Mother's smoking habits affects IL10 methylation but not asthma in Ecuadorian children
ConclusionSmoking habit could be essential as an environmental exposure factor in regulating gene expression in children with asthma. (Source: Molecular Genetics & Genomic Medicine)
Source: Molecular Genetics & Genomic Medicine - April 27, 2024 Category: Genetics & Stem Cells Authors: Cristina Ochoa ‐Avilés,
Angélica Ochoa‐Avilés,
Roque Rivas‐Párraga,
Samuel Escandón,
Talita Dos Santos‐Jesus,
Milca de J. Silva,
Valderiene Leão,
Marco Salinas,
Yosselin Vicuña,
Lucy Baldeón,
María José Molina‐Cando,
Diana M Tags: ORIGINAL ARTICLE Source Type: research
Pharmacogenetic variability of tuberculosis biomarkers in native and mestizo Peruvian populations
Linkage disequilibrium for SNPs associated with metabolizerNAT2. (A) mestizo population (B) native population. AbstractIn Peru, 29 292 people were diagnosed with tuberculosis in 2022. Although tuberculosis treatments are effective, 3.4%–13% are associated with significant adverse drug reactions, with drug-induced liver injury (DILI) considered the most predominant. Among the first-line antituberculosis drugs, isoniazid is the main drug responsible for the appearance of DILI. In liver, isoniazid (INH) is metabolized by N-acetyltransferase-2 (NAT2) and cytochrome P450 2E1 (CYP2E1). Limited information exists on genetic ...
Source: Pharmacology Research and Perspectives - April 27, 2024 Category: Drugs & Pharmacology Authors: Luis Jaramillo ‐Valverde,
Kelly S. Levano,
David D. Tarazona,
Silvia Capristano,
Cesar Sanchez,
Julio A. Poterico,
Eduardo Tarazona‐Santos,
Heinner Guio Tags: ORIGINAL ARTICLE Source Type: research
Genes, Vol. 15, Pages 556: The Relationship between miR-5682 and Nutritional Status of Radiotherapy-Treated Male Laryngeal Cancer Patients
Conclusions: analysis of miR-5682 expression demonstrates a potential clinical utility in selection of LC patients suffering from nutritional deficiencies developing as a consequence of RT-based therapy. (Source: Genes)
Source: Genes - April 27, 2024 Category: Genetics & Stem Cells Authors: Marcin Mazurek Anna Brzozowska Miros ław Maziarz Teresa Ma łecka-Massalska Tomasz Powr ózek Tags: Article Source Type: research
Genes, Vol. 15, Pages 559: Optical Genome Mapping as a New Tool to Overcome Conventional Cytogenetics Limitations in Patients with Bone Marrow Failure
ez
Julián Sevilla
Cytogenetic studies are essential in the diagnosis and follow up of patients with bone marrow failure syndromes (BMFSs), but obtaining good quality results is often challenging due to hypocellularity. Optical Genome Mapping (OGM), a novel technology capable of detecting most types chromosomal structural variants (SVs) at high resolution, is being increasingly used in many settings, including hematologic malignancies. Herein, we compared conventional cytogenetic techniques to OGM in 20 patients with diverse BMFSs. Twenty metaphases for the karyotype were only obtained in three subjects (15%), and no...
Source: Genes - April 27, 2024 Category: Genetics & Stem Cells Authors: June Iriondo Ana G ómez Josune Zubicaray Jorge Garcia-Martinez Lorea Abad Carmen Matesanz Reyes Gim énez Almudena Gal án Alejandro Sanz Elena Sebasti án Jes ús Gonzalez de Pablo Ana de la Cruz Manuel Ram írez Juli án Sevilla Tags: Article Source Type: research
Genes, Vol. 15, Pages 560: Exploring the Role of E6 and E7 Oncoproteins in Cervical Oncogenesis through MBD2/3-NuRD Complex Chromatin Remodeling
Conclusions: The impacted genes primarily play roles in governing gene transcription, mRNA processing, and regulation of translation. Understanding these mechanisms offers valuable insights into the process of HPV-induced oncogenesis. (Source: Genes)
Source: Genes - April 27, 2024 Category: Genetics & Stem Cells Authors: Alina Fudulu Carmen Cristina Diaconu Iulia Virginia Iancu Adriana Plesa Adrian Albulescu Marinela Bostan Demetra Gabriela Socolov Irina Liviana Stoian Raluca Balan Gabriela Anton Anca Botezatu Tags: Article Source Type: research
AAV-vectored expression of monospecific or bispecific monoclonal antibodies protects mice from lethal Pseudomonas aeruginosa pneumonia
Gene Therapy, Published online: 27 April 2024; doi:10.1038/s41434-024-00453-1AAV-vectored expression of monospecific or bispecific monoclonal antibodies protects mice from lethal Pseudomonas aeruginosa pneumonia (Source: Gene Therapy)
Source: Gene Therapy - April 27, 2024 Category: Genetics & Stem Cells Authors: Jordyn A. Lopes Nicole E. Garnier Yanlong Pei Jacob G. E. Yates Elena S. B. Campbell Melanie M. Goens Madison E. Hughes Amira D. Rghei Brenna A. Y. Stevens Matthew M. Guilleman Brad Thompson Cezar M. Khursigara Leonardo Susta Sarah K. Wootton Source Type: research
Negotiating severity behind the scenes: prenatal testing in Germany
European Journal of Human Genetics, Published online: 27 April 2024; doi:10.1038/s41431-024-01612-zNegotiating severity behind the scenes: prenatal testing in Germany (Source: European Journal of Human Genetics)
Source: European Journal of Human Genetics - April 27, 2024 Category: Genetics & Stem Cells Authors: Tamar Nov-Klaiman Hilary Bowman-Smart Ruth Horn Source Type: research
Genes, Vol. 15, Pages 558: Genetic Mechanisms Driving Uterine Leiomyoma Pathobiology, Epidemiology, and Treatment
Borahay
Uterine leiomyomas (ULs) are the most common benign tumor of the uterus. They can be associated with symptoms including abnormal uterine bleeding, pelvic pain, urinary frequency, and pregnancy complications. Despite the high prevalence of UL, its underlying pathophysiology mechanisms have historically been poorly understood. Several mechanisms of pathogenesis have been suggested, implicating various genes, growth factors, cytokines, chemokines, and microRNA aberrations. The purpose of this study is to summarize the current research on the relationship of genetics with UL. Specifically, we performed a literature...
Source: Genes - April 27, 2024 Category: Genetics & Stem Cells Authors: Malini S. Ramaiyer Eslam Saad Irem Kurt Mostafa A. Borahay Tags: Review Source Type: research
Genes, Vol. 15, Pages 557: Complete Mitochondrial Genome of Four Peristediidae Fish Species: Genome Characterization and Phylogenetic Analysis
ang Gao
The systematic revision of the family Peristediidae remains an unresolved issue due to their diverse and unique morphology. Despite the popularity of using mitochondrial genome research to comprehensively understand phylogenetic relationships in fish, genetic data for peristediid fish need to be included. Therefore, this study aims to investigate the mitochondrial genomic characteristics and intra-family phylogenetic relationships of Peristediidae by utilizing mitochondrial genome analysis. Therefore, this study aims to investigate the phylogenetic relationship of Peristediidae by utilizing mitochondrial genome...
Source: Genes - April 27, 2024 Category: Genetics & Stem Cells Authors: Xianhui Liao Yijia Shih Chenghao Jia Tianxiang Gao Tags: Article Source Type: research
Molecules, Vol. 29, Pages 2014: Polyphenols of the Inuleae-Inulinae and Their Biological Activities: A Review
owska
Polyphenols are ubiquitous plant metabolites that demonstrate biological activities essential to plant–environment interactions. They are of interest to plant food consumers, as well as to the food, pharmaceutical and cosmetic industry. The class of the plant metabolites comprises both widespread (chlorogenic acids, luteolin, quercetin) and unique compounds of diverse chemical structures but of the common biosynthetic origin. Polyphenols next to sesquiterpenoids are regarded as the major class of the Inuleae-Inulinae metabolites responsible for the pharmacological activity of medicinal plants from t...
Source: Molecules - April 27, 2024 Category: Chemistry Authors: Janusz Malarz Klaudia Michalska Anna Stojakowska Tags: Review Source Type: research
All dog noses —whether a pug’s or a bloodhound’s—are created equal
This study also did not test dogs in the field, where some breeds might outshine others in hunting parties, search-and-rescue operations, or narcotics searches because of endurance, trainability, or a desire to please humans.
In the end, our perception that some dogs are better sniffers than others may be a self-perpetuating prophecy: “In this case, it’s not necessarily that their noses are exceptionally good,” Karlsson says, “but that they’re interested in using their noses to help us complete something that we want them to do.” (Source: Science of Aging Knowledge Environment)
Source: Science of Aging Knowledge Environment - April 26, 2024 Category: Geriatrics Source Type: research
Rare mutation that causes short stature may shed light on ageing
The genetic variant, which causes people to be insensitive to growth hormone, may also protect people from heart disease (Source: New Scientist - Health)
Source: New Scientist - Health - April 26, 2024 Category: Consumer Health News Source Type: research
GSE265893 RNA-seq of E0771-Vector control and E0771-Malt1-WT at basal condition
Contributors : Yuwei Tao ; Chen Tian ; Hanqiu ZhengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo reveal the downstream signal change induced by Malt1, we collected mRNA samples from Vector control- and WT-Malt1-expressing E0771 cancer cells, and performed RNA-seq analysis. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 26, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Biochemical and Molecular Basis of Chemically Induced Defense Activation in Maize against Banded Leaf and Sheath Blight Disease
This study aimed to understand the resistance mechanisms against banded leaf and sheath blight (BLSB) in maize hybrid "Vivek QPM-9". Seven fungicides at recommended doses (1000 and 500 ppm) and two plant defense inducers, salicylic acid (SA) and jasmonic acid (JA) at concentrations of 50 and 100 ppm, were applied. Fungicides, notably Azoxystrobin and Trifloxystrobin + Tebuconazole, demonstrated superior efficacy against BLSB, while Pencycuron showed limited effectiveness. Field-sprayed Azoxystrobin exhibited the lowest BLSB infection, correlating with heightened antioxidant enzyme activity (SOD, CAT, POX, β-1,3-glucanase,...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Shah Mahmood Hamidi Shweta Meshram Aundy Kumar Archana Singh Rajbir Yadav Robin Gogoi Source Type: research
NBR1-dependent Autophagy Activation Protects Against Environmental Cadmium-evoked Placental Trophoblast Senescence
In this study, we employed animal experiments, cell culture, and case-control study to investigate the above mentioned. We have demonstrated that exposure to Cd during gestation induces placental senescence and activates autophagy. Pharmacological and genetic interventions further exacerbated placental senescence induced by Cd through the suppression of autophagy. Conversely, activation of autophagy ameliorated Cd-induced placental senescence. Knockdown of NBR1 exacerbated senescence in human placental trophoblast cells. Further investigations revealed that NBR1 facilitated the degradation of p21 via LC3B. Our case-control...
Source: Chemosphere - April 26, 2024 Category: Chemistry Authors: Qing Ling Yu-Feng Zhang Wei Chang Si-Ting Liu Hua-Long Zhu Hua Wang Source Type: research
