GPP) remains a major challenge in global carbon cycle research. Spaceborne monitoring of solar-induced chlorophyll fluorescence (SIF), an integrative photosynthetic signal of molecular origin, can assist in terrestrial GPP monitoring. However, the extent to which SIF tracks spatiotemporal variations in GPP remains unresolved. Orbiting Carbon Observatory-2 (OCO-2)’s SIF data acquisition and fine spatial resolution permit direct validation against ground and airborne observations. Empirical orthogonal function analysis shows consistent spatiotemporal correspondence between OCO-2 SI...
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Sun, Y., Frankenberg, C., Wood, J. D., Schimel, D. S., Jung, M., Guanter, L., Drewry, D. T., Verma, M., Porcar-Castell, A., Griffis, T. J., Gu, L., Magney, T. S., Köhler, P., Evans, B., Yuen, K. Tags: Ecology, Geochemistry, Geophysics, Online Only special/r-articles Source Type: news

The Orbiting Carbon Observatory-2 early science investigations of regional carbon dioxide fluxes
NASA’s Orbiting Carbon Observatory-2 (OCO-2) mission was motivated by the need to diagnose how the increasing concentration of atmospheric carbon dioxide (CO2) is altering the productivity of the biosphere and the uptake of CO2 by the oceans. Launched on 2 July 2014, OCO-2 provides retrievals of the column-averaged CO2 dry-air mole fraction (XCO2) as well as the fluorescence from chlorophyll in terrestrial plants. The seasonal pattern of uptake by the terrestrial biosphere is recorded in fluorescence and the drawdown of XCO2 during summer. Launched just before one of the most intense El Niños of the past centu...
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Eldering, A., Wennberg, P. O., Crisp, D., Schimel, D. S., Gunson, M. R., Chatterjee, A., Liu, J., Schwandner, F. M., Sun, Y., ODell, C. W., Frankenberg, C., Taylor, T., Fisher, B., Osterman, G. B., Wunch, D., Hakkarainen, J., Tamminen, J., Weir, B. Tags: Atmospheric Science, Online Only special/r-articles Source Type: news

Contrasting carbon cycle responses of the tropical continents to the 2015-2016 El Nino
The 2015–2016 El Niño led to historically high temperatures and low precipitation over the tropics, while the growth rate of atmospheric carbon dioxide (CO2) was the largest on record. Here we quantify the response of tropical net biosphere exchange, gross primary production, biomass burning, and respiration to these climate anomalies by assimilating column CO2, solar-induced chlorophyll fluorescence, and carbon monoxide observations from multiple satellites. Relative to the 2011 La Niña, the pantropical biosphere released 2.5 ± 0.34 gigatons more carbon into the atmosphere in 2015, consisting of...
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Liu, J., Bowman, K. W., Schimel, D. S., Parazoo, N. C., Jiang, Z., Lee, M., Bloom, A. A., Wunch, D., Frankenberg, C., Sun, Y., ODell, C. W., Gurney, K. R., Menemenlis, D., Gierach, M., Crisp, D., Eldering, A. Tags: Geochemistry, Geophysics, Online Only special/r-articles Source Type: news

The microanatomic segregation of selection by apoptosis in the germinal center
B cells undergo rapid cell division and affinity maturation in anatomically distinct sites in lymphoid organs called germinal centers (GCs). Homeostasis is maintained in part by B cell apoptosis. However, the precise contribution of apoptosis to GC biology and selection is not well defined. We developed apoptosis-indicator mice and used them to visualize, purify, and characterize dying GC B cells. Apoptosis is prevalent in the GC, with up to half of all GC B cells dying every 6 hours. Moreover, programmed cell death is differentially regulated in the light zone and the dark zone: Light-zone B cells die by default if they a...
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Mayer, C. T., Gazumyan, A., Kara, E. E., Gitlin, A. D., Golijanin, J., Viant, C., Pai, J., Oliveira, T. Y., Wang, Q., Escolano, A., Medina-Ramirez, M., Sanders, R. W., Nussenzweig, M. C. Tags: Immunology, Online Only r-articles Source Type: news

Cover stories: Making the Orbiting Carbon Observatory-2 cover
(Source: ScienceNOW)
Source: ScienceNOW - October 12, 2017 Category: Science Tags: multimedia Source Type: news

I am a United Academic Worker
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Source: ScienceNOW - October 12, 2017 Category: Science Authors: Weitzner, B. D. Tags: Working Life Source Type: news

AAAS 2018 Annual Meeting Program
(Source: ScienceNOW)
Source: ScienceNOW - October 12, 2017 Category: Science Tags: a-affairs Source Type: news

Sponsored Collection | Accelerating the path from structure to function through integrated structural biology solutions
(Source: ScienceNOW)
Source: ScienceNOW - October 12, 2017 Category: Science Tags: Botany, Cell Biology, Medicine, Diseases, Neuroscience, Pharmacology, Toxicology opms-sups Source Type: news

New Products
(Source: ScienceNOW)
Source: ScienceNOW - October 12, 2017 Category: Science Tags: products Source Type: news

Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water
A substantial fraction of the proteome is intrinsically disordered, and even well-folded proteins adopt non-native geometries during synthesis, folding, transport, and turnover. Characterization of intrinsically disordered proteins (IDPs) is challenging, in part because of a lack of accurate physical models and the difficulty of interpreting experimental results. We have developed a general method to extract the dimensions and solvent quality (self-interactions) of IDPs from a single small-angle x-ray scattering measurement. We applied this procedure to a variety of IDPs and found that even IDPs with low net charge and hig...
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Riback, J. A., Bowman, M. A., Zmyslowski, A. M., Knoverek, C. R., Jumper, J. M., Hinshaw, J. R., Kaye, E. B., Freed, K. F., Clark, P. L., Sosnick, T. R. Tags: Biochemistry reports Source Type: news

Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer
Mutational processes underlie cancer initiation and progression. Signatures of these processes in cancer genomes may explain cancer etiology and could hold diagnostic and prognostic value. We developed a strategy that can be used to explore the origin of cancer-associated mutational signatures. We used CRISPR-Cas9 technology to delete key DNA repair genes in human colon organoids, followed by delayed subcloning and whole-genome sequencing. We found that mutation accumulation in organoids deficient in the mismatch repair gene MLH1 is driven by replication errors and accurately models the mutation profiles observed in mismat...
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Drost, J., van Boxtel, R., Blokzijl, F., Mizutani, T., Sasaki, N., Sasselli, V., de Ligt, J., Behjati, S., Grolleman, J. E., van Wezel, T., Nik-Zainal, S., Kuiper, R. P., Cuppen, E., Clevers, H. Tags: Genetics, Medicine, Diseases reports Source Type: news

Tropical forests are a net carbon source based on aboveground measurements of gain and loss
The carbon balance of tropical ecosystems remains uncertain, with top-down atmospheric studies suggesting an overall sink and bottom-up ecological approaches indicating a modest net source. Here we use 12 years (2003 to 2014) of MODIS pantropical satellite data to quantify net annual changes in the aboveground carbon density of tropical woody live vegetation, providing direct, measurement-based evidence that the world’s tropical forests are a net carbon source of 425.2 ± 92.0 teragrams of carbon per year (Tg C year–1). This net release of carbon consists of losses of 861.7 ± 80.2 Tg C year–1...
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Baccini, A., Walker, W., Carvalho, L., Farina, M., Sulla-Menashe, D., Houghton, R. A. Tags: Geochemistry, Geophysics reports Source Type: news

Mapping spiral structure on the far side of the Milky Way
We report a direct trigonometric parallax distance of 20.4–2.2+2.8 kiloparsec obtained with the Very Long Baseline Array to a water maser source in a region of active star formation. These measurements allow us to shed light on Galactic spiral structure by locating the Scutum-Centaurus spiral arm as it passes through the far side of the Milky Way and to validate a kinematic method for determining distances in this region on the basis of transverse motions. (Source: ScienceNOW)
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Sanna, A., Reid, M. J., Dame, T. M., Menten, K. M., Brunthaler, A. Tags: Astronomy reports Source Type: news

Aqueous Au-Pd colloids catalyze selective CH4 oxidation to CH3OH with O2 under mild conditions
The selective oxidation of methane, the primary component of natural gas, remains an important challenge in catalysis. We used colloidal gold-palladium nanoparticles, rather than the same nanoparticles supported on titanium oxide, to oxidize methane to methanol with high selectivity (92%) in aqueous solution at mild temperatures. Then, using isotopically labeled oxygen (O2) as an oxidant in the presence of hydrogen peroxide (H2O2), we demonstrated that the resulting methanol incorporated a substantial fraction (70%) of gas-phase O2. More oxygenated products were formed than the amount of H2O2 consumed, suggesting that the ...
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Agarwal, N., Freakley, S. J., McVicker, R. U., Althahban, S. M., Dimitratos, N., He, Q., Morgan, D. J., Jenkins, R. L., Willock, D. J., Taylor, S. H., Kiely, C. J., Hutchings, G. J. Tags: Chemistry reports Source Type: news

Scalable synthesis of bryostatin 1 and analogs, adjuvant leads against latent HIV
Bryostatin 1 is an exceedingly scarce marine-derived natural product that is in clinical development directed at HIV/AIDS eradication, cancer immunotherapy, and the treatment of Alzheimer’s disease. Despite this unique portfolio of indications, its availability has been limited and variable, thus impeding research and clinical studies. Here, we report a total synthesis of bryostatin 1 that proceeds in 29 total steps (19 in the longest linear sequence,>80% average yield per step), collectively produces grams of material, and can be scaled to meet clinical needs (~20 grams per year). This practical solution to the b...
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Wender, P. A., Hardman, C. T., Ho, S., Jeffreys, M. S., Maclaren, J. K., Quiroz, R. V., Ryckbosch, S. M., Shimizu, A. J., Sloane, J. L., Stevens, M. C. Tags: Chemistry, Medicine, Diseases reports Source Type: news

Anti-Markovnikov alkene oxidation by metal-oxo-mediated enzyme catalysis
Catalytic anti-Markovnikov oxidation of alkene feedstocks could simplify synthetic routes to many important molecules and solve a long-standing challenge in chemistry. Here we report the engineering of a cytochrome P450 enzyme by directed evolution to catalyze metal-oxo–mediated anti-Markovnikov oxidation of styrenes with high efficiency. The enzyme uses dioxygen as the terminal oxidant and achieves selectivity for anti-Markovnikov oxidation over the kinetically favored alkene epoxidation by trapping high-energy intermediates and catalyzing an oxo transfer, including an enantioselective 1,2-hydride migration. The ant...
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Hammer, S. C., Kubik, G., Watkins, E., Huang, S., Minges, H., Arnold, F. H. Tags: Biochemistry, Chemistry reports Source Type: news

Stretchable surfaces with programmable 3D texture morphing for synthetic camouflaging skins
Technologies that use stretchable materials are increasingly important, yet we are unable to control how they stretch with much more sophistication than inflating balloons. Nature, however, demonstrates remarkable control of stretchable surfaces; for example, cephalopods can project hierarchical structures from their skin in milliseconds for a wide range of textural camouflage. Inspired by cephalopod muscular morphology, we developed synthetic tissue groupings that allowed programmable transformation of two-dimensional (2D) stretchable surfaces into target 3D shapes. The synthetic tissue groupings consisted of elastomeric ...
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Pikul, J. H., Li, S., Bai, H., Hanlon, R. T., Cohen, I., Shepherd, R. F. Tags: Physics, Applied reports Source Type: news

Imaging the halogen bond in self-assembled halogenbenzenes on silver
Halogens are among the most electronegative elements, and the variations in size and polarizability of halogens require different descriptions of the intermolecular bonds they form. Here we use the inelastic tunneling probe (itProbe) to acquire real-space imaging of intermolecular-bonding structures in the two-dimensional self-assembly of halogenbenzene molecules on a metal surface. Direct visualization is obtained for the intermolecular attraction and the "windmill" pattern of bonding among the fully halogenated molecules. Our results provide a hitherto missing understanding of the nature of the halogen bond. (Source: ScienceNOW)
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Han, Z., Czap, G., Chiang, C.-l., Xu, C., Wagner, P. J., Wei, X., Zhang, Y., Wu, R., Ho, W. Tags: Chemistry reports Source Type: news

Hanbury Brown and Twiss interferometry of single phonons from an optomechanical resonator
Nano- and micromechanical solid-state quantum devices have become a focus of attention. Reliably generating nonclassical states of their motion is of interest both for addressing fundamental questions about macroscopic quantum phenomena and for developing quantum technologies in the domains of sensing and transduction. We used quantum optical control techniques to conditionally generate single-phonon Fock states of a nanomechanical resonator. We performed a Hanbury Brown and Twiss–type experiment that verified the nonclassical nature of the phonon state without requiring full state reconstruction. Our result establis...
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Hong, S., Riedinger, R., Marinkovic, I., Wallucks, A., Hofer, S. G., Norte, R. A., Aspelmeyer, M., Gröblacher, S. Tags: Physics reports Source Type: news

Quantum acoustics with superconducting qubits
Mechanical objects have important practical applications in the fields of quantum information and metrology as quantum memories or transducers for measuring and connecting different types of quantum systems. The field of electromechanics is in pursuit of a robust and highly coherent device that couples motion to nonlinear quantum objects such as superconducting qubits. Here, we experimentally demonstrate a high-frequency bulk acoustic wave resonator that is strongly coupled to a superconducting qubit using piezoelectric transduction with a cooperativity of 260. We measure qubit and mechanical coherence times on the order o...
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Chu, Y., Kharel, P., Renninger, W. H., Burkhart, L. D., Frunzio, L., Rakich, P. T., Schoelkopf, R. J. Tags: Physics, Applied reports Source Type: news

The Drosophila embryo at single-cell transcriptome resolution
By the onset of morphogenesis, Drosophila embryos consist of about 6000 cells that express distinct gene combinations. Here, we used single-cell sequencing of precisely staged embryos and devised DistMap, a computational mapping strategy to reconstruct the embryo and to predict spatial gene expression approaching single-cell resolution. We produced a virtual embryo with about 8000 expressed genes per cell. Our interactive Drosophila Virtual Expression eXplorer (DVEX) database generates three-dimensional virtual in situ hybridizations and computes gene expression gradients. We used DVEX to uncover patterned expression of tr...
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Karaiskos, N., Wahle, P., Alles, J., Boltengagen, A., Ayoub, S., Kipar, C., Kocks, C., Rajewsky, N., Zinzen, R. P. Tags: Development r-articles Source Type: news

Measuring Earth's carbon cycle
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Source: ScienceNOW - October 12, 2017 Category: Science Authors: Smith, J. Tags: special/intro Source Type: news

Aqueous azobenzene switching
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Source: ScienceNOW - October 12, 2017 Category: Science Authors: Szuromi, P. Tags: twil Source Type: news

Subtleties of growing iron sulfides
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Source: ScienceNOW - October 12, 2017 Category: Science Authors: Lavine, M. S. Tags: twil Source Type: news

More undergraduates, more publications
(Source: ScienceNOW)
Source: ScienceNOW - October 12, 2017 Category: Science Authors: McCartney, M. Tags: twil Source Type: news

Not missing the origins of lncRNAs
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Source: ScienceNOW - October 12, 2017 Category: Science Authors: Zahn, L. M. Tags: twil Source Type: news

Blood test for early-stage cancer
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Source: ScienceNOW - October 12, 2017 Category: Science Authors: Kelly, P. N. Tags: twil Source Type: news

For diabetes screening, race matters
(Source: ScienceNOW)
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Kiberstis, P. A. Tags: twil Source Type: news

Coffee plants benefit from ant dung
(Source: ScienceNOW)
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Morris, E. Tags: twil Source Type: news

Type III interferons prime neutrophils
(Source: ScienceNOW)
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Balasubramani, A. Tags: twis Source Type: news

An expanded view of disordered proteins
(Source: ScienceNOW)
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Vinson, V. Tags: Biochemistry twis Source Type: news

Teaching an enzyme to switch sites
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Source: ScienceNOW - October 12, 2017 Category: Science Authors: Yeston, J. Tags: Biochemistry, Chemistry twis Source Type: news

A gram-scale route to bryostatin
(Source: ScienceNOW)
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Yeston, J. Tags: Chemistry, Medicine, Diseases twis Source Type: news

Visualizing halogen bonding
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Source: ScienceNOW - October 12, 2017 Category: Science Authors: Szuromi, P. Tags: Chemistry twis Source Type: news

A radical route from methane to methanol
(Source: ScienceNOW)
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Szuromi, P. Tags: Chemistry twis Source Type: news

Light- and dark-zone death dynamics
(Source: ScienceNOW)
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Scanlon, S. T. Tags: Immunology twis Source Type: news

Newborn brain imaging made easier
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Source: ScienceNOW - October 12, 2017 Category: Science Authors: Maroso, M. Tags: twis Source Type: news

Fevers, TRPV channels, and birth defects
(Source: ScienceNOW)
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Wong, W. Tags: twis Source Type: news

Forests out of balance
(Source: ScienceNOW)
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Smith, H. J. Tags: Geochemistry, Geophysics twis Source Type: news

A signature event for organoids
(Source: ScienceNOW)
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Kiberstis, P. A. Tags: Genetics, Medicine, Diseases twis Source Type: news

3D texture morphing for camouflage
(Source: ScienceNOW)
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Lavine, M. S. Tags: Physics, Applied twis Source Type: news

Mechanical systems at the quantum level
(Source: ScienceNOW)
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Osborne, I. S. Tags: Physics twis Source Type: news

3D gene expression blueprint of the fly
(Source: ScienceNOW)
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Purnell, B. A. Tags: Development twis Source Type: news

Measuring the far side of the Galaxy
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Source: ScienceNOW - October 12, 2017 Category: Science Authors: Smith, K. T. Tags: Astronomy twis Source Type: news

Sand in demand: Trapped behind dams
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Source: ScienceNOW - October 12, 2017 Category: Science Authors: Gomby, G. Tags: letters Source Type: news

Brazil's scientists and churches share goals
(Source: ScienceNOW)
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Fadini, R., Fernandes, G. W. Tags: letters Source Type: news