FDA approves Orchard ’s gene therapy for children with rare genetic disease
This decision marks the first FDA-approved treatment for children with a rare genetic disease called metachromatic leukodystrophy (MLD) and Orchard's entry into the U.S. drug market. (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - March 18, 2024 Category: Pharmaceuticals Authors: Hannah Green Source Type: news

This Mutation Likely Saved a Colon Cancer Patient's Life
His tumor had a specific genetic makeup known as mismatch repair-deficient, present in 5% to 10% of all rectal cancer patients, meaning he might qualify for a cutting-edge immunotherapy. (Source: WebMD Health)
Source: WebMD Health - March 18, 2024 Category: Consumer Health News Source Type: news

Genetic Factors Influence Subsequent Cancer Risk in Childhood Cancer Survivors
MONDAY, March 18, 2024 -- Polygenic risk scores (PRSs) derived from the general population are associated with a subsequent risk for certain cancers among survivors of childhood cancer, with an additive risk for PRS and radiotherapy, according to a... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 18, 2024 Category: Pharmaceuticals Source Type: news

The Most Exciting New Advances in Managing COPD
The Global Initiative for Chronic Obstructive Lung Disease, or GOLD, is the world’s preeminent COPD research and advocacy organization. Founded in 1997 in collaboration with the U.S. National Institutes of Health and the World Health Organization, one of GOLD’s stated aims is to “improve prevention and treatment of this lung disease.” In its 2023 global strategy report, GOLD changed its definition of COPD—which many in the profession viewed as overdue. Specifically, the new definition emphasized the heterogeneity of COPD in terms of its underlying drivers and long-term disease course. [ti...
Source: TIME: Health - March 18, 2024 Category: Consumer Health News Authors: Markham Heid Tags: Uncategorized freelance Source Type: news

Epistasis in neurotransmitter receptors linked to posttraumatic stress disorder and major depressive disorder comorbidity in traumatized Chinese - Xu L, Zhang J, Yang H, Cao C, Fang R, Liu P, Luo S, Wang B, Zhang K, Wang L.
BACKGROUND: Posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) comorbidity occurs through exposure to trauma with genetic susceptibility. Neuropeptide-Y (NPY) and dopamine are neurotransmitters associated with anxiety and stress-relat... (Source: SafetyLit)
Source: SafetyLit - March 18, 2024 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder - Bigdeli TB, Barr PB, Rajeevan N, Graham DP, Li Y, Meyers JL, Gorman BR, Peterson RE, Sayward F, Radhakrishnan K, Natarajan S, Nielsen DA, Wilkinson AV, Malhotra AK, Zhao H, Brophy M, Shi Y, O'Leary TJ, Gleason T, Przygodzki R, Pyarajan S, Muralidhar S, Gaziano JM, Huang GD, Concato J, Siever LJ, Delisi LE, Kimbrel NA, Beckham JC, Swann AC, Kosten TR, Fanous AH, Aslan M, Harvey PD.
Persons diagnosed with schizophrenia (SCZ) or bipolar I disorder (BPI) are at high risk for self-injurious behavior, suicidal ideation, and suicidal behaviors (SB). Characterizing associations between diagnosed health problems, prior pharmacological treatm... (Source: SafetyLit)
Source: SafetyLit - March 18, 2024 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Hyperuricemia Subtypes in Gout Show Distinct Traits Hyperuricemia Subtypes in Gout Show Distinct Traits
The distinct biologic features of different hyperuricemia subtypes call for the development of tailored, subtype-dependent, genetics-based therapies for gout or hyperuricemia.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 18, 2024 Category: Consumer Health News Tags: Rheumatology Source Type: news

Adverse Childhood Experiences Tied to Adult Mental Health Outcomes
FRIDAY, March 15, 2024 -- Associations between adverse childhood experiences (ACEs) and adult mental health outcomes remain significant even after controlling for shared genetic and environmental factors, according to a study published online March... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 15, 2024 Category: Pharmaceuticals Source Type: news

Interaction between PTSD-PRS and trauma affects PTSD likelihood in women victims of sexual assault - Bugiga AVG, Carvalho CM, Oliveira AM, Coimbra BM, Chehimi SN, Zanardo EA, Kulikowski LD, Mello AF, Ota VK, Mello MF, Belangero SI.
OBJECTIVE: Post-traumatic stress disorder (PTSD) is triggered by traumatic events, but genetic vulnerability and a history of childhood trauma are additional factors that may increase the risk of PTSD. Thus, our study focused on exploring the interaction b... (Source: SafetyLit)
Source: SafetyLit - March 15, 2024 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Learn how Developments in Genetic Medicine are Improving Treatment of Cancer
Discover the latest innovations in therapeutic technology on an upcoming segment of Advancements. JUPITER, Fla., March 15, 2024 /PRNewswire-PRWeb/ -- Advancements with Ted Danson is excited to announce a new segment featuring groundbreaking approaches in genetic medicine that are... (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - March 15, 2024 Category: Pharmaceuticals Source Type: news

A treaty to prepare the world for the next pandemic hangs in the balance
“Me first”—that’s how Tedros Adhanom Ghebreyesus, head of the World Health Organization (WHO), described the wealthy world’s response to the COVID-19 pandemic when he kicked off negotiations for a global “pandemic treaty” in December 2021. Even before vaccines had proved safe and effective, rich countries had purchased enough doses to cover their entire population several times, whereas lower and middle-income countries had little or no vaccine. The pandemic treaty would address that searing inequity, Tedros vowed, along with many other problems identified during the COVID-19 pandemic, leaving the world bette...
Source: ScienceNOW - March 15, 2024 Category: Science Source Type: news

Volpara to highlight Miss. health system project at NCBC
Volpara Health Technologies will feature its latest software for breast density, evaluating cancer risk, and mammography quality with Lunit's Insight AI software for early cancer detection at the 2024 National Consortium of Breast Centers (NCBC) conference in Las Vegas. During a special session on Tuesday, March 19, Tami Hudson, breast health navigator at Singing River Health System in Mississippi will share the clinical impact of making cancer risk assessment standard for every patient receiving a mammogram at four breast centers. Singing River has used Volpara's Risk Pathways cancer risk assessment software to identify ...
Source: AuntMinnie.com Headlines - March 15, 2024 Category: Radiology Authors: AuntMinnie.com staff writers Tags: Imaging Informatics Breast Imaging Subspecialties Industry News Source Type: news

Enhancing camera calibration for traffic surveillance with an integrated approach of genetic algorithm and particle swarm optimization - Li S, Yoon HS.
Recent advancements in sensor technologies, coupled with signal processing and machine learning, have enabled real-time traffic control systems to effectively adapt to changing traffic conditions. Cameras, as sensors, offer a cost-effective means to determ... (Source: SafetyLit)
Source: SafetyLit - March 15, 2024 Category: International Medicine & Public Health Tags: Engineering, Physics, Structural Soundness and Failure Source Type: news

Patterns and predictors of alcohol misuse trajectories from adolescence through early midlife - Stephenson M, Barr P, Thomas N, Cooke M, Latvala A, Rose RJ, Kaprio J, Dick D, Salvatore JE.
We took a multilevel developmental contextual approach and characterized trajectories of alcohol misuse from adolescence through early midlife, examined genetic and environmental contributions to individual differences in those trajectories, and identified... (Source: SafetyLit)
Source: SafetyLit - March 15, 2024 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Engineering the Microbiome: CRISPR Leads the Way
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes. (Source: The Scientist)
Source: The Scientist - March 15, 2024 Category: Science Tags: Features Magazine Issue Source Type: news