Sea Urchins as a Model of Negligible Senescence
Species that exhibit negligible senescence tend to be long-lived, but more interestingly appear to exhibit few to none of the functional declines of degenerative aging until very late in life, quite unlike the situation for most mammals, and particularly for humans. One can argue that the most useful species that exhibit negligible senescence are those with near relative species that age more normally. The closer the relative, the more likely it is that comparing the biochemistry of the two will lead to new knowledge regarding aging. So naked mole rats versus other, less long-lived mole rats, Brandt's bat versus other shor...
Source: Fight Aging! - April 17, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Addiction Insights: 8 Key Psychology Studies
Discover the powerful role played by cognitions, motivation, the emotions, and biology in trying to beat addiction. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - April 14, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Addiction Source Type: blogs
Fight Aging! Newsletter, April 15th 2024
In conclusion, although several clinical trials targeting SnCs are ongoing, various questions about the biology of SnCs remain open, resulting in a gap between molecular and cellular data. Concerning the need, initiatives such as SenNet aiming to create openly accessible atlases of SnCs should contribute enormously to the area. Advances in understanding the subcellular structure, the heterogeneity, and the dynamics of SnCs require the integration of molecular and cellular techniques with data analysis packages to evaluate high throughput evidence from microscopy and flow cytometry. It is also necessary to develop new equip...
Source: Fight Aging! - April 14, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Culling in the name of …
If you have even a passing interest in the natural world, you will have most likely heard the phrase “invasive species”. By definition, a deliberate or accidental release of a species to an area beyond its natural environment where it then multiplies and causes damage to that environment and the native wildlife that relies on it. I discussed the UK issue of invasive species briefly last year and in the context of Muntjac and Black Hairstreak butterfly too.
Ecologist and conservationist Hugh Warwick tackles the issue in much more depth in his latest book – Cull of the Wild. Warwick is, as most of us are, ...
Source: David Bradley Sciencebase - Songs, Snaps, Science - April 12, 2024 Category: Science Authors: David Bradley Tags: Biology Environment Science Source Type: blogs
Pulse of Progress: Looking Back, Moving Forward | TAPP 147
In Episode 147, host Kevin Patton reviews thehighlights and events of theprevious year in theworld of The A&P Professor. He then turns to last year ' s predictions for teaching human anatomy and physiology to see if he was on the right track. Finally,predictions for the coming year are revealed. And lots of other stuff —this episode istwo hours long, after all!0:00:00 | Introduction0:00:50 | Debrief: Topics, Stats, Reflections0:21:28 | A Long, Long, Long Episode0:23:05 | Debrief: More Reviewing& Reflecting0:38:59 | Did I Get My Predictions Right?0:50:22 | Textbook& Academic Authors Association0:57:47 | Lookin...
Source: The A and P Professor - April 12, 2024 Category: Physiology Authors: Kevin Patton Source Type: blogs
Political Science
I always do my best to write clearly and precisely, but it seems I don ' t always manage to get my meaning across. So let ' s try a couple of ideas again. Please read carefully, and think about what I actually write, not what you think I might think or what other people think. The First Amendment applies only to government. It constrains what government can do, it does not place any constraint of any kind on any other entity. The courts have interpreted it a bit more broadly than its literal language. If " congress shall make no law . . . " then the executive cannot have any legal authority to do what no law permits. ...
Source: Stayin' Alive - April 10, 2024 Category: American Health Source Type: blogs
A Look at the Research Yet to be Accomplished for Cellular Senescence
In conclusion, although several clinical trials targeting SnCs are ongoing, various questions about the biology of SnCs remain open, resulting in a gap between molecular and cellular data. Concerning the need, initiatives such as SenNet aiming to create openly accessible atlases of SnCs should contribute enormously to the area. Advances in understanding the subcellular structure, the heterogeneity, and the dynamics of SnCs require the integration of molecular and cellular techniques with data analysis packages to evaluate high throughput evidence from microscopy and flow cytometry. It is also necessary to develop new equip...
Source: Fight Aging! - April 10, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Technobabble To English: A Buzzword Guide For Medical AI And Digital Health
Navigating AI in medicine and digital health can feel like ordering a coffee at that new hipster café downtown: exciting yet slightly overwhelming with a menu that seems to be in a different language. A while ago we published a buzzword dictionary to help you decode the most frequently repeated terms. Back then artificial intelligence and machine learning were rarely heard exotic expressions, but as quite a few years have passed, a whole new set of mambo-jambo emerged, waiting to be explained.
You’re probably sick of hearing the latest digital health buzzwords without any actual context, so let’s translat...
Source: The Medical Futurist - April 4, 2024 Category: Information Technology Authors: Andrea Koncz Tags: TMF Artificial Intelligence in Medicine buzzword AI in medicine generative AI in medicine Source Type: blogs
Interview with Stefany Shaheen: Revolutionizing diabetes care through cell therapies
I had the extraordinary opportunity to chat with Stefany Shaheen, the Chief Strategy Officer of Advanced Regenerative Manufacturing Institute (ARMI) and BioFab USA, about the transformative potential of cell therapies for individuals living with diabetes. Stefany shared her remarkable journey, insights on cell therapies’ current status, approval challenges, and how the diabetes community can contribute to advancing research in this field.
A few months before this discussion with Stefany, I had the opportunity to hear Dean Kamen speak at the recent ...
Source: Scott's Diabetes Blog - April 1, 2024 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs
Fight Aging! Newsletter, April 1st 2024
This study supports the proposed model that aging-related loss of colonic crypt epithelial cell AMP gene expression can promote increased relative abundances of Gn inflammaging-associated bacteria and gene expression markers of colonic inflammaging. These data may support new targets for aging-related therapies based on intestinal genes and microbiomes.
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A Skeptical View of the Role of Nuclear DNA Damage in Aging
https://www.fightaging.org/archives/2024/03/a-skeptical-view-of-the-role-of-nuclear-dna-damage-in-aging/
It is evident and settled that stochastic nuclear DNA damag...
Source: Fight Aging! - March 31, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Long and Tortured History of Alpha-Synuclein and Parkinson ’s Disease
This study tracks the decades-long journey to harness alpha-synuclein as a treatment for Parkinson’s disease. Steven Zecola an activist who tracks Parkinson’s research and was on THCB last month discussing it, offers three key changes needed to overcome the underlying challenges.
A Quick Start for Alpha-Synuclein R&D
In the mid-1990’s, Parkinson’s patient advocacy groups had become impatient by the absence of any major therapeutic advances in the 25 years since L-dopa had been approved for Parkinson’s disease (PD).
The Director of National Institute of Neurological Disorders and Stroke (NINDS) se...
Source: The Health Care Blog - March 29, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Medical Practice Parkinson's Disease Steven Zecola Source Type: blogs
Investigating the Primary Cilium: Q & A With Xuecai Ge
Credit: Courtesy of Dr. Xuecai Ge.
The brain is a large and complex organ, but some very small structures guide its development. Xuecai Ge, Ph.D., an associate professor of molecular and cell biology at the University of California, Merced (UC Merced), has devoted her career to understanding one of these structures called the primary cilium. In an interview, Dr. Ge shared how her childhood experience inspired her to study science and what makes the primary cilium fascinating.
Q: How did you first become interested in science?
A: When I was a little kid, my mom was a primary care doctor, and I saw her treat patients...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - March 27, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cells Cellular Processes Profiles Source Type: blogs
More Commentary on the Role of PF4 in Reducing Brain Inflammation
Platelets in the blood are not just involved in clotting. Near every aspect of our biology has evolved many different functions, and the complexity of our biochemistry is still far from fully explored. Increased platelet factor 4 (PF4) shows up as a feature in a number of different interventions known to reduce inflammation in the aging brain. Researchers are now moving in the direction of developing therapies for neurodegenerative conditions based on the upregulation of PF4 or the delivery of recombinant PF4.
Platelets are a component of blood best known for their role in clotting, but research in recent years ha...
Source: Fight Aging! - March 27, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, March 25th 2024
This study also reports the expansion of satellite cells in human muscle with CR. This finding is critical to suggest translational relevance to the rodent data observed for more than a decade. Moreover, the increased expression of the plasminogen receptor Plg-RKT observed on human satellite cells during CR provided additional support for the theory that our rodent model is relevant to human biology.
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Interesting Insight into the Relationship Between TP53, Telomerase, and Telomere Length
https://www.fightaging.org/archives/2024/03/interesting-insight-into-the-relationship-between-t...
Source: Fight Aging! - March 24, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Microplastics, Major Problem
By KIM BELLARD
It’s been almost four years since I first wrote about microplastics; long story short, they’re everywhere. In the ground, in the oceans (even at the very bottom), in the atmosphere. More to the point, they’re in the air you breathe and in the food you eat. They’re in you, and no one thinks that is a good thing. But we’re only starting to understand the harm they cause.
The Washington Post recently reported:
Scientists have found microplastics — or their tinier cousins, nanoplastics — embedded in the human placenta, in blood, in the heart and in the liver and bowels. In one re...
Source: The Health Care Blog - March 19, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Tech Kim Bellard Microplastics Source Type: blogs
